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Take Synthroid with water only on an empty stomach. Take Synthroid 4 hours before or after. taking iron or calcium supplements, or antacids. Soy, cottonseed meal, walnuts, fiber, and. grapefuit juice can affect the absorption of Synthroid.
Another method to remember. to take your SynthroidÂ® is to place one weekâs worth of pills in a single pill. box and make sure that one dayâs dose is gone at the end of each day. SynthroidÂ® should always be taken on an empty stomach. An empty. stomach means that it has been at least 2 - 3 hours since eating or drinking.