Patients with renal failure, usually end-stage renal disease (ESRD), commonly are afflicted by severe pruritus. The pathogenesis of ESRD pruritus is unknown, but improving the quality of dialysis can reduce the prevalence and severity of ESRD pruritus.
The earlier generation of Buick Park Avenue ran from 1991 through 1996, with substantial updates for the 1994 model year. It shared its underpinnings with the Oldsmobile 98, that make's largest sedan, as well as a number of Cadillac front-wheel-drive sedans.
Opel designed and manufactured vehicles are also sold under the Buick brand in the United States, Canada, Mexico, and China, the Holden brand in Australia and New Zealand and the Vauxhall brand in the United Kingdom. Opel traces its roots to a sewing machine manufacturer founded by Adam Opel in 1862. The company began manufacturing bicycles in 1886 and produced its first automobile in 1899.