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Polar molecules are hydrophylic. Because the inner portion of the phospholipid bilayer (plasma membrane) consists of hydrophobic interactions, generally polar molecules cannotâ¦ pass directly though. These molecules require protein channels to actively or passively move between the cytosol and the plasma membrane.
They can not be stored because they can diffuse across both the vesicle membrane and the plasma membrane by passive diffusion. Thus, as soon as they are synthesized they are released into the blood. Both the vesicle membrane and plasma membrane are made of a phospholipid bi-layer with a hydrophobic center. This hydrophobic center prevents polor and hydrophilic molecules (like peptide hormones) from crossing. Thus peptide hormones can be stored, but small hydrophobic molecules like steroids and other lipid hormones cannot be stored.