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Insulin resistance can commonly develop if one or more of the following factors apply: 1  If you are overweight or obese. 2  Having a high-calorie diet, high-carbohydrate or high-sugar diet. 3  Sedentary lifestyle â taking little physical activity.  Taking high doses of steroids over an extended period of 1  time. Having chronic stress.
1 Insulin resistance is a condition in which the cells of the body become resistant to the hormone insulin. 2  Insulin resistance may be part of the metabolic syndrome, and it has been associated with higher risk of developing heart disease. 3  Insulin resistance precedes the development of type 2 diabetes (T2D).nsulin is a hormone that is produced by the beta cells of the pancreas. These cells are scattered throughout the pancreas in small clusters known as the islets of Langerhans. The insulin produced is released into the blood stream and travels throughout the body.