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Acinic cell carcinoma (ACC) is a low-grade malignant salivary neoplasm that constitutes approximately 17% of primary salivary gland malignancies. In the head and neck region, the parotid gland is the predominant site of origin and women are usually more frequently diagnosed than men.
Acinic cell carcinoma cells growing in a solid pattern. Most of the tumor cells demonstrate fine serous cytoplasmic granules, resembling the normal serous acinar salivary gland cells. Some tumor cells with a clear cytoplasm are also noted (H&E stain, original magnification 400 Ã).