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What is PUVA? PUVA or photochemotherapy is a type of ultraviolet radiation treatment (phototherapy) used for severe skin diseases. PUVA is a combination treatment which consists of Psoralens (P) and then exposing the skin to UVA (long wave ultraviolet radiation). It has been available in its present form since 1976.
Psoralens and ultraviolet A light (PUVA) therapy is contraindicated in any of the following conditions: 1  History of arsenic exposure; or. 2  History of ionizing radiation exposure; or. 3  History or presence of melanoma or other skin cancer; or.  Pregnancy.