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Mayonnaise is a popular treatment for getting rid of head lice. It is affordable and safe. However, mayonnaise does not remove nits, the eggs laid by head lice. If you use mayonnaise to kill head lice, you will have to use another method, such as combing with a fine-toothed comb, to remove nits.
There are quite a few over-the-counter products that claim to kill lice or their eggs (nits). The over-the-counter hair products that have been around the longest and are recommended to treat head lice and pubic lice are: Permethrin 1% creme rinse (such as Nix). Pyrethrins and piperonyl butoxide shampoo (such as RID).