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Physical symptoms of neurological problems may include the following: 1  Partial or complete paralysis. 2  Muscle weakness. 3  Partial or complete loss of sensation. 4  Seizures. Difficulty reading and writing.  Poor cognitive 1  abilities. Unexplained 2  pain. Decreased alertness.
Signs and Symptoms ALS affects the upper motor neurons, which are in the brain, and the lower motor neurons, which are in the spinal cord and brainstem. Upper motor neuron degeneration generally causesspasticity (tightness in a muscle), while lower motor neuron degeneration causes muscle weakness, muscle atrophy(shrinkage of muscles) and twitching.