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Insulin resistance can commonly develop if one or more of the following factors apply: 1  If you are overweight or obese. 2  Having a high-calorie diet, high-carbohydrate or high-sugar diet. 3  Sedentary lifestyle â taking little physical activity.  Taking high doses of steroids over an extended period of 1  time. Having chronic stress.
Difference Between Insulin Resistance and Diabetes. Insulin resistance occurs when insulin is produced by the body but not used effectively by the cells. Insulin is a hormone that allows cells throughout the body, particularly in the liver and in the muscles, to absorb glucose and use it to create energy. Insulin resistance interferes with that absorption and can lead to the development of pre-diabetes or type 2 diabetes. Insulin resistance has a strong genetic factor.