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Take Synthroid with water only on an empty stomach. Take Synthroid 4 hours before or after. taking iron or calcium supplements, or antacids. Soy, cottonseed meal, walnuts, fiber, and. grapefuit juice can affect the absorption of Synthroid.
synthroid, muscle, cramp, energy. I have been taking it for 2 weeks 125 mcg/day. I have felt no change in symptoms weakness in legs in the morning, no energy, unable to stand or walk for more than 15 mins. and muscle cramps. I tested positive for hypothroidism.