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Here are all the possible meanings and translations of the word hamstring. Princeton's WordNet(0.00 / 0 votes)Rate this definition: hamstring, hamstring tendon(verb) one of the tendons at the back of the knee. hamstring(verb) make ineffective or powerless. The teachers were hamstrung by the overly rigid schedules. hamstring(verb) cripple by cutting the hamstring.
, medial hamstringlateral hamstring (ham'string), 1  1. One of the tendons bounding the popliteal space on either side; the medial hamstring comprises the tendons of the semimembranosus and semitendinosus muscles; the lateral hamstring is the tendon of the biceps femoris muscle.