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Polar molecules are hydrophylic. Because the inner portion of the phospholipid bilayer (plasma membrane) consists of hydrophobic interactions, generally polar molecules cannotâ¦ pass directly though. These molecules require protein channels to actively or passively move between the cytosol and the plasma membrane.
The plasma membrane is selectively-permeable, which means that some substances can move across it freely while others cannot. Generally, nonpolar molecules and very small substances can diffuse across the membrane while large or polar molecules cannot. There are many different types of membrane proteins embedded in the plasma membrane.