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The proximal tubules make up a significant portion of the kidneys; proximal tubule epithelial cells are the most populous cell type in the kidney, and carry out diverse regulatory and endocrine functions where numerous transporters are located.he proximal tubules make up a significant portion of the kidneys; proximal tubule epithelial cells are the most populous cell type in the kidney, and carry out diverse regulatory and endocrine functions where numerous transporters are located.
Each nephron in the mammalian kidney is a long tubule, or extremely fine tube, about 30â55 mm (1.2â2.2 inches) long. At one end this tube is closed, expanded, and folded into a double-walled cuplike structure.