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How It Works. Leflunomide (Arava) is a disease-modifying antirheumatic drug (DMARD) that is used to treat rheumatoid arthritis. It interferes with the progression of the disease by blocking the production of white blood cells that cause the joint inflammation in rheumatoid arthritis.
A loading dose is sometimes given for medicines that take a long time to build up in the body. The loading dose of leflunomide is usually 100 mg (or five 20 mg tablets) once weekly for 3 weeks in addition to the regular daily dose. Other times doctors may prescribe a loading dose of 100 mg a day for the first 3 days after starting leflunomide.