You've probably noticed that a lot has changed from last season. Gone is the Team Captain and total starts per driver restriction from the roster building process. In its place is a new salary based system. This new roster selection process lets you pick any driver each race of the season.
BCR-ABL testing is ordered when a doctor suspects that a person has CML or Ph positive ALL. Initial testing may be indicated when a person has nonspecific symptoms such as fatigue, weight loss, joint or bone pain, and/or an enlarged spleen or as a follow-up to abnormal findings on a CBC.
Moreover, the BCR-ABL protein inhibits DNA repair, causing genomic instability and making the cell more susceptible to developing further genetic abnormalities. The action of the BCR-ABL protein is the pathophysiologic cause of chronic myelogenous leukemia. With improved understanding of the nature of the BCR-ABL protein and its action as a tyrosine kinase, targeted therapies (the first of which was imatinib) that specifically inhibit the activity of the BCR-ABL protein have been developed.