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Insulin resistance can commonly develop if one or more of the following factors apply: 1  If you are overweight or obese. 2  Having a high-calorie diet, high-carbohydrate or high-sugar diet. 3  Sedentary lifestyle â taking little physical activity.  Taking high doses of steroids over an extended period of 1  time. Having chronic stress.
Scientists have found different bits of DNA that affect how your body makes insulin. Extra weight. Being overweight or obese can cause insulin resistance, especially if you carry your extra pounds around the middle. Now type 2 diabetes affects kids and teens as well as adults, mainly because of childhood obesity.