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Polar molecules are hydrophylic. Because the inner portion of the phospholipid bilayer (plasma membrane) consists of hydrophobic interactions, generally polar molecules cannotâ¦ pass directly though. These molecules require protein channels to actively or passively move between the cytosol and the plasma membrane.
Polar molecules and large ions dissolved in water cannot diffuse freely across the plasma membrane due to the hydrophobic nature of the fatty acid tails of the phospholipids that make up the lipid bilayer.Only small, non-polar molecules, such as oxygen and carbon dioxide, can diffuse easily across the membrane.olar molecules and large ions dissolved in water cannot diffuse freely across the plasma membrane due to the hydrophobic nature of the fatty acid tails of the phospholipids that make up the lipid bilayer. Only small, non-polar molecules, such as oxygen and carbon dioxide, can diffuse easily across the membrane.