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How It Works. Leflunomide (Arava) is a disease-modifying antirheumatic drug (DMARD) that is used to treat rheumatoid arthritis. It interferes with the progression of the disease by blocking the production of white blood cells that cause the joint inflammation in rheumatoid arthritis.
Take leflunomide exactly as your doctor tells you to. It is taken once a day. Your doctor will prescribe a high-strength (100 mg) tablet for the first three days. After this, the strength of your tablets will be reduced to 10 mg or 20 mg, and you will stay on this lower dose. Swallow the tablet with a drink of water.