Nicotinic receptor activation causes the opening of the channel formed by the receptor. This increases the Na+ movement into the target cell, leading to depolarization and generation of the action potential. This rapidly developing change, termed a fast EPSP, is illustrated in Figures 4.3, and 6.2.
And, anecdotally at least, they act as an overall stimulant, producing a titillating, awakening effect and increasing the acuity of the senses. Peppers, especially the hot capsicum (chili) peppers, produce a burning sensation on the skin and mucous membranes, including the inside of the mouth. For the uninitiated, a relatively mild hot pepper can seem intolerably strong and truly hot peppers may even cause blistering of the lips and palate.
Pepper spray, unlike teargas, is not an irritant, it is an inflammatory agent. When a person is sprayed with pepper spray their eyes clamp shut, if they manage to open them they most likely will not see anything because the capillaries in their eyes will be dilated, causing temporary blindness.he active ingredient in pepper spray is also an inflammatory agent that swells up the eyes and mucous membranes of the upper respiratory tract, it causes pain, and often temporary blindness.