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Take Synthroid with water only on an empty stomach. Take Synthroid 4 hours before or after. taking iron or calcium supplements, or antacids. Soy, cottonseed meal, walnuts, fiber, and. grapefuit juice can affect the absorption of Synthroid.
Missing one day will not make a difference because the body has stored up Synthroid (etc.). One Synthroid (T4) pill stays in the system up 6 to 7 days. So if you miss a day, the system has reserves from the past 6 days of taken medication to fall back on. This is called shelf life.