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Take Synthroid with water only on an empty stomach. Take Synthroid 4 hours before or after. taking iron or calcium supplements, or antacids. Soy, cottonseed meal, walnuts, fiber, and. grapefuit juice can affect the absorption of Synthroid.
Soy products can also interfere with the absorption of SynthroidÂ®. Therefore, you should always allow four hours in between the time you take. your SynthroidÂ® and the time you take calcium supplements, multivitamins. with iron, or iron tablets.