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Take Synthroid with water only on an empty stomach. Take Synthroid 4 hours before or after. taking iron or calcium supplements, or antacids. Soy, cottonseed meal, walnuts, fiber, and. grapefuit juice can affect the absorption of Synthroid.
As synthroid treatment is continued for an extended duration, the body will have adjusted to the increase in basal metabolic rate (BMR), and additional weight loss will subside. For some users, weight loss may subside after a few months of treatment, yet for others it may take a year for the weight loss to diminish.