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However, sadness, depression, grief, or anxiety are a common cause of weight loss that is not explained by other factors, especially among the elderly. Cancer may also cause decreased appetite. You may lose weight without trying. Cancers that may cause you to lose your appetite include: 1  Colon cancer. 2  Ovarian cancer. 3  Stomach cancer. 4  Pancreatic cancer.
1 The cancer itself can make it hard to eat or digest food. 2  This is common in people with cancers of the digestive system, mouth, or throat. 3  Cancer treatments, like radiation therapy and chemotherapy, can cause nausea and a loss of appetite.eople with cancer often need extra calories and protein to support their immune system cells and other tissues. For example, recovery from surgery increases the bodyâs need for nutrients. People with cancer might be poorly nourished for many reasons: 1  The cancer itself can make it hard to eat or digest food.