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Polar molecules are hydrophylic. Because the inner portion of the phospholipid bilayer (plasma membrane) consists of hydrophobic interactions, generally polar molecules cannotâ¦ pass directly though. These molecules require protein channels to actively or passively move between the cytosol and the plasma membrane.
The membrane is selectively permeable because substances do not cross it indiscriminately. Some molecules, such as hydrocarbons and oxygen can cross the membrane. Many large molecules (such as glucose and other sugars) cannot. Water can pass through between the lipids. Ions such as H+ or Na+ cannot.