The DNA samplesare pooled and arrayed in microtiter plates, and thepools are ampliï¬ed using gene-speciï¬c primers. Am-pliï¬cation products are incubated with the CEL Iendonuclease, a member of the S1 nuclease family ofsingle strand-speciï¬c nucleases (Oleykowski et al.,1998).
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