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Caffeine-Related Health Problems. Caffeine increases your heart rate, elevates your blood pressure, and can contribute to the development of heart disease. Both decaf and regular coffee increase your cholesterol and homocysteine, the biochemicals that science has linked to increased risk for heart attack.
There is some concern that combining creatine with caffeine and the herb ephedra (also called Ma Huang) might increase the chance of having serious side effects such as stroke. There is concern that creatine might cause irregular heartbeat in some people. But more information is needed to know if creatine can cause this problem.