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Take pain medication. Taking an over-the-counter medication is one of the most effective ways to make cramps go away. Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and Tylenol work quickly to take away the pain. You can find them in most drug stores.
1 Using Epsom salts in a warm bath may also help relieve cramps. 2  Fill hot water bottle or get a heating pad and place it on the area of your thigh that it cramping. 3  Over the counter heat rubs may also help alleviate muscle cramps and relax the affected area.