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Polar molecules are hydrophylic. Because the inner portion of the phospholipid bilayer (plasma membrane) consists of hydrophobic interactions, generally polar molecules cannotâ¦ pass directly though. These molecules require protein channels to actively or passively move between the cytosol and the plasma membrane.
What molecules can pass directly through the lipid bilayer of a cell membrane, but much more slowly than small nonpolar molecules? Very small polar molecules (ex: water and glycerol) What molecules have very limited permeability?