ESTRING (estradiol vaginal ring) PLACEMENT. The exact position of ESTRING (estradiol vaginal ring) is not critical, as long as it is placed in the upper third of the vagina. When ESTRING (estradiol vaginal ring) is in place, you should not feel anything.he soft, flexible ring is placed in the upper third of the vagina (by the physician or the patient). ESTRING (estradiol vaginal ring) should be removed after90 days of continuous use. If continuation of therapy is indicated, the flexible ring should be replaced.
Fertilization takes place in the fallopian tube, more specifically the juncture of the ampulla and isthmus (ampullary-isthmic junction). The ovaries will ovulate and expel a mature ovum due to a surge in the Leutenizing Hormone.
Once healthy sperm has reached an egg then fertilization can immediately occur. It usually roughly takes 90 seconds for the sperm to reach the egg and can be found in the fallopian tubes within five minutes. So if a woman is ovulating then fertilization can begin immediately and a healthy zygote and begin to form in the womb of the mother.