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Take Synthroid with water only on an empty stomach. Take Synthroid 4 hours before or after. taking iron or calcium supplements, or antacids. Soy, cottonseed meal, walnuts, fiber, and. grapefuit juice can affect the absorption of Synthroid.
Now I try to eat about an hour following the Synthroid but I wait 'til noon or the evening to take the vitamins and supplements. I know this can be a problem if you like to get up, grab a bite to eat and head out the door to work, all in the span of 15 or 20 minutes.