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Take Synthroid with water only on an empty stomach. Take Synthroid 4 hours before or after. taking iron or calcium supplements, or antacids. Soy, cottonseed meal, walnuts, fiber, and. grapefuit juice can affect the absorption of Synthroid.
Summerâ¦it can take a long time for the Synthroid to start working. Like say upwards of 3 months. We do tests for thryoid at my job and our patients have to be off their Synthroid for a minimum of 3 weeks before the test can be done. It takes a long time to get in and out of your system.