The leptin binds with leptin receptors in the hypothalamus and satiety is induced. In the fructose-fed rats, leptin had no effect. Energy intake continued unabated, while normal rats reduced their intake in response to the leptin. Rats on the fructose diet gained even more weight when switched to a high-fat diet. Fructose appears to affect the leptin pathway in two ways. First, fructose directly renders the hypothalamus resistant to leptin.
Step 3: Locate your fuel filter. Filter location depends on the vehicleâs make and model, but one common location is near the fuel tank underneath the chassis. If you have trouble finding the fuel filter, consult your vehicleâs manual or your local repair shop.
If it is a 4 cyl the filter is on thetop of the engine It is a catridge style located in frt of the oil cap down about six inches Black plastic capIn the 6 cyl the filter is at the front of the engine. Also, instead of looking for a large wrench or socket, use a 3/8 ratchet instead (if you are facedâ¦.