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Take pain medication. Taking an over-the-counter medication is one of the most effective ways to make cramps go away. Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and Tylenol work quickly to take away the pain. You can find them in most drug stores.
There's no surefire way to prevent leg cramps, but these tips might help: 1  Don't stand or sit with your legs crossed for long periods of time. 2  Stretch your calf muscles regularly during the day and several times before you go to bed. 3  Rotate your ankles and wiggle your toes whenever you sit down, eat dinner, or watch TV.