Patients with heart failure suffer from swelling because of too much fluid in the body. Furosemide, hydrochlorothiazide, and metolazone are all water pills used to treat the swelling. For most patients, taking furosemide alone is successful. However, sometimes patients need to add another water pill. Doctors usually add either metolazone or hydrochlorothiazide.
Michelangelo was strongly inspired and influenced by ancient Greek and Roman art 4. During the dark ages, European medieval art was exclusively based on Christian themes, due to the lacking number of artists, many artistic techniques and knowledge was lost during this era.
I completely agree that humanism inspired Michelangelo to correctly portray the anatomy in Jesus and Mary. I too was stunned by the detail put into this work, especially the small elements such as the almost realistic fabric and the way Jesus's skin fold under Mary's hand.