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Take pain medication. Taking an over-the-counter medication is one of the most effective ways to make cramps go away. Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and Tylenol work quickly to take away the pain. You can find them in most drug stores.
One of the quickest ways to get rid of side cramps is to massage the area with light pressure. 1  Place your hand on the area that hurts, usually just under your rib cage on one side. 2  Inhale and then as you exhale, use your fingers and thumb to lightly pinch or squeeze this area.