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Insulin resistance can commonly develop if one or more of the following factors apply: 1  If you are overweight or obese. 2  Having a high-calorie diet, high-carbohydrate or high-sugar diet. 3  Sedentary lifestyle â taking little physical activity.  Taking high doses of steroids over an extended period of 1  time. Having chronic stress.
People with insulin resistance need higher levels of insulin to help glucose enter cells. When the beta cells in the pancreas cannot keep up with the demand for insulin, excess glucose builds up in the bloodstream, which leads to serious health disorders like prediabetes and type 2 diabetes.