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Polar molecules are hydrophylic. Because the inner portion of the phospholipid bilayer (plasma membrane) consists of hydrophobic interactions, generally polar molecules cannotâ¦ pass directly though. These molecules require protein channels to actively or passively move between the cytosol and the plasma membrane.
Can Pass Through Bilayer Very small uncharged molecules Molecules which are hydrophobic Although water is polar, it is an exception, it can cross through the phospholipids bilayer because of its small size Non-polar molecules (e.g. lipids) Canât Pass Easily Through Bilayer Ions and charged molecules (e.g. salt dissolved in water) Larger hydrophilic molecules Large polar molecules (e.g. glucose) Tonicity : refers to the relative concentration of solute on either side of the membrane (When ...