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Take pain medication. Taking an over-the-counter medication is one of the most effective ways to make cramps go away. Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and Tylenol work quickly to take away the pain. You can find them in most drug stores.
Additional tips to help relieve muscle cramps: 1  Gently stretch and massage the cramping muscle holding it in stretched position until the cramp stops. 2  Apply heat packs to tense, tight muscles, or ice to sore, tender muscles. 3  Drink plenty of fluids at regular intervals, so as not dehydrate.