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Insulin resistance can commonly develop if one or more of the following factors apply: 1  If you are overweight or obese. 2  Having a high-calorie diet, high-carbohydrate or high-sugar diet. 3  Sedentary lifestyle â taking little physical activity.  Taking high doses of steroids over an extended period of 1  time. Having chronic stress.
The consequence of this so-called insulin resistance is that not enough energy is produced in the cells. Moreover, sugar cannot properly be degraded in the blood and therefore accumulates so that the blood sugar level increases.