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Polar molecules are hydrophylic. Because the inner portion of the phospholipid bilayer (plasma membrane) consists of hydrophobic interactions, generally polar molecules cannotâ¦ pass directly though. These molecules require protein channels to actively or passively move between the cytosol and the plasma membrane.
Polar molecules have trouble passing through the nonpolar part of the phospholipid bilayer. Ions require ion channels and is not as easy as those that simply just diffuse through the membrane. Ion channels might require energy, too... Not glucose because those are larger molecules.