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Insulin resistance can commonly develop if one or more of the following factors apply: 1  If you are overweight or obese. 2  Having a high-calorie diet, high-carbohydrate or high-sugar diet. 3  Sedentary lifestyle â taking little physical activity.  Taking high doses of steroids over an extended period of 1  time. Having chronic stress.
With insulin resistance, the body continues to produce insulin. In fact, as the muscle, fat and liver cells begin not to take in the insulin produced, the body increases its production of insulin in an attempt to get these cells to accept the glucose that begins to build up in the bloodstream.