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Take pain medication. Taking an over-the-counter medication is one of the most effective ways to make cramps go away. Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and Tylenol work quickly to take away the pain. You can find them in most drug stores.
1. Walk it Out. If charlie horse leg cramps occur in the middle of the night when you are sleeping, get out of bed and walk around until the pain goes away. This can be annoying, but this is the easiest approach in getting rid of pain in the leg muscles.