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Grierson-Gopalan syndrome (better known as burning feet syndrome). Consists of severe burning and aching of the feet, hyperaesthesia, pain, elevated skin temperature, and vasomotor changes of the feet, associated with excessive sweating and general body wasting. Ocular complications may include scotoma and amblyopia. Prevalent in women; onset between 20 and 40 years of age.
Many infections can lead to inflammation of the nerves in the legs and feet. The viruses that cause chickenpox and mononucleosis are common culprits. Cytomegalovirus, human immunodeficiency virus, hepatitis B and hepatitis C viruses can trigger intense burning and tingling in the legs and feet as well.