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Take Synthroid with water only on an empty stomach. Take Synthroid 4 hours before or after. taking iron or calcium supplements, or antacids. Soy, cottonseed meal, walnuts, fiber, and. grapefuit juice can affect the absorption of Synthroid.
The body chemistry behind thyroid meds is as follows: Synthroid(T4) : takes 10-14 days to reach blood equilibrium. It then takes on average 2-4 weeks for your physical symptoms to reflect your equilibrated thyroid hormone levels. The closer you are to your optimal thyroid range the quicker you will see/feel results.