If you had a pulmonary embolism (a blood clot in your lungs [PE]), in the past and still have shortness of breath, even after at least 3 months of anticoagulants (blood thinners), you could develop CTEPH.
But that seemed harder when Lip started dating rich girl Amanda (Nichole Bloom), and it got even more complicated when Mandy moved away from Chicago with her abusive boyfriend. But the entrance of Helene (Sasha Alexander), Lip's professor-turned-lover may just be the biggest complication of them all.
Main article: List of Shameless (U.S. TV series) characters. William H. Macy as Frank Gallagher, the father of six children. He is a deadbeat alcoholic who relies on schemes and stealing to survive. He is the biological father of Fiona, Lip, Debbie, Liam, Carl, and Sammiâ but not Ian.