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Take pain medication. Taking an over-the-counter medication is one of the most effective ways to make cramps go away. Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and Tylenol work quickly to take away the pain. You can find them in most drug stores.
Preventing Cramps Using Other Methods. 1  1. Some foods contain vitamins, minerals, and elements that can make your muscles less prone to excessive cramping. 2  2. Get some sun. 3  3. Wait a while after eating before you exercise.