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Latanoprost was the first prostaglandin to be approved as first-line treatment for elevated eye pressure. Three newer prostaglandins are travoprost (Travatan), bimatoprost (Lumigan),and tafluprost (Zioptan). These drugs are used to reduce eye pressure in patients with open-angle glaucoma and high ocular pressure. Side effects include itching, redness, and burning during administration. Muscle and joint pain may also occur.
To treat glaucoma (increased eye pressure), a single dose of five milligrams of THC has been placed under the tongue. A dose of 20-40 milligrams of CBD has been placed under the tongue as a single dose; however, 40 milligrams appeared to increase eye pressure.