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Polar molecules are hydrophylic. Because the inner portion of the phospholipid bilayer (plasma membrane) consists of hydrophobic interactions, generally polar molecules cannotâ¦ pass directly though. These molecules require protein channels to actively or passively move between the cytosol and the plasma membrane.
Transport proteins make passage possible for molecules and ions that would not be able to pass through a plain phospholipid bilayer. Some transport proteins have a hydrophilic tunnel through them which allows polar molecule or ions to pass. Others actually bind to the molecules and move them across the membrane.ome molecules, such as hydrocarbons and oxygen can cross the membrane. Many large molecules (such as glucose and other sugars) cannot. Water can pass through between the lipids. Ions such as H+ or Na+ cannot.