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Short-Term Effects of Heroin. Often injected, the immediate effects of heroin are to modulate pain perception. As a street drug, dosing is impossible to fully control, and the side effects of decreased heart rate and breathing pose immense risk to users.
1 This effect typically only lasts for the first couple of minutes that follow heroin use. 2  What follows is a high that can last for hours and is usually described as a cozy or warm overall feeling. 3  The temporary pleasure derived from heroin use is typically the prime effect that makes people want to use the drug again.any side effects are associated with heroin use. Some of the most common side effects of heroin use include: 1  Skin that is flushed. 2  A mouth that is dry. 3  Extremities that feel heavy.