Patients with renal failure, usually end-stage renal disease (ESRD), commonly are afflicted by severe pruritus. The pathogenesis of ESRD pruritus is unknown, but improving the quality of dialysis can reduce the prevalence and severity of ESRD pruritus.
The earlier generation of Buick Park Avenue ran from 1991 through 1996, with substantial updates for the 1994 model year. It shared its underpinnings with the Oldsmobile 98, that make's largest sedan, as well as a number of Cadillac front-wheel-drive sedans.
Before the establishment of General Motors, GM founder William C. Durant had served as Buick's general manager and major investor. Buick also has the distinction of being the first automobile maker in the world to equip its cars with overhead valve engines, which it did starting in 1904. In 2015, Buick sold 1,231,941 vehicles, a record for the brand. The main market is in China, where 80% of Buick-branded automobiles are sold.