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Take Synthroid with water only on an empty stomach. Take Synthroid 4 hours before or after. taking iron or calcium supplements, or antacids. Soy, cottonseed meal, walnuts, fiber, and. grapefuit juice can affect the absorption of Synthroid.
I have been on Synthroid for 19 months now. I take 175mcg following a TT for cancer. On and off during this time I have missed doses of my meds with no noticable affects. However, over the summer that has changed. I've gone about three times with missing more than one dose in a row - the most was 3 days (out of town).