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What is PUVA? PUVA or photochemotherapy is a type of ultraviolet radiation treatment (phototherapy) used for severe skin diseases. PUVA is a combination treatment which consists of Psoralens (P) and then exposing the skin to UVA (long wave ultraviolet radiation). It has been available in its present form since 1976.
PUVA can potentially cause skin cancer, just as does natural ultraviolet light. In addition, because of the intensity and duration over which it may be given, patients are at greater risk to develop squamous cell skin cancers and melanomas in treated skin than would otherwise be the case.