If you had a pulmonary embolism (a blood clot in your lungs [PE]), in the past and still have shortness of breath, even after at least 3 months of anticoagulants (blood thinners), you could develop CTEPH.
But that seemed harder when Lip started dating rich girl Amanda (Nichole Bloom), and it got even more complicated when Mandy moved away from Chicago with her abusive boyfriend. But the entrance of Helene (Sasha Alexander), Lip's professor-turned-lover may just be the biggest complication of them all.
But all of that will be jeopardized in Season 2 of Shameless when Lip finally reaches his breaking point. It's incredibly frustrating for Lip because he's done so much for the family, and the first time that he asks for any help in return, the family comes up somewhat empty-handed, White told HuffPost TV.