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Polar molecules are hydrophylic. Because the inner portion of the phospholipid bilayer (plasma membrane) consists of hydrophobic interactions, generally polar molecules cannotâ¦ pass directly though. These molecules require protein channels to actively or passively move between the cytosol and the plasma membrane.
C) O2 or Na+ can pass through the bilayer, whereas a fatty acid or H2O cannot. D) H2O or a fatty acid can pass through the bilayer, whereas Na+ or O2 cannot. Three of the following movements across the cell membrane require a protein (either a protein facilitating diffusion or an energy-driven protein pump).