SNAREs are integral membrane proteins (v-SNAREs on vesicles, t-SNAREs on the target organelles) and are thought to provide specificity to the fusion process1â5. It has been suggested that Sec17p and SeclSp bind to v-SNARE/t-SNARE complexes and mediate the membrane fusion event1â3.
In 2015, 4,976 people died in motorcycle crashes, up 8.3 percent from 4,594 in 2014, according to the National Highway Traffic Safety Administration (NHTSA). In 2014, motorcyclists were 27 times more likely than passenger car occupants to die in a crash per vehicle mile traveled, and almost five times more likely to be injured.
About one in three traffic deaths in the United States involve a driver with a blood alcohol concentration (BAC) of 0.08% or higher. Drivers with a BAC of 0.08% or higher (i.e., drunk drivers) are considered alcohol-impaired by law. Thanks to dedicated efforts, rates of drunk driving and alcohol-related fatal crashes have gone down in recent years. Still, drunk drivers got behind the wheel about 121 million times in 2012.