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Take pain medication. Taking an over-the-counter medication is one of the most effective ways to make cramps go away. Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and Tylenol work quickly to take away the pain. You can find them in most drug stores.
Menstrual Cramps - Home Treatment. 1  Use heat, such as hot water bottles, heating pads, or hot baths, to relax tense muscles and relieve cramping. Be careful not to burn yourself.  Drink herbal teas, such as chamomile, mint, raspberry, and blackberry, which may help soothe tense muscles and anxious moods.