The cause of irritable bowel syndrome is unknown. Antibiotic-associated colitis usually occurs in people receiving antibiotics. Inflammatory bowel diseases is a common cause of bowel inflammation and low back pain. There are two major forms: Crohns disease and ulcerative colitis. The causes are unknown. â¢Genetic: There is a high similarity of symptoms among identical twins, particularly with Crohn disease.
An effective dose (ED) in pharmacology is the dose or amount of drug that produces a therapeutic response or desired effect in some fraction of the subjects taking it.D50 [edit]. The median effective dose is the dose that produces a quantal effect (all or nothing) in 50% of the population that takes it (median referring to the 50% population base). It is also sometimes abbreviated as the ED50, meaning effective dose, for 50% of people receiving the drug.
A dose-response model describes the probability of a specified response from exposure to a specified pathogen in a specified population, as a function of the dose. This function is based on empirical data, and will usually be given in the form of a mathematical relationship.. Concurrently with the descriptive analysis of clinical or epidemiological information or data, mathematical modelling has been advocated to provide assistance in developing a dose-response relationship, in particular when extrapolation to low doses is necessary.