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Insulin resistance can commonly develop if one or more of the following factors apply: 1  If you are overweight or obese. 2  Having a high-calorie diet, high-carbohydrate or high-sugar diet. 3  Sedentary lifestyle â taking little physical activity.  Taking high doses of steroids over an extended period of 1  time. Having chronic stress.
Unfortunately, the fallout doesnât end here. Insulin resistance is linked to increased risk of fatty liver disease, gout, polycystic ovary syndrome, memory loss, and some types of cancer. But thereâs an upside. Insulin resistance and metabolic syndrome respond rapidly to lifestyle changes and nutritional therapies.