A Brief Explanation of an Over-the-Counter Market | Definition. A over-the-counter market (OTC) refers to a decentralized and informal way of exchanging stocks, derivatives, or other assets between two parties.
The leading strand is built by using the lagging strand of the old molecule as the template. Replication of the leading strand begins with the enzyme âprimaseâ. Primase adds a small complementary piece of RNA (~10 nucleotides), called an âRNA primerâ, near the end of the lagging strand. The RNA primer gives an enzyme called âDNA polymerase IIIâ something to attach a DNA nucleotide to. A jury-rigged design, RNA primers are necessary because DNA polymerase III can only attach nucleotides to the 3â end of a pre-existing nucleotide.
1 The primer acts as the starting point for DNA synthesis. 2  DNA polymerase binds to the leading strand and then âwalksâ along it, adding new complementary nucleotide bases (A, C, G and T) to the strand of DNA in the 5â to 3â direction. 3  This sort of replication is called continuous.4  Lagging strand: The new strand is proofread to make sure there are no mistakes in the new DNA sequence. 2  Finally, an enzyme called DNA ligase seals up the sequence of DNA into two continuous double strands. 3  The result of DNA replication is two DNA molecules consisting of one new and one old chain of nucleotides.