According to The Hollywood Reporter, the four voice actors who make up the Family Guy cast -- Alex Borstein, Mila Kunis, Seth Green and Mike Henry -- has collectively negotiated a new salary between $175,000 and $225,000 per episode.
Hence, a patient with first degree heart block will typically have a soft first heart sound. For the same reasons a patient with variable PR interval (Mobitz I second degree AV block or third degree heart block) can have changing intensity of the first heart sound. Lyme carditis, anatomically corrected transposition and maternal lupus can all cause complete heart block.
S1 and S2 sounds. The two major sounds of the normal heart sound like lub dub. The lub is the first heart sound, commonly termed S1, and is caused by turbulence caused by the closure of mitral and tricuspid valves at the start of systole. The second heart sound, dub or S2, is caused by the closure of the aortic and pulmonic valves, marking the end of systole. Thus the time period elapsing between the first heart sound and the second sound defines systole (ventricular ejection) and the time between the second sound and the following first sound defines diastole (ventricular filling).