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EmblicaÂ® is a well-defined material, isolated from Phyllanthus emblica (syn. Emblica officinalis) fruits. This tree is native to tropical southeastern Asia, particularly India, Pakistan, Bangladesh, Sri Lanka and southern China. Phyllanthus emblica (known as Indian gooseberry) is one of the most important Ayurvedic ingredients in India and has been used to treat a wide variety of human ailments for thousands of years.
ESBL is a type of B-lactamase that hydrolyzes (inactivates) most extended-spectrum B-lactams (but NOT cephamycins, carbapenems, or B-lactamase inhibitor combinations).Detection and reporting of bacteria that produce extended-spectrum beta-lactamases (ESBLs) present a continuing challenge for the clinical laboratory.-Lactamase is an enzyme that destroys the B-Lactam ring portion of B-Lactam molecules. The following figure shows a simple B-Lactamase reaction depicting hydrolysis of penicillin to penicilloic acid. Penicilloic acid does not have any antibacterial activity.