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Take pain medication. Taking an over-the-counter medication is one of the most effective ways to make cramps go away. Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and Tylenol work quickly to take away the pain. You can find them in most drug stores.
A light sheet will help reflect some of your body heat back to you, and warm muscles are much less likely to cramp. 1  In winter, use a covered hot water bottle to place near the area of your legs that cramps most often. 2  Try a warm shower if mid-cramp. 3  Very hot water can get rid of cramps if you stay in it for a while.