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Take Synthroid with water only on an empty stomach. Take Synthroid 4 hours before or after. taking iron or calcium supplements, or antacids. Soy, cottonseed meal, walnuts, fiber, and. grapefuit juice can affect the absorption of Synthroid.
Yes - you describe classic symptoms and labs for too much synthroid (or any thyroid replacement medication). It may take 2-4 weeks to start to see improvement in symtpoms and 6-8 weeks (or more) to see the TSH normalize (and confirm that 125mcg is adequate for you).