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How It Works. Leflunomide (Arava) is a disease-modifying antirheumatic drug (DMARD) that is used to treat rheumatoid arthritis. It interferes with the progression of the disease by blocking the production of white blood cells that cause the joint inflammation in rheumatoid arthritis.
Cimzia (also known by its generic name certolizumab pegol) is a biologic medication approved in September 2013 by the FDA for the treatment of active psoriatic arthritis. It is also approved for treating rheumatoid arthritis and Crohn's disease. Cimzia is given by injection under the skin. The recommended dose for psoriatic arthritis is 400 milligrams (given as two injections of 200 milligrams each) initially and at week two and week four, followed by a dose of 200 milligrams every other week.