The thirteenth-century accomplishments of Chinggis Khan in conquering a swath of the world from modern-day Korea to southern Russia and in invading deep into Europe, and the cultural achievements of his grandson, Khubilai Khan, in China are well-known in world history.
Extra fluid can be removed by kidneys to form urine.When kidneys shut down, the fluids will build up in body, thus leading to swelling. It often cause retention of fluids in legs and feet. In serious case, the lung may be flooded with water. Swelling is one of common symptoms of kidney shutdown.
In some cases, the immune response over-reacts, turning cytokines against the body they are designed to protect. When the cytokine cascades fail to shut down, they drive the host into a state of chronically activated cells, which dominate an otherwise dormant immune system. Examples of the most obvious manifestations of this hypersensitivity are an unnecessary inflammatory response and fever, both of which can be life threatening if left untreated.