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Insulin resistance can commonly develop if one or more of the following factors apply: 1  If you are overweight or obese. 2  Having a high-calorie diet, high-carbohydrate or high-sugar diet. 3  Sedentary lifestyle â taking little physical activity.  Taking high doses of steroids over an extended period of 1  time. Having chronic stress.
Points to Remember. 1  Insulin is a hormone that helps cells throughout the body absorb glucose and use it for energy. Insulin resistance is a condition in which the body produces insulin but does not use it effectively. 2  Insulin resistance increases the risk of developing type 2 diabetes and prediabetes. Prediabetes usually occurs in people who already have insulin resistance. Although insulin resistance alone does not cause type 2 diabetes, it often sets the stage for the disease by placing a high demand on the insulin-producing beta cells. In prediabetes, the beta cells can no longer produce enough insulin to overcome insulin resistance, causing blood glucose levels to rise above the normal range. Once a person has prediabetes, continued loss of beta cell function usually leads to type 2 diabetes. People with type 2 diabetes have high blood glucose.