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Drug-induced hypothyroidism may be caused by: 1  Drugs used for hyperthyroidism (overactive thyroid), such as propylthiouracil (PTU), radioactive iodine, potassium iodide, and methimazole. 2  Treatment with lithium or iodides in certain people.
If it does, over time people with silent thyroiditis may develop long-term hypothyroidism. If you're already being treated for a thyroid problem, and your thyroid function begins to shift between underactive and overactive, thyroiditis probably isn't the source of the problem. More likely, your medication is to blame. People diagnosed with hyperthyroidism usually take the medication methimazole to prevent the thyroid from producing excess hormones. This medication sometimes can initially decrease hormone production too much, and hypothyroidism results.