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The proximal tubules make up a significant portion of the kidneys; proximal tubule epithelial cells are the most populous cell type in the kidney, and carry out diverse regulatory and endocrine functions where numerous transporters are located.he proximal tubules make up a significant portion of the kidneys; proximal tubule epithelial cells are the most populous cell type in the kidney, and carry out diverse regulatory and endocrine functions where numerous transporters are located.
These cells in the kidney line the epithelial lining of the convoluted tubule. They lie in close proximity to the juxtaglomerular cells. Angiotensinogen. This is an alpha 2 glycoprotein that is synthesised in the liver and is split by Renin at the Leu-Val bond to form Angiotensin I.