Theoretically, it is possible that diphenhydramine could affect a woman's milk supply, since the medication can suppress prolactin (a hormone important for breast milk production). However, this is probably not an issue for women who are well-established with breastfeeding.
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proÂ·tagÂ·oÂ·nist. n. 1. The main character in a drama or other literary work. 2. In ancient Greek drama, the first actor to engage in dialogue with the chorus, in later dramas playing the main character and some minor characters as well. 3. a. A leading or principal figure.