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Take pain medication. Taking an over-the-counter medication is one of the most effective ways to make cramps go away. Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and Tylenol work quickly to take away the pain. You can find them in most drug stores.
Of course, if you wake up with a leg cramp, a bananaâs not going to do you much good, so here are some tips to relieve cramps immediately: 1  Apply a hot compress to the cramped muscles. 2  Massage the cramped muscles. 3  Stretch and flex.