In advance of the Monday release of his book, Steve Jobs: A Biography, Isaacson told the CBS News program  60 Minutes  that Jobs said he initially felt the surgery would be too invasive.
The HandiHaler device is an inhalation device used to inhale the dry powder contained in the SPIRIVA capsule. The dry powder is delivered from the HandiHaler device at flow rates as low as 20 L/min. Under standardized in vitro testing, the HandiHaler device delivers a mean of 10.4 mcg tiotropium when tested at a flow rate of 39 L/min for 3.1 seconds (2L total).
AtroventÂ® is available for use as a metered dose inhaler and in a solution for a nebulizer. SpirivaÂ® is available for use in a HandiHalerÂ®. Like short-acting beta agonists (e.g. albuterol), they are bronchodilators, relaxing the muscle bands around the airways. However, short-acting beta agonists relax the muscle bands after they are already tight. Ipratropium bromide (AtroventÂ®) and Tiotropium bromide (SpirivaÂ®) prevent the muscle bands from tightening. For that reason, they are controller medicines.