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What is PUVA? PUVA or photochemotherapy is a type of ultraviolet radiation treatment (phototherapy) used for severe skin diseases. PUVA is a combination treatment which consists of Psoralens (P) and then exposing the skin to UVA (long wave ultraviolet radiation). It has been available in its present form since 1976.
PUVA is used to treat moderate to severe plaque psoriasis that has not responded to topical treatments, or UVB therapy. PUVA can be more successful on thicker plaques of psoriasis than UVB, as the UVA is absorbed deeper in the skin. For the same reason, hand and foot psoriasis is often treated with PUVA therapy. Like UVB, PUVA is given in a phototherapy unit and administered by a team of health professionals.