The leptin binds with leptin receptors in the hypothalamus and satiety is induced. In the fructose-fed rats, leptin had no effect. Energy intake continued unabated, while normal rats reduced their intake in response to the leptin. Rats on the fructose diet gained even more weight when switched to a high-fat diet. Fructose appears to affect the leptin pathway in two ways. First, fructose directly renders the hypothalamus resistant to leptin.
Step 3: Locate your fuel filter. Filter location depends on the vehicleâs make and model, but one common location is near the fuel tank underneath the chassis. If you have trouble finding the fuel filter, consult your vehicleâs manual or your local repair shop.
The evap purge solenoid is located on the top of the engine. The evap vent solenoid is located in the rear drivers side wheel well, attached to the charcoal canister.here is one solenoid on the charcoal evap. canister in the engine compartment. There is another one located near the gas tank underneath the chassis. That is the one that usu â¦ ally goes bad as road salt and moisture attack that one.