1 The portion of the brain that maintains the bodyâs internal balance (homeostasis). 2  The hypothalamus is the link between the endocrine and nervous systems. 3  The hypothalamus produces releasing and inhibiting hormones, which stop and start the production of other hormones throughout the body.
In the mid-19th century the Industrial Revolution began to change Spain. The first railway in Spain was built in 1848 and by the 1860s railways had spread across Spain. Mining and the iron and steel industries in Spain grew in the late 19th century.
As the sponsor of Christopher Columbus's voyages, Spain was the first European power to settle and colonize the largest areas, from North America and the Caribbean to the southern tip of South America.Spanish cities were founded as early as 1496 with Santo Domingo in today's Dominican Republic.he first phase of well-financed European activity in the Americas began with the Atlantic Ocean crossings of Christopher Columbus (1492â1504), sponsored by Spain, whose original attempt was to find a new route to India and China, known as  the Indies .