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Symptoms of primary coccidioidomycosis, in decreasing order of frequency, include fever, cough, chest pain, chills, sputum production, sore throat, and hemoptysis. Physical signs may be absent or limited to scattered rales with or without areas of dullness to percussion over lung fields.
Signs of coccidiosis are usually worst following stressful periods such as weather changes, weaning, overcrowding, long travel, filthy surroundings or other illnesses such as shipping fever. In mild cases, animals may be asymptomatic, or may only show mild diarrhea, and exhibit a rough haircoat .