If you had a pulmonary embolism (a blood clot in your lungs [PE]), in the past and still have shortness of breath, even after at least 3 months of anticoagulants (blood thinners), you could develop CTEPH.
But that seemed harder when Lip started dating rich girl Amanda (Nichole Bloom), and it got even more complicated when Mandy moved away from Chicago with her abusive boyfriend. But the entrance of Helene (Sasha Alexander), Lip's professor-turned-lover may just be the biggest complication of them all.
In Season 2, she went to Debbieâs birthday party just because Lip was going to be there. Holly tried to have sex with Lip, but he refused to have sex with her, so Holly ran away to begin her career as a prostitute.