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Insulin resistance can commonly develop if one or more of the following factors apply: 1  If you are overweight or obese. 2  Having a high-calorie diet, high-carbohydrate or high-sugar diet. 3  Sedentary lifestyle â taking little physical activity.  Taking high doses of steroids over an extended period of 1  time. Having chronic stress.
Insulin resistance, long associated with type 2 diabetes and a known risk factor for heart disease, occurs when the body does not properly use insulin to metabolize blood glucose, or sugar. The condition results when insulin fails to enable cells to admit glucose, necessary for cells' energy production.