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However, sadness, depression, grief, or anxiety are a common cause of weight loss that is not explained by other factors, especially among the elderly. Cancer may also cause decreased appetite. You may lose weight without trying. Cancers that may cause you to lose your appetite include: 1  Colon cancer. 2  Ovarian cancer. 3  Stomach cancer. 4  Pancreatic cancer.
1 Unexplained weight loss: Lack of appetite or unexplained weight loss is a common sign of cancer.  Stomach pain: Abdominal discomfort or pain in the abdomen above the navel could be a symptom of stomach cancer. Also, swelling or fluid build-up in the abdomen may also be caused by stomach cancer.