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Take Synthroid with water only on an empty stomach. Take Synthroid 4 hours before or after. taking iron or calcium supplements, or antacids. Soy, cottonseed meal, walnuts, fiber, and. grapefuit juice can affect the absorption of Synthroid.
7-10 days: For the effects of the steroid medication to take effect and it may be up to 7-10 days before the maximum benefits are achieved.