The system, to be established by the US Securities and Exchange Commission (SEC) and the North American Securities Administrators Association (NASAA)(1), will be based on technology used in the new Web-based Central Registration Depository (CRD) coming on line later this month.
Minivelle is currently the smallest estrogen patch available at 2.48cm 2 per patch (about 34% smaller than Vivelle-Dot). Minivelle contains bioidentical estradiol, a plant-based estrogen that is chemically identical to the estrogen produced naturally by a woman's body.
Whereas inflammation and cytokine production is common to all three types, intimal calcification is characterized by subintimal lipid deposition and macrophage accumulation, whereas in medial calcification, metabolite-induced (toxic) vascular changes in the absence of lipid deposits are regarded as specifically leading to upregulation of osteogenic regulatory genes that then induce osteogenic differentiation of mesenchymal cells with subsequent matrix mineralization, bone, and cartilage ...