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Short-Term Effects of Heroin. Often injected, the immediate effects of heroin are to modulate pain perception. As a street drug, dosing is impossible to fully control, and the side effects of decreased heart rate and breathing pose immense risk to users.
Physical and Mental Effects of Heroin. Soon after use, heroin causes a rush or surge of pleasurable sensation. The intensity depends on how the drug is taken, how pure it is and how much tolerance to the drug a person has developed. Injecting heroin provides the biggest rush.n addict will refer to this as âgetting well.â There is no rush of euphoria in this situation. The person is just coping with the urgent need for the drug and is not able to get enough of the drug to get high. The other effects of heroin include: 1  Warm flush. 2  Dry mouth. 3  Heavy feeing in the extremities. 4  Nausea. 5  Vomiting.