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Take Synthroid with water only on an empty stomach. Take Synthroid 4 hours before or after. taking iron or calcium supplements, or antacids. Soy, cottonseed meal, walnuts, fiber, and. grapefuit juice can affect the absorption of Synthroid.
Best Answer: Hello, I've been synthroid or over 5 years now for hypothyroidism. I felt better pretty quickly when i first started taking it. (like in 3 weeks.) But had to take some time to find the right level of the medicine. We had to re-evaluate after I was on it for 3-6 months and see how much i really needed.ow long does it take for thyroid medicine to work? I have started taking thyroxine for hypothyroidism one month ago, but have not yet noticed any improvement in symptoms.