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How It Works. Leflunomide (Arava) is a disease-modifying antirheumatic drug (DMARD) that is used to treat rheumatoid arthritis. It interferes with the progression of the disease by blocking the production of white blood cells that cause the joint inflammation in rheumatoid arthritis.
Leflunomide is taken orally as a tablet. Daily dosing of leflunomide in patients with RA typically ranges from 10 mg to 20 mg. Your doctor will determine which dose is appropriate for you based on how well you tolerate and respond to the medication.