Chromosome instability usually leads to tumorigenesis. Bloom syndrome (BS) is a genetic disease associated with chromosome instability. The BS gene product, BLM, has been reported to function in the spindle assembly checkpoint (SAC) to prevent chromosome instability.
Flight time from Detroit to Chicago is usually between 45 minutes to one hour.
How long is the flight between Detroit MI and Honolulu HI?   A typical flight between Detroit, MI and Honolulu, HI would have a flying time of about 8 hours, 58 minutes.