Related articles: Deck, Landscape Design, Sod. 1  Prices for underground sprinkler systems vary considerably by region and climate, but for an average 2,500-square-foot (50-x-50-foot) front yard, it's about $1,500-$2,500, while a sprinkler system for 5,000 square feet (front and back yards) costs about $2,500-$3,500.
Mitochondrial DNA depletion syndrome. Mitochondrial DNA depletion syndrome (MDS) refers to a group of autosomal recessive disorders which cause the affected tissues to suffer from a significant drop in mitochondrial DNA. Symptoms may manifest as myopathic, hepatopathic, and/or encephalomyopathic.
Mitochondrial disorders are a clinically heterogeneous group of conditions that are typically the result of mitochondrial respiratory chain dysfunction, which is essential for aerobic metabolism. Mitochondrial disorders can be caused by mutations of mitochondrial DNA or nuclear DNA. Each human cell contains thousands of copies of mitochondrial DNA and usually, all copies are identical genetically, which is referred to as homoplasmy. Individuals with mitochondrial disorders may have a mixture of mutant and normal mitochondrial DNA within each cell, also known as heteroplasmy.