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Calf muscle pain can be due to injury, underlying medical condition or a problem in the nerves or arteries in the lower leg. Whilst often something minor like a grade one muscle strain, the problem may not actually be in the muscle itself and could be indicative of a serious problem such as a DVT so should always be treated with caution.
This differs a bit from calf pain from causes other than cramping that results in muscle spasm. Exercise-related cramps are likely caused by muscle fatigue and may involve the Golgi tendon bodies, which normally fire to inhibit the muscle from contracting too hard. If the Golgi body fatigues, the nerve input to the muscle is overstimulated and the muscle cramps.