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Silver sulfadiazine (INN, or silvadene) is a topical sulfonamide / silver antibacterial used as a topical cream on burns.Evidence regarding its usefulness in burns is poor.Tentative evidence has found that silver sulfadiazine may increase healing times â wounds may take longer to heal if treated with this drug, so it is not recommended by the authors of a Cochrane review.Silver sulfadiazine is typically delivered in a cream or aqueous suspension.entative evidence has found that silver sulfadiazine may increase healing times â wounds may take longer to heal if treated with this drug, so it is not recommended by the authors of a Cochrane review.
Cream/Ointment/Lotion Formulations. Silver sulfadiazine is for external use only. Do not use if cream has darkened in color. Apply to cleansed, debrided, burned areas using a sterile-gloved hand. Apply to a thickness of approx. = 1.6 mm (1/16th of an inch).