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Erythrocyte deformability refers to the ability of erythrocytes (red blood cells, RBC) to change shape under a given level of applied stress, without hemolysing (rupturing).rythrocyte deformability is an important determinant of blood viscosity, hence blood flow resistance in the vascular system. It affects blood flow in large blood vessels, due to the increased frictional resistance between fluid laminae under laminar flow conditions.
Mean corpuscular hemoglobin concentration and cell deformability. Clark MR. Department of Laboratory Medicine, University of California, San Francisco 94143. A prominent characteristic of sickle cells is the presence of a subpopulation of severely dehydrated cells.Apart from its effect on the rate and extent of Hb S polymerization at low oxygen tension, dehydration has adverse effects on deformability of oxygenated sickle cells.In general, the degree of deformability defect induced by cellular dehydration measured in vitro depends on the method used to measure deformability.part from its effect on the rate and extent of Hb S polymerization at low oxygen tension, dehydration has adverse effects on deformability of oxygenated sickle cells. In general, the degree of deformability defect induced by cellular dehydration measured in vitro depends on the method used to measure deformability.