Related articles: Deck, Landscape Design, Sod. 1  Prices for underground sprinkler systems vary considerably by region and climate, but for an average 2,500-square-foot (50-x-50-foot) front yard, it's about $1,500-$2,500, while a sprinkler system for 5,000 square feet (front and back yards) costs about $2,500-$3,500.
Mitochondrial DNA depletion syndrome. Mitochondrial DNA depletion syndrome (MDS) refers to a group of autosomal recessive disorders which cause the affected tissues to suffer from a significant drop in mitochondrial DNA. Symptoms may manifest as myopathic, hepatopathic, and/or encephalomyopathic.
These genetic diseases include mtDNA depletion syndromes such as Alpers or early infantile hepatocerebral syndromes, and mtDNA deletion disorders, such as progressive external ophthalmoplegia (PEO), ataxia-neuropathy, or mitochondrial neurogastrointestinal encephalomyopathy (MNGIE).his review focuses on our current knowledge of genetic defects of mtDNA replication (POLG, POLG2, C10orf2) and nucleotide metabolism (TYMP, TK2, DGOUK, and RRM2B) that cause instability of mtDNA and mitochondrial disease. PMCID: PMC3244805. [PubMed-indexed for MEDLINE].