Load Fund. What is a 'Load Fund'. A load fund is a mutual fund that comes with a sales charge or commission. The fund investor pays the load, which goes to compensate a sales intermediary, such as a broker, financial planner or investment advisor, for his time and expertise in selecting an appropriate fund for the investor.
When levels of glycogen in the liver are very low, such as when you are fasting or on a low-carbohydrate diet, the liver uses alternative sources to produce and release more glucose into the bloodstream. Through a process called gluconeogenesis, the liver can create glucose from amino acids, the building blocks of protein and fat byproducts.
Insulin is a hormone produced by the pancreas that controls glucose levels in blood by reducing the amount of glucose made by the liver and by increasing the removal of glucose from the blood by muscle and fat tissues. As a result, insulin causes blood glucose levels fall. Diabetes caused by a decrease in production of insulin that causes increased production of glucose by the liver, and reduced uptake (and effects) of insulin on fat and muscle tissues. Metformin acts by increasing the sensitivity of liver, muscle, fat, and other tissues to the uptake and effects of insulin.