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In the. stomach, alcohol interferes with gastric acid secretion and with the activity of the. muscles surrounding the stomach. Similarly, alcohol may impair the muscle. movement in the small and large intestines, contributing to the diarrhea frequently.
Medications like ibuprofen can cause liver problems, even if you don't drink alcohol at the same time and especially if you take the drug on an empty stomach. Alcohol can also do damage to the liver, so the combination can really harm your liver. If you take ibuprofen with alcohol, you can get ulcers of the stomach that are severely painful. The pain is not a superficial type of pain but is a deep visceral pain from damage to your internal organs. You can begin to have bleeding inside the stomach, especially if you take more than two drinks with ibuprofen.