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I wear them at least 12 hours each day and they are still fine at the 12 hour mark! I used to wear the advance and the oasys contacts are much better! I haven't had any problems at all and would recommend this brand. Lens.com also has the best price for the Acuvue Oasys contact lenses (and I searched around!).
Do not use this medication while you are wearing contact lenses. Polymyxin B and trimethoprim ophthalmic may contain a preservative that can be absorbed by soft contact lenses and cause discoloration. Wait at least 15 minutes after using polymyxin B and trimethoprim ophthalmic before putting your contact lenses in.