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Answers. Best Answer: Primary nondisjunction can happen during meiosis when the chromosomes fail to separate as they should. This produces gametes with more than or less than the usual number of chromosomes. Secondary nondisjunction happens during meiosis in an individual whose chromosomes are already the wrong number because of nondisjunction. So, primary nondisjunction could produce a gamete with two Xs and a zygote with XXY. When this person matures and produces gametes, secondary nondisj.
Nondisjunction is the failure of homologous chromosomes or chromatids to segregate during mitosis or meiosis. Nondisjunction during mitosis can result in cancer. Nondisjunction during meiosis results in one daughter cell having both of a pair of parental chromosomes with the other having none. It causes a mutation in the number of chromosomes, either extra chromosomes or missing chromosomes. Nondisjunction during meiosis can cause chromosomal disorders, such as trisomy 21 (Down syndrome), Turner's syndrome, and Klinefelter's syndrome.