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In the. stomach, alcohol interferes with gastric acid secretion and with the activity of the. muscles surrounding the stomach. Similarly, alcohol may impair the muscle. movement in the small and large intestines, contributing to the diarrhea frequently.
However, alcohol can worsen side effects caused by some antibiotics, like dizziness or an upset stomach. You should definitely avoid drinking alcohol while taking metronidazole (Flagyl), as this combination can cause severe nausea and vomiting.