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The side effects of some types of medication and drugs can affect your fertility. These medicines are outlined below. 1  Non-steroidal anti-inflammatory drugs (NSAIDs) . 2  Long-term use or a high dosage of NSAIDs, such as ibuprofen or aspirin, can make it more difficult for you to conceive.3  Chemotherapy.nfertility is most commonly caused by problems with ovulation (the monthly release of an egg). Some problems stop women releasing eggs at all, and some cause an egg to be released during some cycles, but not others. Ovulation problems can occur as a result of many conditions, such as:
9 Not all NSAIDs have the samepotential to cause peptic ulcer disease, infact ibuprofen in low doses (up to 1200mgdaily) is said to have the same Odds Ratio 2 as paracetamol in causing uppergastrointestinal bleeding. 7 Diclofenac alsohas a low odds ratio although higher thanthat for ibuprofen.