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White matter is located at the base of the brain between the cerebellum and the brainstem. It is made of long nerve fibers called axons. The axons are insulated by myelin, sheaths of fat that give the region the white color for which it is named. The myelin helps speed up the transmission of signals along the axons.
1 Gray matter located on the surface of the brain is called cortex (e.g., cortex of the cerebral hemispheres, cortex of the cerebellum). 2  Masses of gray matter located deeper in the brain are called nuclei .(e.g., brainstem nuclei, nuclei of the thalamus).yramidal cells are the efferent (long-axon) cells of the cerebral cortex. The name refers to the shape of the cell body as seen in standard sections perpendicular to the cortical surface. The apex of the pyramid points toward the cortical surface.