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What do I need to know about Vitamin K, if I am taking warfarin (Coumadin)? Changes in the amount of vitamin K in the diet can alter the metabolism of warfarin (Coumadin Â®). However, vitamin K does not influence the action of other blood thinners, such as heparin or low molecular weight heparins (Lovenox Â®. Fragmin Â®, or Innohep Â®).
Warfarin and related 4-hydroxycoumarin-containing molecules decrease blood coagulation by inhibiting vitamin K epoxide reductase, an enzyme that recycles oxidized vitamin K 1 to its reduced form after it has participated in the carboxylation of several blood coagulation proteins, mainly prothrombin and factor VII.