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Description of Trazodone. Trazodone: oral antidepressant (trade name Desyrel) that is a nontricyclic drug used as a sedative. Trazodone: A synthetic triazolopyridine derivative, antidepressant and sedative Trazodone acts as a serotonin uptake inhibitor, chemically unrelated to tricyclic, tetracyclic, or other antidepressants.
First are dose-response studies. The dose of trazodone needed to induce and maintain sleep is not well understood. Thus, clinicians use anywhere from 25 mg to 150 mg taken at bedtime as a hypnotic dose. This is a critical question because it is recognized that at high doses these medications carry a high safety risk.