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The other breakthrough in MDS, which Dr. List was involved with, was the development of lenalidomide (Revlimid, Celgene) as the first targeted agent for the disease. Lenalidomide, which is an immunomodulator used in the treatment of multiple myeloma, was approved by the FDA in 2005 for use in a subset of patients with MDS. The specific indication was patients with low-risk or intermediate-1 risk MDS with a deletion 5q cytogenetic abnormality.