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gist - the central meaning or theme of a speech or literary work. 2. gist - the choicest or most essential or most vital part of some idea or experience; the gist of the prosecutor's argument; the heart and soul of the Republican Party; the nub of the story.
GIST was introduced as a diagnostic term in 1983. Until the late 1990s, many non-epithelial tumors of the gastrointestinal tract were called gastrointestinal stromal tumors. Histopathologists were unable to specifically distinguish between types we now know to be dissimilar molecularly.