Warfarin (Coumadin) is sometimes prescribed as a blood thinner because it is an effective vitamin K antagonist (blocks the formation of vitamin K). The activated partial thromboplastin time (PTT) measures the function of several other clotting factors, found in the intrinsic and common blood clotting pathways.
Etruscans and the early Roman monarchy made several contributions to the Roman republic. The establishment of Rome was through Romulus and Remus. Through legends, they were thought to be abandoned by their uncle, and raised up by a she wolf.
According to tradition and later writers such as Livy, the Roman Republic was established around 509 BC, when the last of the seven kings of Rome, Tarquin the Proud, was deposed by Lucius Junius Brutus and a system based on annually elected magistrates and various representative assemblies was established.