Signs and symptoms of peripheral neuropathy might include: 1  Gradual onset of numbness, prickling or tingling in your feet or hands, which can spread upward into your legs and arms.  Sharp, jabbing, throbbing, freezing or burning pain.
Case Study of Adjacent Segment Disease. A patient with a 2-year-old anterior cervical discectomy and fusion at the c5-c6 level presents with pain in the neck, or cervical spine, increased with movement. MRI findings indicate clinically significant disc disease in the levels adjacent to the cervical fusion at C4-C5 and C6-C7.
Elevated levels of antibodies to RNP are seen in mixed connective tissue disease. In SLE, RNP antibodies have been associated with a relatively benign disease course with lower incidence of renal and central nervous system involvement.Patients may be considered positive for RNP antibodies when the RNP antibody result is significantly higher than the Sm antibody result.ntibodies to Sm are highly specific for systemic lupus erythematosus (SLE) and when present are considered a marker antibody. However, these antibodies are found in only 20% of patients with SLE.