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Anyone wanting to trade aha insights feel free to do it in this thread. I welcome as many people as are interested to join me here in trading cool bits of insight. Here's one: Why do thiazides and loop diuretics cause hyperglycemia? Because they lower serum [K+], thereby depolarizing the beta-cell and inhibiting insulin secretion. In effect, low serum [K+] has the opposite effect on the ATP-sensitive K-channel that SUR's have. Maybe that's in First Aid, I don't know... It just dawned on me and I thought I would share.
â  Signs and symptoms of hyperkalemia may occur even when potassium-sparing diuretics are combined with thiazide diuretics. Hyperkalemia occurs in approximately 10% of patients when amiloride is used alone and may occur in up to 26% of patients receiving spironolactone even when combined with thiazide diuretics.