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Ultimately, most baristas agree that the best grind size is the one that results in a shot that pulls in 23 to 29 seconds and (Very important!) tastes great. To grind coffee beans for espresso, fill the hopper and activate the grinder for about 15 to 20 seconds.
Here is what it was like for a woman who ingested 50,000 mg of caffeine, the equivalent of drinking 250 strong shots of espresso: A 27-year-old woman with a history of depression and previous overdose presented within 60 min of ingestion of 50 g of caffeine powder.