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Silver sulfadiazine (INN, or silvadene) is a topical sulfonamide / silver antibacterial used as a topical cream on burns.Evidence regarding its usefulness in burns is poor.Tentative evidence has found that silver sulfadiazine may increase healing times â wounds may take longer to heal if treated with this drug, so it is not recommended by the authors of a Cochrane review.Silver sulfadiazine is typically delivered in a cream or aqueous suspension.entative evidence has found that silver sulfadiazine may increase healing times â wounds may take longer to heal if treated with this drug, so it is not recommended by the authors of a Cochrane review.
It is effective against many gram-positive and gram-negative organisms. It acts on the cell membrane and cell wall. Silver sulfadiazine is typically delivered in a 1% solution suspended in a water-soluble base. Usage. Silver sulfadiazine is used primarily as a topical burn cream on second and third degree burns in horses. It prevents the growth of a wide array of bacteria, as well as yeast, on damaged skin. It is also helpful on other shallow, large area wounds such as abrasions.