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Which Vaccinations for South Africa May I Need? The exact shots for South Africa will depend on your personal health history and the location of your safari. The World Health Organization generally recommends the following vaccines: 1  Yellow Fever. 2  Typhoid. 3  Hepatitis A. 4  Hepatitis B. 5  Rabies. 6  Routine Vaccinations.
Routine Shots. Routine vaccinations aren't just for children -- they protect adults as well from potentially serious illnesses. The U.S. Centers for Disease Control and Prevention recommends that American travelers have a diphtheria/pertussis/tetanus, or DPT, measles/mumps/rubella, or MMR, and poliovirus vaccine.