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The side effects of some types of medication and drugs can affect your fertility. These medicines are outlined below. 1  Non-steroidal anti-inflammatory drugs (NSAIDs) . 2  Long-term use or a high dosage of NSAIDs, such as ibuprofen or aspirin, can make it more difficult for you to conceive.3  Chemotherapy.nfertility is most commonly caused by problems with ovulation (the monthly release of an egg). Some problems stop women releasing eggs at all, and some cause an egg to be released during some cycles, but not others. Ovulation problems can occur as a result of many conditions, such as:
No Changes in Sperm HealthAmong the 68 patients who reported taking ibuprofen regularly in a three-month period prior to their semen analyses, there were no differences in the health of their sperm compared to those who reported using the drug either intermittently or not at all, the study found.rostaglandins are proteins that promote inflammation in the body as part of the immune response.2 As such, medications like ibuprofen that fall in a class of medicines known as non-steroidal anti-inflammatory drugs, or NSAIDs (EN-seds) inhibit the production of prostaglandins in the body.