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The forms of human malaria caused by other Plasmodium species cause significant morbidity but are rarely life-threatening. Cases of severe P. vivax malaria have recently been reported among populations living in (sub)tropical countries or areas at risk. P. vivax and P. ovale can remain dormant in the liver. Relapses caused by these persistent liver forms (âhypnozoitesâ) may appear months, and rarely several years, after exposure.
1 P. malariae, found worldwide, is the only human malaria parasite species that has a quartan cycle (three-day cycle). ( 2 The three other species have a tertian, two-day cycle.) If untreated, P. malariae causes a long-lasting, chronic infection that in some cases can last a lifetime. P. falciparum can cause severe malaria because it multiples rapidly in the blood, and can thus cause severe blood loss (anemia). 2  In addition, the infected parasites can clog small blood vessels. 3  When this occurs in the brain, cerebral malaria results, a complication that can be fatal.