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gist - the central meaning or theme of a speech or literary work. 2. gist - the choicest or most essential or most vital part of some idea or experience; the gist of the prosecutor's argument; the heart and soul of the Republican Party; the nub of the story.
Top Definition. gib. 1(n) of 3D computer games, a fragment esp. a gobbet of flesh resulting from total obliteration of a target usually by means of an explosion; giblet. 2(v trans.) to cause massive damage to a target, to the point of obliteration. abbreviation from giblet. Spootonium gibbed amigdala.