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Confidence votes 24. No, while the Titanic and its tragedy were real, Jack and Rose are simply fictional characters. There was a trimmer aboard name John Dawson who died when the ship sank, but this is purely coincidental. Besides, he was Irish and his name was John.
Jack Thayer, who was 17 when he survived the Titanic (and is not portrayed in ITV's drama), killed himself in 1945 when he was 50 by slitting his wrists and throat, after losing both his son Edward during the Second World War and his mother Marian Thayer (a Titanic survivor herself).