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Which Vaccinations for South Africa May I Need? The exact shots for South Africa will depend on your personal health history and the location of your safari. The World Health Organization generally recommends the following vaccines: 1  Yellow Fever. 2  Typhoid. 3  Hepatitis A. 4  Hepatitis B. 5  Rabies. 6  Routine Vaccinations.
Routine Vaccinations; Is Malaria In South Africa? Malaria is present in South Africa and carries a fairly high risk in the northern parts of the country. Speak with a travel health specialist to learn more about whether you need antimalarials and what type is right for you. According to the CDC, South Africa also has the following mosquito-borne diseases: Dengue Fever; Chikungunya