Historical Examples. 1  He was quick at repartee, and his observations were gentle but pertinent. 2  We quote for the sake of one line chiefly, but the whole stanza is pertinent. 3  His reply was curt and pertinent: It took long enough, young man!. 4  Gertrude's earnestness was too real to be shaken by this pertinent inquiry.
Explore Disease States. TTP Thrombotic Thrombocytopenic Purpura. Thrombotic Thrombocytopenic Purpura (TTP) is a rare, life-threatening disorder of the blood-coagulation system which causes microscopic clots to form in small blood vessels throughout the body. Although itâs rare, TTP affects about 4 to 6 people per million per year, most often women and African-Americans.
A lack of activity in the ADAMTS13 enzyme (a type of protein in the blood) causes TTP. The ADAMTS13 gene controls the enzyme, which is involved in blood clotting. The enzyme breaks up a large protein called von Willebrand factor that clumps together with platelets to form blood clots.