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Which Vaccinations for South Africa May I Need? The exact shots for South Africa will depend on your personal health history and the location of your safari. The World Health Organization generally recommends the following vaccines: 1  Yellow Fever. 2  Typhoid. 3  Hepatitis A. 4  Hepatitis B. 5  Rabies. 6  Routine Vaccinations.
Talk to your doctor about what vaccines you might need for your trip. Based on your destination and planned activities, you might need some, all, or none of the vaccines discussed in this section. Tetanus, hepatitis A, typhoid, and polio are all single-dose vaccines. However, if you are leaving soon, your body might not have time to develop protection after the shot, so you should follow your doctorâs advice for reducing your risk of these diseases.