1 Rules of navigation in the water area of the Northern Sea Route Ministry of Transport of Russia, January 17, 2013. 2  International Northern Sea Route Programme. 3  Russian State Museum of the Arctic and Antarctic, The discovery and history of exploration of the Northern Sea Route. 4  Pictures - during NE passage.
Symptoms of estrogen deficiency in postmenopausal women include vaginal dryness and itching, urethritis & cystitis (commonly known as urethra or bladder infection), high blood pressure, fractures, bone pain, foot and leg cramps, osteoporosis, facial hair growth, skin wrinkles, hot flashes, brain fog (loss of concentration and forgetfulness), and ...
Estrogen deficiency can lead to lack of menstruation (amenorrhea), persistent difficulties associated with menopause (such as mood swings and vaginal dryness), and osteoporosis in older age. In cases of estrogen deficiency, natural and synthetic estrogen preparations may be prescribed. Estrogen is also a component of many oral contraceptives. An overabundance of estrogen in men causes development of female secondary sexual characteristics (feminization), such as enlargement of breast tissue.