The Property and Casualty Group is among the oldest in the United States, dating from the founding of our flagship company, Great American Insurance Company, in 1872. The P&C Group is made up of approximately 30 niche specialty insurance industries that focus on specialized commercial products and services for businesses.
autoimmune disease definition. A disease in which the body produces antibodies that attack its own tissues, leading to the deterioration and in some cases to the destruction of such tissue. Discover our greatest slideshows.
For other uses, see Aire. The autoimmune regulator (AIRE) is a protein that in humans is encoded by the AIRE gene. AIRE is a transcription factor expressed in the medulla of the thymus and controls the mechanism that prevents the immune system from attacking the body itself.Each T cell attacks a foreign substance presented within a MHC molecule which it identifies with its receptor.he autoimmune regulator is mutated in the rare autoimmune syndrome Autoimmune Polyendocrinopathy Syndrome type 1 (APS-1), also known as Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED).