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Description of Trazodone. Trazodone: oral antidepressant (trade name Desyrel) that is a nontricyclic drug used as a sedative. Trazodone: A synthetic triazolopyridine derivative, antidepressant and sedative Trazodone acts as a serotonin uptake inhibitor, chemically unrelated to tricyclic, tetracyclic, or other antidepressants.
Ironically, Trazodone is not a controlled substance like Ambien and Lunesta which are also prescribed for insomnia. Trazodone abuse is perhaps a direct result of it being a drug that is easier to get.razodone Abuse Is Growing Worldwide. Trazodone is an antidepressant that causes extreme drowsiness. Today, it is more often prescribed as a sleep aid, than as an antidepressant. Trazodone abuse has also grown; it is one the top 20 drugs abused in the US today.