Chromosome instability usually leads to tumorigenesis. Bloom syndrome (BS) is a genetic disease associated with chromosome instability. The BS gene product, BLM, has been reported to function in the spindle assembly checkpoint (SAC) to prevent chromosome instability.
Flight time from Detroit to Chicago is usually between 45 minutes to one hour.
It depends on the flight you're taking. You can check the flight time when you are booking-you can see the number of layovers and how long the layovers are. I went to Hawaii from Grand Rapids, Mi and it took about 15 hours with about 1.5 hrs layover in Chicago. The shortest flight from the Midwest to Hawaii is about 12-13 hours. Have fun in Hawaii...it is heaven on Earth.