The looping of the template for the lagging strand enables a dimeric DNA polymerase III holoenzyme at the replication fork to synthesize both daughter strands. (Courtesy of A. Kornberg. From L. Stryer, Biochemistry, 4th ed.he 3â²âââ5â² exonuclease action of DNA polymerase III. Note that this exonuclease activity takes place at the 3â² end of the growing strand (and is therefore 3â²âââ5â²). The coordination of exonuclease activity with strand growth helps to explain why replication is in the 5â²âââ3â² direction.
McAllen is the twenty-first most populous city in Texas and the largest city in Hidalgo County, Texas. It is located at the southern tip of Texas in the Rio Grande Valley (not a geographical valley) and is part of the Southern United States.
Like other border towns, the area has a dominant Hispanic heritage, high growth rate, and a low cost of living. McAllen is in the center of a broad, flat agricultural area known locally as âThe Valleyâ dotted with vegetable and citrus growing interspersed with small towns and expanding suburbs.