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Answers. Best Answer: Primary nondisjunction can happen during meiosis when the chromosomes fail to separate as they should. This produces gametes with more than or less than the usual number of chromosomes. Secondary nondisjunction happens during meiosis in an individual whose chromosomes are already the wrong number because of nondisjunction. So, primary nondisjunction could produce a gamete with two Xs and a zygote with XXY. When this person matures and produces gametes, secondary nondisj.
Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate properly during cell division. There are three forms of nondisjunction: failure of a pair of homologous chromosomes to separate in meiosis I, failure of sister chromatids to separate during meiosis II, and failure of sister chromatids to separate during mitosis. Nondisjunction results in daughter cells with abnormal chromosome numbers (aneuploidy).