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Which Vaccinations for South Africa May I Need? The exact shots for South Africa will depend on your personal health history and the location of your safari. The World Health Organization generally recommends the following vaccines: 1  Yellow Fever. 2  Typhoid. 3  Hepatitis A. 4  Hepatitis B. 5  Rabies. 6  Routine Vaccinations.
Some vaccines may also be required for travel. Routine vaccines: Make sure you are up-to-date on routine vaccines before every trip. These vaccines include measles-mumps-rubella (MMR) vaccine, diphtheria-tetanus-pertussis vaccine, varicella (chickenpox) vaccine, polio vaccine, and your yearly flu shot. Most travelers. Get travel vaccines and medicines because there is a risk of these diseases in the country you are visiting. Hepatitis A