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Description of Trazodone. Trazodone: oral antidepressant (trade name Desyrel) that is a nontricyclic drug used as a sedative. Trazodone: A synthetic triazolopyridine derivative, antidepressant and sedative Trazodone acts as a serotonin uptake inhibitor, chemically unrelated to tricyclic, tetracyclic, or other antidepressants.
All of the low-dose sedating antidepressants have half-lives greater than the usual sleep period. Even trazodone, the shortest-acting of these drugs and the least sedating, at a dose of 50 mg is associated with reports of daytime somnolence in 23% of patients compared with 8% for placebo. The prevalence of daytime somnolence is higher at higher doses, in elderly patients, and for tricyclic antidepressants.