Definition of retraction. Examples of retraction in a sentence. His charges were false, and he was forced to make a retraction. Then, last spring, Gabriel Arana, an editor at The American Prospect who had undergone several years of reparative therapy in his teens, called on Spitzer at his home in Princeton, New Jersey.
2010]. Grapefruit juice inhibited the first-pass metabolism of oxycodone by CYP3A4 enzymes in the liver; consequently, oxycodone plasma concentrations were significantly increased by 50% and the half-life was extended by 20%.
Firstly, grapefruit juice contains furanocoumarins (such as 6â²,7â²-dihydroxybergamottin),3 which can cause irreversible inhibition of the cytochrome P450 enzyme, CYP3A4, mainly in the small intestine.4 CYP3A4 is involved in the metabolism of around 50% of drugs, so a wide variety of drugs can be affected by the consumption of grapefruit juice.