Chromosome instability usually leads to tumorigenesis. Bloom syndrome (BS) is a genetic disease associated with chromosome instability. The BS gene product, BLM, has been reported to function in the spindle assembly checkpoint (SAC) to prevent chromosome instability.
Flight time from Detroit to Chicago is usually between 45 minutes to one hour.
The shortest one stop flight from Detroit to Atlanta to Paris is 12 hrs and 24 minutes with an hour and 47 minute layover in Atlanta The shortest non-stop is 8.5 hours.