Its analgesic effects are only partially reversed by naloxone, hence indicating that its opioid action is unlikely the sole factor; tramadol's analgesic effects are also partially reversed by Î±2 adrenergic receptor antagonists like yohimbine and the 5-HT3 receptor antagonist, ondansetron.
Array formulas in versions before Excel 2007 cannot handle whole-column references. In Excel 2007, array formulas can handle whole-column references, but this forces calculation for all the cells in the column, including empty cells. This can be slow to calculate, especially for 1 million rows.
Most Excel files are small enough not to affect performance, but size isn't the only thing that can slow things down. Fortunately, you don't have to know all about multithreads and dual processors to eliminate bad performance.