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What do I need to know about Vitamin K, if I am taking warfarin (Coumadin)? Changes in the amount of vitamin K in the diet can alter the metabolism of warfarin (Coumadin Â®). However, vitamin K does not influence the action of other blood thinners, such as heparin or low molecular weight heparins (Lovenox Â®. Fragmin Â®, or Innohep Â®).
Vitamin A interferes with absorption of vitamin K, and large doses of vitamin E decrease vitamin Kâdependent clotting factors, thus promoting bleeding. Toxicity from food is rare, because the body excretes vitamin K much more rapidly than other fat-soluble vitamins.oxicity. High doses of vitamin K can reduce the effectiveness of anticoagulant drugs such as warfarin (Coumadin), which is used to prevent blood clotting. People taking these drugs should maintain a consistent daily intake of vitamin K. Megadose supplements of vitamin A and E can pose a risk to vitamin-K status.