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Which Vaccinations for South Africa May I Need? The exact shots for South Africa will depend on your personal health history and the location of your safari. The World Health Organization generally recommends the following vaccines: 1  Yellow Fever. 2  Typhoid. 3  Hepatitis A. 4  Hepatitis B. 5  Rabies. 6  Routine Vaccinations.
What To Think About. Twinrix should not be given to people who are allergic to the contents of the vaccine. To get the best protection before travel, you need 2 doses of Twinrix before departure. But if you can get only 1 dose, consider getting just the hepatitis A vaccine instead of 1 shot of combination vaccine.hat To Think About. Twinrix should not be given to people who are allergic to the contents of the vaccine. To get the best protection before travel, you need 2 doses of Twinrix before departure. But if you can get only 1 dose, consider getting just the hepatitis A vaccine instead of 1 shot of combination vaccine.