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A set peak inspiratory pressure (PIP) is applied, and the pressure difference between the ventilator and the lungs results in inflation until the peak pressure is attained and passive exhalation follows. The delivered volume with each respiration is dependent on the pulmonary and thoracic compliance.
Since the esophageal pressure reflects the intrapleural pressure, this method is considered accurate. In standing posture, the effect of gravity on intrapleural pressure can be seen. There is a gradient from the basal part of lungs to the apex, with the apex showing more negative pressure (â 10 mmHg) and the basal part having less negative pressure (â 2 mmHg). Thatâs why, the apical portion has more resting volume of air, but less ventilated, as compared to the basal part of lungs.