Various conditions can lead to irritated, red skin. Causes can range from a temporary sensitivity to a chronic skin problem. Common culprits of red skin or red spots include: 1  Dry skin. 2  Sunburn. 3  Rosacea. 4  Acne. 5  Allergic contact dermatitis. 6  Eczema (atopic dermatitis).
Methylene blue is a component of a frequently prescribed urinary analgesic/anti-infective/anti-spasmodic known as Prosed, a combination of drugs which also contains phenyl salicylate, benzoic acid, hyoscyamine sulfate, and methenamine (aka hexamethylenetetramine and not to be confused with 'methanamine').
Methylene blue was administered orally to pregnant rats at doses of 50 to 350 mg/kg/day, during the period of organogenesis. Maternal and embryofetal toxicities were observed at all doses of methylene blue, and were most evident at the 200 and 350 mg/kg/day doses.