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Sclerodermaâs main types are localized and systemic. Localized means the disease affects only certain parts of the body. Systemic means it can affect the whole body. 1  The localized type often affects only skin tissues. 2  It does not harm major organs.3  It may get better or go away without help.4  But it can be severe in some people and can leave skin damage.ocalized means the disease affects only certain parts of the body. Systemic means it can affect the whole body. 1  The localized type often affects only skin tissues. 2  It does not harm major organs. 3  It may get better or go away without help. 4  But it can be severe in some people and can leave skin damage.
Sederma. Deep Wrinkle Treatment With Dermaxylâ¢ and Matrixylâ¢ 3000 (Formulation #SC-345) is a formulation that features products supplied by Croda. This high performance cream utilizes two of Sedermaâs latest anti-aging ingredients, Dermaxylâ¢ and Matrixylâ¢ 3000, for their synergistic effect against wrinkles. Crodafosâ¢ CES further enhances the efficacy of these actives by promoting the simultaneous release of both the water and oil based actives from the emulsion.