Definition of retraction. Examples of retraction in a sentence. His charges were false, and he was forced to make a retraction. Then, last spring, Gabriel Arana, an editor at The American Prospect who had undergone several years of reparative therapy in his teens, called on Spitzer at his home in Princeton, New Jersey.
2010]. Grapefruit juice inhibited the first-pass metabolism of oxycodone by CYP3A4 enzymes in the liver; consequently, oxycodone plasma concentrations were significantly increased by 50% and the half-life was extended by 20%.
One or more substances in grapefruit and grapefruit juice block the action of an enzyme called cytochrome P-450 3A4 (CYP3A4). This enzyme breaks down a wide array of medications, including atorvastatin (Lipitor). (For an extensive list of drugs affected by grapefruit juice, visit health.harvard.edu/165.) Knocking CYP3A4 out of action means higher blood levels of these medications. One glass of grapefruit juice, or eating half a grapefruit, is enough to suppress CYP3A4 activity by half, and the effect lasts up to 24 hours.