Less serious side effects include: 1  Loss of appetite. 2  Weight loss. 3  Nausea. 4  Vomiting. 5  Diarrhea. 6  Frequent urination. 7  Muscle cramps, painful and swollen joints. 8  Excessive tiredness. 9  Difficulty falling asleep. 10  Headache, nervousness, dizziness. 11  Depression, mood swings. 12  Vivid dreams.
Nausea can occur in dogs for many reasons, particularly when the digestive tract and nervous systems are out of balance. Stress can certainly play a role in nausea.
A dog with a tendency toward diabetes may have a temporary diabetic reaction which can become permanent with prolonged use of prednisone. There may be a tendency to nausea and other signs of upset stomach with the use of pred in a dog with an existing sensitive stomach.