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Prednisone is prescribed for a client with diabetes mellitus who is taking Humulin NPH insulin daily. Which prescription change does the nurse anticipate during therapy with the prednisone? a) An additional dose of prednisone daily b) A decreased amount of daily Humulin NPH insulin c) An increased amount of daily Humulin NPH insulin d) The addition of an oral hypoglycemic medication daily Pharmacology NCLEX Practice Questions Answers and Rationale 31) C
Twice-daily administration of NPH insulin and regular insulin usually works adequately while endogenous insulin is still being produced. Two thirds of the total daily insulin dose may be given 20 to 30 minutes before breakfast, and one third of the dose may be given 20 to 30 minutes before the evening meal. As an estimate, NPH insulin and regular insulin can be given in a 2:1 ratio for the breakfast dose and a 1:1 ratio for the evening-meal dose.