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The classical site of muscarinic receptors is at the postganglionic parasympathetic neuroeffector junction in smooth muscle, heart, and exocrine glands. However, muscarinic receptors also exist on effectors cells, even in the absence of cholinergic innervation.Prototype agonists include muscarine and ACh.he classical site of muscarinic receptors is at the postganglionic parasympathetic neuroeffector junction in smooth muscle, heart, and exocrine glands. However, muscarinic receptors also exist on effectors cells, even in the absence of cholinergic innervation. Prototype agonists include muscarine and ACh.
The main function of muscarinic receptors is to act as the main end-receptor stimulated by acetylcholine, which is released from the postganglionic fibers in the parasympathetic nervous system. Nicotinic Receptor. Nicotinic receptors are commonly noted as nAChRs.It is also a type of acetylcholine receptor.Like muscarinic receptors sensitive to muscarine, nicotinic receptors are sensitive to nicotine. The class of receptors to which nicotinic receptors belong is called ionotropic receptors.Ionotropic receptors have a quite different mechanism compared to metabotropic receptors. These receptors do not use G-proteins.ike muscarinic receptors sensitive to muscarine, nicotinic receptors are sensitive to nicotine. The class of receptors to which nicotinic receptors belong is called ionotropic receptors. Ionotropic receptors have a quite different mechanism compared to metabotropic receptors. These receptors do not use G-proteins.