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Cowden syndrome is a disorder characterized by multiple noncancerous, tumor-like growths called hamartomas and an increased risk of developing certain cancers. Almost everyone with Cowden syndrome develops hamartomas.
Bannayan-Riley-Ruvalcaba syndrome; Cowden disease; Cowden syndrome; multiple hamartoma syndrome; proteus-like syndrome; General Discussion. The PTEN hamartoma tumor syndrome (PHTS) is a spectrum of disorders caused by mutations of the PTEN gene. These disorders are characterized by multiple hamartomas that can affect various areas of the body.