Furthermore, the protestant John Knox and Mary of Guise's half-brother James Stuart were stirring Scotland up against the Church of Rome, a situation which the King of France could not allow to continue. Thus Henry I gave his consent and the public marriage document was signed on 19th April 1558.
Critical Limb Ischemia (CLI) Critical Limb Ischemia (CLI) is a severe obstruction of the arteries which markedly reduces blood flow to the extremities (hands, feet and legs) and has progressed to the point of severe pain and even skin ulcers or sores. The pain caused by CLI can wake up an individual at night.
Ischemia, also spelled as ischaemia or ischaemia (/ischÃ¦mia/), ÉªËskiËmiÉ is a restriction in blood supply to, tissues causing a shortage of oxygen and glucose needed for cellular (metabolism to keep tissue). Alive ischemia is generally caused by problems with blood, vessels with resultant damage to or dysfunction of. tissueschemia is generally caused by problems with blood vessels, with resultant damage to or dysfunction of tissue. It also means local anemia in a given part of a body sometimes resulting from congestion (such as vasoconstriction, thrombosis or embolism).