Seen as quite offensive for some, especially older groups and British Asian females, with its sexual connotations. For others it is seen as a middle of the road sort of word. Most offensive word to majority, and never really acceptable (though some might occasionally use).
Cyclins go hand in hand with kinases. Cyclins do not cause a cell to progress in the cell cycle because cyclins are mere proteins that regulate the rate of the process, and how fast the cell progresses through this process. Cyclins also act by binding to various kinases, which are enzymes that transfer a phosphate group from ATP to other enzymes. The phosphate group activates these enzymes. The quantity of these kinases in the cell remains steady throughout the cell cycle; however they are active only when bound to cyclins.
Cyclin D / CDK4, Cyclin D / CDK6, and Cyclin E / CDK2 â regulates transition from G 1 to S phase. G 2 /M cyclins â essential for the control of the cell cycle at the G2/M transition . G 2 /M cyclins accumulate steadily during G 2 and are abruptly destroyed as cells exit from mitosis (at the end of the M-phase).