Overall, filibustering and U.S. policies seem to have hindered more than helped U.S. attempts at territorial expansion in this time period. The Gadsden Purchase was the only official territorial acquisition during the 1850s.
Acellular pertussis vaccines were introduced nation-wide in Sweden in 1996, 17 years after the withdrawal of whole-cell pertussis vaccine from the childhood immunisation schedule.he annual incidence of culture-confirmed B. pertussis was 89-150 per 100,000 before introduction of acellular pertussis vaccines and has dropped to 17-26 per 100,000. The data suggest that unimmunised infants and children who have received only one dose of pertussis vaccine were provided some protection.
The first pertussis. vaccine was developed in the 1930s and was in. widespread use by the mid-1940s, when pertussis. vaccine was combined with diphtheria and tetanus. toxoids to make the combination DTP vaccine.