Confidence votes 11. According to Wikipedia, the width of the Atlantic Ocean at its narrowest point is 2,848 kilometers (1,770 mi) between Brazil and Sierra Leone.
What causes PNH? It is not fully understood why people develop PNH. Inside the bone marrow, blood cells are made by stem cells (the seed cells of the marrow). PNH occurs due to a change (or mutation) in a gene in one of the stem cells in the bone marrow. This mutation happens in a gene called PIG-A and the cells made by this stem cell lack certain proteins on their surface making them âweakerâ than normal blood cells.
1 Ongoing hemolysis is the root cause of the signs, symptoms, and serious health problems of PNH 2,4. 2  A simple blood testA test done to look at parts of the blood. 3  Examples of tests include complete blood count (CBC), LDH, and high-sensitivity flow cytometry.t can also lead to signs and symptoms like 2,4 1  : FatigueTiredness, trouble concentrating, dizziness, and weakness to the point where even normal, everyday activities become a struggle. 2  In PNH, fatigue is often out of proportion to the amount of anemia, as measured by hemoglobin, because it is affected by hemolysis.