Furthermore, the protestant John Knox and Mary of Guise's half-brother James Stuart were stirring Scotland up against the Church of Rome, a situation which the King of France could not allow to continue. Thus Henry I gave his consent and the public marriage document was signed on 19th April 1558.
Critical Limb Ischemia (CLI) Critical Limb Ischemia (CLI) is a severe obstruction of the arteries which markedly reduces blood flow to the extremities (hands, feet and legs) and has progressed to the point of severe pain and even skin ulcers or sores. The pain caused by CLI can wake up an individual at night.
Clinical events that cause acute limb ischemia include acute thrombosis of a limb artery or bypass graft, embolism from the heart or a diseased artery, dissection, and trauma (from severing of an artery or thrombosis). Acute thrombosis of a limb artery is most likely to occur at the site of an atherosclerotic plaque.