Often, for gene transcription to occur, a number of transcription factors must bind to DNA regulatory sequences. This collection of transcription factors, in turn, recruit intermediary proteins such as cofactors that allow efficient recruitment of the preinitiation complex and RNA polymerase.ranscription factors use a variety of mechanisms for the regulation of gene expression. These mechanisms include: 1  stabilize or block the binding of RNA polymerase to DNA. 2  catalyze the acetylation or deacetylation of histone proteins.
The best time to take this, and other statin anti-cholesterol meds, is about 6pm in the evening. This has nothing to do with meals. Rather, it's best to get the drug in your â¦ system when cholesterol is being made in the body by the liver, which occurs between 6pm and midnight.+ 3 others found this useful.he best time to take this, and other statin anti-cholesterol meds, is about 6pm in the evening. This has nothing to do with meals. Rather, it's best to get the drug in your â¦ system when cholesterol is being made in the body by the liver, which occurs between 6pm and midnight. + 3 others found this useful.
Firstly, the bigger part of the bodyâs cholesterol is produced by the liver at night, the process being the most intensive in fasting hours early in the morning. Thus, taking simvastatin before going to bed coincides with the time when your body most needs assistance in rebutting cholesterol.