Aminoglycosides are excreted by glomerular filtration and have a serum half-life of 2 to 3 h; the half-life increases exponentially as the GFR falls (eg, in renal insufficiency, in the elderly).
Madagascar is the world's major natural vanilla producer, accounting for about 75% of production. Cloves are the third main export crop, grown mostly by smallholders. Production follows a 4-year cycle with 2â3 years of high output followed by one year of low production.
In 1883, France invaded Madagascar and by 1896 had established rule over the island, which became a French colony. France used Madagascar as a source for timber and exotic spices, like vanilla. The Malagasy had two major uprisings against the French, in 1918 and 1947, but the country did not gain independence until June 26, 1960.