Furthermore, the protestant John Knox and Mary of Guise's half-brother James Stuart were stirring Scotland up against the Church of Rome, a situation which the King of France could not allow to continue. Thus Henry I gave his consent and the public marriage document was signed on 19th April 1558.
Critical Limb Ischemia (CLI) Critical Limb Ischemia (CLI) is a severe obstruction of the arteries which markedly reduces blood flow to the extremities (hands, feet and legs) and has progressed to the point of severe pain and even skin ulcers or sores. The pain caused by CLI can wake up an individual at night.
Ischemia (Definition). Ischemia is a symptom in which a person does not have enough blood supply to a part of the body, making that part of the body ischemic. For example, in a heart attack, a coronary artery is blocked so blood cannot get to the heart muscle beyond the blockage point. The heart muscle lacking blood supply has ischemia. ...Read more.