Per general etiquette, the mother of the bride buys her wedding day outfit first, then notifies the mother of the groom about the color, length and overall formality of her choice. But if the groom's mom doesn't get word by the four-month mark, she should touch base with the bride-to-be about what to do.
Genetics. The two main types of hemophilia are caused by gene mutations that affect the levels of clotting factors in the blood. Mutation of the FVIII gene leads to hemophilia A, also called classic hemophilia, while a mutations in the FIX gene leads to hemophilia B, also called Christmas disease.
Rating Newest Oldest. Best Answer: A good example of a small genetic change resulting in a major genetic disorder is hemophilia, a collection of disorders in which the human body is unable to clot properly making it difficult for those individuals to stop bleeding once a blood vessel has been broken.emophilia A, the most common form, is caused by a mutation in the F8 gene which codes for clotting Factor VIII (the mutation is recessive so the individual must be homozygous for it to be expressed).