Continue cooking about 50-80 minutes or until the meat registers 145 degrees on a meat thermometer. Some roasts are long and thin and others are short and fat, consequently the cooking times will vary depending on the shape of your roast. The meat thermometer is the best way to judge the right amount of cooking time.
Endophthalmitis is an inflammation of the inside of the eye. Inflammation affects the vitreous fluid in center of the eye. Vitreous fluid is a clear, gel-like substance. The inflammation can extend to surrounding tissues responsible for vision. Endophthalmitis is rare. In most cases, an infection triggers this inflammation.
Do not talk (or cough, or sneeze) while preparing or performing the intravitreal injection, as Dr. McCannel from UCLA showed at AAO (Chicago 2010) that the most common source of the bacteria causing endophthalmitis was from the surgeon's mouth.