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The classical site of muscarinic receptors is at the postganglionic parasympathetic neuroeffector junction in smooth muscle, heart, and exocrine glands. However, muscarinic receptors also exist on effectors cells, even in the absence of cholinergic innervation.Prototype agonists include muscarine and ACh.he classical site of muscarinic receptors is at the postganglionic parasympathetic neuroeffector junction in smooth muscle, heart, and exocrine glands. However, muscarinic receptors also exist on effectors cells, even in the absence of cholinergic innervation. Prototype agonists include muscarine and ACh.
Thus, the receptors to which both acetylcholine and muscarine can attach are called muscarinic.. Of the five known subtypes, M4 and M5 are restricted to the brain. The subtypes associated with the ANS are M1, M2 and M3. Binding of acetylcholine to M1 and M3 receptors causes an increase the activity of the cell. Binding of acetylcholine to M2 receptors causes a decrease the activity of the cell.