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CVS is usually performed between 10 and 13 weeks from your last menstrual period. CVS may be chosen over amniocentesis because it may be performed earlier in the pregnancy. Chorionic villus sampling detects chromosome abnormalities (i.e. Down syndrome) and genetic disorders (i.e. cystic fibrosis.).
The diagnostic procedures available for prenatal diagnosis of Down syndrome are chorionic villus sampling (CVS) and amniocentesis. These procedures, which carry up to a 1% risk of causing a spontaneous termination (miscarriage), are practically 100% accurate in diagnosing Down syndrome. Amniocentesis is usually performed in the second trimester after 15 weeks of gestation, CVS in the first trimester between 9 and 11 weeks.