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Caffeine withdrawal symptoms typically appear 12 to 24 hours after abstaining from coffee, and peak within 24 to 48 hours. They include: headache; lethargy and drowsiness; depressed mood; anxiety; nausea; vomiting; muscle pain and stiffness; and inability to concentrate.
Updated April 04, 2016. Withdrawal nausea and vomiting are uncomfortable and unpleasant symptoms that occur among people who have been addicted to some drugs, particularly alcohol and opiates, or even after a period of intense substance use.