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Caffeine withdrawal symptoms typically appear 12 to 24 hours after abstaining from coffee, and peak within 24 to 48 hours. They include: headache; lethargy and drowsiness; depressed mood; anxiety; nausea; vomiting; muscle pain and stiffness; and inability to concentrate.
In fact, coffee enemas sometimes used in colon cleansing have been linked to several deaths. Colon cleansing can also cause less serious side effects, such as cramping, bloating, nausea and vomiting. Other concerns with colon cleansing are that it can: 1  Increase your risk of dehydration. 2  Lead to bowel perforations.