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When Milan was the capital of the west, it surpassed Rome in importance because the imperial court was there. Christianity was made the state religion of the empire with the Edict of Milan. Two fathers of the Catholic church worked in Milan.
In the Maccabean period we are told that Judas and Jonathan both took it and purified it of idolatry (1 Maccabees 5:68; 10:84). In these passages it is called Azotus, as it is also in the New Testament (Acts 8:40). In the 4th century A.D. it became the seat of a bishopric. It had been restored in the time of Herod, by the Roman general Gabinius, and was presented to Salome, the sister of Herod, by the emperor Augustus.