The most common causes of CKD do not cause any pain. And, much of the pain that is near the kidneys is not caused by a kidney problem. But some people who have CKD do have pain. Some people with kidney problems may have pain in the upper back (where the kidneys are) or on the same side as the affected kidney.he most common causes of CKD do not cause any pain. And, much of the pain that is near the kidneys is not caused by a kidney problem. But some people who have CKD do have pain. Some people with kidney problems may have pain in the upper back (where the kidneys are) or on the same side as the affected kidney.
Diuretics are used to treat disorders such as hypertension and several types of edema that are caused by conditions such as heart failure and cirrhosis of the liver. However, use of diuretics can lead to complications, including dehydration and electrolyte imbalances. The action of carbonic anhydrase inhibitors reduces the rate of hydrogen ion secretion and there reabsorption of bicarbonate ions. The bicarbonate ions increase tubular osmotic pressure, causing osmotic diuresis. With long-term use, the diuretic effects of carbonic anhydrase inhibitors tends to be lost.
As diuretics increase the removal of salts from the blood, they also cause more water to be drawn out of the blood and into the urine. Furosemide is used to treat conditions where excess fluid has been retained in the body (oedema). For example, in heart failure, the pumping mechanism of the heart is less effective. This can cause fluid to build up in the ankles, causing swelling, and the lungs (pulmonary oedema), which makes it difficult to breathe.