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Assessment of Depression in Advanced Illness. What Symptoms to Look for and How to Assess. Somatic symptoms (e.g., changes in appetite, weight, energy level, libido, or sleeping) are almost invariably present in patients with advanced illness.
In addition, according to the DSM-5 -- a manual used to diagnose mental health conditions -- you may have other symptoms with major depression. Those symptoms might include: Fatigue or loss of energy almost every day. Feelings of worthlessness or guilt almost every day.