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Biochemistry of Dog Coat Color. The color of a dogâs coat is determined by relative levels of two pigments: eumelanin, which can be either brown or black, and pheomelanin, which is yellow to orange or red. Both pigments are generated by metabolism of tyrosine. A schematic diagram of the pathway is below. Schematic of the melanin synthesis pathways.
The skin and coat of a dog may sometimes change color or become lighter or darker. This may be a normal process, or may be due to a serious disease. If the skin or coat has a color other than white, it is said to be 'pigmented.' Colors include brown, black, red, purple, and yellow. If the skin is a darker color than normal, it is said to be 'hyperpigmented.' The table below provides a list of the majority of the conditions, which are associated with pigment change.