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Myopathy is a disease of muscle in which the muscle fibers do not function properly. This results in muscular weakness. Myopathy simply means muscle disease (Greek myo- muscle + patheia < -pathy suffering). This meaning implies that the primary defect is within the muscle, as opposed to the nerves (neuropathies or neurogenic disorders) or elsewhere (e.g., the brain).
By Dr Tomislav MeÅ¡troviÄ, MD, PhD. Myopathies are a group of disorders characterized by a primary structural or functional impairment of skeletal muscle.They usually affect muscle without involving the nervous system, resulting in muscular weakness.yopathies can manifest with either ânegativeâ or âpositiveâ symptoms. Negative symptoms include muscle weakness, exercise intolerance and fatigue, while so called positive symptoms usually encompass cramps and myalgias, with occasional contractures, myotonia and myoglobinuria.