Ono Pharmaceuticals, Opdivo âs originator, has negotiated a price of Â¥150,200 ($1,459) per 20mg vial of Opvido, and Â¥729,849 for 100mg.pplying a similar mark-up to Opdivo, as well as accounting for the higher average body weight of 75kg in the US, gives a price for Opdivo of $118,000 per patient per year, if the same assumption is made about time on therapy.
*Philosophes did not support democracy. -George III of England (r. 1760-1820) and Louis XV of France (r. 1715-1774) had no interest in enlightened monarchy. -Catherine the Great of Russia, Frederick the Great of Prussia, and Joseph II of Austria were Europe's best-known enlightened despots.
While Louis XIV justified his absolute authority by appealing to the divine right of kings, the enlightened absolutists justified their absolute authority by proclaiming themselves servants of the state or the people.