Aminoglycosides are excreted by glomerular filtration and have a serum half-life of 2 to 3 h; the half-life increases exponentially as the GFR falls (eg, in renal insufficiency, in the elderly).
Madagascar is the world's major natural vanilla producer, accounting for about 75% of production. Cloves are the third main export crop, grown mostly by smallholders. Production follows a 4-year cycle with 2â3 years of high output followed by one year of low production.
Agriculture in Madagascar is heavily influenced by the island's rainfall, which is generally abundant on the whole East coast, decreases sharply on the highlands, and falls to less than 500 mm per year in the South and South-West. The main growing season starts with the first rains in October â November.