Side Effects. Side effects are rare; still symptoms like ear irritation, acute inflammation of the ear canal and pinna are reported. In some cases the pet might experience lack of appetite, vomiting, diarrhea, or hearing loss during the course of treatment, which might require immediate medical aid.
Furthermore, if the median age of a marathon participant is about 40, then the average maximum heart rate of a U.S. marathoner is about 180. Seventy percent of 180 is 126, while 80 percent is 144. Therefore, the heart rate of a mid-pack runner during a marathon is near the middle of the range -- between 126 and 144, or 135 beats per minute.
The aerobic zone represents a harder running effort at 70 to 80 percent of your max heart rate. For the 32-year-old, his aerobic heart rate zone would be 188 (max) x .70 = 132 and 188 x .80 = 150. This runner's average range aerobic heart rate zone stays between 132 to 150 beats per minute.