1 For example, the disorder sickle cell anaemia is caused by a mutation in the gene that instructs the building of a protein called haemoglobin. 2  This causes the red blood cells to become an abnormal, rigid, sickle shape. 3  However, in African populations, having this mutation also protects against malaria.
Optimistic time - generally the shortest time in which the activity can be completed. It is common practice to specify optimistic times to be three standard deviations from the mean so that there is approximately a 1% chance that the activity will be completed within the optimistic time.
The simplest and fastest way to update activity progress is to use the duration % complete type. The remaining duration is automatically computed based on the duration % complete input. If you have an activity that has a non-uniform production rate then physical % complete is the Percent Complete Type of choice. In this Percent Complete Type both the % complete and remaining duration must be input. If you are manufacturing parts then the units % complete type may be used to describe manufactured units completed.