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Assessment of Depression in Advanced Illness. What Symptoms to Look for and How to Assess. Somatic symptoms (e.g., changes in appetite, weight, energy level, libido, or sleeping) are almost invariably present in patients with advanced illness.
Some possible symptoms of depression include: 1  A persistent sad, anxious, or empty mood. 2  Feelings of hopelessness and pessimism. 3  Feelings of guilt, worthlessness, and helplessness. 4  Loss of interest or pleasure in hobbies and activities that were once enjoyed, including sex.