Furthermore, the protestant John Knox and Mary of Guise's half-brother James Stuart were stirring Scotland up against the Church of Rome, a situation which the King of France could not allow to continue. Thus Henry I gave his consent and the public marriage document was signed on 19th April 1558.
Critical Limb Ischemia (CLI) Critical Limb Ischemia (CLI) is a severe obstruction of the arteries which markedly reduces blood flow to the extremities (hands, feet and legs) and has progressed to the point of severe pain and even skin ulcers or sores. The pain caused by CLI can wake up an individual at night.
Critical limb ischaemia is the most severe form of peripheral arterial disease and is often a result of arteriosclerosis or diabetes. It is characterised by resting ischaemic pain, nonhealing ulcer and gangrene. Untreated, 50% of patients with CLI will proceed to limb amputation and 25% will die within 1 year.