1 For example, the disorder sickle cell anaemia is caused by a mutation in the gene that instructs the building of a protein called haemoglobin. 2  This causes the red blood cells to become an abnormal, rigid, sickle shape. 3  However, in African populations, having this mutation also protects against malaria.
Optimistic time - generally the shortest time in which the activity can be completed. It is common practice to specify optimistic times to be three standard deviations from the mean so that there is approximately a 1% chance that the activity will be completed within the optimistic time.
Lead Time is the overlap between the first and second activity. For example, let us say that time duration for the first activity is 20 days, and for the second activity it is 15 days. As the first activity completes its first 15 days, you start working on the second activity. In this case weâd say that Lead Time is 5 days, or Finish to Start activity has 5 days Lead Time.