The company will, however, deduct the policy excess. Letâs say your car is worth Â£10,000 and is written-off in an accident. The insurance company might offer a settlement of Â£10,000, less the excess of Â£300, to give you Â£9,700.
It is now generally accepted that the demyelination seen in MS is caused by an abnormal immune process â that is, by activation of T cells (and perhaps B cells) against some component of central nervous system myelin (the fatty sheath that surrounds and insulates nerve fibers).
The activation of cytotoxic T cells is dependent on several simultaneous interactions between molecules expressed on the surface of the T cell and molecules on the surface of the antigen-presenting cell (APC).