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Freebase(0.00 / 0 votes)Rate this definition: Gynecomastia. Gynecomastia is the benign enlargement of breast tissue in males. It may occur transiently in newborns. Half or more of adolescent boys have some breast development during puberty.
Gynecomastia is thought to be caused by an altered ratio of estrogens to androgens mediated by an increase in estrogen production, a decrease in androgen production, or a combination of these two factors. Estrogen acts as a growth hormone to increase the size of male breast tissue.