How do you feel about Select Portfolio Servicing? Happy Happy 22%; Neutral Meh 0%; Sad Bad 78%
The classical site of muscarinic receptors is at the postganglionic parasympathetic neuroeffector junction in smooth muscle, heart, and exocrine glands. However, muscarinic receptors also exist on effectors cells, even in the absence of cholinergic innervation.Prototype agonists include muscarine and ACh.he classical site of muscarinic receptors is at the postganglionic parasympathetic neuroeffector junction in smooth muscle, heart, and exocrine glands. However, muscarinic receptors also exist on effectors cells, even in the absence of cholinergic innervation. Prototype agonists include muscarine and ACh.
Activation of the M 2 type activates an inhibitory G-protein, which inhibits adenylcyclase. Muscarinic receptor activation is linked to G-protein activation and second-messenger systems.The dominating receptors in the heart are the M 3 receptors mainly in the coronary circuit and the M 2 receptors elsewhere.