Taxonomic Notes: While subspecies taxonomy of Elephas maximus has varied among authors, the most recent treatment (Shoshani and Eisenberg 1982) recognizes three subspecies: E. m. indicus on the Asian mainland, E. m. maximus on Sri Lanka, and E. m. sumatranus on the Indonesian island of Sumatra.
How Does It Work? Avapro is part of a class of drugs called angiotensin II receptor blockers. As the name implies, the drug blocks angiotensin II receptors. This decreases the effectiveness of a chemical known as angiotensin II, which normally causes blood vessels to narrow (constrict).
AVAPROÂ® (irbesartan) is an angiotensin II receptor (AT1 subtype) antagonist. Irbesartan is a non-peptide compound, chemically described as a 2-butyl-3-[p-(o-1Htetrazol-5-ylphenyl)benzyl]-1,3-diazaspiro[4.4]non-1-en-4-one. Irbesartan is a white to off-white crystalline powder with a molecular weight of 428.5. It is a nonpolar compound with a partition coefficient (octanol/water) of 10.1 at pH of 7.4. Irbesartan is slightly soluble in alcohol and methylene chloride and practically insoluble in water.