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FDA Won't Let Me Sell You S.O.D. Supplements -Roger Mason. There are two major antioxidant enzymes in our bodies. S.O.D. or superoxide dismutase is one of the most important and powerful antioxidants in our body. The second is glutathione. This means they fight free radicals. You cannot take oral S.O.D. supplements, as they are broken down during digestion, and are, therefore, completely useless.