Leroy Satchel Paige was the longtime Negro League star who eventually received his due in the majors. He reportedly got his nickname working as a baggage porter in Mobile, Ala., where he became a satchel tree by carrying several bags at once. Satchel, the man, was literally ageless.
The diagnosis of AML requires the identification of 20% or more leukemic blasts in the bone marrow. Further analysis then must separate AML from acute lymphoblastic leukemia by showing evidence for commitment to the myeloid lineage.
DNA topoisomerase II agents may also produce gene rearrangements leading to AML, with a short latency period of 12 to 18 months following treatment. The latency between exposure to radiation therapy for other cancers and AML development is similar to that of alkylating agents.