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1 Squalene is a component of some adjuvants that are added to vaccines to enhance the immune response. 2  MF59, an adjuvant produced by Novartis and added to the FLUAD flu vaccine, is such an example. 3  Squalene by itself is not an adjuvant, but emulsions of squalene with surfactants do enhance the immune response.hat is squalene? 1  Squalene is a naturally occurring substance found in plants, animals, and humans. 2  Squalene is also found in a variety of foods, cosmetics, over-the-counter medications, and health supplements. 3  Squalene is commercially extracted from fish oil, and in particular shark liver oil.
Squalane is a hydrocarbon and triterpene derived by hydrogenation of squalene. Due to the complete saturation of squalane, it is not subject to auto-oxidation.This fact, coupled with lower costs associated with squalane make it desirable in cosmetic applications where it is used as an emollient and moisturizer.hile squalane can be found in small quantities in sebaceous secretions (sebum), it is squalene that is most commonly found in nature, most notably in the livers of sharks. Squalane has low acute toxicity and is not an irritant at the concentrations used in cosmetics.