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Explore further: Addition of a wheat gene increases the blight resistance of American chestnut trees. More information: Douglass F. Jacobs et al. Aboveground carbon biomass of plantation-grown American chestnut (Castanea dentata) in absence of blight, Forest Ecology and Management (2009).
The chestnut blight fungus can get by with one lesion. Also, the protectants will still let one or two through now and again, so again weren't efficacious. Finally, they only last two weeks or so and one would have to coat the entire aerial surface of the tree, so highly impractical.