HOW TO USE: Take this medication by mouth, usually 4 times a day (before meals and at bedtime) or as directed by your doctor. To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose.
Tacrolimus (also FK-506 or fujimycin, trade names Prograf, Advagraf, Protopic) is an immunosuppressive drug used mainly after allogeneic organ transplant to lower the risk of organ rejection.acrolimus was first approved by the Food and Drug Administration in 1994 for use in liver transplantation; this has been extended to include kidney, heart, small bowel, pancreas, lung, trachea, skin, cornea, bone marrow, and limb transplants.
It works by decreasing your body's immune system. Tacrolimus topical (for the skin) is used to treat severe atopic dermatitis (eczema). Tacrolimus may also be used for purposes not listed in this medication guide.ou should not use tacrolimus topical if you are allergic to it. To make sure you can safely use tacrolimus topical, tell your doctor if you have any of these other conditions: 1  skin cancer or a skin infection (including herpes or chickenpox); 2  any genetic skin disorder (such as Netherton's syndrome);