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However, the advice given by one of the manufacturers of metronidazole is that you should avoid drinking alcohol while taking it and for 48 hours after finishing the course. This makes sense because 48 hours is roughly the time it takes for metronidazole to be cleared from the body of an average adult. During this time, it may be sensible to also avoid cough and cold remedies and mouthwashes that contain alcohol.
Invasive amebiasis (e.g., colitis, liver abscess) should be treated with metronidazole for 10 days. Although metronidazole has some unpleasant side effects, such as headache, nausea, metallic taste, and a disulfiram-like reaction to alcohol, reaction is rarely severe.