Madelungâs disease is sometimes misdiagnosed as sialadenitis, an inflammation of the salivary glands. The inflammation may involve any of the glands that make up the salivary gland system (parotid, submandibular and sublingual glands).
However, use of ultrasonographic imaging should never preclude adequate resuscitation or definitive surgical therapy in a patient who is hemodynamically unstable and in whom ectopic pregnancy is strongly suspected. The goal of bedside ultrasonography is to diagnose an intrauterine pregnancy (IUP). Ectopic pregnancy can be reliably excluded in patients with a demonstrated IUP; heterotopic pregnancy remains very rare in patients who are not taking fertility agents.
Ubiquitin and the UPS. The ubiquitin proteasomal system (UPS) is a common method of regulation for many proteins in the cell. The modification is actually generated by E3 ubiquitin ligase, of which there are ~400-800 in the mammalian cell and the main source of specificity in the UPS (E2 ~40 and only 1 or 2 E1).biquitin is active as part of a complex of proteins. Other elements of the complex recognise the proteins to be degraded. These recognition or specificity proteins are responsible for targetting proteins for ubiquitination. They are called ubiquitin ligases.