The company will, however, deduct the policy excess. Letâs say your car is worth Â£10,000 and is written-off in an accident. The insurance company might offer a settlement of Â£10,000, less the excess of Â£300, to give you Â£9,700.
It is now generally accepted that the demyelination seen in MS is caused by an abnormal immune process â that is, by activation of T cells (and perhaps B cells) against some component of central nervous system myelin (the fatty sheath that surrounds and insulates nerve fibers).
Small peptide fragments, representing the entire cellular content, are transported to the cell surface as pMHCs, allowing T-cell surface expressed antigen specific TCRs to scan for foreign signals. T-cells interact with a large number of different cell types and recognise a diverse array of pathogens. This diversity has lead to distinct antigen recognition pathways which generate the appropriate T-cell response. T-cell activation can lead to a number of immune responses such as antibody production, activation of phagocytic cells and direct cell killing. In this way, the appropriate immune response for different types of diseases is implemented.