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RSI originated in the anesthesia literature to prevent aspiration in unprepped patients undergoing general anesthesia. From the first anecdotal reports of p-RSI in 1972, prehospital intubation has matured into widespread use. The often conflicting outcome data underscored the need to standardize the approach to p-RSI.
In May 1986 Mullis presented PCR at the Cold Spring Harbor Symposium, and published a modified version of his original 'idea' manuscript much later. The first non-Cetus report using PCR was submitted on September 5, 1986, indicating how quickly other laboratories began implementing the technique.