Side Effects. Side effects are rare; still symptoms like ear irritation, acute inflammation of the ear canal and pinna are reported. In some cases the pet might experience lack of appetite, vomiting, diarrhea, or hearing loss during the course of treatment, which might require immediate medical aid.
Furthermore, if the median age of a marathon participant is about 40, then the average maximum heart rate of a U.S. marathoner is about 180. Seventy percent of 180 is 126, while 80 percent is 144. Therefore, the heart rate of a mid-pack runner during a marathon is near the middle of the range -- between 126 and 144, or 135 beats per minute.
Marathon runners often peak in their late 30s despite their hearts beating less times per minute than a 10-year-old or a 20-year-old. If you want to determine your maximum heart rate, or the maximum number of times your heart can beat per minute, subtract your age from 220. Say, for example, you are 40 years old. Subtracting 40 from 220 leaves 180, the maximum number of heart beats per minute for a 40-year-old.