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The most visibly noticeable symptoms occur if mucosal melanoma affects the female genitals. These symptoms may include changes in an existing mole or formation of a new skin growth (generally on the vulva), and may also include pain, itching, bleeding, or other discharge.When mucosal melanoma occurs in the mouth, it may cause pain similar to a canker sore.hese symptoms may include changes in an existing mole or formation of a new skin growth (generally on the vulva), and may also include pain, itching, bleeding, or other discharge. When mucosal melanoma occurs in the mouth, it may cause pain similar to a canker sore.
People should tell their doctor if they notice any changes on the skin. The only way to diagnose melanoma is to remove tissue and check it for cancer cells. Thinking of ABCDE can help you remember what to look for: 1  Asymmetry: The shape of one half does not match the other half.2  Border that is irregular: The edges are often ragged, notched, or blurred in outline. 3  The pigment may spread into the surrounding skin.elow are photos of melanoma that formed on the skin. Melanoma can also start in the eye, the intestines, or other areas of the body with pigmented tissues. Often the first sign of melanoma is a change in the shape, color, size, or feel of an existing mole. However, melanoma may also appear as a new mole.