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The classical site of muscarinic receptors is at the postganglionic parasympathetic neuroeffector junction in smooth muscle, heart, and exocrine glands. However, muscarinic receptors also exist on effectors cells, even in the absence of cholinergic innervation.Prototype agonists include muscarine and ACh.he classical site of muscarinic receptors is at the postganglionic parasympathetic neuroeffector junction in smooth muscle, heart, and exocrine glands. However, muscarinic receptors also exist on effectors cells, even in the absence of cholinergic innervation. Prototype agonists include muscarine and ACh.
Molecular Physiology of Muscarinic Receptors (Optional Reading). Muscarinic acetylcholine receptors --- like nicotinic receptors -- are proteins that extend through the cell membrane from the outside to the inside. However, they do not contain channels to allow ions inside the cell.uscarinic, G-Protein Mediated Receptors. The key response differences between muscarinic and nicotinic receptors is that the response of muscarinic receptors: (Hoffman and Taylor 2001). 1  Is slower. 2  May be excitatory or inhibitory.