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A full set of sister chromatids is created during the S subphase of interphase, when all the DNA in a cell is replicated. Identical chromosome pairs are separated into two different cells during mitosis, or cellular division.
The two identical chromosomes that result from DNA replication are referred to as sister chromatids. Sister chromatids are held together by proteins at a region of the chromosome called the centromere.Chromosomes undergo additional compaction at the beginning of mitosis. When fully condensed, replicated chromosomes appear as thick X-shaped structures that are readily observed under the microscope (see figure below).hromosomes are packaged by histone proteins into a condensed structure called chromatin. The first level of packaging is represented as the âbeads-on-a-stringâ structure. The condensed chromatin is folded and tightly coiled, like a coiled telephone cord, allowing the cellâs DNA to be packed into the nucleus.