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FOLFOX is a chemotherapy regimen for treatment of colorectal cancer, made up of the drugs.
Folate is a cofactor in one-carbon metabolism, during which it promotes the re-methylation of homocysteine-a cytotoxic and pro-oxidant sulfur-containing amino acid that can induce DNA strand breakage, increase the risk of heart disease, and cause various forms of vascular disease, oxidative stress, and apoptosis.