The company will, however, deduct the policy excess. Letâs say your car is worth Â£10,000 and is written-off in an accident. The insurance company might offer a settlement of Â£10,000, less the excess of Â£300, to give you Â£9,700.
It is now generally accepted that the demyelination seen in MS is caused by an abnormal immune process â that is, by activation of T cells (and perhaps B cells) against some component of central nervous system myelin (the fatty sheath that surrounds and insulates nerve fibers).
CTLA4 has a role in T-cell activation and shares significant sequence identity with CD28; the 2 mouse proteins are 76% alike. Whereas CD28 is found on the membrane of resting T cells, CTLA4 is detectable only on cells activated after antigen presentation. Both molecules bind to the same ligands. Waterhouse et al.