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A larger peak in activity at around 6 hours is usually associated with a shorter action time, and vice versa. Anyone who does not take their long-acting insulin at about the same time each day can also experience gaps and stacking of insulin with a single injection a day. Smaller doses are also often associated with greater insulin activity at 6 hours with less at 18 hours and beyond.
The peak and duration of insulin is affected by many things including individual response, time of day, exercise, stress, sickness, and content of a meal (high-fat meals can lead to hypoglycemia). You may be more responsive to insulin at certain times of the day, and less responsive at others. It is important to keep a log of when your blood glucose readings, food, activity level, and insulin dose and time in order for your doctor to help you determine the best daily care plan for your needs.