The company will, however, deduct the policy excess. Letâs say your car is worth Â£10,000 and is written-off in an accident. The insurance company might offer a settlement of Â£10,000, less the excess of Â£300, to give you Â£9,700.
It is now generally accepted that the demyelination seen in MS is caused by an abnormal immune process â that is, by activation of T cells (and perhaps B cells) against some component of central nervous system myelin (the fatty sheath that surrounds and insulates nerve fibers).
When CAR T-cells are infused, myeloid and various lymphoid cell populations are activated, which leads to the massive release of cytokines responsible for CRS. Signs and Symptoms of CRS Cardiovascular, pulmonary, renal, hepatic, gastrointestinal, hematologic, musculoskeletal, neurologic and immune systems may all potentially be affected by CAR T cell-associated CRS.