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Biochemistry of Dog Coat Color. The color of a dogâs coat is determined by relative levels of two pigments: eumelanin, which can be either brown or black, and pheomelanin, which is yellow to orange or red. Both pigments are generated by metabolism of tyrosine. A schematic diagram of the pathway is below. Schematic of the melanin synthesis pathways.
Dogs that are black, brown or blue do not show their mask against their similar body color. The mask is inherited as a dominant trait. Possible Genotypes: 1  EmEm â the dog is masked and has 2 copies of the dominant allele. 2  EmEx â the dog is masked & has 1 dominant allele & 1 recessive allele.