The company will, however, deduct the policy excess. Letâs say your car is worth Â£10,000 and is written-off in an accident. The insurance company might offer a settlement of Â£10,000, less the excess of Â£300, to give you Â£9,700.
It is now generally accepted that the demyelination seen in MS is caused by an abnormal immune process â that is, by activation of T cells (and perhaps B cells) against some component of central nervous system myelin (the fatty sheath that surrounds and insulates nerve fibers).
T cell responses targeting myelin antigens are possibly involved in the pathogenesis of demyelinating diseases, such as multiple sclerosis (MS).Little is known about human T cell responses to 2â²,3â²-cyclic nucleotide 3â²-phosphodiesterase (CNPase), the third most abundant myelin protein.We examined the primary peripheral T cell response to CNPase and characterized CNPase-specific CD4+ long-term T cell lines (TCL) from MS patients and healthy donors.The strongest primary responses were found in two MS patients with very active disease and were directed against CNP(343â373).NPase, constituting about 4% of human total myelin protein, is the third most abundant myelin protein after PLP and MBP, and is predominantly found in central nervous system (CNS) myelin in the oligodendroglial membrane, in paranodal segments and in periaxonal regions Sprinkle, 1989 and Tsukada and Kurihara, 1992.