An archive is an accumulation of historical records or the physical place they are located.[1] Archives contain primary source documents that have accumulated over the course of an individual or organization's lifetime, and are kept to show the function of that person or organization.
Pfeiffer syndrome is a complex genetic disorder that affects your childâs head, face, hands and feet. Clinical features vary for different children and range from mild to severe. Craniosynostosis: Premature (early) closure of growth plates of the skull that changes the shape of the head and can put increased pressure on the brain.
A number sign (#) is used with this entry because Pfeiffer syndrome can be caused by heterozygous mutations in the FGFR1 gene (136350) on chromosome 8 or in the FGFR2 gene (176943) on chromosome 10.Some families do not map to either of these loci by linkage studies, suggesting additional genetic heterogeneity. number sign (#) is used with this entry because Pfeiffer syndrome can be caused by heterozygous mutations in the FGFR1 gene (136350) on chromosome 8 or in the FGFR2 gene (176943) on chromosome 10.