The most common causes of CKD do not cause any pain. And, much of the pain that is near the kidneys is not caused by a kidney problem. But some people who have CKD do have pain. Some people with kidney problems may have pain in the upper back (where the kidneys are) or on the same side as the affected kidney.he most common causes of CKD do not cause any pain. And, much of the pain that is near the kidneys is not caused by a kidney problem. But some people who have CKD do have pain. Some people with kidney problems may have pain in the upper back (where the kidneys are) or on the same side as the affected kidney.
Diuretics are used to treat disorders such as hypertension and several types of edema that are caused by conditions such as heart failure and cirrhosis of the liver. However, use of diuretics can lead to complications, including dehydration and electrolyte imbalances. The action of carbonic anhydrase inhibitors reduces the rate of hydrogen ion secretion and there reabsorption of bicarbonate ions. The bicarbonate ions increase tubular osmotic pressure, causing osmotic diuresis. With long-term use, the diuretic effects of carbonic anhydrase inhibitors tends to be lost.
The thiazides are the most commonly used oral diuretics and are widely used in the therapy of hypertension and congestive heart failure, as well as the treatment of edema due to local, renal and hepatic causes.