Gothic fiction, which is largely known by the subgenre of Gothic horror, is a genre or mode of literature that combines fiction, horror, death and Romanticism.ts origin is attributed to English author Horace Walpole, with his 1764 novel The Castle of Otranto, subtitled (in its second edition) A Gothic Story.. The effect of Gothic fiction feeds on a pleasing sort of terror, an extension of Romantic literary pleasures that were relatively new at the time of Walpole's novel.
The pituitary gland, a small gland at the base of the brain, makes and secretes a hormone known as adrenocorticotropic hormone, or ACTH. Secretion of ACTH signals the adrenal glands to increase cortisol production and secretion.The pituitary, in turn, receives signals from the hypothalamus of the brain in the form of the hormone CRH, or corticotrophin-releasing hormone, which signals the pituitary to release ACTH.he marker used to measure stress is the adrenal steroid hormone, cortisol. Stress, whether physical or emotional in origin, provokes a response by the adrenal glands. Many hormonal imbalances are the direct result of adrenal insufficiency. The adrenal glands produce two primary hormones, DHEA and cortisol.
Synthesis takes place in the zona fasciculata of the adrenal cortex. (The name cortisol is derived from cortex.) While the adrenal cortex also produces aldosterone (in the zona glomerulosa) and some sex hormones (in the zona reticularis), cortisol is its main secretion in humans and several other species.