Meaning to close by folding or bringing together is from mid-14c. Sense of to set (someone) free (from) (c.1500) is obsolete except in dialectal phrases such as to get shut of. Colloquial shut-eye for sleep is from 1899. To shut (one's) mouth desist from speaking is recorded from 1340.
Medical Device Regulation Act. Medical Device Amendments of 1976. An Act to amend the Federal Food, Drug, and Cosmetic Act to provide for the safety and effectiveness of medical devices intended for human use, and for other purposes. Enacted by.
Mandatory Medical Device Reporting: The Medical Device Reporting (MDR) regulation (21 CFR 803) contains mandatory requirements for manufacturers, importers, and device user facilities to report certain device-related adverse events and product problems to the FDA. The regulation specified that reports be filed on FDA Medwatch Form 3500A or an electronic equivalent.