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A larger peak in activity at around 6 hours is usually associated with a shorter action time, and vice versa. Anyone who does not take their long-acting insulin at about the same time each day can also experience gaps and stacking of insulin with a single injection a day. Smaller doses are also often associated with greater insulin activity at 6 hours with less at 18 hours and beyond.
Rapid-acting insulin works more quickly than other types of insulin. Humalog and Novolog are in the rapid-acting class of insulin. The American Diabetes Association estimates that both medications start working after 15 minutes. Humalog and Novolog last 2 to 4 hours and reach their peak after 1 hour. The exact time frame of the onset, peak, and duration may vary slightly for you. Thatâs why itâs important to check your blood sugar levels before and after taking Humalog or Novolog.