1 For example, the disorder sickle cell anaemia is caused by a mutation in the gene that instructs the building of a protein called haemoglobin. 2  This causes the red blood cells to become an abnormal, rigid, sickle shape. 3  However, in African populations, having this mutation also protects against malaria.
Optimistic time - generally the shortest time in which the activity can be completed. It is common practice to specify optimistic times to be three standard deviations from the mean so that there is approximately a 1% chance that the activity will be completed within the optimistic time.
1 Any%, or fastest completion, refers to completing the game as quickly as possible, and often involves sequence breaking. Any% is the most common category, as it has the least amount of restrictions on what you can and can't do.  100%, or full completion, requires the player to complete the game to its fullest.