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The classical site of muscarinic receptors is at the postganglionic parasympathetic neuroeffector junction in smooth muscle, heart, and exocrine glands. However, muscarinic receptors also exist on effectors cells, even in the absence of cholinergic innervation.Prototype agonists include muscarine and ACh.he classical site of muscarinic receptors is at the postganglionic parasympathetic neuroeffector junction in smooth muscle, heart, and exocrine glands. However, muscarinic receptors also exist on effectors cells, even in the absence of cholinergic innervation. Prototype agonists include muscarine and ACh.
Muscarinic receptors responding to the natural ligand acetylcholine have a widespread tissue distribution and are involved in the control of numerous central and peripheral physiological responses, as well as being a major drug target in human disease.uscarinic receptor physiological role. The role of muscarinic receptors in the contraction of smooth muscle, particularly of airway, ileum, iris and bladder, are considered a classical muscarinic response mediated primarily by M 3 -muscarinic receptors expressed on the smooth muscle cells [ 8, 11 ].