TGF-b is synthesized in a latent form linked to a glycoprotein (latent TGF-b binding protein, LTBP), which serves as an anchor in the ECM. Proteolytic cleavage of LTBP is a prerequisite for the release and generation of bioactive (mature) TGF-b.
Akata is a slang sometimes used to describe Black/African Americans. It is also used to describe Africans who have lived in America for a considerable length of time. ' 1 Akata' in Yoruba language means ' fox' .
The chronic form is more difficult to recognise, often co-existing with TD with a mixture of choreoathetoid and dystonic features. Akathisia is a particularly distressing aspect of the extrapyramidal syndrome, often starting within a few days of the initiation of treatment. Patients experience a sense of inner restlessness, mental unease, unrest or dysphonia.