HOW TO USE: Take this medication by mouth, usually 4 times a day (before meals and at bedtime) or as directed by your doctor. To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose.
Tacrolimus (also FK-506 or fujimycin, trade names Prograf, Advagraf, Protopic) is an immunosuppressive drug used mainly after allogeneic organ transplant to lower the risk of organ rejection.acrolimus was first approved by the Food and Drug Administration in 1994 for use in liver transplantation; this has been extended to include kidney, heart, small bowel, pancreas, lung, trachea, skin, cornea, bone marrow, and limb transplants.
Prograf Â® (tacrolimus) is sometimes used in the treatment of this condition. Because it can cause potentially serious side effects, Prograf is normally reserved for people who have failed other treatments, such as corticosteroids.ore Information About Nephrotic Syndrome. 1  Low levels of protein in the blood. 2  Swelling (edema), especially of the face, hands, feet, and ankles. 3  High cholesterol levels. 4  Foamy urine (caused by the excess protein).