The company will, however, deduct the policy excess. Letâs say your car is worth Â£10,000 and is written-off in an accident. The insurance company might offer a settlement of Â£10,000, less the excess of Â£300, to give you Â£9,700.
It is now generally accepted that the demyelination seen in MS is caused by an abnormal immune process â that is, by activation of T cells (and perhaps B cells) against some component of central nervous system myelin (the fatty sheath that surrounds and insulates nerve fibers).
Crohn's disease is due to stimulation of Th1 and ulcerative colitis is due to stimulation of Th2[44]. Mucosal T cells from indeterminate colitis exhibit an intrinsic hyperreactivity to IL-2 and grew similarly to those of CD mucosa. This may represent a primary pathogenic abnormality in this condition[45].