There are many causes of nystagmus. Nystagmus may be present at birth. It may be a result of the lack of development of normal binocular fixation early on in life. This can occur if there is a cataract at birth or a problem is some other part of the visual system.
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After spending more than a week in Portugal, and paying his respects to Eleanor of Viseu, Columbus again set sail for Spain. Ferdinand Magellan was a young boy and a ward of Eleanor's court; it is likely he saw Columbus during this visit.