The half-life of methadone ranges between 8 to 59 hours, which is bifurcated into 15 to 60 hours in case of (R-S) Methadone and 10 to 40 hours for (R) Methadone. Its analgesic action can be manifested between 4 to 8 hours, while the peak levels of the drug in the blood plasma are reached after 4 hours.
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