Side Effects. Side effects are rare; still symptoms like ear irritation, acute inflammation of the ear canal and pinna are reported. In some cases the pet might experience lack of appetite, vomiting, diarrhea, or hearing loss during the course of treatment, which might require immediate medical aid.
Furthermore, if the median age of a marathon participant is about 40, then the average maximum heart rate of a U.S. marathoner is about 180. Seventy percent of 180 is 126, while 80 percent is 144. Therefore, the heart rate of a mid-pack runner during a marathon is near the middle of the range -- between 126 and 144, or 135 beats per minute.
With the average heart rate of 72 beats per minute the heart will pump about 5 litres per ventricle, or about 10 litres total per minute. This is called the cardiac output. In a trained athlete the total cardiac output is about 20 litres. If we multiply the normal, non-athlete output by the average age of 70 years, we see that the cardiac output of the average human heart over a life time would be about 1 million litres, or about 250,000 gallons(US)!