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FOLFOX is a chemotherapy regimen for treatment of colorectal cancer, made up of the drugs.
The response to the fluoropyrimidine 5-fluorouracil (5-FU) as a first line monotherapy is low (10-15% for advanced colorectal cancer), so it is often given as part of a regimen with other cytotoxic drugs such as oxaliplatin (known as FOLFOX) and irinotecan (FOLFIRI).