Per general etiquette, the mother of the bride buys her wedding day outfit first, then notifies the mother of the groom about the color, length and overall formality of her choice. But if the groom's mom doesn't get word by the four-month mark, she should touch base with the bride-to-be about what to do.
Genetics. The two main types of hemophilia are caused by gene mutations that affect the levels of clotting factors in the blood. Mutation of the FVIII gene leads to hemophilia A, also called classic hemophilia, while a mutations in the FIX gene leads to hemophilia B, also called Christmas disease.
Hemophilia arises from an inherited gene mutation that impedes the ability to produce normal levels of a blood clotting factor. This leaves patients vulnerable to spontaneous bleeding or excessive bleeding from injuries. The disorder has two major forms: hemophilia A, which affects about 80 percent of all patients, and hemophilia B. Hemophilia B occurs in about 1 in 30,000 boys and men, George said. Because the recessive gene disorder is linked to the X chromosome, women can be carriers but are unaffected by the condition.