In humans (n = 10) infused with 1.0â1.3 mmol sodium dl-lactate/(kg Â· h), â¼90% of d-lactate was metabolized, and 10% excreted in the urine (12). At higher infusion rates of 3.0â4.6 mmol/(kg Â· h), metabolism decreased to â¼75% of overall clearance (12).
Deaths from alcohol poisoning as a contributing cause peaked for those between ages 35 and 44 (average age at death was 39.9 years). When the age-specific rate was calculated using deaths with any mention of alcohol poisoning, the rate was highest at ages 35 to 44 (1.33 deaths per 100,000 population).
This accounts for 2.5 million deaths, with over 300,000 between the ages of 15 and 29. Alcohol is a factor in up to 60 different diseases and injuries which include cirrhosis, poisonings, violence, cancer and heart disease. It is reportedly the worldâs third-largest risk factor for disease burden.