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High BUN indicates increased protein breakdown, which is associated with decreased immune function. A study shows that patients with elevated BUN (> 20 mg/dl) have an increased risk of infection (R). High BUN is associated with increased mortality in critically ill patients (R, R, R, R).
BUN (blood urea nitrogen) is influenced by the liver, kidneys, and by dehydration. Blood urea nitrogen is a waste product produced by the liver from proteins from the diet, and is eliminated from the body by the kidneys. A low BUN can be seen with liver disease and an increased BUN is seen in pets with kidney disease. The kidneys must be damaged to the point that 75% of the kidneys are nonfunctional before BUN will increase.