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High BUN indicates increased protein breakdown, which is associated with decreased immune function. A study shows that patients with elevated BUN (> 20 mg/dl) have an increased risk of infection (R). High BUN is associated with increased mortality in critically ill patients (R, R, R, R).
Both high serum creatinine (Scr) and high blood urea nitrogen (BUN) can reflect the damage degree of glomerular filtration rate. If BUN/creatinine ratio increases, it may indicate some disorders. Creatinine and BUN levels. In addition to kidney disease, BUN level can also be affected by some other factors such as high-protein diet, hemorrhage of digestive tract, dehydration or high metabolism.