The origin of replication (also called the replication origin) is a particular sequence in a genome at which replication is initiated.
It is the interaction of two or more substances, resulting in chemical changes in them. Chemical reactions take place when some kind of energy is supplied to them. The supplied energy may be in the form of heat, light or mechanical shaking for proper contact between the reactant molecules or electricity.
Heating substances, therefore, usually causes the rate of a chemical reaction to increase. Heating a substance makes its particles move more rapidly and collide more frequently. When they collide, bonds between the particles are broken and new ones are more easily formed with the particles of other substances.