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This medication also is frequently used to administer general anesthesia for surgery. Propofol requires different patient monitoring during the procedure and, depending upon circumstances, may require anesthesia personnel, and so involve additional patient cost. Most of the time, the medicine is given through a vein.
Propofol is also used for procedural sedation, for example during endoscopic procedures. Its use in these settings results in a faster recovery compared to midazolam. Because of its fast induction and recovery time, propofol is also widely used for sedation of infants and children undergoing MRI.he half-life of elimination of propofol has been estimated to be between 2 and 24 hours. However, its duration of clinical effect is much shorter, because propofol is rapidly distributed into peripheral tissues. When used for IV sedation, a single dose of propofol typically wears off within minutes.