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High BUN indicates increased protein breakdown, which is associated with decreased immune function. A study shows that patients with elevated BUN (> 20 mg/dl) have an increased risk of infection (R). High BUN is associated with increased mortality in critically ill patients (R, R, R, R).
When the BUN level is considered dangerous? If your creatinine level is higher than 20 mg/dL, your kidneys may not be working at full strength. However, to judge whether certain BUN level is dangerous depends on many factors. Compared with BUN, creatinine is a better indicator of kidney function. If your creatinine level remains stable but BUN level increases, this could be due to dehydration, a large amount of protein intake or intestinal tract bleeding.