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1 Ghrelin is secreted by endocrine cells in the stomach, especially when one is hungry and. 2  acts on the hypothalamus to stimulate feeding. 3  This action counteracts the inhibition of feeding by leptin and PYY3-36. Ghrelin is secreted by endocrine cells in the stomach, especially when one is hungry and. 2  acts on the hypothalamus to stimulate feeding. 3  This action counteracts the inhibition of feeding by leptin and PYY3-36.
Ghrelin is a hormone produced by specialized cells that line the stomach and the pancreas. In the stomach, cells that secrete ghrelin include the P/D1 cells in the fundus or upper part of the stomach and in the pancreas, ghrelin secreting cells are called epsilon cells.