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Two atria and one ventricle make up the three-chambered heart of a snake. The right and left atria receive blood from the lungs and body, respectively, and pass it to the ventricle to be circulated again. Encased in a sac, called the pericardium, the heart is located at the branching of the bronchi.
The heart of most snakes is located at a point one-third to one-fourth of its length caudal to the head. In some aquatic species, the heart is located in a more cranial position. The chelonian heart is located on the ventral midline where the humeral, pectoral, and abdominal scutes of the plastron intersect. In most species of lizards, the heart is encased in the pectoral girdle.