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Lack of evidence: There is little evidence to suggest that low dose Seroquel is an effective treatment for insomnia. Despite the drugâs perception of being an effective treatment for insomnia, there is minimal evidence in support of these claims.
1 Non-benzodiazepine hypnotics, such as zolpidem (Ambien), zaleplon (Sonata), and eszopiclone (Lunesta); these drugs are used to treat short-term insomnia.  Melatonin receptor stimulator, ramelteon (Rozerem), was approved in 2005 and -- to date -- is in a class by itself. It is used to treat insomnia.