Duloxetine is also sometimes used to treat stress urinary incontinence (leakage of urine during physical activity such as coughing, sneezing, laughing, and exercise) in women. Talk to your doctor about using this medication to treat your condition.
Water's density maximum is a product of the same phenomenon. Close to the freezing point, the water molecules start to arrange locally into ice-like structures. This creates some openness in the liquid water, which tends to decrease its density.
Air pressure certainly affects the freezing temperature. The higher the pressure, the lower the freezing temperature. Since it will take water longer to reach the lower temperature, I'd expect that it would freeze more slowly. There are two ways that the higher pressure lowers the freezing temperature. One is direct.