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Lack of evidence: There is little evidence to suggest that low dose Seroquel is an effective treatment for insomnia. Despite the drugâs perception of being an effective treatment for insomnia, there is minimal evidence in support of these claims.
With quetiapine (Seroquel), 50 mg should be enough for insomnia (this is the dose I recommend). It has marked sedative effects, even at 25 mg for people who are sensitive to the drug or have never tried it before. It is a very strong sedative. I wouldn't go beyond 50 mg.