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1 Ghrelin is secreted by endocrine cells in the stomach, especially when one is hungry and. 2  acts on the hypothalamus to stimulate feeding. 3  This action counteracts the inhibition of feeding by leptin and PYY3-36. Ghrelin is secreted by endocrine cells in the stomach, especially when one is hungry and. 2  acts on the hypothalamus to stimulate feeding. 3  This action counteracts the inhibition of feeding by leptin and PYY3-36.
Ghrelin is produced and secreted by specialized cells in the stomach (and to some extent by intestine and placenta) and the upper part of the small intestine.t is now established that ghrelin is a peripheral signal from the stomach that is secreted upon hunger. Ghrelin travels in the blood to the brain where it activates neurons in the hypothalamus and stimulates eating.