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1 Ghrelin is secreted by endocrine cells in the stomach, especially when one is hungry and. 2  acts on the hypothalamus to stimulate feeding. 3  This action counteracts the inhibition of feeding by leptin and PYY3-36. Ghrelin is secreted by endocrine cells in the stomach, especially when one is hungry and. 2  acts on the hypothalamus to stimulate feeding. 3  This action counteracts the inhibition of feeding by leptin and PYY3-36.
For example, many hormones play a role. When your stomach is empty, the hormone, ghrelin, which is produced mainly in the stomach, signals your brain that you need to take in food. Your body produces more ghrelin during fasting (such as between meals) in order to stimulate hunger, and it produces less after food is consumed.