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endothelial cell. (histology). A type of squamous epithelial cell composing the endothelium. 1  Facebook. 2  Twitter.
Medical Definition of ENDOTHELIUM. : an epithelium of mesoblastic origin composed of a single layer of thin flattened cells that lines internal body cavities (as the serous cavities or the interior of the heart).. : an epithelium of mesodermal origin composed of a single layer of thin flattened cells that lines internal body cavities and the lumens of vessels. 2. : the inner layer of the seed coat of some plants.