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High BUN indicates increased protein breakdown, which is associated with decreased immune function. A study shows that patients with elevated BUN (> 20 mg/dl) have an increased risk of infection (R). High BUN is associated with increased mortality in critically ill patients (R, R, R, R).
When the kidneys arenât functioning well, your serum creatinine levels rise, the NKF says. Elevated BUN levels also occur when kidney function slows down. BUN can also rise when you eat more animal protein and fall if you consume less, the NKF says.