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Freebase(0.00 / 0 votes)Rate this definition: OSIsoft. OSIsoft, LLC is a worldwide manufacturer of Application software for real-time data infrastructure solutions, called the PI System. Founded in 1980, OSIsoft, LLC is privately held and headquartered in San Leandro, CA, with operations worldwide.
The main concept of OSI is that the process of communication between two endpoints in a telecommunication network can be divided into seven distinct groups of related functions, or layers. Each communicating user or program is at a computer that can provide those seven layers of function.