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High BUN indicates increased protein breakdown, which is associated with decreased immune function. A study shows that patients with elevated BUN (> 20 mg/dl) have an increased risk of infection (R). High BUN is associated with increased mortality in critically ill patients (R, R, R, R).
Yes, the transient increases in creatinine can be caused by dehydration. Dehydration generally causes BUN levels to rise more than creatinine levels. This causes a high BUN-to-creatinine ration. While kidney disease or blockage of the flow of urine from your kidney causes both BUN and creatinine levels to rise. So a BUN-to-creatinine ratio can help doctor check for problems, such as dehydration. Patients with one kidney seem to be particularly susceptible to the effect of dehydration on creatinine.