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High BUN indicates increased protein breakdown, which is associated with decreased immune function. A study shows that patients with elevated BUN (> 20 mg/dl) have an increased risk of infection (R). High BUN is associated with increased mortality in critically ill patients (R, R, R, R).
Factors that Decrease BUN. 1  Low-protein diet, malnutrition or starvation (R). 2  Impaired liver activity due to liver disease (R). 3  Genetic deficiency of urea cycle enzymes (R). 4  Higher IGF-1 and growth hormone. 5  Anabolic steroids, which decreases protein breakdown. 6  Overhydration, or drinking a lot of water. 7  Pregnancy (due to increased plasma volume) (R).