Webster Dictionary(5.00 / 1 vote)Rate this definition: 1  Lode(noun) a water course or way; a reach of water. 2  Lode(noun) a metallic vein; any regular vein or course, whether metallic or not.
An anticholinergic medication may be recommended to reduce symptoms of bothersome tremor in people with Parkinson disease under age 70 who do not have significant akinesia or difficulty walking. Anticholinergics may be given alone, or with levodopa or dopamine agonists in people with more advanced disease who have a persistent tremor.
Primidone is not the only anticonvulsant used for essential tremor; the others include topiramate (Topamax) and gabapentin (Neurontin). Other pharmacological agents include alprazolam (Xanax), clonazepam (Klonopin), atenolol, sotalol, nadolol, clozapine, nimodipine, and botilinum toxin A.rimidone converts to phenobarbital and PEMA; it is still unknown which exact cytochrome P450 enzymes are responsible. The phenobarbital, in turn, is metabolized to p-hydroxyphenobarbital.