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1 Ghrelin is secreted by endocrine cells in the stomach, especially when one is hungry and. 2  acts on the hypothalamus to stimulate feeding. 3  This action counteracts the inhibition of feeding by leptin and PYY3-36. Ghrelin is secreted by endocrine cells in the stomach, especially when one is hungry and. 2  acts on the hypothalamus to stimulate feeding. 3  This action counteracts the inhibition of feeding by leptin and PYY3-36.
Medical Definition of GHRELIN. : a 28-amino-acid peptide hormone that is secreted primarily by stomach cells with lesser amounts secreted by other cells (as of the hypothalamus), that is a growth hormone secretagogue, and that has been implicated in the stimulation of fat storage and food intake.weet. : a 28-amino-acid peptide hormone that is secreted primarily by stomach cells with lesser amounts secreted by other cells (as of the hypothalamus), that is a growth hormone secretagogue, and that has been implicated in the stimulation of fat storage and food intake.