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Adverse Effects And Risks Of Long-Term Opioid Use. Most medications have adverse effects and opioids are no different. Adverse effects of opioids may include fatigue, constipation, sedation, nausea, vomiting, confusion, dry mouth, constricted pupils (miosis), and itching (pruritis).
WARNINGS AND PRECAUTIONS. 1  Respiratory depression is the chief hazard from all opioid agonist preparations. In some patients, usual therapeutic doses of opioids may cause respiratory depression. 2  There have been post-marketing reports of hypersensitivity and anaphylaxis associated with use of acetaminophen.