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1 Insulin sensitivity is increased, so your cells are better able to use any available insulin to take up glucose during and after activity. 2  When your muscles contract during activity, it stimulates another mechanism that is completely separate of insulin.
If insulin sensitivity is decreased, blood sugar levels can rise. This is a sign that someone either has or is at increased risk of having diabetes. Prior to the test the men were given either caffeine tablets equal to 2 to 3 cups of coffee or a placebo. Results showed that caffeine reduced the men's ability to process blood sugar. It also interfered with insulin, the body's hormone that handles blood sugar.