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Wiktionary (0.00 / 0 votes) Rate this definition: disease (Noun). An abnormal condition of the body or mind that causes discomfort or dysfunction; distinct from injury insofar as the latter is usually instantaneously acquired. The tomato plants had some kind of disease that left their leaves splotchy and fruit withered. disease (Noun). Any abnormal or harmful condition, as of society, people's attitudes, way of living etc. disease (Verb). To cause unease; to annoy, irritate. disease (Verb). To infect with a disease.
Definition of disease. 1  1 obsolete : trouble. 2  2 : a condition of the living animal or plant body or of one of its parts that impairs normal functioning and is typically manifested by distinguishing signs and symptoms : sickness, malady infectious diseases a rare genetic disease heart disease.