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High BUN indicates increased protein breakdown, which is associated with decreased immune function. A study shows that patients with elevated BUN (> 20 mg/dl) have an increased risk of infection (R). High BUN is associated with increased mortality in critically ill patients (R, R, R, R).
1 Dehydration generally causes BUN levels to rise more than creatinine levels. 2  This causes a high BUN-to-creatinine ratio. 3  Kidney disease or blockage of the flow of urine from your kidney causes both BUN and creatinine levels to rise.he blood creatinine level shows how well your kidneys are working. A high creatinine level may mean your kidneys are not working properly. The amount of creatinine in the blood depends partly on the amount of muscle tissue you have. Men generally have higher creatinine levels than women.