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endothelial cell. (histology). A type of squamous epithelial cell composing the endothelium. 1  Facebook. 2  Twitter.
The endothelial cell is thought to arise from the splanchnopleuric mesoderm. Endothelial cells form the inner lining of a blood vessel and provides an anticoagulant barrier between the vessel wall and blood.In addition to its role as a selective permeability barrier, the endothelial cell is a unique multifunctional cell with critical basal and inducible metabolic and synthetic functions.ell facts: (1) Endothelium consists of approximately (1-6) x 10(13) endothelial cells forming an almost 1 kg organ. (2) They uniquely contain Weibel-Palade bodies, 0.1 microm wide, 3 microm long membrane-bound structures that represent the storage organelle for von Willebrand factor (vWF).