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High BUN indicates increased protein breakdown, which is associated with decreased immune function. A study shows that patients with elevated BUN (> 20 mg/dl) have an increased risk of infection (R). High BUN is associated with increased mortality in critically ill patients (R, R, R, R).
Itchy skin is another annoying symptom that occurs easily when BUN is elevated. As we have mentioned, urea nitrogen is the end product of protein. They can stimulate skin and sebaceous gland, and thus cause atrophy of sweat gland, which can cause dry skin and itchy skin.. Tiredness. Kidney disease patients with elevated BUN may find they become tired easily and this is usually caused by renal anemia which is diagnosed when red blood cell account is lower than the normal range due to kidney disease. 4. Foamy urine. Foamy urine is the clinical manifestation of proteinuria.