The origin of replication (also called the replication origin) is a particular sequence in a genome at which replication is initiated.
It is the interaction of two or more substances, resulting in chemical changes in them. Chemical reactions take place when some kind of energy is supplied to them. The supplied energy may be in the form of heat, light or mechanical shaking for proper contact between the reactant molecules or electricity.
You answer your own question. There is a fall in temperature because the reaction is endothermic. The reaction needs energy, so unless you can supply some heat, the temperature will fall. Eventually, some heat from the surroundings will transfer and equilibrate the temperature. Temperature of the system is a measure of the global energy. Most reactions are exothermic so now the temperature rises and then transfers to the surroundings. A very famous example is a burning fire.