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Freebase(0.00 / 0 votes)Rate this definition: OSIsoft. OSIsoft, LLC is a worldwide manufacturer of Application software for real-time data infrastructure solutions, called the PI System. Founded in 1980, OSIsoft, LLC is privately held and headquartered in San Leandro, CA, with operations worldwide.
(1) OSI (pronounced as separate letters) is short for Open System Interconnection. OSI is an ISO standard for worldwide communications that defines a networking framework for implementing protocols in seven layers.