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Thick blood is caused by a variety of conditions, such as heavy proteins in the blood, too much blood in circulation or a blood clot system imbalance, according to Southeastern Medical Oncology Center. Diseases such as cancer and lupus can also lead to thick blood. Continue Reading.
Thick Blood: Common Causes. Certain ethnic races (particularly Caucasian) may have a genetic predisposition towards thick blood. Defects in the coagulation genes adversely affect the capability of the body to turn off the switch that activates the clotting process.