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This condition can be caused by certain medications and by infections. In some cases, it is caused by a cancer or precancerous condition. Myelofibrosis, bone marrow scarring that can result from various hematologic cancers, typically leads to low blood counts. Pancytopenia can also be caused by aplastic anemia, a bone marrow failure disorder that affects blood cell production.
Low blood count of the red blood cells usually results in anemia. Anemia from multiple myeloma may cause weakness, shortness of breath and dizziness. Decreased red blood cell count is present in approximately 60% of patients at the time of diagnosis. Anemia may be treated with supplements, medications, or transfusions.