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1 Ghrelin is secreted by endocrine cells in the stomach, especially when one is hungry and. 2  acts on the hypothalamus to stimulate feeding. 3  This action counteracts the inhibition of feeding by leptin and PYY3-36. Ghrelin is secreted by endocrine cells in the stomach, especially when one is hungry and. 2  acts on the hypothalamus to stimulate feeding. 3  This action counteracts the inhibition of feeding by leptin and PYY3-36.
While ghrelin is an appetite-stimulating peptide, leptin is an appetite-suppressing one. Ghrelin, secreted from the stomach, particularly influences the metabolism of fat tissue by promoting its storage during hard times.Leptin and ghrelin function interdependently in healthy humans.eptin is produced in the fat cells and released in the brain. Leptin gives us a feeling of satisfaction. While ghrelin enhances appetite, leptin acts as a satiety signal to diminish it. Yet, itâs not that simple.