As folate is vital in the first trimester of pregnancy for healthy fetal development, the use of antifolates is strongly contraindicated in pregnancy and carries significant teratogenic risk. Low doses of methotrexate can deplete folate stores and cause side-effects that are similar to folate deficiency.
Cause of Adult Mumps. Adult mumps is caused by an infection with the mumps virus, which is found worldwide. The mumps virus is an RNA (ribonucleic acid) virus from the family Paramyxovirus of the genus Rubulavirus. The mumps virus only infects humans.
Mumps virus causes an acute disease most common in children and young adults. It is transmitted by direct or close person-to-person contact, and school children are the main source of the spread. The pathogen is transmitted by salivary gland secretions, mainly just before and shortly after clinical onset (Baron, 1996).