Webster Dictionary(5.00 / 1 vote)Rate this definition: 1  Lode(noun) a water course or way; a reach of water. 2  Lode(noun) a metallic vein; any regular vein or course, whether metallic or not.
An anticholinergic medication may be recommended to reduce symptoms of bothersome tremor in people with Parkinson disease under age 70 who do not have significant akinesia or difficulty walking. Anticholinergics may be given alone, or with levodopa or dopamine agonists in people with more advanced disease who have a persistent tremor.
Catechol-O -methyl transferase (COMT) inhibitors inhibitors such as entacapone and tolcapone may be used to increase the peripheral half-life of levodopa, thereby delivering more levodopa to the brain over a longer time. Anticholinergic medications can be used for the treatment of resting tremor. However, they are not particularly effective for bradykinesia, rigidity, gait disturbance, or other features of advanced Parkinson disease; and cognitive side effects are common.