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1 Insulin sensitivity is increased, so your cells are better able to use any available insulin to take up glucose during and after activity. 2  When your muscles contract during activity, it stimulates another mechanism that is completely separate of insulin.
Physical activity. Exercise or just increasing exertion can lead to altering blood glucose levels: 1  Physical activity can affect insulin sensitivity for up to 48 hours-which can lead to lower blood sugars over this time. 2  Sugar levels can initially rise following a short burst of activity.xercise or just increasing exertion can lead to altering blood glucose levels: 1  Physical activity can affect insulin sensitivity for up to 48 hours-which can lead to lower blood sugars over this time.