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High BUN indicates increased protein breakdown, which is associated with decreased immune function. A study shows that patients with elevated BUN (> 20 mg/dl) have an increased risk of infection (R). High BUN is associated with increased mortality in critically ill patients (R, R, R, R).
1 Dehydration generally causes BUN levels to rise more than creatinine levels. 2  This causes a high BUN-to-creatinine ratio. 3  Kidney disease or blocked urine flow from your kidney causes both BUN and creatinine levels to rise.hese tests are done: 1  To see if your kidneys are working normally. 2  To find out if your kidney disease is changing. 3  To see how well the kidneys work in people who take medicines that can cause kidney damage. 4  To check for severe dehydration.