In enzymes, some of these amino acids form a site in the structure that catalyzes the enzymatic reaction. This site, called the active site of the enzyme, has amino acids that bind specifically to the substrate molecule, also called a ligand (Fig. 2). In a similar manner, certain sites in cell receptor proteins bind to specific ligand molecules that the receptor recognizes.
When did France's second empire end? The Second Empire ended with the swift and catastrophic defeat of  France in the Franco-Prussian war of 1870. The war was engineered  by Bismarck with the idea that Germany â¦would be united.This  included the capture by the Prussians of the Napoleon III. Then the  proclamation at Versailles of the German Empire, the loss to France  of Alsace and Lorraine, and the proclamation of the Third Republic.
The empire was developed as the Roman Republic invaded and occupied most of Europe and portions of northern Africa and western Asia. Under the republic, regions of the empire were ruled by provincial governors answerable to and authorised by the  Senate and People of Rome .Rome and its senate were ruled by a variety of magistrates â of whom the consuls were the most powerful.n the late 3rd century, after the Crisis of the Third Century, Diocletian formalised and embellished the recent manner of imperial rule, establishing the so-called ' Dominate ' period of the Roman Empire.