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High BUN indicates increased protein breakdown, which is associated with decreased immune function. A study shows that patients with elevated BUN (> 20 mg/dl) have an increased risk of infection (R). High BUN is associated with increased mortality in critically ill patients (R, R, R, R).
An elevated BUN may be caused by: 1  Impaired renal function. 2  Congestive heart failure as a result of poor renal perfusion. 3  Dehydration. Shock.  Hemorrhage into the gastrointestinal 1  tract. Acute myocardial infarction. 2  Stress. Excessive protein intake or protein catabolism.