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This condition can be caused by certain medications and by infections. In some cases, it is caused by a cancer or precancerous condition. Myelofibrosis, bone marrow scarring that can result from various hematologic cancers, typically leads to low blood counts. Pancytopenia can also be caused by aplastic anemia, a bone marrow failure disorder that affects blood cell production.
WBCs and all other blood cells are made in the bone marrow, so radiation to bones, especially as a child, can cause chronic suppression of blood cell production and low counts (1). Most cancer patients, however, will recover their WBC much more quickly.