An excellent example of such confusion is the present day remembrance of George Washingtonâs Birthday. The third Monday of February has legally been designated by the United Statesâ Congress as a day to remember the birthday of George Washington and some calendars will accurately designate it so.
The text above is a follow-up to ... -----Question-----. after taking a 80mg dose of methodone how long does it take for the effects to reach there peak or there maximum effect. -----Answer-----. Dear Charles, It takes about 4 hours for methadone to reach its peak concentration following oral administration. Some relief of pain occurs after 30 to 60 minutes and the duration of action is initially 6 to 8 hours.
800 mg taken at once will make you reach a higher peak serum drug level, so at that moment is more effective against pain, but it wonât last that long, T1/2 that is the time it takes to half the serum level is just 2 hours; 4 times over the day 200 mg would have a much lower serum drug level over the day, so less pain killing for a longer time.