Polycystic kidney disease (PKD or PCKD, also known as polycystic kidney syndrome) is a genetic disorder in which abnormal cysts develop and grow in the kidneys. Cystic disorders can express themselves at any point, infancy, childhood, or adulthood.The disease occurs in humans and some other animals.PKD is characterized by the presence of multiple cysts (hence, polycystic) typically in both kidneys; however, 17% of cases initially present with observable disease in one kidney, with most cases progressing to bilateral disease in adulthood.utosomal dominant polycystic kidney disease (ADPKD) is the most common of all the inherited cystic kidney diseases with an incidence of 1:500 live births. Studies show that 10% of end-stage kidney disease (ESKD) patients being treated with dialysis in Europe and the U.S. were initially diagnosed and treated for ADPKD.
The Sacramento River is the largest river and watershed system in California (by discharge, it is the second largest U.S. river draining into the Pacific, after the Columbia River).
The Mokelumne River /mÉËkÊlÉmni/ is a 95-mile (153 km)-long river in northern California in the United States.The river flows west from a rugged portion of the central Sierra Nevada into the Central Valley and ultimately the SacramentoâSan Joaquin River Delta, where it empties into the San Joaquin River.he confluence of the North and Middle Forks forms the Mokelumne River proper. The main stem flows west-southwest past Mokelumne Hill into Pardee Reservoir, formed by the 345-foot (105 m)-high Pardee Dam.