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Lack of evidence: There is little evidence to suggest that low dose Seroquel is an effective treatment for insomnia. Despite the drugâs perception of being an effective treatment for insomnia, there is minimal evidence in support of these claims.
1 These drugs may be used to treat parasomnias. Occasionally, they are also used to treat bruxism (teeth grinding) and short-term insomnia.  Non-benzodiazepine hypnotics, such as zolpidem (Ambien), zaleplon (Sonata), and eszopiclone (Lunesta); these drugs are used to treat short-term insomnia.