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This condition can be caused by certain medications and by infections. In some cases, it is caused by a cancer or precancerous condition. Myelofibrosis, bone marrow scarring that can result from various hematologic cancers, typically leads to low blood counts. Pancytopenia can also be caused by aplastic anemia, a bone marrow failure disorder that affects blood cell production.
Excessive numbers of white blood cells are most often due to the response of normal bone marrow to infection or inflammation. In some instances, leukocytosis is a sign of more serious primary bone marrow disease (leukemias or myeloproliferative disorders).yelofibrosis is a bone marrow disorder in which fibroblasts replace normal elements of the marrow. Patients with myelofibrosis are usually 50 years or older and have a median survival of less than 10 years.