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1 Ghrelin is secreted by endocrine cells in the stomach, especially when one is hungry and. 2  acts on the hypothalamus to stimulate feeding. 3  This action counteracts the inhibition of feeding by leptin and PYY3-36. Ghrelin is secreted by endocrine cells in the stomach, especially when one is hungry and. 2  acts on the hypothalamus to stimulate feeding. 3  This action counteracts the inhibition of feeding by leptin and PYY3-36.
Reviewed: December 2014. Ghrelin is a hormone that is produced and released mainly by the stomach with small amounts also released by the small intestine, pancreas and brain.Ghrelin has numerous functions. It is termed the âhunger hormoneâ because it stimulates appetite, increases food intake and promotes fat storage.hrelin is produced by the stomach. Among its numerous functions, ghrelin increases appetite and stimulates the release of growth hormone.