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1 Ghrelin is secreted by endocrine cells in the stomach, especially when one is hungry and. 2  acts on the hypothalamus to stimulate feeding. 3  This action counteracts the inhibition of feeding by leptin and PYY3-36. Ghrelin is secreted by endocrine cells in the stomach, especially when one is hungry and. 2  acts on the hypothalamus to stimulate feeding. 3  This action counteracts the inhibition of feeding by leptin and PYY3-36.
The ghrelin receptor, GH secretagogue receptor type 1a (GHS-R1a), is a G-protein coupled receptor that is widely expressed. Within the CNS, it is found in areas involved in the regulation of appetite and energy balance, including the hypothalamic nuclei, dorsal vagal complex, and mesolimbic dopaminergic system. Ghrelin has multiple effects, including stimulation of GH, ACTH, cortisol, aldosterone, catecholamine, and prolactin secretion.