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High BUN indicates increased protein breakdown, which is associated with decreased immune function. A study shows that patients with elevated BUN (> 20 mg/dl) have an increased risk of infection (R). High BUN is associated with increased mortality in critically ill patients (R, R, R, R).
Increased blood urea nitrogen ( BUN ) may be due to prerenal causes ( cardiac decompensation , water depletion due to decreased intake and excessive loss , increased protein catabolism , and high protein diet ) , renal causes ( acute glomerulonephritis , chronic nephritis , polycystic kidney disease , nephrosclerosis , and tubular necrosis ) and ...