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High BUN indicates increased protein breakdown, which is associated with decreased immune function. A study shows that patients with elevated BUN (> 20 mg/dl) have an increased risk of infection (R). High BUN is associated with increased mortality in critically ill patients (R, R, R, R).
An increase in the BUN level is known as azotemia. An elevated BUN may be caused by: 1  Impaired renal function. 2  Congestive heart failure as a result of poor renal perfusion. 3  Dehydration.