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High BUN indicates increased protein breakdown, which is associated with decreased immune function. A study shows that patients with elevated BUN (> 20 mg/dl) have an increased risk of infection (R). High BUN is associated with increased mortality in critically ill patients (R, R, R, R).
High blood pressure. High blood pressure is another symptom that occurs when BUN is elevated. For kidney disease patients, BUN is elevated as kidney function is impaired seriously, and in that case, they may experience various symptoms.. Tiredness. Kidney disease patients with elevated BUN may find they become tired easily and this is usually caused by renal anemia which is diagnosed when red blood cell account is lower than the normal range due to kidney disease. 4. Foamy urine. Foamy urine is the clinical manifestation of proteinuria.