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High BUN indicates increased protein breakdown, which is associated with decreased immune function. A study shows that patients with elevated BUN (> 20 mg/dl) have an increased risk of infection (R). High BUN is associated with increased mortality in critically ill patients (R, R, R, R).
BUN (Blood urea nitrogen) is used as a measure of the kidneyâs ability to remove waste products. High levels are seen in kidney disease, but can also be increased by dehydration, high-protein diets and strenuous exercise. Low levels may be seen in pregnancy, low-protein diets, over hydration or liver disease.