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Wiktionary (0.00 / 0 votes) Rate this definition: disease (Noun). An abnormal condition of the body or mind that causes discomfort or dysfunction; distinct from injury insofar as the latter is usually instantaneously acquired. The tomato plants had some kind of disease that left their leaves splotchy and fruit withered. disease (Noun). Any abnormal or harmful condition, as of society, people's attitudes, way of living etc. disease (Verb). To cause unease; to annoy, irritate. disease (Verb). To infect with a disease.
disease. noun. 1  An abnormal condition of a part, organ, or system of an organism resulting from various causes, such as infection, inflammation, environmental factors, or genetic defect, and characterized by an identifiable group of signs, symptoms, or both.isease. 1  any departure from health; illness in general. 2  a particular destructive process in an organ or organism, with a specific cause and characteristic symptoms; specif., an illness; ailment. 3  any harmful or destructive condition, as of society.