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This condition can be caused by certain medications and by infections. In some cases, it is caused by a cancer or precancerous condition. Myelofibrosis, bone marrow scarring that can result from various hematologic cancers, typically leads to low blood counts. Pancytopenia can also be caused by aplastic anemia, a bone marrow failure disorder that affects blood cell production.
Low blood count is a common characteristic of multiple myeloma which contributes to a number of multiple myeloma symptoms. Myeloma plasma cells interfere with the production of all other types of blood cells. This often results in a low blood count for both red blood cells as well as white blood cells.