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1 Ghrelin is secreted by endocrine cells in the stomach, especially when one is hungry and. 2  acts on the hypothalamus to stimulate feeding. 3  This action counteracts the inhibition of feeding by leptin and PYY3-36. Ghrelin is secreted by endocrine cells in the stomach, especially when one is hungry and. 2  acts on the hypothalamus to stimulate feeding. 3  This action counteracts the inhibition of feeding by leptin and PYY3-36.
If your stomach is growling, then it is producing ghrelin. Ghrelin communicates with your brain and triggers the release of an additional hormone called neuropeptide Y, which is a hormone secreted by the hypothalamus to stimulate hunger. Your hypothalamus is the part of your brain that regulates appetite and hunger. It receives input from the vagus nerve, which is a cranial nerve that sends signals from the gastrointestinal tract to the brain and reports on how distended your stomach is.