Manuel I of Portugal
Manuel's mother was the granddaughter of King John I of Portugal, whereas his father was the second surviving son of King Edward of Portugal and the younger brother of King Afonso V of Portugal. In 1495, Manuel succeeded his first cousin, King John II of Portugal, who was also his brother-in-law, as husband to Manuel's sister, Eleanor of Viseu.
Descendants of Manuel I of Portugal
After King Manuel's death, his descendants would hold a great importance to Portuguese sovereignty and European history. Almost all of Manuel's descendants would become crucial beings in the Portuguese succession crisis of 1580, the Iberian Union, and later the Portuguese Restoration War, as all the claims to the Portuguese throne during these events originated from descendancy from Manuel I.