Ridley (Metroid)
Often considered one of the most memorable Nintendo villains, Ridley has been a mainstay of the series, having appeared (through various incarnations) in almost every "Metroid" game to date (all but "", "Metroid Prime Hunters" and ""). He has also appeared in the "Super Smash Bros." series, however, he had not been made a playable character until "Super Smash Bros. Ultimate" in 2018, making it also the first game overall to have Ridley as a playable character.
Transformers: Prime
The Decepticons are led by Megatron (Frank Welker), who is the main antagonist throughout the series. Initially, he is assisted by his loyal follower the silent Soundwave, and the treacherous Starscream (Steven Blum) who wishes to usurp him. Later, they are joined by Knock Out (Daran Norris)—the Decepticons' medic—and his partner Breakdown (Adam Baldwin), who has an ugly past and a rivalry with Bulkhead. Soon afterward, Airachnid (Gina Torres) comes into play as well; before her introduction, she had killed Arcee's first partner Tailgate.