Ridley (Metroid)
One of Adam's final missions to Samus is to finish off Ridley, whom Adam fears might be more dangerous than the Metroids if left unchecked, and claims Samus is the only one capable of stopping him. However, Samus later discovers his corpse after he is killed, having had his energy drained by the Queen Metroid on the Bottle Ship. His mummified corpse turns up again in "Metroid Fusion" on the BSL station, after having apparently been removed from the Bottle Ship by the Galactic Federation and placed in a sub-zero storage room for further research (potentially into further bioweapon applications). It is later infected by an X Parasite, allowing it to gain the ability to transform into Ridley's likeness, known as . Samus later defeats the Ridley mimic and absorbs its Core-X, regaining her signature Screw Attack. What was left of the cloned Ridley's remains were destroyed along with the X when the BSL station crashed into SR388.
Dr. Wily
"Computerworld" named Wily as one of gaming's "baddest villains", praising his persistence despite his failure at the conclusion of each "Mega Man" game. 1UP.com editor Jeremy Parish shared the sentiment, stating "the fact that his schemes ultimately boil down to creating eight themed robots with a fatal weakness to one another's powers casts his 'genius' descriptor into doubt. Still, you have to admire his persistence." GameDaily named him one of their favorite older characters in video games and one of the "Top 25 Evil Masterminds of All Time", ranking him second on their list while stating "using good robots to do bad things is sheer genius." They additionally cited his rivalry with Mega Man as one of the ten greatest in video games, describing it as one "still going strong to this day." In a later article, they listed the "evil mastermind" as one of their top 25 video game archetypes, using Wily as an example. IGN listed him as the 13th Best Video Game Villain, calling him one of the most "hopelessly persistent" video game villains.