Ridley (Metroid)
Ridley returns in his Meta form once again in "", where he, along with the Space Pirate legion under his command, are corrupted by Dark Samus. He encounters and battles Samus on Norion, a Galactic Federation-occupied world, and the two fight while free-falling down an air shaft. Ridley is later supercharged with Phazon, becoming "Omega Ridley", and is charged with guarding the Leviathan Seed on the Space Pirate homeworld. He is confronted once again by Samus, and despite being defeated, he survives the fight and is later cured of his corruption after Dark Samus' defeat later on. Between the "Prime" trilogy and "", the Space Pirates reorganize on Zebes and hatch another plan to clone and weaponize the Metroids, while Ridley gradually begins to regenerate from his past injuries, gradually shedding his cybernetics. In the remake of the second game, "", Ridley, in his semi-regenerated form of "Proteus Ridley", attacks Samus on SR388 to steal the last remaining Metroid. Samus and the baby Metroid work together to defeat Ridley.
Spider-Man (Insomniac Games)
Spider-Man's mission to protect the city brings him into conflict with several supervillains, beginning with his longtime foe Wilson Fisk (Travis Willingham), the Kingpin of crime in New York, and a supernaturally powered, demonic-mask wearing gang called the Demons who begin carving up the city for the powerful Mr. Negative, who can corrupt people through his touch. Spider-Man must also confront Electro (Josh Keaton), Rhino (Fred Tatasciore), Scorpion (Jason Spisak), Vulture (Dwight Schultz),Shocker (Dave B. Mitchell), Taskmaster (Brian Bloom), Screwball (Stephanie Lemelin), and Tombstone (Corey Jones).