Early modern period
In the early modern period, the Holy Roman Empire was a union of territories in Central Europe under a Holy Roman Emperor the first of which was Otto I. The last was Francis II, who abdicated and dissolved the Empire in 1806 during the Napoleonic Wars. Despite its name, for much of its history the Empire did not include Rome within its borders.
Domus Aurea (Antioch)
Julian moved to Antioch in 362, soon after becoming the sole ruler of the eastern empire, following the death of Constantius II. He was the last non-Christian ruler of the Roman Empire, and chose Antioch as his headquarters, partly to lay plans for his proposed campaign against the Persians and partly to further his attempt to restore the eastern empire to Hellenism. He had the body of Saint Babylas removed from the martyrium near the temple of Apollo at Daphne, because he thought that it had silenced the oracle of Apollo. When the temple burned down, shortly thereafter, Julian was furious, suspecting the Christians and in response closed the Great Church, removing its liturgical vessels. This act effectively brought his attempts to restore Hellenism in Antioch to an end.