Manuel I of Portugal
Manuel's mother was the granddaughter of King John I of Portugal, whereas his father was the second surviving son of King Edward of Portugal and the younger brother of King Afonso V of Portugal. In 1495, Manuel succeeded his first cousin, King John II of Portugal, who was also his brother-in-law, as husband to Manuel's sister, Eleanor of Viseu.
Manuel I of Trebizond
Manuel I Megas Komnenos (Greek: Μανουήλ Α΄ Μέγας Κομνηνός, "Manouēl I Megas Komnēnos") (died March 1263) was an Emperor of Trebizond, from 1238 until his death. At the time Manuel reigned, the Empire of Trebizond comprised a band of territory stretching along the southern coast of the Black Sea. Although Michael Panaretos, a 14th-century Greek chronicler, calls Manuel "the greatest general and the most fortunate" and states he ruled "virtuously in the eyes of God", the only event he documents for Manuel's reign is a catastrophic fire striking the city of Trebizond in January 1253. The major events of his reign are known from external sources, most important of which is the recovery of Sinope in 1254, which had been lost to the Sultanate of Rum forty years before.