Ponderosa lemon
The ponderosa lemon originated in roughly 1887, and is believed to come from a chance seedling grown in Hagerstown, Maryland. It was later named and introduced to the nursery trade in 1900. Though often referred to as a cross between the lemon and citron, a recent genomic analysis showed it to solely contain pomelo ("Citrus maxima") and citron ("Citrus medica") DNA, perhaps being an F2 hybrid. Thus they cannot derive from true lemons, which have a mandarin orange component.
Citrus
In general, three "Citrus" ancestral species (pomelos, citrons, and papedas) synthesize relatively high quantities of furanocoumarins, whereas a fourth ancestral species (mandarins) is practically devoid of these compounds. Since the production of furanocoumarins in plants is believed to be heritable, the descendants of mandarins (such as sweet oranges, tangerines, and other small mandarin hybrids) are expected to have low quantities of furanocoumarins, whereas other hybrids (such as limes, grapefruit, and sour oranges) are expected to have relatively high quantities of these compounds.