Wolves as pets and working animals
Some wildlife centers housing captive wolves prohibit handlers from entering wolf enclosures if they happen to have a cold or other vulnerability which the wolves can detect. Captive wolves are generally shy and avoid eye contact with humans other than their owner, as well as not listening to any commands made by any other humans. They usually vacate rooms or hide when a new person enters the establishment. Even seemingly friendly wolves need to be treated with caution, as captive wolves tend to view and treat people as other wolves, and will thus bite or dominate people in the same situation in which they would other wolves. Ordinary pet food is inadequate, as an adult wolf needs 1–2.5 kg (2–5 lbs) of meat daily along with bones, skin and fur to meet its nutritional requirements. Wolves may defend their food against people, and react violently to people trying to remove it. The exercise needs of a wolf exceed the average dog's demand. Because of this, captive wolves typically do not cope well in urban areas. Due to their talent at observational learning, adult captive wolves can quickly work out how to escape confinement, and require constant reinforcement by caretakers or owners, which makes raising wolves difficult for people who raise their pets in an even, rather than subordinate, environment.
Origin of the domestic dog
Genetic studies indicate that the gray wolf is the closest living relative of the dog, with no evidence of any other canine species having contributed. Attempting to reconstruct the dog's lineage through the phylogenetic analysis of DNA sequences from modern dogs and wolves has given conflicting results for several reasons. Firstly, studies indicate that an extinct Late Pleistocene wolf is the nearest common ancestor to the dog, with modern wolves not being the dog's direct ancestor. Secondly, the genetic divergence between the dog and modern wolves occurred over a short period of time, so that the time of the divergence is difficult to date (referred to as incomplete lineage sorting). This is complicated further by the cross-breeding that has occurred between dogs and wolves since domestication (referred to as post-domestication gene flow). Finally, there have been only tens of thousands of generations of dogs since domestication, so that the number of mutations between the dog and the wolf are few and this makes the timing of domestication difficult to date.