Weight
In modern scientific usage, weight and mass are fundamentally different quantities: mass is an intrinsic property of matter, whereas weight is a "force" that results from the action of gravity on matter: it measures how strongly the force of gravity pulls on that matter. However, in most practical everyday situations the word "weight" is used when, strictly, "mass" is meant. For example, most people would say that an object "weighs one kilogram", even though the kilogram is a unit of mass.
Mass
Typically, the mass of objects is measured in relation to that of the kilogram, which is defined as the mass of the "international prototype kilogram" (IPK), a platinum alloy cylinder stored in an environmentally-monitored safe secured in a vault at the International Bureau of Weights and Measures in France. However, the IPK is not convenient for measuring the masses of atoms and particles of similar scale, as it contains trillions of trillions of atoms, and has most certainly lost or gained a little mass over time despite the best efforts to prevent this. It is much easier to precisely compare an atom's mass to that of another atom, thus scientists developed the atomic mass unit (or Dalton). By definition, 1 u is exactly one twelfth of the mass of a carbon-12 atom, and by extension a carbon-12 atom has a mass of exactly 12 u. This definition, however, might be changed by the proposed redefinition of SI base units, which will leave the Dalton very close to one, but no longer exactly equal to it.