Manuel I of Portugal
Manuel's mother was the granddaughter of King John I of Portugal, whereas his father was the second surviving son of King Edward of Portugal and the younger brother of King Afonso V of Portugal. In 1495, Manuel succeeded his first cousin, King John II of Portugal, who was also his brother-in-law, as husband to Manuel's sister, Eleanor of Viseu.
João Manuel, Prince of Portugal
João Manuel, Prince of Portugal () (3 June 1537 – 2 January 1554) was a Portuguese "infante" (prince), the eighth son of King John III of Portugal by his wife Catherine of Austria, daughter of Philip I of Castile and Joanna of Castile. As the heir to the throne he was styled Prince of Portugal.