Missouri
Located in Tornado Alley, Missouri also receives extreme weather in the form of severe thunderstorms and tornadoes. The most recent tornado in the state to cause damage and casualties was the 2011 Joplin tornado, which destroyed roughly one-third of the city of Joplin. The tornado caused an estimated $1–3 billion in damages, killed 159 (+1 non-tornadic), and injured over 1,000 people. It was the first EF5 to hit the state since 1957 and the deadliest in the U.S. since 1947, making it the seventh deadliest tornado in American history and 27th deadliest in the world. St. Louis and its suburbs also have a history of experiencing particularly severe tornadoes, the most recent memorable one being an EF4 tornado that damaged Lambert-St. Louis International Airport on April 22, 2011. One of the worst tornadoes in American history struck St. Louis on May 27, 1896, killing at least 255 and causing $10 mil. damage ($3.9 bil. damage in 2009) or $ in today's dollars.
Tuscaloosa, Alabama
On April 27, 2011, Tuscaloosa was hit by a wide EF4 tornado that resulted in 64 deaths, more than 1500 injuries, and massive devastation. 44 of the deaths were in Tuscaloosa alone, with the rest being in Birmingham and surrounding suburbs. The tornado's top winds were estimated by the US National Weather Service at . Officials at DCH Regional Medical alone reported treating more than 1,000 injured people in the tornado aftermath. Officials reported dozens of unaccompanied minors being admitted for treatment at the hospital, raising questions about the possible loss of their parents. Several were taken to pediatric trauma wards, indicating serious injuries. Referring to the extent and severity of the damage, Mayor Walter Maddox stated that "we have neighborhoods that have been basically removed from the map." The same tornado later went on to cause major damage in the Birmingham area. In all, the cost of damage from the tornado amounted to $2.45 billion, making it, at the time, the costliest tornado in U.S. history, though it would be surpassed less than a month later by the devastating Joplin, Missouri tornado of May 22.