Manuel I of Portugal
Manuel's mother was the granddaughter of King John I of Portugal, whereas his father was the second surviving son of King Edward of Portugal and the younger brother of King Afonso V of Portugal. In 1495, Manuel succeeded his first cousin, King John II of Portugal, who was also his brother-in-law, as husband to Manuel's sister, Eleanor of Viseu.
Afonso de Albuquerque
When King Manuel I of Portugal was enthroned, he showed some reticence towards Afonso, a close friend of his dreaded predecessor and seventeen years his senior. Eight years later, on 6 April 1503, after a long military career and at a mature age, Afonso was sent on his first expedition to India together with his cousin Francisco de Albuquerque. Each commanded three ships, sailing with Duarte Pacheco Pereira and Nicolau Coelho. They engaged in several battles against the forces of the Zamorin of Calicut ("Calecute", Kozhikode) and succeeded in establishing the King of Cohin ("Cohim", Kochi) securely on his throne. In return, the King gave them permission to build the Portuguese fort "Immanuel" (Fort Kochi) and establish trade relations with Quilon ("Coulão", Kollam). This laid the foundation for the eastern Portuguese Empire.