Royal Palace of Évora
With King John II's death, in 1495, his cousin, Manuel I, Duke of Beja and Viseu, succeeded King John II as King Manuel I of Portugal. King Manuel I's personal monopoly on the spice trade allowed the King to be a great patron of the arts, constructing numerous palaces, convents, and churches throughout the country. King Manuel I took a great interest in Évora, establishing his court there on various occasions. From 1502 to 1520, King Manuel I ordered a vast series of renovations, constructions, and enlargements. During the Manueline Campaigns, as the works are collectively known as, the palace grew to one of the largest palaces in Iberia. Through architects Martim Lourenço, Álvaro Anes, and António de Lagoa the Manuline Campaign saw the construction of Couto Hall, the Wing of the Infantes, an infirmary, the Royal Gardens and Hunting Grounds, the Royal Library, and the Gallery of Dames, which is the only part of the palace to survive to present day. Alongside expansion of the palace, King Manuel I also renovated the existing parts of the palace, remodeling the Queen's Hall, the servants quarters, and the Rossio of the Palace. In 1519, King Manuel I ordered architect André Pires to turn the plain Hall of Ambassadors into a Manueline Throne Room, which would direct itself towards the Palace Rossio.
Persecution of Jews and Muslims by Manuel I of Portugal
On 5 December 1496, because a clause of the contract of marriage between himself and Isabella, Princess of Asturias stipulated he do so in order to win her hand, King Manuel I of Portugal decreed that all Jews must convert to Catholicism or leave the country. One set of laws demonstrated the King's wish to completely and forever eradicate Judaism from Portugal. The initial edict of expulsion was turned into an edict of forced conversion in 1497: Portuguese Jews were prevented from leaving the country and forcibly converted to Christianity. 
Hard times followed for the Portuguese conversos, with the massacre of 2,000 individuals in Lisbon in 1506 and the later and even more relevant establishment of the Portuguese Inquisition in 1536. The Portuguese inquisition was extinguished in 1821 by the "General Extraordinary and Constituent Courts of the Portuguese Nation".