Cactus
Fungi, bacteria and viruses attack cacti, the first two particularly when plants are over-watered. Fusarium rot can gain entry through a wound and cause rotting accompanied by red-violet mold. ""Helminosporium" rot" is caused by "Bipolaris cactivora" ( "Helminosporium cactivorum"); "Phytophthora" species also cause similar rotting in cacti. Fungicides may be of limited value in combating these diseases. Several viruses have been found in cacti, including cactus virus X. These appear to cause only limited visible symptoms, such as chlorotic (pale green) spots and mosaic effects (streaks and patches of paler color). However, in an "Agave" species, cactus virus X has been shown to reduce growth, particularly when the roots are dry. There are no treatments for virus diseases.
Drought
Many plant species, such as those in the family Cactaceae (or cacti), have drought tolerance adaptations like reduced leaf area and waxy cuticles to enhance their ability to tolerate drought. Some others survive dry periods as buried seeds. Semi-permanent drought produces arid biomes such as deserts and grasslands. Prolonged droughts have caused mass migrations and humanitarian crisis. Most arid ecosystems have inherently low productivity. The most prolonged drought ever in the world in recorded history occurred in the Atacama Desert in Chile (400 Years).