Ridley (Metroid)
Often considered one of the most memorable Nintendo villains, Ridley has been a mainstay of the series, having appeared (through various incarnations) in almost every "Metroid" game to date (all but "", "Metroid Prime Hunters" and ""). He has also appeared in the "Super Smash Bros." series, however, he had not been made a playable character until "Super Smash Bros. Ultimate" in 2018, making it also the first game overall to have Ridley as a playable character.
Spider (pulp fiction)
Despite The Spider's tendency to kill his enemies, he encounters several foes more than once, such as The Fly and MUNRO, a master of disguise. Some storylines featuring a struggle against a single villain lasted for several consecutive issues, such as The Spider's four-part battle against The Living Pharaoh and The Spider's three-part battle against The Master and his Black Police. Among the enemies he encountered just once were predecessors of the costumed super villains of comic books, such as Judge Torture, Red Feather, The Bloody Serpent, The Brain, The Emperor of Vermin, The Red Mandarin, The Silencer, and The Wreck. The names of two Spider villains, The Bat Man and The Iron Man, were later adopted for DC and Marvel comic book superheroes.