Manuel I of Portugal
Manuel's mother was the granddaughter of King John I of Portugal, whereas his father was the second surviving son of King Edward of Portugal and the younger brother of King Afonso V of Portugal. In 1495, Manuel succeeded his first cousin, King John II of Portugal, who was also his brother-in-law, as husband to Manuel's sister, Eleanor of Viseu.
Maria I of Portugal
Dona Maria I (English: "Mary I"; 17 December 1734 – 20 March 1816) was Queen of Portugal from 1777 until her death. Known as Maria the Pious in Portugal and Maria the Mad in Brazil, she was the first undisputed queen regnant of Portugal and the first monarch of Brazil. With Napoleon's European conquests, her court, then under the direction of her son João, the Prince Regent, moved to Brazil, then a Portuguese colony. Later on, Brazil would be elevated from the rank of a colony to that of a kingdom, with the consequential formation of the United Kingdom of Portugal, Brazil and the Algarves.