Manuel I of Portugal
Manuel's mother was the granddaughter of King John I of Portugal, whereas his father was the second surviving son of King Edward of Portugal and the younger brother of King Afonso V of Portugal. In 1495, Manuel succeeded his first cousin, King John II of Portugal, who was also his brother-in-law, as husband to Manuel's sister, Eleanor of Viseu.
Cardinal-Infante Afonso of Portugal
Cardinal-Infante Afonso (23 April 1509–21 April 1540; ; ) was a Portuguese "infante" (prince), son of King Manuel I of Portugal and his wife Maria of Aragon.