Manuel I of Portugal
Manuel's mother was the granddaughter of King John I of Portugal, whereas his father was the second surviving son of King Edward of Portugal and the younger brother of King Afonso V of Portugal. In 1495, Manuel succeeded his first cousin, King John II of Portugal, who was also his brother-in-law, as husband to Manuel's sister, Eleanor of Viseu.
Manuel Pessanha
Manuel Pessanha (Portuguese translation of Italian Emanuele Pessagno) was a Genoese merchant sailor who served in Portugal in the 14th century as the first admiral of Portugal at the time of King Denis of Portugal. His brother was Antonio Pessagno.