Ischemia
The word "ischemia" () is from Greek ἴσχαιμος "iskhaimos", "staunching blood" from ἴσχω "iskhο", "keep back, restrain" and αἷμα "haima", "blood".
Threshold potential
Abnormalities in neuronal excitability have been noted in amyotrophic lateral sclerosis and diabetes patients. While the mechanism ultimately responsible for the variance differs between the two conditions, tests through a response to ischemia indicate a similar resistance, ironically, to ischemia and resulting paresthesias. As ischemia occurs through inhibition of the sodium-potassium pump, abnormalities in the threshold potential are hence implicated.