Manuel I of Portugal
Manuel's mother was the granddaughter of King John I of Portugal, whereas his father was the second surviving son of King Edward of Portugal and the younger brother of King Afonso V of Portugal. In 1495, Manuel succeeded his first cousin, King John II of Portugal, who was also his brother-in-law, as husband to Manuel's sister, Eleanor of Viseu.
Manuel I of Portugal
Negotiations for a marriage between Manuel and Elizabeth of York in 1485 were halted by the death of Richard III of England. He went on to marry three times. His first wife was Isabella of Aragon, princess of Spain and widow of the previous Prince of Portugal Afonso. Next, he married another princess of Spain, Maria of Aragon (his first wife's sister), and then Eleanor of Austria, a niece of his first two wives who married Francis I of France after Manuel's death.