Ridley (Metroid)
Often considered one of the most memorable Nintendo villains, Ridley has been a mainstay of the series, having appeared (through various incarnations) in almost every "Metroid" game to date (all but "", "Metroid Prime Hunters" and ""). He has also appeared in the "Super Smash Bros." series, however, he had not been made a playable character until "Super Smash Bros. Ultimate" in 2018, making it also the first game overall to have Ridley as a playable character.
Spider-Man (Insomniac Games)
Spider-Man's mission to protect the city brings him into conflict with several supervillains, beginning with his longtime foe Wilson Fisk (Travis Willingham), the Kingpin of crime in New York, and a supernaturally powered, demonic-mask wearing gang called the Demons who begin carving up the city for the powerful Mr. Negative, who can corrupt people through his touch. Spider-Man must also confront Electro (Josh Keaton), Rhino (Fred Tatasciore), Scorpion (Jason Spisak), Vulture (Dwight Schultz),Shocker (Dave B. Mitchell), Taskmaster (Brian Bloom), Screwball (Stephanie Lemelin), and Tombstone (Corey Jones).