Madelyne Pryor
Madelyne Pryor was introduced during the acclaimed 1983 "Uncanny X-Men" run that saw long-time writer Chris Claremont pair with artist Paul Smith for a series of issues that would see the Jean Grey look-alike marry the retired X-Men leader Scott Summers (Cyclops).
Patsy Walker
Patsy and Hedy made a cameo appearance in "Fantastic Four Annual" #3 (1965), establishing them in the Marvel Universe. The superhero-team comic "The Defenders" #89 (Nov. 1980) further established that the earlier stories were fictional works published within the fictional Marvel Universe itself, and written by Patsy's mother Dorothy Walker though based upon Patsy's own life and friends. The Patsy Walker profile in "Marvel Legacy: The 1960s Handbook" #1 (2006) establishes that Walker indeed experienced many of the events from these stories.