Hydrophis belcheri
Belcher's sea snake, which many times is mistakenly called the "hook-nosed sea snake" ("Enhydrina schistosa"), has been erroneously popularized as the most venomous snake in the world, due to Ernst and Zug's published book "Snakes in Question: The Smithsonian Answer Book" from 1996.
Associate Professor Bryan Grieg Fry, a prominent venom expert, has clarified the error: "The hook nosed myth was due to a fundamental error in a book called 'Snakes in question'. In there, all the toxicity testing results were lumped in together, regardless of the mode of testing (e.g. subcutaneous vs. intramuscular vs intravenous vs intraperitoneal). As the mode can influence the relative number, venoms can only be compared within a mode. Otherwise, its apples and rocks.". Studies on mice and human cardiac cell culture shows that venom of the inland taipan, drop by drop, is the most toxic among all snakes; land or sea. The most venomous sea snake is actually Dubois' seasnake ("Aipysurus duboisii" ).
List of dangerous snakes
The most medically important species of snake bites in Central Asia is the Caspian cobra ("Naja oxiana"). It is the most venomous species of cobra in the world, slightly ahead of the Philippines cobra based on a toxinological study from 1992 found in the Indian Journal of Experimental Biology, in which this species produced the highest potency venom among cobras. The venom of this species has the most potent composition of toxins found among any cobra species known. It is made up of primarily highly potent neurotoxins but it also has cytotoxic activity (tissue-death, necrosis) and cardiotoxins. Two forms of "cytotoxin II" (cardiotoxin) were found in the venom of this species. The crude venom of this species produced the lowest known lethal dose (LCLo) of 0.005 mg/kg, the lowest among all cobra species, derived from an individual case of poisoning by intracerebroventricular injection. A 1992 extensive toxinology study gave a value of 0.18 mg/kg (range of 0.1 mg/kg - 0.26 mg/kg) by subcutaneous injection. According to Brown (1973), the subcutaneous value is 0.4 mg/kg, while Ernst and Zug "et al." list a value of 0.21 mg/kg SC and 0.037 mg/kg IV. Latifi (1984) listed a subcutaneous value of 0.2 mg/kg. In another study, where venom was collected from a number of specimens in Iran, the IV in lab mice was 0.078 mg/kg. Average venom yield per bite for this species is between 75 and 125 mg (dry weight), but it may yield up to 590 mg (dry weight) in a single bite. The bite of this species may cause severe pain and swelling, along with severe neurotoxicity. Weakness, drowsiness, ataxia, hypotension, and paralysis of throat and limbs may appear in less than one hour after the bite. Without medical treatment, symptoms rapidly worsen and death can occur rapidly after a bite due to respiratory failure. An adult woman bitten by this species in northwestern Pakistan suffered severe neurotoxicity and died while en route to the closest hospital nearly 50 minutes after envenomation. Between 1979 and 1987, 136 confirmed bites were attributed to this species in the former Soviet Union. Of the 136, 121 received antivenom, and only four died. Of the 15 who did not receive antivenom, 11 died. This species is an abundant snake in northeastern Iran and is responsible for a very large number of snakebite mortalities. Antivenom is not as effective for envenomation by this species as it is for other Asiatic cobras within the same region, like the Indian cobra ("Naja naja") and due to the dangerous toxicity of this species' venom, massive amounts of antivenom are often required for patients. As a result, a monovalent antivenom serum is being developed by the Razi Vaccine and Serum Research Institute in Iran. The untreated mortality rate for this species is 70-75%, which is the highest among all cobra species of the genus "Naja".