Muhammad
Muhammad's life is traditionally defined into two periods: pre-hijra (emigration) in Mecca (from 570 to 622), and post-hijra in Medina (from 622 until 632). Muhammad is said to have had thirteen wives in total (although two have ambiguous accounts, Rayhana bint Zayd and Maria al-Qibtiyya, as wife or concubine.) Eleven of the thirteen marriages occurred after the migration to Medina.
Safiye Sultan
Safiye had been Murad's only concubine prior to his accession, and he continued having a monogamous relationship with her for several years into his sultanate. His mother Nurbanu advised him to take other concubines for the good of the dynasty, which by 1581 had only one surviving heir, Murad and Safiye's son Mehmed. In 1583, Nurbanu accused Safiye of using witches and sorcerers to render Murad impotent and prevent him from taking new concubines. This resulted in the imprisonment and torture of Safiye's servants. Murad's sister Esmehan presented him with two beautiful concubines, which he accepted. Cured of his impotence, he went on to father twenty sons and twenty-seven daughters.