Manuel I of Portugal
Manuel's mother was the granddaughter of King John I of Portugal, whereas his father was the second surviving son of King Edward of Portugal and the younger brother of King Afonso V of Portugal. In 1495, Manuel succeeded his first cousin, King John II of Portugal, who was also his brother-in-law, as husband to Manuel's sister, Eleanor of Viseu.
Miguel I of Portugal
In 1807, at the age of 5, Miguel accompanied the Portuguese Royal Family on their transfer to Brazil in order to escape from the first Napoleonic invasion of Portugal; he returned in 1821 with João VI and his mother, while his brother Peter remained behind as regent of Brazil.