Basal-cell carcinoma
Basal-cell cancer is a very common skin cancer. It is much more common in fair-skinned individuals with a family history of basal-cell cancer and increases in incidence closer to the equator or at higher altitude. There are approximately 800,000 new cases yearly in the United States alone. Up to 30% of Caucasians develop basal-cell carcinomas in their lifetime. In Canada, the most common skin cancer is basal-cell carcinoma (as much as one third of all cancer diagnoses), affecting 1 in 7 individuals over a lifetime.
Basaloid squamous cell lung carcinoma
Both basaloid and squamous cell carcinomas have been shown to arise from pre-malignant lesions of dysplasia in the airways of the lung. After continued exposure to tobacco smoke or other carcinogenic stimuli, cells in areas of severe dysplasia can suffer additional genetic damage that results in progression to a basaloid or squamous cell carcinoma "in situ" (CIS). CIS is a fully malignant lesion, but by definition, the cancer cells have not yet invaded beyond the tissue delimiting their original site of genesis.