Basal-cell carcinoma
Basal-cell cancer is a very common skin cancer. It is much more common in fair-skinned individuals with a family history of basal-cell cancer and increases in incidence closer to the equator or at higher altitude. There are approximately 800,000 new cases yearly in the United States alone. Up to 30% of Caucasians develop basal-cell carcinomas in their lifetime. In Canada, the most common skin cancer is basal-cell carcinoma (as much as one third of all cancer diagnoses), affecting 1 in 7 individuals over a lifetime.
BRCA mutation
Men with a "BRCA" mutation have a dramatically elevated relative risk of developing breast cancer, but because the overall incidence of breast cancer in men is so low, the absolute risk is equal to or lower than the risk for women without a "BRCA" mutation. Approximately 1% to 2% of men with a "BRCA1" mutation will develop breast cancer by age 70. Approximately 6% of men with a "BRCA2" mutation will develop breast cancer by age 70, which is approximately equal to the risk for women without a "BRCA" mutation. Very few men, with or without a predisposing mutation, develop breast cancer before age 50.