Biochemistry
The term "biochemistry" itself is derived from a combination of biology and chemistry. In 1877, Felix Hoppe-Seyler used the term ("biochemie" in German) as a synonym for physiological chemistry in the foreword to the first issue of "Zeitschrift für Physiologische Chemie" (Journal of Physiological Chemistry) where he argued for the setting up of institutes dedicated to this field of study. The German chemist Carl Neuberg however is often cited to have coined the word in 1903, while some credited it to Franz Hofmeister.
It was once generally believed that life and its materials had some essential property or substance (often referred to as the "vital principle") distinct from any found in non-living matter, and it was thought that only living beings could produce the molecules of life. Then, in 1828, Friedrich Wöhler published a paper on the synthesis of urea, proving that organic compounds can be created artificially. Since then, biochemistry has advanced, especially since the mid-20th century, with the development of new techniques such as chromatography, X-ray diffraction, dual polarisation interferometry, NMR spectroscopy, radioisotopic labeling, electron microscopy, and molecular dynamics simulations. These techniques allowed for the discovery and detailed analysis of many molecules and metabolic pathways of the cell, such as glycolysis and the Krebs cycle (citric acid cycle), and led to an understanding of biochemistry on a molecular level. Philip Randle is well-known for his discovery in diabetes research is possibly the glucose-fatty acid cycle in 1963.He confirmed that fatty acids reduce oxidation of sugar by the muscle. High fat oxidation was responsible for the insulin resistance.
Department of Biochemistry, University of Oxford
The Department of Biochemistry at Oxford University began as the physiological chemistry section of the Physiology Department, and acquired its own separate department and building in the 1920s. In 1920, Benjamin Moore was elected to the position of the Whitley Professor of Biochemistry, the newly established Chair of Biochemistry at Oxford University. He was followed by Rudolph Peters in 1923, and an endowment of £75,000 was soon granted by the Rockefeller Foundation for the construction of a new building for the Department of Biochemistry, purchase of its equipment, and its maintenance. The Biochemistry Department building opened in 1927.
In 1954, Hans Krebs was appointed the Whitley Chair of Biochemistry, and his appointment brought greater prominence to the department. He brought with him the Medical Research Council unit established to conduct research on cell metabolism. In 1955, a second professorship in the department, the Iveagh Chair of Microbiology, was established with funding from Guinness and the sub-department of Microbiology created, with Donald Woods its first holder. The eight-storey Hans Krebs Building was constructed in 1964 with funds from the Rockefeller Foundation. Krebs was succeeded by Rodney Porter in 1967. Genetics was brought into the Biochemistry Department when Walter Bodmer was appointed the first Professor of Genetics in 1970. The Laboratory of Molecular Biophysics, first established in the Zoology Department with support from Krebs and also linked to the Physical Chemistry Laboratory of the Chemistry Department, became part of the Biochemistry Department. It moved into the Rex Richards building built in 1984, with David Phillips the Professor in Molecular Biophysics. The Oxford Glycobiology Institute, then headed by Raymond Dwek and housed in the Rodney Porter Building, opened in 1991.