Glutamate (neurotransmitter)
Glutamate is a major constituent of a wide variety of proteins; consequently it is one of the most abundant amino acids in the human body. Under ordinary conditions enough is obtained from the diet that there is no need for any to be synthesized. Nevertheless, glutamate is formally classified as a non-essential amino acid, because it can be synthesized from alpha-Ketoglutaric acid, which is produced as part of the citric acid cycle by a series of reactions whose starting point is citrate. Glutamate cannot cross the blood-brain barrier unassisted, but it is actively transported into the nervous system by a high affinity transport system, which maintains its concentration in brain fluids at a fairly constant level.
QRICH2
QRICH2 protein is 1663 amino acids long, and 10.9% of the amino acids are Glutamine (Q). 38% of the QRICH2 protein secondary structure is alpha-helix, 39% is beta-sheet and 13% is turning. The human tissue type with the highest level of QRICH2 expression is testis, and this result is confirmed by the Gene Expression Profile for mouse and dog too. The subcellular location of QRICH2 protein is in the nucleus. QRICH2 is a soluble protein, its average hydrophobicity is -0.5995. QRICH2 protein interact with a number of other proteins including SSSCA1, TSSC1, GAPDH, NUP98 and SNAI1.