Chalcedon
The site of Chalcedon is located on a small peninsula on the north coast of the Sea of Marmara, near the mouth of the Bosphorus. A stream, called the Chalcis or Chalcedon in antiquity and now known as the Kurbağalıdere (Turkish: "stream with frogs"), flows into Fenerbahçe bay. There Greek colonists from Megara in Attica founded the settlement of Chalcedon in 685 BC, some seventeen years before Byzantium.
Syriac Orthodox Church
The Christological controversies that followed the Council of Chalcedon in 451 resulted in a long struggle for the Patriarchate between those who accepted and those who rejected the Council. In 518, Patriarch Severus of Antioch was exiled from the city of Antioch and took refuge in Alexandria. Non-Chalcedonians continued to recognize Severus as the legitimate patriarch even after his exile in 518 until his death in 538. Jacob Baradeus continued to ordain patriarchs after Severus continuing the Non-Chalcedonian succession of patriarchs of the Church of Antioch, in opposition to the government-backed Patriarchate of Antioch occupied by the pro-Chalcedonian partisans, today known as Greek Orthodox Church of Antioch; leading to its being known popularly as the "Jacobite" Church while the Chalcedonian entity were known popularly as "Melkites" coming from the Syriac word for king (malka), an implication of the Chalcedonian church's relationship to the Roman Emperor. On account of many historical upheavals and consequent hardships which the church had to undergo, the Patriarchate was transferred to different monasteries in Mesopotamia for centuries.