Brain tumor
Glioblastoma multiforme (GBM) is the most aggressive (grade IV) and most common form of a malignant brain tumor. Even when aggressive multimodality therapy consisting of radiotherapy, chemotherapy, and surgical excision is used, median survival is only 12–17 months. Standard therapy for glioblastoma multiforme consists of maximal surgical resection of the tumor, followed by radiotherapy between two and four weeks after the surgical procedure to remove the cancer, then by chemotherapy, such as temozolomide. Most patients with glioblastoma take a corticosteroid, typically dexamethasone, during their illness to relieve symptoms. Experimental treatments include targeted therapy, gamma knife radiosurgery, boron neutron capture therapy and gene therapy.
Charles Whitman
Following a three-hour hearing on August 5, the Commission concluded that Chenar's finding had been in error. They found that the tumor had features of a glioblastoma multiforme, with widespread areas of necrosis, palisading of cells, and a "remarkable vascular component" described as having "the nature of a small congenital vascular malformation." Psychiatric contributors to the report concluded that "the relationship between the brain tumor and [...] Whitman's actions [...] cannot be established with clarity. However, the [...] tumor conceivably could have contributed to his inability to control his emotions and actions," while the neurologists and neuropathologists concluded: "The application of existing knowledge of organic brain function does not enable us to explain the actions of Whitman on August first."