Manuel I of Portugal
Manuel's mother was the granddaughter of King John I of Portugal, whereas his father was the second surviving son of King Edward of Portugal and the younger brother of King Afonso V of Portugal. In 1495, Manuel succeeded his first cousin, King John II of Portugal, who was also his brother-in-law, as husband to Manuel's sister, Eleanor of Viseu.
Ferdinand of Portugal, Duke of Guarda
Ferdinand of Portugal, Duke of Guarda, (5 June 1507 – 7 November 1534; ; ) was a Portuguese "infante" (prince), the son of King Manuel I of Portugal and his second wife, Maria of Aragon.