Osteoblastoma
When diagnosing osteoblastoma, the preliminary radiologic workup should consist of radiography of the site of the patient's pain. However, computed tomography (CT) is often necessary to support clinical and plain radiographic findings suggestive of osteoblastoma and to better define the margins of the lesion for potential surgery. CT scans are best used for the further characterization of the lesion with regard to the presence of a nidus and matrix mineralization. MRI aids in detection of nonspecific reactive marrow and soft tissue edema, and MRI best defines soft tissue extension, although this finding is not typical of osteoblastoma. Bone scintigraphy (bone scan) demonstrates abnormal radiotracer accumulation at the affected site, substantiating clinical suspicion, but this finding is not specific for osteoblastoma. In many patients, biopsy is necessary for confirmation.
Optical coherence elastography
Requiring no injections, OCE is an non-invasive imaging method can gives more details than ultrasound or MRI. Using light source to image biological tissue, OCE is considered generally safe compared to CT scan and other radiographic imaging modalities which involve with ionizing radiation. And it is also more affordable and time efficient compared to MRI. However, OCE can also cause tissue damage in some handling. For example, surface acoustic wave OCE can cause to a tissue is primarily concentrated on temperature effects. In the focus point, the temperature of the tissue will rise locally. Therefore, it is necessary to take this into account in certain circumstances.