Manuel I of Portugal
Manuel's mother was the granddaughter of King John I of Portugal, whereas his father was the second surviving son of King Edward of Portugal and the younger brother of King Afonso V of Portugal. In 1495, Manuel succeeded his first cousin, King John II of Portugal, who was also his brother-in-law, as husband to Manuel's sister, Eleanor of Viseu.
Persecution of Jews and Muslims by Manuel I of Portugal
On 5 December 1496, because a clause of the contract of marriage between himself and Isabella, Princess of Asturias stipulated he do so in order to win her hand, King Manuel I of Portugal decreed that all Jews must convert to Catholicism or leave the country. One set of laws demonstrated the King's wish to completely and forever eradicate Judaism from Portugal. The initial edict of expulsion was turned into an edict of forced conversion in 1497: Portuguese Jews were prevented from leaving the country and forcibly converted to Christianity. 
Hard times followed for the Portuguese conversos, with the massacre of 2,000 individuals in Lisbon in 1506 and the later and even more relevant establishment of the Portuguese Inquisition in 1536. The Portuguese inquisition was extinguished in 1821 by the "General Extraordinary and Constituent Courts of the Portuguese Nation".