Manuel I of Portugal
Manuel's mother was the granddaughter of King John I of Portugal, whereas his father was the second surviving son of King Edward of Portugal and the younger brother of King Afonso V of Portugal. In 1495, Manuel succeeded his first cousin, King John II of Portugal, who was also his brother-in-law, as husband to Manuel's sister, Eleanor of Viseu.
Maria of Aragon, Queen of Portugal
Maria of Aragon (29 June 1482 – 7 March 1517) was a Spanish infanta, and queen consort of Portugal as the second spouse of Portuguese King Manuel I.