Manuel I of Portugal
Manuel's mother was the granddaughter of King John I of Portugal, whereas his father was the second surviving son of King Edward of Portugal and the younger brother of King Afonso V of Portugal. In 1495, Manuel succeeded his first cousin, King John II of Portugal, who was also his brother-in-law, as husband to Manuel's sister, Eleanor of Viseu.
Manuel, Prince of Portugal (1531–1537)
Manuel, Prince of Portugal (11 November 1531 – 14 April 1537), was the Prince of Portugal from 1535 to his death in 1537. He was the fifth child son of king John III of Portugal and Catherine of Austria.