Manuel I of Portugal
Manuel's mother was the granddaughter of King John I of Portugal, whereas his father was the second surviving son of King Edward of Portugal and the younger brother of King Afonso V of Portugal. In 1495, Manuel succeeded his first cousin, King John II of Portugal, who was also his brother-in-law, as husband to Manuel's sister, Eleanor of Viseu.
João Manuel (bishop of Guarda)
João Manuel (Lisbon, c. 1416 – December 1476) was a religious Carmelite, Bishop of Ceuta (1443-1459) and Bishop of Guarda (1459-1476). Although some genealogists claimed that he was the son of Edward, King of Portugal and Joana Manuel de Vilhena, great-granddaughter of Juan Manuel, Prince of Villena, Anselmo Braamcamp Freire dismisses such filiation and provides sufficient arguments against it.