Inland taipan
The inland taipan is the most venomous snake in the world. Based on the median lethal dose value in mice, its venom, drop for drop, is by far the most toxic of any snake – much more so than even sea snakes – and it has the most toxic venom of any reptile when tested on human heart cell culture. Unlike most snakes, the inland taipan is a specialist mammal hunter so its venom is specially adapted to kill warm-blooded species. It is estimated that one bite possesses enough lethality to kill at least 100 fully grown men, and, depending on the nature of the bite, it has the potential to kill someone in as little as 30 to 45 minutes if left untreated. It is an extremely fast and agile snake that can strike instantly with extreme accuracy, often striking multiple times in the same attack, and it envenoms in almost every case.
Rattlesnake
The venom is hemotoxic, destroying tissue, causing necrosis and coagulopathy (disrupted blood clotting). In the U.S., the tiger rattlesnake ("C. tigris") and some varieties of the Mojave rattlesnake ("C. scutulatus") also have a presynaptic neurotoxic venom component known as Mojave type A toxin, which can cause severe paralysis. Although it has a comparatively low venom yield, the venom toxicity of "C. tigris" is considered to be among the highest of all rattlesnake venoms, and among the highest of all snakes in the Western Hemisphere based on studies conducted on laboratory mice. "C. scutulatus" is also widely regarded as producing one of the most toxic snake venoms in the Americas, based on studies in laboratory mice.