2011 Joplin tornado
Overall, the tornado killed 158 people (with an additional three indirect deaths), injured some 1,150 others, and caused damages amounting to a total of $2.8 billion. It was the deadliest tornado to strike the United States since the 1947 Glazier–Higgins–Woodward tornadoes, and the seventh-deadliest overall.
Tuscaloosa, Alabama
On April 27, 2011, Tuscaloosa was hit by a wide EF4 tornado that resulted in 64 deaths, more than 1500 injuries, and massive devastation. 44 of the deaths were in Tuscaloosa alone, with the rest being in Birmingham and surrounding suburbs. The tornado's top winds were estimated by the US National Weather Service at . Officials at DCH Regional Medical alone reported treating more than 1,000 injured people in the tornado aftermath. Officials reported dozens of unaccompanied minors being admitted for treatment at the hospital, raising questions about the possible loss of their parents. Several were taken to pediatric trauma wards, indicating serious injuries. Referring to the extent and severity of the damage, Mayor Walter Maddox stated that "we have neighborhoods that have been basically removed from the map." The same tornado later went on to cause major damage in the Birmingham area. In all, the cost of damage from the tornado amounted to $2.45 billion, making it, at the time, the costliest tornado in U.S. history, though it would be surpassed less than a month later by the devastating Joplin, Missouri tornado of May 22.