Manuel I of Portugal
Manuel's mother was the granddaughter of King John I of Portugal, whereas his father was the second surviving son of King Edward of Portugal and the younger brother of King Afonso V of Portugal. In 1495, Manuel succeeded his first cousin, King John II of Portugal, who was also his brother-in-law, as husband to Manuel's sister, Eleanor of Viseu.
Manuel III of Kongo
Manuel III Afonso of Kongo, born Kiditu, was the last Mwenekongo (titular ruler) of the Kingdom of Kongo, ruling as a vassal of the Portuguese empire from 1911 to 1914. His reign over the reduced territory of the kingdom ended following a 1914 revolt, at which point the Portuguese abolished the kingdom and assimilated the territory into the colony of Angola. Manuel III subsequently lost his title by 1915, when the royal family handed the title to Álvaro XV Afonso Nzinga.