Inertia
Albert Einstein's theory of special relativity, as proposed in his 1905 paper entitled "On the Electrodynamics of Moving Bodies" was built on the understanding of inertia and inertial reference frames developed by Galileo and Newton. While this revolutionary theory did significantly change the meaning of many Newtonian concepts such as mass, energy, and distance, Einstein's concept of inertia remained unchanged from Newton's original meaning (in fact, the entire theory was based on Newton's definition of inertia). However, this resulted in a limitation inherent in special relativity: the principle of relativity could only apply to reference frames that were "inertial" in nature (meaning when no acceleration was present). In an attempt to address this limitation, Einstein proceeded to develop his general theory of relativity ("The Foundation of the General Theory of Relativity," 1916), which ultimately provided a unified theory for both "inertial" and "noninertial" (accelerated) reference frames. However, in order to accomplish this, in general relativity, Einstein found it necessary to redefine several fundamental concepts (such as gravity) in terms of a new concept of "curvature" of space-time, instead of the more traditional system of forces understood by Newton.
Spacetime
In 1905, Einstein introduced special relativity (even though without using the techniques of the spacetime formalism) in its modern understanding as a theory of space and time. While his results are mathematically equivalent to those of Lorentz and Poincaré, it was Einstein who showed that the Lorentz transformations are not the result of interactions between matter and aether, but rather concern the nature of space and time itself. He obtained all of his results by recognizing that the entire theory can be built upon two postulates: The principle of relativity and the principle of the constancy of light speed.