Yuma War
The Yuma War was the name given to a series of United States military operations conducted in southern California and what is today southwestern Arizona from 1850 to 1853. The Yumans were the primary opponent of the United States Army, though engagements were fought between the Americans and other native groups in the region. Conflict generally took the form of guerrilla warfare, and, over the course of three years, the army engaged in pursuing unfriendly natives, protecting American settlers crossing the Colorado River and preventing conflict between the native tribes. A peace treaty in summer of 1853 was signed, ending hostilities between the Yuma and the United States, but it sparked a short war between the Yuma and the Cocopah. During the conflict, the historic Fort Yuma was constructed and became an important outpost on the frontier.
Fort King George
The Yamasee War of 1715–1717 broke out. This war started because of grave injustices carried out by Carolina traders against their Native American clients. For many years the traders had been systematically cheating the Indians in the fur trade by using bogus weights and measures, applying tough credit standards, severely indebting Native American suppliers, and taking Indian slaves for unpaid debts. Finally, the Yamasee turned on South Carolina and nearly destroyed the colony. Virginia's support and Cherokee warriors helped deflect the Yamasee attacks. 
After the surviving Yamasee were expelled, they migrated to the St. Augustine area and cultivated a new alliance with the Spanish. South Carolina was left weak and vulnerable with no military buffer along its southern fringes, and the war alienated the Creek tribes to the west.