Blood
About 98.5% of the oxygen in a sample of arterial blood in a healthy human breathing air at sea-level pressure is chemically combined with the hemoglobin. About 1.5% is physically dissolved in the other blood liquids and not connected to hemoglobin. The hemoglobin molecule is the primary transporter of oxygen in mammals and many other species (for exceptions, see below). Hemoglobin has an oxygen binding capacity between 1.36 and 1.40 ml O per gram hemoglobin, which increases the total blood oxygen capacity seventyfold, compared to if oxygen solely were carried by its solubility of 0.03 ml O per liter blood per mm Hg partial pressure of oxygen (about 100 mm Hg in arteries).
Mount Everest
In May 2007, the Caudwell Xtreme Everest undertook a medical study of oxygen levels in human blood at extreme altitude. Over 200 volunteers climbed to Everest Base Camp where various medical tests were performed to examine blood oxygen levels. A small team also performed tests on the way to the summit. Even at base camp, the low partial pressure of oxygen had direct effect on blood oxygen saturation levels. At sea level, blood oxygen saturation is generally 98–99%. At base camp, blood saturation fell to between 85 and 87%. Blood samples taken at the summit indicated very low oxygen levels in the blood. A side effect of low blood oxygen is a greatly increased breathing rate, often 80–90 breaths per minute as opposed to a more typical 20–30. Exhaustion can occur merely attempting to breathe.