Manuel I of Portugal
Manuel's mother was the granddaughter of King John I of Portugal, whereas his father was the second surviving son of King Edward of Portugal and the younger brother of King Afonso V of Portugal. In 1495, Manuel succeeded his first cousin, King John II of Portugal, who was also his brother-in-law, as husband to Manuel's sister, Eleanor of Viseu.
Maria I of Portugal
In 1815 the government of the Prince Regent João elevated Brazil to the status of a kingdom, and Maria I was proclaimed the Queen of the United Kingdom of Portugal, Brazil and the Algarves. When Napoleon was finally defeated in 1815, Maria and her family remained in Brazil.