Glutamate (neurotransmitter)
Glutamate is a major constituent of a wide variety of proteins; consequently it is one of the most abundant amino acids in the human body. Under ordinary conditions enough is obtained from the diet that there is no need for any to be synthesized. Nevertheless, glutamate is formally classified as a non-essential amino acid, because it can be synthesized from alpha-Ketoglutaric acid, which is produced as part of the citric acid cycle by a series of reactions whose starting point is citrate. Glutamate cannot cross the blood-brain barrier unassisted, but it is actively transported into the nervous system by a high affinity transport system, which maintains its concentration in brain fluids at a fairly constant level.
FAM149A
As stated above, FAM149A is made up of 482 amino acids. The most common amino acid is serine which makes up 9.8% of the gene. The least common amino acids are tryptophan and cysteine which each make up only 1.2% of the gene. The only recurring combination of amino acids in the protein is SLAS which occurs from amino acids 234-237 and from 324-327. In addition, the Isoelectric Point of FAM149A is 9.891999