Florida
Florida had become a burden to Spain, which could not afford to send settlers or garrisons. Madrid therefore decided to cede the territory to the United States through the Adams–Onís Treaty, which took effect in 1821. President James Monroe was authorized on March 3, 1821 to take possession of East Florida and West Florida for the United States and provide for initial governance. Andrew Jackson, on behalf of the U.S. federal government, served as a military commissioner with the powers of governor of the newly acquired territory for a brief period. On March 30, 1822, the U.S. Congress merged East Florida and part of West Florida into the Florida Territory.
By the early 1800s, Indian removal was a significant issue throughout the southeastern U.S. and also in Florida. In 1830, the U.S. Congress passed the Indian Removal Act and as settlement increased, pressure grew on the U.S. government to remove the Indians from Florida. Seminoles offered sanctuary to blacks, and these became known as the Black Seminoles, and clashes between whites and Indians grew with the influx of new settlers. In 1832, the Treaty of Payne's Landing promised to the Seminoles lands west of the Mississippi River if they agreed to leave Florida. Many Seminole left at this time.
Everglades
In 1817, Andrew Jackson invaded Florida to hasten its annexation to the United States, in what became known as the First Seminole War. After Florida became a U.S. territory in 1821, conflicts between settlers and the Seminole increased as the former tried to acquire lands. The Second Seminole War lasted from 1835 to 1842, and afterward, the US forcibly removed about 3,000 Seminole and 800 Black Seminole to Indian Territory (now Oklahoma), west of the Mississippi River. Many others died in the war. Conflict broke out again in the Third Seminole War from 1855 to 1859, when a few hundred Seminole fought off US forces from the swamps of the Everglades. The US finally decided to leave them alone, as they could not dislodge them even after this protracted and expensive warfare.