Manuel I of Portugal
Manuel's mother was the granddaughter of King John I of Portugal, whereas his father was the second surviving son of King Edward of Portugal and the younger brother of King Afonso V of Portugal. In 1495, Manuel succeeded his first cousin, King John II of Portugal, who was also his brother-in-law, as husband to Manuel's sister, Eleanor of Viseu.
Descendants of Manuel I of Portugal
John II died on 25 October 1495 and Manuel became monarch of Portugal. During his reign, Manuel expanded the Portuguese Empire, making it the most formidable power in all of Europe at the time.