When did the Human Genome Project begin?
GENCODE
The Human Genome Project was an international research effort to determine the sequence of the human genome and identify the genes that it contains. The Project was coordinated by the National Institutes of Health and the U.S. Department of Energy. Additional contributors included universities across the United States and international partners in the United Kingdom, France, Germany, Japan, and China. The Human Genome Project formally began in 1990 and was completed in 2003, 2 years ahead of its original schedule.
Following the release of the completed human genome sequence in April 2003, the scientific community intensified its efforts to mine the data for clues about how the body works in health and in disease. A basic requirement for this understanding of human biology is the ability to identify and characterize sequence-based functional elements through experimentation and computational analysis. In September 2003, the NHGRI introduced the ENCODE project to facilitate the identification and analysis of the complete set of functional elements in the human genome sequence.
Neanderthal genome project
It was initiated by 454 Life Sciences, a biotechnology company based in Branford, Connecticut in the United States and is coordinated by the Max Planck Institute for Evolutionary Anthropology in Germany. In May 2010 the project published their initial draft of the Neanderthal genome based on the analysis of four billion base remain in modern humans outside Africa.
Genome diversity and karyotype evolution of mammals
The first step of the Human Genome Project took place when Tjio and Levan, in 1956, reported the accurate diploid number of human chromosomes as 2n = 46.
Human Variome Project
Geneticists, Diagnosticians, Researchers and Bio-informatics scientists came together in June 2006 at the Human Variome Project Meeting, organized by Professor Cotton’s team, and agreed take on the task of organising data collection and unifying the systems of data access and storage. This initiative builds on substantial pilot work and achievements of the Human Genome Variation Society. The authority of those initiating this project is evidenced by the fact that major international bodies were present. These included WHO, OECD, European Commission, UNESCO, March of Dimes (US), Centers for Disease Control and Prevention (US), Google, representatives of two dozen international genetics bodies, numerous genetics journals, 20 countries and Australian State and Federal Governments.
Human Genome Project
In 1990, the two major funding agencies, DOE and NIH, developed a memorandum of understanding in order to coordinate plans and set the clock for the initiation of the Project to 1990. At that time, David Galas was Director of the renamed “Office of Biological and Environmental Research” in the U.S. Department of Energy's Office of Science and James Watson headed the NIH Genome Program. In 1993, Aristides Patrinos succeeded Galas and Francis Collins succeeded James Watson, assuming the role of overall Project Head as Director of the U.S. National Institutes of Health (NIH) National Center for Human Genome Research (which would later become the National Human Genome Research Institute). A working draft of the genome was announced in 2000 and the papers describing it were published in February 2001. A more complete draft was published in 2003, and genome "finishing" work continued for more than a decade.
ENCODE
The ENCODE pilot project process involved close interactions between computational and experimental scientists to evaluate a number of methods for annotating the human genome. A set of regions representing approximately 1% (30 Mb) of the human genome was selected as the target for the pilot project and was analyzed by all ENCODE pilot project investigators. All data generated by ENCODE participants on these regions was rapidly released into public databases.
Human Genome Project
The fact that the Santa Fe workshop was motivated and supported by a Federal Agency opened a path, albeit a difficult and tortuous one, for converting the idea into a public policy in the United States. In a memo to the Assistant Secretary for Energy Research (Alvin Trivelpiece), Charles DeLisi, who was then Director of the OHER, outlined a broad plan for the project. This started a long and complex chain of events which led to approved reprogramming of funds that enabled the OHER to launch the Project in 1986, and to recommend the first line item for the HGP, which was in President Reagan's 1988 budget submission, and ultimately approved by the Congress. Of particular importance in Congressional approval was the advocacy of Senator Peter Domenici, whom DeLisi had befriended. Domenici chaired the Senate Committee on Energy and Natural Resources, as well as the Budget Committee, both of which were key in the DOE budget process. Congress added a comparable amount to the NIH budget, thereby beginning official funding by both agencies.
GWAS Central
The Human Genome Bi-Allelic SEquence (HGBASE) database was the first version of what is now GWAS Central. It was first released in August 1998, focusing on providing a centralized collection of known human single nucleotide polymorphisms and other simple DNA variants. It was the first publicly available SNP database. The project was expanded over the next year by a consortium including the Karolinska Institute, the European Bioinformatics Institute and the European Molecular Biology Laboratory. Corporate support was provided by Pfizer and GlaxoSmithKline. The version released in November 2001 was renamed the Human Genome Variation database (HGVbase), as this was a better reflection of the scope of the database and its emphasis on collection from many different laboratories. In addition this also highlighted its new role as a central repository for data collection efforts in collaboration with the Human Genome Variation Society.
Cognitive genomics
Chimpanzees ("Pan troglodytes") are the closest genetic relatives to human, sharing 93.6% genetic similarity. It is believed that humans and chimpanzees shared a common genetic ancestor around 7 million years ago. The movement to sequence the chimpanzee genome began in 1998 and was given high priority by the US National Institutes of Health (NIH).
Human Genome Project
In 1998, a similar, privately funded quest was launched by the American researcher Craig Venter, and his firm Celera Genomics. Venter was a scientist at the NIH during the early 1990s when the project was initiated. The $300,000,000 Celera effort was intended to proceed at a faster pace and at a fraction of the cost of the roughly $3 billion publicly funded project. The Celera approach was able to proceed at a much more rapid rate, and at a lower cost than the public project because it relied upon data made available by the publicly funded project.
McDonnell Genome Institute
Founded in 1993, the McDonnell Genome Institute, formerly the Genome Sequencing Center and The Genome Institute, began as a key player in the Human Genome Project, ultimately contributing more than 25 percent of the finished sequence. Following completion of the working draft of the human genome in 2000, and the finished human genome sequence in 2003, McDonnell Genome Institute turned its sequencing and analysis skills to determining the genomes of many other organisms in order to provide the first reference sequences for these species. In 2014, civic leaders and longtime philanthropists Elizabeth H. and James S. McDonnell III pledged $25 million to The Genome Institute, which was renamed the Elizabeth H. and James S. McDonnell III Genome Institute at Washington University.McDonnell Genome Institute employs over 300 full-time faculty and staff from a variety of disciplines. Core staff include:
Human genetic variation
Human genome projects are scientific endeavors that determine or study the structure of the human genome. The Human Genome Project was a landmark genome project.Regional:
Projects:
Manx cat
To better understand the genetics of the breed, the Manx Cat Genome Project (MCGP) was launched in August 2015, as a crowdfunded volunteer project by computational biologist Rachel Glover of Douglas, Isle of Man, to perform the first whole genome sequencing of the Manx cat, uncovering the genetic mutations that make the Manx distinct from other cat populations, and to contribute data to the genome databases at the 99 Lives Cat Genome Sequencing Project of the University of Missouri, and the US National Center for Biotechnology Information (NCBI). It is the Isle of Man's first gene sequencing programme, with samples collected and data analysed by MCGP in the Isle of Man, with the input of scientists around the world, initial sequencing work being performed by the firm Edinburgh Genomics and the University of Edinburgh in Scotland and by 99 Lives, and server resources donated by Isle of Man biomedical information technology company ServiceTech.
Beijing Genomics Institute
Wang Jian, Yu Jun, Yang Huanming and Liu Siqi created BGI in November 1999, in Beijing, China as a non-governmental independent research institute in order to participate in the Human Genome Project as China's representative. After the project was completed, funding dried up. So BGI moved to Hangzhou in exchange for funding from the Hangzhou Municipal Government. In 2002, BGI sequenced the rice genome which was a cover story in the journal Science. In 2003 BGI decoded the SARS virus genome and created a kit for detection of the virus. In 2003, BGI Hangzhou and the Zhejiang University founded a new research institute, the James D. Watson Institute of Genome Sciences, Zhejiang University. The Watson Institute was intended to become a major center for research and education in East Asia modeled after the Cold Spring Harbor Laboratory in the US.
Human Genome Project
At the onset of the Human Genome Project several ethical, legal, and social concerns were raised in regards to how increased knowledge of the human genome could be used to discriminate against people. One of the main concerns of most individuals was the fear that both employers and health insurance companies would refuse to hire individuals or refuse to provide insurance to people because of a health concern indicated by someone's genes. In 1996 the United States passed the Health Insurance Portability and Accountability Act (HIPAA) which protects against the unauthorized and non-consensual release of individually identifiable health information to any entity not actively engaged in the provision of healthcare services to a patient. Other nations passed no such protections.
Thomas J. Hudson
There he became involved with Eric Lander's projects and eventually led the effort to build a physical map of the human genome, which was an important step towards the generation of the complete sequence of the human genome. He supervised a large team of engineers, biologists, computer scientists to build high throughput PCR systems. The robot built by his team, called the "Genomatron", performed up to 300,000 PCR reactions per day. He was also part of an international effort to build a transcript map of the human genome. By 1996, his team had mapped more than 10,000 genes. In 1995, he became the assistant director of the Whitehead Institute/MIT Center for Genome Research a position which he held until 2001.
Human Genome Organisation
The Human Genome Organisation (HUGO) is an organization involved in the Human Genome Project, a project about mapping the human genome. HUGO was established in 1989 as an international organization, primarily to foster collaboration between genome scientists around the world. The HUGO Gene Nomenclature Committee (HGNC), sometimes referred to as "HUGO", is one of HUGO's most active committees and aims to assign a unique gene name and symbol to each human gene.
Office of Science
The Office of Biological and Environmental Research (BER) supports research and scientific user facilities in the biological and environmental sciences to support DOE's missions in energy, environment, and basic research. BER initiated the Human Genome Project in 1986 and has continued to support activity in genomics-based systems biology and initiatives related to biotechnology applications. The Joint Genome Institute, formed in 1997, initially conducted sequencing of human DNA in support of the Human Genome Project. Its current focus is on sequencing the genomes of microbes, microbial communities, fungi, plants, and other organisms.
Horse genome
The horse genome was first sequenced in 2006. The Horse Genome Project mapped 2.7 billion DNA base pairs, and released the full map in 2009. The horse genome is larger than the dog genome, but smaller than the human genome or the bovine genome. It encompasses 31 autosomes and two sex chromosomes.
DNA sequencing
Sanger sequencing is the method which prevailed from the 1980s until the mid-2000s. Over that period, great advances were made in the technique, such as fluorescent labelling, capillary electrophoresis, and general automation. These developments allowed much more efficient sequencing, leading to lower costs. The Sanger method, in mass production form, is the technology which produced the first human genome in 2001, ushering in the age of genomics. However, later in the decade, radically different approaches reached the market, bringing the cost per genome down from $100 million in 2001 to $10,000 in 2011.
Logology (science of science)
What has been dubbed "Big Science" emerged from the United States' World War II Manhattan Project that produced the world's first nuclear weapons; and Big Science has since been associated with physics, which requires massive particle accelerators. In biology, Big Science debuted in 1990 with the Human Genome Project to sequence human DNA. In 2013 neuroscience became a Big Science domain when the U.S. announced a BRAIN Initiative and the European Union announced a Human Brain Project. Major new brain-research initiatives were also announced by Israel, Canada, Australia, New Zealand, Japan, and China.
1000 Plant Genomes Project
Announced in 2008, shortly after the human 1000 Genomes Project, the 1000 Plant Genomes Project (1KP) is a similar large-scale genomics using the high speed and efficiency of next-generation DNA sequencing. Headed by Dr. Gane Ka-Shu Wong and Dr. Michael Deyholos of the University of Alberta, the project successfully sequenced the transcriptomes (expressed genes) of 1000 different plant species by 2014.
Broad Institute
The Broad Institute evolved from a decade of research collaborations among MIT and Harvard scientists. One cornerstone was the Center for Genome Research of Whitehead Institute at MIT. Founded in 1982, the Whitehead became a major center for genomics and the Human Genome Project. As early as 1995, scientists at the Whitehead started pilot projects in genomic medicine, forming an unofficial collaborative network among young scientists interested in genomic approaches to cancer and human genetics. Another cornerstone was the Institute of Chemistry and Cell Biology established by Harvard Medical School in 1998 to pursue chemical genetics as an academic discipline. Its screening facility was one of the first high-throughput resources opened in an academic setting. It facilitated small molecule screening projects for more than 80 research groups worldwide.
Human genome
In June 2016, scientists formally announced HGP-Write, a plan to synthesize the human genome.
Human genome
Regulatory sequences have been known since the late 1960s. The first identification of regulatory sequences in the human genome relied on recombinant DNA technology. Later with the advent of genomic sequencing, the identification of these sequences could be inferred by evolutionary conservation. The evolutionary branch between the primates and mouse, for example, occurred 70–90 million years ago. So computer comparisons of gene sequences that identify conserved non-coding sequences will be an indication of their importance in duties such as gene regulation.
Genomics
The advent of these technologies resulted in a rapid intensification in the scope and speed of completion of genome sequencing projects. The first complete genome sequence of a eukaryotic organelle, the human mitochondrion (16,568 bp, about 16.6 kb [kilobase]), was reported in 1981, and the first chloroplast genomes followed in 1986. In 1992, the first eukaryotic chromosome, chromosome III of brewer's yeast "Saccharomyces cerevisiae" (315 kb) was sequenced. The first free-living organism to be sequenced was that of "Haemophilus influenzae" (1.8 Mb [megabase]) in 1995. The following year a consortium of researchers from laboratories across North America, Europe, and Japan announced the completion of the first complete genome sequence of a eukaryote, "S. cerevisiae" (12.1 Mb), and since then genomes have continued being sequenced at an exponentially growing pace. , the complete sequences are available for: 2,719 viruses, 1,115 archaea and bacteria, and 36 eukaryotes, of which about half are fungi.
Bermuda Principles
The Bermuda Principles set out rules for the rapid and public release of DNA sequence data. The Human Genome Project, a multinational effort to sequence the human genome, generated vast quantities of data about the genetic make-up of humans and other organisms. But, in some respects, even more remarkable than the impressive quantity of data generated by the Human Genome Project is the speed at which that data has been released to the public. At a 1996 summit in Bermuda, leaders of the scientific community agreed on a groundbreaking set of principles requiring that all DNA sequence data be released in publicly accessible databases within twenty-four hours after generation. These "Bermuda Principles" (also known as the "Bermuda Accord") contravened the typical practice in the sciences of making experimental data available only after publication. These principles represent a significant achievement of private ordering in shaping the practices of an entire industry and have established rapid pre-publication data release as the norm in genomics and other fields.
ENCODE
Encode was launched by the US National Human Genome Research Institute (NHGRI) in September 2003. Intended as a follow-up to the Human Genome Project, the ENCODE project aims to identify all functional elements in the human genome.
Human Genome Sciences
Human Genome Sciences was a biopharmaceutical corporation founded in 1992 by Craig Venter, Alan Walton and Wally Sternberg. It uses the human DNA sequence to develop protein and antibody drugs. It had drugs under development to treat such diseases as hepatitis C, systemic lupus erythmatosis, anthrax disease, and cancer. It collaborated with other biotechnology and pharmaceutical companies, for development partnerships and licensing.
Human Genome Project
Key findings of the draft (2001) and complete (2004) genome sequences include:The Human Genome Project was started in 1990 with the goal of sequencing and identifying all three billion chemical units in the human genetic instruction set, finding the genetic roots of disease and then developing treatments. It is considered a megaproject because the human genome has approximately 3.3 billion base pairs. With the sequence in hand, the next step was to identify the genetic variants that increase the risk for common diseases like cancer and diabetes.
World Community Grid
The Genome Comparison project is sponsored by the Brazilian research institution Fiocruz. The project was launched on November 21, 2006, and completed on July 21, 2007. The project seeks to compare gene sequences of different organisms against each other in order to find similarities between them. Scientists hope to discover what purpose a particular gene sequence serves in a particular function of one organism, via comparing it to a similar gene sequence of known function in another organism.
Genome Project-Write
The Genome Project - Write (also known as GP-Write) includes sub-projects like Human Genome Project-Write (HGP-Write), formally announced on 2 Jun 2016, is an extension of Genome Projects (aimed at reading genomes since 1984), now to include development of technologies for synthesis and testing of many genomes of microbes, plants and animals. This leverages two decades of work on Synthetic Biology and Artificial gene synthesis.
UK Biobank
The Estonian Genome Project was started in 2000 with the aim of improving public health in the country. Initially it was hoped to obtain biological samples and health data from 70% of the 1.4 million population of Estonia. The project ran into financial difficulties and, as of December 2013, the project had data from 52,000 adult gene donors and the aim had been adjusted downwards to collect genealogical, genome and health data from 5% of the population.
Genomics
A rough draft of the human genome was completed by the Human Genome Project in early 2001, creating much fanfare. This project, completed in 2003, sequenced the entire genome for one specific person, and by 2007 this sequence was declared "finished" (less than one error in 20,000 bases and all chromosomes assembled). In the years since then, the genomes of many other individuals have been sequenced, partly under the auspices of the 1000 Genomes Project, which announced the sequencing of 1,092 genomes in October 2012. Completion of this project was made possible by the development of dramatically more efficient sequencing technologies and required the commitment of significant bioinformatics resources from a large international collaboration. The continued analysis of human genomic data has profound political and social repercussions for human societies.
R. Ellen Magenis
Magenis's first major research project involved a heritable fragile site on the long (q) arm of chromosome 16. She traced this 16q fragile site through a multigenerational family and, together with Hecht and Everett Lovrien, she linked the 16q fragile site to the gene for haptoglobin. The mapping of haptoglobin to 16q was the second instance in which a human gene was mapped to a specific autosome (non-sex chromosome), presaging the Human Genome Project.
German Resource Center for Genome Research
In the summer of 1995, the Resource Centre was established as part of the German Human Genome Project (DHGP) by Hans Lehrach (Max Planck Institute for Molecular Genetics (MPIMG), Berlin-Dahlem), Günther Zehetner (MPIMG, until July 2000 Scientific Director of the Berlin Resource Center) and Annemarie Poustka (German Cancer Research Center (DKFZ), Heidelberg). As "Resource Center/Primary Database" (RZPD) it took over the work of the RLDB. It was funded by the Federal Ministry of Education and Research (BMBF) in order to provide the materials free of charge to the members of the DHGP, while they were available to other researchers at cost prize. The RZPD became the largest database for genetic clones worldwide and was associated with many of the major national and international gene and genome research projects.
Human Microbiome Project
The Human Microbiome Project (HMP) was a United States National Institutes of Health (NIH) research initiative to improve understanding of the microbial flora involved in human health and disease. Launched in 2007, the first phase (HMP1) focused on identifying and characterizing human microbial flora. The second phase, known as the Integrative Human Microbiome Project (iHMP) launched in 2014 with the aim of generating resources to characterize the microbiome and elucidating the roles of microbes in health and disease states. The program received $170 million in funding by the NIH Common Fund from 2007 to 2016.
Human
One human genome was sequenced in full in 2003, and currently efforts are being made to achieve a sample of the genetic diversity of the species (see International HapMap Project). By present estimates, humans have approximately 22,000 genes. The variation in human DNA is very small compared to other species, possibly suggesting a population bottleneck during the Late Pleistocene (around 100,000 years ago), in which the human population was reduced to a small number of breeding pairs. Nucleotide diversity is based on single mutations called single nucleotide polymorphisms (SNPs). The nucleotide diversity between humans is about 0.1%, i.e. 1 difference per 1,000 base pairs. A difference of 1 in 1,000 nucleotides between two humans chosen at random amounts to about 3 million nucleotide differences, since the human genome has about 3 billion nucleotides. Most of these single nucleotide polymorphisms (SNPs) are neutral but some (about 3 to 5%) are functional and influence phenotypic differences between humans through alleles.
National Institutes of Health
By the 1990s, the NIH committee focus had shifted to DNA research, and launched the Human Genome Project.Intramural research is primarily conducted at the main campus in Bethesda, Maryland and Rockville, Maryland, and the surrounding communities.
UCSC Genome Browser
Initially built and still managed by Jim Kent, then a graduate student, and David Haussler, professor of Computer Science (now Biomolecular Engineering) at the University of California, Santa Cruz in 2000, the UCSC Genome Browser began as a resource for the distribution of the initial fruits of the Human Genome Project. Funded by the Howard Hughes Medical Institute and the National Human Genome Research Institute, NHGRI (one of the US National Institutes of Health), the browser offered a graphical display of the first full-chromosome draft assembly of human genome sequence. Today the browser is used by geneticists, molecular biologists and physicians as well as students and teachers of evolution for access to genomic information.
Chimpanzee genome project
The Chimpanzee Genome Project is an effort to determine the DNA sequence of the Chimpanzee genome. It is expected that by comparing the genomes of humans and other apes, it will be possible to better understand what makes humans distinct from other species from a genetic perspective. It will also aid in the study of diseases that affect (or, conversely, do not affect) various primate species.
Personal Genetics Education Project
The Personal Genetics Education Project (pgEd) aims to engage and inform a worldwide audience about the benefits of knowing one's genome as well as the ethical, legal and social issues (ELSI) and dimensions of personal genetics. pgEd was founded in 2006, is housed in the Department of Genetics at Harvard Medical School and is directed by Ting Wu, a professor in that department. It employs a variety of strategies for reaching general audiences, including generating online curricular materials, leading discussions in classrooms, workshops, and conferences, developing a mobile educational game (Map-Ed), holding an annual conference geared toward accelerating awareness (GETed), and working with the world of entertainment to improve accuracy and outreach.
Human Genome Project
The Human Genome Project (HGP) was declared complete in April 2003. An initial rough draft of the human genome was available in June 2000 and by February 2001 a working draft had been completed and published followed by the final sequencing mapping of the human genome on April 14, 2003. Although this was reported to cover 99% of the euchromatic human genome with 99.99% accuracy, a major quality assessment of the human genome sequence was published on May 27, 2004 indicating over 92% of sampling exceeded 99.99% accuracy which was within the intended goal. Further analyses and papers on the HGP continue to occur.
Applied Biosystems
Also in 1990, the U.S. government approved financing to support the Human Genome Project. Dr. James D. Watson, who founded the consortium, forecast that the project could be completed in 15 years from its 1990 starting date, at a cost of cost US$3 billion. Over the next couple years, Japan began a project to sequence the rice genome, and other laboratories initiated programs to sequence the mouse, fruit fly, and yeast genomes.
Ensembl genome database project
Ensembl genome database project is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent completion of the Human Genome Project. Ensembl aims to provide a centralized resource for geneticists, molecular biologists and other researchers studying the genomes of our own species and other vertebrates and model organisms. Ensembl is one of several well known genome browsers for the retrieval of genomic information.
HumGen
The Project was launched to respond to the urgent need for informed public policy, with the goal of analyzing international, regional, and national trends in the context of socio-ethical issues in human genetics research.
Human Genome Project
Due to widespread international cooperation and advances in the field of genomics (especially in sequence analysis), as well as major advances in computing technology, a 'rough draft' of the genome was finished in 2000 (announced jointly by U.S. President Bill Clinton and the British Prime Minister Tony Blair on June 26, 2000). This first available rough draft assembly of the genome was completed by the Genome Bioinformatics Group at the University of California, Santa Cruz, primarily led by then graduate student Jim Kent. Ongoing sequencing led to the announcement of the essentially complete genome on April 14, 2003, two years earlier than planned. In May 2006, another milestone was passed on the way to completion of the project, when the sequence of the last chromosome was published in "Nature".
Human Genome Structural Variation
The 1000 genomes project was able to successfully produce the DNA sequence of the human genome. They provided much sequencing data from many populations to analyze as well as a reference human genome for comparison and future studies. One study took advantage of this resource to question the structural variation differences between genomes from whole genome sequence data. It was known that human diseases are affected by duplications and deletions and that copy number analysis is common but multiallelic copy number variants (mCNVs) were not as well studied. The researchers got their data from the 1000 genomes project and analyzed 849 different genomes from a variety of populations that were sequenced in order to find large mCNVs. From their analysis, they found that mCNVs create most genetic variation in gene dosage compared to other structural variants and that the gene expression variation is created by the dosage diversity of genes created by mCNVs. The study underlined the great significance that structural variants, especially mCNVs, have on gene dosage which leads to variable gene expressions and human phenotypic diversity in the population.
Bernadine Healy
Healy was director of the Research Institute at the Cleveland Clinic Foundation when President George H. W. Bush tapped her in 1991 to become director of the NIH, its first woman head. She took on many initiatives during her two years at the helm, including the development of a major intramural laboratory for human genomics and recruited a world-renowned team to head the Human Genome Project, including current NIH director Dr. Francis Collins, elevated nursing research to an independent NIH institute, established a policy whereby the NIH would fund only those clinical trials that included both men and women when the condition being studied affects both sexes.
List of drugs by year of discovery
21st century begins with the first complete sequences of individual human genomes by Human Genome Project, on February 12, 2001, this allowed a switch in drug development and research from the traditional way of drug discovery that was isolating molecules from plants or animals or create new molecules and see if they could be useful in treatment of illness in humans, to pharmacogenomics, that is the study and knowledge of how genes respond to drugs. Another field beneficed by Human Genome Project is pharmacogenetics, that is the study of inherited genetic differences in drug metabolic pathways which can affect individual responses to drugs, both in terms of therapeutic effect as well as adverse effects.
Human Genome Diversity Project
A number of the principal collaborators in the HGDP have been involved in the privately funded Genographic Project launched in April 2005 with similar aims.
Human Genome Project
Alvin Trivelpiece sought and obtained the approval of DeLisi's proposal by Deputy Secretary William Flynn Martin. This chart was used in the spring of 1986 by Trivelpiece, then Director of the Office of Energy Research in the Department of Energy, to brief Martin and Under Secretary Joseph Salgado regarding his intention to reprogram $4 million to initiate the project with the approval of Secretary Herrington. This reprogramming was followed by a line item budget of $16 million in the Reagan Administration’s 1987 budget submission to Congress. It subsequently passed both Houses. The Project was planned for 15 years.
GDB Human Genome Database
In 1989 the Howard Hughes Medical Institute provided funding to establish a central repository for human genetic mapping data. This project ultimately resulted in the creation of the GDB Human Genome DataBase in 1990. It was a key database in the Human Genome Project.
Beijing Institute of Genomics
Its predecessor was Human Genome Research Center of Institute of Genetics and Developmental Biology (CAS) which was founded on August 1998. The predecessor center participated in the International Human Genome Project (HGP) on behalf of China, and China became the sixth member states which took part in the Human Genome Project.
Charles DeLisi
In addition to the medical and scientific advances engendered by the Human Genome Project, it and its progeny have had a profound effect on the sociology and culture of cell biology. The computer science community, in particular, moved with extraordinary dexterity into cell biology, transforming the field and creating a record of discovery destined to provide material for a remarkable story in the sociology of late 20th and early 21st Century science. Computational and mathematical methods are now widely viewed as central to progress in cell biology, a change that is forcing even the most conservative universities to respond to a new paradigm in biological education. The Human Genome Project enabled a rapid and smooth transformation of all aspects of DOE’s health and environmental and energy programs, propelling the Office of Health and Environmental Research to a position of international importance.
Human Genome Project
Celera initially announced that it would seek patent protection on "only 200–300" genes, but later amended this to seeking "intellectual property protection" on "fully-characterized important structures" amounting to 100–300 targets. The firm eventually filed preliminary ("place-holder") patent applications on 6,500 whole or partial genes.
Celera also promised to publish their findings in accordance with the terms of the 1996 "Bermuda Statement", by releasing new data annually (the HGP released its new data daily), although, unlike the publicly funded project, they would not permit free redistribution or scientific use of the data. The publicly funded competitors were compelled to release the first draft of the human genome before Celera for this reason. On July 7, 2000, the UCSC Genome Bioinformatics Group released a first working draft on the web. The scientific community downloaded about 500 GB of information from the UCSC genome server in the first 24 hours of free and unrestricted access.
Biology
The discovery of the physical representation of heredity came along with evolutionary principles and population genetics. In the 1940s and early 1950s, experiments pointed to DNA as the component of chromosomes that held the trait-carrying units that had become known as genes. A focus on new kinds of model organisms such as viruses and bacteria, along with the discovery of the double helical structure of DNA in 1953, marked the transition to the era of molecular genetics. From the 1950s to present times, biology has been vastly extended in the molecular domain. The genetic code was cracked by Har Gobind Khorana, Robert W. Holley and Marshall Warren Nirenberg after DNA was understood to contain codons. Finally, the Human Genome Project was launched in 1990 with the goal of mapping the general human genome. This project was essentially completed in 2003, with further analysis still being published. The Human Genome Project was the first step in a globalized effort to incorporate accumulated knowledge of biology into a functional, molecular definition of the human body and the bodies of other organisms.
Human genome
The Human Genome Project produced the first complete sequences of individual human genomes, with the first draft sequence and initial analysis being published on February 12, 2001 simultaneously with Celera Corporation. The human genome was the first of all vertebrates to be completely sequenced. As of 2012, thousands of human genomes have been completely sequenced, and many more have been mapped at lower levels of resolution. The resulting data are used worldwide in biomedical science, anthropology, forensics and other branches of science. There is a widely held expectation that genomic studies will lead to advances in the diagnosis and treatment of diseases, and to new insights in many fields of biology, including human evolution.
Whole genome sequencing
The first nearly complete human genomes sequenced were two Americans of predominantly Northwestern European ancestry in 2007 (J. Craig Venter at 7.5-fold coverage, and James Watson at 7.4-fold). This was followed in 2008 by sequencing of an anonymous Han Chinese man (at 36-fold), a Yoruban man from Nigeria (at 30-fold), and a female caucasian Leukemia patient (at 33 and 14-fold coverage for tumor and normal tissues). Steve Jobs was among the first 20 people to have their whole genome sequenced, reportedly for the cost of $100,000. , there were 69 nearly complete human genomes publicly available. In November 2013, a Spanish family made their personal genomics data publicly available under a Creative Commons public domain license. The work was led by Manuel Corpas and the data obtained by direct-to-consumer genetic testing with 23andMe and the Beijing Genomics Institute). This is believed to be the first such public genomics dataset for a whole family.
1000 Genomes Project
The 1000 Genomes Project (abbreviated as 1KGP), launched in January 2008, was an international research effort to establish by far the most detailed catalogue of human genetic variation. Scientists planned to sequence the genomes of at least one thousand anonymous participants from a number of different ethnic groups within the following three years, using newly developed technologies which were faster and less expensive. In 2010, the project finished its pilot phase, which was described in detail in a publication in the journal "Nature". In 2012, the sequencing of 1092 genomes was announced in a "Nature" publication. In 2015, two papers in "Nature" reported results and the completion of the project and opportunities for future research. Many rare variations, restricted to closely related groups, were identified, and eight structural-variation classes were analyzed.
Science
The Human Genome Project was completed in 2003, determining the sequence of nucleotide base pairs that make up human DNA, and identifying and mapping all of the genes of the human genome. Induced pluripotent stem cells were developed in 2006, a technology allowing adult cells to be transformed into stem cells capable of giving rise to any cell type found in the body, potentially of huge importance to the field of regenerative medicine.
Human Genome Project
Along with identifying all of the approximately 20,000–25,000 genes in the human genome, the Human Genome Project also sought to address the ethical, legal, and social issues that were created by the onset of the project. For that the Ethical, Legal, and Social Implications (ELSI) program was founded in 1990. Five percent of the annual budget was allocated to address the ELSI arising from the project. This budget started at approximately $1.57 million in the year 1990, but increased to approximately $18 million in the year 2014.
Genetic genealogy
The original Genographic Project was a five-year research study launched in 2005 by the National Geographic Society and IBM, in partnership with the University of Arizona and Family Tree DNA. Its goals were primarily anthropological. The project announced that by April 2010 it had sold more than 350,000 of its public participation testing kits, which test the general public for either twelve STR markers on the Y-Chromosome or mutations on the HVR1 region of the mtDNA.
Human Genome Project
The $3-billion project was formally founded in 1990 by the US Department of Energy and the National Institutes of Health, and was expected to take 15 years. In addition to the United States, the international consortium comprised geneticists in the United Kingdom, France, Australia, China and myriad other spontaneous relationships. Considering the inflation, the project roughly costed $5 billion.
David Haussler
As a collaborator on the international Human Genome Project, his team posted the first publicly available computational assembly of the human genome sequence on the Internet on July 7, 2000. Following this, his team developed the UCSC Genome Browser, a web-based tool that is used extensively in biomedical research and serves as the platform for several large-scale genomics projects. These include NHGRI’s ENCODE project to use omics methods to explore the function of every base in the human genome (for which UCSC serves as the Data Coordination Center), NIH’s Mammalian Gene Collection, NHGRI’s 1000 genomes project to explore human genetic variation, and NCI’s Cancer Genome Atlas project to explore the genomic changes in cancer.
Genome project
The Human Genome Project was a landmark genome project that is already having a major impact on research across the life sciences, with potential for spurring numerous medical and commercial developments.
1000 Genomes Project
Since the completion of the Human Genome Project, advances in human population genetics and comparative genomics have made it possible to gain increasing insight into the nature of genetic diversity. However, we are just beginning to understand how processes like the random sampling of gametes, structural variations (insertions/deletions (indels), copy number variations (CNV), and retroelements), single-nucleotide polymorphisms (SNPs), and natural selection have shaped the level and pattern of variation within species and also between species.
Cognitive genomics
In 2003, the Human Genome Project produced the first complete human genome. Despite the project’s success, very little is known about cognitive gene expression. Prior to 2003, any evidence concerning human brain connectivity was based on post-mortem observations. Due to ethical concerns, no invasive in vivo genomics studies have been performed on live humans.
Earth BioGenome Project
The Earth BioGenome Project (EBP) is an initiative that aims to sequence and catalog the genomes of all of Earth's currently described eukaryotic species over a period of ten years. The initiative would produce an open DNA database of biological information that provides a platform for scientific research and supports environmental and conservation initiatives. A scientific paper presenting the vision for the project was published in "PNAS" in April 2018, and the project officially launched November 1, 2018.
Human Genome Project
In the Celera Genomics private-sector project, DNA from five different individuals were used for sequencing. The lead scientist of Celera Genomics at that time, Craig Venter, later acknowledged (in a public letter to the journal "Science") that his DNA was one of 21 samples in the pool, five of which were selected for use.
Alan Edward Guttmacher
In 1987, Guttmacher became director of the Vermont Regional Genetics Center at the University of Vermont College of Medicine where he launched a series of programs in public health genetics, as well as directing the Vermont Cancer Center's Familial Cancer Program, the Vermont Newborn Screening Program, Vermont's only pediatric intensive care unit and the United States' first statewide effort to involve the general public in discussion of the Human Genome Project's ethical, legal, and social implications, supported by the NIH. He also maintained a busy practice in clinical genetics, conducted research, and was a tenured associate professor of pediatrics and medicine at the University of Vermont.
Human Connectome Project
The Human Connectome Project (HCP) is a five-year project sponsored by sixteen components of the National Institutes of Health, split between two consortia of research institutions. The project was launched in July 2009 as the first of three Grand Challenges of the NIH's Blueprint for Neuroscience Research. On September 15, 2010, the NIH announced that it would award two grants: $30 million over five years to a consortium led by Washington University in Saint Louis and the University of Minnesota, with strong contributions from Oxford University (FMRIB) and $8.5 million over three years to a consortium led by Harvard University, Massachusetts General Hospital and the University of California Los Angeles.
Comparative genomics
Virtually started as soon as the whole genomes of two organisms became available (that is, the genomes of the bacteria "Haemophilus influenzae" and "Mycoplasma genitalium") in 1995, comparative genomics is now a standard component of the analysis of every new genome sequence. With the explosion in the number of genome projects due to the advancements in DNA sequencing technologies, particularly the next-generation sequencing methods in late 2000s, this field has become more sophisticated, making it possible to deal with many genomes in a single study. Comparative genomics has revealed high levels of similarity between closely related organisms, such as humans and chimpanzees, and, more surprisingly, similarity between seemingly distantly related organisms, such as humans and the yeast "Saccharomyces cerevisiae". It has also showed the extreme diversity of the gene
composition in different evolutionary lineages.
Chromosome 21
Researchers working on the Human Genome Project announced in May 2000 that they had determined the sequence of base pairs that make up this chromosome. Chromosome 21 was the second human chromosome to be fully sequenced, after chromosome 22.
Honey Bee Genome Sequencing Consortium
The Honey Bee Genome Sequencing Consortium is an international collaborative group of genomics scientists, scientific organisations and universities trying to decipher the genome sequences of the honey bee ("Apis mellifera"). It was formed in 2001 by American scientists. In the US, the project is funded by the National Human Genome Research Institute (a division of the National Institutes of Health (NIH)), the United States Department of Agriculture (USDA), the Texas Agricultural Experiment Station, the University of Illinois Sociogenomics Initiative, and various beekeepers association and the bee industry.
DNA encryption
In 2003, the National Human Genome Research Institute and its affiliated partners successfully sequenced the first whole human genome, a project that took just under $3 billion to complete. Four years later, James Watson – one of the co-discoverers of the structure of DNA – was able to sequence his genome for less than $1.5 million. As genetic sequencing technologies have proliferated, streamlined and become adapted to clinical means, they can now provide incredible insight into individual genetic identities at a much lower cost, with biotech competitors vying for the title of the $1,000 genome. Genetic material can now be extracted from a person's saliva, hair, skin, blood, or other sources, sequenced, digitized, stored, and used for numerous purposes. Whenever data is digitized and stored, there is the possibility of privacy breaches. While modern whole genome sequencing technology has allowed for unprecedented access and understanding of the human genome, and excitement for the potentialities of personalized medicine, it has also generated serious conversation about the ethics and privacy risks that accompany this process of uncovering an individual's essential instructions of being: their DNA sequence.
Molecular genetics
The Human Genome Project is a molecular genetics project that began in the 1990s and was projected to take fifteen years to complete. However, because of technological advances the progress of the project was advanced and the project finished in 2003, taking only thirteen years. The project was started by the U.S. Department of Energy and the National Institutes of Health in an effort to reach six set goals. These goals included:
Human Genome Project
It was far too expensive at that time to think of sequencing patients’ whole genomes. So the National Institutes of Health embraced the idea for a "shortcut", which was to look just at sites on the genome where many people have a variant DNA unit. The theory behind the shortcut was that, since the major diseases are common, so too would be the genetic variants that caused them. Natural selection keeps the human genome free of variants that damage health before children are grown, the theory held, but fails against variants that strike later in life, allowing them to become quite common (In 2002 the National Institutes of Health started a $138 million project called the HapMap to catalog the common variants in European, East Asian and African genomes).
Designer baby
Scientists have been able to better understand the genetic traits of humans through projects such as The Human Genome Project. This project was launched around 1990 and was an international research project that had an end goal of mapping and understanding every gene in the human body. As a part of the Human Genome Project, we have been able to pin point specific locations for about 12,800 specific genes within different chromosomes.
Human Epigenome Project
Human Epigenome Project (HEP) is a multinational science project, with the stated aim to "identify, catalog, and interpret genome-wide DNA methylation patterns of all human genes in all major tissues". It is financed by government funds as well as private investment, via a consortium of genetic research organisations.
1000 Genomes Project
The human genome consists of approximately 3 billion DNA base pairs and is estimated to carry around 20,000 protein coding genes. In designing the study the consortium needed to address several critical issues regarding the project metrics such as technology challenges, data quality standards and sequence coverage.
John Sulston
Sulston played a central role in both the "C. elegans" and human genome sequencing projects. He had argued successfully for the sequencing of "C. elegans" to show that large-scale genome sequencing projects were feasible. As sequencing of the worm genome proceeded, the Human Genome Project began. At this point he was made director of the newly established Sanger Centre (named after Fred Sanger), located in Cambridgeshire, England.
100,000 Genomes Project
The project was first announced by UK Prime Minister David Cameron in December 2012. The Government set up a new company Genomics England to oversee the project with the plan to focus on rare diseases, cancer and infectious diseases announced by Health Secretary Jeremy Hunt in July 2013. The project was also made possible by the National Institute for Health Research, NHS England, Public Health England and Health Education England. In 2015 Northern Ireland and Scotland also joined the project with plans to start work the following year. In 2016, the Welsh government issued a statement of intent and is considering participating in the 100,000 Genomes Project.
Cancer Genome Project
The Cancer Genome Project is part of the cancer, aging, and somatic mutation research based at the Wellcome Trust Sanger Institute in The United Kingdom. It aims to identify sequence variants/mutations critical in the development of human cancers. Like The Cancer Genome Atlas project within the United States, the Cancer Genome Project represents an effort in the War on Cancer to improve cancer diagnosis, treatment, and prevention through a better understanding of the molecular basis of the disease. The Cancer Genome Project was launched by Michael Stratton in 2000, and Peter Campbell is now the group leader of the project. The project works to combine knowledge of the human genome sequence with high throughput mutation detection techniques.
Nuclear DNA
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National Human Genome Research Institute
NHGRI began as the Office of Human Genome Research in The Office of the Director in 1988. This Office transitioned to the National Center for Human Genome Research (NCHGR), in 1989 to carry out the role of the NIH in the International Human Genome Project (HGP). The HGP was developed in collaboration with the United States Department of Energy (DOE) and began in 1990 to map the human genome. In 1993, NCHGR expanded its role on the NIH campus by establishing the Division of Intramural Research (DIR) to apply genome technologies to the study of specific diseases. In 1996, the Center for Inherited Disease Research (CIDR) was also established (co-funded by eight NIH institutes and centers) to study the genetic components of complex disorders.
Leroy Hood
The DNA sequencer was a critical technology for the Human Genome Project.
Hood was involved with the Human Genome Project from its first meeting, held at the University of California, Santa Cruz, in 1985. Hood became an enthusiastic advocate for The Human Genome Project and its potential. Hood directed the Human Genome Center’s sequencing of portions of human chromosomes 14 and 15.
Wellcome Sanger Institute
The Sanger Institute was opened in 1993, three years after the inception of the Human Genome Project, and went on to make the largest single contribution to the gold standard sequence of the human genome, published in 2004. The Institute was engaged in collaborations to sequence 8 of the 23 human pairs of chromosomes (1, 6, 9, 10, 13, 20, 22, and X). Since the publishing of the human genome, research carried out at the Institute has developed beyond sequencing of organisms into various biomedical research areas, including studies into diseases such as cancer, malaria and diabetes.
Walter Bodmer
Bodmer was one of the first to suggest the idea of the Human Genome Project. In 1987 he received the Ellison-Cliffe Medal from the Royal Society of Medicine. He was the director of research (1979–1991) and then Director General (1991–1996) of the Imperial Cancer Research Fund. He was also Chancellor of the University of Salford, England (1995–2005; succeeded by Sir Martin Harris) and Principal of Hertford College, Oxford (1996–2005; succeeded by Dr. John Landers).
Jane Grimwood
Grimwood was an important part of the Human Genome Project effort, working from the Stanford Human Genome Center. Grimwood stated, "I feel very lucky to have been a part of the Human Genome Project. It was arguably the best international collaborative project of our lifetime." She and her team worked on sequencing and analyzing chromosomes 5, 16, and 19 -- "320 million base pairs . . . comprising more than 10% of the human genome." They discovered that chromosome 19 has the highest gene density of any human chromosome, and were able to link certain genes on the chromosome to genetic diseases including insulin-resistant diabetes.
Microbiota
The Human Microbiome Project launched in 2008 was a United States National Institutes of Health initiative to identify and characterize microorganisms found in both healthy and diseased humans. The five-year project, best characterized as a feasibility study with a budget of $115 million, tested how changes in the human microbiome are associated with human health or disease.
Neanderthal genome project
The Neanderthal genome project is an effort of a group of scientists to sequence the Neanderthal genome, founded in July 2006.
Immunological Genome Project
The ImmGen project began in 2008, as a collaboration between several immunology and computational biology laboratories across the United States, and will be completing its second phase on 2017. Currently, raw data and specialized data browsers from the first and second phases are on www.ImmGen.org.
Michael Stratton
At the announcement of the completion of the Human Genome Project in 2000, Stratton discussed using genome sequences to revolutionise cancer treatment. He and Andy Futreal had already initiated the Cancer Genome Project at the Sanger Centre, as it was then known, to use genome-wide analysis to find somatic mutations in human cancers. According to fellow cancer researcher Chris Marshall, doing so prior to the completion of the human genome sequence was an "audacious idea." The aims of the project are to identify new cancer genes, to understand how cancers develop and to study how the structure of genomes influence cancer. In 2002 and 2004, Stratton's team discovered mutations in the BRAF and ERBB2 genes in approximately 60 per cent of malignant melanomas and 4 per cent of non-small-cell lung cancers respectively.
Eric D. Green
Dr. Green received his B.S. degree in bacteriology from the University of Wisconsin–Madison in 1981, and his M.D. and Ph.D. degrees from Washington University in 1987. During residency training in clinical pathology (laboratory medicine), he worked in the laboratory of Dr. Maynard Olson, where he launched his career in genomics research. In 1992, he was appointed Assistant Professor of Pathology and Genetics as well as a co-investigator in the Human Genome Center at Washington University. In 1994, he joined the newly established Intramural Research Program of the National Center for Human Genome Research, later renamed the National Human Genome Research Institute.
Joint Genome Institute
Originally established to work on the Human Genome Project—the JGI generated the complete sequences of Chromosomes 5, 16 and 19—the JGI has since shifted its focus to the non-human components of the biosphere, particularly those relevant to the DOE's science mission. Since 2004, the JGI has been a user facility that advances genomics research in a broad range of disciplines where DNA sequence information is likely to drive scientific discoveries.
Michael Smith (chemist)
Throughout the 1980s, Smith and his colleagues at the Canadian Institute for Advanced Research advocated for the establishment of a facility that would enable Canada to play a part in what had become known as the Human Genome Project. Eventually, funding was secured from the BC Cancer Agency and in 1999 the Genome Sequence Centre was established with a mandate to develop and deploy genomics technologies in support of the life sciences, and in particular cancer research. The Genome Sciences Centre also provided technology to Genome Canada and Genome BC projects in the areas of human health, the environment, forestry, agriculture, and aquaculture.
Vanessa Hayes
While at the CCIA, Hayes worked on the South African Genome Project with researchers from the University of New South Wales and Penn State University in the USA to compile the genome sequences of southern Africans, including Archbishop Desmond Tutu. Until this research, most human genome sequences had been derived from people of European origin. Hayes and her collaborators revealed in 2010 that the genetic diversity between people in southern Africa is greater than between other populations worldwide.
In 2010 Hayes joined the J. Craig Venter Institute in San Diego, California, USA, where she continued her research into human genetic diversity. That year she began leading a study sequencing DNA from a skeleton of an African hunter gatherer from around 315 BC found in St Helena Bay in South Africa. The DNA identified the skeleton as being from a man who was part of a previously unknown branch of the human family tree that diverged from the common lineage shared by all humans alive today. The study highlighted the significance of southern African archaeological remains in defining human origins and was published in the journal "Genome Biology and Evolution" in 2014.
Human Genome Sequencing Center
It occupies more than , employing over 200 staff, including eighteen faculty, and is one of three National Institutes of Health funded genome centers that were involved in the completion of the first human genome sequence in 2004. The BCM-HGSC contributed approximately 10 percent of the total project by sequencing chromosomes 3, 12 and X. The BCM-HGSC collaborated with researchers at the U.S. Department of Energy's Lawrence Berkeley National Laboratory and Celera Genomics to sequence the first species of fruit fly, "Drosophila melanogaster". The BCM-HGSC also completed the second species of fruit fly ("Drosophila pseudoobscura"), the honeybee ("Apis mellifera"), and led an international consortium to sequence the brown Norway rat.
Mammalian Genetics Unit
Earlier research on the same site at the Radiobiology Research Unit, which opened in 1954, in the 1950s was into cytogenetics, where Charles Edmund Ford and John Hamerton confirmed on 12 January 1956 the size of the human genome. In the early 1970s this unit led research into mutagenic effects of radiation on the human chromosome. In the mid-1980s, important early work was done in genomic imprinting.
Cooperative Human Linkage Center
CHLC (or Cooperative Human Linkage Center) was a NIH project to map a large number of human genome markers, prior to the completion of the Human Genome Project. The project was stopped in 1999