Is Scrapie like Mad Cow Disease?
Tikvah Alper
Scrapie is a fatal infectious disease of the neural system of sheep; one of a class of brain diseases that can affect cattle (BSE) and humans (Kuru, nCJD). Scrapie had been thought to be caused by a 'slow virus' – one that could take years to show as a change in behaviour or movement. By the mid 1960s, it was established that cells could only replicate via DNA. Radioactivity stops cell replication by 'killing' DNA. Alper found that radiation did not kill the infective agent in scrapie, suggesting that a virus was unlikely to be the infective agent. The infective agent had to be smaller and simpler than (viral) DNA. Alper also found that the agent remained active under ultraviolet light. DNA is inactive under UV light. Instead, the agent was killed by light at 237 nm, a wavelength specific to polysaccharide inactivation. Alper and colleagues reported these properties of the scrapie agent – a finding that was greeted with astonishment in many quarters, for it appeared to contravene the central dogma that holds that replication (and hence the growth of the disease and its infectious properties) can only proceed via DNA. However, once these empirical findings were accepted, several theories developed to accommodate the peculiar properties of the scrapie agent. The most widely accepted theory today is the prion theory, which posits a 'rogue' protein as the infectious source. However, Alper could not accept that a protein 'mutation' was the agent. Firstly, her UV radiation studies did not indicate a protein agent and, secondly, isolated prions did not induce scrapie. Her own theories concerning the agent were developed in the last years of her life and suggested a more dynamic and complex story.
Canine epileptoid cramping syndrome
Canine epileptoid cramping syndrome (CECS), previously known as Spike's Disease, is a hereditary disease of Border Terrier dogs, with similarities to canine epilepsy. The cause is unknown.
In 2015 a study came to the conclusion that: "Canine epileptoid cramping syndrome in Border Terrier's is a gluten-sensitive movement disorder triggered and perpetuated by gluten and thus responsive to a gluten-free diet."
Bree Van de Kamp
Bree is spoofed in "MADtv"'s "Desperate Housewives" parody, in which they mock the character's plastic exterior and demeanor. In a 2006 interview with "Charmed Magazine", Michelle Stafford admitted that her character Mandi in "Charmed" episode "Desperate Housewitches" was almost entirely modeled on Marcia Cross as Bree. Looking at pictures and episodes of Bree to gain a sense of her posture and body language, she laughed, "I'm just mimicking her. I'm just ripping her off."
Mad Man Pondo
Canady hosted his own Public-access television show in the late nineties. The program, which featured nude women, cursing, and wrestling, attracted the attention of television personality Jerry Springer. First being brought in to portray several different guests on Springer's "The Jerry Springer Show", Canaday was later hired to find actors to appear as guests on the show. In 2005, he appeared in director Tim Sullivan's horror movie "2001 Maniacs" as the town's blacksmith. As Mad Man Pondo, Canady is a playable character in the video games "", "", and "Fire Pro Wrestling Returns".
Brood parasite
There are two avian species that have been speculated to portray this mafia-like behavior: the brown-headed cowbird of North America, "Molothrus ater", and the great spotted cuckoo of Europe, "Clamator glandarius". The great spotted cuckoo lays the majority of its eggs in the nests of the European magpie, "Pica pica". It repeatedly visits the nests that it has parasitised, a precondition for the mafia hypothesis. An experiment was run by Soler "et al." from April to July 1990 – 1992 in the high-altitude plateau Hoya de Guadix, Spain. They observed the effects of the removal of cuckoo eggs on the reproductive success of the magpie and measured the magpie's reaction; the egg was considered accepted if it remained in the nest, ejected if gone in between visits, or abandoned if eggs were present but cold. If any nest contents were gone between consecutive visits, the nests were considered to have been depredated. The magpie's reproductive success was measured by number of nestlings that survived to their last visit, which was just before the nestling had been predicted to fledge from the nest. The results from these experiments show that after the removal of the parasitic eggs from the great spotted cuckoo, these nests are predated at much higher rates than those where the eggs were not removed. Through the use of plasticine eggs that model those of the magpie, it was confirmed that the nest destruction was caused by the great spotted cuckoo. This destruction benefits the cuckoo, for the possibility of re-nesting by the magpie allows another chance for the cuckoo egg to be accepted.
Chromatolysis
Severe neuronal chromatolysis has been detected in the brainstems of adult cattle with the neurodegenerative condition known as idiopathic brainstem neuronal chromatolysis (IBNC). The symptoms of IBNC in cattle are clinically similar to those characterized by bovine spongiform encephalopathy, otherwise known as mad-cow disease. These symptoms included tremor, lack of muscle movement coordination, anxiety and weight loss. At the cellular level, IBNC is marked by the degeneration of neurons and axons within the brainstem and cranial nerves. The disease also has a significant correlation with abnormal labeling for prion protein (PrP) in the brain. IBNC has been characterized by severe neuronal, axonal, and myelin degradation, accompanied by non-supportive inflammation and changes in spongiform of various regions of grey matter. A significant loss of neurons due to hippocampal degeneration has also been observed. The degenerate chromatolysis neurons seldom showed intracytoplasmic labeling for PrP.
Bradford Scobie
Other bizarre characters created by Scobie include the self-loathing clown Ukulele Louie, the "spitty and adorable man-child" Bratwurst, and Cousin Rooster, a hillbilly who has sex with chickens. As Zombie Ralph he worked as "Master of Scare-a-Moanies" for "BOO-LESQUE WITH ZOMBIE RALPH", a goofy Halloween-themed show at Joe's Pub in 2008.
Cattle
Cattle diseases were in the center of attention in the 1980s and 1990s when the Bovine spongiform encephalopathy (BSE), also known as mad cow disease, was of concern. Cattle might catch and develop various other diseases, like blackleg, bluetongue, foot rot too.
Miniature Shar Pei
Many of this breeds health issues depend upon the lines that the dog comes from. Dogs with few hereditary issues will tend to be healthier than ones whose parents or grand parents had problems. One misconception about the health of the Miniature Shar Pei is that its wrinkles lead to skin problems. A healthy dog's wrinkles should not require any special care. The wrinkles can cause other issues, occasionally puppies have so many wrinkles that the excess skin covers the dogs eyes and puts pressure on the eyelids causing them to rub on the cornea. This symptom is called entropion and can usually be corrected through a process called "tacking" where by using stitches to temporarily hold the wrinkles away from the eyes, the puppy is given time to grow into its skin. In severe cases where tacking is unsuccessful, an operation may be needed to surgically remove the excess skin around the dogs eyes. Like the larger Standard Shar Pei, Swollen Hocks Syndrome is sometimes seen in this breed and if not treated can lead to Amyloidosis resulting in Kidney Failure. Other than these few issues the breed tends to be relatively healthy requiring only routine visits to the vet.
Chaperonin
Chaperonins are proteins that provide favourable conditions for the correct folding of other proteins, thus preventing aggregation. They prevent the misfolding of proteins, which prevents diseases such as Mad Cow Disease. Newly made proteins usually must fold from a linear chain of amino acids into a three-dimensional form. Chaperonins belong to a large class of molecules that assist protein folding, called molecular chaperones. The energy to fold proteins is supplied by adenosine triphosphate (ATP). Chaperonin proteins may also tag misfolded proteins to be degraded.
Mad Pigeon
- Super Spotless and Grimy Girl
Scraper (band)
Scraper was a hardcore punk band from the West Midlands of the United Kingdom. Influenced by a variety of Punk rock and Hardcore punk bands, Scraper were likened to Snuff, Leatherface, China Drum, Hüsker Dü and even Fast Eddie period Motörhead. Scraper became popular throughout the latter half of the 1990s with strong followings around Birmingham, London and Cardiff. Towards the end of the 1990s Scraper renamed themselves "Turnbull ACs". Scraper's 1996 album "Built with Hate" received 4 and a half out of 5 in Terroriser Magazine and 4 out of 5 in Kerrang!.
The Shrine (Stargate Atlantis)
The episode focuses on Dr. Rodney McKay, who has been infected with a disease known as "Second Childhood", which is considered the Pegasus equivalent of fast on-set Alzheimer's disease, where he quickly reverts to a childlike state. The only way for the team to save him is to send him to a shrine on the planet of Talus, which has since turned into a Wraith outpost.
List of Tom and Jerry characters
McWolf, initially named 'Slick Wolf' is the villain of the "Droopy and Dripple" segments. A bad and cruel wolf whose only mission is to ruin the life of Droopy (and Dripple and sometimes to remain with Miss Vavoom in "Tom & Jerry Kids"). Sometimes for of crazy scientist whom it loves to dominate the world, of space villain, a criminal fat person (known as "The Chubby Man"), etc. His character is based on the wolf in "Red Hot Riding Hood". He is voiced by Frank Welker.
The Hand That Rocks the Wheelchair
Along with the episode's title, the Meg and Joe plot line heavily borrows from the storyline, as well as several scenes, of "The Hand That Rocks the Cradle". The scene where Evil Stewie appears in the empty machine is a direct homage to the "Star Trek" episode "The Enemy Within," down to the lighting and piano fill, which has a similar premise involving an evil duplicate of Captain Kirk. While driving Meg to school, Joe asks what a Lady Gaga is. Stewie shown with yellow eyes and Vincent Price's laughter is a direct reference to Michael Jackson's "Thriller" music video. The evil Stewie acts like "Chucky," the main villain from the "Child's Play" series by David Kirschner and Don Mancini, including the way he attacked Brian, and killing people with weapons.
Biz Markie
In 1996, Markie appeared on the Red Hot Organization's compilation CD, "America is Dying Slowly", alongside Wu-Tang Clan, Coolio, and Fat Joe, among others. The CD, meant to raise awareness of the AIDS epidemic among African American men, was heralded as a masterpiece by The Source magazine.
Mark Purdey
John Mark Purdey (25 December 1953 – 12 November 2006) was an English organic farmer who came to public attention in the 1980s, when he began to circulate his own theories regarding the causes of bovine spongiform encephalopathy (BSE or "mad cow disease").
List of Winnie-the-Pooh characters
A very large sheepdog belonging to a neighbor of Christopher Robin's. He appears in "Sorry, Wrong Slusher" and "A Pooh Day Afternoon". He is a nice dog, but sometimes makes trouble for the characters. Piglet is afraid of him (as shown in "Sorry, Wrong Slusher", where he thinks Skippy is the "slusher" that Christopher Robin and the animals are afraid of). Unlike other animal characters, Skippy is not anthropomorphized.
English Springer Spaniel
The English Springer Spaniel has a typical lifespan of 10.5 to 15 years. As in most breeds, there are some health problems that are more likely to occur. Hip dysplasia and progressive retinal atrophy (PRA) (a degeneration of the retina causing vision loss leading to blindness) are two such diseases for which veterinarians are working on genetic markers to determine carriers. Another problem can be elbow dysplasia. Retinal dysplasia (RD), which can cause blindness and Phosphofructokinase deficiency (PFK), which is genetic deficiency which impairs the ability of cells using carbohydrates for energy are two other hereditary conditions for which both lines of the English springer spaniel should be screened prior to breeding. Health issues are usually similar in both types of English Springer however phosphofructokinase deficiency in particular can appear more in field lines, however carriers in show lines have been identified.
Thomas Roderick Dew
Dew was well respected in the South; his widely-distributed writings helped to confirm pro-slavery public opinion. His work has been compared to that of the Southern surgeon and medical authority Samuel A. Cartwright, who defended slavery and invented the diseases of drapetomania (the madness that makes slaves want to run away), and dysaesthesia aethiopica ("rascality"), both cured with beatings. His 1833 "Review" was republished in 1849, and collected in "The Pro-Slavery Argument", together with writings by Harper, Hammond and Simms.
Hexie Farm
The author of "Hexie Farm" remains anonymous for safety reasons; no photo or personal information of him has been released. He is simply referred to with the pen name of Crazy Crab. He is a fan of "Calvin and Hobbes" as well as "Snoopy". He began drawing political cartoons after reading news about Feng Zhenghu, and Tang Fu-zhen self-immolation incident.
Scrapie
In the UK, the Blair ministry implemented in 2001 a "National Scrapie Plan", which encouraged breeding from sheep that are genetically more resistant to scrapie. This is intended to eventually reduce the incidence of the disease in the UK sheep population. Scrapie occurs in Europe and North America, but to date, Australia and New Zealand (both major sheep-producing countries) are scrapie-free. In 2003, there was pressure from previously-sinistered Canadian husbandry practitioners on the Chretien government and their CFIA to implement their own NSP.
Camel spongiform encephalopathy
camel spongiform encephalopathy commonly known as mad camel disease This disease, similar to mad cow disease, was discovered by two Algerian researchers, among them Dr Baaissa Babelhadj, veterinarian of the slaughter of the city of Ouargla in coordination with Italian researchers, This infection is a new form of prion disease and a type of Transmissible spongiform encephalopathy that affects for the first time non-ruminant mammals (camels) and is associated with mad cow disease in the characteristics of the ability to move to other animal species and to human consumers.
Crash Holly
Lockwood signed a contract with NWA Total Non-Stop Action (later known as Total Nonstop Action Wrestling) in July 2003 and debuted as Mad Mikey on July 23, accepting an open challenge from Elix Skipper and losing the match. Mad Mikey was angry at many things, on which he elaborated in promos. He wrestled on nine NWA-TNA weekly PPVs, lastly on October 1.
Mad Dogs (UK TV series)
Ryan Lambie of "Den of Geek" said of the first episode; "In terms of writing and acting, "Mad Dogs" is good, but not perfect, and much of its knock-about banter is uncannily like any Brit gangster flick you've ever seen," like ""Sexy Beast: the series"." However Lambie noted "when events push its premise from naff lads' drama into exotic thriller, "Mad Dogs" gets infinitely better, and if nothing else, it keeps you guessing. As the series progressed, Lambie noted that "Mad Dogs" was "developing into a nifty TV thriller with an engaging sense of the absurd. Writer, Cris Cole, enjoys picking holes in his characters' machismo as the tension mounts, and the strange billboard posters dotted all over the sun-scorched island, which say "Yenda a ninguna parte," ("Going nowhere") are perhaps a foreshadowing of their imminent fate." Lambie was disappointed at the ending, calling it "unexpectedly flat," adding "the major plot twist that the previous three-or-so hours appeared to allude to never arrives, [...] I couldn't help but feel that, as the closing credits rolled on the whole saga, the tension and intrigue that had gradually built up in previous weeks had been allowed to slip away.
Deer farm
Since Chronic Wasting Disease (CWD), a transmissible spongiform encephalopathy similar to Mad Cow Disease, can pass from wild populations of deer to deer in farms, there has been some fear of contamination of the food supply. Recently, cases of CWD have been found in both farmed and wild cervids in the US and western Canada.
Scrapie
Various studies have indicated prions (PrP) that infect sheep and goats with the fatal transmissible encephalopathy known as scrapie, are able to persist in soil for years without losing their pathogenic activity. Dissemination of prions into the environment can occur from several sources: mainly, infectious placenta or amniotic fluid of sheep and possibly environmental contamination by saliva or excrement.
List of Coronation Street characters (2014)
In September 2014, Kylie returns to see Dr. Gaddas in asking for a re-supply of the medication that Max had been diagnosed with for his ADHD. She tells Dr. Gaddas that she has accidentally thrown one strip of the tablets away and Dr. Gaddas replaces the lost items. In reality, Kylie has been taking the tablets herself, unable to cope with the strain of Max's ADHD. Michael Rodwell (Les Dennis) is later seen visiting Dr. Gaddas when he begins to suffer with heart problems. He is eventually diagnosed with a genetic heart condition, which led to him having open-heart surgery. In November 2014, Steve McDonald (Simon Gregson), deep into a bout of untreated depression visits the surgery with great reluctance. He had previously seen a locum, Dr. Robinson, who had suspected his condition and when Steve sees that he is not behind the desk, he suffers a panic attack. Dr. Gaddas calms him down and takes him through a questionnaire, with confirms Dr. Robinson's diagnosis of depression. Like Dr. Robinson, Dr. Gaddas tells Steve he should see a counsellor or talk to someone to unburden himself. Steve gives his mother, Liz (Beverley Callard) as a possible person to do this with. When Dr. Gaddas sees Steve in the street at the end of the day, he confirms that he had taken no action and she warns him that he has to deal with his depression or it will only worsen.
Scalped (comics)
Chief Lincoln Red Crow (Lakota: Kangi Sa), a.k.a. John Rayfield Bustill, a bullish Lakota elder in his fifties, Red Crow's professional demeanor conceals a cold determination to elevate his Reservation beyond their dire surroundings, no matter the cost. A "big man" on the reservation with fingers in many pies, he is President of the Oglala Tribal Council, Sheriff of the Tribal Police Force and Managing Director of the Crazy Horse, his chief project since leaving the Native American Rights movement. The need to balance feuding parties with conflicting interests, as well as raising the necessary funds, has led him into a position of a local crime lord, managing his interests in drugs, prostitution and arms dealing. Publicly and privately, Red Crow is not shy about drawing attention to the overwhelming problems of the reservation, or his efforts to reduce them, statements dismissed by his critics who claim he's merely a mob boss presiding over a criminal empire feeding off the reservation.
TJ Dawe
Dawe has worked extensively in fringe theatre festivals in Canada and the US. Other festival appearances include the Montreal Just for Laughs Festival, Piccolo Spoleto, the Edinburgh Fringe and the Adelaide Fringe. He wrote and performed the monologues "Tired Cliches", "Labrador", "The Slipknot", "Tracks" (adapted from Jack London’s memoir The Road), "A Canadian Bartender at Butlin's", "The Curse of the Trickster", "Maxim and Cosmo", "Totem Figures", "Lucky 9", "Medicine", and "Marathon". He co-wrote the plays "52 Pick-up" (with Rita Bozi), "Toothpaste and Cigars" (with Mike Rinaldi), "The Power of Ignorance" (with Chris Gibbs), and "Dishpig" (with Greg Landucci). He adapted "The Doctor is Sick" from the novel by Anthony Burgess. He directed "The One Man Star Wars Trilogy", "One Man Lord of the Rings", "Teaching As You Like It", "Teaching the Fringe", "Rant Demon", "Local Celebrity", "Mr Fox" and "The Big Oops".
Michael Greger
Greger went to college at Cornell University School of Agriculture, where as a junior he wrote informally about the dangers of bovine spongiform encephalopathy, commonly known as mad cow disease, on a website he published in 1994. In the same year, he was hired to work on mad cow issues for Farm Sanctuary, near Cornell, and became a vegan after touring a stockyard as part of his work with Farm Sanctuary. In 1998, he appeared as an expert witness testifying about bovine spongiform encephalopathy when cattle producers unsuccessfully sued Oprah Winfrey for libel over statements she had made about the safety of meat in 1996.
Agricultural policy
Bovine spongiform encephalopathy (BSE), commonly known as "mad cow disease", is a fatal, neurodegenerative disease of cattle, which infects by a mechanism that surprised biologists upon its discovery in the late 20th century. In the UK, the country worst affected, 179,000 cattle were infected and 4.4 million killed as a precaution. The disease can be transmitted to human beings who eat or inhale material from infected carcasses. In humans, it is known as new variant Creutzfeldt–Jakob disease (vCJD or nvCJD), and by June 2007, it had killed 165 people in Britain, and six elsewhere with the number expected to rise because of the disease's long incubation period. Between 460,000 and 482,000 BSE-infected animals had entered the human food chain before controls on high-risk offal were introduced in 1989.
Cannibalism
Bovine spongiform encephalopathy, or mad cow disease is another prion disease which is usually caused by feeding contaminated bovine tissue to other cattle. It is a neurodegenerative disease and could be spread to humans if the individual were to consume contaminated beef. The spread of parasites such as nematodes may also be facilitated by cannibalism as eggs from these parasites are transferred more easily from one host to another.
American Cocker Spaniel
American Cockers are also prone to canine epilepsy and the related condition known as Rage Syndrome. The latter is a form of epilepsy which can cause a normally placid dog to engage in sudden and unprovoked violent attacks. Initial research shows that both conditions appear to be inheritable.
Smalahove
Since 1998 and the mad cow epidemics, an EU directive forbids the production of "smalahove" from adult sheep, due to fear of the possibility of transmission of scrapie, a deadly, degenerative prion disease of sheep and goats, though scrapie does not appear to be transmissible to humans. It is now only allowed to be produced from the heads of lambs.
Scrapie
The disease has been notifiable in the EU since 1993 but unlike BSE there was no evidence as of 1999 to suggest that scrapie is a risk to human health. In July 2003, a Canadian Food Inspection Agency officer said that while scrapie shows up every year on Canadian farms, "We've had a lot of experience with scrapie and there's never been a link between scrapie and human illness." As of 2004, the USDA made no mention of scrapie in its "Sheep and Goats Death Loss" circular.
Transmissible spongiform encephalopathy
In the 5th century BCE, Hippocrates described a disease like TSE in cattle and sheep, which he believed also occurred in man. Publius Flavius Vegetius Renatus records cases of a disease with similar characteristics in the 4th and 5th centuries AD. In 1755, an outbreak of scrapie was discussed in the British House of Commons and may have been present in Britain for some time before that. Although there were unsupported claims in 1759 that the disease was contagious, in general it was thought to be due to inbreeding and countermeasures appeared to be successful. Early-20th-century experiments failed to show transmission of scrapie between animals, until extraordinary measures were taken such as the intra-ocular injection of infected nervous tissue. No direct link between scrapie and disease in man was suspected then or has been found since. TSE was first described in man by Alfons Maria Jakob in the 1921. Daniel Carleton Gajdusek's discovery that Kuru was transmitted by cannibalism accompanied by the finding of scrapie-like lesions in the brains of Kuru victims strongly suggested an infectious basis to TSE. A paradigm shift to a non-nucleic infectious entity was required when the results were validated with an explanation of how a prion protein might transmit spongiform encephalopathy. Not until 1988 was the neuropathology of spongiform encephalopathy properly described in cows. The alarming amplification of BSE in the British cattle herd heightened fear of transmission to humans and reinforced the belief in the infectious nature of TSE. This was confirmed with the identification of a Kuru-like disease, called new variant Creutzfeldt–Jakob disease, in humans exposed to BSE. Although the infectious disease model of TSE has been questioned in favour of a prion transplantation model that explains why cannibalism favours transmission, the search for a viral agent is being continued in some laboratories.
Mad Caddies
The Mad Caddies sound has influences from broad ranging genres including ska (especially ska 3rd wave), punk rock, hardcore punk, reggae, dixieland jazz, Latin music, polka, even cowpunk ("Crew Cut Chuck") and sea shanties ("Weird Beard").
Charles McPhee
In March 2006, McPhee became aware of problems with his voice. After a number of tests, he was diagnosed with probable amyotrophic lateral sclerosis (ALS) (Lou Gehrig's disease) in June 2006. After the diagnosis was confirmed in August 2006, McPhee announced the news to his audience that he had Bulbar ALS, a severe form of the disease. The final Dream Doctor Radio Show was broadcast on October 20, 2006.
Hyperion (comics)
Scientists in the mainstream 616 reality graft the DNA of the Earth-712 Squadron Supreme members to normal human corpses and zap them with radiation in an attempt to create a Squadron Supreme for their reality. The bodies are reanimated as zombies, and, believing themselves to be the original Squadron Supreme, they attempt to escape the lab facility. Hyperion is successful and goes on an eating rampage, but eventually dies of mad cow disease, which he contracts when eating cattle.
Cavalier King Charles Spaniel
Hip dysplasia is a common genetic disease that affects Cavalier King Charles Spaniels. It is not present at birth but develops with age. Hip dysplasia is diagnosed by X-rays, but it is not usually evident in X-rays of Cavaliers until they mature. Even in adult spaniels with severe hip dysplasia, X-rays may not always indicate the disease. In a series of evaluations by the Orthopedic Foundation for Animals, the Cavalier was ranked 78th worst out of 157 breeds. The worst affected breeds were the Bulldog, Pug and Dogue de Bordeaux.
Rodney McKay
McKay is a hypochondriac, claiming at various times to suffer from hypoglycemia, restless leg syndrome, allergy to bee stings and citrus fruit, none of which have ever been confirmed. He enjoys veal, MREs, hospital food, and airline food. He studied medical science at one time, but stopped because too much information on the human body made him start diagnosing himself with many phantom diseases. McKay comes up with his most brilliant ideas while faced with the threat of death.
Robbie Rage
During his recovery for a rotator cuff tear, Knapik became depressed before being released from WCW during his recovery. Soon afterwards he began using, and ultimately became addicted to, painkillers and ecstasy in order to combat his depression. Knapik also lost his home, several cars and a house in Florida due to being unable to pay for them all. After becoming sober, Knapik became a born again Christian.
Cooties
Cooties is a fictitious childhood disease, used in the United States and Canada as a rejection term and an infection tag game (such as Humans vs. Zombies). It is similar to the British dreaded lurgi, and to terms used in the Nordic countries, in Italy, Australia and New Zealand. A child is said to "catch" cooties through close contact with an "infected" person or from an opposite-sex child of a similar age.
Growth hormone therapy
In 1976, physicians became aware that Creutzfeldt–Jakob disease could be transmitted by neurosurgical procedures and cornea transplantation. CJD is a rapidly fatal dementing disease of the brain also known as spongiform encephalopathy, related to “mad cow disease”.
Title 9 of the Code of Federal Regulations
This subchapter, titled "Cooperative Control and Eradication of Livestock or Poultry," lists additional rules of procedure, as well as guidelines and restrictions regarding animal destruction due to Tuberculosis, Brucellosis, Pseudorabies, Foot-and-mouth disease, Rinderpest, Pleuropneumonia, and other communicable diseases. It also lists guidelines for control of Scrapie, Chronic Wasting Disease, and H5/H7.
Nancy E. Krulik
Krulik is the author and creator of several book series, beginning with "Katie Kazoo, Switcheroo" in 2002. The "How I Survived Middle School" series launched in June 2007. In July 2008, Grosset and Dunlap (a division of Penguin Young Readers) launched the "George Brown, Class Clown" series, a spin-off of Katie Kazoo, with the book "Super Burp". Her mystery series for kids, "Jack Gets a Clue" launched in 2011. In 2013, she published the "Magic Bone" series, which follows the adventures of Sparky, a sheepdog puppy, who travels the world thanks to the magic he finds in a very special chew toy. The first two books in the series: "Be Careful What You Sniff For" and "Catch that Wave" were published in May. Krulik followed that series with Project Droid, a science fiction series of six books written with her daughter Amanda Burwasser, The Kid From Planet Z (a young chapter book series about a family who crashes down on earth and must follow the instructions of their leader, a talking cat named Zeus), and Princess Pulverizer, a series about a princess who wants to be a knight and must go on a Quest of Kindness to prove that she is up to the task. Along the way Princess Pulverizer meets up with a dragon who uses his fire to make grilled cheese, and a timid knight-in-training who has been nicknamed Lucas the Lily-Livered.
Touch Me I'm Sick
Critics have noted a Stooges influence in "Touch Me I'm Sick", typical of Mudhoney's early material. Turner said: "In retrospect, it's The Yardbirds' 'Happenings Ten Years Time Ago' by way of The Stooges' 'Sick of You'. At the time I was trying for the stuttering R&B guitar of The Nights and Days." The song is also reminiscent of the hardcore punk of Black Flag. In his book "Loser: The Real Seattle Music Story", Clark Humphrey accuses the song of being a copy of "The Witch" by The Sonics. The band have dismissed this claim, and questioned the writer's knowledge of music.
The Scrap Iron Rhythm Revue
Their 1969 debut single "(I Wanna Love You Like a) Mad Dog" opens the compilation. According to Stanley, the song "sounds like a one-man oompah band" that has been phased to "simulate an psychedelic experience." It features tongue-in-cheek sexual lyrics that Stanley compared to the controversial lyrics of Marie Lloyd. "Edna" is a pop song with the high pitched refrain – sung by either Woodward or Fletcher – of "Ed-ed, Ed-ed, Ed-ed-ed-ed-Edna, let me sing my beautiful song." The BBC described the song's vocals as "quirky" yodelling. In comparing the band's eclectic array of styles, they also felt it contrasted with the rock and roll-styled "Runaround Sue".
À la Table de Spanghero
In March 2013, food inspectors found 57 tonnes of frozen sheepmeat at Spanghero, that had been imported from the United Kingdom and that included mechanically recovered meat (MSM). MSM is banned in the European Union, as it may contain fragments of bone. Bones of bovines, ovines or caprids may not be imported into EU countries from countries with a risk of spongiform encepalopathies; this includes the UK, following the mad cow disease outbreak of the 1990s, and the prevalence of scrapie among sheep there. Spanghero blamed its supplier Draap (the Dutch word for "horse" reversed) for false labelling.
The Winjin Pom
Ronnie and Reggie, the Crow Twins: a pair of nasty but single-minded crows, Ronnie and Reggie are twin brothers, and J.G.'s snivelling, incompetent associates. They occasionally manage to hijack the Winjin' Pom, but systematically end up failing. Named after the Kray Twins, the famous London gangland mobsters. The Crows, who also have a mother (I wonder if her name is Violet?), are voiced by comedy pair Mark Arden and Stephen Frost of "Carling Black Label" fame.
Wrong Eye/Scope
According to Brainwashed.com: "Wrong Eye" is described by Coil as being a "rough sketch" of the track "Windowpane." Coil has also stated that speculation about "Scope" being an early version of "Her Friends The Wolves" (from Stolen and Contaminated Songs) is false, and that the track was actually a "studio jam" fueled by "experimenting with MDMA".
Structural inheritance
Examples of structural inheritance include the propagation of prions, the infectious proteins of diseases such as scrapie (in sheep and goats), bovine spongiform encephalopathy ('mad cow disease') and Creutzfeldt–Jakob disease (although the protein-only hypothesis of prion transmission has been considered contentious until recently). Prions based on heritable protein structure also exist in yeast. Structural inheritance has also been seen in the orientation of cilia in protozoans such as "Paramecium" and "Tetrahymena", and 'handedness' of the spiral of the cell in "Tetrahymena", and shells of snails. Some organelles also have structural inheritance, such as the centriole, and the cell itself (defined by the plasma membrane) may also be an example of structural inheritance. To emphasize the difference of the molecular mechanism of structural inheritance from the canonical Watson-Crick base pairing mechanism of transmission of genetic information, the term 'Epigenetic templating' was introduced.
Crooked I
On November 10, 2009, Crooked I released a digital-only solo EP, "Mr. Pig Face Weapon Waist". "It’s a spin-off of my Slaughterhouse alter ego," he said of the odd title, "cause I come out on stage with a pig mask and a Dickie suit on." The EP also boasts guest appearances from Snoop Dogg, K. Young, M.O.P., The Horseshoe G.A.N.G., and of course fellow Slaughterhouse members, Joe Budden, Joell Ortiz, and Royce da 5'9". In addition to production from Komplex, Scram Jones, Streetrunner, Frequency, and P. Silva.
Chronic wasting disease
The cause of CWD (like other TSEs, such as scrapie and bovine spongiform encephalopathy) is believed to be a prion, an misfolded form of a normal protein, known as prion protein (PrP), that is most commonly found in the central nervous system (CNS) and Peripheral nervous system (PNS). The misfolded form has been shown to be capable of converting normally folded prion protein, PrP ("C" for cellular) into an abnormal form, PrP ("Sc" for Scrapie) thus leading to a chain reaction. It is by this mechanism that CWD is thought to be transmitted. The abnormality in PrP has its genetic basis in a particular variant of the protein-coding gene "PRNP" that is highly conserved among mammals and has been found and sequenced in deer. The build-up of PrP in the brain is associated with widespread neurodegeneration.
However, the prion cannot be detected in about 10% of CJD cases, leading some to suspect something else causes the diseases and that the prion is just a marker of infection. Another theory that has gained some support since 2017 is that the cause is a cell-wall deficient bacterium called Spiroplasma. Frank Bastian of Louisiana state university has long been unsucsesfully trying to grow Spiroplasma from the brains of infected animals, where it would grow for about 10 hours, then die. Bastian claims to have sucsesfully cultured Spiroplasma from the brains of 100% of deer with CWD and sheep with Scrapie after changing the growth medium. As a result, a Pennsylvania hunting agency, Unified Sportsmen of Pennsylvania, and scientists at the University of Alabama are getting interested in his work. Spriroplasma possesses many of the properties of the CWD agent, including resistance to heat and radiation, and it is thought that the body may trigger prion formation as a defense mechanism against Spiroplasma.
The Unfunnies
Moe the Crow – a cartoon crow. Married to Birdseed Betty, has two kids Timmy and Molly. He is arrested and jailed for possession of child pornography (provided to him by Troy Hicks). Becomes a prison “bitch” to the other inmates. Is eventually raped by a bulldog in prison with AIDS.
Scrapie
Some sheep scratch excessively and show patches of wool loss and lesions on the skin. Scratching sheep over the rump area may lead to a nibbling reflex, which is characteristic for the condition.
Prion
Several scientific observations remain unexplained by the prion hypothesis: It is known that mice with severe combined immunodeficiency do not develop scrapie following inoculation with brain tissue from animals infected with scrapie, suggesting that either the role of immunity in prion pathogenesis is incompletely understood or that there is some other flaw in current understanding of prion pathophysiology. More recently, it has been shown that scrapie and Creutzfeldt–Jakob disease may require agent-specific nucleic acids for transmission of infection. For these reasons, the prion/TSE hypothesis incompletely accounts for the observed data.
Mad Pigeon
- It lives on Mars
List of Crash Bandicoot characters
In "Crash Twinsanity", Brio teams up with Doctor Nefarious Tropy to defeat Crash and steal the Evil Twins' treasure. He appears alongside Tropy in a boss fight, immediately following Crash's escape from N. Gin's battleship, in which Brio (after being instructed by N. Tropy to "get changed") drinks a potion to transform himself into a large, green frog-like monster. He then appears (in his human form) alongside N. Tropy and N. Gin again in the Evil Twins' fortress, claiming the Twins' treasure for themselves. However, they are thwarted by Spyro the Dragon, who had been trapped in the Twins' vault. Brio reunites with Neo Cortex once more in "Crash: Mind over Mutant", in which he aids in the development of the NV, a personal digital assistant that can control both mutants and bandicoots. He uses recycled parts from the Sludge Junkyard to mass-produce NVs and create a new space station for Doctor Cortex. Throughout the game, he claims to be the inventor of numerous things, including recycling, Slinkies and endings (though he does acknowledge he did not invent LiteBrite). He is found in the Junkyard with a brainwashed Crunch Bandicoot by Crash and Aku Aku, who are then attacked by Crunch under Brio's orders. When Crunch is broken free from the NV's control, Brio is forced to reveal the whereabouts of Uka Uka, who is acting as the source of the negative Mojo needed to control those wearing NVs. He is then told to leave the island, but promises that it is not the end.
Disney Channel
In December 2011, Disney Channel pulled episodes of two of its original series from the network's broadcast cycle – the season one "Shake It Up" episode "Party It Up," and the "So Random!" episode "Colbie Caillat" – after Demi Lovato (star of "So Random!" parent series "Sonny with a Chance", who was treated for bulimia nervosa in 2010) objected on Twitter to jokes featured in both episodes (the "Shake It Up" episode, in particular) that made light of eating disorders. On May 17, 2013, the channel pulled "Quitting Cold Koala", a second-season episode of "Jessie", prior to its scheduled premiere broadcast, due to parental concerns over a scene in which a character's gluten-free diet leads to his being ridiculed.
National Institute for Mathematical and Biological Synthesis
One area of particular emphasis at NIMBioS has been modeling animal infectious diseases, such as white-nose syndrome in bats, pseudo-rabies virus in feral swine, Toxoplasma gondii in cats, and malaria from mosquitoes. As a leading international center for animal infectious disease modeling, NIMBioS has contributed significantly to global needs in analyzing the potential spread, impact and control of diseases that can move from animals to humans, such as West Nile virus, anthrax, swine flu and mad cow disease. NIMBioS also collaborates with the Great Smoky Mountains National Park to develop methods of particular interest for natural area management that are transferable to numerous U.S. locations.
Scrapie
"With scrapie, the archetypical TSE, which is a natural disease in sheep and goats, the disease can appear suddenly in a flock in the absence of any known exposure to infected flocks (Palsson, 1979). Finally, fields in Iceland, that were left empty for up to 3 years after the destruction of scrapie-infected flocks, were repopulated with known scrapie-free sheep, and some of the sheep in this latter group subsequently developed scrapie (Palsson, 1979). This last 'experiment in nature' has yielded similar results a number of times in Iceland and in the United Kingdom. In one Icelandic farm, flocks have been eradicated three times; each time, the farm was left without sheep for 2 years, and after restocking with sheep from scrapie-free areas, the disease reappeared. Several years ago, a suggestion was made (S Sigurdarson, personal communication) that hay mites would be a good candidate as a vector for scrapie; this led to infection of mice with mite samples prepared from hay obtained from five Icelandic farms. Ten of these 71 mice became sick after injection with mite preparations from three of the five farms (Wisniewski et al, 1996; Rubenstein et al, 1998). The incubation periods ranged from 340 days to 626 days, and these mice had the protease-resistant form Prp of a host-coded glycoprotein, PrP . The protease-resistant form is a marker of TSE disease (Prusiner, 1991; Parchi et al, 1996). For some of these clinically positive mice, the banding pattern on WB analysis was unique (Wisniewski et al, 1996; Rubenstein et al, 1998)."
Western blot
A western blot is also used as the definitive test for variant Creutzfeldt-Jakob Disease, a type of prion disease linked to the consumption of contaminated beef from cattle with Bovine spongiform encephalopathy (BSE, commonly referred to as 'mad cow disease').
Industrial Disease (song)
The reference to "Brewer's Droop" as a medical condition is an in-joke, referring both to the effect of alcohol on libido and to the band of the same name that Mark Knopfler played in prior to "Dire Straits".
Leukodystrophy
Like MLD, Krabbe disease is another type of leukodystrophy with autosomal recessive inheritance that is the result of a lysosomal storage disorder. It is due to a deletion in exon 16 of the GALC gene that causes a frameshift mutation leading to a premature stop codon. The GALC gene, found on chromosome 14 at position 31 (14q31), codes for the enzyme beta-galactocerebrosidase (GALC). GALC is a lysosomal enzyme responsible for the catabolism of galactolipids, especially psychosine, that are heavily distributed throughout the brain. A deficiency in GALC thus causes a buildup of these fatty acids known as “globoid” macrophages that destroy oligodendrocytes, thereby inhibiting myelin formation. Because of the presence of these globoid cells, clustered near white matter, Krabbe Disease often goes by the name Globoid Cell Leukodystrophy. Furthermore, new research has shown that Krabbe Disease and Globoid Cell Leukodystrophy may be distinct disease entities due to the secretion of inflammatory mediators by natural killer cells in some cases. This research has shown that Natural Killer cells have receptors (TDAG8) for certain glycosphingolipids that build up in an individual with leukodystrophy, again due to insufficient GALC levels, and when bound, target the Natural Killer cells for destruction thereby preventing their cytotoxic effects. These sphingolipids have been identified as galactosyl sphingosine and glycosyl sphingosine and are not present in unaffected individuals.
Michael Greger
He enrolled in Tufts University School of Medicine, originally for its MD/PhD program, but he withdrew from the dual-degree program to pursue only the medical degree. He graduated in 1999 as a general practitioner specializing in clinical nutrition. In 2001, he joined Organic Consumers Association to work on mad cow issues, on which he spoke widely as cases of mad cow appeared in the US and Canada, calling mad cow "The Plague of the 21st Century."
Scalped (comics)
Red Crow has unresolved romantic feelings for Gina Bad Horse, with whom he shares a history during their times as militant Native American rights activists. His estranged daughter Carol refuses to speak to him civilly, and he becomes concerned with Dashiell's obsession with her. As the series continues, his attempts at redemption are met with mixed results, idealism clashing against the cold reality of life on the Rez.
Mad in America
Physician J. van Gijn, reviewing the book for the "New England Journal of Medicine," writes that "the book is more of an indictment than a historical account," and starts by pointing out that Whitaker "virtually equates mental illness with schizophrenia; depression and other psychiatric disorders are mentioned only parenthetically." Van Gijn summarizes the pre-1950 coverage of the book without much commentary, but then criticizes the rest of the book. Specifically, he questions Whitaker's assertion that Kraepelin's schizophrenia patients in fact suffered from encephalitis lethargica. With regard to antipsychotic medication, van Gijn notes that "Although there may be truth in the notion that dosages of antipsychotic drugs in the United States are higher than necessary, the author weakens his position by issuing continuous and unrelenting condemnations (for instance, “The Nuremberg Code doesn't apply here”), despite a dearth of evidence to support them." Van Gijn then describes Whitaker's attack on the dopamine hypothesis of schizophrenia as "simplistic reasoning," and concludes that "Although [Whitaker] is widely read on the subject, the facts are largely arranged to suit his prejudice, especially in the chapters on drug treatment. American psychiatric institutions may have their failings in the current management of patients with schizophrenia, but they deserve better critics."
Pathogen
According to the prion theory, prions are infectious pathogens that do not contain nucleic acids. These abnormally folded proteins are found characteristically in some diseases such as scrapie, bovine spongiform encephalopathy (mad cow disease) and Creutzfeldt–Jakob disease.
Tha Blue Carpet Treatment
Nathan Rabin for "The A.V. Club" reviewed the album and wrote that "Snoop has always been able to knock out infectious radio singles, but his albums generally strand a few knockout songs amid oceans of lazy filler, opportunist trend-hopping, and derivative, second-rate G-funk. Sleepy, anticlimactic recent reunion albums from Dogg Pound and 213 (Snoop, Warren G, and Nate Dogg) failed to rouse Snoop out of his longstanding professional funk. So why does Snoop's shockingly good Tha Blue Carpet Treatment sound more like a loose, revitalized follow-up to Doggystyle? Dr. Dre's reappearance certainly doesn't hurt. Dre has always brought out the best in Snoop, and his presence seems to have reignited Snoop's passion and hunger. No track better exemplifies the disc's ethos of delirious excess than "Candy (Drippin' Like Water)", an insanely catchy candy-coated R&B song with clever nods to hyphy (E-40 and producer Rick Rock) and retro jazz-rap (check out that crazy Digable Planets sample!), plus guest raps from a small army of past-their-prime gangstas.
When faced with a choice, Snoop here inevitably chooses all of the above. So Treatment gives listeners Dr. Dre and The Neptunes, The Game and Ice Cube, red-hot polygamy enthusiast Akon and old standby Nate Dogg, George Clinton and Stevie Wonder, gangsta shit, pimp shit, and at least one song encouraging pee-wee football players to go hard or go home. With his lush Blue Carpet Treatment, Snoop Dogg finally seems intent on building and expanding his musical legacy, rather than merely coasting on it.
Classical swine fever
Classical swine fever (CSF) or hog cholera (also sometimes called pig plague based on the German word "Schweinepest") is a highly contagious disease of swine (Old World and New World pigs).
Stryker (1983 film)
The "Monthly Film Bulletin" gave the film a negative review, describing the film as "Workaday, predictable, edited to the bone, "Stryker" is very much a New World yarn. It cruises on automatic pilot from the first frame to the last." "Variety" described the film as a "Grade-D imitation of "The Road Warrior." "Stryker" offers little for today's action audience." The review described the Cohen's script as Howard R. Cohen's script as "insane" and leading man Steve Sandor as "ugly", and a "combination imitation of Indiana Jones and Mad Max" and that director Santiago's shots "rarely match, making for sloppy editing and enervating tedium." In Phil Hardy's book "Science Fiction" (1984), a review compared to other "Mad Max" derivatives, noting it was "even more ridiculous than its Italian competitor "I Nuovi Barbari" (1983)." and lamented that director Santiago "used to turn out at least halfway decent movies for Roger Corman's New World from his Filipino base including "Fly Me", "Savage!" (both 1973), "TNT Jackson" (1975) and the like."
Al Capp
Besides "Dick Tracy", Capp parodied many other comic strips in "Li'l Abner"—including "Steve Canyon", "Superman" (at least twice; first as "Jack Jawbreaker" in 1947, and again in 1966 as "Chickensouperman"), "Mary Worth" as "Mary Worm", "Peanuts" {with "Peewee" a parody of Charlie Brown with "Croopy" parody of Snoopy" {1968} drawn by Bedley Damp a parody of Charles Schulz}, "Rex Morgan, M.D.", "Little Annie Rooney" and "Little Orphan Annie" (in which Punjab became "Punjbag," an oleaginous slob). "Fearless Fosdick"—and Capp's other spoofs like "Little Fanny Gooney" (1952) and "Jack Jawbreaker"—were almost certainly an early inspiration for Harvey Kurtzman's "Mad Magazine", which began in 1952 as a comic book that specifically parodied other comics in the same distinctive style and subversive manner.
Foodborne illness
Serious outbreaks of foodborne illness since the 1970s prompted key changes in UK food safety law. These included the death of 19 patients in the Stanley Royd Hospital outbreak and the bovine spongiform encephalopathy (BSE, mad cow disease) outbreak identified in the 1980s. The death of 21 people in the 1996 Wishaw outbreak of "E. coli" O157 was a precursor to the establishment of the Food Standards Agency which, according to Tony Blair in the 1998 white paper "A Force for Change" Cm 3830, "would be powerful, open and dedicated to the interests of consumers".
WHO Disease Staging System for HIV Infection and Disease in Children
Cryptosporidiosis
Rocky Mountain elk
As of 2010, the Rocky Mountain elk herd has been diagnosed with a serious disorder called Chronic Wasting Disease (CWD). CWD affects the brain tissue of infected elk and is similar in symptoms to bovine spongiform encephalopathy (BSE), commonly known as mad-cow disease. There is no evidence to conclude that elk CWD is transmittable to humans, and research concerning CWD and its effect on the eco-system continues. Environmental and CWD problems in Estes Park, Colorado and, on a greater scale, throughout the Western U.S. and North America have local, state, and federal policy makers searching for solutions.
Scrapie
Out of fear of BSE, many European countries banned some traditional sheep or goat products made without removing the spinal cord, such as smalahove and smokie.
Pronoia (psychology)
In May 1994, "Wired" magazine published an article titled "Zippie!" The cover of the magazine featured a psychedelic image of a smiling young man with wild hair, a funny hat, and crazy eyeglasses. Written by Jules Marshall, the article announced an organized cultural response to Thatcherism in the United Kingdom. The opening paragraphs describe "a new and contagious cultural virus" and refer to pronoia as "the sneaking feeling one has that others are conspiring behind your back to help you".
The article announces a cultural and musical invasion of the United States to rival the British Invasion of 1964-1966, culminating with a "Woodstock Revival" to be staged at the Grand Canyon in August 1994. The spokesperson for the Zippies, Fraser Clark, dubs this movement the "Zippy Pronoia Tour". An article in "The New York Times" published in August 1994 also described the Zippies and their efforts. It contained two references to pronoia.
Scrapie
The prion gene that codes for the prion protein is highly conserved in most mammals, meaning the gene is similar and present in most species of mammals. Three locations on the prion protein gene have been identified as highly polymorphic and may have an effect on scrapie: codons 136, 154, and 171. Codon 154 has not shown any evidence of having a high effect on scrapie susceptibility, but is most likely having an effect on incubation time of the disease. Codons 136 and 171 are thought to control the incubation time as well as the susceptibility of the disease, and are the ones the USDA uses in its breeding standard. Codon 171 has been determined to be the major genetic factor in scrapie susceptibility.
Libba Bray
"Going Bovine" was published by Delacorte in 2009 and won the annual Michael L. Printz Award from the American Library Association recognizing literary excellence in young adult literature. It is a dark comedy about a 16-year-old boy named Cameron who has mad cow disease and a 16-year-old dwarf named Gonzo whom he met in the hospital. Gonzo is a video gamer who thinks that everything is trying to kill him. Cameron has visitation from a punkish angel named Dulcie who has a propensity for spray-painting her wings. They are all on a mission to cure Cameron's mad cow disease.
Medicine show
Several modern musical acts have named themselves after this old-time phenomenon, including Old Crow Medicine Show, Dr. West's Medicine Show and Junk Band, Moondog Medicine Show, Dr. Hook & The Medicine Show and MV & EE Medicine Show. The name was also used in the titles of The Dream Syndicate's album "Medicine Show", Big Audio Dynamite's song "Medicine Show", Moxy Früvous's song "The Incredible Medicine Show", and The Band's song "W.S. Walcott Medicine Show". Throughout 2010 and 2011, the hip hop artist Madlib released a 12-part mix series with the title "Madlib Medicine Show".
North Ronaldsay sheep
Modern DNA analysis has shown little crossbreeding with other sheep breeds from mainland Britain. Testing carried out under the National Scrapie Plan looked for the ARQ allele, which protects against the scrapie disease and is present in modern selectively bred sheep, and found it in only 1.3 per cent of North Ronaldsay sheep.
Stewie Griffin
In the more recent seasons, Stewie has a larger amount of freedom from his parents, usually spending much of his time with Brian. This extends to the point of him being able to keep pigs from parallel universes ("Road to the Multiverse") or take part in the television series "Jolly Farm" ("Go Stewie Go"), as compared to the first season, in which his plans were constantly hindered by Lois. In "The Hand That Rocks the Wheelchair", Stewie inadvertently clones an evil twin of himself after trying to increase his evil nature. By the end of the episode, it is suggested that the original Stewie may have been unknowingly killed by Brian (as he cannot tell them apart) and Stewie turns to the camera with glowing yellow eyes (reminiscent of Michael Jackson's "Thriller"). But so far, the Stewie recently seen in "Trading Places", the follow-up episode, he still seems to have his mostly harmless eccentricity, shown when he asks Brian if he wants to trade places with him for fun. He also starts to interact with more people despite still having hatred towards many of them, as shown in cutaways in later episodes, and more flamboyant. Stewie is shown in more recent episodes to be a superfan of Taylor Swift, and even sets her up with Chris as a Prom date. Stewie has had a few rare interactions with his apparent pedophile neighbor Herbert. Stewie intensely dislikes him and is one of the few characters fully aware of Herbert's nature, even calling him a pervert to his face. All this does, however, is move Herbert into thinking Stewie as "feisty".
West Highland White Terrier
The breed is predisposed to conditions found in many breeds, such as abdominal hernias. Westie puppies may be affected by craniomandibular osteopathy, a disease also known as "lion jaw", and is sometimes also referred to as "westie jaw". The disease is an autosomal recessive condition, so a puppy can only be affected by it if both its parents are carriers of the faulty gene. The condition appears across many breeds, including several different types of terriers, as well as other unrelated breeds such as the Great Dane. It typically appears in dogs under a year old, and can cause problems for the dog to chew or swallow food. Radiographic testing can be conducted to diagnose the condition, in which the bones around the jaw thicken; additionally, the blood may show increased calcium levels and enzyme levels. The condition often stops progressing by the time the dog is a year old, and in some cases can recede. It is normally treated with anti-inflammatory medications, and the feeding of soft foods. In some cases, tube feeding may be necessary. However, if the animal still cannot eat and is in uncontrolled pain, then euthanasia may be the only medical option remaining.
PRNP
The protein can exist in multiple isoforms, the normal PrP, and as protease-resistant PrP like the disease-causing PrP and an isoform located in mitochondria. The misfolded version PrP is associated with a variety of cognitive disorders and neurodegenerative diseases such as in animals: ovine scrapie, bovine spongiform encephalopathy, feline spongiform encephalopathy, transmissible mink encephalopathy, ungulate spongiform encephalopathy, chronic wasting disease which affects Cervidae; and in humans: Creutzfeldt–Jakob disease, fatal familial insomnia, Gerstmann–Sträussler–Scheinker syndrome, kuru, and variant Creutzfeldt–Jakob disease. Similarities exist between kuru disease, thought to be due to human ingestion of diseased individuals, and vCJD disease, thought to be due to human ingestion of BSE-tainted cattle products.
Zombo (comics)
His decomposed appearance aside, Zombo’s most pronounced zombie trait is his hunger for human flesh. In other respects, he is characterised as quite human and is especially polite. He is illustrated wearing a red codpiece like that worn by Larry Blackmon of Cameo in the music video for the single “Word Up!”. The codpiece works like a shock collar to ensure obedience. When he suffers serious physical trauma his body temporarily shuts down in emergency damage mode. After the first story he commands the death shadow as a weapon. He has the cloned brain of a stripper called Eric Rabinowicz in his buttocks to act as an emergency auxiliary brain.
Crash B-Daman
Jubee's pet crow. Like a dog, he can detect a person's location by their smell. His name seems to be a play on the Japanese pronunciation of the word "Crash" and the Japanese word for crow, "Karasu".
In the anime, he may seem like a kind-hearted and gentle teenager who takes cares of the children in the orphanage, but since he has a split personality, he can change his personality into an evil person who is trying to steal B-Damans, along with an evil laughter, known as "Devil B-Der". His split personality is often called the "angel" side and the "devil" side. He is often change personality when he is B-Dabattling or when his "angel" side got nauseous when riding boats. It was revealed that his real personality is his "angel" side. He was disqualified in the first round in B-1 Crash Cup because of his "devil" side cheating when battling with Jubee. In the World Crash Grandprix, he was defeated by Joe in the first round. Also participated in the East VS West B-Battle Festival in Hell Island, but as a part of the West village team instead. He didn't participate in the national B-1 Crash Cup, but appeared for a while around the tournament battling with Kodoh. After gained his true heart, he was the last to join Hitto as the Seven Legendary B-Ders to destroy the War Weapon by Saionji Konzern, and this surprises Nana a lot.
Johnny Cash
In 1997, Cash was diagnosed with the neurodegenerative disease Shy–Drager syndrome, a form of multiple system atrophy. According to biographer Robert Hilburn, the disease was originally misdiagnosed as Parkinson's disease, and Cash even announced to his audience that he had Parkinson's after nearly collapsing on stage in Flint, Michigan, on October 25, 1997. Soon afterwards, his diagnosis was changed to Shy–Drager, and Cash was told he had about 18 months to live. The diagnosis was later again altered to autonomic neuropathy associated with diabetes. The illness forced Cash to curtail his touring. He was hospitalized in 1998 with severe pneumonia, which damaged his lungs.
List of minor characters in Judge Dredd
He is a brilliant but strange maniac able to morph his face and body into every terror imaginable. He takes great delight in torturing those who come from the Mega City down into the Undercity who disturb his playground of horrors. On one occasion The Creep tortured a hunting party that descends to the Undercity. An example of his bizarre behaviour was transplanting the head of one of the members on to the neck of his pet crocodile Yorkie.
Scrapie
Exposure through contaminated hay mites
Daniel Carleton Gajdusek
Kuru was shown to have remarkable similarity to scrapie, a disease of sheep and goats caused by an unconventional infectious agent. Subsequently, additional human agents belonging to the same group were discovered. They include sporadic, familial, and variant Creutzfeldt–Jakob disease. Gajdusek recognized that diseases like Kuru and Creutzfeldt–Jakob disease were caused by a new infectious agent that had not yet been identified. Further research on the scrapie agent by Stanley Prusiner and others led to the identification of endogenous proteins called prions as the cause of these diseases.
Scrapie
Scrapie is infectious and transmissible among conspecifics, so one of the most common ways to contain it (since it is incurable) is to quarantine and destroy those affected. However, scrapie tends to persist in flocks and can also arise apparently spontaneously in flocks that have not previously had cases of the disease. The mechanism of transmission between animals and other aspects of the biology of the disease are only poorly understood, and these are active areas of research. Recent studies suggest prions may be spread through urine and persist in the environment for decades.
Krabbe disease
Krabbe disease may also be found in cats and in dogs, particularly the West Highland White Terrier and Cairn Terriers. The disease may also be found in dolphins."This article incorporates public domain text from the United States National Library of Medicine and the National Institute of Neurological Disorders and Stroke."
Scottish Terrier
Also known as "Lion Jaw", "Westy Jaw" or "Scotty Jaw", this condition of craniomandibular osteopathy is caused by excessive bone growth in the bottom jaw, usually occurring between four and seven months of age. Like Scottie Cramp, it is an autosomal recessive hereditary disorder, and can cause discomfort to the dog when it attempts to chew. The progression of the condition usually slows down between eleven and thirteen months of age, and is sometimes followed by a slow partial or complete regression.
Sphingolipidoses
Sphingolipidoses (singular "sphingolipidosis") are a class of lipid storage disorders relating to sphingolipid metabolism. The main members of this group are Niemann–Pick disease, Fabry disease, Krabbe disease, Gaucher disease, Tay–Sachs disease and metachromatic leukodystrophy. They are generally inherited in an autosomal recessive fashion, but notably Fabry disease is X-linked recessive. Taken together, sphingolipidoses have an incidence of approximately 1 in 10,000, but substantially more in certain populations such as Ashkenazi Jews. Enzyme replacement therapy is available to treat mainly Fabry disease and Gaucher disease, and people with these types of sphingolipidoses may live well into adulthood. The other types are generally fatal by age 1 to 5 years for infantile forms, but progression may be mild for juvenile- or adult-onset forms.
List of Itchy &amp; Scratchy episodes
Title pun "House M.D."
"Simpsons" episode: "Postcards from the Wedge"
Year: 2010
Synopsis: Scratchy comes to the clinic because of a sore paw. Itchy (with a beard reminiscent of that of Dr. House) first saws off his legs, then cuts out his heart, all with "Teardrop" playing in the background.
Cat skin disorders
Some systemic diseases can become symptomatic as a skin disorder. In cats this includes one of the most devastating cat skin disorders, feline acquired skin fragility syndrome, which can come from starvation or over-treatment with cortisone-like drugs or with diabetes, FIP or Cushings Disease.
Toxoplasmosis
"Crazy cat-lady syndrome" is a term coined by news organizations to describe scientific findings that link the parasite "Toxoplasma gondii" to several mental disorders and behavioral problems. Although researchers found that cat ownership does not strongly increase the risk of a "T. gondii" infection in pregnant women, the suspected correlation between cat ownership in childhood and later development of schizophrenia suggests that further studies are needed to determine a risk factor for children. The term "crazy cat-lady syndrome" draws on both stereotype and popular cultural reference. It was originated as instances of the aforementioned afflictions were noted amongst the populace. Cat lady is a cultural stereotype of a woman, often a spinster, who compulsively hoards and dotes upon cats. Jaroslav Flegr (biologist) is a proponent of the theory that toxoplasmosis affects human behaviour.Although "T. gondii" has the capability of infecting virtually all warm-blooded animals, susceptibility and rates of infection vary widely between different genera and species. Rates of infection in populations of the same species can also vary widely due to differences in location, diet, and other factors.
The Mad Pooper
At "Psychology Today", Dale Hartley, an associate professor of psychology at West Virginia University at Parkersburg, was dismissive of the idea that the Mad Pooper might suffer from an ailment that caused those problems, since she was so public in her defecations and had shown no sign of changing her routine to avoid having to do so. Nor did he think she had any psychosis, as she was "too put-together to be out of touch with reality" and kept to a regular schedule. "We would not expect to see consistently organized, predictable behaviors in someone who has undergone a psychotic break," Hartley wrote.
Dan Kroffat
After leaving wrestling in 1985, Kroffat opened Daniel's Auto Wholesale Centre, a used car dealership. After bovine spongiform encephalopathy, also known as mad cow disease, was discovered in an Albertan cow in 2003, the United States stopped importing Canadian cattle. Due to the problems this created in the Albertan cattle industry, Kroffat led a campaign to reopen the border, gathering signatures on a petition and pressuring the Canadian federal government to help with the cause.