Beekeeping
The queen is the only sexually mature female in the hive and all of the female worker bees and male drones are her offspring. The queen may live for up to three years or more and may be capable of laying half a million eggs or more in her lifetime. At the peak of the breeding season, late spring to summer, a good queen may be capable of laying 3,000 eggs in one day, more than her own body weight. This would be exceptional however; a prolific queen might peak at 2,000 eggs a day, but a more average queen might lay just 1,500 eggs per day. The queen is raised from a normal worker egg, but is fed a larger amount of royal jelly than a normal worker bee, resulting in a radically different growth and metamorphosis. The queen influences the colony by the production and dissemination of a variety of pheromones or "queen substances". One of these chemicals suppresses the development of ovaries in all the female worker bees in the hive and prevents them from laying eggs.
Nosema apis
"Nosema" spores are spread to other colony members through fecal matter. The disease impairs the digestion of pollen, thereby shortening the life of the bee. A greater proportion of worker bees become infected than drones or queens, probably due to the comb-cleaning activities of young bees in which drones and queens do not participate. "Nosema"-infected bees do not attend or feed the queen to the same extent as healthy bees, which helps the queen to escape infection. When the queen becomes infected, her ovaries degenerate and her egg-laying capacity is reduced due to atrophy of the oocytes. Queens that become infected by the parasite during the brood-rearing season are superseded by the bees.