Interstate 80
I-80 is the Interstate Highway that most closely approximates the route of the historic Lincoln Highway, the first road across the United States. The highway roughly traces other historically significant travel routes in the Western United States: the Oregon Trail across Wyoming and Nebraska, the California Trail across most of Nevada and California, the first transcontinental airmail route, and except in the Great Salt Lake area, the entire route of the First Transcontinental Railroad. From near Chicago east to near Youngstown, Ohio, I-80 is a toll road, containing the majority of both the Indiana Toll Road and the Ohio Turnpike. I-80 runs concurrently with I-90 from near Portage, Indiana, to Elyria, Ohio. In Pennsylvania, I-80 is known as the Keystone Shortway, a non-tolled freeway that crosses rural north-central portions of the state on the way to New Jersey and New York City.
Pocono Mountains
There are two U.S. Highways in the Pocono Mountains region. The most used is U.S. Route 209, which goes from Ulster, New York to Millersburg, Pennsylvania (near Harrisburg). The halfway point of the route is in the region north of Stroudsburg. The other main U.S. Highway in the region is U.S. Route 6, which is a transcontinental highway that starts near Bishop, California and runs for over 3,000 miles to its eastern terminus in Provincetown, Massachusetts. It is designated a scenic route in Pennsylvania. U.S. Route 11, U.S. Route 22, and U.S. Route 46 are also not far from the region and serve it indirectly.