Astemizole
Astemizole (marketed under the brand name Hismanal, developmental code R43512) was a second-generation antihistamine drug that has a long duration of action. Astemizole was discovered by Janssen Pharmaceutica in 1977. It has been withdrawn from the market in most countries because of rare but potentially fatal side effects (QTc interval prolongation and related arrhythmias due to hERG channel blockade).
Testosterone (medication)
A subsequent 2017 systematic review and meta-analysis of over 3,000 postmenopausal women similarly found that transdermal testosterone therapy was effective in improving multiple domains of sexual function in the short-term treatment of HSDD. Androgenic adverse effects such as acne and hirsutism were significantly greater in incidence, while no significant differences in "increase in facial hair, alopecia, voice deepening, urinary symptoms, breast pain, headache, site reaction to the patch, total adverse events, serious adverse events, reasons for withdrawal from the study, and the number of women who completed the study" were seen relative to the controls.