Endocrine gland
The adrenal glands are located above the kidneys in humans and in front of the kidneys in other animals. The adrenal glands produce a variety of hormones including adrenaline and the steroids aldosterone and cortisol. It controls the behaviour during crisis and emotional situations. It stimulates the heart and its conducting tissues and metabolic processes.
Adrenodoxin reductase
ADXR gene is expressed in all tissues that have mitochondrial P450s. The highest levels of the enzyme are found in the adrenal cortex, granulosa cells of the ovary and leydig cells of the testis that specialize in steroid hormone synthesis. Immmunofluorescent staining shows that enzyme is localized in mitochondria.
The enzyme is also expressed in the liver, the kidney and the placenta.