Phytophthora ramorum
Trials of silvicultural methods for treating "P. ramorum" began in Humboldt County in northwest coastal California in 2006. The trials have taken place on a variety of infested properties both private and public and have generally focused on varying levels and kinds of host removal. The largest () and most replicated trials have involved removal of tanoak and bay laurel by chainsaw throughout the infested stand, both with and without subsequent underburning designed to eliminate small seedlings and infested leaf litter. Other treatments included host removal in a modified “shaded fuelbreak” design in which all bay laurel is removed, but not all tanoaks; bay and tanoak removal using herbicides; and removal of bay laurel alone. The results of these treatments are still being monitored, but repeated sampling has so far detected only very small amounts of "P. ramorum" in the soil or on vegetation in the treated sites.
Phialophora verrucosa
Antifungal drugs like itraconazole and terbinafine are typically used to treat infections caused by "P. verrucosa". Amphotericin B, another antifungal drug, is only used occasionally, as it is cardiotoxic and is unsuitable for long-term therapy. While the spread of chromoblastomycosis to the muscle and bone is usually rare, in cases where antifungal drugs alone are insufficient in controlling the dissemination of the infection, limb amputation is required. Topical heat therapy, such as the use of disposable pocket warmers that sustain a temperature of 40 °C or greater for a period of 12 hours, as well as localized cryotherapy, may be effective in preventing the growth of "P. verrucosa" and treating lesions. "P. verrucosa" exhibits some resistance to antifungal drugs, and prescribed treatments often require a combination of antifungal drugs. The use of fluconazole, followed by the combined use of oral itraconazole and the topical application of copper sulphate solution, was reportedly successful in treating a phaehyphomycotic ulcer caused by "P. verrucosa". In vitro, different isolates of "P. verrucosa" respond differently to the same combinations of antifungal drugs. The combination of amphotericin B and terbinafine was observed to cause a synergistic effect for some isolates but cause no effect in others.