Lithium hydride
Before the Castle Bravo nuclear weapons test in 1954, it was thought that only the less common isotope lithium-6 would breed tritium when struck with fast neutrons. The Castle Bravo test showed (accidentally) that the more plentiful lithium-7 also does so under extreme conditions, albeit by an endothermic reaction.
Mark 24 nuclear bomb
The Castle Yankee thermonuclear test was the first bomb to use enriched Lithium-6 isotope, up to perhaps 40% enrichment (the earlier Castle Bravo test had used the same enriched lithium combination but was not weaponised i.e. was not built as a deployable bomb). The device tested was called the Runt II design; it was reportedly very similar to the Runt design tested in Castle Romeo, other than the enrichment level.