Lithium hydride
Before the Castle Bravo nuclear weapons test in 1954, it was thought that only the less common isotope lithium-6 would breed tritium when struck with fast neutrons. The Castle Bravo test showed (accidentally) that the more plentiful lithium-7 also does so under extreme conditions, albeit by an endothermic reaction.
History of nuclear weapons
In the beginning, almost all nuclear tests were either atmospheric (conducted above ground, in the atmosphere) or underwater (such as some of the tests done in the Marshall Islands). Testing was used as a sign of both national and technological strength, but also raised questions about the safety of the tests, which released nuclear fallout into the atmosphere (most dramatically with the Castle Bravo test in 1954, but in more limited amounts with almost all atmospheric nuclear testing).