Estradiol valerate
In addition to single-drug formulations, oral estradiol valerate is available in combination with the progestin dienogest as a combined oral contraceptive and intramuscular estradiol valerate is marketed in combination with the progestins hydroxyprogesterone caproate and norethisterone enantate as combined injectable contraceptives. Intramuscular estradiol valerate has also been marketed in combination with testosterone enantate, but this formulation has been discontinued. The availability of estradiol valerate-containing products varies throughout the world.
Estriol (medication)
Following its discovery in 1930, estriol was introduced for medical use as an oral tablet in the 1930s. Emmenin and Progynon were oral estrogens that contained estriol conjugates, primarily estriol glucuronide, and were introduced in the 1930s. They were the first orally active estrogen preparations to be introduced in medicine. Estriol continues to be used medically today, widely throughout the world and in a variety of different formulations and brand names.