Castle Bravo
Castle Bravo was the first in a series of high-yield thermonuclear weapon design tests conducted by the United States at Bikini Atoll, Marshall Islands, as part of "Operation Castle". Detonated on March 1, 1954, the device was the most powerful nuclear device detonated by the United States and its first lithium deuteride fueled thermonuclear weapon. Castle Bravo's yield was 15 megatons of TNT, 2.5 times the predicted 6.0 megatons, due to unforeseen additional reactions involving Li, which led to the unexpected radioactive contamination of areas to the east of Bikini Atoll.
Nuclear fusion
The latter of the two equations was unknown when the U.S. conducted the Castle Bravo fusion bomb test in 1954. Being just the second fusion bomb ever tested (and the first to use lithium), the designers of the Castle Bravo "Shrimp" had understood the usefulness of Li in tritium production, but had failed to recognize that Li fission would greatly increase the yield of the bomb. While Li has a small neutron cross-section for low neutron energies, it has a higher cross section above 5 MeV. The 15 Mt yield was 150% greater than the predicted 6 Mt and caused unexpected exposure to fallout.