Raphael
His mother Màgia died in 1491 when Raphael was eight, followed on August 1, 1494 by his father, who had already remarried. Raphael was thus orphaned at eleven; his formal guardian became his only paternal uncle Bartolomeo, a priest, who subsequently engaged in litigation with his stepmother. He probably continued to live with his stepmother when not staying as an apprentice with a master. He had already shown talent, according to Vasari, who says that Raphael had been "a great help to his father". A self-portrait drawing from his teenage years shows his precocity. His father's workshop continued and, probably together with his stepmother, Raphael evidently played a part in managing it from a very early age. In Urbino, he came into contact with the works of Paolo Uccello, previously the court painter (d. 1475), and Luca Signorelli, who until 1498 was based in nearby Città di Castello.
Raphaelle Peale
He married Martha (Patty) McGlathery at the age of twenty, and with her had eight children. For about two years beginning in 1803, Peale toured Virginia with the "physiognotrace", a profile making machine, with which he was briefly successful. By 1806 he had begun to suffer the symptoms of arsenic and mercury poisoning brought on by his work as a taxidermist in his father's museum. In August 1809 he was hospitalized with delirium, and for the rest of his life he suffered debilitating attacks almost yearly—which his father ascribed to "gout of the stomach" caused by consumption of pickles and excessive drinking. From 1810, Peale concentrated on still-life painting almost exclusively, becoming America's first professional still-life painter, and he exhibited frequently at the Pennsylvania Academy of the Fine Arts and elsewhere, especially from 1814–18. By 1813, he was unable to walk without crutches. After the downturn in his health, in an era when most artists considered still life a subject worthy only of amateurs, he devoted himself almost exclusively to still life painting. It is for these works he is best known. His work was on frequent exhibit at the Pennsylvania Academy of the Fine Arts between 1814 and 1818. After reportedly indulging in a night of heavy drinking, his health destroyed, he died on March 4, 1825, at age 51 at his home in Philadelphia.