Atomic mass
Any mass defect due to nuclear binding energy is experimentally a small fraction (less than 1%) of the mass of equal number of free nucleons. When compared to the average mass per nucleon in carbon-12, which is moderately strongly-bound compared with other atoms, the mass defect of binding for most atoms is an even smaller fraction of a dalton (unified atomic mass unit, based on carbon-12). Since free protons and neutrons differ from each other in mass by a small fraction of a dalton (about 0.0014 u), rounding the relative isotopic mass, or the atomic mass of any given nuclide given in daltons to the nearest whole number always gives the nucleon count, or mass number. Additionally, the neutron count (neutron number) may then be derived by subtracting the number of protons (atomic number) from the mass number (nucleon count).
Mass in special relativity
The term "mass" in special relativity usually refers to the rest mass of the object, which is the Newtonian mass as measured by an observer moving along with the object. The "invariant mass" is another name for the "rest mass" of single particles. The more general invariant mass (calculated with a more complicated formula) loosely corresponds to the "rest mass" of a "system". Thus, invariant mass is a natural unit of mass used for systems which are being viewed from their center of momentum frame (COM frame), as when any closed system (for example a bottle of hot gas) is weighed, which requires that the measurement be taken in the center of momentum frame where the system has no net momentum. Under such circumstances the invariant mass is equal to the relativistic mass (discussed below), which is the total energy of the system divided by "c" (the speed of light squared).