Cholera outbreaks and pandemics
That year, cholera was transmitted along the California, Mormon and Oregon Trails as 6,000 to 12,000 are believed to have died on their way to the California Gold Rush, Utah and Oregon in the cholera years of 1849–1855. It is believed more than 150,000 Americans died during the two pandemics between 1832 and 1849.
Oregon Trail
Though the numbers are significant in the context of the times, far more people chose to remain at home in the 31 states. Between 1840 and 1860, the population of the United States rose by 14 million, yet only about 300,000 decided to make the trip. Many were discouraged by the cost, effort and danger of the trip. Western scout Kit Carson is thought to have said, "The cowards never started and the weak died on the way", though the general saying was written by Joaquin Miller, in reference to the California gold rush. According to several sources, 3 to 10 percent of the emigrants are estimated to have perished on the way west.