Zeus
Zeus played a dominant role, presiding over the Greek Olympian pantheon. He fathered many of the heroes and was featured in many of their local cults. Though the Homeric "cloud collector" was the god of the sky and thunder like his Near-Eastern counterparts, he was also the supreme cultural artifact; in some senses, he was the embodiment of Greek religious beliefs and the archetypal Greek deity.
Hera (Marvel Comics)
She has appeared as the primary antagonist in "The Incredible Hercules". Following the death of Zeus, she inherits both his thunderbolt and the leadership of the Pantheon. In alliance with Pluto, she forcibly acquires Poseidon's stake in the Olympus corporation, and expels from the Pantheon all of Zeus' children holding a meeting with Apollo, Artemis, and Hephaestus, vowing to dedicate all her efforts to killing Hercules and Athena.