Microglia
Research has discovered dystrophic (defective development) human microglia. "These cells are characterized by abnormalities in their cytoplasmic structure, such as deramified, atrophic, fragmented or unusually tortuous processes, frequently bearing spheroidal or bulbous swellings." The incidence of dystrophic microglia increases with aging. Microglial degeneration and death have been reported in research on Prion disease, Schizophrenia and Alzheimer's disease, indicating that microglial deterioration might be involved in neurodegenerative diseases. A complication of this theory is the fact that it is difficult to distinguish between "activated" and "dystrophic" microglia in the human brain.
Carl Benda
Carl Benda (30 December 1857 Berlin – 24 May 1932 Turin) was one of the first microbiologists to use a microscope in studying the internal structure of cells. In an 1898 experiment using crystal violet as a specific stain, Benda first became aware of the existence of hundreds of these tiny bodies in the cytoplasm of eukaryotic cells and assumed that they reinforced the cell structure. Because of their tendency to form long chains, he coined the name "mitochondria" ("thread granules"). These bodies had first been noted in 1857 by the physiologist and pioneer of the light microscope, Albert von Kölliker, and were later termed "bioblasts" by Richard Altmann in 1886.