Raphael
His mother Màgia died in 1491 when Raphael was eight, followed on August 1, 1494 by his father, who had already remarried. Raphael was thus orphaned at eleven; his formal guardian became his only paternal uncle Bartolomeo, a priest, who subsequently engaged in litigation with his stepmother. He probably continued to live with his stepmother when not staying as an apprentice with a master. He had already shown talent, according to Vasari, who says that Raphael had been "a great help to his father". A self-portrait drawing from his teenage years shows his precocity. His father's workshop continued and, probably together with his stepmother, Raphael evidently played a part in managing it from a very early age. In Urbino, he came into contact with the works of Paolo Uccello, previously the court painter (d. 1475), and Luca Signorelli, who until 1498 was based in nearby Città di Castello.
Ralph Raphael
Ralph Raphael was born in Croydon, London on New Year's Day 1921, the son of Jack Raphael and his wife, Lily Woolfe. He attended secondary school at Wesley College, Dublin and then Tottenham County School, where a chemistry master, Edgar Ware, introduced him to the subject that would become Raphael's lifetime passion. In 1939 he won scholarships to study at Imperial College, graduating BSc with a first-class degree in 1941 and winning the Hofmann Prize for practical chemistry.
During the Second World War both the undergraduate and PhD courses at Imperial College were of two year's duration and Raphael completed the latter in 1943. His doctoral work, aimed at the synthesis of vitamin A, was published in five collaborative papers on the chemistry of acetylenes and that topic became a hallmark of his subsequent research career.