Lawrence, Kansas
Prior to Kansas Territory being established in May 1854, most of Douglas County was part of the Shawnee Indian Reservation (created in 1830). During this period, the Oregon Trail ran parallel to the Kansas River, roughly through the area where Lawrence would eventually be situated and a hill known then as "Hogback Ridge" (i.e., Mount Oread, which sits on the water divide separating the Kansas and Wakarusa River). This area was used as a landmark and an outlook by those on the trail. While this territory was technically unopened to settlement prior to 1854, there did exist a few "squatter settlements" in the area, especially just north of the Kansas River.
Eudora, Kansas
In 1854 the Kansas-Nebraska Act was passed, creating the Kansas Territory and opening the region to settlement by Americans. As a result of the Kansas-Nebraska Act, Americans settlers started to encroach upon Indian lands. In 1856, three members of a German Immigrant Settlement Company (called Deutsche-Neusiedlungsverein) from Chicago, sent out a location committee to choose a town site in the new Kansas Territory. Favoring the Eudora area, they drew up contracts with Shawnee Chief Paschal Fish, the original owner of the town site. The new town was named Eudora in honor of Chief Fish's daughter. The first post office in Eudora was established in September, 1857. Eudora was incorporated in 1859.