Silk
Silk moths lay eggs on specially prepared paper. The eggs hatch and the caterpillars (silkworms) are fed fresh mulberry leaves. After about 35 days and 4 moltings, the caterpillars are 10,000 times heavier than when hatched and are ready to begin spinning a cocoon. A straw frame is placed over the tray of caterpillars, and each caterpillar begins spinning a cocoon by moving its head in a pattern. Two glands produce liquid silk and force it through openings in the head called spinnerets. Liquid silk is coated in sericin, a water-soluble protective gum, and solidifies on contact with the air. Within 2–3 days, the caterpillar spins about 1 mile of filament and is completely encased in a cocoon. The silk farmers then heat the cocoons to kill them, leaving some to metamorphose into moths to breed the next generation of caterpillars. Harvested cocoons are then soaked in boiling water to soften the sericin holding the silk fibers together in a cocoon shape. The fibers are then unwound to produce a continuous thread. Since a single thread is too fine and fragile for commercial use, anywhere from three to ten strands are spun together to form a single thread of silk.
Silk
Silks derived from "Bombyx mori" are generally made of two parts: the silk fibroin fiber which contains a light chain of 25kDa and a heavy chain of 350kDa (or 390kDa) linked by a single disulfide bond and a glue-like protein, sericin, comprising 25 to 30 percentage by weight. Silk fibroin contains hydrophobic beta sheet blocks, interrupted by small hydrophilic groups. And the beta-sheets contribute much to the high mechanical strength of silk fibers, which achieves 740 MPa, tens of times that of poly(lactic acid) and hundreds of times that of collagen. This impressive mechanical strength has made silk fibroin very competitive for applications in biomaterials. Indeed, silk fibers have found their way into tendon tissue engineering, where mechanical properties matter greatly. In addition, mechanical properties of silks from various kinds of silkworms vary widely, which provides more choices for their use in tissue engineering.