Kennedy Space Center
On February 1, 2003, "Columbia" and her crew of seven were lost during re-entry over Texas during the STS-107 mission (the 113th shuttle flight); a vehicle breakup triggered by damage sustained during launch from Pad 39A on January 16, when a piece of foam insulation from the orbiter's external fuel tank struck the orbiter's left wing. During reentry, the damage created a hole allowing hot gases to melt the wing structure. Like the "Challenger" disaster, the resulting investigation and modifications interrupted shuttle flight operations at KSC for more than two years until the STS-114 launch on July 26, 2005.
STS-118
This was the first flight of "Endeavour" since STS-113 in November 2002, which was also the last successful shuttle flight before STS-107 which culminated in the loss of "Columbia" when it disintegrated during reentry. STS-118 pilot Charles Hobaugh had been the entry team CAPCOM for STS-107. "Columbia" would have been chosen for this mission, for what would have been its 29th mission, and its first and likely its only mission to the ISS.