Lawrence, Kansas
Prior to Kansas Territory being established in May 1854, most of Douglas County was part of the Shawnee Indian Reservation (created in 1830). During this period, the Oregon Trail ran parallel to the Kansas River, roughly through the area where Lawrence would eventually be situated and a hill known then as "Hogback Ridge" (i.e., Mount Oread, which sits on the water divide separating the Kansas and Wakarusa River). This area was used as a landmark and an outlook by those on the trail. While this territory was technically unopened to settlement prior to 1854, there did exist a few "squatter settlements" in the area, especially just north of the Kansas River.
History of the Kansas City metropolitan area
At the time of the City of Kansas's incorporation, Missouri was still a slave state. However, the population was deeply divided over the issue of slavery. In 1854, the United States Congress passed the Kansas-Nebraska Act, which rejected the 1820 Missouri Compromise and allowed new territories to choose whether they wished to allow slavery, whereas the Missouri Compromise had prohibited slavery in any new states to be created north of latitude 36°30'. Thus, according to the Missouri Compromise, Kansas Territory (located immediately to the west of the City of Kansas, Missouri) had been a free territory but now could choose to permit slavery.