Marie de Coucy
Alexander II died on 8 July 1249 during an expedition against the Lord of Argyll on the island of Kerrera. Immediately after the news reached her, Marie made sure her 8-year-old son was crowned as soon as possible at Scone. Although her son was a minor and was placed under regency, Marie did not become regent. On 9 June 1250 Marie and her son Alexander III were present in Dunfermline for the observance of the canonisation of Saint Margaret of Scotland and the transference of her remains to the new shrine.
Nicholas II of Russia
Further complicating domestic matters was the matter of the succession. Alexandra bore Nicholas four daughters, the Grand Duchess Olga in 1895, the Grand Duchess Tatiana in 1897, Grand Duchess Maria in 1899, and Grand Duchess Anastasia in 1901, before their son Alexei was born on 12 August 1904. The young heir was afflicted with Haemophilia B, a hereditary disease that prevents blood from clotting properly, which at that time was untreatable and usually led to an untimely death. As a granddaughter of Queen Victoria, Alexandra carried the same gene mutation that afflicted several of the major European royal houses, such as Prussia and Spain. Hemophilia therefore became known as "the royal disease". Through Alexandra the disease had passed on to her son. As all of Nicholas and Alexandra's daughters perished with their parents and brother in Yekaterinburg in 1918, it is not known whether any of them inherited the gene as carriers.