Strange quark
The first strange particle (a particle containing a strange quark) was discovered in 1947 (kaons), but the existence of the strange quark itself (and that of the up and down quarks) was only postulated in 1964 by Murray Gell-Mann and George Zweig to explain the Eightfold Way classification scheme of hadrons. The first evidence for the existence of quarks came in 1968, in deep inelastic scattering experiments at the Stanford Linear Accelerator Center. These experiments confirmed the existence of up and down quarks, and by extension, strange quarks, as they were required to explain the Eightfold Way.
Electron scattering
Stanford Linear Accelerator Center is located near Stanford University, California. Construction began on the 2 mile long linear accelerator in 1962 and was completed in 1967, and in 1968 the first experimental evidence of quarks was discovered resulting in the 1990 Nobel Prize in Physics, shared by SLAC's Richard Taylor and Jerome I. Friedman and Henry Kendall of MIT. The accelerator came with a 20GeV capacity for the electron acceleration, and while similar to Rutherford's scattering experiment, that experiment operated with alpha particles at only 7MeV. In the SLAC case the incident particle was an electron and the target a proton, and due to the short wavelength of the electron (due to its high energy and momentum) it was able to probe into the proton.
The Stanford Positron Electron Asymmetric Ring (SPEAR) addition to the SLAC made further such discoveries possible, leading to the discovery in 1974 of the J/psi particle, which consists of a paired charm quark and anti-charm quark, and another Nobel Prize in Physics in 1976.
This was followed up with Martin Perl's announcement of the discovery of the tau lepton, for which he shared the 1995 Nobel Prize in Physics.