Interstate 80
I-80 is the Interstate Highway that most closely approximates the route of the historic Lincoln Highway, the first road across the United States. The highway roughly traces other historically significant travel routes in the Western United States: the Oregon Trail across Wyoming and Nebraska, the California Trail across most of Nevada and California, the first transcontinental airmail route, and except in the Great Salt Lake area, the entire route of the First Transcontinental Railroad. From near Chicago east to near Youngstown, Ohio, I-80 is a toll road, containing the majority of both the Indiana Toll Road and the Ohio Turnpike. I-80 runs concurrently with I-90 from near Portage, Indiana, to Elyria, Ohio. In Pennsylvania, I-80 is known as the Keystone Shortway, a non-tolled freeway that crosses rural north-central portions of the state on the way to New Jersey and New York City.
U.S. Route 52 in West Virginia
U.S. Route 52 (US 52) skirts the western fringes of the U.S. state of West Virginia. It runs from the Virginia state line near Bluefield, where it is concurrent with Interstate 77 (I-77), in a general northwest and north direction to I-64 at Kenova. There it turns east, overlapping I-64 for before splitting off onto the West Huntington Expressway into Ohio via the West Huntington Bridge. Despite having an even number, US 52 is signed north–south in West Virginia. In some other states along its route, it is signed east-west. The West Virginia segment is signed such that US 52 north corresponds to the general westward direction of the highway, and vice versa. For a while, US 52 parallels US 23, which is on the other side of the Big Sandy River in Kentucky. This continues into Ohio, where US 52 travels on the Ohio side of the Ohio River while US 23 travels on the Kentucky side.