Cholera outbreaks and pandemics
That year, cholera was transmitted along the California, Mormon and Oregon Trails as 6,000 to 12,000 are believed to have died on their way to the California Gold Rush, Utah and Oregon in the cholera years of 1849–1855. It is believed more than 150,000 Americans died during the two pandemics between 1832 and 1849.
Oregon Trail
From the early to mid-1830s (and particularly through the years 1846–69) the Oregon Trail and its many offshoots were used by about 400,000 settlers, farmers, miners, ranchers, and business owners and their families. The eastern half of the trail was also used by travelers on the California Trail (from 1843), Mormon Trail (from 1847), and Bozeman Trail (from 1863), before turning off to their separate destinations. Use of the trail declined as the first transcontinental railroad was completed in 1869, making the trip west substantially faster, cheaper, and safer. Today, modern highways, such as Interstate 80 and Interstate 84, follow parts of the same course westward and pass through towns originally established to serve those using the Oregon Trail.