Interstate 80
I-80 is the Interstate Highway that most closely approximates the route of the historic Lincoln Highway, the first road across the United States. The highway roughly traces other historically significant travel routes in the Western United States: the Oregon Trail across Wyoming and Nebraska, the California Trail across most of Nevada and California, the first transcontinental airmail route, and except in the Great Salt Lake area, the entire route of the First Transcontinental Railroad. From near Chicago east to near Youngstown, Ohio, I-80 is a toll road, containing the majority of both the Indiana Toll Road and the Ohio Turnpike. I-80 runs concurrently with I-90 from near Portage, Indiana, to Elyria, Ohio. In Pennsylvania, I-80 is known as the Keystone Shortway, a non-tolled freeway that crosses rural north-central portions of the state on the way to New Jersey and New York City.
U.S. Route 301
According to one source, US 301 had been known as "Tobacco Trail" prior to its renaming in 1960 to "The Miss Universe Highway".
Prior to 2019, US 301 in Delaware started at the intersection of U.S. 40 and Delaware Route 896 in Glasgow. The highway was cosigned with DE 896, picking up Delaware Route 71 only three miles south of U.S. 40. Running parallel to US 13 and Delaware Route 1, the highway crossed the Chesapeake and Delaware Canal on the four-lane Summit Bridge. At Mount Pleasant, DE 896 headed east to intersect U.S. 13 at Boyd's Corner, while DE 71 continued to be cosigned with U.S. 301 until the road reached Middletown. U.S. 301 continued alone until it picked up two other roads, Delaware Route 15 and Delaware Route 299, which followed the highway to near the Maryland state line. On November 14, 2006, the Delaware Department of Transportation (DelDOT) announced that a new four-lane bypass around Middletown will reroute US 301 west of Middletown, with the road directly connecting to DE 1 in Biddles Corner. This bypass opened to traffic on January 10, 2019.