Fermi Paradox (album)
Fermi Paradox is the 2002 (see 2002 in music) album by the band Tub Ring named after Enrico Fermi's Fermi Paradox.
Manifold Trilogy
Each one of the main novels deals with a possible resolution to the Fermi paradox. The first, "Time", is set in a universe that is completely devoid of intelligent life beyond that of mankind and its creations (i.e. A.I. and uplifted animals).