Quark
The quark model was independently proposed by physicists Murray Gell-Mann and George Zweig in 1964. Quarks were introduced as parts of an ordering scheme for hadrons, and there was little evidence for their physical existence until deep inelastic scattering experiments at the Stanford Linear Accelerator Center in 1968. Accelerator experiments have provided evidence for all six flavors. The top quark, first observed at Fermilab in 1995, was the last to be discovered.
Electron scattering
Stanford Linear Accelerator Center is located near Stanford University, California. Construction began on the 2 mile long linear accelerator in 1962 and was completed in 1967, and in 1968 the first experimental evidence of quarks was discovered resulting in the 1990 Nobel Prize in Physics, shared by SLAC's Richard Taylor and Jerome I. Friedman and Henry Kendall of MIT. The accelerator came with a 20GeV capacity for the electron acceleration, and while similar to Rutherford's scattering experiment, that experiment operated with alpha particles at only 7MeV. In the SLAC case the incident particle was an electron and the target a proton, and due to the short wavelength of the electron (due to its high energy and momentum) it was able to probe into the proton.
The Stanford Positron Electron Asymmetric Ring (SPEAR) addition to the SLAC made further such discoveries possible, leading to the discovery in 1974 of the J/psi particle, which consists of a paired charm quark and anti-charm quark, and another Nobel Prize in Physics in 1976.
This was followed up with Martin Perl's announcement of the discovery of the tau lepton, for which he shared the 1995 Nobel Prize in Physics.