Microglia
The ability to view and characterize different neural cells including microglia began in 1880 when Nissl staining was developed by Franz Nissl. Franz Nissl and F. Robertson first described microglial cells during their histology experiments. The cell staining techniques in the 1880s showed that microglia are related to macrophages. The activation of microglia and formation of ramified microglial clusters was first noted by Victor Babeş while studying a rabies case in 1897. Babeş noted the cells were found in a variety of viral brain infections but did not know what the clusters of microglia he saw were. Pío del Río Hortega, a student of Santiago Ramón y Cajal, first called the cells "microglia" around 1920. He went on to characterize microglial response to brain lesions in 1927 and note the "fountains of microglia" present in the corpus callosum and other perinatal white matter areas in 1932. After many years of research Rio-Hortega became generally considered as the "Father of Microglia." For a long period of time little improvement was made in our knowledge of microglia. Then, in 1988, Hickey and Kimura showed that perivascular microglial cells are bone-marrow derived, and express high levels of MHC class II proteins used for antigen presentation. This confirmed Pio Del Rio-Hortega's postulate that microglial cells functioned similarly to macrophages by performing phagocytosis and antigen presentation.
Christopher Hills
Hills and Nakamura had a vision of feeding the world from lakes, seas and backyard aquaculture and in 1975 they authored a book, "Food from Sunlight" which published all their proprietary research as open source for the world to use in the cause against global famine and malnutrition. Their company, Microalgae International, invested in research and technology to find a super food for solving World Hunger. Early research focused on chlorella but its cellular structure was too small to be collected without expensive centrifuges. However, in 1967, while Dr Nakamura was living at Centre House, they discovered that women at Lake Chad were harvesting an algae in baskets to make dihé, a highly nutritious sun-baked biscuit. After studying the lakes of Africa, Hills and Dr Nakamura developed seed culture for a strain of 70% protein algae called spirulina that they had collected from Lake Aranguachi in Ethiopia. Later, in 1981, Dr Hills made an expedition to Lake Chiltu at the invitation of Mr. Wollie Chekal, Minister of Trade for the Ethiopian Revolutionary Government and brought back a new set of spirulina samples to his California laboratory for hybridizing an optimal strain for commercial cultivation.