Gastric acid
The main constituent of gastric acid is hydrochloric acid which is produced by parietal cells (also called oxyntic cells) in the gastric glands in the stomach. Its secretion is a complex and relatively energetically expensive process. Parietal cells contain an extensive secretory network (called canaliculi) from which the hydrochloric acid is secreted into the lumen of the stomach. The pH of gastric acid is 1.5 to 3.5 in the human stomach lumen, the acidity being maintained by the proton pump H/K ATPase. The parietal cell releases bicarbonate into the bloodstream in the process, which causes a temporary rise of pH in the blood, known as an alkaline tide.
Hammett acidity function
where "a" is the activity, and the γ are thermodynamic activity coefficients. In dilute aqueous solution (pH 0-14) the predominant acid species is HO and the activity coefficients are close to unity, so H is approximately equal to the pH. However beyond this pH range, the effective hydrogen-ion activity changes much more rapidly than the concentration. This is often due to changes in the nature of the acid species; for example in concentrated sulfuric acid, the predominant acid species ("H+") is not HO but rather HSO which is a much stronger acid. The value H = -12 for pure sulfuric acid must not be interpreted as pH = -12 (which would imply an impossibly high HO concentration of 10 mol/L in ideal solution). Instead it means that the acid species present (HSO) has a protonating ability equivalent to HO at a fictitious (ideal) concentration of 10 mol/L, as measured by its ability to protonate weak bases.