Mitochondrial matrix
The cytosolic, intermembrane space, compartment has a water content of 3.8 μl/mg protein, while the mitochondrial matrix 0.8 μl/mg protein. It is not known how mitochondria maintain osmotic balance across the inner mitochondrial membrane, although the membrane contains aquaporins that are believed to be conduits for regulated water transport. Mitochondrial matrix has a pH of about 7.8. Mitochondrial DNA was discovered by Nash and Margit in 1963. One to many double stranded mainly circular DNA is present in mitochondrial matrix. Mitochondrial DNA is 1% of total DNA of a cell. It is rich in Guanine and Cytosine content. Mitochondria of mammals have 55s ribosomes.
P. Michael Conneally
P. Michael Conneally, Ph.D., (December 4, 1931 – February 17, 2017) was the Distinguished Professor Emeritus at the Indiana University School of Medicine in the Department of Medical and Molecular Genetics. He was certified in medical genetics by the American Board of Medical Genetics and a founding fellow of the American College of Medical Genetics. He was a human geneticist interested in discovering the location of human genes that cause disease, specifically the mapping of Mendelian and complex inherited diseases including the study of Huntington's disease, genetics of alcoholism, diabetes and manic depressive illness. In collaboration with researchers from Columbia University and James F. Gusella of Harvard University, he was the first to use DNA techniques to map a human gene. In the past twenty years he has helped map approximately 20 human genes and his work has resulted in the identification of 20% of the human genome. Conneally received his bachelor's degree in Agriculture with Honors from University College Dublin in 1954 and Master’s and Ph.D. from the University of Wisconsin, Madison.