Estradiol (medication)
Estradiol is also available in the U.S. in combination with progestogens for the treatment of menopausal symptoms and as a combined hormonal contraceptive:Estradiol and estradiol esters are also available in custom preparations from compounding pharmacies in the U.S. This includes subcutaneous pellet implants, which are not available in the United States as FDA-approved pharmaceutical drugs. In addition, topical creams that contain estradiol are generally regulated as cosmetics rather than as drugs in the U.S. and hence are also sold over-the-counter and may be purchased without a prescription on the Internet.
Pharmacokinetics of progesterone
Progesterone does not appear to be available pharmaceutically in the form of subcutaneous pellet implants. This is in contrast to estradiol and testosterone. Progesterone may be available in the form of subcutaneous pellet implants from some compounding pharmacies however. Such products are not regulated for quality or effectiveness however. Subcutaneous implantation of progesterone has been studied in animals. Although progesterone is not available for subcutaneous implantation as a pharmaceutical product, subcutaneous implants of progestins, such as etonogestrel (Implanon/Nexplanon) and levonorgestrel (Jadelle/Norplant), are available as pharmaceutical preparations. They are used specifically as a form of long-lasting hormonal birth control.