Thyroid hormones
The thyroid hormones function via a well-studied set of nuclear receptors, termed the thyroid hormone receptors. These receptors, together with corepressor molecules, bind DNA regions called thyroid hormone response elements (TREs) near genes. This receptor-corepressor-DNA complex can block gene transcription. Triiodothyronine (T3), which is the active form of thyroxine(T4), goes on to bind to receptors. The deiodinase catalyzed reaction removes an iodine atom from the 5' position of the outer aromatic ring of Thyroxine's (T4) structure. When triiodothyronine (T3) binds a receptor, it induces a conformational change in the receptor, displacing the corepressor from the complex. This leads to recruitment of coactivator proteins and RNA polymerase, activating transcription of the gene.
Plastic pollution
Bisphenol A affects gene expression related to the thyroid hormone axis, which affects biological functions such as metabolism and development. BPA can decrease thyroid hormone receptor (TR) activity by increasing TR transcriptional corepressor activity. This then decreases the level of thyroid hormone binding proteins that bind to triiodothyronine. By affecting the thyroid hormone axis, BPA expoure can lead to hypothyroidism.