Cholera outbreaks and pandemics
That year, cholera was transmitted along the California, Mormon and Oregon Trails as 6,000 to 12,000 are believed to have died on their way to the California Gold Rush, Utah and Oregon in the cholera years of 1849–1855. It is believed more than 150,000 Americans died during the two pandemics between 1832 and 1849.
The Oregon Trail (1985 video game)
Throughout the course of the game, members of the player's party can fall ill and not rest, which causes further harm to the victim. The party can die from various causes and diseases, such as measles, snakebite, exhaustion, typhoid, cholera, and dysentery, as well as from drowning or accidental gunshot wounds. The player's oxen are also subject to injury and death.