Strange quark
The first strange particle (a particle containing a strange quark) was discovered in 1947 (kaons), but the existence of the strange quark itself (and that of the up and down quarks) was only postulated in 1964 by Murray Gell-Mann and George Zweig to explain the Eightfold Way classification scheme of hadrons. The first evidence for the existence of quarks came in 1968, in deep inelastic scattering experiments at the Stanford Linear Accelerator Center. These experiments confirmed the existence of up and down quarks, and by extension, strange quarks, as they were required to explain the Eightfold Way.
Fundamental interaction
Murray Gell-Mann along with George Zweig first proposed fractionally charged quarks in 1961. Throughout the 1960s, different authors considered theories similar to the modern fundamental theory of quantum chromodynamics (QCD) as simple models for the interactions of quarks. The first to hypothesize the gluons of QCD were Moo-Young Han and Yoichiro Nambu, who introduced the quark color charge and hypothesized that it might be associated with a force-carrying field. At that time, however, it was difficult to see how such a model could permanently confine quarks. Han and Nambu also assigned each quark color an integer electrical charge, so that the quarks were fractionally charged only on average, and they did not expect the quarks in their model to be permanently confined.