Strange quark
The first strange particle (a particle containing a strange quark) was discovered in 1947 (kaons), but the existence of the strange quark itself (and that of the up and down quarks) was only postulated in 1964 by Murray Gell-Mann and George Zweig to explain the Eightfold Way classification scheme of hadrons. The first evidence for the existence of quarks came in 1968, in deep inelastic scattering experiments at the Stanford Linear Accelerator Center. These experiments confirmed the existence of up and down quarks, and by extension, strange quarks, as they were required to explain the Eightfold Way.
Sheldon Lee Glashow
In collaboration with James Bjorken, Glashow was the first to predict a fourth quark, the charm quark, in 1964. This was at a time when 4 leptons had been discovered but only 3 quarks proposed. The development of their work in 1970, the GIM mechanism showed that the two quark pairs: (d.s), (u,c), would largely cancel out flavor changing neutral currents, which had been observed experimentally at far lower levels than theoretically predicted on the basis of 3 quarks only. The prediction of the charm quark also removed a technical disaster for any quantum field theory with unequal numbers of quarks and leptons — an anomaly — where classical field theory symmetries fail to carry over into the quantum theory.