Adrenal gland
The adrenal glands are named for their location relative to the kidneys. The term "adrenal" comes from "ad-" (Latin, "near") and "renes" (Latin, "kidney"). Similarly, "suprarenal", as termed by Jean Riolan the Younger in 1629, is derived from the Latin "supra" () and "renes" (). The suprarenal nature of the glands was not truly accepted until the 19th century, as anatomists clarified the ductless nature of the glands and their likely secretory role – prior to this, there was some debate as to whether the glands were indeed suprarenal or part of the kidney.
Kisspeptin
Kisspeptin and its receptor was found in various sites in the kidney, including in the collecting duct, vascular smooth muscle, and in the renal tubule cells. Much of the impact on the kidney deals with the increased production of aldosterone in the adrenals glands stimulated by kisspeptin. Kisspeptin directly increases release of aldosterone by several means, the first being through these receptors leading to a direct route to aldosterone release. Secondly, the H295R adrenal cells stimulated by kisspeptin can synthesize aldosterone by breaking down pregnenolone more efficiently. Lastly, the kisspeptin-angiotensin II pathway of producing aldosterone is increased. Aldosterone that comes from the neighboring adrenal glands causes reabsorption of filtrate in order to retain water, leading to an increased blood pressure.