Lawrence, Kansas
Prior to Kansas Territory being established in May 1854, most of Douglas County was part of the Shawnee Indian Reservation (created in 1830). During this period, the Oregon Trail ran parallel to the Kansas River, roughly through the area where Lawrence would eventually be situated and a hill known then as "Hogback Ridge" (i.e., Mount Oread, which sits on the water divide separating the Kansas and Wakarusa River). This area was used as a landmark and an outlook by those on the trail. While this territory was technically unopened to settlement prior to 1854, there did exist a few "squatter settlements" in the area, especially just north of the Kansas River.
Great Bend, Kansas
Prior to American settlement of the area, the site of Great Bend was located in the northern reaches of Kiowa territory. Claimed first by France as part of Louisiana and later acquired by the United States with the Louisiana Purchase in 1803, it lay within the area organized by the U.S. as Kansas Territory in 1854. Kansas became a state in 1861, and the state government delineated the surrounding area as Barton County in 1867.