Estradiol stearate
Estradiol stearate (brand name Depofollan), or estradiol octadecanoate, is a naturally occurring steroidal estrogen and an estrogen ester – specifically, the C17β stearate ester of estradiol. It occurs in the body as a very long-lasting metabolite and prohormone of estradiol. In addition, estradiol stearate is or has been available as a pharmaceutical drug for use via depot intramuscular injection. The drug was introduced in 1941 as Depofollan and was the first long-acting estrogen, although it has never been widely used. It has been reported in at least one source to have a duration of at least one month.
Ethinylestradiol
EE has been marketed as a standalone oral drug under the brand names "Esteed", "Estinyl", "Feminone", "Lynoral", "Menolyn", "Novestrol", "Palonyl", "Spanestrin", and "Ylestrol" among others, although most or all of these formulations are now discontinued. It is marketed under a very large number of brand names throughout the world in combination with progestins for use as an oral contraceptive. In addition, EE is marketed in the in combination with norelgestromin under the brand names "Ortho Evra" and "Xulane" as a contraceptive patch, in combination with etonogestrel under the brand name "NuvaRing" as a contraceptive vaginal ring, and in combination with norethisterone acetate under the brand name "FemHRT" in oral hormone replacement therapy for the treatment of menopausal symptoms.