Estradiol valerate
In addition to single-drug formulations, oral estradiol valerate is available in combination with the progestin dienogest as a combined oral contraceptive and intramuscular estradiol valerate is marketed in combination with the progestins hydroxyprogesterone caproate and norethisterone enantate as combined injectable contraceptives. Intramuscular estradiol valerate has also been marketed in combination with testosterone enantate, but this formulation has been discontinued. The availability of estradiol valerate-containing products varies throughout the world.
Estetrol (medication)
In addition to a single-drug formulation, estetrol is under development in combination with the progestin drospirenone for use as a birth control pill to prevent pregnancy with the tentative brand name Estelle. Drospirenone is also a potent antimineralocorticoid and antiandrogen in addition to progestogen, and in relation to this, is said to have a progesterone-like medication profile. As of April 2018, estetrol/drospirenone are in phase III clinical trials for pregnancy prevention.