Lithium hydride
Before the Castle Bravo nuclear weapons test in 1954, it was thought that only the less common isotope lithium-6 would breed tritium when struck with fast neutrons. The Castle Bravo test showed (accidentally) that the more plentiful lithium-7 also does so under extreme conditions, albeit by an endothermic reaction.
Castle Bravo
This resultant extra fuel (both lithium-6 and lithium-7) contributed greatly to the fusion reactions and neutron production and in this manner greatly increased the device's explosive output. The test used lithium with a high percentage of lithium-7 only because lithium-6 was then scarce and expensive; the later "Castle Union" test used almost pure lithium-6. Had sufficient lithium-6 been available, the usability of the common lithium-7 might not have been discovered.