Estradiol (medication)
Estradiol is also available in the U.S. in combination with progestogens for the treatment of menopausal symptoms and as a combined hormonal contraceptive:Estradiol and estradiol esters are also available in custom preparations from compounding pharmacies in the U.S. This includes subcutaneous pellet implants, which are not available in the United States as FDA-approved pharmaceutical drugs. In addition, topical creams that contain estradiol are generally regulated as cosmetics rather than as drugs in the U.S. and hence are also sold over-the-counter and may be purchased without a prescription on the Internet.
Ethinylestradiol
EE has been marketed as a standalone oral drug under the brand names "Esteed", "Estinyl", "Feminone", "Lynoral", "Menolyn", "Novestrol", "Palonyl", "Spanestrin", and "Ylestrol" among others, although most or all of these formulations are now discontinued. It is marketed under a very large number of brand names throughout the world in combination with progestins for use as an oral contraceptive. In addition, EE is marketed in the in combination with norelgestromin under the brand names "Ortho Evra" and "Xulane" as a contraceptive patch, in combination with etonogestrel under the brand name "NuvaRing" as a contraceptive vaginal ring, and in combination with norethisterone acetate under the brand name "FemHRT" in oral hormone replacement therapy for the treatment of menopausal symptoms.