Lithium hydride
Before the Castle Bravo nuclear weapons test in 1954, it was thought that only the less common isotope lithium-6 would breed tritium when struck with fast neutrons. The Castle Bravo test showed (accidentally) that the more plentiful lithium-7 also does so under extreme conditions, albeit by an endothermic reaction.
Pacific Proving Grounds
Six very large nuclear tests were conducted at the Bikini Atoll and the Enewetak Atoll as part of Operation Castle in 1954. The most notable was Castle Bravo, which was the first deployable (dry fuel) hydrogen bomb developed by the United States. Its yield, at 15 Mt, was over twice as powerful as was predicted, and was the largest weapon ever detonated by the United States. It spread nuclear fallout over a wide area, including the Enewetak Atoll, Rongerik Atoll, Ailinginae Atoll, and Rongelap Atoll. The U.S. Navy evacuated the islanders within the next few days, but many of the natives exposed suffered from cancers and a high incidence of birth defects in the years following the event. The fishermen aboard the Japanese fishing vessel, the "Daigo Fukuryu Maru", were additionally exposed and one man died soon after from complications of radiation sickness, resulting in considerable international controversy.