Estradiol (medication)
Estradiol is available in a variety of different formulations, including oral, intranasal, transdermal/topical, vaginal, injectable, and implantable preparations. An ester may be attached to one or both of the hydroxyl groups of estradiol to improve its oral bioavailability and/or duration of action with injection. Such modifications give rise to forms such as estradiol acetate (oral and vaginal), estradiol valerate (oral and injectable), estradiol cypionate (injectable), estradiol benzoate (injectable), estradiol undecylate (injectable), and polyestradiol phosphate (injectable; a polymerized ester of estradiol), which are all prodrugs of estradiol.
Estradiol monopropionate
Estradiol monopropionate (brand names Acrofollin, Agofollin, Akrofollin, Di-Ovahormon Depot, Follhormon, Ovocylin), also known as estradiol 17β-propionate or estradiol 17β-propanoate, as well as estra-1,3,5(10)-trien-3,17β-diol 17β-propionate, is a synthetic, steroidal estrogen and an estrogen ester – specifically, the C17β propionate ester of estradiol – which was first marketed in the late 1930s or early 1940s.