Estradiol sulfate
As the sodium salt, sodium estradiol sulfate, E2S is present as a minor constituent (0.9%) of conjugated equine estrogens (CEEs), or Premarin. It effectively functions as a prodrug to estradiol in this preparation, similarly to E1S. E2S is also formed as a metabolite of estradiol, as well as of estrone and E1S. Aside from its presence in CEEs, E2S is not available as a commercial pharmaceutical drug.
Estradiol (medication)
Estrogens are involved in breast development and estradiol may be used as a form of hormonal breast enhancement to increase the size of the breasts. Both pseudopregnancy with a combination of high-dosage intramuscular estradiol valerate and hydroxyprogesterone caproate and polyestradiol phosphate monotherapy have been assessed for this purpose in clinical studies. However, acute or temporary breast enlargement is a well-known side effect of estrogens, and increases in breast size tend to regress or disappear entirely following discontinuation of treatment. Aside from in those without prior established breast development, evidence is lacking for long-term or sustained increases in breast size with estrogens.