Lawrence, Kansas
Prior to Kansas Territory being established in May 1854, most of Douglas County was part of the Shawnee Indian Reservation (created in 1830). During this period, the Oregon Trail ran parallel to the Kansas River, roughly through the area where Lawrence would eventually be situated and a hill known then as "Hogback Ridge" (i.e., Mount Oread, which sits on the water divide separating the Kansas and Wakarusa River). This area was used as a landmark and an outlook by those on the trail. While this territory was technically unopened to settlement prior to 1854, there did exist a few "squatter settlements" in the area, especially just north of the Kansas River.
Kansas Territory
The territory extended from the Missouri border west to the summit of the Rocky Mountains and from the 37th parallel north to the 40th parallel north. Originally part of Missouri Territory, it was unorganized from 1821 to 1854. Much of the eastern region of what is now the State of Colorado was part of Kansas Territory. The Territory of Colorado was created to govern this western region of the former Kansas Territory on February 28, 1861.