Lawrence, Kansas
Prior to Kansas Territory being established in May 1854, most of Douglas County was part of the Shawnee Indian Reservation (created in 1830). During this period, the Oregon Trail ran parallel to the Kansas River, roughly through the area where Lawrence would eventually be situated and a hill known then as "Hogback Ridge" (i.e., Mount Oread, which sits on the water divide separating the Kansas and Wakarusa River). This area was used as a landmark and an outlook by those on the trail. While this territory was technically unopened to settlement prior to 1854, there did exist a few "squatter settlements" in the area, especially just north of the Kansas River.
Department of Kansas
The first "Department of Kansas" was created on November 9, 1861 from the Western Department. It included Kansas, Nebraska Territory, Colorado Territory, Dakota Territory and the Indian Territory (present day Oklahoma). On March 11, 1862 the department was absorbed into the Department of the Mississippi. Brigadier General David Hunter was the sole commander during this period. During this interlude a District of Kansas existed under the command of Brigadier General James W. Denver from March 19-April 10, 1862.