Enrico Fermi
Fermi wrote a paper "On the Origin of Cosmic Radiation" in which he proposed that cosmic rays arose through material being accelerated by magnetic fields in interstellar space, which led to a difference of opinion with Teller. Fermi examined the issues surrounding magnetic fields in the arms of a spiral galaxy. He mused about what is now referred to as the "Fermi paradox": the contradiction between the presumed probability of the existence of extraterrestrial life and the fact that contact has not been made.
Toward the end of his life, Fermi questioned his faith in society at large to make wise choices about nuclear technology. He said:
Physical paradox
A further set of physical paradoxes are based on sets of observations that fail to be adequately explained by current physical models. These may simply be indications of the incompleteness of current theories. It is recognized that unification has not been accomplished yet which may hint at fundamental problems with the current scientific paradigms. Whether this is the harbinger of a scientific revolution yet to come or whether these observations will yield to future refinements or be found to be erroneous is yet to be determined. A brief list of these yet inadequately explained observations includes observations implying the existence of dark matter, observations implying the existence of dark energy, the observed matter-antimatter asymmetry, the GZK paradox, the heat death paradox, and the Fermi paradox.