Enrico Fermi
Fermi wrote a paper "On the Origin of Cosmic Radiation" in which he proposed that cosmic rays arose through material being accelerated by magnetic fields in interstellar space, which led to a difference of opinion with Teller. Fermi examined the issues surrounding magnetic fields in the arms of a spiral galaxy. He mused about what is now referred to as the "Fermi paradox": the contradiction between the presumed probability of the existence of extraterrestrial life and the fact that contact has not been made.
Toward the end of his life, Fermi questioned his faith in society at large to make wise choices about nuclear technology. He said:
Fermi paradox
It is possible, however, that present scientific knowledge cannot properly gauge the feasibility and costs of such interstellar colonization. Theoretical barriers may not yet be understood, and the resources needed may be so great as to make it unlikely that any civilization could afford to attempt it. Even if interstellar travel and colonization are possible, they may be difficult, leading to a colonization model based on percolation theory. Colonization efforts may not occur as an unstoppable rush, but rather as an uneven tendency to "percolate" outwards, within an eventual slowing and termination of the effort given the enormous costs involved and the expectation that colonies will inevitably develop a culture and civilization of their own. Colonization may thus occur in "clusters," with large areas remaining uncolonized at any one time.