Estradiol valerate
In addition to single-drug formulations, oral estradiol valerate is available in combination with the progestin dienogest as a combined oral contraceptive and intramuscular estradiol valerate is marketed in combination with the progestins hydroxyprogesterone caproate and norethisterone enantate as combined injectable contraceptives. Intramuscular estradiol valerate has also been marketed in combination with testosterone enantate, but this formulation has been discontinued. The availability of estradiol valerate-containing products varies throughout the world.
Ethinylestradiol
EE has been marketed as a standalone oral drug under the brand names "Esteed", "Estinyl", "Feminone", "Lynoral", "Menolyn", "Novestrol", "Palonyl", "Spanestrin", and "Ylestrol" among others, although most or all of these formulations are now discontinued. It is marketed under a very large number of brand names throughout the world in combination with progestins for use as an oral contraceptive. In addition, EE is marketed in the in combination with norelgestromin under the brand names "Ortho Evra" and "Xulane" as a contraceptive patch, in combination with etonogestrel under the brand name "NuvaRing" as a contraceptive vaginal ring, and in combination with norethisterone acetate under the brand name "FemHRT" in oral hormone replacement therapy for the treatment of menopausal symptoms.