Nuclear triad
Israel is known to have nuclear-capable aircraft and land-base missiles, with the addition of nuclear-armed submarines this would mean that they now have a full triad of land-, air-, and sea-based nuclear delivery systems some of which would be invulnerable to a first strike by an enemy for the first time in their country's history. No other nation in the Middle East in known to be in possession of nuclear weapons, even though Iran, Iraq, Syria and Libya have started development programs that were never completed.
Pakistan and weapons of mass destruction
Pakistan is one of nine states to possess nuclear weapons. Pakistan began development of nuclear weapons in January 1972 under Prime Minister Zulfikar Ali Bhutto, who delegated the program to the Chairman of the Pakistan Atomic Energy Commission (PAEC) Munir Ahmad Khan with a commitment to having the bomb ready by the end of 1976. Since PAEC, consisting of over twenty laboratories and projects under nuclear engineer Munir Ahmad Khan, was falling behind schedule and having considerable difficulty producing fissile material, Abdul Qadeer Khan was brought from Europe by Bhutto at the end of 1974. As pointed out by Houston Wood, Professor of Mechanical & Aerospace Engineering, University of Virginia, Charlottesville, in his article on gas centrifuges, "The most difficult step in building a nuclear weapon is the production of fissile material"; as such, this work in producing fissile material as head of the Kahuta Project was pivotal to Pakistan developing the capability to detonate a nuclear bomb by the end of 1984.