Chondrichthyes
Chondrichthyes nervous system is composed of a small brain, 8-10 pairs of cranial nerves, and a spinal chord with spinal nerves. They have several sensory organs which provide information to be processed. Ampullae of Lorenzini are a network of small jelly filled pores called electroreceptors which help the fish sense electric fields in water. This aids in finding prey, navigation, and sensing temperature. The Lateral line system has modified epithelial cells located externally which sense motion, vibration, and pressure in the water around them. Most subspecies have large well-developed eyes. Also, they have very powerful nostrils and olfactory organs. Their inner ears consist of 3 large semicircular canals which aid in balance and orientation. Their sound detecting apparatus has limited range and is typically more powerful at lower frequencies. Some subspecies have electric organs which can be used for defense and predation. They have relatively simple brains with the forebrain not greatly enlarged. The structure and formation of myelin in their nervous systems are nearly identical to that of tetrapods, which has led evolutionary biologists to believe that Chondrichthyes were a cornerstone group in the evolutionary timeline of myelin development.
Pain in fish
Microarray analysis of gene expression shows the brain is active at the molecular level in the forebrain, midbrain and hindbrain of common carp and rainbow trout. Several genes involved in mammalian nociception, such as brain-derived neurotrophic factor (BDNF) and the cannabinoid CB1 receptor are regulated in the fish brain after a nociceptive event.