Nuclear triad
Israel is known to have nuclear-capable aircraft and land-base missiles, with the addition of nuclear-armed submarines this would mean that they now have a full triad of land-, air-, and sea-based nuclear delivery systems some of which would be invulnerable to a first strike by an enemy for the first time in their country's history. No other nation in the Middle East in known to be in possession of nuclear weapons, even though Iran, Iraq, Syria and Libya have started development programs that were never completed.
Nuclear arms race
In addition to the United States and the Soviet Union, three other nations, the United Kingdom, People's Republic of China, and France developed nuclear weapons during the early cold war years.