Alison Krauss
As of 2018, she has won 27 Grammy Awards from 42 nominations, tying her for the second most awarded recipient alongside Quincy Jones, second only to classical conductor Georg Solti, who holds the record for most wins with 31. She is the most awarded singer and the most awarded female artist in Grammy history.
Grammy Award for Best Rock Instrumental Performance
Two-time recipients include Eric Clapton, Carlos Santana (once as a member of the band Santana), The Flaming Lips, Steve Vai, and brothers Jimmie Vaughan and Stevie Ray Vaughan (each once as part of the duo Vaughan Brothers). At the 51st Grammy Awards (2009), the tribute act Zappa Plays Zappa (led by Dweezil Zappa, son of Frank Zappa) earned an award for their performance of Frank's instrumental song "Peaches en Regalia". Dweezil and Frank have both received multiple nominations and even competed against one another in 1988. Joe Satriani holds the record for the most nominations (as well as the record for the most nominations without a win), with fourteen.