Kennedy Space Center
On February 1, 2003, "Columbia" and her crew of seven were lost during re-entry over Texas during the STS-107 mission (the 113th shuttle flight); a vehicle breakup triggered by damage sustained during launch from Pad 39A on January 16, when a piece of foam insulation from the orbiter's external fuel tank struck the orbiter's left wing. During reentry, the damage created a hole allowing hot gases to melt the wing structure. Like the "Challenger" disaster, the resulting investigation and modifications interrupted shuttle flight operations at KSC for more than two years until the STS-114 launch on July 26, 2005.
Space Shuttle program
The accidents led to national level inquiries and detailed analysis of why the accidents occurred. There was a significant pause where changes were made before the Shuttles returned to flight. The "Columbia" disaster occurred in 2003, but STS took more than a year off before returning to flight in June 2005 with the STS-114 mission. The previous break was between January 1986 (when the "Challenger" disaster occurred) and 32 months later when STS-26 was launched on September 29, 1988.