Box jellyfish
Although the notoriously dangerous species of box jellyfish are largely restricted to the tropical Indo-Pacific region, various species of box jellyfish can be found widely in tropical and subtropical oceans, including the Atlantic Ocean and the east Pacific Ocean, with species as far north as California ("Carybdea confusa"), the Mediterranean Sea ("Carybdea marsupialis") and Japan (such as "Chironex yamaguchii"), and as far south as South Africa (for example, "Carybdea branchi") and New Zealand (such as "Copula sivickisi").
Box jellyfish
In Australia, fatalities are most often caused by the largest species of this class of jellyfish, "Chironex fleckeri". Researchers at the University of Hawaii's Department of Tropical Medicine found the venom causes cells to become porous enough to allow potassium leakage, causing hyperkalemia, which can lead to cardiovascular collapse and death as quickly as within 2 to 5 minutes. It was postulated that a zinc compound may be developed as an antidote.