Stegodyphus lineatus
The act of reproduction, regarding the female, leads to an increase of digestive enzymes. This allows her to eat more prey and to stock more nutrients. The digestive enzymes then start to digest the inside of the organism itself, except for the heart, guts, and mostly the ovaries. Once the offspring are born, and until the mother dies, the mother regurgitates for two weeks the fluids stocked inside as highly nutritive food for the progeny. Ninety-five per cent of the mother's mass is digested by the offspring. They will grow to three times their original size between their birth and dispersion. During the period when female spiders are caring for their hatched offspring, the mothers do not eat, and their offspring only eat the food that the mother regurgitates along with the mother's body at the end of this time.
Discovery and development of gastrointestinal lipase inhibitors
The lipase inhibitors lipstatin and orlistat act locally in the intestinal tract. They are minimally absorbed in the circulation because of their lipophilicity. Hence, they do not affect systemic lipases. 
The mechanism of lipase inhibitors in fat digestion is shown in figure 1. These inhibitors bind covalently as an ester to the serine hydroxyl group at the active site on pancreatic- and gastric lipases and form a stable complex.
This results in a conformational change in the enzyme which causes exposing of the catalytic active site. When the active site is exposed, the hydroxyl group on the serine residue is acylated. This leads to irreversible inactivation of the enzyme. 
The inactive lipase is incapable of hydrolysing fats into absorbable fatty acids and monoglycerides, therefore triglycerides are excreted undigested with faeces. With this mode of action calorie uptake from fat in food is limited, hence body weight is reduced. The main role of lipase inhibitors is therefore to inhibit lipases in the gastrointestinal tract, but they do not have significant activity against proteases, amylases or other digestive enzymes.