Nuclear triad
Israel is known to have nuclear-capable aircraft and land-base missiles, with the addition of nuclear-armed submarines this would mean that they now have a full triad of land-, air-, and sea-based nuclear delivery systems some of which would be invulnerable to a first strike by an enemy for the first time in their country's history. No other nation in the Middle East in known to be in possession of nuclear weapons, even though Iran, Iraq, Syria and Libya have started development programs that were never completed.
List of states with nuclear weapons
Nuclear weapons have been present in many nations, often as staging grounds under control of other powers. However, in only one instance has a nation given up nuclear weapons after being in full control of them. The fall of the Soviet Union left several former Soviet republics in physical possession of nuclear weapons, though not operational control which was dependent on Russian-controlled electronic Permissive Action Links and the Russian command and control system.