Mitochondrial matrix
The cytosolic, intermembrane space, compartment has a water content of 3.8 μl/mg protein, while the mitochondrial matrix 0.8 μl/mg protein. It is not known how mitochondria maintain osmotic balance across the inner mitochondrial membrane, although the membrane contains aquaporins that are believed to be conduits for regulated water transport. Mitochondrial matrix has a pH of about 7.8. Mitochondrial DNA was discovered by Nash and Margit in 1963. One to many double stranded mainly circular DNA is present in mitochondrial matrix. Mitochondrial DNA is 1% of total DNA of a cell. It is rich in Guanine and Cytosine content. Mitochondria of mammals have 55s ribosomes.
Science and technology in Switzerland
Friedrich Miescher was a Swiss physician who was the first researcher to isolate and characterize Nucleic acid (DNA). Today, a research institute in Basel (the Friedrich Miescher Institute, FMI) is named after him. Emil Theodor Kocher (Nobel Prize in Physiology or Medicine 1909) was known for his work in the physiology, pathology and surgery of the thyroid. The neurologist Walter Rudolf Hess (Nobel Prize in Physiology or Medicine 1949) mapped the areas of the brain that were responsible for the control of several vital bodily functions. The biochemist Werner Arber (Nobel Prize in Physiology or Medicine 1978) is known for his discovery of restriction endonucleases which are essential for all modern biotechnology. The Swiss born Edmond H. Fischer (Nobel Prize in Physiology or Medicine 1992) discovered how reversible phosphorylation works as a switch to activate proteins. Rolf M. Zinkernagel (Nobel Prize in Physiology or Medicine 1996) is famous for his work on the immune system.