Astemizole
Astemizole (marketed under the brand name Hismanal, developmental code R43512) was a second-generation antihistamine drug that has a long duration of action. Astemizole was discovered by Janssen Pharmaceutica in 1977. It has been withdrawn from the market in most countries because of rare but potentially fatal side effects (QTc interval prolongation and related arrhythmias due to hERG channel blockade).
Hashish
It has been claimed that the user’s psychological and physiological needs will influence the response and that the user must cooperate with and facilitate the effects. Therefore, the effect of the physical and interpersonal setting is strong and usually controls the underlying tone of the experience. Generally the intensification of sensation and increased clarity of perception have been reported. Short lived adverse effects have also been reported, including psychotic states following heavy consumption. Regular users are at risk of dependence. Especially people with major mental illnesses e.g. schizophrenia are vulnerable as hashish provokes relapse and aggravates existing symptoms.