Estradiol (medication)
Estradiol is also available in the U.S. in combination with progestogens for the treatment of menopausal symptoms and as a combined hormonal contraceptive:Estradiol and estradiol esters are also available in custom preparations from compounding pharmacies in the U.S. This includes subcutaneous pellet implants, which are not available in the United States as FDA-approved pharmaceutical drugs. In addition, topical creams that contain estradiol are generally regulated as cosmetics rather than as drugs in the U.S. and hence are also sold over-the-counter and may be purchased without a prescription on the Internet.
Estriol (medication)
Following its discovery in 1930, estriol was introduced for medical use as an oral tablet in the 1930s. Emmenin and Progynon were oral estrogens that contained estriol conjugates, primarily estriol glucuronide, and were introduced in the 1930s. They were the first orally active estrogen preparations to be introduced in medicine. Estriol continues to be used medically today, widely throughout the world and in a variety of different formulations and brand names.