Lawrence, Kansas
Prior to Kansas Territory being established in May 1854, most of Douglas County was part of the Shawnee Indian Reservation (created in 1830). During this period, the Oregon Trail ran parallel to the Kansas River, roughly through the area where Lawrence would eventually be situated and a hill known then as "Hogback Ridge" (i.e., Mount Oread, which sits on the water divide separating the Kansas and Wakarusa River). This area was used as a landmark and an outlook by those on the trail. While this territory was technically unopened to settlement prior to 1854, there did exist a few "squatter settlements" in the area, especially just north of the Kansas River.
Kansas Territory
The first territorial appointments, looking to the inauguration of a local government, under the provisions of the organic law, were made in June and July 1854. The officers appointed by President Pierce, whose appointments were confirmed by the United States Senate, and who entered upon the duties of their officer. The first governor was Andrew Horatio Reeder (of Easton, Pennsylvania) was appointed June 29, 1854 and removed July 28, 1858.