Microglia
Research has discovered dystrophic (defective development) human microglia. "These cells are characterized by abnormalities in their cytoplasmic structure, such as deramified, atrophic, fragmented or unusually tortuous processes, frequently bearing spheroidal or bulbous swellings." The incidence of dystrophic microglia increases with aging. Microglial degeneration and death have been reported in research on Prion disease, Schizophrenia and Alzheimer's disease, indicating that microglial deterioration might be involved in neurodegenerative diseases. A complication of this theory is the fact that it is difficult to distinguish between "activated" and "dystrophic" microglia in the human brain.
Discovery of cosmic microwave background radiation
Over two decades later, working at Bell Labs in Holmdel, New Jersey, in 1964, Arno Penzias and Robert Wilson were experimenting with a supersensitive, 6 meter (20 ft) horn antenna originally built to detect radio waves bounced off Echo balloon satellites. To measure these faint radio waves, they had to eliminate all recognizable interference from their receiver. They removed the effects of radar and radio broadcasting, and suppressed interference from the heat in the receiver itself by cooling it with liquid helium to −269 °C, only 4 K above absolute zero.
When Penzias and Wilson reduced their data they found a low, steady, mysterious noise that persisted in their receiver. This residual noise was 100 times more intense than they had expected, was evenly spread over the sky, and was present day and night. They were certain that the radiation they detected on a wavelength of 7.35 centimeters did not come from the Earth, the Sun, or our galaxy. After thoroughly checking their equipment, removing some pigeons nesting in the antenna and cleaning out the accumulated droppings, the noise remained. Both concluded that this noise was coming from outside our own galaxy—although they were not aware of any radio source that would account for it.