Health in Malaysia
Leptospirosis is a water contract disease caused by bacteria of the genus Leptospirabacterial. It is a disease that affects both humans and animals. The number of leptospirosis cases had steadily increased from 2011 (2,268 cases with 55 death) to 2015 (8,291 cases with 78 death) and 5,284 cases with 52 death in 2016. Leptospirosis can have important health impact and is a burden to the nation if not well controlled. Addressing leptospisoris includes maintain a clean environment and by not swimming or wading in water that might be contaminated with animal urine, or eliminating contact with potentially infected animals.
Hepatitis
Severe alcoholic hepatitis has a poor prognosis and is notoriously difficult to treat. Without any treatment, 20-50% of patients may die within a month, but evidence shows treatment may extend life beyond one month (i.e., reduce short-term mortality). Available treatment options include pentoxifylline (PTX), which is a nonspecific TNF inhibitor, corticosteroids, such as prednisone or prednisolone (CS), corticosteroids with "N"-acetylcysteine (CS with NAC), and corticosteroids with pentoxifylline (CS with PTX). Data suggest that CS alone or CS with NAC are most effective at reducing short-term mortality. Unfortunately, corticosteroids are contraindicated in some patients, such as those who have active gastrointestinal bleeding, infection, kidney failure, or pancreatitis. In these cases PTX may be considered on a case by case basis in lieu of CS; some evidence shows PTX is better than no treatment at all and may be comparable to CS while other data show no evidence of benefit over placebo. Unfortunately, there are currently no drug treatments that decrease these patients’ risk of dying in the longer term, at 3–12 months and beyond.