Lithium hydride
Before the Castle Bravo nuclear weapons test in 1954, it was thought that only the less common isotope lithium-6 would breed tritium when struck with fast neutrons. The Castle Bravo test showed (accidentally) that the more plentiful lithium-7 also does so under extreme conditions, albeit by an endothermic reaction.
Nuclear weapon design
The global alarm over radioactive fallout, which began with the Castle Bravo event, eventually drove nuclear testing literally underground. The last U.S. above-ground test took place at Johnston Island on November 4, 1962. During the next three decades, until September 23, 1992, the United States conducted an average of 2.4 underground nuclear explosions per month, all but a few at the Nevada Test Site (NTS) northwest of Las Vegas.