Estradiol (medication)
Estradiol is also available in the U.S. in combination with progestogens for the treatment of menopausal symptoms and as a combined hormonal contraceptive:Estradiol and estradiol esters are also available in custom preparations from compounding pharmacies in the U.S. This includes subcutaneous pellet implants, which are not available in the United States as FDA-approved pharmaceutical drugs. In addition, topical creams that contain estradiol are generally regulated as cosmetics rather than as drugs in the U.S. and hence are also sold over-the-counter and may be purchased without a prescription on the Internet.
Estetrol (medication)
In addition to a single-drug formulation, estetrol is under development in combination with the progestin drospirenone for use as a birth control pill to prevent pregnancy with the tentative brand name Estelle. Drospirenone is also a potent antimineralocorticoid and antiandrogen in addition to progestogen, and in relation to this, is said to have a progesterone-like medication profile. As of April 2018, estetrol/drospirenone are in phase III clinical trials for pregnancy prevention.