Lawrence, Kansas
Prior to Kansas Territory being established in May 1854, most of Douglas County was part of the Shawnee Indian Reservation (created in 1830). During this period, the Oregon Trail ran parallel to the Kansas River, roughly through the area where Lawrence would eventually be situated and a hill known then as "Hogback Ridge" (i.e., Mount Oread, which sits on the water divide separating the Kansas and Wakarusa River). This area was used as a landmark and an outlook by those on the trail. While this territory was technically unopened to settlement prior to 1854, there did exist a few "squatter settlements" in the area, especially just north of the Kansas River.
History of the Kansas City metropolitan area
The history of the Kansas City metropolitan area started in the 19th century as Frenchmen from St. Louis, Missouri moved up the Missouri River to trap for furs and trade with the Native Americans. The Kansas City metropolitan area, straddling the border between Missouri and Kansas at the confluence of the Kansas and Missouri Rivers, was a strategic point for commerce and security. Kansas City, Missouri was founded in 1838 and defeated its rival Westport to become the predominant city west of St. Louis. The area played a major role in the westward expansion of the United States. The Santa Fe, and Oregon trails ran through the area. In 1854, when Kansas was opened to Euro-American settlement, the Missouri-Kansas border became the first battlefield in the conflict in the American Civil War.