Lithium hydride
Before the Castle Bravo nuclear weapons test in 1954, it was thought that only the less common isotope lithium-6 would breed tritium when struck with fast neutrons. The Castle Bravo test showed (accidentally) that the more plentiful lithium-7 also does so under extreme conditions, albeit by an endothermic reaction.
Pacific Proving Grounds
The United States conducted 105 atmospheric and underwater (i.e., not underground) nuclear tests in the Pacific, many of which were of extremely high yield. While the Marshall Islands testing composed 14% of all U.S. tests, it composed nearly 80% of the total yields of those detonated by the U.S., with an estimated total yield of around 210 megatons, with the largest being the 15 Mt Castle Bravo shot of 1954 which spread considerable nuclear fallout on many of the islands, including several which were inhabited, and some that had not been evacuated.