Cholera outbreaks and pandemics
That year, cholera was transmitted along the California, Mormon and Oregon Trails as 6,000 to 12,000 are believed to have died on their way to the California Gold Rush, Utah and Oregon in the cholera years of 1849–1855. It is believed more than 150,000 Americans died during the two pandemics between 1832 and 1849.
Appalachian Trail
Human error can lead to casualties as well. In July 2013, 66-year-old lone hiker Geraldine Largay disappeared on the trail in Maine. She got very lost and survived 26 days before dying. Her remains were found 2 years later in October 2015. In October 2015, a hiker visiting from England was killed on the trail by falling while taking photos at the Annapolis Rocks overlook in Maryland.