Fonar Corp. v. General Electric Co.
"Fonar" was a dispute between medical device manufacturer Fonar Corporation and General Electric over Fonar's patent on MRI technology. Fonar's founder, Raymond Damadian, was issued U.S. Patent 3,789,832 (priority date 1972-03-17) for an "apparatus and method for detecting cancer in tissue" using the magnetic resonance of atoms. Damadian's patent was the first patent on an MRI machine issued in the United States. Also at issue was a later patent, U.S. Patent 4,871,966 issued in 1989, covering a method for obtaining MRI images of multiple planes at different orientations in a single scan. GE is a major manufacturer of MRI scanners, and Fonar sued GE for infringing these patents by producing its scanners as well as inducing others to infringe.
Mass spectrometry imaging
More than 50 years ago, IMS was introduced using secondary ion mass spectrometry (SIMS) to study semiconductor surfaces by Castaing and Slodzian. However, it was the pioneering work of Richard Caprioli and colleagues in the late 1990s, demostrating how matrix-assisted laser desorption/ionization (MALDI) could be applied to visualize large biomolecules (as proteins and lipids) in cells and tissue to reveal the function of these molecules and how function is changed by diseases like cancer, which led to the widespread use of IMS. Nowadays, different ionization techniques have been used, including SIMS, MALDI and desorption electrospray ionization (DESI), as well as other technologies. Still, MALDI is the current dominant technology with regard to clinical and biological applications of MSI.