Gender in speculative fiction
The first known female superhero is writer-artist Fletcher Hanks's minor character Fantomah, an ageless, ancient Egyptian woman in the modern day who could transform into a skull-faced creature with superpowers to fight evil; she debuted in 1940 in Fiction Houses "Jungle Comics".
The Secrets of Isis
The program was the first weekly, American, live-action television series with a female superhero lead character (debuting September 6, 1975, predating the "weekly" debuts of both "The Bionic Woman" (January 14, 1976), and, "Wonder Woman" (April 21, 1976)). In the series, Isis (Joanna Cameron) is the alter ego of Andrea Thomas, a seemingly normal schoolteacher, who transforms into the Egyptian goddess when presented with crises a mere mortal cannot resolve.