U.S. Route 101
The nearly highway's northern terminus is in Tumwater, Washington: the route remains along the Olympic Peninsula's coastal perimeter west, north, and east; the northernmost point on the highway is in Port Angeles. The southern terminus of US 101 is in Los Angeles at the East Los Angeles Interchange, the world's busiest freeway interchange.
Ohio State Route 101
Soon after entering Sandusky County, SR 101 makes a left turn to head due north towards the city of Clyde. Through the city, SR 101 first travels along South Main Street. In the center, SR 101 turns northeast onto East Maple Street while SR 510 continues north along Main Street. The highway intersects US 20 inside the city limits but exits soon after. Heading northeasterly again, the road again passes through mainly farmland but single-family homes line the road throughout the rest of its trip through Sandusky County. The highway passes over the Ohio Turnpike (Interstates 80 and 90) without an interchange and intersects SR 412 at its eastern terminus. About east of this intersection, SR 101 enters Erie County. At first, SR 101 deviates from its northeasterly bearing and travels more northerly before curving to due east following the southern border of Castalia. At a T-intersection with SR 269, SR 101 turns left onto SR 269 passing through a mostly residential neighborhood of the village on Washington Street. After crossing a culvert over the Castalia Pond, the road comes to the central business district of the village. SR 101 ends its concurrency with SR 269 by turning right onto Main Street. The road heads back to its northeastern bearing and comes to an interchange with the SR 2 freeway. About northeast of the interchange, just before reaching the Sandusky city limits, SR 101 makes a sharp reverse curve towards the north passing through a light industrial area of western Sandusky before reaching an intersection with US 6. The official SR 101 designation ends at this intersection however signage shows SR 101 traveling east along US 6 into downtown Sandusky. After the aforementioned intersection, US 6 and SR 101 pass over a Norfolk Southern railroad on an overpass and curve to the northeast to travel along Tiffin Avenue. Tiffin Avenue and Washington Street pass mostly through residential neighborhoods until it reaches Washington Park in the center of the city. Signage for SR 101 ends at its intersection with Columbus Avenue which also marks the northern terminus of SR 4. US 6 continues east along Washington Street for another block.