Margherita Colonna
She was born in Palestrina about 1255. Her father, Oddone Colonna, died when she was about two years old. Her mother, who was also named Margherita and who was the sister of Matteo Rosso Orsini and a pious woman, died when Margherita was probably a little over ten years old. Margherita was left in the care of her older brothers.
Alfonso de la Cueva, 1st Marquis of Bedmar
De la Cueva opted however for the order of bishops and the suburbicarian see of Palestrina, on 17 October 1644. He was consecrated on 23 October 1644. Named bishop of Málaga, retaining the diocese of Palestrina on 27 July 1648, he did not take possession of the diocese until 1651. He did not participate in the papal conclave of 1655.