Plasmodium falciparum
Plasmodium falciparum is a unicellular protozoan parasite of humans, and the deadliest species of "Plasmodium" that cause malaria in humans. It is transmitted through the bite of a female "Anopheles" mosquito. It is responsible for roughly 50% of all malaria cases. It causes the disease's most dangerous form called falciparum malaria. It is therefore regarded as the deadliest parasite in humans, causing 435,000 deaths in 2017. It is also associated with the development of blood cancer (Burkitt's lymphoma) and is classified as Group 2A carcinogen.
Josiah C. Nott
Nott took up theories that the mosquito was a vector for malaria, held by John Crawford and his contemporary Lewis Daniel Beauperthy. He is credited as being the first to apply the insect vector theory to yellow fever, then a serious health problem of the American South. In his 1850 "Yellow Fever Contrasted with Bilious Fever" he attacked the prevailing miasma theory. Nott lost four of his children to yellow fever in one week in September 1853.