Chameleon (comics)
Created by writer Stan Lee and artist Steve Ditko, the character first appeared in "The Amazing Spider-Man" #1 (March 1963), making him the first member of Spider-Man's rogues' gallery, based on issue publication date, excluding the burglar who murdered Ben Parker (Supercharger was the first Spider-Man supervillain chronologically). He is also well known to be related to Kraven the Hunter. That revealed relationship helped evolve him as a major villain compared to his original depiction of being just a solo villain in the original issue of "The Amazing Spider-Man".
Lion of Macedon
There, Parmenion starts a new life as a professional runner. Thebes is under the control of Sparta, governed by a puppet-government of pro–Spartan Thebans and occupied by a Spartan garrison. Parmenion becomes involved with Thebian conspirators who seek to overthrow Spartan control. Their revolt succeeds and the Spartans are expelled but it ultimately leads to an extended war between to the two city states, ending with Parmenion crushing the Spartan army, destroying the Spartan legend of invincibility in the process.