Chameleon (comics)
Following the "Dying Wish" storyline, Chameleon later fights Superior Spider-Man (Otto Octavius's mind in Spider-Man's body) and the Secret Avengers on the S.H.I.E.L.D. Helicarrier. Chameleon ends up knocked unconscious and Superior Spider-Man transports him to his hidden underwater lab where he ends up imprisoned. Chameleon, Electro, Sandman, Mysterion, and the Vulture are later seen as part of a team led by Superior Spider-Man called the "Superior Six". Superior Spider-Man has been temporarily controlling their minds in order to redeem them for their crimes. He does this by forcing them do heroic deeds against their will which almost get some of them killed. Every time he is done controlling them, he puts them back in their containment cells. They eventually break free of Superior Spider-Man's control and attempt to exact revenge on the wall-crawler, while nearly destroying New York in order to do so. With the help of Sun Girl, Superior Spider-Man is barely able to stop the Superior Six.
Chameleon (comics)
However, the Chameleon was dealt a most humiliating defeat at the hands of Aunt May, when he attempted to trick her into believing he was Peter, then murder her. However, May was not fooled by any means, and defeated the villain with a plate of oatmeal-raisin cookies laced with Ambien. The Rhino was also employed as part of the team up and later defeated Spider-Man only to be unable to collect payment from Chameleon as he was already captured.