Prothoracicotropic hormone
Prothoracicotropic hormone (PTTH) was the first insect hormone to be discovered. It was originally described simply as "brain hormone" by early workers such as Stefan Kopeć (1922) and Vincent Wigglesworth (1934), who realized that ligation of the head of immature insects could prevent molting or pupation of the body region excluded from the head if the ligation was performed before a critical age in the lifestage was reached. After a certain point the ligation had no effect and both sections of the insect would molt or pupate. However, implantation of a conspecific brain to a sessile ligated abdomen or an abdomen under diapause would induce molting or pupation. Thus, the brain was originally thought to be the source of the hormone that induces molting in insects.
Clearblue
In 1989, Clearblue released the first one-step home ovulation test, enabling women to measure their surge in Luteinising Hormone (LH) to determine their most fertile days. In 1999, the brand launched the world’s first dual-hormone fertility monitor, which allowed women to measure estrone3-glucuronide (estrogen) in combination with LH. The company created the first digital ovulation test in 2004. In 2013, the company also began offering an ovulation test with a dual hormone read detecting both estrogen and LH.