History of the East–West Schism
Disunion in the Roman Empire further contributed to disunion in the Church. The Emperor Diocletian famously divided the administration of the eastern and western portions of the Empire in the early 4th century, though subsequent leaders (including Constantine) aspired to and sometimes gained control of both regions. Theodosius the Great, who established Nicene Christianity as the official religion of the Roman Empire (see Edict of Thessalonica), was the last Emperor to rule over a united Roman Empire. Following his death in 395, the division into western and eastern halves, each for a few decades still under its own Emperor, was never reunited.
East–West Schism
In 476, when the last emperor of the western part of the Roman Empire was deposed and the western imperial insignia were sent to Constantinople, there was once again a single Roman Emperor. However, he had little power in the West, which was ruled almost entirely by various Germanic tribes. In the opinion of Randall R. Cloud, the permanent separation of the Greek East from the Latin West was "the fundamental reason for the estrangement that soon followed between the Greek and the Latin Christians".