Chiefdoms of Hispaniola
The Taíno of Hispaniola were an Arawak people related to the inhabitants of the other islands in the Greater Antilles. At the time of European contact, they were suffering attacks from a rival indigenous group, the Island Caribs. In 1508, there were about 60,000 Taínos in the island of Hispaniola; by 1531 infectious disease epidemics and exploitation had resulted in a dramatic decline in population. An estimated 600.
Spanish colonization of the Americas
Columbus made four voyages to the West Indies as the monarchs granted Columbus the governorship of the new territories, and financed more of his trans-Atlantic journeys. He founded La Navidad on the island later named Hispaniola (now divided into Haiti and the Dominican Republic), in what is the present-day Haiti on his first voyage. After its destruction by the indigenous Taino people, the town of Isabella was begun in 1493, on his second voyage. In 1496 his brother, Bartholomew, founded Santo Domingo. By 1500, despite a high death rate, there were between 300 and 1000 Spanish settled in the area. The local Taíno people continued to resist, refusing to plant crops and abandoning their Spanish-occupied villages. The first mainland explorations were followed by a phase of inland expeditions and conquest. In 1500 the city of Nueva Cádiz was founded on the island of Cubagua, Venezuela, followed by the founding of Santa Cruz by Alonso de Ojeda in present-day Guajira peninsula. Cumaná in Venezuela was the first permanent settlement founded by Europeans in the mainland Americas, in 1501 by Franciscan friars, but due to successful attacks by the indigenous people, it had to be refounded several times, until Diego Hernández de Serpa's foundation in 1569. The Spanish founded San Sebastian de Uraba in 1509 but abandoned it within the year. There is indirect evidence that the first permanent Spanish mainland settlement established in the Americas was Santa María la Antigua del Darién.