U.S. Route 101
The nearly highway's northern terminus is in Tumwater, Washington: the route remains along the Olympic Peninsula's coastal perimeter west, north, and east; the northernmost point on the highway is in Port Angeles. The southern terminus of US 101 is in Los Angeles at the East Los Angeles Interchange, the world's busiest freeway interchange.
South Carolina Highway 101
Near Reidville, the road intersects SC 296, and SC 101 intersects SC 417 before passing through Cashville. Near Crescent, South Carolina, SC 101 merges with SC 146 and splits again within the Woodruff city limits. Also, while in Woodruff, Highway 101 intersects both SC 418 and US 221. Once exiting Woodruff, the road takes on a southwest route toward Gray Court, intersecting I-385 at exit 16 along the way. Once exiting Gray Court, South Carolina Highway 101 reaches its southern terminus with US 76 in Hickory Tavern.