Chameleon (comics)
Created by writer Stan Lee and artist Steve Ditko, the character first appeared in "The Amazing Spider-Man" #1 (March 1963), making him the first member of Spider-Man's rogues' gallery, based on issue publication date, excluding the burglar who murdered Ben Parker (Supercharger was the first Spider-Man supervillain chronologically). He is also well known to be related to Kraven the Hunter. That revealed relationship helped evolve him as a major villain compared to his original depiction of being just a solo villain in the original issue of "The Amazing Spider-Man".
Chameleon (comics)
Following the return of the true Spider-Man, Chameleon attempts to drive Spider-Man insane as revenge for the Superior Spider-Man's treatment of him during the events of "Superior Six". However, Spider-Man's ally Deadpool switches costumes with Spider-Man, with Chameleon unaware of this. He fails at driving "Spider-Man" insane (as Deadpool is already insane), and ends up being shot in the leg by him. Both heroes (in each other's costumes) punch the Chameleon at the same time, knocking him out and later delivered him to the authorities.