Extraterrestrial liquid water
The Gliese 581 planetary system contains multiple planets that may be candidates for surface water, including Gliese 581c, Gliese 581d, might be warm enough for oceans if a greenhouse effect was operating, and Gliese 581e.
Interstellar communication
The SETI project has for the past several decades been conducting a search for signals being transmitted by extraterrestrial life located outside the Solar System, primarily in the radio frequencies of the electromagnetic spectrum. Special attention has been given to the Water Hole, the frequency of one of neutral hydrogen's absorption lines, due to the low background noise at this frequency and its symbolic association with the basis for what is likely to be the most common system of biochemistry (see Alternative biochemistry).