Ganciclovir
Ganciclovir has also been used with some success in treating "Human herpesvirus 6" infections.
Herpes simplex research
Diverse subunit HSV vaccines (e.g. Herpevac) have failed to protect humans from acquiring genital herpes in several clinical trials. The success of the chickenpox vaccine demonstrates that a live and appropriately attenuated α-herpesvirus may be used to safely control human disease. A vaccine of this type would present a slow replication process of HSV, thereby also damping down the immune evasion strategies of the virus while simultaneously exposing the host to the full complement of HSV's majority of viral proteins. As a consequence, it is the intent of the vaccine to expose the individual's immune response to the HSV proteins it may have been missing from a wild type virus in order to effectively control the disease. From a historical retrospective, such live attenuated vaccines have had the most success in preventing diseases until today. Dr. William Halford at the Southern Illinois University (SIU) School of Medicine was testing a live-attenuated HSV-2 ICP0‾ vaccine in 2016, before his death in June, 2017. Already proven as safe and effective in studies on animals, eliciting 10 to 100 times greater protection against genital herpes than a glycoprotein D subunit vaccine, Halford's vaccine has been tested outside of the United States, in St. Kitts and is expecting a 2018 test in Australia.