Sidereus Nuncius
The first telescopes appeared in the Netherlands in 1608 when Middelburg spectacle-maker Hans Lippershey tried to obtain a patent on one. By 1609 Galileo had heard about it and built his own improved version. He probably was not the first person to aim the new invention at the night sky but his was the first systematic (and published) study of celestial bodies using one. One of Galileo's first telescopes had 8x to 10x linear magnification and was made out of lenses that he had ground himself. This was increased to 20x linear magnification in the improved telescope he used to make the observations in "Sidereus Nuncius".
Mount Wilson Observatory
The Snow Solar Telescope was the first telescope installed at the fledgling Mount Wilson Solar Observatory. It was the world's first permanently mounted solar telescope. Solar telescopes had previously been portable so they could be taken to solar eclipses around the world. The telescope was donated to Yerkes Observatory by Helen Snow of Chicago. George Ellery Hale, then director of Yerkes, had the telescope brought to Mount Wilson to put it into service as a proper scientific instrument. Its primary mirror with a focal length, coupled with a spectrograph, did groundbreaking work on the spectra of sunspots, doppler shift of the rotating solar disc and daily solar images in several wavelengths. Stellar research soon followed as the brightest stars could have their spectra recorded with very long exposures on glass plates. Today the Snow solar telescope is mostly used by undergraduate students who get hands on training in solar physics and spectroscopy.
It was also used publicly for the May 9, 2016 transit of Mercury across the face of the sun.