Chameleon (comics)
Created by writer Stan Lee and artist Steve Ditko, the character first appeared in "The Amazing Spider-Man" #1 (March 1963), making him the first member of Spider-Man's rogues' gallery, based on issue publication date, excluding the burglar who murdered Ben Parker (Supercharger was the first Spider-Man supervillain chronologically). He is also well known to be related to Kraven the Hunter. That revealed relationship helped evolve him as a major villain compared to his original depiction of being just a solo villain in the original issue of "The Amazing Spider-Man".
Juggernaut (comics)
The Juggernaut continues to feature prominently in Marvel titles, starring in an alternate universe adventure, battling Thor once again and starring opposite other characters such as the mutant team X-Force, Doctor Strange, the Hulk (allied at the time with master villain the Red Skull and tricking and capturing the Hulk with the same "civilian" guise used against Colossus), mercenary Deadpool, the villain turned antihero Venom, and multiple battles with the X-Men. The Juggernaut suffers a major setback during the "Onslaught" storyline, being defeated and then humiliated by the entity when imprisoned in the Gem of Cyttorak. The Juggernaut, however, eventually escapes.