KHON-TV
On October 23, 2006, KHON-TV was announced as the Honolulu affiliate of The CW, carrying the network on its second digital subchannel. Beginning in March 2006 (two months after the network's launch was announced), The CW had struggled to find an affiliate in Honolulu after the market's then-WB affiliate KFVE, which was seen by many as the likeliest candidate to join The CW, signed with competing network MyNetworkTV, and former UPN affiliate KIKU (which aired the network's programming in the afternoons) declined to take the CW affiliation.
WKRC-TV
On January 24, 2006, the Warner Bros. unit of Time Warner and CBS Corporation announced that the two companies would shut down The WB and UPN and combine the networks' respective programming to create a new "fifth" network called The CW. WKRC signed a deal to affiliate with the new network on a new second digital subchannel resulting in UPN affiliate WBQC-CA (channel 25) becoming an independent station. Meanwhile, WB affiliate WSTR-TV joined another new network, News Corporation-owned MyNetworkTV (now owned by 21st Century Fox) which launched on September 5. With the affiliation, WKRC-DT2 became the largest subchannel-only CW affiliate by market size, and was one of the few such stations located in the top 100 markets (most CW-affiliated stations that carry the network via a subchannel are located in the 110 smallest U.S. television markets and carry The CW Plus, an automated feed featuring a pre-packaged schedule of syndicated programs outside CW programming hours; the few that are located among the top 100—such as WTVG-DT2 in Toledo—maintain an independently programmed schedule as their primary channel counterparts do). This distinction ended on May 31, 2017, when San Diego's CBS affiliate, KFMB-TV, affiliated its DT2 subchannel with The CW (which had previously been carried on the primary feed of Tijuana, Mexico-based XETV).