Chameleon (comics)
Created by writer Stan Lee and artist Steve Ditko, the character first appeared in "The Amazing Spider-Man" #1 (March 1963), making him the first member of Spider-Man's rogues' gallery, based on issue publication date, excluding the burglar who murdered Ben Parker (Supercharger was the first Spider-Man supervillain chronologically). He is also well known to be related to Kraven the Hunter. That revealed relationship helped evolve him as a major villain compared to his original depiction of being just a solo villain in the original issue of "The Amazing Spider-Man".
Spider-Man Noir
In order to censor the "Daily Bugle", Osborn kidnaps the editor J. Jonah Jameson and has the Chameleon assume his place. The Chameleon-as-Jameson goes to Urich’s apartment and shoots him, unaware that Felicia witnessed the murder. Hardy goes to the "Daily Bugle" offices and kills the Chameleon, leaving his body to be discovered by Spider-Man shortly before the arrival of the police. Spider-Man escapes the attentions of the police and goes to his home, where he killed the Vulture, in order to stop him from murdering Aunt Parker. Despite saving his aunt, May criticized him for killing the Vulture, as he could have stopped him with his powers. She told Peter that killing people would make him less of what makes him human.