KHON-TV
On October 23, 2006, KHON-TV was announced as the Honolulu affiliate of The CW, carrying the network on its second digital subchannel. Beginning in March 2006 (two months after the network's launch was announced), The CW had struggled to find an affiliate in Honolulu after the market's then-WB affiliate KFVE, which was seen by many as the likeliest candidate to join The CW, signed with competing network MyNetworkTV, and former UPN affiliate KIKU (which aired the network's programming in the afternoons) declined to take the CW affiliation.
KPXJ
On May 1, KPXJ became among of a handful of UPN-affiliated stations not owned by Fox Television Stations to remove on-air brand references to the network – rebranding as "KPXJ 21" – and cease promotion of the network's programs. However, it officially remained a UPN affiliate until September 17, 2006, before affiliating with The CW when that network debuted on September 18. KSHV-TV, meanwhile, joined MyNetworkTV upon that network's launch on September 5; unlike in other markets where The WB and UPN both had over-the-air affiliates — where the WB-turned-MyNetworkTV outlet either disaffiliated from The WB entirely or remained a part-time affiliate during the transition — KPXJ assumed temporary rights to the WB affiliation, carrying the final two weeks of that network's programming between 12:00 a.m. and 2:00 a.m. weeknights and 11:00 p.m. and 2:00 a.m. Sunday/early Mondays until The WB ceased operations on September 17. KPXJ officially affiliated with The CW the following day on September 18, 2006, at which time the station changed its on-air branding to "KPXJ CW 21".