Sidereus Nuncius
The first telescopes appeared in the Netherlands in 1608 when Middelburg spectacle-maker Hans Lippershey tried to obtain a patent on one. By 1609 Galileo had heard about it and built his own improved version. He probably was not the first person to aim the new invention at the night sky but his was the first systematic (and published) study of celestial bodies using one. One of Galileo's first telescopes had 8x to 10x linear magnification and was made out of lenses that he had ground himself. This was increased to 20x linear magnification in the improved telescope he used to make the observations in "Sidereus Nuncius".
Palomar Observatory
The 200-inch telescope was the largest telescope in the world from 1949 until 1975, when the Russian BTA-6 telescope saw first light. Astronomers using the Hale Telescope have discovered distant objects at the edges of the known universe called quasars and have given us the first direct evidence of stars in distant galaxies. They have studied the structure and chemistry of intergalactic clouds, leading to an understanding of the synthesis of elements in the universe, and have discovered thousands of asteroids. A one-tenth-scale engineering model of the telescope at Corning Community College in Corning, New York, home of the Corning Glass Works (now Corning Incorporated) was used to discover at least one minor planet, 34419 Corning.