Chameleon (comics)
Created by writer Stan Lee and artist Steve Ditko, the character first appeared in "The Amazing Spider-Man" #1 (March 1963), making him the first member of Spider-Man's rogues' gallery, based on issue publication date, excluding the burglar who murdered Ben Parker (Supercharger was the first Spider-Man supervillain chronologically). He is also well known to be related to Kraven the Hunter. That revealed relationship helped evolve him as a major villain compared to his original depiction of being just a solo villain in the original issue of "The Amazing Spider-Man".
Peregrine (comics)
Peregrine was first seen in the Grandmaster's Contest of Champions against Death for the life of the Collector. He was chosen to compete on the Grandmaster's side, in the illustrious company of other heroes such as Captain America, Captain Britain, Wolverine, Daredevil, She-Hulk, and the Thing. He was pitted against another winged opponent, the Angel, but the Angel's greater experience gave him the edge to defeat Le Peregrine.