Roman emperor
The Western Roman Empire collapsed in the late 5th century. Romulus Augustulus is often considered to be the last emperor of the West after his forced abdication in 476, although Julius Nepos maintained a claim recognized by the Eastern Empire to the title until his death in 480. Following Nepos' death, the Eastern Emperor Zeno abolished the division of the position and proclaimed himself as the sole Emperor of a reunited Roman Empire. The Eastern imperial lineage continued to rule from Constantinople ("New Rome"); they continued to style themselves as Emperor of the Romans (later βασιλεύς Ῥωμαίων in Greek), but are often referred to in modern scholarship as Byzantine emperors. Constantine XI Palaiologos was the last Roman emperor in Constantinople, dying in the Fall of Constantinople to the Ottomans in 1453.
Parthian Empire
The Sassanians would not only assume Parthia's legacy as Rome's Persian nemesis, but they would also attempt to restore the boundaries of the Achaemenid Empire by briefly conquering the Levant, Anatolia, and Egypt from the Eastern Roman Empire during the reign of Khosrau II ("r". 590–628 AD). However, they would lose these territories to Heraclius—the last Roman emperor before the Arab conquests. Nevertheless, for a period of more than 400 years, they succeeded the Parthian realm as Rome's principal rival.