Scrupulosity
Little evidence is available on the use of medications to treat scrupulosity. Although serotonergic medications are often used to treat OCD, studies of pharmacologic treatment of scrupulosity in particular have produced so few results that even tentative recommendations cannot be made.
Marble burying
Critics also point out that the marble burying test reacts to two types of drugs the SSRIs and benzodiazepines. Benzodiazepines have been shown to have no effect on patients suffering from OCD. If the test measured OCD then benzodiazepines would not affect rodent behavior.