University of Texas MD Anderson Cancer Center
MD Anderson Services Corporation (formerly MD Anderson Cancer Center
Outreach Corporation) was established in 1989 as a not-for-profit corporation to enhance revenues of The University of Texas MD Anderson Cancer Center by establishing joint ventures in selected markets, providing additional referrals to the institution, contracting for delivery of inpatient and out-patient management, using existing UT MD Anderson Cancer Center reference laboratory services, and fostering additional philanthropy in distant areas.
Clark L. Anderson
1. The Fcγ Receptor (FcγR) family of molecules. Anderson's early work on identifying and characterizing the high affinity FcγRI and low affinity FcγRII for IgG on human monocytes and other cells was aided by his development of monoclonal antibodies (mab) to both of these receptors, mab 32.2 (US Patent US4954617A awarded in 1990) to the former in collaboration with Michael Fanger and Paul Guyre, and mab IV.3 to the latter in collaboration with R. John Looney. To facilitate the clinical application of these antibodies, Anderson enabled the establishment by Fanger and Guyre of Medarex, Inc., a biotech company since acquired by Bristol-Myers Squibb for 2.4 billion $US. Further studies by Anderson showed FcRI to be associated with the FcRγ chain, and that both receptors upon clustering mediated intracellular kinase cascades that triggered various biological effects. This early work catalyzed an avalanche of studies that have allowed the elaboration of the FcγR family of proteins, now known to consist of several genes (8 in human, 5 in mouse), over 20 transcripts, and at least 9 expressed protein receptors; further, it has become clear that clustering of these receptors results in a variety of biological effects such as superoxide and cytokine output, cell-mediated killing, endocytosis, all resulting in removal of the antigen and perversely in disease-causing auto-immune effects.