Chameleon (comics)
Created by writer Stan Lee and artist Steve Ditko, the character first appeared in "The Amazing Spider-Man" #1 (March 1963), making him the first member of Spider-Man's rogues' gallery, based on issue publication date, excluding the burglar who murdered Ben Parker (Supercharger was the first Spider-Man supervillain chronologically). He is also well known to be related to Kraven the Hunter. That revealed relationship helped evolve him as a major villain compared to his original depiction of being just a solo villain in the original issue of "The Amazing Spider-Man".
Mortal Kombat Trilogy
Two new secret characters appear as well, depending on the version of the game. Most versions have Chameleon, a semi-visible ninja who rapidly switches between all the other male ninja (Classic Sub-Zero, Scorpion, Noob Saibot, Human Smoke, Rain, Reptile, and Ermac) during combat. This character is playable by performing a special button combination. The Nintendo 64 version replaced him with the female equivalent named Khameleon, who switched between the other female ninja instead.