Orientia tsutsugamushi
"O. tsutsugamushi" causes a complex and dangerous infection scrub typhus. Infection starts when chiggers bite on the skin during their feeding. The bacteria are deposited at the site of feeding (inoculation), where they multiply. They cause progressive tissue damage (necrosis). Necrosis progresses to inflammation of the blood vessels called vasculitis. This in turn causes inflammation of the lymph nodes, called lymphadenopathy. Within a few days, vasculitis extends to various organs including liver, brain, kidney, meninges and the lung. The disease is responsible for nearly a quarter of all the febrile (high fever) illness in endemic areas. Mortality in severe case or due to improper treatment or misdiagnosis may be as high as 30-70%. About 6% of infected people die untreated, and 1.4% of the patients die even with medical treatment. Moreover, death rate can be as high as 13% where medical treatment is not properly handled. In cases of misdiagnosis and failure of treatment, systemic complications rapidly develop including acute respiratory distress syndrome, acute kidney failure, encephalitis, gastrointestinal bleeding, hepatitis, meningitis, myocarditis, pancreatitis, pneumonia, septic shock, sub-acute thyroiditis, and multi-organ dysfunctions. Harmful symptoms involving multiple organ failure and neurological impairment are difficult to treat, and can be lifelong debilitation or directly fatal. The central nervous system is often affected and result in various complications including cerebellitis, cranial nerve palsies, meningoencephalitis, plexopathy, transverse myelitis, neuroleptic malignant syndrome, and Guillan-Barré syndrome. Death rates due to complications can be up to 14% in brain infections, and 24% with multiple organ failure. It is the major cause of acute encephalitis syndrome in India, where viral infection Japanese encephalitis has been regarded as the main factor.
List of Deadman Wonderland characters
Dr. Rei Takashima is a physician who works at Deadman Wonderland. She was charged with the duty of removing the specific parts of the Deadmen that lose in Carnival Corpse and had survived (she removes the parts without applying anesthetic to the Deadman). Of course Rei also becomes enraged when she doesn't get to remove a non-regenerative organ as seen when Nagi had secretly rigged the macabre slot machine so that she would have to cut off Minatsuki's hair. Rei was the one who told Ganta about the live-saving candy after Tamaki collapsed the tower on Ganta and Rei patched Ganta up. After Senji was defeated by Ganta, Rei showed off her sadistic side when she was ordered to remove Senji's right eye. Rei later helped Tamaki with his experiment that involved the Forgeries where she gave Azami Midō her Snake Branch of Sin, making her a Forgery. She even experimented on Ganta after Tamaki had the Forgeries bring Ganta to him. While in her laboratory near the end of the "Revolt Arc," Rei is killed by an unknown being (most likely the Wretched Egg).
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