Orientia tsutsugamushi
"O. tsutsugamushi" causes a complex and dangerous infection scrub typhus. Infection starts when chiggers bite on the skin during their feeding. The bacteria are deposited at the site of feeding (inoculation), where they multiply. They cause progressive tissue damage (necrosis). Necrosis progresses to inflammation of the blood vessels called vasculitis. This in turn causes inflammation of the lymph nodes, called lymphadenopathy. Within a few days, vasculitis extends to various organs including liver, brain, kidney, meninges and the lung. The disease is responsible for nearly a quarter of all the febrile (high fever) illness in endemic areas. Mortality in severe case or due to improper treatment or misdiagnosis may be as high as 30-70%. About 6% of infected people die untreated, and 1.4% of the patients die even with medical treatment. Moreover, death rate can be as high as 13% where medical treatment is not properly handled. In cases of misdiagnosis and failure of treatment, systemic complications rapidly develop including acute respiratory distress syndrome, acute kidney failure, encephalitis, gastrointestinal bleeding, hepatitis, meningitis, myocarditis, pancreatitis, pneumonia, septic shock, sub-acute thyroiditis, and multi-organ dysfunctions. Harmful symptoms involving multiple organ failure and neurological impairment are difficult to treat, and can be lifelong debilitation or directly fatal. The central nervous system is often affected and result in various complications including cerebellitis, cranial nerve palsies, meningoencephalitis, plexopathy, transverse myelitis, neuroleptic malignant syndrome, and Guillan-Barré syndrome. Death rates due to complications can be up to 14% in brain infections, and 24% with multiple organ failure. It is the major cause of acute encephalitis syndrome in India, where viral infection Japanese encephalitis has been regarded as the main factor.
Sonya Blade
In "", while on an assignment in the East, Sonya received a distressing message from Jax that the OIA had been destroyed by an accomplice of Shang Tsung and Quan Chi. She was then visited by Raiden, who asked for her aid against the Deadly Alliance and instructed her to meet with the other heroes on Shang Tsung's abandoned island, where she developed a small rivalry with Frost. To earn the right to pass into Outworld, each warrior had to defeat a representation of his or her adversary; to her surprise, it was a stranger with an image of a red dragon on his back. Sonya was unable to find the missing OIA agents Cyrax and Kenshi, and was killed along with Jax, Cage, Kung Lao and Kitana in battle with the Deadly Alliance's Tarkatan forces. The Deadly Alliance's victory was short-lived, as Onaga reclaimed Outworld, as well as the amulet. With his ability to raise the dead at will, he resurrected Sonya and her fallen comrades, who then served as his slaves until their souls were freed by Liu Kang and Ermac.