U.S. Route 101
The nearly highway's northern terminus is in Tumwater, Washington: the route remains along the Olympic Peninsula's coastal perimeter west, north, and east; the northernmost point on the highway is in Port Angeles. The southern terminus of US 101 is in Los Angeles at the East Los Angeles Interchange, the world's busiest freeway interchange.
Alabama State Route 101
SR 101 begins at an intersection with CR 460 west of Moulton, in Lawrence County. This intersection is just west-southwest of Town Creek Cemetery. It travels to the north and intersects SR 24. It curves to the north-northwest and intersects the western terminus of CR 114. The highway intersects the northern terminus of CR 50 and curves to the north-northeast. It has a one-block concurrency with CR 128. SR 101 meets the northern terminus of CR 127. Then, it intersects the eastern terminus of CR 343. The highway curves to the northeast and intersects the western terminus of CR 157. It curves to a nearly due north direction and intersects the eastern terminus of CR 131. SR 101 enters Hatton. There, it passes Hatton High School and has a one-block concurrency with CR 236. Upon leaving Hatton, SR 101 intersects the western terminus of CR 156 and the southern terminus of CR 147, which are one block apart. The highway curves to the northwest and crosses over Watches Creek. After it curves to the north-northwest, it intersects the eastern terminus of CR 146. It then curves to the north-northeast and intersects SR 157 (University of North Alabama Highway). Then, it intersects CR 136. One block later is the eastern terminus of CR 255. The highway crosses over Beck Creek and intersects the western terminus of CR 589 just before curving back to the north-northwest. After curving to the northeast, it intersects the western terminus of CR 258 and then the eastern terminus of CR 259. At the beginning of a curve to the northwest is an intersection with the southern terminus of CR 262. The highway curves to the north-northeast and enters Town Creek. It crosses over Tucker Branch and intersects the eastern terminus of CR 143. Just before heading north, SR 101 intersects the northern terminus of CR 261 (Brooks Spring Road). It intersects the eastern terminus of CR 141 and the eastern terminus of CR 267. In the main part of Town Creek, is an intersection with US 72 Alt./SR 20 and a crossing of Warren Branch. Just before leaving the city limits of Town Creek, the highway intersects the southern terminus of CR 216. It crosses over Meadow Branch. It then intersects the western terminus of CR 269 and the eastern terminus of CR 268 before meeting CR 406. After an intersection with the eastern terminus of CR 404, SR 101 passes Mathews Cemetery. It then intersects the eastern terminus of SR 184 and the northern terminus of CR 270 before reaching CR 314 (Foster Mill Road). SR 101 curves to the northeast and crosses over Big Nance Creek. Immediately after that crossing, it travels through the southern and southeastern parts of Joe Wheeler State Park. Just before leaving the park, it intersects CR 150 and CR 414 in close succession. The highway curves to the north-northwest and travels through Wheeler Dam Village. It then crosses over the Tennessee River on top of Wheeler Dam. This crossing marks the Lauderdale County line.