History of Haiti
Following the arrival of Europeans, La Hispaniola's indigenous population suffered greatly to near extinction, in possibly the worst case of depopulation in the Americas. A commonly accepted hypothesis attributes the high mortality of this colony in part to European diseases to which the natives had no immunity. A small number of Taínos were able to survive and set up villages elsewhere. Spanish interest in Hispaniola began to wane in the 1520s, as more lucrative gold and silver deposits were found in Mexico and South America. Thereafter, the population of Spanish Hispaniola grew at a slow pace.
Hispaniola
Under Nicolás de Ovando y Cáceres' governorship, the Indians were made to work in the gold mines. By 1503, the Spanish Crown legalized the distribution of Indians to work the mines as part of the encomienda system. Once the Indians entered the mines, they were often wiped out by hunger and difficult conditions. By 1508, the Taíno population of about 400,000 was reduced to 60,000, and by 1514, only 26,334 remained. About half resided in the mining towns of Concepcion, Santiago, Santo Domingo, and Buenaventura. The repartimiento of 1514 accelerated emigration of the Spanish colonists, coupled with the exhaustion of the mines. The first documented outbreak of smallpox, previously an Eastern hemisphere disease, occurred on Hispaniola in December 1518 among enslaved African miners. Some scholars speculate that European diseases arrived before this date, but there is no compelling evidence for an outbreak. The natives had no immunity to European diseases, including smallpox. By May 1519, as many as one-third of the remaining Taínos had died.