History of the East–West Schism
Disunion in the Roman Empire further contributed to disunion in the Church. The Emperor Diocletian famously divided the administration of the eastern and western portions of the Empire in the early 4th century, though subsequent leaders (including Constantine) aspired to and sometimes gained control of both regions. Theodosius the Great, who established Nicene Christianity as the official religion of the Roman Empire (see Edict of Thessalonica), was the last Emperor to rule over a united Roman Empire. Following his death in 395, the division into western and eastern halves, each for a few decades still under its own Emperor, was never reunited.
Constantine VI
Constantine VI was the final ruler to be universally recognized as Roman Emperor, being recognized as such by both the Empire which he ruled in the east, the papacy and the Western European powers over which the pope held suzerainty. With his mother becoming Empress regnant upon his deposition, the papacy crowned Charlemagne as a new Emperor in Western Europe, asserting that a woman could not be Empress in her own right. This laid the foundations of a new polity, independent of the East, that would evolve into the "Holy Roman Empire".