Chameleon (comics)
Created by writer Stan Lee and artist Steve Ditko, the character first appeared in "The Amazing Spider-Man" #1 (March 1963), making him the first member of Spider-Man's rogues' gallery, based on issue publication date, excluding the burglar who murdered Ben Parker (Supercharger was the first Spider-Man supervillain chronologically). He is also well known to be related to Kraven the Hunter. That revealed relationship helped evolve him as a major villain compared to his original depiction of being just a solo villain in the original issue of "The Amazing Spider-Man".
Question (comics)
The Question's specialized belt buckle, which releases a binary gas that binds his mask to his skin and temporarily recolors his garb and hair, is similar to that of the Spider-Man villain Chameleon. In his initial appearances, which were drawn by Steve Ditko, the Chameleon had used a device in a belt buckle which emitted a transformation-enhancing gas. The binding element is adjusted to Sage's specific body chemistry.