Obsessive–compulsive disorder
A form of psychotherapy called "cognitive behavioral therapy" (CBT) and psychotropic medications are first-line treatments for OCD. Other forms of psychotherapy, such as psychodynamic and psychoanalysis may help in managing some aspects of the disorder, but in 2007 the American Psychiatric Association (APA) noted a lack of controlled studies showing their effectiveness "in dealing with the core symptoms of OCD". The fact that many individuals do not seek treatment may be due in part to stigma associated with OCD.
Harris Isbell
the clinical use of opiate antagonists (e.g., nalorphine/Nalline and naloxone/Narcan) as treatment for opiate overdoses, 
the ability of methadone to alleviate opiate withdrawal symptoms,
rapid tolerance but lack of physical dependence with LSD,
cross-tolerance between LSD and psilocybin,
and the ability of pure THC to cause marijuana-like effects.
New pharmaceutical substances were assayed (in the prisoner population) for their abuse and addiction (substance dependence) potential (medications for pain, cough, and diarrhea were of particular concern), and this information was utilized by groups such as the World Health Organization.