Christopher Columbus
Since the late 20th century, historians have criticized Columbus for initiating colonization and for abuse of natives. Among reasons for this criticism is the poor treatment of the native Taíno people of Hispaniola, whose population declined rapidly after contact with the Spanish. Columbus required the natives to pay tribute in gold and cotton. Modern estimates for the pre-Columbian population of Hispaniola are around 250,000–300,000. According to the historian Gonzalo Fernandez de Oviedo y Valdes, by 1548, 56 years after Columbus landed, and 42 years after he died, fewer than 500 Taíno were living on the island. The indigenous population declined rapidly, due primarily to the first pandemic of European endemic diseases, which struck Hispaniola after 1519. The natives had no acquired immunity to these new diseases and suffered high fatalities. There is also documentation that they were overworked.
Spanish colonization of the Americas
Columbus made four voyages to the West Indies as the monarchs granted Columbus the governorship of the new territories, and financed more of his trans-Atlantic journeys. He founded La Navidad on the island later named Hispaniola (now divided into Haiti and the Dominican Republic), in what is the present-day Haiti on his first voyage. After its destruction by the indigenous Taino people, the town of Isabella was begun in 1493, on his second voyage. In 1496 his brother, Bartholomew, founded Santo Domingo. By 1500, despite a high death rate, there were between 300 and 1000 Spanish settled in the area. The local Taíno people continued to resist, refusing to plant crops and abandoning their Spanish-occupied villages. The first mainland explorations were followed by a phase of inland expeditions and conquest. In 1500 the city of Nueva Cádiz was founded on the island of Cubagua, Venezuela, followed by the founding of Santa Cruz by Alonso de Ojeda in present-day Guajira peninsula. Cumaná in Venezuela was the first permanent settlement founded by Europeans in the mainland Americas, in 1501 by Franciscan friars, but due to successful attacks by the indigenous people, it had to be refounded several times, until Diego Hernández de Serpa's foundation in 1569. The Spanish founded San Sebastian de Uraba in 1509 but abandoned it within the year. There is indirect evidence that the first permanent Spanish mainland settlement established in the Americas was Santa María la Antigua del Darién.