IPLEDGE program
Although the goal of the program is to prevent pregnancies of women who take the drug, male patients must also participate in anti-pregnancy restrictions, primarily due to fears that male isotretinoin users might share their prescriptions with females without their physicians' knowledge. There has been no link to birth defects from Accutane associated with males using the drug, though male sexual dysfunction has been suggested by one study. As this has not been conclusively proven, this is not acknowledged as a side effect in the official literature accompanying the medication.
Tijuana
Tijuana has many pharmacies that target visitors from the United States, which sell some medicines without prescriptions and/or at much lower costs than in the U.S. Many medications still require a Mexican prescription, which can be obtained from adjacent doctors' offices. People filling up prescriptions for drugs classified in the US as Schedule II or Schedule III have found it more difficult to locate such medications, and the purchase of pseudoephedrine also has become restricted by Tijuana pharmacies, just as in the U.S. To fill a prescription in Tijuana for any drug covered by the US Controlled Substances Act and legally bring it into the United States requires a prescription from the United States for re-import. Americans can import up to a 90-day supply of non-controlled medications for personal use to the USA from Mexico and other countries.