Christopher Columbus
Since the late 20th century, historians have criticized Columbus for initiating colonization and for abuse of natives. Among reasons for this criticism is the poor treatment of the native Taíno people of Hispaniola, whose population declined rapidly after contact with the Spanish. Columbus required the natives to pay tribute in gold and cotton. Modern estimates for the pre-Columbian population of Hispaniola are around 250,000–300,000. According to the historian Gonzalo Fernandez de Oviedo y Valdes, by 1548, 56 years after Columbus landed, and 42 years after he died, fewer than 500 Taíno were living on the island. The indigenous population declined rapidly, due primarily to the first pandemic of European endemic diseases, which struck Hispaniola after 1519. The natives had no acquired immunity to these new diseases and suffered high fatalities. There is also documentation that they were overworked.
Alonso de Ojeda
The flotilla arrived at Bahia de Calamar in present-day Cartagena (Colombia). This was against the wishes of De la Cosa who did not want to land in the area. After disembarking with about 70 men Ojeda encountered a number of indigenous tribes. He then sent out missionaries and interpreters to read out the proclamation that had been drafted by Palacios Rubios. The indigenous people were upset by this proclamation and so Ojeda tried to placate them by offering them trinkets. At this time the Spanish were also raiding villages to capture Indians for slaves. Ojeda was no exception to the cruelty of the Spanish against the native people. An eyewitness account recorded by historian Bartolomé de las Casas notes, "The Spaniards worked an incredible slaughter on that village, they spared no one, women, children, babies or not. Then they robbed." These actions so provoked the indigenous people that they started to fight against the Spanish settlers. Ojeda defeated the natives in the coastal area and on pursuing some of the survivors who had escaped into the jungle he came upon the village of Turbaco. The Spanish were then taken by surprise by a counterattack. Nearly the entire party were wiped out in the battle and Juan de la Cosa sacrificed his life so that Ojeda could escape. Only one other Spanish soldier survived the battle and he and Ojeda fled back to the coast where they were rescued by the ships anchored in the bay.