Indigenous peoples of the Caribbean
The Classic Taíno lived in eastern Cuba, Hispaniola, and Puerto Rico. They spoke a dialect called Classic Taíno. Compared to their neighbors, the Classic Taíno had substantially developed agricultural societies. Puerto Rico was divided into twenty chiefdoms which were organized into one united kingdom or confederation, Borinquen. Hispaniola was divided into roughly 45 chiefdoms, which were organized into five kingdoms under the leadership of the chief of each area's premier chiefdom. Beginning around 1450, Classic Taíno from Hispaniola began migrating to eastern Cuba; they are conventionally known as the Cuban Taíno. The Cuban Taíno gained power over some of Cuba's earlier Western Taíno inhabitants, the Ciboney, but no regional or island-wide political structure had developed on the island at the time of Spanish colonization of the Americas.
Cueva people
The Cueva were an indigenous people who lived in the Darién region of eastern Panama. They were completely exterminated between 1510 and 1535 by the effects of Spanish colonization. Following the massacre of the Cueve, the island of Isla Chuche (later changed to Isla Pedro Gonzalez and now known as Pearl Island) was populated by African slaves, imported there by the Spaniards to search for pearls.