Asia
The coastal periphery was home to some of the world's earliest known civilizations, each of them developing around fertile river valleys. The civilizations in Mesopotamia, the Indus Valley and the Yellow River shared many similarities. These civilizations may well have exchanged technologies and ideas such as mathematics and the wheel. Other innovations, such as writing, seem to have been developed individually in each area. Cities, states and empires developed in these lowlands.
Macedonia (Greece)
Macedonia lies at the crossroads of human development between the Aegean and the Balkans. The earliest signs of human habitation date back to the palaeolithic period, notably with the Petralona cave in which was found the oldest yet known European humanoid, "Archanthropus europaeus petraloniensis". In the Late Neolithic period (c. 4500 to 3500 BC), trade took place with quite distant regions, indicating rapid socio-economic changes. One of the most important innovations was the start of copper working.