Mona Lisa
The painting is thought to be a portrait of Lisa Gherardini, the wife of Francesco del Giocondo, and is in oil on a white Lombardy poplar panel. It had been believed to have been painted between 1503 and 1506; however, Leonardo may have continued working on it as late as 1517. Recent academic work suggests that it would not have been started before 1513. It was acquired by King Francis I of France and is now the property of the French Republic, on permanent display at the Louvre Museum in Paris since 1797.
Lego in popular culture
A 2011 exhibition titled "Da Vinci, The Genius" at the Frazier History Museum in Louisville, Kentucky attracted attention by having a "Brick Art" Mona Lisa replica constructed by Lego artist Brian Korte. 
Lego builders such as Eric Harshbarger have made multiple replicas of Mona Lisa. 
Matching the approximate 21 by 30 inch size (535 x 760+ mm) of Leonardo's original requires upwards of 5,000 standard Lego "bricks", but replicas measuring 6 by 8 feet have been built, requiring more than 30,000 bricks. 
The Little Artists (John Cake and Darren Neave) have created an entire Modern Art collection in Lego form. Their exhibition 'Art Craziest Nation'
was shown at the Walker Art Gallery in Liverpool, UK.