Cat intelligence
The brain of the domesticated cat is about long, and weighs . If a typical cat is taken to be long with a weight of , then the brain would be at 0.91% of its total body mass, compared to 2.33% of total body mass in the average human. Within the encephalization quotient proposed by Jerison in 1973, values above 1 are classified big brained, while values lower than 1 are small brained. The domestic cat is attributed a value of between 1–1.71 relative to human value that is 7.44–7.8. The largest brains in the Felidae family are those of the tigers in Java and Bali, of which the largest relative brain size within the "panthera" is the "tigris". It is debated whether there exists a causal relationship between brain size and intelligence in vertebrates. Correlations have been shown between these factors in a number of experiments. However, correlation does not imply causation. Most experiments involving the relevance of brain size to intelligence hinge on the assumption that complex behavior requires a complex (and therefore intelligent) brain; however, this connection has not been consistently demonstrated.
Microcephaly
Microcephaly generally is due to the diminished size of the largest part of the human brain, the cerebral cortex, and the condition can arise during embryonic and fetal development due to insufficient neural stem cell proliferation, impaired or premature neurogenesis, the death of neural stem cells or neurons, or a combination of these factors. Research in animal models such as rodents has found many genes that are required for normal brain growth. For example, the Notch pathway genes regulate the balance between stem cell proliferation and neurogenesis in the stem cell layer known as the ventricular zone, and experimental mutations of many genes can cause microcephaly in mice, similar to human microcephaly. Mutations of the abnormal spindle-like microcephaly-associated (ASPM) gene are associated with microcephaly in humans and a knockout model has been developed in ferrets that exhibits severe microcephaly. In addition, viruses such as cytomegalovirus (CMV) or Zika have been shown to infect and kill the primary stem cell of the brain—the radial glial cell, resulting in the loss of future daughter neurons. The severity of the condition may depend on the timing of infection during pregnancy.