Arachne
It has also been suggested that Jeremias Gotthelf's nineteenth century novella, "The Black Spider", was heavily influenced by the Arachne story from Ovid's "Metamorphoses". In the novella, a woman is turned into a venomous spider having reneged on a deal with the devil.
Kaine Parker
During the "Spider Island" storyline, Kaine is further mutated by the Jackal into a hulking spider-like creature: a man's body, with a spider head, covered head to toe in spider hair, with 4 spider legs projecting from his back. The Jackal makes him the first of his army of individuals to use and is dubbed "Tarantula" during Spider-Island.