U.S. Route 101
The nearly highway's northern terminus is in Tumwater, Washington: the route remains along the Olympic Peninsula's coastal perimeter west, north, and east; the northernmost point on the highway is in Port Angeles. The southern terminus of US 101 is in Los Angeles at the East Los Angeles Interchange, the world's busiest freeway interchange.
Kentucky Route 101
KY 101 follows Main Street through the city, in the center of which the highway intersects CSX's Main Line Subdivision rail line. KY 101 continues through the Smiths Grove Historic District. The highway passes a block to the east of the J.L. Wright House and a block to the west of Smiths Grove Presbyterian Church. KY 101 passes the Smiths Grove Baptist Church one block south of where the route turns west onto 6th Street for two blocks. At the west city limit of Smiths Grove, the highway turns north and leaves the city along Smiths Grove-Scottsville Road. KY 101 passes through a pair of more-than-right-angle curves to the west and then north before reaching US 31W (Louisville Road), which the state-numbered highway joins heading west.