Chameleon (comics)
Created by writer Stan Lee and artist Steve Ditko, the character first appeared in "The Amazing Spider-Man" #1 (March 1963), making him the first member of Spider-Man's rogues' gallery, based on issue publication date, excluding the burglar who murdered Ben Parker (Supercharger was the first Spider-Man supervillain chronologically). He is also well known to be related to Kraven the Hunter. That revealed relationship helped evolve him as a major villain compared to his original depiction of being just a solo villain in the original issue of "The Amazing Spider-Man".
Uncanny X-Men
For the remainder of the decade the X-Men fight enemies such as Stephen Lang and his Sentinels, Magneto, Banshee's cousin Black Tom and the Juggernaut, the Shi'ar Erik the Red and the Imperial Guard, Arcade, Wolverine's former colleagues, Canadian superhero team Alpha Flight, and MacTaggert's son Proteus. In 2010, Comics Bulletin ranked Claremont and Byrne's run on "The X-Men" second on its list of the "Top 10 1970s Marvels".