Organophosphate poisoning
Organophosphate pesticides are one of the top causes of poisoning worldwide, with an annual incidence of poisonings among agricultural workers varying from 3-10% per country.
Tris(1,3-dichloro-2-propyl)phosphate
Organophosphate toxicity is classically associated with acetylcholinesterase inhibition. Acetylcholinesterase is an enzyme responsible for breaking down the neurotransmitter acetylcholine. Many organophosphates, especially those designed to act as nerve agents or pesticides, bind with the active site on acetylcholinesterase, preventing it from breaking down acetylcholine. In rodent studies, TDCPP was found to have very low capacity to inhibit acetylcholinesterase, and it is considered to have low acute toxicity. Animals that were given very high doses (>1 g/kg/day) exhibited clinical signs of organophosphate poisoning, including muscle weakness, loss of coordination, hyperactivity, and death.