Oxytocin
It has been shown that oxytocin differentially affects males and females. Females who are administered oxytocin are overall faster in responding to socially relevant stimuli than males who received oxytocin. Additionally, after the administration of oxytocin, females show increased amygdala activity in response to threatening scenes; however, males do not show increased amygdala activation. This phenomenon can be explained by looking at the role of gonadal hormones, specifically estrogen, which modulate the enhanced threat processing seen in females. Estrogen has been shown to stimulate the release of oxytocin from the hypothalamus and promote receptor binding in the amygdala.
Human bonding
A study in 2003, by the U.S. Department of Defense, based on human-animal bonding determined that there was an improvement and enrichment of life when animals were closely involved with humans. The study tested blood levels and noticed a rise in Oxytocin in humans and animals which participated; Oxytocin has the ability to lower stress, heart rate, and fear levels in humans and animals.