Hydrogen bond
Hydrogen bonds can vary in strength from weak (1–2 kJ mol) to strong (161.5 kJ mol in the ion ). Typical enthalpies in vapor include:
Hydrogen bond
A protein backbone hydrogen bond incompletely shielded from water attack is a dehydron. Dehydrons promote the removal of water through proteins or ligand binding. The exogenous dehydration enhances the electrostatic interaction between the amide and carbonyl groups by de-shielding their partial charges. Furthermore, the dehydration stabilizes the hydrogen bond by destabilizing the nonbonded state consisting of dehydrated isolated charges.