Organophosphate poisoning
Organophosphate pesticides are one of the top causes of poisoning worldwide, with an annual incidence of poisonings among agricultural workers varying from 3-10% per country.
Organophosphorus acid anhydrolase
OPAA’s susbstrate-specificity to organophosphorus-containing compounds, especially fluoride-containing G-type nerve agents such as sarin, cyclosarin, tabun, and soman, have drawn the interest of the U.S. Army . That attention has resulted in the establishment of a biodegradation program in search of safe and effective means of disposal for chemical weapons in the 1980s; the program is currently called the Advanced Catalytic Enzyme System (ACES).