2008 Orange Bowl
In the wake of the Hokies's defeat, Virginia Tech chose to start a new quarterback and a new offensive plan. Behind freshman Tyrod Taylor, the Hokies rolled to five straight victories, including a win over No. 22 Clemson by 18 points. During the winning streak, Sean Glennon, who had started at quarterback for the Hokies during the first two games of the season, returned to alternate possessions with Taylor in an unusual two-quarterback system. On October 25, the Hokies had a chance to make up for their early-season loss to LSU when they faced No. 2 Boston College on a Thursday night in Blacksburg, Virginia. Though the Hokies dominated for most of the game, Boston College quarterback Matt Ryan managed a late-game comeback to win the game 14–10 with 11 seconds remaining.
2008 Orange Bowl
Kansas, meanwhile, was less-highly regarded on defense and came into the 2008 Orange Bowl ranked 57th nationally in pass defense. On the ground, however, Kansas was ranked far higher, sixth in the nation. In addition, Kansas only allowed an average of 16 points per game, good enough for to be ranked fourth nationally. A key portion of that run defense was defensive tackle James McClinton, who was named the Big 12's Defensive Lineman of the Year and earned second-team All-America honors. McClinton finished the 2007 regular season with 10.5 tackles for loss and promised more of the same for the Orange Bowl. The team captain of the Jayhawk defense, meanwhile, was All-American cornerback Aqib Talib. Talib was also a threat on offense, catching eight passes, including four touchdowns, during the regular season.