Chameleon (comics)
Created by writer Stan Lee and artist Steve Ditko, the character first appeared in "The Amazing Spider-Man" #1 (March 1963), making him the first member of Spider-Man's rogues' gallery, based on issue publication date, excluding the burglar who murdered Ben Parker (Supercharger was the first Spider-Man supervillain chronologically). He is also well known to be related to Kraven the Hunter. That revealed relationship helped evolve him as a major villain compared to his original depiction of being just a solo villain in the original issue of "The Amazing Spider-Man".
Kraven the Hunter
He is contacted by his half-brother Chameleon to defeat Spider-Man. He leads Spider-Man to Central Park with the help of Chameleon, who disguises himself as Kraven to use himself as a decoy while the real Kraven ambushes the hero. However, despite Kraven having weakened Spider-Man with a poisonous dart, Spider-Man prevails in the end. Spider-Man proves a frustrating quarry because Kraven continually underestimates the superhero's resourcefulness.