U.S. Route 101
The nearly highway's northern terminus is in Tumwater, Washington: the route remains along the Olympic Peninsula's coastal perimeter west, north, and east; the northernmost point on the highway is in Port Angeles. The southern terminus of US 101 is in Los Angeles at the East Los Angeles Interchange, the world's busiest freeway interchange.
Kentucky Route 101
KY 101 begins at KY 100 in Scottsville's courthouse square within the Scottsville Downtown Commercial Historic District. KY 100 heads east along Main Street and south on Court Street. KY 101 heads north from downtown along Court Street. North of Plum Street on the northern edge of the street grid, the highway's name becomes Smiths Grove Road. KY 101 leaves the city of Scottsville immediately before its intersection with US 31E (New Glasgow Road), which bypasses the city to the west and north. North of the U.S. Highway, the route meets the eastern end of KY 1332 (Halifax Road) and crosses Bays Fork and the North Prong of Bays Fork. KY 101 meets the east end of KY 234 (Cemetery Road) as it passes to the west of Gainesville. The highway intersects KY 1533 (Meadow-Port Oliver Road) at Meador before the route crosses the Barren River into Warren County.
KY 101 continues as Smiths Grove-Scottsville Road, which passes to the northeast of Martinsville and meets the east end of KY 1402 (Porter Pike) at Three Forks. The highway intersects KY 1297 (Gotts Hydro Road) at Kepler. KY 101 intersects US 68 and KY 80, which run concurrently on Glasgow Road, south of KY 101's diamond interchange with I-65 (Abraham Lincoln Memorial Highway) at the southern edge of the city of Smiths Grove. The portion of KY 101 between US 68 and I-65 is the most heavily traveled portion of KY 101; as of 2015, this segment's annual average daily traffic is more than three times that of the portion of the highway between KY 1297 and US 68. Since I-65's interchange with US 68 is partial, traffic from southbound I-65 to westbound US 68 and from eastbound US 68 to northbound I-65 must use KY 101 to connect.