Arachne
It has also been suggested that Jeremias Gotthelf's nineteenth century novella, "The Black Spider", was heavily influenced by the Arachne story from Ovid's "Metamorphoses". In the novella, a woman is turned into a venomous spider having reneged on a deal with the devil.
Carlie Cooper
During the "Secret Wars" storyline, a variation of Carlie Cooper resides on the Battleworld domain of Spider-Island. Carlie was mutated into a spider monster alongside Mary Jane, Betty Brant, and Sharon Carter by the Spider Queen and used as bait by the heroes. Spider-Man, Agent Venom, and Iron Goblin use Curt Connors' Lizard Formula to mutate the ladies into lizards, but free their minds from the Spider Queen's control. Carlie later joined the Reistance into attacking the Spider Queen's lair.