Arachne
It has also been suggested that Jeremias Gotthelf's nineteenth century novella, "The Black Spider", was heavily influenced by the Arachne story from Ovid's "Metamorphoses". In the novella, a woman is turned into a venomous spider having reneged on a deal with the devil.
Shathra
Shathra is an insectoid creature from the Astral Plane and the totem of the spider wasp, much as Spider-Man is rumored to be a totem of the spider. As spider wasps kill spiders, she escaped the astral world where she lived to find Spider-Man (Spider-Man had previously visited her world and accidentally alerted her to his presence). Her plan was to feed "the spider" to her children once she killed him.