Chameleon (comics)
Created by writer Stan Lee and artist Steve Ditko, the character first appeared in "The Amazing Spider-Man" #1 (March 1963), making him the first member of Spider-Man's rogues' gallery, based on issue publication date, excluding the burglar who murdered Ben Parker (Supercharger was the first Spider-Man supervillain chronologically). He is also well known to be related to Kraven the Hunter. That revealed relationship helped evolve him as a major villain compared to his original depiction of being just a solo villain in the original issue of "The Amazing Spider-Man".
Chameleon (comics)
The Chameleon inspired Kraven to begin hunting Spider-Man, inviting Kraven to dispose of the hero. With Kraven, the Chameleon battled Iron Man, and then confronted the Hulk. At one point, the Chameleon disguised himself as Hank Pym, and robbed Pym's laboratory for documents to combat Virus Nine. While delivering the documents and a shrunken Hulk to HYDRA, he was encountered and defeated by Ant-Man. The Chameleon disguised himself as the Torpedo and battled Daredevil.