Chameleon (comics)
Created by writer Stan Lee and artist Steve Ditko, the character first appeared in "The Amazing Spider-Man" #1 (March 1963), making him the first member of Spider-Man's rogues' gallery, based on issue publication date, excluding the burglar who murdered Ben Parker (Supercharger was the first Spider-Man supervillain chronologically). He is also well known to be related to Kraven the Hunter. That revealed relationship helped evolve him as a major villain compared to his original depiction of being just a solo villain in the original issue of "The Amazing Spider-Man".
Hela (comics)
Conflict with various forces brought Bruce Banner, a.k.a. the Hulk, and Agamemnon, the leader of the Pantheon, to Hela's realm. After an undetermined time fighting Hela's skeletal forces, Agamemnon pleaded, based on a vaguely hinted upon relationship, to allow the two to leave. Hela relented, reluctantly.