Isotretinoin
Isotretinoin is a teratogen; there is about a 20–35% risk for congenital defects in infants exposed to the drug "in utero", and about 30–60% of children exposed to isotretinoin prenatally have been reported to show neurocognitive impairment. Because of this, there are strict controls on prescribing isotretinoin to women who may become pregnant and women who become pregnant while taking isotretinoin are strongly advised to terminate their pregnancies.
Fluticasone
Fluticasone is a synthetic glucocorticoid which is used to treat nasal symptoms. Both the furoate and propanoate esters, fluticasone furoate and fluticasone propionate, are also used as topical anti-inflammatories and inhaled corticosteroids, and are used much more commonly in comparison.
In the United States the wholesale cost per spray is about 0.33 USD as of 2018. In 2016 it was the 16th most prescribed medication in the United States with more than 29 million prescriptions.