U.S. Route 101
The nearly highway's northern terminus is in Tumwater, Washington: the route remains along the Olympic Peninsula's coastal perimeter west, north, and east; the northernmost point on the highway is in Port Angeles. The southern terminus of US 101 is in Los Angeles at the East Los Angeles Interchange, the world's busiest freeway interchange.
Massachusetts Route 101
From Templeton, Route 101 enters the city of Gardner, acting as one of the main streets through town. For two blocks west of Main Street, Route 101 runs concurrently with Route 68. The route crosses Route 140 before entering Ashburnham. In Ashburnham, Route 101 heads into the center of town, sharing a short concurrency along Route 12 before turning northward, passing by Winnekeag Lake and west of Ward Pond before ending at Route 119, three miles south of the New Hampshire state line and 300 yards east of the Ashby town line.