History of the East–West Schism
Disunion in the Roman Empire further contributed to disunion in the Church. The Emperor Diocletian famously divided the administration of the eastern and western portions of the Empire in the early 4th century, though subsequent leaders (including Constantine) aspired to and sometimes gained control of both regions. Theodosius the Great, who established Nicene Christianity as the official religion of the Roman Empire (see Edict of Thessalonica), was the last Emperor to rule over a united Roman Empire. Following his death in 395, the division into western and eastern halves, each for a few decades still under its own Emperor, was never reunited.
Christianity in the 4th century
Disunion in the Roman Empire further contributed to disunion in the Church. Emperor Diocletian divided the administration of the eastern and western portions of the empire in the early 4th century, though subsequent leaders (including Constantine) aspired to and sometimes gained control of both regions. Theodosius I, who established Christianity as the official religion of the Roman Empire, died in 395 and was the last emperor to rule over a united Roman Empire; following his death, the division into western and eastern halves, each under its own emperor, became permanent. By the end of the 5th century, the Western Roman Empire had been overrun by the Germanic tribes, while the Eastern Roman Empire (known also as the Byzantine Empire) continued to thrive. Thus, the political unity of the Roman Empire was the first to fall.