Delphi
In 356 BC the Phocians under Philomelos captured and sacked Delphi, leading to the Third Sacred War (356–346 BC), which ended with the defeat of the former and the rise of Macedon under the reign of Philip II. This led to the Fourth Sacred War (339 BC), which culminated in the Battle of Chaeronea (338 BC) and the establishment of Macedonian rule over Greece.
In Delphi, Macedonian rule was superseded by the Aetolians in 279 BC, when a Gallic invasion was repelled, and by the Romans in 191 BC. The site was sacked by Lucius Cornelius Sulla in 86 BC, during the Mithridatic Wars, and by Nero in 66 AD. Although subsequent Roman emperors of the Flavian dynasty contributed towards to the restoration of the site, it gradually lost importance. In the course of the 3rd century mystery cults became more popular than the traditional Greek pantheon. Christianity, which started as yet one more mystery cult, soon gained ground, and this eventually resulted in the persecution of pagans in the late Roman Empire. The anti-pagan legislation of the Flavian dynasty deprived ancient sanctuaries of their assets. The emperor Julian attempted to reverse this religious climate, yet his "pagan revival" was particularly short-lived. When the doctor Oreibasius visited the oracle of Delphi, in order to question the fate of paganism,he received a pessimistic answer:
Frederick I, Holy Roman Emperor
In 1164 Frederick took what are believed to be the relics of the "Biblical Magi" (the Wise Men or Three Kings) from the Basilica di Sant'Eustorgio in Milan and gave them as a gift (or as loot) to the Archbishop of Cologne, Rainald of Dassel. The relics had great religious significance and could be counted upon to draw pilgrims from all over Christendom. Today they are kept in the Shrine of the Three Kings in the Cologne cathedral. After the death of the antipope Victor IV, Frederick supported antipope Paschal III, but he was soon driven from Rome, leading to the return of Pope Alexander III in 1165.
In the meantime Frederick was focused on restoring peace in the Rhineland, where he organized a magnificent celebration of the canonization of Charles the Great (Charlemagne) at Aachen, under the authority of the antipope Paschal III. Concerned over rumours that Alexander III was about to enter into an alliance with the Byzantine Emperor Manuel I, in October 1166 Frederick embarked on his fourth Italian campaign, hoping as well to secure the claim of Paschal III and the coronation of his wife Beatrice as Holy Roman Empress. This time, Henry the Lion refused to join Frederick on his Italian trip, tending instead to his own disputes with neighbors and his continuing expansion into Slavic territories in northeastern Germany. In 1167 Frederick began besieging Ancona, which had acknowledged the authority of Manuel I; at the same time, his forces achieved a great victory over the Romans at the Battle of Monte Porzio. Heartened by this victory, Frederick lifted the siege of Ancona and hurried to Rome, where he had his wife crowned empress and also received a second coronation from Paschal III. Unfortunately, his campaign was halted by the sudden outbreak of an epidemic (malaria or the plague), which threatened to destroy the Imperial army and drove the emperor as a fugitive to Germany, where he remained for the ensuing six years. During this period, Frederick decided conflicting claims to various bishoprics, asserted imperial authority over Bohemia, Poland, and Hungary, initiated friendly relations with Manuel I, and tried to come to a better understanding with Henry II of England and Louis VII of France. Many Swabian counts, including his cousin the young Duke of Swabia, Frederick IV, died in 1167, so he was able to organize a new mighty territory in the Duchy of Swabia under his reign in this time. Consequently, his younger son Frederick V became the new Duke of Swabia in 1167, while his eldest son Henry was crowned King of the Romans in 1169, alongside his father who also retained the title.