Medical ultrasound
A contrast medium for medical ultrasonography is a formulation of encapsulated gaseous microbubbles to increase echogenicity of blood, discovered by Dr Raymond Gramiak in 1968 and named contrast-enhanced ultrasound. This contrast medical imaging modality is clinically used throughout the world, in particular for echocardiography in the United States and for ultrasound radiology in Europe and Asia.
Bioinstrumentation
Biomedical engineering and bioinstrumentation are new terms, but the practice behind them has existed for many generations. Since the beginning of man kind, humans have used what was available to them to treat the medical mishaps they encountered. Biomedical engineering was most developed in the nineteenth century. In the recent years, biomedical engineering has gained popularity and focused on creating solutions for issues in human physiology. Since then, inventions such as X-rays and stethoscopes have progressed and revolutionized the medical field. 
Bioinstrumentation was first developed in earnest by NASA during their early space missions, to gain a better understanding of how humans were affected by space travel. These early bioinstrumentation sensor arrays built by NASA constantly monitored astronauts ECG, respiration, and body temperature; and later measured blood pressure. This allowed physicians to monitor the astronauts vital-signs for potential problems. Data taken from Apollo 15 ECG bioinstrumentation showed periods of cardiac arrhythmia, which physicians and planners used to alter expected workload, diet, and the drugs in the on-board medical kits.