Chameleon (comics)
Created by writer Stan Lee and artist Steve Ditko, the character first appeared in "The Amazing Spider-Man" #1 (March 1963), making him the first member of Spider-Man's rogues' gallery, based on issue publication date, excluding the burglar who murdered Ben Parker (Supercharger was the first Spider-Man supervillain chronologically). He is also well known to be related to Kraven the Hunter. That revealed relationship helped evolve him as a major villain compared to his original depiction of being just a solo villain in the original issue of "The Amazing Spider-Man".
Legacy hero
One of the best examples exists in Disney's "Gargoyles", as a multi-generational line of villains known as the Hunter, originates with the TV series' fictionalized depiction of the historic Gille Coemgáin of Moray as a boy. The young "Gillecomegain", as he is known within the series' storyline, is confronted by the evil female gargoyle Demona and slashed by her on his face, and the trio of slash wound scars on Gillecomegain's face, carried by him for the rest of his life as he seeks his revenge on the female gargoyle, becomes part of the "Hunter" disguise for succeeding examples of the Demona-hunting antagonists.