Delphi
In 356 BC the Phocians under Philomelos captured and sacked Delphi, leading to the Third Sacred War (356–346 BC), which ended with the defeat of the former and the rise of Macedon under the reign of Philip II. This led to the Fourth Sacred War (339 BC), which culminated in the Battle of Chaeronea (338 BC) and the establishment of Macedonian rule over Greece.
In Delphi, Macedonian rule was superseded by the Aetolians in 279 BC, when a Gallic invasion was repelled, and by the Romans in 191 BC. The site was sacked by Lucius Cornelius Sulla in 86 BC, during the Mithridatic Wars, and by Nero in 66 AD. Although subsequent Roman emperors of the Flavian dynasty contributed towards to the restoration of the site, it gradually lost importance. In the course of the 3rd century mystery cults became more popular than the traditional Greek pantheon. Christianity, which started as yet one more mystery cult, soon gained ground, and this eventually resulted in the persecution of pagans in the late Roman Empire. The anti-pagan legislation of the Flavian dynasty deprived ancient sanctuaries of their assets. The emperor Julian attempted to reverse this religious climate, yet his "pagan revival" was particularly short-lived. When the doctor Oreibasius visited the oracle of Delphi, in order to question the fate of paganism,he received a pessimistic answer:
Battle of Chaeronea (338 BC)
Philip was not originally a belligerent in the Sacred War, but became involved at the request of the Thessalians. Seeing an opportunity to expand his influence into Greece proper, Philip obliged, and in 353 or 352 BC won a decisive victory over the Phocians at the Battle of Crocus Field in Thessaly. In the aftermath, Philip was made "archon" of Thessaly, which gave him control of the levies and revenues of the Thessalian Confederation, thereby greatly increasing his power. However, Philip did not intervene further in the Sacred War until 346 BC. Early in that year, the Thebans, who had borne the brunt of the Sacred War, together with the Thessalians, asked Philip to assume the "leadership of Greece" and join them in fighting the Phocians. Philip's power was by now so great that ultimately the Phocians did not even attempt to resist, and instead surrendered to him; Philip was thus able to end a particularly bloody war without any further fighting. Philip allowed the Amphictyonic council the formal responsibility of punishing the Phocians, but ensured that the terms were not overly harsh; nevertheless, the Phocians were expelled from the Amphictyonic League, all their cities were destroyed, and they were resettled in villages of no more than fifty houses.