Chameleon (comics)
Created by writer Stan Lee and artist Steve Ditko, the character first appeared in "The Amazing Spider-Man" #1 (March 1963), making him the first member of Spider-Man's rogues' gallery, based on issue publication date, excluding the burglar who murdered Ben Parker (Supercharger was the first Spider-Man supervillain chronologically). He is also well known to be related to Kraven the Hunter. That revealed relationship helped evolve him as a major villain compared to his original depiction of being just a solo villain in the original issue of "The Amazing Spider-Man".
Chameleon (comics)
After Spider-Man was unmasked, the Chameleon gathered a gang of villains called the Exterminators, including Will O' The Wisp, Scarecrow, Swarm, and Electro and also blackmailed the Molten Man into his employ all in an effort to defeat Spider-Man and attack his family.