History of Haiti
Following the arrival of Europeans, La Hispaniola's indigenous population suffered greatly to near extinction, in possibly the worst case of depopulation in the Americas. A commonly accepted hypothesis attributes the high mortality of this colony in part to European diseases to which the natives had no immunity. A small number of Taínos were able to survive and set up villages elsewhere. Spanish interest in Hispaniola began to wane in the 1520s, as more lucrative gold and silver deposits were found in Mexico and South America. Thereafter, the population of Spanish Hispaniola grew at a slow pace.
El Salvador
By 1521, the indigenous population of the Mesoamerican area had been drastically reduced by the smallpox epidemic that was spreading throughout the territory, although it had not yet reached pandemic levels in Cuzcatlán. The first known visit by Spaniards to what is now Salvadoran territory was made by the Spanish admiral, Andrés Niño, who led a Spanish expedition to Central America. He disembarked in the Gulf of Fonseca on May 31, 1522, at Meanguera island, naming it Petronila, and then discovered Jiquilisco Bay on the mouth of Lempa River. The first indigenous people to have contact with the Spanish were the Lenca of eastern El Salvador.