Margherita Colonna
She was born in Palestrina about 1255. Her father, Oddone Colonna, died when she was about two years old. Her mother, who was also named Margherita and who was the sister of Matteo Rosso Orsini and a pious woman, died when Margherita was probably a little over ten years old. Margherita was left in the care of her older brothers.
Julia Pastrana
Julia Pastrana (1834 – 25 March 1860) was a performer and singer during the 19th century. Pastrana, an indigenous woman from Mexico, was born in 1834, somewhere in the state of Sinaloa. She was born with a genetic condition, hypertrichosis terminalis (or generalized hypertrichosis lanuginosa); her face and body were covered with straight black hair. Her ears and nose were unusually large, and her teeth were irregular. The latter condition was caused by a rare disease, undiagnosed in her lifetime, Gingival hyperplasia, which thickened her lips and gums.