History of the East–West Schism
Disunion in the Roman Empire further contributed to disunion in the Church. The Emperor Diocletian famously divided the administration of the eastern and western portions of the Empire in the early 4th century, though subsequent leaders (including Constantine) aspired to and sometimes gained control of both regions. Theodosius the Great, who established Nicene Christianity as the official religion of the Roman Empire (see Edict of Thessalonica), was the last Emperor to rule over a united Roman Empire. Following his death in 395, the division into western and eastern halves, each for a few decades still under its own Emperor, was never reunited.
Near East
It has pleased western historians to write of a decline of the Ottoman Empire as though a stable and uncontested polity of that name once existed. The borders did expand and contract but they were always dynamic and always in "question" right from the beginning. The Ottoman Empire was created from the lands of the former eastern Roman Empire on the occasion of the latter's violent demise. The last Roman emperor died fighting hand-to-hand in the streets of his capital, Constantinople, overwhelmed by the Ottoman military, in May, 1453. The victors inherited his remaining territory in the Balkans.