Chameleon (comics)
Created by writer Stan Lee and artist Steve Ditko, the character first appeared in "The Amazing Spider-Man" #1 (March 1963), making him the first member of Spider-Man's rogues' gallery, based on issue publication date, excluding the burglar who murdered Ben Parker (Supercharger was the first Spider-Man supervillain chronologically). He is also well known to be related to Kraven the Hunter. That revealed relationship helped evolve him as a major villain compared to his original depiction of being just a solo villain in the original issue of "The Amazing Spider-Man".
The Great Darkness Saga
Brainiac 5 is the only Legionnaire (other than Mon-El) with any knowledge of Darkseid or his homeworld, Apokolips. Once he briefs Dream Girl, she sends out a second general alarm to all of the Legion's super-powered allies, including Supergirl (who resides in the 20th century) and the Legion of Substitute Heroes. Throughout United Planets territory, the Kryptonian intelligence agent Dev-Em, the Heroes of Lallor, the Wanderers, the Substitute Heroes and the Legionnaires all struggle to hold back the onslaught of attacking Daxamites. On Takron-Galtos, a de-powered Chameleon Boy fends off an attack from a Daxamite child by using judo to toss him into a cell with Validus, the mysterious childlike creature who is the most powerful member of the Fatal Five.