Oxytocin
It has been shown that oxytocin differentially affects males and females. Females who are administered oxytocin are overall faster in responding to socially relevant stimuli than males who received oxytocin. Additionally, after the administration of oxytocin, females show increased amygdala activity in response to threatening scenes; however, males do not show increased amygdala activation. This phenomenon can be explained by looking at the role of gonadal hormones, specifically estrogen, which modulate the enhanced threat processing seen in females. Estrogen has been shown to stimulate the release of oxytocin from the hypothalamus and promote receptor binding in the amygdala.
Pillow talk
The content of pillow talk typically includes the sexual act itself, stories and confessions, expressions of affection and appreciation, and playful humor. A line of research done on pillow talk has revolved around the hormone known as oxytocin; this "bonding hormone" is related to other effects, such as decreasing stress, decreasing perceptions of social threat, increasing bonding, and increasing the ability to read emotional cues. This hormone has been known to increase in the body proceeding sexual activity between two people that have reached the point of orgasm. The individuals involved in this act of coitus can benefit from this process by opening up in a sense of communication and trust. A study done by Amanda Denes (2012), shows that partners who orgasm are more likely to engage in the act of pillow talk versus partners who do not orgasm.