Scrupulosity
Little evidence is available on the use of medications to treat scrupulosity. Although serotonergic medications are often used to treat OCD, studies of pharmacologic treatment of scrupulosity in particular have produced so few results that even tentative recommendations cannot be made.
Harris Isbell
the clinical use of opiate antagonists (e.g., nalorphine/Nalline and naloxone/Narcan) as treatment for opiate overdoses, 
the ability of methadone to alleviate opiate withdrawal symptoms,
rapid tolerance but lack of physical dependence with LSD,
cross-tolerance between LSD and psilocybin,
and the ability of pure THC to cause marijuana-like effects.
New pharmaceutical substances were assayed (in the prisoner population) for their abuse and addiction (substance dependence) potential (medications for pain, cough, and diarrhea were of particular concern), and this information was utilized by groups such as the World Health Organization.