Endometriosis
Surgery is more effective than medicinal intervention for addressing infertility associated with endometriosis. Surgery attempts to remove endometrial tissue and preserve the ovaries without damaging normal tissue. In-vitro fertilization (IVF) procedures are effective in improving fertility in many women with endometriosis.
Carlos Simon (gynaecologist)
Since 1991 he has contributed with his pioneering works to the research and clinical solution of the problems that produce infertility which is suffered by the 10% of the couples in reproductive age in the world. He has worked on the clinical demonstration and molecular mechanisms which control the deleterious effect of the high levels of oestradiol hormone changing the regular clinical practice and initiating the concept of “mild stimulation”. By employing the technique of microarrays he identified the transcriptomic sequences of the genes involved in the human endometrial receptivity, by publishing his discoveries in 20 papers as the first or last author, the former is the most quoted in the scientific journal Molecular Human Reproduction. The clinical translation of his results has led in a patent about the creation of a customized array named endometrial receptivity array (ERA) for the molecular diagnosis of the endometrial receptivity in infertile patients (Díaz-Gimeno P, et al. Fertil Steril. 2011). All the same, he has created a data base bank with free access about the endometrial receptivity managed by the University of Valencia. Finally thanks to the funding of an excellence project PROMETEO to research the origin of the endometrial stem cells in human, he has been the first scientific in discovering that the endometrial stem cells isolated are able to reconstruct the human endometrium.