Chameleon (comics)
Created by writer Stan Lee and artist Steve Ditko, the character first appeared in "The Amazing Spider-Man" #1 (March 1963), making him the first member of Spider-Man's rogues' gallery, based on issue publication date, excluding the burglar who murdered Ben Parker (Supercharger was the first Spider-Man supervillain chronologically). He is also well known to be related to Kraven the Hunter. That revealed relationship helped evolve him as a major villain compared to his original depiction of being just a solo villain in the original issue of "The Amazing Spider-Man".
Legion of Super-Heroes
Initial issues of this series reintroduced the characters, and provided new and divergent origins for them. Most characters resemble their previous counterparts in costume and powers, with the most notable exceptions including Chameleon Boy, now called simply Chameleon and depicted as an androgynous creature; Star Boy, who in this version of the Legion is black; Colossal Boy, who is now a giant who shrinks to human size; and Phantom Girl, who exists in two universes at once and has conversations with people in her own dimension while talking to Legionnaires at the same time.