U.S. Route 101
The nearly highway's northern terminus is in Tumwater, Washington: the route remains along the Olympic Peninsula's coastal perimeter west, north, and east; the northernmost point on the highway is in Port Angeles. The southern terminus of US 101 is in Los Angeles at the East Los Angeles Interchange, the world's busiest freeway interchange.
Ontario Highway 101
Approaching Chapleau, Highway 101 encounters Highway 129, onto which it turns northward and becomes concurrent for . Prior to entering the town, Highway 101 branches eastward, passing north of Chapleau Airport and resuming its course through the wilderness. Midway between Chapleau and Timmins, the route passes the village of Foleyet. It briefly travels through Timiskaming District before entering Cochrane District, through which the remainder of the route passes. After entering the city of Timmins, and approximately east of Highway 129, the route meets Highway 144, which travels south to Sudbury. Although classified as a city, very little of Timmins is developed, with the urban portion located in the centre of the city. Through the urban portion, Highway 101 is not maintained as a provincial highway and is a local road. This discontinuity begins just east of Kamiskotia Road and continues for to Gervais Street North.
East of Gervais Street North, Highway 101 travels northeast to Hoyle, passing beside several large open pit mines on the outskirts of Timmins. It then turn east and crosses the Frederick House River on the northern shores of Night Hawk Lake. The route passes through the only agricultural area along its journey, travelling straight for the remainder of the distance to Highway 11 west of Matheson. After a concurrency with Highway 11, Highway 101 branches north into Matheson, where it crosses the Abitibi River before curving east. Returning to wilderness, the route zig-zags towards the Ontario–Quebec border near Rouyn-Noranda, travelling several kilometres south of Lake Abitibi. The roadway continues eastward as Quebec Route 388 into the Abitibi-Témiscamingue region. With the exception of an undivided urban four lane section through Timmins, from Government Road in Mountjoy to Gervais Road South in Porcupine, the entire highway is two lanes wide.