Orientia tsutsugamushi
"O. tsutsugamushi" causes a complex and dangerous infection scrub typhus. Infection starts when chiggers bite on the skin during their feeding. The bacteria are deposited at the site of feeding (inoculation), where they multiply. They cause progressive tissue damage (necrosis). Necrosis progresses to inflammation of the blood vessels called vasculitis. This in turn causes inflammation of the lymph nodes, called lymphadenopathy. Within a few days, vasculitis extends to various organs including liver, brain, kidney, meninges and the lung. The disease is responsible for nearly a quarter of all the febrile (high fever) illness in endemic areas. Mortality in severe case or due to improper treatment or misdiagnosis may be as high as 30-70%. About 6% of infected people die untreated, and 1.4% of the patients die even with medical treatment. Moreover, death rate can be as high as 13% where medical treatment is not properly handled. In cases of misdiagnosis and failure of treatment, systemic complications rapidly develop including acute respiratory distress syndrome, acute kidney failure, encephalitis, gastrointestinal bleeding, hepatitis, meningitis, myocarditis, pancreatitis, pneumonia, septic shock, sub-acute thyroiditis, and multi-organ dysfunctions. Harmful symptoms involving multiple organ failure and neurological impairment are difficult to treat, and can be lifelong debilitation or directly fatal. The central nervous system is often affected and result in various complications including cerebellitis, cranial nerve palsies, meningoencephalitis, plexopathy, transverse myelitis, neuroleptic malignant syndrome, and Guillan-Barré syndrome. Death rates due to complications can be up to 14% in brain infections, and 24% with multiple organ failure. It is the major cause of acute encephalitis syndrome in India, where viral infection Japanese encephalitis has been regarded as the main factor.
Erythrina
In Hinduism, the "mandara" tree in Indra's garden in Svarga is held to be "E. stricta". The same motif is found in Tibetan Buddhism, where the "man da ra ba" growing in Sukhavati is identified as an Indian coral tree ("E. variegata"). The concept of the Five Trees of Paradise is also found in Christian Gnosticism. Though as none of the trees is identified as an "Erythrina" here, the concept might not be as directly related to the Asian religions as some presume.
The seeds of at least one-third of the species contain potent erythrina alkaloids, and some of these are used for medicinal and other purposes by indigenous peoples. They are all toxic to some degree, however, and the seeds of some can cause fatal poisoning. The chemical compounds found in plants in this genus include alkaloids such as scoulerine, erysodin, erysovin (namely in "E. flabelliformis"), and the putative anxiolytic erythravine (isolated from Mulungu, "E. mulungu").
Root tubers of "Erythrina" species have been traditional food for aborigines of the Northern Territory of Australia.Horticultural hybrids:Growing, selling or possessing "Erythrina" spp. except for ornamental purposes, is prohibited by Louisiana State Act 159 (where the genus is misspelled "Erythina"); the Act covers various known, suspected, or rumored hallucinogenic plants.