Chameleon (comics)
Created by writer Stan Lee and artist Steve Ditko, the character first appeared in "The Amazing Spider-Man" #1 (March 1963), making him the first member of Spider-Man's rogues' gallery, based on issue publication date, excluding the burglar who murdered Ben Parker (Supercharger was the first Spider-Man supervillain chronologically). He is also well known to be related to Kraven the Hunter. That revealed relationship helped evolve him as a major villain compared to his original depiction of being just a solo villain in the original issue of "The Amazing Spider-Man".
Pantheon (Marvel Comics)
Agamemnon, a half-human and half-Asgardian god, is born immortal. Although he never physically ages beyond the age of 16, the Pantheon are all his descendants. Stationed in the Mount, their headquarters in a Nevada desert, the Pantheon recruits the Hulk as a member and ally after he is transformed into the Merged Hulk persona. The Hulk accepts the offer as a means of making up for the damage he's done in his Savage Hulk days. The Hulk works with the Pantheon on many rescue and relief missions, the focus of the Pantheon's purpose. In return, several members help the Hulk out with personal missions, which sometimes dovetail into the Pantheon's intended purposes.