Orientia tsutsugamushi
"O. tsutsugamushi" causes a complex and dangerous infection scrub typhus. Infection starts when chiggers bite on the skin during their feeding. The bacteria are deposited at the site of feeding (inoculation), where they multiply. They cause progressive tissue damage (necrosis). Necrosis progresses to inflammation of the blood vessels called vasculitis. This in turn causes inflammation of the lymph nodes, called lymphadenopathy. Within a few days, vasculitis extends to various organs including liver, brain, kidney, meninges and the lung. The disease is responsible for nearly a quarter of all the febrile (high fever) illness in endemic areas. Mortality in severe case or due to improper treatment or misdiagnosis may be as high as 30-70%. About 6% of infected people die untreated, and 1.4% of the patients die even with medical treatment. Moreover, death rate can be as high as 13% where medical treatment is not properly handled. In cases of misdiagnosis and failure of treatment, systemic complications rapidly develop including acute respiratory distress syndrome, acute kidney failure, encephalitis, gastrointestinal bleeding, hepatitis, meningitis, myocarditis, pancreatitis, pneumonia, septic shock, sub-acute thyroiditis, and multi-organ dysfunctions. Harmful symptoms involving multiple organ failure and neurological impairment are difficult to treat, and can be lifelong debilitation or directly fatal. The central nervous system is often affected and result in various complications including cerebellitis, cranial nerve palsies, meningoencephalitis, plexopathy, transverse myelitis, neuroleptic malignant syndrome, and Guillan-Barré syndrome. Death rates due to complications can be up to 14% in brain infections, and 24% with multiple organ failure. It is the major cause of acute encephalitis syndrome in India, where viral infection Japanese encephalitis has been regarded as the main factor.
Blade of the Immortal (film)
Fifty-two years later, now an ageless immortal, Manji is approached by Rin Asano who requests his aid as a bodyguard to help avenge the death of her father, Kurose, at the hands of Kagehisa Anotsu and the Ittō-ryū. While Manji initially refuses, he reconsiders when Rin is attacked by the Ittō-ryū member Sabato Kuroi who had the severed head of Rin's mother mounted on his left shoulder. Word of Sabato's death reaches Kagehisa after setting up the Ittō-ryū's contract with Kagimura Habaki for a place in the shogunate, sending Taito Magatsu to deal with Rin and her bodyguard. Magatsu is defeated, but is spared as he reveals Manji's immortality to the other Ittō-ryū members. Manji later encounters the Ittō-ryū member Eiku Shizuma, who reveals to have also had bloodworms placed in his body by Yaobikuni while nearly killing Manji with a rare poison that disrupts the bloodworms. However, after 200 years of immortality, he is tired of being alive, so he lets Manji kill him with a poisoned sword without fighting back.