Chameleon (comics)
The Chameleon (Dmitri Smerdyakov) is a fictional character, a supervillain appearing in American comic books published by Marvel Comics. Commonly depicted as a master of disguise and the half-brother of Kraven the Hunter, the Chameleon is known as being the first supervillain for Spider-Man to face by first appearing in the original issue of "The Amazing Spider-Man".
Chameleon (comics)
However, the Chameleon was dealt a most humiliating defeat at the hands of Aunt May, when he attempted to trick her into believing he was Peter, then murder her. However, May was not fooled by any means, and defeated the villain with a plate of oatmeal-raisin cookies laced with Ambien. The Rhino was also employed as part of the team up and later defeated Spider-Man only to be unable to collect payment from Chameleon as he was already captured.