Missouri
Located in Tornado Alley, Missouri also receives extreme weather in the form of severe thunderstorms and tornadoes. The most recent tornado in the state to cause damage and casualties was the 2011 Joplin tornado, which destroyed roughly one-third of the city of Joplin. The tornado caused an estimated $1–3 billion in damages, killed 159 (+1 non-tornadic), and injured over 1,000 people. It was the first EF5 to hit the state since 1957 and the deadliest in the U.S. since 1947, making it the seventh deadliest tornado in American history and 27th deadliest in the world. St. Louis and its suburbs also have a history of experiencing particularly severe tornadoes, the most recent memorable one being an EF4 tornado that damaged Lambert-St. Louis International Airport on April 22, 2011. One of the worst tornadoes in American history struck St. Louis on May 27, 1896, killing at least 255 and causing $10 mil. damage ($3.9 bil. damage in 2009) or $ in today's dollars.
1936 Tupelo–Gainesville tornado outbreak
Around 8:30 p.m., April 5, 1936, the Tupelo tornado, the fourth-deadliest tornado in United States history, emerged from a complex of storm cells and touched down in a rural area approximately eight miles outside of the city. Making its way toward Tupelo, the massive tornado killed a family of 13 as their house was swept away, and injured many more before reaching Tupelo's west side. Retroactively rated F5 on the modern Fujita scale, it caused total destruction along its path through the Willis Heights neighborhood. Dozens of large and well built mansions were swept completely away in this area. Although missing the business district, the tornado moved through the residential areas of north Tupelo, destroying many homes, and killing whole families. The Gum Pond area of Tupelo was the worst hit. Homes along the pond were swept into the water with their victims. The majority of the bodies were found in Gum Pond, the area which is now Gumtree Park. Reportedly, many bodies were never recovered from the pond. Reports were that the winds were so strong, pine needles were embedded into trunks of trees. As the tornado exited the city's east side, the large concrete Battle of Tupelo monument was toppled to the ground and destroyed. Two nearby brick gate posts were broken off at the base and blown over as well. East of town, granulated structural debris from the city was strewn and wind-rowed for miles through open fields. 
According to records, the Tupelo tornado leveled 48 city blocks and at least 200—perhaps up to 900—homes, killing at least 216 people and injuring at least 700 people. The tornado destroyed the water tower and produced numerous fires in its wake, though overnight rains which left knee-deep water in some streets contained the flames. Though 216 remained the final death toll, 100 persons were still hospitalized at the time it was set. Subsequently, the Mississippi State Geologist estimated a final, unofficial death toll of 233. Some estimates indicate that the actual total may have reached 250 or more dead; few of the devastated Black neighborhoods were thoroughly surveyed and their dead remained uncounted. Because newspapers published only the names of injured whites—a stark corollary of racial discrimination that even separated Black and white relief programs after the tornado—it was difficult to follow up on the fates of injured Blacks. Similar forms of discrimination persisted into the 1940s and 1950s, affecting documentation of tornado deaths even then. Notably, among the survivors were one-year-old Elvis Presley and his mother, Gladys. His father, Vernon, was out of town looking for work at that time.