Compulsive hoarding
Obsessive-compulsive disorders are treated with various serotonergic antidepressants including the tricyclic antidepressant clomipramine and various SSRI medications. With existing drug therapy, OCD symptoms can be controlled, but not cured. Several of these compounds (including paroxetine, which has an FDA indication) have been tested successfully in conjunction with OCD hoarding.
Marble burying
Critics also point out that the marble burying test reacts to two types of drugs the SSRIs and benzodiazepines. Benzodiazepines have been shown to have no effect on patients suffering from OCD. If the test measured OCD then benzodiazepines would not affect rodent behavior.