Arachne
It has also been suggested that Jeremias Gotthelf's nineteenth century novella, "The Black Spider", was heavily influenced by the Arachne story from Ovid's "Metamorphoses". In the novella, a woman is turned into a venomous spider having reneged on a deal with the devil.
Tarantula (Marvel Comics)
Tarantula is hired by the Brand Corporation to silence an informer, but is thwarted by Spider-Man. The Brand Corporation then orders him to kill Spider-Man. In an attempt to bestow him with spider-powers, he is injected with a mutagenic serum and placed in an electrolyte bath. Will o' The Wisp disrupts the mutagenic process, causing Tarantula to start transforming into a gigantic, monstrous spider-like being. He falls into Jamaica Bay, but survives the plunge and continues to mutate, and then battles Spider-Man atop a tall New York City building. Horrified and disgusted with what he has become, he leaps off the building, begging for the police officers gathered below to kill him. In a hail of gunfire, Rodriquez strikes the street below and dies.