U.S. Route 101
The nearly highway's northern terminus is in Tumwater, Washington: the route remains along the Olympic Peninsula's coastal perimeter west, north, and east; the northernmost point on the highway is in Port Angeles. The southern terminus of US 101 is in Los Angeles at the East Los Angeles Interchange, the world's busiest freeway interchange.
Ohio State Route 101
Near the southern city limits of Sandusky, SR 101 formerly traveled on a straight line along Tiffin Avenue where it began a concurrency with US 6 at Venice Road and Sanford Street. Because of long-time concerns about a grade crossing with the Norfolk Southern railroad at Tiffin Street and nearby Venice Street (which carried US 6 at the time). The project to realign the two highways began in 2010 and was completed four years later. , the former alignment of SR 101 is designated SR 101-J (with former alignments of Venice Road being designated US 6-C and US 6-J); the "J" suffix meant that the route is awaiting abandonment by the Ohio Department of Transportation.