Arachne
It has also been suggested that Jeremias Gotthelf's nineteenth century novella, "The Black Spider", was heavily influenced by the Arachne story from Ovid's "Metamorphoses". In the novella, a woman is turned into a venomous spider having reneged on a deal with the devil.
Spider-Woman (Gwen Stacy)
In the alternate reality designated Earth-65, Gwen Stacy from Midtown High School is bitten by the radioactive spider and becomes a superhero going by the name of Spider-Woman. As Gwen Stacy, she is depicted as a drummer alongside her friends Mary Jane Watson, Betty Brant and Glory Grant, simply called the Mary Janes. Shortly after she begins fighting crime, one of her classmates, Peter Parker, attempts to exact revenge on those who bullied him in Midtown High School, becoming Earth-65's version of the Lizard. Gwen subdues him, but Peter dies towards the end of the battle due to the chemical he used. Spider-Woman is blamed for his death, causing an outcry for her arrest, led by J. Jonah Jameson. Her father, George Stacy, a NYPD police chief, begins a hunt for her along with Captain Frank Castle and Detective Jean DeWolff. While the Mary Janes are attempting to perform in a concert, an assassin is sent after Gwen Stacy's father, who is in the audience. As Spider-Woman, she successfully defeats the assassin. During the battle, Captain Stacy holds Spider-Woman at gun point, with Gwen Stacy taking off her mask to reveal who she is to her father. Shocked upon learning Spider-Woman's identity, he tells her to run before he changes his mind.