U.S. Route 101
The nearly highway's northern terminus is in Tumwater, Washington: the route remains along the Olympic Peninsula's coastal perimeter west, north, and east; the northernmost point on the highway is in Port Angeles. The southern terminus of US 101 is in Los Angeles at the East Los Angeles Interchange, the world's busiest freeway interchange.
Missouri Route 101
Route 101 starts at the Missouri–Arkansas state line, at the northern terminus of Arkansas Route 101 and County Road 583 (CRD 583). The road travels through a forest and parallel to the state line for the first . At CRD 588, the route turns northeastward, intersecting a few driveways until it reaches CRD 586, where it turns northward past the intersection. Route 101 travels eastward before it intersects CRD 584, and enters the corporate limits of Bakersfield at CRD 585. The route briefly travels north and intersects Route O, which leads to the unincorporated area of Udall. The road enters the center of the city at Main Street and curves northward at the western terminus of Route 142. Route 101 leaves the city north of Starks. The road enters through a mix of farmland and forests as it continued through southeast Ozark County. At CRD 101-174, the route begins to turn northeastward and later intersects CRD 597. Route 101 crosses the county line at CRD 7890, and enters Howell County. Once inside the county, the route turns north at Route YY and intersects CRD 7690. The road turns to the northeast in the community of Caulfield, and ends at US 61 in a T-intersection.