Oxytocin
It has been shown that oxytocin differentially affects males and females. Females who are administered oxytocin are overall faster in responding to socially relevant stimuli than males who received oxytocin. Additionally, after the administration of oxytocin, females show increased amygdala activity in response to threatening scenes; however, males do not show increased amygdala activation. This phenomenon can be explained by looking at the role of gonadal hormones, specifically estrogen, which modulate the enhanced threat processing seen in females. Estrogen has been shown to stimulate the release of oxytocin from the hypothalamus and promote receptor binding in the amygdala.
Oxytocin (medication)
One IU of oxytocin is the equivalent of about 2 μg or mcg of pure peptide.Its uterine-contracting properties were discovered by British pharmacologist Sir Henry Hallett Dale in 1906. And its milk ejection property was described by Ott and Scott in 1910 and by Schafer and Mackenzie in 1911.