Christianity in Turkey
Constantinople became established in the ecclesiastical hierarchy at the Council of Constantinople in 381. Second only to Rome, the legendary origins of the Patriarchate of Constantinople go back to St. Andrew, Metrophanes and Alexander of Constantinople. Constantinople's primacy over the Patriarchates of Alexandria and Antioch was reaffirmed at the Council of Chalcedon in 481, after which the papacy in Rome supported Constantinople in its dispute with Alexandria over monophysitism. Later, when Rome sought to assert its primacy over Byzantium, the Eastern Orthodox church developed the doctrine of pentarchy as a response.
Europe
In the east a resurgent Byzantine Empire recaptured Crete and Cyprus from the Muslims and reconquered the Balkans. Constantinople was the largest and wealthiest city in Europe from the 9th to the 12th centuries, with a population of approximately 400,000. The Empire was weakened following the defeat at Manzikert and was weakened considerably by the sack of Constantinople in 1204, during the Fourth Crusade. Although it would recover Constantinople in 1261, Byzantium fell in 1453 when Constantinople was taken by the Ottoman Empire.