U.S. Route 101
The nearly highway's northern terminus is in Tumwater, Washington: the route remains along the Olympic Peninsula's coastal perimeter west, north, and east; the northernmost point on the highway is in Port Angeles. The southern terminus of US 101 is in Los Angeles at the East Los Angeles Interchange, the world's busiest freeway interchange.
Indiana State Road 101
The second portion of SR 101 is long and is within Ripley County. This sections of SR 101 begins at U.S. Route 50 (US 50) and heads north towards Milan. The road passes through rural farmland with a few houses as a two-lane highway. The road turns towards the northeast just south of SR 48. After SR 48 the highway turns back due north. This section ends at an interchange with Interstate 74 (I–74) in Penntown.