Ganciclovir
Ganciclovir has also been used with some success in treating "Human herpesvirus 6" infections.
Oncolytic virus
The first oncolytic virus approved by a national regulatory agency is genetically not modified ECHO-7 strain enterovirus RIGVIR, approved in Latvia in 2004 for treatment of skin melanoma. Later (in 2015 and 2016 respectively) it was also approved in Georgia and Armenia. In 2005 Chinese company, Shanghai Sunway Biotech registered an oncolytic adenovirus, a genetically modified adenovirus named H101. It gained regulatory approval in 2005 from the CFDA, for the treatment of head and neck cancer. The drug talimogene laherparepvec (OncoVex, T-VEC) was the first oncolytic herpes virus (a modified herpes simplex virus), approved for use by the US FDA and by the EMA in the EU in 2015 for the treatment of advanced inoperable melanoma. In a combined decision, members of the FDA's Oncology Drug Advisory Committee and Cellular, Tissue and Gene Therapies Advisory Committee voted 22-1 to recommend approval of the oncolytic immunotherapy.