KHII-TV
On March 7, 2006, Raycom Media announced that KFVE would affiliate with MyNetworkTV as part of a group deal involving many of Raycom-owned affiliates of The WB and UPN (whose consolidation and shutdowns the following September resulted in the creation of The CW Television Network, which would affiliate in Hawaii with a digital subchannel of KHON-TV). KFVE officially joined MyNetworkTV on September 5, 2006 and did not air The WB's final two weeks of prime-time programming (though it continued to air WB daytime and Saturday morning programming until the end of the network's existence).
KTXH
On January 24, 2006, the Warner Bros. unit of Time Warner and CBS Corporation announced that the two companies would shut down The WB and UPN and combine the networks' respective programming to create a new "fifth" network called The CW. Through an affiliation agreement with Tribune Broadcasting, KHWB (channel 39, which changed its callsign to KHCW shortly before the network's launch) was announced as The CW's Houston affiliate. Almost immediately, KTXH dropped all UPN network branding from its station promotions, revamped its logo to just feature the boxed "20", and ceased all promotion of any UPN programming. Additionally, the station began referring to itself in promos as "Houston's 20". Similar changes were also made to Fox's other UPN affiliates, as the initial list of CW charter affiliates consisted of both stations owned by the Tribune Company and network co-parent CBS. News Corporation also chose not to affiliate stations with The CW in markets where neither Tribune nor CBS (excluding CBS owned-and-operated stations) owned a station.
On February 22, 2006, in response to The CW's launch announcement, News Corporation announced the creation of a new "sixth" network called MyNetworkTV, which would be operated by Fox Television Stations and its syndication division Twentieth Television, with KTXH and the other Fox-owned UPN affiliates serving as charter affiliates. With the impending switch to MyNetworkTV, channel 20's on-air branding was changed to "My20" in June 2006. KTXH became a MyNetworkTV owned-and-operated station when the network began operations on September 5 of that year. Although UPN continued to broadcast its programming on stations across the United States until September 15, 2006 (with some stations airing the final two weeks of the network's programming outside their regular primetime slots), KTXH and its Fox-owned sister stations did not carry UPN's final two weeks of programming as those stations dropped the network entirely on August 31, 2006.