Orientia tsutsugamushi
"O. tsutsugamushi" causes a complex and dangerous infection scrub typhus. Infection starts when chiggers bite on the skin during their feeding. The bacteria are deposited at the site of feeding (inoculation), where they multiply. They cause progressive tissue damage (necrosis). Necrosis progresses to inflammation of the blood vessels called vasculitis. This in turn causes inflammation of the lymph nodes, called lymphadenopathy. Within a few days, vasculitis extends to various organs including liver, brain, kidney, meninges and the lung. The disease is responsible for nearly a quarter of all the febrile (high fever) illness in endemic areas. Mortality in severe case or due to improper treatment or misdiagnosis may be as high as 30-70%. About 6% of infected people die untreated, and 1.4% of the patients die even with medical treatment. Moreover, death rate can be as high as 13% where medical treatment is not properly handled. In cases of misdiagnosis and failure of treatment, systemic complications rapidly develop including acute respiratory distress syndrome, acute kidney failure, encephalitis, gastrointestinal bleeding, hepatitis, meningitis, myocarditis, pancreatitis, pneumonia, septic shock, sub-acute thyroiditis, and multi-organ dysfunctions. Harmful symptoms involving multiple organ failure and neurological impairment are difficult to treat, and can be lifelong debilitation or directly fatal. The central nervous system is often affected and result in various complications including cerebellitis, cranial nerve palsies, meningoencephalitis, plexopathy, transverse myelitis, neuroleptic malignant syndrome, and Guillan-Barré syndrome. Death rates due to complications can be up to 14% in brain infections, and 24% with multiple organ failure. It is the major cause of acute encephalitis syndrome in India, where viral infection Japanese encephalitis has been regarded as the main factor.
Hellblade: Senua's Sacrifice
In addition, "Hellblade" features fights against malformed representations of Northmen who block her progression, including occasional bosses. During those fights, Senua has her sword drawn out, and is turned towards one of her enemies, on which the camera is automatically focused; she can use two kind of attacks, quick or heavy, kick an enemy to prevent it from blocking her attacks, parry, or dodge. She can also charge the opponent she is currently focusing on, to either get closer or directly attack or kick it. If she parries or dodges enough, she can use her focus ability in battle to move faster than her enemies or dissipate the shadows some of them are made of, which makes them impervious to regular attacks. Once she obtains Gramr, Senua can charge her heavy attacks for additional damage and parries more efficiently, both of which can allow her to use her focus ability. If Senua suffers a strong hit, or several hits in a row, she falls to the ground, and the player must press the corresponding button repeatedly as fast as possible before an enemy deals her a fatal blow; if she does not get back up in time, she dies. The closer she is to death, the harder it is for her to get back up; she can also die from a regular hit, if she was already very close to death.