Chameleon (comics)
Created by writer Stan Lee and artist Steve Ditko, the character first appeared in "The Amazing Spider-Man" #1 (March 1963), making him the first member of Spider-Man's rogues' gallery, based on issue publication date, excluding the burglar who murdered Ben Parker (Supercharger was the first Spider-Man supervillain chronologically). He is also well known to be related to Kraven the Hunter. That revealed relationship helped evolve him as a major villain compared to his original depiction of being just a solo villain in the original issue of "The Amazing Spider-Man".
Ends of the Earth (Marvel Comics)
In a flashback, the Sinister Six are shown stealing objects from around the world to further their plans. In the present at Palazzo Senatorio, an international meeting of the world's greatest minds and the world leaders is held to discuss Doctor Octopus' offer. The Avengers and Spider-Man try to convince the leaders they cannot negotiate with a supervillain. When Al Gore says that Doctor Octopus would save them, Spider-Man punches him, revealing to everyone that Gore is the Chameleon in disguise. Spider-Man explains his new costume can detect which person is actually Chameleon. Meanwhile, at Horizon Labs, Mayor J. Jonah Jameson gives orders to shut down the laboratories, saying he doesn't care about the rest of the world. Back in Rome, a transmission from Doctor Octopus states he has activated the Octavian Lens which are blocking the harmful UV rays from the sun in order to reinforce his offer. Spider-Man is forced to let Chameleon go, but secretly places a Spider-Tracer on him. They follow Chameleon to the Mediterranean Coast where the rest of the Sinister Six is waiting. Although Thor is able to hurl Electro into the upper atmosphere, the Sinister Six successfully subdue the Avengers using the objects stolen in the flashback. Doctor Octopus says he has succeeded in another goal, defeating Spider-Man.