<s>[INST] What are some up and coming and high quality youtube channels in science and technology that I have probably not heard of? Note that I am subscribed to close to 1000 channels. [/INST] Here are some great options that you may not have heard of yet: 
Science Max which explores interesting scientific concepts with 3D animations and experiments.
Engineering With Nathan which provides educational content about engineering and technology.
Science Source News which provides a unique and informative look at the world of science through interviews and videos.
Science of Everything which provides an in-depth look at a variety of topics in science and technology.</s>\ <s>[INST] Can you give me some that focus on easy to understand topics? [/INST] Here are a few good YouTube channels that cover a variety of topics while still maintaining a high level of accessibility:

Mental Outlaw - A channel that explores a wide range of topics, from tech to science to pop culture. The videos are generally easy to follow and understand, and they cover a wide range of topics.

Leather Apron Club - A channel that asks big questions and provides thought-provoking answers. The concepts discussed on the channel are often complex, but they're always approached in a way that makes them understandable and interesting.

Luke Smith - A channel that delves into the world of technology, but also philosophy and religion</s>