<s>[INST] What effect does turning on the Yamanka factors have in human cells? [/INST] Turning on Yamanaka factors in human cells has the effect of inducing cellular reprogramming, converting the cells into a pluripotent state similar to that of embryonic stem cells. This can potentially have applications in regenerative medicine, disease modeling, and drug discovery.</s>\ <s>[INST] How where the Yamanaka factors discovered? [/INST] 