Dr. <a href="https://en.wikipedia.org/wiki/Ephraim_McDowell" id="mw5A" rel="mw:WikiLink" title="Ephraim McDowell">Ephraim McDowell</a> performs the first <a class="mw-redirect" href="https://en.wikipedia.org/wiki/Ovariotomy" id="mw5Q" rel="mw:WikiLink" title="Ovariotomy">ovariotomy</a>, removing a 22-pound <a href="https://en.wikipedia.org/wiki/Neoplasm" id="mw5g" rel="mw:WikiLink" title="Neoplasm">tumor</a>.<sup about="#mwt125" class="mw-ref reference" data-mw='{"name":"ref","attrs":{"name":"PMID30670290"},"body":{"id":"mw-reference-text-cite_note-PMID30670290-23"}}' id="cite_ref-PMID30670290_23-0" rel="dc:references" typeof="mw:Extension/ref"><a href="./December_25#cite_note-PMID30670290-23" id="mw5w" style="counter-reset: mw-Ref 23;"><span class="mw-reflink-text" id="mw6A">[23]</span></a></sup>