Seminole Wars: The <a class="mw-redirect" href="https://en.wikipedia.org/wiki/Battle_of_Negro_Fort" id="mwfQ" rel="mw:WikiLink" title="Battle of Negro Fort">Battle of Negro Fort</a> ends when a hot shot cannonball fired by US Navy Gunboat No. 154 explodes the fort's Powder Magazine, killing approximately 275. It is considered the deadliest single cannon shot in US history.