<a href="https://en.wikipedia.org/wiki/John_C._Calhoun" id="mwSw" rel="mw:WikiLink" title="John C. Calhoun">John C. Calhoun</a> becomes the first <a href="https://en.wikipedia.org/wiki/Vice_President_of_the_United_States" id="mwTA" rel="mw:WikiLink" title="Vice President of the United States">Vice President of the United States</a> to resign. He resigned after being elected Senator from South Carolina.