A <a href="https://en.wikipedia.org/wiki/1766_Istanbul_earthquake" id="mwcw" rel="mw:WikiLink" title="1766 Istanbul earthquake">large earthquake</a> causes heavy damage and loss of life in <a href="https://en.wikipedia.org/wiki/Istanbul" id="mwdA" rel="mw:WikiLink" title="Istanbul">Istanbul</a> and the Marmara region.<sup about="#mwt46" class="mw-ref reference" data-mw='{"name":"ref","attrs":{"name":"Ambraseys2000"},"body":{"id":"mw-reference-text-cite_note-Ambraseys2000-6"}}' id="cite_ref-Ambraseys2000_6-0" rel="dc:references" typeof="mw:Extension/ref"><a href="./May_22#cite_note-Ambraseys2000-6" id="mwdQ" style="counter-reset: mw-Ref 6;"><span class="mw-reflink-text" id="mwdg">[6]</span></a></sup>