The MARIO project deals with the problem of 3D registration o f Computed Tomog- raphy (CT) images (at two different instants of the breathin g cycle) and Positon Emission To- mography (PET) images of thoracic regions. In order to guara ntee physiologically plausible deformations, we present a novel method to incorporate a bre athing model in a non-linear registration procedure. Our registration method is based o the segmentation of anatomical structures and potential tumors, and on an automatic select ion of landmark points based on the curvature of the lung surface. The rigidity of the tumors is p reserved during the registration and constraints on the heart are included, while guaranteei ng a continuous deformation. Re- sults on one normal case and four pathological cases demonst rate the interest of this method to
['Sylvie Chambon', 'Antonio Moreno-Ingelmo', 'Anand P. Santhanam', 'Jannick P. Rolland', 'Isabelle Bloch']
MARIO : modélisation de l’anatomie normale et pathologique pour le recalage non linéaire entre images TDM et TEP en oncologie