Background#R##N#Transmembrane (TM) proteins are proteins that span a biological membrane one or more times. As their 3-D structures are hard to determine, experiments focus on identifying their topology (i. e. which parts of the amino acid sequence are buried in the membrane and which are located on either side of the membrane), but only a few topologies are known. Consequently, various computational TM topology predictors have been developed, but their accuracies are far from perfect. The prediction quality can be improved by applying a consensus approach, which combines results of several predictors to yield a more reliable result.
['Martin Klammer', 'David N. Messina', 'Thomas Schmitt', 'Erik L. L. Sonnhammer']
MetaTM - a consensus method for transmembrane protein topology prediction