Environmental shotgun sequencing (ESS) has potential to give greater insight into microbial communities than targeted sequencing of 16S regions, but requires much higher sequence coverage. The advent of next-generation sequencing has made it feasible for the Human Microbiome Project and other initiatives to generate ESS data on a large scale, but computationally efficient methods for analysing such data sets are needed.
['Christina Ander', 'Ole Schulz-Trieglaff', 'Jens Stoye', 'Anthony J. Cox']
metaBEETL: high-throughput analysis of heterogeneous microbial populations from shotgun DNA sequences