1 Summary We propose a method for visualizing a set of related metabolic pathways across organisms using 21/2 dimensional graph visualization. Interdependent, twodimensional layouts of each pathway are stacked on top of each other so that biologists get a full picture of subtle and significant dierences among the pathways. The (dis)similarities between pathways are expressed by the Hamming distances of the underlying graphs which are used to compute a stacking order for the pathways. Layouts are determined by a global layout of the union of all pathway graphs using a variant of the proven Sugiyama approach for layered graph drawing. Our variant layout approach allows edges to cross if they appear in dierent graphs.
['Ulrik Brandes', 'Tim Dwyer', 'Falk Schreiber']
Visual Understanding of Metabolic Pathways Across Organisms Using Layout in Two and a Half Dimensions