Background#R##N#It has recently been shown that fractionation, the random loss of excess gene copies after a whole genome duplication event, is a major cause of gene order disruption. When estimating evolutionary distances between genomes based on chromosomal rearrangement, fractionation inevitably leads to significant overestimation of classic rearrangement distances. This bias can be largely avoided when genomes are preprocessed by "consolidation", a procedure that identifies and accounts for regions of fractionation.
['K. Jahn', 'Chunfang Zheng', 'Jakub Kováč', 'David Sankoff']
A consolidation algorithm for genomes fractionated after higher order polyploidization