A metabolic genotype comprises all chemical reactions an organism can catalyze via enzymes encoded in its genome. A genotype is viable in a given environment if it is capable of producing all biomass components the organism needs to survive and reproduce. Previous work has focused on the properties of individual genotypes while little is known about how genome-scale metabolic networks with a given function can vary in their reaction content.
['Areejit Samal', 'João F. Matias Rodrigues', 'Jürgen Jost', 'Olivier C. Martin', 'Andreas Wagner']
Genotype networks in metabolic reaction spaces