Much progress has been made in validating closed loop glucose control strategies have drastically improved over the last decade. Reactive control strategies such as PID algorithms have been largely replaced by a new wave of model predictive control (MPC) designs which utilize a model of patient metabolic system and employ a look-ahead strategy to anticipate changes in blood glucose levels. Most recently, the concept of modular approach to artificial pancreas (AP) design has been introduced. This allows for the seamless integration of different technologies in a functional hierarchical system that can be sequentially deployed in clinical and ambulatory studies. With this architecture in place, various increasingly complex configurations of an AP system become possible. This paper focuses on the efforts made to create a modular hardware-in-the loop platform and design methodology for validating closed loop glucose control systems.
['Ari J. G. Ramdial', 'Zeljko Zilic']
Design of a modeling and validation platform for closed loop glucose control