Motivation: Long QT syndromes (LQTS) are characterized by early afterdepolarizations (EADs), repolarization dispersion and tachyarrhythmias. However, mechanisms by which these substrates promote tachyarrhythmias remain to be fully elucidated. This study sought to test the hypothesis that EADs induced by abrupt rate accelerations can occur and investigate how this abrupt rate accelerations is related to the mechanisms of reentrant excitations.
['Jieyun Bai', 'Kuanquan Wang', 'Henggui Zhang']
Multi-scale cardiac modelling reveal tachyarrhythmias induced by abrupt rate accelerations in long QT syndrome