Background#R##N#Distinction between true protein interactions and crystal packing contacts is important for structural bioinformatics studies to respond to the need of accurate classification of the rapidly increasing protein structures. There are many unannotated crystal contacts and there also exist false annotations in this rapidly expanding volume of data. Previous tools have been proposed to address this problem. However, challenging issues still remain, such as low performance when the training and test data contain mixed interfaces having diverse sizes of contact areas.
['Qian Liu', 'Zhenhua Li', 'Jinyan Li']
Use B-factor related features for accurate classification between protein binding interfaces and crystal packing contacts