Background#R##N#High Content Screening (HCS) has become an important tool for toxicity assessment, partly due to its advantage of handling multiple measurements simultaneously. This approach has provided insight and contributed to the understanding of systems biology at cellular level. To fully realize this potential, the simultaneously measured multiple endpoints from a live cell should be considered in a probabilistic relationship to assess the cell's condition to response stress from a treatment, which poses a great challenge to extract hidden knowledge and relationships from these measurements.
['Halil Bisgin', 'Minjun Chen', 'Yuping Wang', 'Reagan Kelly', 'Hong Fang', 'Xiaowei Xu', 'Weida Tong']
A systems approach for analysis of high content screening assay data with topic modeling