Background#R##N#In cell differentiation, a less specialized cell differentiates into a more specialized one, even though all cells in one organism have (almost) the same genome. Epigenetic factors such as histone modifications are known to play a significant role in cell differentiation. We previously introduce cell-type trees to represent the differentiation of cells into more specialized types, a representation that partakes of both ontogeny and phylogeny.
['Nishanth Ulhas Nair', 'Laura Hunter', 'Mingfu Shao', 'Paulina Grnarova', 'Yu Lin', 'Philipp Bucher', 'Bernard M. E. Moret']
A maximum-likelihood approach for building cell-type trees by lifting