In clinical practice at Tibetan area of China, Traditional Tibetan Medicine formula Wuwei-Ganlu-Yaoyu-Keli(WGYK) is widely added in warm water of bath therapy to treat rheumatoid arthritis (RA). However, its action mechanism is not well interpreted yet. In this study, based on gene expression data from microarray experiments, we apply approaches of network pharmacology to further reveal the action mechanism that WGYK exerts on RA from perspective of protein-protein interactions and pathways. This study may facilitate our understanding of anti-RA effect of WGYK from perspective of network pharmacology.
['Jian Yang', 'Tianhong Wang', 'Xiaona Shen', 'Xing Chen', 'Kehui Zhao', 'Jing Wang', 'Yi Zhang', 'Jing Zhao', 'Yang Ga']
Network based study for the anti-rheumatic mechanism of Tibetan medicated-bath therapy