Background#R##N#The National Institute of Allergy and Infectious Diseases has launched the HIV-1 Human Protein Interaction Database in an effort to catalogue all published interactions between HIV-1 and human proteins. In order to systematically investigate these interactions functionally and dynamically, we have constructed an HIV-1 human protein interaction network. This network was analyzed for important proteins and processes that are specific for the HIV life-cycle. In order to expose viral strategies, network motif analysis was carried out showing reoccurring patterns in virus-host dynamics.
['David van Dijk', 'Gokhan Ertaylan', 'Charles A. Boucher', 'Peter M. A. Sloot']
Identifying potential survival strategies of HIV-1 through virus-host protein interaction networks