Background#R##N#Dysregulation of genetic factors such as microRNAs (miRNAs) and mRNAs has been widely shown to be associated with cancer progression and development. In particular, miRNAs and mRNAs cooperate to affect biological processes, including tumorigenesis. The complexity of miRNA-mRNA interactions presents a major barrier to identifying their co-regulatory roles and functional effects. Thus, by computationally modeling these complex relationships, it may be possible to infer the gene interaction networks underlying complicated biological processes.
['Soo-Jin Kim', 'Jung-Woo Ha', 'Byoung-Tak Zhang']
Constructing higher-order miRNA-mRNA interaction networks in prostate cancer via hypergraph-based learning