Summary: With the continuous growth of the RCSB Protein Data Bank (PDB), providing an up-to-date systematic structure comparison of all protein structures poses an ever growing challenge. Here, we present a comparison tool for calculating both 1D protein sequence and 3D protein structure alignments. This tool supports various applications at the RCSB PDB website. First, a structure alignment web service calculates pairwise alignments. Second, a stand-alone application runs alignments locally and visualizes the results. Third, pre-calculated 3D structure comparisons for the whole PDB are provided and updated on a weekly basis. These three applications allow users to discover novel relationships between proteins available either at the RCSB PDB or provided by the user.#R##N##R##N#Availability and Implementation: A web user interface is available at http://www.rcsb.org/pdb/workbench/workbench.do. The source code is available under the LGPL license from http://www.biojava.org. A source bundle, prepared for local execution, is available from http://source.rcsb.org#R##N##R##N#Contact:andreas@sdsc.edu; pbourne@ucsd.edu
['Andreas Prlić', 'Spencer Bliven', 'Peter W. Rose', 'Wolfgang F. Bluhm', 'Chris Bizon', 'Adam Godzik', 'Philip E. Bourne']
Pre-calculated protein structure alignments at the RCSB PDB website