Motivated by known preferences for certain amino acids in positions around a-helices, we developed neural network-based predictors of both N and C a-helix ends, which achieved about 88% accuracy. We applied a similar approach for predicting the ends of three types of secondary structure segments. The predictors for the ends of H, E and C segments were then used to create input for protein secondary-structure prediction. By incorporating this new type of input, we significantly improved the basic one-stage predictor of protein secondary structure in terms of both per-residue (Q 3 ) accuracy (+0.8%) and segment overlap (SOV 3 ) measure (+1.4).
['Uros Midic', 'Axel Dunker', 'Zoran Obradovic']
Improving Protein Secondary-Structure Prediction by Predicting Ends of Secondary-Structure Segments