Background#R##N#Warfarin is the most widely prescribed anticoagulant for the prevention and treatment of thromboembolic events. Although highly effective, the use of warfarin is limited by a narrow therapeutic range combined with a more than ten-fold difference in the dose required for adequate anticoagulation in adults. An optimal dose that leads to a favourable balance between the wanted antithrombotic effect and the risk of bleeding as measured by the prothrombin time International Normalised Ratio (INR) must be found for each patient. A model describing the time-course of the INR response can be used to aid dose selection before starting therapy (a priori dose prediction) and after therapy has been initiated (a posteriori dose revision).
['Anna-Karin Hamberg', 'Jacob Hellman', 'Jonny Dahlberg', 'E. Niclas Jonsson', 'Mia Wadelius']
A Bayesian decision support tool for efficient dose individualization of warfarin in adults and children