text: How long does malaria stay in your system?
  CEREBRAL MALARIA LONG-TERM EFFECTS
  The effects of malaria infection on the body can be
  profound, resulting in long-term health effects ranging from increased
  susceptibility to bacterial infection to cognitive decline. Even though some of
  these negative consequences are well-known for the most serious types
  of disease, emerging evidence suggests that this is just the beginning.
  According to specialists in the condition, immunity to the
  parasite develops with exposure to the illness, enabling apparently healthy
  people to regulate but not cure their sickness. Treatment is not sought because
  they no longer experience fever. The ensuing hidden, chronic infection not only
  adds to the spread of malaria but also gradually worsens people's health and
  ability to develop normally.
  Acute organ failures, aberrant blood cell counts, and
  metabolic dysfunctions, both alone or in combination, are at the other extreme
  of the disease spectrum and cause severe malaria when infections are compounded
  by them. Even with the proper medications available, mortality remains high.
  Adding to the confusion, the WHO World Malaria Report for this year notes that
  it can be difficult to properly identify severe malaria cases, especially in
  places with few clinical and laboratory capabilities.
  Malaria infection can cause severe neurological
  complications, the most serious of which is cerebral malaria. Sub-Saharan
  African children are the most afflicted, and those who survive frequently have
  lifelong conditions that can significantly lower their quality of life. These
  conditions include epilepsy, attention deficit hyperactivity disorder, and
  impairments of cognitive, and motor, including visual coordination.
  An obvious clinical sign of cerebral malaria is a coma that
  advances quickly. Using age-specific coma scores with distinct cutoffs for kids
  and adults, this neurological condition is identified. At the moment, it is
  indicated by an adult Glasgow Coma Score of 11 or less (indicating a moderate
  to severe brain injury) and a kid Blantyre Coma Score of 3 or less.
  Surprisingly, recent research in Ugandan children revealed
  that some of these long-term neurological consequences are also present in
  cases of cerebral malaria without a clinically diagnosed disease. The impact on
  the brain can occur regardless of the patient's level of consciousness,
  according to these unexpected new results. But since less research has been
  done on adults, there is far less information available.
  This motivated our team to look into the occurrence of
  cerebral malaria-related brain alterations in patients who weren't in a coma.
  For malaria patients to receive better care and have better outcomes, it was
  essential to close this knowledge gap.s
  Our current research, funded by the US National Institutes of Health and published in Clinical Infectious Diseases, makes the first-ever claim that unsuspected brain alterations are frequently brought on by malaria infections brought on by the Plasmodium falciparum parasite.
  These results imply that a significant number of malaria
  patients may be suffering brain damage that goes unrecognized because they
  don't meet the diagnostic thresholds currently in place. This emphasizes the
  need for fresh approaches to finding cases with "silent" cerebral
  malaria and enhancing their paths for treatment.
  We assessed the effects of P. falciparum infection on the
  brains of adult malaria patients in India who did not meet the diagnostic
  criteria for cerebral malaria using magnetic resonance imaging (MRI) scans of
  the individuals. These included individuals with simple malaria cases and
  people who had serious organ damage outside of the brain. We used a
  cutting-edge method to detect minute brain changes, and we were startled to
  find that both groups of infected people had varying degrees of brain damage.
  Notwithstanding the absence of coma, the severe cases
  without obvious neurological consequences had a wide spectrum of brain
  alterations on MRI, with the most obvious findings resembling those we have
  previously seen in cerebral malaria. In addition, we discovered that compared
  to straightforward instances, this group exhibited increased plasma levels of
  S100B, a well-known marker of brain injury frequently linked to long-term
  THESE FINDINGS HAVE SIGNIFICANT IMPLICATIONS.
  They first question our current clinical definition of
  cerebral malaria because all adult patients with substantial MRI-detected brain
  abnormalities are not included in the Glasgow Coma Score cutoff of 11 or less.
  From this perspective, it's significant to note that the WHO
  recently raised the threshold for adult cerebral malaria from 9 and below,
  where it had previously been placed. Despite this modification, a large number
  of adult patients who do not meet the stringent diagnosis nonetheless have
  cerebral involvement and may be at risk of developing post-infection
  Although MRI scans are far more accurate at detecting
  cerebral damage caused by severe malaria, neuroimaging facilities are rarely
  accessible in regions where the disease is widespread, such as Africa or
  Southeast Asia. Therefore, new methods are required, such as biomarkers linked
  to potentially detrimental brain alterations seen on MRI, in order to quickly
  and accurately identify patients with silent cerebral malaria.
  Additionally, and perhaps more crucially, it is unknown at
  this time whether these modifications will have short- or long-term consequences
  on neurological and cognitive processes following infection. The potential of
  modest but long-lasting problems, which have never been evaluated in this
  patient population, is strongly suggested by the combination of cerebral
  malaria-like MRI patterns and high plasma levels of a brain damage marker.
  We urgently require investigations evaluating the magnitude
  and significance of brain alterations in adult patients with severe P.
  falciparum infection who are not in a coma in light of this new report in order
  to inform and create effective techniques to identify people at risk and aid in
  their recovery and rehabilitation.
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  - Malaria symptoms
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  - Cerebral malaria
  - Types of malaria and their symptoms
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