Key Signature Genes of Early Terminal Granulocytic Differentiation Distinguish Sepsis from SIRS on ICU Admission
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully.  <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'Background: Infection can induce granulopoiesis. This process potentially gives rise to blood gene classifiers of sepsis in systemic inflammatory response syndrome (SIRS) patients. The aim of this study was to identify sepsis signature genes in blood granulocytes from patients with sepsis and SIRS on intensive care unit (ICU) admission.Methods: CD15+ cells encompassing all stage of terminal granulocytic differentiation were analyzed. CD15 transcriptomes from patients with sepsis and SIRS on ICU admission and presurgical controls (discovery cohort) were subjected to differential gene expression and pathway enrichment analyses. Differential expression was validated by bead array in independent sepsis and SIRS patients (validation cohort). We referred to the GeneCards database for subcellular gene associations and Grassi et al. (Cell Rep ' . Please return only a json list of at most 3 Keywords corresponding to the Description:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> {"Answer" : ["granulocytes","intensive care unit","sepsis","signature genes","systemic inflammatory response syndrome"]} <|eot_id|>
 Here is the Description of a dataset. Description:'Background: Infection can induce granulopoiesis. This process potentially gives rise to blood gene classifiers of sepsis in systemic inflammatory response syndrome (SIRS) patients. The aim of this study was to identify sepsis signature genes in blood granulocytes from patients with sepsis and SIRS on intensive care unit (ICU) admission.Methods: CD15+ cells encompassing all stage of terminal granulocytic differentiation were analyzed. CD15 transcriptomes from patients with sepsis and SIRS on ICU admission and presurgical controls (discovery cohort) were subjected to differential gene expression and pathway enrichment analyses. Differential expression was validated by bead array in independent sepsis and SIRS patients (validation cohort). We referred to the GeneCards database for subcellular gene associations and Grassi et al. (Cell Rep ' . Please return only a json list of at most 3 Keywords corresponding to the Description:.
Background: Infection can induce granulopoiesis. This process potentially gives rise to blood gene classifiers of sepsis in systemic inflammatory response syndrome (SIRS) patients. The aim of this study was to identify sepsis signature genes in blood granulocytes from patients with sepsis and SIRS on intensive care unit (ICU) admission.Methods: CD15+ cells encompassing all stage of terminal granulocytic differentiation were analyzed. CD15 transcriptomes from patients with sepsis and SIRS on ICU admission and presurgical controls (discovery cohort) were subjected to differential gene expression and pathway enrichment analyses. Differential expression was validated by bead array in independent sepsis and SIRS patients (validation cohort). We referred to the GeneCards database for subcellular gene associations and Grassi et al. (Cell Rep 
granulocytes; intensive care unit; sepsis; signature genes; systemic inflammatory response syndrome