Replication Data for: 'Lulworthinone: In vitro mode of action investigation of an antibacterial dimeric naphthopyrone isolated from a marine fungus.'
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully.  <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'Treatment options for infections caused by antimicrobial-resistant bacteria are rendered ineffective, and drug alternatives are needed - either from new chemical classes or drugs with new modes of action.Historically, natural products have been important contributors to drug discovery. The search for new antimicrobials from marine fungi led to the discovery of the dimeric naphthopyrone lulworthinone produced by an obligate marine fungus in the family Lulworthiaceae (Jenssen et al. ,2021).The observed potent antibacterial activity against Gram positive bacteria, including several clinical methicillin-resistant _Staphylococcus aureus_ (MRSA) isolates, promoted this follow-up mode of action investigation.Lulworthinone treatment induced an upregulation of genes responding to cell envelope stress in Bacillus subtilis. Further in vitr' . Please return only a json list of at most 3 Keywords corresponding to the Description:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> {"Answer" : ["antimicrobial agent","B. subtilis","CCCCCC1Cc3c(C(=O)O1)c(O)c2c(O)cc(OS(=O)(=O)O)cc2c3c6c(OC)cc5cc4c(C(=O)O[C@H](CCCCC)[C@H]4O)c(O)c5c6O","CCCCC[C@@H]1Cc3c(C(=O)O1)c(O)c2c(O)cc(O)cc2c3c6c(O)c5c(O)c4C(=O)O[C@H](CCCCC)[C@H](OS(=O)(=O)[O-])c4cc5cc6OC","colloidal aggregate","FtsZ","marine natural product","mode of action","MRSA"]} <|eot_id|>
 Here is the Description of a dataset. Description:'Treatment options for infections caused by antimicrobial-resistant bacteria are rendered ineffective, and drug alternatives are needed - either from new chemical classes or drugs with new modes of action.Historically, natural products have been important contributors to drug discovery. The search for new antimicrobials from marine fungi led to the discovery of the dimeric naphthopyrone lulworthinone produced by an obligate marine fungus in the family Lulworthiaceae (Jenssen et al. ,2021).The observed potent antibacterial activity against Gram positive bacteria, including several clinical methicillin-resistant _Staphylococcus aureus_ (MRSA) isolates, promoted this follow-up mode of action investigation.Lulworthinone treatment induced an upregulation of genes responding to cell envelope stress in Bacillus subtilis. Further in vitr' . Please return only a json list of at most 3 Keywords corresponding to the Description:.
Treatment options for infections caused by antimicrobial-resistant bacteria are rendered ineffective, and drug alternatives are needed - either from new chemical classes or drugs with new modes of action.Historically, natural products have been important contributors to drug discovery. The search for new antimicrobials from marine fungi led to the discovery of the dimeric naphthopyrone lulworthinone produced by an obligate marine fungus in the family Lulworthiaceae (Jenssen et al. ,2021).The observed potent antibacterial activity against Gram positive bacteria, including several clinical methicillin-resistant _Staphylococcus aureus_ (MRSA) isolates, promoted this follow-up mode of action investigation.Lulworthinone treatment induced an upregulation of genes responding to cell envelope stress in Bacillus subtilis. Further in vitr
antimicrobial agent; B. subtilis; CCCCCC1Cc3c(C(=O)O1)c(O)c2c(O)cc(OS(=O)(=O)O)cc2c3c6c(OC)cc5cc4c(C(=O)O[C@H](CCCCC)[C@H]4O)c(O)c5c6O; CCCCC[C@@H]1Cc3c(C(=O)O1)c(O)c2c(O)cc(O)cc2c3c6c(O)c5c(O)c4C(=O)O[C@H](CCCCC)[C@H](OS(=O)(=O)[O-])c4cc5cc6OC; colloidal aggregate; FtsZ; marine natural product; mode of action; MRSA