Replication Data for: 'epialleleR: an R/BioC package for quantifying and analysing low-frequency DNA methylation'
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully.  <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'AbstractConstitutional epigenetic silencing of tumour suppressor genes has been detected in a small number of cancer patients. Recent finding have indicated that low-level mosaic methylation of the BRCA1 gene promoter occurs in 5-10% of healthy individuals and is associated with a significantly elevated risk of breast and ovarian cancer. This further suggests that similar mosaic constitutional methylation may occur in other tumour suppressor genes as well, potentially being a significant contributor to cancer burden. However, detection of low-level mosaic epigenetic events requires highly sensitive and robust methodology for methylation analysis.We here present epialleleR, a computational framework for sensitive detection, quantification and visualisation of low-frequency, mosaic epimutation' . Please return only a json list of at most 3 Keywords corresponding to the Description:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> {"Answer" : ["Computational Biology","DNA methylation","epialleleR","Epigenomics"]} <|eot_id|>
 Here is the Description of a dataset. Description:'AbstractConstitutional epigenetic silencing of tumour suppressor genes has been detected in a small number of cancer patients. Recent finding have indicated that low-level mosaic methylation of the BRCA1 gene promoter occurs in 5-10% of healthy individuals and is associated with a significantly elevated risk of breast and ovarian cancer. This further suggests that similar mosaic constitutional methylation may occur in other tumour suppressor genes as well, potentially being a significant contributor to cancer burden. However, detection of low-level mosaic epigenetic events requires highly sensitive and robust methodology for methylation analysis.We here present epialleleR, a computational framework for sensitive detection, quantification and visualisation of low-frequency, mosaic epimutation' . Please return only a json list of at most 3 Keywords corresponding to the Description:.
AbstractConstitutional epigenetic silencing of tumour suppressor genes has been detected in a small number of cancer patients. Recent finding have indicated that low-level mosaic methylation of the BRCA1 gene promoter occurs in 5-10% of healthy individuals and is associated with a significantly elevated risk of breast and ovarian cancer. This further suggests that similar mosaic constitutional methylation may occur in other tumour suppressor genes as well, potentially being a significant contributor to cancer burden. However, detection of low-level mosaic epigenetic events requires highly sensitive and robust methodology for methylation analysis.We here present epialleleR, a computational framework for sensitive detection, quantification and visualisation of low-frequency, mosaic epimutation
Computational Biology; DNA methylation; epialleleR; Epigenomics