Common variants associated with OSMR expression contribute to carotid plaque vulnerability, but not to cardiovascular disease in humans
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully.  <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'This dataset pertains to the data used for the article 'van Keulen D et al. Common variants associated with OSMR expression contribute to carotid plaque vulnerability, but not to cardiovascular disease in humans. 2021'; below the abstract.Background and aims Oncostatin M (OSM) signaling is implicated in atherosclerosis, however the mechanism remains unclear. We investigated the impact of common genetic variants in OSM and its receptors, OSMR and LIFR, on overall plaque vulnerability, plaque phenotype, intraplaque OSMR and LIFR expression, coronary artery calcification burden and cardiovascular disease susceptibility.Methods and results We queried Genotype-Tissue Expression data and found that rs13168867 (C allele) was associated with decreased OSMR</em' . Please return only a json list of at most 3 Keywords corresponding to the Description:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> {"Answer" : ["atherosclerosis","eQTL","genetics","OSMR"]} <|eot_id|>
 Here is the Description of a dataset. Description:'This dataset pertains to the data used for the article 'van Keulen D et al. Common variants associated with OSMR expression contribute to carotid plaque vulnerability, but not to cardiovascular disease in humans. 2021'; below the abstract.Background and aims Oncostatin M (OSM) signaling is implicated in atherosclerosis, however the mechanism remains unclear. We investigated the impact of common genetic variants in OSM and its receptors, OSMR and LIFR, on overall plaque vulnerability, plaque phenotype, intraplaque OSMR and LIFR expression, coronary artery calcification burden and cardiovascular disease susceptibility.Methods and results We queried Genotype-Tissue Expression data and found that rs13168867 (C allele) was associated with decreased OSMR</em' . Please return only a json list of at most 3 Keywords corresponding to the Description:.
This dataset pertains to the data used for the article 'van Keulen D et al. Common variants associated with OSMR expression contribute to carotid plaque vulnerability, but not to cardiovascular disease in humans. 2021'; below the abstract.Background and aims Oncostatin M (OSM) signaling is implicated in atherosclerosis, however the mechanism remains unclear. We investigated the impact of common genetic variants in OSM and its receptors, OSMR and LIFR, on overall plaque vulnerability, plaque phenotype, intraplaque OSMR and LIFR expression, coronary artery calcification burden and cardiovascular disease susceptibility.Methods and results We queried Genotype-Tissue Expression data and found that rs13168867 (C allele) was associated with decreased OSMR</em
atherosclerosis; eQTL; genetics; OSMR