The League of Extraordinary Gentlemen ( film ) - wikipedia The League of Extraordinary Gentlemen ( film ) Jump to : navigation , search The League of Extraordinary Gentlemen Theatrical release poster Directed by Stephen Norrington Produced by Trevor Albert Rick Benattar Sean Connery Mark Gordon Don Murphy Michael Nelson Screenplay by James Dale Robinson Based on The League of Extraordinary Gentlemen by Alan Moore Kevin O'Neill Starring Sean Connery Shane West Stuart Townsend Peta Wilson Jason Flemyng Music by Trevor Jones Cinematography Dan Laustsen Edited by Paul Rubell Production companies 20th Century Fox Angry Films International Production Company JD Productions Distributed by 20th Century Fox Release date July 11 , 2003 ( 2003 - 07 - 11 ) Running time 110 minutes Country United Kingdom Germany Czech Republic United States Language English Budget $78 million Box office $179.3 million The League of Extraordinary Gentlemen , also promoted as LXG , is a 2003 steampunk - dieselpunk superhero action film loosely based on the first volume of the comic book series of the same name by Alan Moore and Kevin O'Neill . It was released on July 11 , 2003 , in the United States , and distributed by 20th Century Fox . It was directed by Stephen Norrington and starred Sean Connery , Naseeruddin Shah , Peta Wilson , Tony Curran , Stuart Townsend , Shane West , Jason Flemyng , and Richard Roxburgh . As with the comic book source material , the film features prominent pastiche and crossover themes set in the late 19th century , featuring an assortment of fictional literary characters appropriate to the period , who act as Victorian Era superheroes . It draws on the works of Jules Verne , H.G. Wells , Bram Stoker , Sir Arthur Conan Doyle , H. Rider Haggard , Ian Fleming , Herman Melville , Oscar Wilde , Robert Louis Stevenson , Edgar Allan Poe , Gaston Leroux , and Mark Twain , albeit all adapted for the film . The film grossed over $175 million worldwide at the box office , rental revenue of $48.6 million , and DVD sales as of 2003 at $36.4 million . It was intended to spawn a film franchise based on further titles in the original comic book series but there was little enthusiasm for a sequel . The film marked Sean Connery 's last on - screen film appearance before his retirement . Contents ( hide ) 1 Plot 2 Cast 3 Production 3.1 Writing 3.2 Casting 3.3 Filming 4 Lawsuit 5 Reception 5.1 Box office 5.2 Critical response 5.3 Creators ' response 6 In other media 7 Reboot 8 See also 9 References 10 External links Plot ( edit ) In 1899 , a terrorist group led by the Fantom cause international tension , breaking into the Bank of England to steal Leonardo da Vinci 's blueprints of Venice 's foundations , and then kidnap German scientists . The British Empire sends Sanderson Reed to Kenya to recruit adventurer and hunter Allan Quatermain . Quatermain , retired following the death of his son , at first refuses until a group of assassins are sent to kill him . In London , Quatermain meets `` M '' , who is forming the latest generation of the League of Extraordinary Gentlemen . He reveals the Fantom plans to start a world war by bombing a secret meeting of world leaders in Venice . The new League consists of Quatermain , Captain Nemo , vampiric chemist Mina Harker , and invisible thief Rodney Skinner . The League travel to the London docks to recruit Dorian Gray , Mina 's former lover who is kept immortal thanks to a missing portrait . The Fantom 's assassins attack , but the League fend them off , aided by U.S. Secret Service Agent Tom Sawyer . Dorian and Sawyer join the League . They then capture Edward Hyde in Paris and he joins the League after being offered amnesty , transforming back into his alter ego Dr. Jekyll . The League travel for Venice in Nemo 's submarine , the Nautilus , but it soon becomes clear there may be a mole on board : A camera 's flash powder residue is found in the wheelhouse , and one of Jekyll 's transformation formulas disappears . Suspicion falls on the missing Skinner . The Nautilus arrives in Venice just as the bombs go off , causing the city to start collapsing in a domino effect . Sawyer uses Nemo 's automobile to stop the destruction , while Quatermain confronts the Fantom , who is unmasked as M. Dorian is also revealed to be the traitor , murders Nemo 's first mate Ishmael , and steals the Nautilus ' exploration pod . M and Dorian leave a phonograph recording for the League , revealing that their true goal is to ignite the world war and Dorian has been collecting physical elements of the League to create superhuman formulas and sell them off to the highest bidder . The Nautilus is damaged by bombs hidden on board , but Hyde saves it by draining the flooded engine rooms . Skinner sends a message to the League , revealing he has sneaked aboard the exploration pod and telling them to follow his heading . The League reach northern Mongolia , reuniting with Skinner , where they plot to destroy M 's factory with explosives . Nemo and Hyde rescue the scientists , Skinner sets the explosive charges , while Mina battles Dorian , killing him by exposing him to his portrait . Quatermain and Sawyer confront M , identifying him as Professor James Moriarty , who took on a new alias after his alleged death at the Reichenbach Falls . Sawyer is taken hostage by an invisible Reed ; Quatermain shoots the latter , only for Moriarty to fatally stab him . Moriarty flees outside , but Sawyer successfully shoots him , and the formulas sink into the icy water . Quatermain then dies . Quatermain is buried beside his son in Kenya . The surviving League members recall how a witch doctor had blessed Quatermain for saving his village , promising that Africa would never let him die . The remaining League members depart agreeing to continue using their powers for good in the new century . Then the witch doctor arrives , performing a ritual that summons an unnatural storm , with a bolt of lightning ambiguously striking the rifle Sawyer left on Quatermain 's grave . Cast ( edit ) Sean Connery as Allan Quatermain Naseeruddin Shah as Captain Nemo Shane West as Tom Sawyer Stuart Townsend as Dorian Gray Peta Wilson as Wilhelmina `` Mina '' Harker Jason Flemyng as Dr. Henry Jekyll / Edward Hyde Tony Curran as Rodney Skinner / The Invisible Man II Richard Roxburgh as Professor James Moriarty / Fantom / M David Hemmings as Nigel Max Ryan as Dante Tom Goodman - Hill as Sanderson Reed Terry O'Neill as Ishmael Production ( edit ) Writing ( edit ) For the script , the character `` The Invisible Man '' was changed to `` An Invisible Man '' since Fox was unable to obtain the rights to the title character of H.G. Wells ' The Invisible Man , and his name was changed from `` Hawley Griffin '' to `` Rodney Skinner '' . The Fu Manchu character was also dropped from the script . At Fox 's request , the character of Tom Sawyer was added for American audiences and to give the movie some `` youth appeal '' . Producer Don Murphy , who described the request as a `` stupid studio note '' , later said that the move to add Sawyer was `` brilliant '' . Casting ( edit ) Connery was paid USD $17 million for his role , which left the filmmakers little money to attract other big - name stars for the ensemble cast . A character named Eva Draper ( Winter Ave Zoli ) , the daughter of German scientist Karl Draper , was removed during editing but remained in some of the promotional material . Eva had appeared in two scenes : one ended up on the cutting room floor , and she was digitally replaced with a different character in the other . A brief fight scene featuring Tom Sawyer and the replacement character was rotoscoped into the film . The deleted scenes which feature Draper appear on the DVD . Filming ( edit ) Principal photography took place in Hungary , Malta , and the Czech Republic . Connery reportedly had many disputes with director Stephen Norrington . Norrington did not attend the opening party , and when was asked where the director could be , Connery is said to have replied , `` Check the local asylum . '' Norrington reportedly did not like the studio supervision and was `` uncomfortable '' with large crews . The studio put pressure on the filmmakers for a summer release . Some staff at Fox wanted it to be released in the fall , but according to the Los Angeles Times , Fox already had Master and Commander lined up for the fall . The production ran into trouble when a special effects set did not pan out as intended , forcing the filmmakers to have to quickly look for another effects shop . Lawsuit ( edit ) In 2003 , Larry Cohen and Martin Poll filed a lawsuit against 20th Century Fox , claiming the company had intentionally plagiarized their script Cast of Characters . According to the BBC , the lawsuit alleged `` that Mr Cohen and Mr Poll pitched the idea to Fox several times between 1993 and 1996 , under the name Cast of Characters , '' and that Fox had solicited the comics series The League of Extraordinary Gentlemen as a smoke screen . It noted that the films shared public domain characters who did not appear in the comic book series . Although Fox denied the allegations as `` absurd nonsense '' , the case was settled out of court , a decision Alan Moore , according to The New York Times `` took ... as an especially bitter blow , believing that ( he ) had been denied the chance to exonerate ( himself ) . '' Reception ( edit ) Box Office ( edit ) The film opened at # 2 behind Pirates of the Caribbean : The Curse of the Black Pearl . The League of Extraordinary Gentlemen grossed an estimated $66,465,204 in Canada and the United States , $12,603,037 in the United Kingdom , and $12,033,033 in Spain . Worldwide , the film took $179,265,204 . Critical response ( edit ) Critical reaction to the film was generally unfavorable , with Empire magazine giving it two stars out of five while criticizing the film 's exposition and lack of character depth , saying it ' flirts dangerously close with one - star ignominy ' . A 30 / 100 approval rating on Metacritic is based on 36 reviews . Rotten Tomatoes reports 17 % of 177 reviews being positive , with an average rating of 4 / 10 . Roger Ebert of the Chicago Sun - Times gave the film one star out of a possible four stating `` The League of Extraordinary Gentlemen assembles a splendid team of heroes to battle a plan for world domination , and then , just when it seems about to become a real corker of an adventure movie , plunges into ... inexplicable motivations , causes without effects , effects without causes , and general lunacy . '' Creators ' response ( edit ) In an interview with The Times , Kevin O'Neill , illustrator of the comics , said he believed the film failed because it was not respectful of the source material . He did not recognize the characters when reading the screenplay and claimed that Norrington and Connery did not cooperate . Finally , O'Neill said that the comic book version of Allan Quatermain was a lot better than the movie version and that marginalising Mina Murray as a vampire `` changed the whole balance '' . The author of the comics Alan Moore was cynical of the film from early in its development , seeing that the two works bore little resemblance , distancing himself from the film altogether . `` As long as I could distance myself by not seeing them , '' he said , he could profit from the films while leaving the original comics untouched , `` assured no one would confuse the two . This was probably naïve on my part . '' In other media ( edit ) The League of Extraordinary Gentlemen earned a total of $48,640,000 in rentals with $14,810,000 from video rentals and $33,830,000 from DVD rentals . DVD sales meanwhile gathered revenue of $36,400,000 . A novelization of the movie was written by Kevin J. Anderson and released shortly before the movie . The soundtrack album was also released internationally but not in the United States . Reboot ( edit ) The Tracking Board reported on May 26 , 2015 , that 20th Century Fox and Davis Entertainment had agreed to develop a reboot with hopes of launching a franchise . The report stated that a search was underway for a director who could help `` continue to develop the reboot . '' John Davis told Collider in an interview that the reboot will be a female centric film . See also ( edit ) Penny Dreadful - a Showtime series involving famous figures from literary horror . Anno Dracula - a mashup novel by Kim Newman Bungou Stray Dogs - a Japanese manga with a similar premise . References ( edit ) Jump up ^ `` THE LEAGUE OF EXTRAORDINARY GENTLEMEN ( 12A ) '' . British Board of Film Classification . July 11 , 2003 . Retrieved August 16 , 2015 . Jump up ^ `` The League of Extraordinary Gentlemen '' . British Film Institute . London . Retrieved November 10 , 2012 . ^ Jump up to : `` The League of Extraordinary Gentlemen ( 2003 ) -- Box Office Mojo '' . boxofficemojo.com . Jump up ^ Tobey , Matthew . `` The League of Extraordinary Gentlemen '' . Allmovie . Retrieved November 10 , 2012 . Jump up ^ `` The Numbers : Box Office Data '' . Retrieved October 4 , 2014 . ^ Jump up to : John Horn . `` Heroic effort ? ; Audiences are the last hurdle for a beleaguered ' League ' '' . July 14 , 2003 , Los Angeles Times , Page E1 . Jump up ^ `` Movies ; Hungary plans huge studio , luring film world : ( HOME EDITION ) . '' Los Angeles Times ( Los Angeles , Calif . ) June 4 , 2004 , E. 13 . Los Angeles Times . Jump up ^ Bill Desowitz . `` Movies ; Bonds , James Bonds ; Sean Connery , George Lazenby , Roger Moore , Timothy Dalton and Pierce Brosnan : 007s who 've saved the world in her majesty 's service : ( HOME EDITION ) . '' Los Angeles Times . November 17 , 2002 , E. 6 . Los Angeles Times . Jump up ^ Cameron , Stuart ( 30 September 2004 ) . `` Has Sean Made His Last Movie ? : Mystery as 007 Legend Quits Film Role '' , Daily Mirror ( SCOTS Edition ) , London ( UK ) , Page 9 . ^ Jump up to : `` Gentlemen lands Fox in $100 m lawsuit '' , Saturday , September 27 , 2003 . Calcutta Telegraph . ^ Jump up to : `` Producer and Writer File $100 Million Lawsuit Against 20th Century - Fox '' , September 25 , 2003 . Business Wire . Archived on 2008 - 05 - 28 . ^ Jump up to : `` Studio sued over superhero movie '' . BBC . September 26 , 2003 . Archived from the original on May 16 , 2008 . Retrieved May 16 , 2008 . CS1 maint : BOT : original - url status unknown ( link ) on 2008 - 05 - 16 . Jump up ^ Barber , Nicholas , `` Notices : Cinema opening this week '' . The Independent on Sunday ( London ) ; October 26 , 2003 ; p. 39 Jump up ^ Itzkoff , David ( March 12 , 2006 ) . `` The Vendetta Behind ' V for Vendetta ' '' . New York Times . Retrieved 2008 - 05 - 16 . Jump up ^ `` The League of Extraordinary Gentlemen '' . Box Office Mojo . Retrieved 2011 - 05 - 17 . Jump up ^ `` The League of Extraordinary Gentlemen -- Foreign Gross '' . Box Office Mojo . Retrieved 2011 - 05 - 17 . Jump up ^ `` The League of Extraordinary Gentlemen '' . Empire magazine . Retrieved 2011 - 05 - 17 . Jump up ^ `` The League of Extraordinary Gentlemen '' . Metacritic . Retrieved 2011 - 05 - 17 . Jump up ^ `` The League of Extraordinary Gentlemen '' . Rotten Tomatoes . Flixster . Retrieved 2011 - 05 - 17 . Jump up ^ `` The League of Extraordinary Gentlemen '' . Chicago Sun - Times . Retrieved 2011 - 05 - 17 . Jump up ^ Vaughan , Owen ( February 25 , 2009 ) . `` Interview : Kevin O'Neill reveals the secrets of the League of Extraordinary Gentlemen and Marshal Law '' . Times Online . Times Newspapers Limited . They changed the whole balance by marginalising Mina and making her a vampire . ( registration required ) Jump up ^ Johnston , Rich ( May 23 , 2005 ) . `` Lying in the Gutters '' . Comic Book Resources . Retrieved January 7 , 2006 . ^ Jump up to : `` The League of Extraordinary Gentlemen -- Box Office Data , Movie News , Cast Information '' . The Numbers . Retrieved 2011 - 01 - 31 . Jump up ^ `` ( TB EXCLUSIVE ) Fox Enters Development on `` The League of Extraordinary Gentlemen '' Reboot -- The Tracking Board `` . The Tracking Board . Jump up ^ Goldberg , Matt ( August 13 , 2015 ) . `` ' League of Extraordinary Gentlemen ' Reboot to Be Female - Centric '' . Collider . External links ( edit ) Wikimedia Commons has media related to The League of Extraordinary Gentlemen ( film ) . The League of Extraordinary Gentlemen on IMDb The League of Extraordinary Gentlemen at Box Office Mojo The League of Extraordinary Gentlemen at Rotten Tomatoes The League of Extraordinary Gentlemen at Metacritic Article at FilmForce about the film `` Early review of the `` LXG '' script `` . Archived from the original on December 14 , 2000 . Stax 's review at IGN of a revised version of the script Internet Movie Firearms Database : Description of firearms used in The League of Extraordinary Gentlemen Zone Troopers : Website about the different Allan Quatermain and King Solomon 's Mine films Films directed by Stephen Norrington Death Machine ( 1994 ) Blade ( 1998 ) The Last Minute ( 2001 ) The League of Extraordinary Gentlemen ( 2003 ) The League of Extraordinary Gentlemen Alan Moore Kevin O'Neill Bill Oakley Jess Nevins Volumes and stories Volume I `` Allan and the Sundered Veil '' Volume II The New Traveller 's Almanac Black Dossier Volume III : Century Nemo Trilogy Adaptation Film Novel Soundtrack Main characters Wilhelmina Murray Captain Nemo Allan Quatermain Henry Jekyll / Edward Hyde Hawley Griffin Orlando History of the League World Links to related articles Live - action films based on DC Comics Serials Adventures of Captain Marvel Spy Smasher Batman Hop Harrigan The Vigilante Superman Congo Bill Batman and Robin Atom Man vs. Superman Blackhawk Single films Supergirl Steel Road to Perdition The League of Extraordinary Gentlemen Catwoman Constantine A History of Violence V for Vendetta Watchmen The Losers Jonah Hex Green Lantern Batman v Superman : Dawn of Justice Suicide Squad Wonder Woman Justice League Aquaman Shazam ! Franchises Batman 1960s Batman 1980s - 1990s Batman Batman Returns Batman Forever Batman & Robin 2000s - 2010s Batman Begins The Dark Knight The Dark Knight Rises Superman 1950s Superman and the Mole Men Stamp Day for Superman 1970s - 2000s Superman Superman II The Richard Donner Cut Superman III Superman IV : The Quest for Peace Superman Returns 2010s Man of Steel Red Red Red 2 Swamp Thing Swamp Thing The Return of Swamp Thing See also DC Films DC Extended Universe Robert Louis Stevenson 's Strange Case of Dr Jekyll and Mr Hyde Character Adaptations Films Dr. Jekyll and Mr. Hyde ( 1908 ) Dr. Jekyll and Mr. Hyde ( 1912 ) Dr. Jekyll and Mr. Hyde ( 1913 ) Dr. Jekyll and Mr. Hyde ( 1920 ) Dr. Jekyll and Mr. Hyde ( 1920 ) The Head of Janus ( 1920 ) Dr. Pyckle and Mr. Pryde ( 1925 ) Dr. Jekyll and Mr. Hyde ( 1931 ) Dr. Jekyll and Mr. Hyde ( 1941 ) The Son of Dr. Jekyll ( 1951 ) Abbott and Costello Meet Dr. Jekyll and Mr. Hyde ( 1953 ) Daughter of Dr. Jekyll ( 1957 ) The Doctor 's Horrible Experiment ( 1959 ) The Ugly Duckling ( 1959 ) My Friend , Dr. Jekyll ( 1960 ) The Two Faces of Dr. Jekyll ( 1960 ) The Nutty Professor ( 1963 ) Karutha Rathrikal ( 1967 ) Dr. Jekyll and Sister Hyde ( 1971 ) I , Monster ( 1971 ) Dr. Jekyll y el Hombre Lobo ( 1972 ) Dr. Black , Mr. Hyde ( 1976 ) Dr. Jekyll Likes Them Hot ( 1979 ) Dr. Heckyl and Mr. Hype ( 1980 ) Docteur Jekyll et les femmes ( 1981 ) Chehre Pe Chehra ( 1981 ) Jekyll and Hyde ... Together Again ( 1982 ) Edge of Sanity ( 1989 ) Dr. Jekyll and Ms. Hyde ( 1995 ) Mary Reilly ( 1996 ) The Nutty Professor ( 1996 ) The League of Extraordinary Gentlemen ( 2003 ) Van Helsing ( 2004 ) The Strange Case of Dr. Jekyll and Mr. Hyde ( 2006 ) The Mummy ( 2017 ) Animation The Impatient Patient ( 1942 ) Dr. Jekyll and Mr. Mouse ( 1947 ) Motor Mania ( 1950 ) Dr. Jerkyl 's Hide ( 1954 ) Hyde and Hare ( 1955 ) Hyde and Go Tweet ( 1960 ) Mad Monster Party ? ( 1967 ) Mad , Mad , Mad Monsters ( 1972 ) The Pagemaster ( 1994 ) The Strange Case of Dr. Jiggle and Mr. Sly ( 2004 ) Van Helsing : The London Assignment ( 2004 ) The Monster of Phineas - n - Ferbenstein ( 2008 ) Hotel Transylvania ( 2012 ) Video games Dr. Jekyll and Mr. Hyde ( 1988 ) Jekyll and Hyde ( 2001 ) Van Helsing ( 2004 ) Music `` Dr. Heckyll & Mr. Jive '' ( 1983 ) `` Bubba Hyde '' ( 1995 ) Jekyll and Hyde ( 2003 ) Jekyll & Hyde en Español ( 2004 ) Theatre Dr. Jekyll and Mr. Hyde ( 1887 ) Dr. Jekyll and Mr. Hyde ( 1888 ) Dr. Jekyll and Mr. Hyde , Or a Mis - Spent Life ( 1897 ) Jekyll & Hyde ( 1990 ) Television Julia Jekyll and Harriet Hyde ( 1995 -- 1998 ) Jekyll ( 2007 ) Once Upon a Time ( 2011 -- present ) Penny Dreadful ( 2014 -- 2016 ) Jekyll and Hyde ( 2015 ) Comics Mister Hyde ( introduced 1963 ) Batman : Two Faces ( 1998 ) The League of Extraordinary Gentlemen ( 1999 -- present ) Novels The Private Memoirs and Confessions of a Justified Sinner ( 1824 ) Knots and Crosses ( 1987 ) Mary Reilly ( 1990 ) Radio Dr. Jekyll and Mr. Hyde ( 1932 ) Bram Stoker 's Dracula Characters Original novel Count Dracula Abraham Van Helsing Jonathan Harker Mina Harker Lucy Westenra Arthur Holmwood Dr. John Seward Quincey Morris Renfield Brides Other works Adri Nital Alucard Count Alucard Count Orlok Count von Count Doctor Sun Eva Hamilton Slade Janus Postmortem Turac Historical Vlad Călugărul Vlad the Impaler Vlad II Dracul Films Universal series Dracula ( 1931 English - language ) Drácula ( 1931 Spanish - language ) Dracula 's Daughter ( 1936 ) Son of Dracula ( 1943 ) House of Frankenstein ( 1944 ) House of Dracula ( 1945 ) Abbott and Costello Meet Frankenstein ( 1948 ) Hammer series Dracula ( 1958 ) The Brides of Dracula ( 1960 ) Dracula : Prince of Darkness ( 1966 ) Dracula Has Risen from the Grave ( 1968 ) Taste the Blood of Dracula ( 1970 ) Scars of Dracula ( 1970 ) Dracula A.D. 1972 ( 1972 ) The Satanic Rites of Dracula ( 1973 ) The Legend of the 7 Golden Vampires ( 1974 ) Dracula 2000 Dracula 2000 ( 2000 ) Dracula II : Ascension ( 2003 ) Dracula III : Legacy ( 2005 ) Parodies Mad Monster Party ? ( 1967 ) Batman Fights Dracula ( 1967 ) Blacula ( 1972 ) Mad Mad Mad Monsters ( 1972 ) Blood for Dracula ( 1974 ) Vampira ( 1974 ) Son of Dracula ( 1974 ) Dracula in the Provinces ( 1975 ) Dracula and Son ( 1976 ) Love at First Bite ( 1979 ) The Halloween That Almost Was n't ( 1979 ) Fracchia contro Dracula ( 1985 ) The Monster Squad ( 1987 ) Scooby - Doo ! and the Reluctant Werewolf ( 1988 ) Dracula : Dead and Loving It ( 1995 ) Monster Mash ( 1995 ) Monster Mash ( 2000 ) Zora the Vampire ( 2000 ) Hotel Transylvania ( 2012 ) Hotel Transylvania 2 ( 2015 ) Monster Family ( 2017 ) Hotel Transylvania 3 ( 2018 ) Other Dracula 's Death ( 1921 ) Nosferatu ( 1922 ) The Return of the Vampire ( 1943 ) Drakula İstanbul'da ( 1953 ) Blood of Dracula ( 1957 ) The Return of Dracula ( 1958 ) Batman Dracula ( 1964 ) Billy the Kid Versus Dracula ( 1966 ) Dracula ( 1968 ) Blood of Dracula 's Castle ( 1969 ) Count Dracula ( 1970 ) Los Monstruos del Terror ( 1970 ) Cuadecuc , vampir ( 1971 ) Vampyros Lesbos ( 1971 ) Dracula vs. Frankenstein ( 1971 ) Bram Stoker 's Dracula ( 1973 ) Count Dracula 's Great Love ( 1974 ) Count Dracula ( 1977 ) Dracula 's Dog ( 1978 ) Doctor Dracula ( 1978 ) Nosferatu the Vampyre ( 1979 ) Dracula ( 1979 ) Nocturna : Granddaughter of Dracula ( 1979 ) Dracula 's Widow ( 1988 ) To Die For ( 1989 ) Sundown : The Vampire in Retreat ( 1989 ) Bram Stoker 's Dracula ( 1992 ) Nadja ( 1994 ) Shadow of the Vampire ( 2000 ) Dark Prince : The True Story of Dracula ( 2000 ) Dracula : Pages from a Virgin 's Diary ( 2002 ) Dracula ( 2002 ) The League of Extraordinary Gentlemen ( 2003 ) Van Helsing ( 2004 ) Van Helsing : The London Assignment ( 2004 ) Dracula 3000 ( 2004 ) The Vulture 's Eye ( 2004 ) Blade : Trinity ( 2004 ) The Batman vs. Dracula ( 2005 ) Bram Stoker 's Dracula 's Curse ( 2006 ) Dracula ( 2006 ) Bram Stoker 's Dracula 's Guest ( 2008 ) The Librarian : Curse of the Judas Chalice ( 2008 ) House of the Wolf Man ( 2009 ) Young Dracula ( 2011 ) Dracula Reborn ( 2012 ) Dracula 3D ( 2012 ) Saint Dracula 3D ( 2012 ) Dracula 2012 ( 2013 ) Dracula : The Dark Prince ( 2013 ) Dracula Untold ( 2014 ) Television Series Draculas ring ( 1978 ) Cliffhangers ( 1979 ) Drak Pack ( 1980 ) Count Duckula ( 1988 -- 1993 ) Dracula : The Series ( 1990 -- 1991 ) Little Dracula ( 1991 -- 1999 ) Ace Kilroy ( 2011 -- 2012 ) Young Dracula ( 2006 -- 2014 ) characters episodes Dracula ( 2013 -- 2014 ) Penny Dreadful ( 2014 -- 2016 ) Episodes `` Treehouse of Horror IV '' ( 1993 ) `` Treehouse of Horror XXI '' ( 2010 ) `` Buffy vs. Dracula '' ( 2000 ) Other novels The Dracula Tape and sequels ( 1975 -- 2002 ) Anno Dracula series ( 1992 -- present ) Anno Dracula The Bloody Red Baron Dracula Cha Cha Cha Dracula 's Guest and Other Weird Stories ( 1914 ) The Revenge of Dracula ( 1978 ) Little Dracula ( 1986 ) Dracula the Undead ( 1997 ) The Historian ( 2005 ) The Book of Renfield ( 2005 ) Bloodline ( 2005 ) Young Dracula and Young Monsters ( 2006 ) Fangland ( 2007 ) Dracula the Un-dead ( 2009 ) Radio Dracula ( 1938 ) Dracula ( 1975 ) Plays Dracula ( 1924 ) Dracula ( 1995 ) Dracula ( 1996 ) Musicals Dracula ( Czech musical ) ( 1995 ) Dracula : A Chamber Musical ( 1997 ) Dracula , the Musical ( 2004 ) Dracula -- Entre l'amour et la mort ( 2006 ) Dracula : the Musical ( 2010 ) Dracula -- L'amour plus fort que la mort ( 2011 ) Comics The Tomb of Dracula Dracula ( Marvel Comics ) Dracula ( Dell Comics ) Dracula Lives ! Hellsing The League of Extraordinary Gentlemen Sword of Dracula Batman & Dracula : Red Rain Victorian Undead Wolves at the Gate X-Men : Apocalypse vs. Dracula Purgatori Video games The Count ( 1981 ) Ghost Manor ( 1983 ) Castlevania series 1986 -- present Dracula Dracula ( 1986 ) Dracula the Undead ( 1991 ) Dracula Hakushaku ( 1992 ) Bram Stoker 's Dracula ( 1993 ) Bram Stoker 's Dracula ( handheld ) ( 1993 ) Dracula Unleashed ( 1993 ) Dracula : Resurrection ( 2000 ) Dracula 2 : The Last Sanctuary ( 2000 ) Van Helsing ( 2004 ) Dracula 3 : The Path of the Dragon ( 2008 ) Dracula : Origin ( 2008 ) Vampire Season Monster Defense ( 2012 ) Dracula 4 : The Shadow of the Dragon ( 2013 ) Dracula 5 : The Blood Legacy ( 2013 ) The Incredible Adventures of Van Helsing ( 2013 ) Drac 's Night Out ( unreleased ) Pinball Dracula ( 1979 ) Bram Stoker 's Dracula ( 1993 ) Monster Bash ( 1998 ) Other games The Fury of Dracula Castles Castle Dracula Bran Castle Poenari Castle Corvin Castle Albums Dracula Dracula 2000 Iubilaeum Anno Dracula 2001 Perfect Selection : Dracula Battle Transylvania Van Helsing Songs `` Love Song for a Vampire '' Audio dramas Son of the Dragon Related topics Dracula in popular culture Don Dracula Transylvanian Society of Dracula Dracula Society Dracula tourism Lugosi v. Universal Pictures `` Dracula / The Rose '' H. Rider Haggard 's King Solomon 's Mines Characters Allan Quatermain Sir Henry Curtis Sequels & prequels Allan Quatermain ( 1887 ) Maiwa 's Revenge ( 1888 ) Allan 's Wife ( 1889 ) Marie ( 1912 ) Child of Storm ( 1913 ) The Holy Flower ( 1915 ) The Ivory Child ( 1916 ) Finished ( 1917 ) The Ancient Allan ( 1920 ) She and Allan ( 1921 ) Allan and the Ice - gods ( 1927 ) Films King Solomon 's Mines ( 1937 ) King Solomon 's Mines ( 1950 ) Watusi ( 1959 sequel ) King Solomon 's Treasure ( 1979 ) King Solomon 's Mines ( 1985 ) Allan Quatermain and the Lost City of Gold ( 1986 ) King Solomon 's Mines ( 2004 ) Allan Quatermain and the Temple of Skulls ( 2008 ) Related The League of Extraordinary Gentlemen Oscar Wilde 's The Picture of Dorian Gray Films Dorian Grays Portræt ( 1910 ) The Picture of Dorian Gray ( 1913 ) The Picture of Dorian Gray ( 1915 ) The Picture of Dorian Gray ( 1916 ) The Picture of Dorian Gray ( 1917 ) The Picture of Dorian Gray ( 1918 ) The Picture of Dorian Gray ( 1945 ) Dorian Gray ( 1970 ) The Picture of Dorian Gray ( 1976 ) Dorian Gray ( 2009 ) Adaptations The Picture of Dorian Gray ( 1969 ) The League of Extraordinary Gentlemen ( 2003 ) Penny Dreadful ( 2014 - 2016 ) Literature The Happy Hypocrite Dorian , an Imitation A Portrait of Dorian Gray Stage Matthew Bourne 's Dorian Gray The Picture of Dorian Gray ( opera ) Inspirations John Gray `` The Oval Portrait '' Related Dorian Gray syndrome Adaptations `` Look Back in Anger '' Phantom of the Paradise VIAF : 225724698 LCCN : no2004002971 Retrieved from `` https://en.wikipedia.org/w/index.php?title=The_League_of_Extraordinary_Gentlemen_(film)&oldid=831188711 '' Categories : 2003 films English - language films The League of Extraordinary Gentlemen American films British films German films 2000s action films 2000s adventure films 2000s fantasy films 2000s superhero films Action adventure films American action films American alternate history films American fantasy adventure films American fantasy - comedy films American superhero films British action films British adventure films British fantasy films German action films German adventure films German fantasy films Crossover films Dr. Jekyll and Mr. Hyde films Films based on works by Alan Moore Films based on The Picture of Dorian Gray Films based on Wildstorm titles Films based on works by H. Rider Haggard Films based on works by Jules Verne Films based on works by Mark Twain Films directed by Stephen Norrington Films set in London Films set in Paris Films set in Venice Films set in Kenya Films set in Russia Films set in 1899 Films set in the Victorian era Films shot in the Czech Republic Films shot in Morocco Films based on The Invisible Man Live - action films based on comics Films involved in plagiarism controversies Steampunk films Science fiction submarine films Vampires in film Works based on Dracula Dieselpunk 20th Century Fox films Czech films Czech action films Czech adventure films Czech fantasy films Czech superhero films Films scored by Trevor Jones Hidden categories : CS1 maint : BOT : original - url status unknown Pages with login required references or sources Use mdy dates from October 2016 All articles with unsourced statements Articles with unsourced statements from December 2015 Wikipedia articles with VIAF identifiers Wikipedia articles with LCCN identifiers Talk Contents About Wikipedia Wikiquote বাংলা Български Čeština Dansk Deutsch Español Euskara فارسی Français Galego Հայերեն Bahasa Indonesia Italiano עברית Bahasa Melayu Nederlands 日本 語 ਪੰਜਾਬੀ Polski Português Română Русский Srpskohrvatski / српскохрватски Suomi Svenska 中文 17 more Edit links This page was last edited on 19 March 2018 , at 07 : 39 . 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Question: who played hyde in league of extraordinary gentlemen


Heart development - wikipedia Heart development Jump to : navigation , search This article is about a general overview of heart development . For protein signalling in heart development , see Protein signalling in heart development . Heart development Development of the human heart during the first eight weeks ( top ) , and the formation of the heart chambers ( bottom ) . In this figure , the blue and red colors represent blood inflow and outflow ( not venous and arterial blood ) . Initially , all venous blood flows from the tail / atria to the ventricles / head , a very different pattern from that of an adult . Anatomical terminology ( edit on Wikidata ) Heart development refers to the prenatal development of the human heart . This begins with the formation of two endocardial tubes which merge to form the tubular heart , also called the primitive heart tube , that loops and septates into the four chambers and paired arterial trunks that form the adult heart . The heart is the first functional organ in vertebrate embryos , and in the human , beats spontaneously by week 4 of development . The tubular heart quickly differentiates into the truncus arteriosus , bulbus cordis , primitive ventricle , primitive atrium , and the sinus venosus . The truncus arteriosus splits into the ascending aorta and pulmonary artery . The bulbus cordis forms part of the ventricles . The sinus venosus connects to the fetal circulation . The heart tube elongates on the right side , looping and becoming the first visual sign of left - right asymmetry of the body . Septa form within the atria and ventricles to separate the left and right sides of the heart . Contents ( hide ) 1 Early development 1.1 Endocardial tubes 1.2 Heart tube position 2 Heart folding 3 Heart chambers 3.1 Sinus venosus 3.2 Heart wall 3.3 Atria 3.4 Ventricles 3.5 Septum formation of the atrioventricular canal 3.6 Atrioventricular valves 4 Valves and outflow tracts 4.1 Truncus septum formation and arterial cone 5 Pacemaker and conduction system 6 References 7 Additional images 8 References Early development ( edit ) The heart derives from embryonic mesodermal germ - layer cells that differentiate after gastrulation into mesothelium , endothelium , and myocardium . Mesothelial pericardium forms the outer lining of the heart . The inner lining of the heart , lymphatic and blood vessels , develop from endothelium . Endocardial tubes ( edit ) In the splanchnopleuric mesenchyme on either side of the neural plate , a horseshoe - shaped area develops as the cardiogenic region . This has formed from cardiac myoblasts and blood islands as forerunners of blood cells and vessels . By day 19 , an endocardial tube begins to develop in each side of this region . These two tubes grow and by the third week have converged towards each other to merge , using programmed cell death to form a single tube , the tubular heart . From splanchnopleuric mesenchyme , the cardiogenic region develops cranially and laterally to the neural plate . In this area , two separate angiogenic cell clusters form on either side and coalesce to form the endocardial tubes . As embryonic folding continues , the two endocardial tubes are pushed into the thoracic cavity , where they begin to fuse together , and this is completed at about 22 days . At around 18 to 19 days after fertilisation , the heart begins to form . This early development is critical for subsequent embryonic and prenatal development . The heart is the first functional organ to develop and starts to beat and pump blood at around day 21 or 22 . The heart begins to develop near the head of the embryo in the cardiogenic area . Following cell signalling , two strands or cords begin to form in the cardiogenic region As these form , a lumen develops within them , at which point , they are referred to as endocardial tubes . At the same time that the tubes are forming other major heart components are also being formed . The two tubes migrate together and fuse to form a single primitive heart tube , the tubular heart which quickly forms five distinct regions . From head to tail , these are the truncus arteriosus , bulbus cordis , primitive ventricle , primitive atrium , and the sinus venosus . Initially , all venous blood flows into the sinus venosus , and contractions propel the blood from tail to head , or from the sinus venosus to the truncus arteriosus . The truncus arteriosus will divide to form the aorta and pulmonary artery ; the bulbus cordis will develop into the right ventricle ; the primitive ventricle will form the left ventricle ; the primitive atrium will become the front parts of the left and right atria and their appendages , and the sinus venous will develop into the posterior part of the right atrium , the sinoatrial node and the coronary sinus . Heart tube position ( edit ) The central part of cardiogenic area is in front of the oropharyngeal membrane and the neural plate . The growth of the brain and the cephalic folds push the oropharyngeal membrane forward , while the heart and the pericardial cavity move first to the cervical region and then into the chest . The curved portion of the horseshoe - shaped area expands to form the future ventricular infundibulum and the ventricular regions , as the heart tube continues to expand . The tube starts receiving venous drainage in its caudal pole and will pump blood out of the first aortic arch and into the dorsal aorta through its polar head . Initially the tube remains attached to the dorsal part of the pericardial cavity by a mesodermal tissue fold called the dorsal mesoderm . This mesoderm disappears to form the two pericardial sinuses the transverse and the oblique pericardial sinuses , which connect both sides of the pericardial cavity . The myocardium thickens and secretes a thick layer of rich extracellular matrix containing hyaluronic acid which separates the endothelium . Then mesothelial cells form the pericardium and migrate to form most of the epicardium . Then the heart tube is formed by the endocardium , which is the inner endothelial lining of the heart , and the myocardial muscle wall which is the epicardium that covers the outside of the tube . Heart folding ( edit ) The heart tube continues stretching and by day 23 , in a process called morphogenesis , cardiac looping begins . The cephalic portion curves in a frontal clockwise direction . The atrial portion starts moving in a cephalic ally and then moves to the left from its original position . This curved shape approaches the heart and finishes its growth on day 28 . The conduit forms the atrial and ventricular junctions which connect the common atrium and the common ventricle in the early embryo . The arterial bulb forms the trabecular portion of the right ventricle . A cone will form the infundibula blood of both ventricles . The arterial trunk and the roots will form the proximal portion of the aorta and the pulmonary artery . The junction between the ventricle and the arterial bulb will be called the primary intra-ventricular hole . The tube is divided into cardiac regions along its craniocaudal axis : the primitive ventricle , called primitive left ventricle , and the trabecular proximal arterial bulb , called the primitive right ventricle . Heart chambers ( edit ) Sinus venosus ( edit ) In the middle of the fourth week , the sinus receives venous blood from the poles of right and left sinus . Each pole receives blood from three major veins : the vitelline vein , the umbilical vein and the common cardinal vein . The sinus opening moves clockwise . This movement is caused mainly by the left to right shunt of blood , which occurs in the venous system during the fourth and fifth week of development . When the left common cardinal vein disappears in the tenth week , with only the oblique vein of the left atrium and the coronary sinus remaining . The right pole joins the right atrium to form the wall portion of the right atrium . The right and left venous valves fuse and form a peak known as the septum spurium . At the beginning , these valves are large but the left venous valve and the septum spurium fuse with the developing atrial septum . The upper right venous valve disappearing . The bottom evolves into : the inferior valve of the vena cava and the coronary sinus valve . Heart wall ( edit ) The main walls of the heart are formed between day 27 and 37 of the development of the early embryo . The growth consists of two tissue masses actively growing that approach one another until they merge and split light into two separate conduits . Tissue masses called endocardial cushions develop into atrioventricular and conotroncal regions . In these places , the cushions will help in the formation of auricular septum , ventricular conduits , atrio - ventricular valves and aortic and pulmonary channels . Atria ( edit ) Further information : Interatrial septum § Development The developing heart at day 30 . The septum primum ( top , middle ) develops downwards to separate the initially joined primitive atrium into left and right atria . At the end of the fourth week , a crest grows that leaves the cephalic part . This crest is the first part of the septum primum . The two ends of the septum extend into the interior of the endocardial cushions in the atrioventricular canal . The opening between the bottom edge of the septum primum and endocardial cushions is the ostium primum ( first opening ) . The extensions of the upper and lower endocardial pads grow along the margin of the septum primum and close the ostium primum . Coalescence of these perforations will form the ostium secundum ( second opening ) , which allows blood to flow freely from the right atrium to the left . When the right of the atrium expands due to the incorporation of the pole of the sinus , a new fold appears , called the septum secundum . At its right side it is fused with the left venous valve and the septum spurium . A free opening will then appear , called the foramen ovale . The remains of the upper septum primum , will become the valves of the foramen ovale . The passage between the two atrial chambers consists of a long oblique slit through which blood flows from the right atrium to the left . Ventricles ( edit ) Initially , a single pulmonary vein develops in the form of a bulge in the back wall of the left atrium . This vein will connect with the veins of the developing lung buds . As development proceeds the pulmonary vein and its branches are incorporated into the left atrium and they both form the smooth wall of the atrium . The embryonic left atrium remains as the trabecular left atrial appendage , and the embryonic right atrium remains as the right atrial appendage . Septum formation of the atrioventricular canal ( edit ) At the end of the fourth week , two atrioventricular endocardial cushions appear . Initially the atrioventricular canal gives access to the primitive left ventricle , and is separated from arterial bulb by the edge of the ventricular bulb . In the fifth week , the posterior end terminates in the center part of the upper endocardial cushion . Because of this , blood can access both the left primitive ventricle and the right primitive ventricle . As the anterior and posterior pads project inwardly , they merge to form a right and left atrioventricular orifice . Atrioventricular valves ( edit ) When forming intra-atrial septa , atrio - ventricular valves will begin to grow . An intra-muscular ventricular septum begins to grow from the common ventricle to the atrio - ventricular endocardial cushions . The division begins in the common ventricle where a furrow in the outer surface of the heart will appear the interventricular foramen eventually disappears . This closure is achieved by further growth muscular interventricular septum , a contribution of trunk crest - conal tissue and a membranous component . Valves and outflow tracts ( edit ) Truncus septum formation and arterial cone ( edit ) The arterial cone is closed by the infundibular cushions . The trunk cones are closed by the forming of an infundibulotroncal septum , which is made from a straight proximal portion and distal spiral portion . Then , the narrowest portion of the aorta is in the left and dorsal portion . The distal portion of the aorta is pushed forward to the right . The proximal pulmonary artery is right and ventral , and the distal portion of the pulmonary artery is in the left dorsal portion . Pacemaker and conduction system ( edit ) The rhythmic electrical depolarization waves that trigger myocardial contraction is myogenic , which means that they begin in the heart muscle spontaneously and are then responsible for transmitting signals from cell to cell . Myocytes that were obtained in the primitive heart tube , start beating as they connect together by their walls in a syncytium . Myocytes initiate rhythmic electrical activity , before the fusion of the endocardial tubes . The heartbeat begins in the region of the pacemaker which has a spontaneous depolarization time faster than the rest of myocardium . The primitive ventricle acts as initial pacemaker . But this pacemaker activity is actually made by a group of cells that derive from the sinoatrial right venous sinus . These cells form an ovoid sinoatrial node ( SAN ) , on the left venous valve . After the development of the SAN , the superior endocardial cushions begin to form a pacemaker as known as the atrioventricular node . With the development of the SAN , a band of specialized conducting cells start to form creating the bundle of His that sends a branch to the right ventricle and one to the left ventricle . Most conduction pathways originate from the cardiogenic mesoderm but the sinus node may be derived from the neural crest . The human embryonic heart begins beating approximately 21 days after fertilization , or five weeks after the last normal menstrual period ( LMP ) , which is the date normally used to date pregnancy in the medical community . The electrical depolarizations that trigger cardiac myocytes to contract arise spontaneously within the myocyte itself . The heartbeat is initiated in the pacemaker regions and spreads to the rest of the heart through a conduction pathway . Pacemaker cells develop in the primitive atrium and the sinus venosus to form the sinoatrial node and the atrioventricular node respectively . Conductive cells develop the bundle of His and carry the depolarization into the lower heart . Cardiac activity is visible beginning at approximately 5 weeks of pregnancy . The human heart begins beating at a rate near the mother 's , about 75 - 80 beats per minute ( BPM ) . The embryonic heart rate ( EHR ) then accelerates linearly for the first month of beating , peaking at 165 - 185 BPM during the early 7th week , ( early 9th week after the LMP ) . This acceleration is approximately 3.3 BPM per day , or about 10 BPM every three days , an increase of 100 BPM in the first month . After peaking at about 9.2 weeks after the LMP , it decelerates to about 150 BPM ( + / - 25 BPM ) during the 15th week after the LMP . After the 15th week the deceleration slows reaching an average rate of about 145 ( + / - 25 BPM ) BPM at term . References ( edit ) ^ Jump up to : Betts , J. Gordon ( 2013 ) . Anatomy & physiology . pp. 787 -- 846 . ISBN 1938168135 . Retrieved 11 August 2014 . Jump up ^ Moorman , A ; Webb , S ; Brown , NA ; Lamers , W ; Anderson , RH ( Jul 2003 ) . `` Development of the heart : ( 1 ) formation of the cardiac chambers and arterial trunks . '' . Heart ( British Cardiac Society ) . 89 ( 7 ) : 806 -- 14 . PMC 1767747 . PMID 12807866 . doi : 10.1136 / heart. 89.7. 806 . Jump up ^ Anderson , RH ; Webb , S ; Brown , NA ; Lamers , W ; Moorman , A ( Aug 2003 ) . `` Development of the heart : ( 2 ) Septation of the atriums and ventricles . '' . Heart ( British Cardiac Society ) . 89 ( 8 ) : 949 -- 58 . PMC 1767797 . PMID 12860885 . doi : 10.1136 / heart. 89.8. 949 . Jump up ^ `` Animal Tissues '' . Users.rcn.com. 2010 - 08 - 13 . Retrieved 2010 - 10 - 17 . ^ Jump up to : Sadler , T.W ( 2012 ) . Langman . Embriología Médica . Lippincott Williams & Wilkins . p. 165 . ISBN 978 - 84 - 96921 - 46 - 7 . Jump up ^ Larsen , William ( 2001 ) . Human Embryology ( 3rd ed . ) . Elsevier Saunders . p. 159 . ISBN 0 - 443 - 06583 - 7 . Jump up ^ `` Main Frame Heart Development '' . Meddean.luc.edu . Retrieved 2010 - 10 - 17 . Jump up ^ Larsen , William ( 2001 ) . Human Embryology ( 3rd ed . ) . Churchill Livingstone . p. 159 . ISBN 0 - 443 - 06583 - 7 . Jump up ^ Rohen , Johannes ; Lutjen , Elke ( 2008 ) . Embriología functional : una perspectiva desde la biología del desarrollo . Panamericana . p. 70 . ISBN 978 - 84 - 9835 - 155 - 2 . ^ Jump up to : Carlson , Bruce ( 2012 ) . Embriología humana y biología del desarrollo . Mosby . p. 451 . ISBN 84 - 8174 - 785 - 8 . ^ Jump up to : Fernández , Patricia Martha ( 2002 ) . Manual de biología del desarrollo . Manual Moderno . p. 243 . ISBN 968 - 426 - 976 - 5 . Jump up ^ Eynard , Aldo ; Valentich , Mirta ; Rovasio , Roberto ( 2011 ) . Histología y embriología del ser humano : bases celulares y moleculares . Panamericana . p. 283 . ISBN 978 - 950 - 06 - 0602 - 8 . Jump up ^ Moore , Keith L. ; Persaud , T.V.N ( 2008 ) . Embriología Clínica . Elsevier Saunders . p. 245 . ISBN 978 - 84 - 8086 - 337 - 7 . Jump up ^ Tellez de Peralta , Gabriel ( 2003 ) . Tratado de cirugía cardiovascular . Díaz de Santos . p. 44 . ^ Jump up to : Larsen , William ( 2003 ) . Embriología humana . Elsevier Science . p. 177 . ISBN 968 - 426 - 976 - 5 . Jump up ^ OBGYN.net `` Embryonic Heart Rates Compared in Assisted and Non-Assisted Pregnancies '' Additional images ( edit ) M - mode sonography measuring embryonic heart rate . Blood flow in a neonate Human embryo , 38 mm , 8 -- 9 weeks -- anterior view , heart is visible . References ( edit ) This article incorporates text from the CC - BY book : OpenStax College , Anatomy & Physiology . OpenStax CNX. 30 jul 2014 ... ( hide ) Development of the circulatory system Heart Tubular heart Truncus arteriosus Bulbus cordis Primitive ventricle Primitive atrium Sinus venosus Chamber formation Atrioventricular Primary interventricular foramen Endocardial cushions Septum intermedium Atrioventricular canal Atrial Septum primum Foramen secundum Primary interatrial foramen Septum secundum Foramen ovale Other Aorticopulmonary septum Protein signalling in heart development Vessels Arteries Dorsal aorta Aortic arches Aortic sac Veins Anterior cardinal vein Posterior cardinal vein Common cardinal veins Lymph vessels Lymph sacs Extraembryonic hemangiogenesis Blood islands Chorion Connecting stalk Yolk sac Placenta Fetal circulation umbilical cord : Umbilical vein → Ductus venosus → Inferior vena cava → Heart → Pulmonary artery → Ductus arteriosus → Aorta → Umbilical artery yolk sac : Vitelline veins Vitelline arteries Retrieved from `` https://en.wikipedia.org/w/index.php?title=Heart_development&oldid=805272989 '' Categories : Embryology of cardiovascular system Hidden categories : Articles which use infobox templates with no data rows Talk Contents About Wikipedia Español Edit links This page was last edited on 14 October 2017 , at 07 : 21 . 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Question: when does the heart develop and begin pumping blood

in the human, beats spontaneously by week 4 of development