Generated dataset of 25 benzothiazole derivatives were randomly divided into training set and test set 17 and 8 molecules respectively. Random distribution of training and test set will results into uniform distribution of biological activity across the molecules under study. Multiple linear regression analysis was utilized for development GQSAR models, with number of dependent variable limited to not more than 3 per model (Table 1).Table 1Table Showing Molecules under Study.Table 1Mole. NoRR1R2R3R4R51.HHHHHH2.HClHHHH3.HHHClHH4.HClHClHH5.HHCH3ClHH6.ClHHHHH7.ClClHHHH8.ClHHClHH9.ClClHClHH10.ClHCH3ClHH11.CH3HHHHH12.CH3ClHHHH13.CH3HHClHH14.CH3ClHClHH15.CH3HCH3ClHH16.OCH3HHHHH17.OCH3ClHHHH18.OCH3HHClHH19.OCH3ClHClHH20.OCH3HCH3ClHH21.NO2HHHHH22.NO2ClHHHH23.NO2HHClHH24.NO2ClHClHH25.NO2HCH3ClHH