The ubiquitin carboxy-terminal hydrolase L1 gene (Uchl1) has been shown to be closely related to brain function and neurodegenerative diseases. An antisense transcript of Uchl1, AS Uchl1, can regulate the expression of UCHL1 at the post-transcriptional level and enhance contact between post-transcriptional mRNA and polysaccharides, thus promoting the translation process and increasing protein synthesis. This activity has been disrupted in patients with familial PD, and studies have reported losses of UCHL1 activity in many other neurodegenerative diseases.48, 49 Regulation of Uchl1 expression can provide new ideas for PD treatment.