HIF-1 has been shown to regulate certain JmjC enzymes previously. As such, KDM3A, KDM4B, KDM4C, KDM5C, and KDM6B have all been shown to be HIF targets (reviewed in ). However, despite some reports indicating that KDM2A and KDM2B mRNA levels increase in response to hypoxia , there was no information as to whether these where HIF-dependent genes.