Arginine methylation has been known to be important in changing protein–protein interactions as well as in controlling subcellular localization of several proteins (Shen et al. 1998; Sinha et al. 2010). Furthermore, the expression of Hmt1 is cell cycle-dependent and the protein is active under different growth conditions in yeast (Messier et al. 2013), suggesting Sbp1 may play a role in the 5′UTR activation during cell cycle progression. Further investigations are needed to understand how the interactions between Sbp1 and Pab1, as well as the formation of a higher-order complex with eIF4G1 involved, are regulated by arginine methylation and the functional consequences of this regulation in translation of targeted mRNAs in the cell.