A 44-year-old male surgeon was presented to the neurology clinic with headache. After searching for possible causes of headache, pseudotumor cerebri was diagnosed. Mild anemia, decreased albumin, increased alkaline phosphatase and lactate dehydrogenase prompted to search for malignancy. Low platelet value together with anemia, decreased fibrinogen and increased D-dimer levels were consistent with microangiopathic hemolytic anemia and disseminated intravascular coagulation. Abdominal and pelvic CT revealed left adrenal mass, gastrohepatic lymphadenomegaly and a left iliac lytic lesion. FDG-PET/CT which was ordered for detection of primary site revealed moderately hypermetabolic lesion at the left upper abdomen suggestive of primary gastric tumor, in addition to widespread axial bone and bone marrow metastases, celiac, paraaortocaval and mesenteric lymphadenopaties with increased FDG enhancements. Upper endoscopic study proved gastric signet-ring cell carcinoma. A bone marrow trephine biopsy showed infiltration of the marrow with signet-ring cancer cells. He passed away without having chance for a chemotherapy challenge due to high level of bilirubinemia.