In the present comprehensive meta-analysis, we searched six databases to collect the evidence, containing three databases in English (PubMed, Web of Science and Embase) and three databases in Chinese (database of China National Knowledge Infrastructure (CNKI), VIP and WanFang). The terms for retrieval were: 1) “D dimer” or D-dimer or “D-dimer fibrin” or “D-dimer fragments” or “fibrin fragment D1 dimer”; 2) colorectal or colon or rectal or bowel; 3) cancer or carcinoma or adenocarcinoma or tumour or tumor or malignanc* or neoplas*. The literature retrieval of this current meta-analysis was updated to June 12, 2017.