Additional T. cruzi protein targets may be dihydrofolate reductase—thymidylate synthase (TcDHFR–TS), which showed an average docking energy with Copaifera diterpenoids of −93.2 kJ/mol, comparable to the docking energy of the normal substrate (dihydrofolate, −99.3 kJ/mol), as well as the TcDHFR–TS inhibitor cycloguanil (Edock = −83.1 kJ/mol); farnesyl diphosphate synthase (TcFPPS), with docking energies that averaged −96.2 kJ/mol, which is comparable to the docking energy of the normal substrate, isopentenyl diphosphate (Edock = −98.9 kJ/mol); and hypoxanthine phosphoribosyltransferase (TcHPRT), having an average Edock = −82.1 kJ/mol, compared to the normal substrate, hypoxanthine, with Edock of −65.9 kJ/mol.