We next tested if the number of previously established marginal effect SNPs (Pm<5×10−8) that were also nominally significant (Pv<0.05) for variance heterogeneity was greater than expected by chance (Tables 3 and 4, Fig 1). For 4 out of the 5 index traits, we observed enrichment at the lower end of the Pv distribution (Pv<0.05) for the established GWAS-derived lead SNPs. Thus, the nominally significant regions of the Pv distributions were generally enriched for GWAS-derived loci.