Angiogenesis is under the control of pro-angiogenic and anti-angiogenic factors . Tumor cells could produce and secrete such factors into surrounding environment to promote vessel growth. Endogenous activators and inhibitors are frequently targeted in tumor cells by miRNAs, which thereby regulate angiogenesis in a non-cell-autonomous manner (Table 1).Table 1MiRNAs involved in non-cell-autonomous regulation of tumor angiogenesis in tumor cellsTargetsmiRNAsExpression in tumor cellsRefVEGFmiR-20, miR-29b, miR-93, miR-126, miR-190, miR-195, miR-200, miR-203, miR-497, miR-503, miR-638, miR-27b, miR-128down[21–42]VEGF inducers HIF-1miR-22, miR-107, miR-519cdown[43–45] HIF-2miR-145down PI3K/AKT pathwaymiR-26a, miR-145down[47, 48] mTOR pathwaymiR-18a, miR-128, miR-145, miR-218down[49–52] IGF1R pathwaymiR-126, miR-181b, miR-148a, miR-152down[53–55]VEGF upstream TFs STAT3miR-874down Bmi-1miR-16down E2F3miR-34adown NF90miR-590-5pdownVEGF suppressor PTENmiR-21up E-cadherinmiR-9upVEGF independent factors FGFmiR-503down HDGFmiR-214, miR-497down[62, 63] angiogeninmiR-409-3pdown angiopoietinmiR-204down MMPsmiR-9, miR-26b-5p, miR-98, miR-181a-5pDown[66–69] TSP-1miR-17-92 cluster, miR-182, miR-194, miR-467up[75–78]IGF1R Insulin-like growth factor I receptor, Bmi-1 B-cell-specific Moloney murine leukemia virus integration site 1, E2F3 E2F transcription factor 3, NF90 Nuclear factor 90, TSP-1 thrombospondin-1, HDGF hepatoma-derived growth factor