Helicobacter pylori is a gram-negative, spiral shaped microaerophilic bacterium that colonizes the human gastric mucosa throughout life . Persistent H. pylori infection is associated with several gastrointestinal disorders, including chronic gastritis, peptic ulcer, lymphoid tissue lymphoma, and gastric adenocarcinoma . It has been reported that H. pylori may select a particular niche on the mucosa where the bacteria can evade host immune responses by utilizing delicate strategies to manipulate immune cells as well as protect against antibiotic attack, leading to the progression of gastrointestinal diseases [3, 4].