Cell-derived membrane vesicles (CMVs), including exosomes and microvesicles, are endogenous carriers transporting biological molecules to recipient cells. In contrast to established synthetic nanoparticles, CMVs are natural transporters and hence, less likely to exert toxicity or immune response, which probably due to their lowhoming to the liver [123, 124]. Moreover, CMVs are shown to contain ribonucleoprotein involved in cellular RNA transport as well as RISC components. Exosomes have already been utilized to transfer therapeutic RNAi to treat diseases [125, 126]. Therefore, CMVs hold great promise as a novel class of miRNA delivery system.