Inflammation is the biological response of tissues to infection with pathogens and cell damage . When harmful stimuli cause an inflammatory response, the body’s innate immune system involves the phagocytic activation of leukocytes and macrophages, and the increased release of inflammatory cytokines. Uncontrolled inflammation leads to disease progression because of the excessive production of inflammatory cytokines . DPB are a leading cause of inflammation in periodontal disease . Untreated gingivitis readily progresses to periodontitis and leads to tissue destruction. Bacterial plaque elaborate various compounds that elicit an inflammatory response and lead to destruction of the gingival tissue, which may progress to destruction of the periodontal ligaments. Plaque control is required to prevent further progression of inflammation. In this study, we tried to elucidate the critical factors involved in plaque bacteria-induced inflammation and effective natural anti-inflammatory substances for plaque bacteria control.