Based on the LAST alignment of the A. fumigatus proteome (9630 proteins) against S. cerevisiae, 474 unique proteins were recognized in A. fumigatus as the homologous of these proteins were not present in S. cerevisiae. All of the 474 proteins were further examined in KEGG, NCBI, EXPASY, and EBI databases. It was found that the functions of 161 proteins have already been explained, and their accession numbers are available. The remaining 313 proteins were found to be hypothetical (data not shown). Finally, 50 out of 161 protein candidates were chosen as they were fungal-specific but not present in S. cerevisiae (Table 2). The RBP, as a potential drug target, was selected for further evaluation. This protein is encoded by an 1158-bp gene located on chromosome 2 and has been annotated as a PPI.