Our study is a new integrating approach of accounting for multimorbidity patterns in studying HRQoL in healthy population. Indeed, available multimorbidity indices were based on specific outcomes, such as mortality, costs, or function, and therefore may not address a patient’s overall condition . In addition, they were validated on very specific populations and then it is difficult to apply them to other populations. The multimorbidity scores we identified (counted and weighted) can be used in clinical research to control for the effect of multimorbidity on patients’ HRQoL and may be useful for clinical practice.