In summary, this study shows that DMS induced cytoprotection against oxidative stress‐induced cell death and aging via an MsrA‐catalytic mechanism. A missing role of thiomethyl‐containing compounds, such as DMS, methyl mercaptan, and dimethyl disulfide, in the anti‐aging should been assigned in the mammals. With respect to analogues of DMS, its reaction priority and evolutionarily conservation suggest a similar function of DMS in humans.