One interesting family of JmjC enzymes that is deregulated in human disease  is KDM2. KDM2A and KDM2B demethylate histone 3 lysine 36 when mono- and dimethylated . The KDM2 family possesses additional functional domains to JmjC, including an Fbox domain, a PHD domain, a CXXC-zinc finger domain, and a leucine-rich repeat domain . Apart from demethylating histone H3 tails, these proteins have also been shown to have non-histone targets such as RelA and β-catenin . Furthermore, these enzymes have been shown to be deregulated in cancers such as breast and pancreatic .