Although no specific atopic personality profile has been established, growing knowledge of the nervous system supports new findings concerning the interaction between neuroimmunological and epigenetic factors. The skin and nervous system share a common origin: the ectoderm. Any factor that plays a neurological role can be observed in keratinocytes, fibroblasts, wandering or resident cells (mast cells, Langerhans cells), or stem or transient cells (lymphocytes, neutrophils and monocytes) of the skin. Thus, primitive defense responses such as inflammation and stress may modulate endocrine, dermatological and neurological responses [9, 10].