Two sets isotope-labelled mixed samples (set one is Ctr (114) and Cos (117); set two is Ctr (114), Dehy (115), CD (116) and VOSL (117)) were analyzed by Nano LC–Q/TOF MSE tandem mass spectrometry and identified a total of 430 proteins in set one (Supplementary Table S1), and 469 proteins in set two (Supplementary Table S2). Only protein quantification data with relative expression of >1.5 or <0.66 were chosen as differentially expressed proteins (Supplementary Table S3). The numbers of differentially expressed proteins in the Cos, Dehy, CD, and VOSL-treated group were 67, 59, 38, and 47, respectively. The differentially expressed proteins were imported into the IPA software for function annotation and interaction network analyses. The interaction networks of differentially expressed proteins in the Cos-treated group enriched 27 proteins (Supplementary Fig. S1A), thereinto, 15 proteins, which were APEX1, C1QBP, COL1A1, FAM162A, FXR1, HSPB8, HSPD1, LMNA, MAPT, NPM1, PGRMC1, RPS3, SET, SFN, STMN1, involved in the physiologic functions of cell death and survival. The interaction networks of differentially expressed proteins in the Dehy-treated group enriched 26 proteins (Supplementary Fig. S1B), of which there were 14 proteins, API5, BID, CFL1, EZR, FASN, GNB2L1, HMGB1, HSPB1, MAPT, SFN, SMARCB1, SON, TOP1 and YWHAZ, involved in the physiologic functions of cell death and survival. The interaction networks of differentially expressed proteins in the CD-treated group enriched 22 proteins (Supplementary Fig. S1C), among which there were 4 proteins, MAPT, CFL1, FLNB and SMARCA4, involved in the physiologic functions of cellular assembly, organization and cell cycle. The interaction networks in the VOSL-treated group enriched 23 differentially expressed proteins (Supplementary Fig. S1D), in which there were 11 proteins, API5, BID, GNB2L1, HSPB8, PARP1, RBM25, SFN, SND1, SON, TXN and UBR4, involved in the physiologic functions of cell death and survival.