The strengthening of some endogenous neuroprotective mechanisms as a mean by which to prevent and/or slow down the outcome of the various forms of neurodegenerative disorders has recently emerged as one of the most popular topics in applied neurobiology. It has been described that OECs exhibit the ability to promote regeneration in the damaged CNS, thus they could be involved as possible mediators of repair in neurological diseases 12, 14. As a source of different trophic factors, OECs have attracted an increasing interest as tool for regenerative medicine with applications that include spinal cord injury 55, 56 or axonal growth 57, 58 with a view towards new therapeutic approaches. It has been also demonstrated in vitro that the addition of OEC‐CM to the neuroblastoma SH‐SY5Y and SK‐N‐SH cells exposed to the neurotoxin 6‐hydroxydopamine (6‐OHDA) provides neuroprotective properties 59.