On the contrary, it has been demonstrated that γH2AX foci appear as band-like conformations  in deer mitotic cells, resembling perhaps the known bands in human mitotic chromosomes as seen in routine karyotype tests. Though, these conformations have not been detected in human mitotic cells, perhaps due to intrinsic features of human mitotic chromatin. Additionally, the possible detection of only one DSB in the nucleus by γH2AX immunocytochemistry  renders this technology as currently the most sensitive assay for the detection of DSBs.