14-3-3 proteins are a family of evolutionary conserved modulator proteins, which regulate multiple signaling pathways involved in mitogenesis, cell cycle progression, and apoptosis in cells through binding to specific Ser/Thr-phosphorylated motifs on target proteins39. It has been considered as an integration point which integrates a variety of apoptotic and survival signals to adjudicate cell survival or death38. Mammals express seven 14-3-3 isoforms which can form homo and hetero dimers. Upon target binding, 14-3-3 proteins can affect the function of target protein by modulating the enzymatic activity of target protein, its protein stability, cellular localization or its association with other proteins. AKT is a central mediator of the PI3K/AKT pathway, its activation was positively correlated with cancer development404142. Accumulating evidence showed that many AKT targets are also regulated by 14-3-3, including BAD43, TSC244, p27Kip145, YAP46, GSK347, PRAS4048, and LKB149. This sharing of targets is due to the overlap between the recognition motifs of AKT and 14-3-3: RxRxxS/T for AKT and RSxpS/TxP for 14-3-340.