Hematoxylin and eosin staining of gastrocnemius muscle sections confirmed preserved muscle integrity in P110‐treated SOD1 G93A mice. Measurement of individual muscle fiber diameter revealed a significant loss in SOD1 G93A mice as compared to WT mice (P = 0.00001), which was partially corrected in P110‐treated G93A mice, indicating decreased atrophy (P = 0.0003) (Fig 4B and E). Since previous studies have attributed muscle atrophy with increased oxidative stress, we determined 4‐hydroxy‐2‐nonenal (4‐HNE) adducts on proteins in gastrocnemius muscle (Russell et al, 2003; Colin et al, 2016). 4‐HNE is a nine‐carbon amphiphilic lipid‐derived aldehyde formed by oxidation of n−6 polyunsaturated fatty acids. It easily diffuses across biological membranes and irreversibly adducts to any macromolecules. Therefore, its level in tissues correlates with ROS production (Dalleau et al, 2013; Liou & Storz, 2015). SOD1 G93A mice showed increased 4‐HNE staining intensity (P = 0.00001), indicating increased oxidative stress that was significantly blunted with P110 treatment (P = 0.0029; Fig 4B and F).