Due to the fact that different subpopulations were included within CD45RA+ lymphocytes that may vary and influence the total results, we focused on one of the subpopulations – CD4+ naïve cells. (Fig. 4) In this subpopulation, the results were also statistically more significant when related to EDSS worsening. The percentage above 52.3% of total count of lymphocytes seemed to be important for protection against the clinical deterioration and the decrease of more than 30.5% as compared to the baseline value was a negative prognostic factor. No significant results were found in the context of the relapse.Fig. 41) ROC curves of naive helper cells CD45RA+ in CD4+ to predict CDP at one year. AUC for the population relative value = 0.662, AUC for the population relative value change compared to baseline = 0.628, AUC for the population relative value change compared to a measurement one year before = 0.523. 2) Survival curves and asymptotic log-rank tests for groups divided by the threshold