Controlling for age, education and household assets, there was no association between reproductive period and dementia incidence, either in individual sites or after pooled metaanalysis (ASHR per year 1.001, 95% CI 0.988–1.015, I2 0.0%) (Table 3). The effect of reproductive period was unchanged after controlling additionally for marital status, hazardous alcohol use, stroke, and height (ASHR per year 1.001, 95% CI 0.987–1.015, I2 0.0%). In Cuba, Dominican Republic, Venezuela and Puerto Rico, where APOE genotype was available, there was no evidence for an interaction between APOE genotype and reproductive period (ASHR 0.993, 95% CI 0.947–1.041, I2 = 39.3%), or for an effect of reproductive period among non-carriers of the e4 allele (ASHR 1.012, 95% CI 0.991–1.034, I2 = 0.0%). Controlling for APOE genotype in addition to age, education, household assets, marital status, hazardous alcohol use, stroke and height did not affect the fully adjusted association between reproductive period and incident dementia (ASHR 1.018, 95% CI 0.998–1.038, I2 = 0.0%).