We have also recently performed cross-linking/mass spectrometry on CMG-Mcm10 complex, and find that Mcm10 runs across the surface of two of the GINS subunits and the Cdc45 subunit, and wraps around 3 of the six Mcm2-7 subunits. The CX-MS results are not included here, because they are part of our study on the structure of CMG-Mcm10, but they confirm that GINS and Mcm10 are associated with CMG, and that Mcm10 binds a lot of the CMG subunits, which probably accounts for Steve Bell’s observation in his recent study that Mcm10 preferentially binds the complete CMG, and facilitates formation of the CMG complex (Lõoke, et al., 2017).