An effective substance is needed that will prevent and treat bacterial plaque-mediated disease by controlling bacterial growth and the inflammatory reaction. The fruits of the T. chebula, which has been amply verified as being medicinally valuable, has been used to treat cancer, cardiovascular diseases, paralysis, leprosy, ulcers, gout, arthritis, epilepsy, cough, fever, diarrhea, gastroenteritis, skin disorders, urinary tract infection, and wound infections [10, 24]. T. chebula fruit is also effective in the treatment of bacterial infections [25, 26]. Clinical trials of T. chebula fruit extract as a mouthwash preparation have reported reduced plaque accumulation and gingival inflammation [27, 28]. The present findings provide mechanistic details for these beneficial effects.