In addition to furthering the understanding of the relation between sensitivity to weak and reactivity to strong stimuli, our findings also have relevant implications for the study of temperamental and psychophysical determinants of noise annoyance or annoyance produced by other environmental nuisances in daily life. This regards, for example, the question whether noise sensitivity, a measure of discomfort in the auditory domain that predicts noise annoyance, is dependent on basic auditory perception or not (Ellermeier et al., 2001). As our results demonstrated, perceptual reward reactivity (HIP) may suppress the relation between auditory punishment reactivity (discomfort) and perceptual sensitivity. Therefore, in order to gain a more complete picture of the determinants of noise annoyance, we recommend including measures of reward reactivity to strong stimuli in future studies and controlling for it. In addition to noise annoyance, PARCS theory might also provide a framework to contribute to the understanding of other environmental intolerances, such as multiple chemical sensitivity (MCS). MCS, also known as idiopathic environmental intolerance (IEI), is a condition that is characterized by intolerance for chemical agents expressed as various somatic complaints including fatigue, headaches and pain (Graveling et al., 1999; Bornschein et al., 2002). Interestingly, MCS has been associated with anxiety and harm avoidance (Hillert et al., 2013) as well as with absorption (Witthöft et al., 2008) which are all indices of reactivity in PARCS theory.