Using non-compartmental methods, the pharmacokinetic parameters within plasma and dialysate temozolomide were determined by concentrations vs. time. While the maximum concentration (Cmax) and time maximum concentration (Tmax) were determined directly from the measured data points, half-lives (t1/2) were calculated from the elimination rate constant derived from the terminal slope. The AUC0–18 h for each day was estimated by standard non-compartmental analysis performed by Phoenix® WinNonlin version 6.3 (Pharsight Corporation, Mountain View, CA, USA). The pharmacokinetics variables were tabulated, using descriptive statistics calculated pre and post regadenoson. The differences of the AUCs were summarized by mean and standard deviation. Means and standard deviations were presented for peak drug concentration (Cmax), time of peak drug concentration (Tmax), drug half-life (t1/2) and area under the curve from time 0–18 h after temozolomide administration (AUC0–18 h).