Regarding the association between the schedule of WBRT and the HVLT-R score among the 29 patients who underwent both the four- and eight-month tests in the present study, neither the total dose nor the fractionation of WBRT affected the four- and eight-month HVLT-R scores. Wolfson et al. conducted the RTOG 0212 trial comparing three different prophylactic WBRT dose fractionations in LD-SCLC . They used the HVLT, the Controlled Oral Word Association Test (COWAT), and the Trail Making Test (TMT) parts A and B. Chronic neurotoxicity was defined as deterioration in at least one test without the development of brain metastases at 12 months. In a logistic regression analysis, chronic neurotoxicity was associated with the WBRT dose fractionation of 36 Gy in 18 fractions and older age. It seems difficult to assess the relationship between the WBRT dose fractionation and the incidence of 12-month decline in the NCF of BM patients, because the median survival time for all BM patients is approximately eight months . The late adverse effects of therapeutic WBRT for BM will be of clinical importance for long-term survivors.