This is a prospective study included 70 children presented with upper GIT bleeding indicated for upper gastrointestinal endoscopy admitted in pediatric department, Minia university hospital, Egypt during the period from February 2010 to December 2012. Thirty healthy children were included as a control group with age and sex matched. The study was approved by pediatric department council, Minia University and informed consents from parents or caretakers were taken. Children receiving any medications (NSAIDS, anticoagulants, corticosteroids) and those with known history of coagulopathy, bleeding disorders, diabetes mellitus or chronic illness were excluded from the study. All children after history taking and physical examination were exposed to laboratory investigations. Upper G.I.T endoscopy performed within 24 hours of admission for patients group only.