Percentages of naïve (CD45RA+) lymphocytes did not vary much (Table 1), but the statistical analysis revealed a significant relationship between this particular population and EDSS worsening. (Fig. 3) The probability of CDP was lower if the percentage of naïve lymphocytes was higher than 64.65% of total count of lymphocytes, and this was valid from the first year of follow-up. A more prominent decrease (to less than 95.9% of the baseline value) was a negative factor. However, the results were not significant when assessed with regard to the second relapse.Fig. 31) ROC curves of naive lymphocytes CD45RA+ to predict CDP at one year. AUC for the population relative value = 0.677, AUC for the population relative value change compared to baseline = 0.591, AUC for the population relative value change compared to a measurement one year before = 0.499. 2) Survival curves and asymptotic log-rank tests for groups divided by the threshold