The age of onset varies widely from childhood to over 90 years of age. Though most patients in clinical practice are middle-aged or older, juvenile onset is not rare. 38–45% of adult patients complain about first symptoms before the age of 20 (Walters et al., 1996; Montplaisir et al., 1997). A study in 2007 found rates of 1.9 and 2.0% in 8–11 years old and 12–17 years old children and adolescence, respectively. Another study using a different diagnostic criteria for RLS in children that published in 2003 revealed a prevalence of 5.9% (Kotagal and Silber, 2004). A newest pediatric RLS diagnostic criteria that include consideration of typical words used by children, differential diagnosis and comorbidity was published in 2013 (Picchietti et al., 2013). But no gender difference is found in pediatric RLS (Per et al., 2017). This gender difference in adult but not in children might be due to pregnancy because nulliparous women have about the same prevalence of RLS as males (Berger et al., 2004). The different classifications of RLS including primary and secondary RLS may also contribute to these findings. Sleep, mood, cognition, and quality of life are significantly affected in pediatric RLS patients (Picchietti and Picchietti, 2010). And ADHD, depressive symptoms, and anxiety are very common comorbidities of pediatric RLS patients (Pullen et al., 2011).