Many bacteria have been shown to associate with integrins (Hauck et al., 2012). Integrins can induce EGR1 expression through different signaling pathways (Lee et al., 2008; Cabodi et al., 2009). Here, we demonstrate for the first time that β1-integrins are often necessary for the bacterial induction of EGR1. Several bacteria have been shown to activate the EGFR, including N. menigitidis, N. gonorroeae, H. pylori, S. Typhimurium and P. aeruginosa. Often, this activation is indirect and mediated by bacterial induction of the cleavage of EGFR ligands by metalloproteases, allowing the ligands to bind to and activate EGFR (Keates et al., 2001; Zhang et al., 2004; Slanina et al., 2014). The importance of EGFR for EGR1 upregulation has been demonstrated in several studies (Meagawa et al., 2009; Voena et al., 2013). One study has shown the involvement of EGFR in the induction of EGR1 by a bacterial stimulus, H. pylori (Keates et al., 2005). Here, we confirm the importance of EGFR in EGR1 regulation and additionally demonstrate that EGFR is a common signaling molecule in bacteria-mediated EGR1 induction. Further, our data shows that ERK1/2 is another common signaling molecule in this process, but that EGR1 can also occasionally be induced by the JNK and PKA pathways.