Most patients in the study (87%) received two devices for delivery of fibrinolytic therapy and hence required more than one site of vascular access (Table 4). However, there was no difference in the number of devices used between those who developed major bleeding and those who did not. The majority of devices (238/278; 86%) were inserted via femoral venipuncture. Of these, 177 (74%) were inserted via the right femoral vein. All patients with major bleeding had femoral vein access for device delivery, compared to 84% in the group without major bleeding (p=0.04).