Although Copaifera diterpenoids showed only weak docking to parasite glyceraldehyde-3-phosphate dehydrogenases, they may still target these proteins. LmexGAPDH had an average Edock of −73.0 kJ/mol and TcGAPDH had an average Edock of −70.3 kJ/mol, but these docking energies are better than the docking energies of the normal substrate, glyceraldehyde-3-phosphate (Edock = −58.9 and −52.6 kJ/mol, respectively).