The present investigation has shown that the decoction comprised of N. sativa seeds, H. indicus roots, and S. glabra rhizomes can significantly protect against bleomycin induced (a) chromosomal aberrations, (b) formation of micronuclei, and (c) DNA dsbs in normal human peripheral blood lymphocytes. Decoction itself induces no significant chromosomal aberrations, no micronuclei formation, nor DNA dsbs in lymphocytes.