As the CBS mutation rate was also elevated in GS tumors (Fig. 4b), we investigated if there was a similar association between CBS mutations and SCNA in GS tumors. Although we found that mutated CBSs also tended to be closer to SCNA breakpoints compared to the non-mutated CBSs in GS tumors, the difference was not statistically significant (Supplementary Fig. 14), and the relative difference was greater in CIN (2.17-fold difference in distance to nearest breakpoint) compared to GS (1.58-fold difference) tumors. This may indicate that the coupling of CBS mutations and nearby chromosomal instability is a process that is specific to, or exacerbated in, the CIN tumors.