The effects of exercise frequency on uric acid differed by gender. In women, neither aerobic nor strength exercise participation were significantly associated with uric acid results. However, in men, reported days of both aerobic and strength exercise participation were significantly associated with lower uric acid. Lower uric acid may be an adaptation to training, as prior research has reported lower uric acid in male athletes compared to non-athletes . Uric acid increases after intense exercise that recruits fast-twitch muscle fibers , likely in order to increase serum antioxidant capacity and reduce oxidative stress during acute physical exercise . Despite its short term role in exercise responses, high resting uric acid has been associated with poor strength , vulnerability to tendon injury , and disease .