Once formed in the ER, CER is transported, by CER transfer protein CERT in mammals (Kumagai et al. 2005; Kudo et al. 2010; Rao et al. 2014), to the Golgi apparatus where the synthesis of complex SLs occurs (Ohanian & Ohanian, 2001; Bromley et al. 2003; Bartke & Hannun, 2009; Pata et al. 2010). ER CER concentration is kept under tight control as accumulation of CER here has been shown to result in induction of the mitochondrial apoptotic pathway (Vacaru et al. 2009; Tafesse et al. 2014) via an unknown mechanism (Bockelmann et al. 2015).