Diterpenoids isolated from Copaifera species have shown cytotoxic activities (Table 3). Copalic acid, isolated from C. langsdorffii, showed in vitro cytotoxicity on MO59J human glioblastoma cells and HeLa human cervical adenocarcinoma cells with IC50 of 68.3 and 44.0 μg/mL, respectively . Kaurenoic acid has demonstrated cytotoxicity against several human tumor cell lines, including CEM leukemia, MCF-7 breast tumor, HCT-8 colon tumor , AGP01 gastric tumor, and SF-295 glioblastoma . Growth inhibition of AGP01 and SF-295 cells was also demonstrated by 3β-alepterolic acid and 3β-alepterolic acid acetate . Methyl copalate showed remarkable cytotoxic activity on P-388 murine lymphoma (IC50 = 2.5 μg/mL), A-549 human lung carcinoma (IC50 = 5 μg/mL), HT-29 human colon carcinoma (IC50 = 5 μg/mL), and MEL-28 human melanoma (IC50 = 10 μg/mL) cells .