Oligonucleotides for siRNA were made by QIAGEN, using siRNA previously described Fis1 (Jofuku et al, 2005) and Drp1 (Taguchi et al, 2007). siRNA was transfected to healthy control and patient‐derived fibroblasts using Lipofectamine® RNAiMAX Transfection Reagent (Invitrogen) as using manufacture's protocols.