(A) LINP1 is induced by EGFR upon DNA damage and further stabilized by inactivation of miR-29 which is stimulated by p53. LINP1 can physically interact with Ku80-DNA-PKcs complex and promote DSB repair. (B) Short isoform of ASCC3 lncRNA is produced via alternative splicing after DNA damage and facilitates transcription recovery after DNA repair; while the long version of ASCC3 (protein coding transcript) inhibits transcription recovery.