BRAFV600E patients were selected to form the BRAFV600E group (n = 226), which excluded any other type of BRAF mutations. Wild Type group (n = 242) was formed by patients without any somatic mutation in BRAF gene, but patients with mutations in HRAS, NRAS, KRAS, EIF1AX, PPM1D, RET and NTRK1 were considered. It were selected only the patients with papillary thyroid cancer diagnosis.