Next to a negative association with the galactosylation of IgG-Fc-type N-glycans, we additionally report a positive association between (Δ)DAS28(3)-CRP and the sialylation of triantennary fucosylated glycans (A3FGS), notably of the α2,6-linked variety. This is in contrast to the TSNG changes throughout pregnancy, which shows marked increase of α2,3-linked sialylation but not an association with disease activity. A recent study, which compared total plasma N-glycosylation with the levels of various metabolic and inflammatory markers, has indicated a link between A3FGS and CRP, suggesting that the CRP component of DAS28(3)-CRP may in part be responsible for the association found within the current study (60). While the protein source of A3FGS remains unknown, future studies will have to reveal its biomarker potential and facilitate our understanding of RA disease severity.