The core AP algorithm is based on the regional optimization concept introduced by Cotrutz and Xing, (13) but is implemented based on the ROIs, (11) as opposed to the original voxel‐based approach. It attempts to iteratively fine‐tune the target coverage and OAR sparing results by creating multiple additional structures, based both on the relative geometry of originally segmented regions of interest (ROI) and on the transient dose distributions transpiring during the optimization process. As those ROIs are created, they are automatically assigned dose‐volume objectives and added to the standard optimization tab, thus becoming an additional input to the optimizer. Those additional objectives are added to help meet high and medium priority goals.