Upper gastrointestinal bleeding is a life threatening condition in children. Common sources of upper gastrointestinal bleeding in children include mucosal lesions and variceal hemorrhage [1, 2]. Incidence of upper GI bleeding was observed in 6.4-10% of pediatric ICU admissions [3, 4]. Helicobacter pylori (H. pylori) is a Gram negative spiral-shaped bacterium that is found in the gastric mucous layer or adherent to the epithelial lining of the stomach. H. pylori infection is related to more than 90% of duodenal ulcers and up to 70-80% of gastric ulcers . In adults, the presence of H. pylori confers a six fold increased risk of gastric adenocarcinoma, accounts for half of all gastric cancers and strongly implicated in the development of gastric B cell mucosa associated lymphoid tissue (MALT) lymphomas . Many studies investigated the relationship between H. pylori and upper GIT bleeding in adults , but no enough studies in children.