The discovery of extracellular vesicles (EVs) represents an exciting area of research that offers novel mechanisms for intercellular communication. EVs, generally including exosomes (typically 30–100 nm) and microparticles or microvesicles (typically 100 nm-1 μm), are small secretory vesicles that contain proteins, DNA, and coding and non-coding RNAs . EVs can be released from various cell types under physiological and pathological conditions and transfer their cargo to proximal or distal cells . In many published articles, the collective term “microvesicles” was used for all the EVs between 30 and 1000 nm in- diameter.