The effect of 0.2 ng l−1 O111:B4 LPS on the morphology of fibrin fibres in the platelet-poor plasma (PPP) of healthy individuals (with added thrombin). (a) Healthy fibres; (b,c) PPP with added LPS. (d) Fibre distribution of the control fibres and of controls with added LPS of 30 individuals. Note: in samples with added LPS, there were areas of matted layers with no visible fibres to measure. Fibres were measured using ImageJ as described in Material and methods.