The importance of miRNAs in ECs was demonstrated by the silencing of Dicer, an enzyme responsible for miRNA maturation. Knockdown of Dicer in ECs inhibited cell proliferation, migration and cord formation , indicating that miRNAs are important in the function of ECs. Many studies have shown that miRNAs in ECs regulate the cellular response to angiogenic factors by targeting surface receptors and signaling molecules (Table 2).Table 2MiRNAs involved in cell-autonomous regulation of tumor angiogenesis in ECsmiRNAsTargetsFunctionRefpro-angiogenesismiR-132p120RasGAPpromote ECs proliferation, tube formationmiR-130aGAX, HOXA5promote ECs proliferation, migration, tube formationmiR-146aBRCA1promote ECs proliferation, migration, tube formationanti-angiogenesismiR-128VEGFR-2inhibit ECs tube formationmiR-497VEGFR-2induce ECs apoptosismiR-296HGSinhibit ECs tube formationmiR-125bVE-cadherininhibit ECs tube formationmiR-34aE2F3, SIRT1, survivin, CDK4inhibit ECs proliferation, migration and tube formationmiR-126ADMinhibit ECs migration and tube formationHSG hepatocyte growth factor-regulated tyrosine kinase substrate, BRCA1 breast cancer 1, p120RasGAP Ras p21 protein activator 1, SIRT1 sirtuin 1, ADM adrenomedullin