The intuition gained from (i) is generalizable over a wide range of applications, while (ii) and (iii) are highly dependent on the MRI study design and the available hardware. Therefore, our challenge focuses on question (i), as an understanding of (i) is necessary to inform (ii) and (iii). To that end, we acquire the richest possible dataset using the most powerful hardware available and the most motivated subject available (UF). Specifically, we use the Connectome scanner,51 which is unique among human scanners in having 300 mT/m gradients, rather than 40 mT/m as is typical of state‐of‐the‐art human scanners. Preclinical work by Dyrby et al.13 highlights the benefits of such strong gradients and the first results from the Connectome scanner42, 52, 53, 54 are now starting to verify those findings.