The second list of genes (List2), consists of 154 unique genes (209 transcripts, Additional file 4) for which the contribution of the L/G ratio to the expression varied over time steps. Among these genes, 132 genes were further assembled into six functional networks that notably revealed hematological system development and function, tissue morphology, cancer, organismal injury and abnormalities, reproductive system disease, cellular growth and proliferation. The average evolution of all these genes shows the same expression profile. This group of genes is characterized by genes decreasing with a peak of expression at t=+1 and stable between t=+4 and t=+24. According to this analysis, it is unlikely that genes for which the contribution of the L/G ratio to the expression varied over time steps are directly involved in the immune response to LPS injection.