Experimental evidence (from our laboratory and others) has previously indicated the presence of CerS activity in Leishmania spp (Zhang et al., 2003; Denny et al., 2004, 2006) and in T. cruzi (De Lederkremer et al. 2011). More recently LAG1 orthologues have been identified and functionally and molecularly characterized in the latter parasite (Figueiredo et al. 2012). Other results indirectly suggest the presence of such activity in T. brucei (Patnaik et al. 1993; Richmond et al. 2010; Smith & Bütikofer, 2010). Similarly, CerS activity in the Apicomplexa has been inferred (Welti et al. 2007; Zhang et al. 2010; Pratt et al. 2013), but remains unexplored.