The 8 patients diagnosed with TB-HLH had no underlying diseases (Table 4). Overall, the disease had no specific clinical manifestations or symptoms, and the patients manifested a fever with no specific features, such as irregular fever and continued fever. Half of the patients (4 cases) presented with skin rash, which presented in different forms. The incidence rates of other positive symptoms including lymphadenectasis, splenomegaly, serous effusion, icterus, bleeding tendency, hepatomegaly, nervous system symptoms (including lethargy, delirium), and arthralgia were 87.5%, 75%, 75% (pericardial effusion 37.5%, pleurisy 25%, and ascites and pelvic fluid 12.5%), 50%, 50%, 37.5%, 37.5%, and 25%, respectively.