Our group has developed and evaluated in vitro two innovative formulations, a sodium-deoxycholate (Na-DOC) gel containing 0.05% w/w CP and CP loaded nanoparticles (NP), composed of lecithin and chitosan, dispersed in a chitosan gel. In particular, lecithin-chitosan nanoparticles have been previously proposed as a self-assembled nanometric delivery system for oral , topical  and nasal delivery .