Activation of UCP1 in BAT is a key factor in maintaining core body temperature especially when it is exposed to cold environment (Cannon and Nedergaard, 2004). Our study showed that during 6 h of exposure to cold, body temperatures of the untreated mice dropped significantly, displaying impaired thermogenesis compared with the drug treated-mice, which kept higher rectal temperature throughout the experiment, suggesting that supaglutide was able to increase body adaptation to cold exposure by generating more heat.