In the present study, the association between the GMV and IGD tendency was evaluated within the whole brain in adolescent online game players. After controlling for the effect of the total time of playing online game, the GMVs of the bilateral postCG, the left preCG, the left pMCC, and the right MFG were still negatively correlated to the IGD tendency. The adolescents with lower GMV in the brain regions related to sensorimotor process and cognitive control had higher IGD tendency.