Serology studies revealed that supaglutide treatment significantly decreased circulating levels of TC by 30% (Figure 5A, p < 0.001), and although not statistically significant, supaglutide also decreased circulating LDL levels by 21% (Figure 5A, p = 0.09). Moreover, supaglutide treatment decreased the TG level by 57% (Figure 5B, p < 0.001) and NEFA level by 68% (Figure 5C, p < 0.01) compared with control.