Finally, we studied the magnitude of IFNγ response to DENV NS1. Gideon's team did not observe differences in IFNγ induction between peptide pools and recombinant proteins in overnight ELISPOT assay using PBMC from the same donors 47. A higher magnitude of IFNγ response to DENV NS1 was found in experienced dengue donors, but a hyporesponsiveness was found in any acute viruses, even experiencing dengue. In 2001, our group described a reduced frequency of CD4+ and CD8+ T lymphocytes and a poor ability for T‐lymphocyte proliferation in response to mitogens and dengue antigens in acute DENV‐infected patients, but re‐established in convalescence phase 48. Another study found that in vitro exposure to DENV‐2 of T lymphocytes isolated from healthy donors reduces the lymphoproliferative capacity in response to mitogen, suggesting that DENV‐2 can inhibit T cell‐mediated immunity, bypassing monocytes and dendritic cells, classical DENV cell targets 49.