Lgr5 was identified as the putative marker of CSCs in colon cancers . Lgr5 was found to be related to depth of invasion, LNs metastasis, distance of metastasis and poor prognosis, and after Lgr5 was inhibited by siRNAs, fewer GC cells migrated through transwell model . Lgr5 had also been considered as an important marker in carcinogenesis of GC, indicating that Lgr5 expression was gradually increased from normal control tissues to GC tissues . Lgr5 was also been studied as a potential novel biomarker in chemoresistance of GC cells and predicting response to chemotherapy and prognosis . However, other study demonstrated that Lgr5 was increased expressed in well-moderate differentiation, stage I and stage II, compared with stage III and stage IV .