Supaglutide therapy improved metabolic conditions in HFD-induced obese mice was associated with significant reduction in TC, TG, NEFA, and a trend of decreased LDL. Elevation of these dyslipidemia-related circulating parameters are considered to be predictive of heart disease and atherosclerosis in obese and diabetic populations (Mokdad et al., 2003). Recent studies revealed beneficial effects of GLP-1 and its metabolites in cardiac dysfunction, reviewed in Li et al. (2017). Given its long-lasting GLP-1 actions and potential clinical compliance, it is of great interests to investigate whether supaglutide exerts cardioprotective effects in both preclinical and clinical settings.