C.B. designed and performed experiments, analyzed data, and wrote the manuscript; M.B., S.S., A.I.U.S., C.R., G.S., and F.S. performed experiments and analyzed data; E.P. analyzed data and revised the manuscript; C.R. collected clinical samples under ethical approval and revised the manuscript; G.D.A. collected clinical samples under ethical approval, revised the manuscript, and obtained funds for the research; C.E. designed the study and the experiments, wrote the manuscript, and obtained funds for the research. All authors approved the final manuscript.