Considering the immense potential benefits of omics based approaches in the field of oral pathology and cancer diagnosis in developing African regions, the authors make the following recommendations:Government focus should be directed at funding Infrastructure (bridging the record gap); funding researchers and supporting research training (bridging the knowledge gap).As custodians of various tissue specimens, pathologists must take the lead (and must not be passive) in the application of omics based molecular techniques to routine diagnostic services. Advanced certification and annual remedial courses are also recommended.With favorable health policy change, omics based molecular approaches should be integrated into routine clinical practice, taking dutiful quality assurance (internal and external) measures.There should be private sector/non-governmental organization (NGO) participation to make the task of integration of omics into oral pathology effective.Reimbursement policy for oral pathologist who are willing to practice omics science must be favorable.Legislative initiative must be available to pass this concept into law.Scarce resources must be maximized (using mobile phones, internet, etc. to improve the practice of omics based approaches in oral pathology),Viable collaborative team science established (sharing ideas, research, equipment and meetings) must be established locally, regionally, continentally and globally.Research and Educational Networks (RENs) must be established using a trans/inter/multidisciplinary approachOmics-based science and personalized medicine topics should be integrated into the undergraduate and postgraduate medical/dental training curriculumThere are many freely available online platforms that tremendously facilitate omics based techniques, such as the Gene Expression Ominbus (GEO) ; National Center for Biotechnology Information (NCBI) ; and The Cancer Genome Atlas (TCGA) . Such platforms offer great opportunities to develop knowledge in the omics field and researchers should be well enlightened about this.