The fungal kingdom encompasses diverse species, including a minority that have a devastating impact on human health. One of the most pervasive fungal pathogens of humans is Candida albicans 1, 2, which is a commensal on the skin and mucosal surfaces of up to 60% of healthy individuals3. As an opportunist, C. albicans can exploit a decline in host immunity or an imbalance in the host microbiome, leading to diverse pathologies such as oral thrush, vaginal candidiasis, or life-threatening bloodstream infections with mortality rates of ~40%4, 5. C. albicans thrives as a human pathogen in part due to its ability to evade host immunity by switching between yeast and filamentous morphologies, as well as due to its capacity to withstand the hostile host environment by activating robust stress responses6. The emerging paradigm is that C. albicans stress response pathways are not only critical for adaptation to host conditions, but they also enable fungal virulence and drug resistance7–11.