Within the limitations of this ex vivo study it can be concluded that the apical sealing ability of both MTA Fillapex and Adseal decreased when QMix was used as an irrigation solution. NaOCl followed by 17% EDTA yielded better results than QMix. In addition, Adseal showed better sealing ability than MTA Fillapex. So to conclude, none of the groups showed complete fluid-tight seal.