Multivariate analysis for LCSS for ESR population can be seen in Table 5. Age (p < 0.0001, HR = 1.023) and male sex (p < 0.0001, HR = 1.393) were significantly associated with LCSS. LCSS was not significantly associated with race or income. As compared to Connecticut, worse LCSS was noted in Greater Georgia, Kentucky, and Louisiana. Insured patients had a better LCSS than those on Medicaid (p < 0.0001, HR = 1.445). Married patients had a better LCSS than divorced (p < 0.0004, HR = 1.301) and widowed (p < 0.0036, HR = 1.200). Increasing tumor size (p < 0.0001, HR = 1.020) and T2 vs T1 (p = 0.0003, HR = 1.213) were associated with a worse LCCS. Only the right middle lobe location was associated with LCSS (p < 0.0469, HR = 0.803). As compared to patients with adenocarcinoma, NSCLC-NOS (p < 0.002, HR = 1.382) and large cell carcinoma (p = 0.0003, HR = 1.543) were correlated with a worse LCSS. Using well-differentiated tumors as a reference, all other tumor grades were associated with a worse LCSS (HR = 1.693–2.171). Segmentectomies (p < 0.0065, HR = 1.329), pneumonectomies (p = 0.0027, HR = 1.781), and wedge resections (p < 0.0001, HR = 1.353) were associated with a worse LCSS than (bi)lobectomies. Patients who received radiation (p < 0.0001, HR = 1.556) experienced worse LCSS. Number of nodes examined was associated with better LCSS (p < 0.0001, HR = 0.978). Compared to year 2007, those patients diagnosed in all other years, except for 2011 had a significantly better LCSS. OS and LCSS by marital status can be seen in Figures 3A,B.