When we compared SLC5A5 expression (retrieved from TCGA database) between PTCs harboring different mutations (BRAFV600E, TERTp and RAS) and WT PTCs, we observed that independently of the mutation, SLC5A5 expression was always significantly lower compared to WT PTCs. Moreover, we also observed that RAS mutation was the one with lower impact on SLC5A5 expression. PTCs with RAS mutation displayed significantly higher levels of SLC5A5 compared to BRAFV600E and BRAF + TERTp-mutated PTCs. In fact, it has been previously reported that a distinct profile of expression of genes involved in thyroid hormone biosynthesis (being SLC5A5 one of these genes) between BRAFV600E and RAS-driven PTCs, with RAS-like PTCs having relatively high thyroid differentiation score (30).