For the bioinformatics analyses, the processing settings were as follows: (1) detection scoring: miRNAs not detectable in all three samples or Ct ≥ 37 in at least two patients were not considered for future calculations; (2) the average of inter-plate calibrator (UniSp3 IPC) was calculated for each run (representing one sample), and the median was subtracted from each miRNA’s Ct; and (3) expression of each miRNA was derived using the 2−ΔΔCT method.41 On the basis of these criteria, array data were inspected using the NormFinder algorithm to assess the variance in expression levels.42 The best normalizer was found to be the average of assays detected in all three AVR samples; therefore this was used to normalize the array. Data are available at Gene Expression Omnibus (GEO: GSE80577).