A first question was whether the PC model was able to generate BPRs following activation of excitatory and inhibitory synapses (Cao et al., 2012; Herzfeld et al., 2015) and whether BPRs were different between Z+ and Z− PCs. The PC responses to input bursts generated by Granule cells (Rancz et al., 2007; van Beugen et al., 2013; Powell et al., 2015; Wilms and Häusser, 2015; Delvendahl and Hallermann, 2016) were tested in Z+ and Z− PC models in three stereotyped functional cases corresponding to the definitions of type I, type II and type III responses reported in vivo (De Zeeuw et al., 2011). Type I responses were driven by pure Granule cell excitatory inputs (100 synapses), type II responses were driven by both granule cell excitatory inputs (100 synapses) and SCs inhibitory inputs (25 synapses), type III responses were driven by SC inhibitory inputs only (25 synapses; Figure 2). In all cases, molecular layer interneuron inhibition was delayed by 4 ms to account for delays accumulated along the synaptic chain (Eccles et al., 1967; Ramakrishnan et al., 2016). In this set of simulations, a random distribution of active synapses was used and maintained the same with all the different stimulation patterns (Figure 2A).