9) Parts of the Discussion should be moderated. The limited resolution and a few static snapshots do not reveal all the details of membrane insertion and pore formation. Such details will come gradually from a host of biochemical and biophysical approaches. The suggestion that the CryoEM structure forms a good basis for drug discovery to treat numerous Gram-positive infections is not supported by any results in the manuscript so should be restricted to a speculative claim about S. pneumoniae.