These local drug release platforms face important challenges to ensure efficient therapy: (i) efficient loading of drugs, (ii) sustained delivery, (iii) avoiding the ‘burst effect’ (high dose release within the first minutes), (iv) material stability (avoiding degradation), and (v) the possibility to chemically modify their surface for a selective release . Many types of materials are currently used for the development of these new drug delivery platforms, such as polymers , hydrogels , iron oxide , graphene , porous silicon , and mesoporous silica . However, most of these existing carrier materials rapidly degrade at physiological pH or/and show poor drug loading with drugs mainly attaching to external surfaces and leading to an intense initial “burst” release.