Our research evaluated the expression of chemokine receptors on T cells. Chemokine receptors have been useful for dissecting T‐cell subsets with distinct migratory capacity and effector function 35. We assessed the effector as well as memory T cells by an increased expression of CCR5, CX3CR1, or CXCR3, in contrast to their T naïve precursors. CCR5 and CXCR3 are closely linked to Th1 function on activated CD4+, memory/activated CD8+ T cells, and NK cells 36, 37, 38. Our data confirmed an increased expression of CCR5 on T cells from acute dengue patients 39, 40. CCR5 expression would be promoting an enhanced T cell recruitment into the liver, a hypothesis that was corroborated by a high frequency of CCL5+ cells in hepatic tissue from dengue fatal cases 40. It is widely accepted that CCR5 is part of host's immune response in the dengue, its role, mediating the traffic of immune cells from blood to target tissues or acting directly on the antiviral response, is still unknown. A recent study demonstrated CX3CR1‐based transcriptome and proteome‐profiling defined a core signature of memory CD8+ T cells with cytotoxic effector function 41. Highly polarized CX3CR1+ cytotoxic CD4+ T cells was specifically expanded in exposed donors and, in particular, in those donors carrying an HLA allele associated with protection from severe dengue 42. By the fact that an increased frequency of CD4 and CD8 T cells expressing CX3CR1 in patients with DENV and, for the first time, in patients with ZIKV and DENV/ZIKV, our data could indicate a potential cytotoxic capacity of T cells from these in acute patients. The protective role of CXCR3 against DENV infection has been demonstrated in experimental models since CXCR3−/− mice infected by DENV presented a higher mortality rates than the wild‐type mice. Moreover, brains of CXCR3−/− mice showed higher viral loads and quantitatively fewer CD8+ T cells than those of wild‐type mice 43. We hypothesize that an increase in the frequency CD4+ and CD8+ T cells expressing chemokine receptors would contribute to regulate virus progression through a precise control of inflammatory cells targeting the affected tissue. Thus, chemokine receptors would play a more immunoprotective role once T cells could exert an antiviral, effector, cytotoxic, and migratory activities.