All three lots of RM 8671 were shown to be consistent with one another in terms of monomeric purity, thioether content, and glycan occupancy demonstrating good inter-lot homogeneity for these properties (ESM Table S8). Figure 5, for example, demonstrates that each material was observed to contain monomeric purity within ±3uc of one another. The current data suggest that the bulk homogenization method used to produce the RM 8671 lots was successful in producing highly consistent, reproducible lots, thereby ensuring long term consistency in product quality attributes.