Changes in daily food intake (Figure 2(a)) and body weight (Figure 2(b)) induced by intraperitoneal administration of saline over 4 days did not differ between mice treated with the PCPA (500 mg/kg) for 3 days and mice without PCPA treatment. Intraperitoneal administration of liraglutide (100 μg/kg) in mice significantly decreased food intake on the first day of treatment and decreased body weight over 4 days compared with saline controls in mice treated with or without PCPA for 3 days. Changes in daily food intake (Figure 2(c)) and body weight (Figure 2(d)) induced by intraperitoneal administration of liraglutide (100 μg/kg) over 4 days did not differ between mice treated with the PCPA (500 mg/kg) for 3 days and mice without PCPA treatment. These findings demonstrate that 5-HT is not required for feeding suppression and body weight loss induced by liraglutide in mice.