Information on commercial rabbit antibodies is as follows: EGFR (1902-1, 1:5000 for WB) and pEGFR (Tyr1068, 1727-1, 1:2500 for WB) were from Epitomics (Burlingame, CA, USA); ErbB2 (sc-284, 1:1000 for WB, 1:200 for immunofluorescence (IF)), ErbB3 (sc-285, 1:5000 for WB, 1:50 for IF), ErbB4 (sc-283, 1:5000 for WB) and pFAK (Tyr397, sc-11765-R, 1:200 for WB, 1:50 for IF) were from Santa Cruz (Dallas, TX, USA); ROCK2 (9029, 1:1000 for WB), Erk1/2 (9102, 1:5000 for WB), pErk1/2 (Thr202/Tyr204, 4370, 1:5000 for WB), Akt (9272, 1:5000 for WB), pAkt (Ser473, 9271, 1:3000 for WB) and pSTAT3 (Tyr705, 9145, 1:2000 for WB, 1:100 for IF) were from Cell Signaling (Danvers, MA, USA); Ki67 (RB-9043-P1, 1:500 for IF) was from Thermo (Fremont, CA, USA); Glyceraldehyde-3-phosphate dehydrogenase (ABS16, 1:2500 for WB), GFAP (AB5804, 1:2000 for IF) and Olig2 (AB9610, 1:500 for IF) were from Millipore (Temecula, CA, USA); pROCK2 (ab182648, 1:500 for WB), pSrc (Tyr418, ab4816, 1:1000 for WB, 1:100 for IF), Acsbg1 (ab65154, 1:500 for IF), pErbB3 (Tyr1328, ab133459, 1:2500 for WB, 1:100 for IF) and pErbB4 (Tyr1284, ab109273, 1:2500 for WB) were from Abcam (Cambridge, MA, USA); pProfilin (Tyr129, PP4751, 1:1000 for WB) was from ECM Biosciences (Versailles, KY, USA); AQP4 (HPA014784, 1:2500 for IF) and GS (G2781, 1:200 for IF) were from Sigma (St Louis, MO, USA). Information on commercial mouse antibodies is as follows: pErbB2 (Tyr1140, AP3781q, 1:2500 for WB) was from Abgent (San Diego, CA, USA); STAT3 (9139,1:1000 for WB, 1:1600 for IF)) was from Cell Signaling; MBP (MAB382, 1:1000 for WB), GFAP (MAB360, 1:3000 for WB, 1:2000 for IF) and Iba1 (MABN92, 1:1000 for IF) were from Millipore; Nestin (ab11306, 1:100 for IF) and Aldh1L1 (ab56777, 1:200 for IF) was from Abcam; RC2 (1:100 for IF) was from Developmental Studies Hybridoma Bank (Iowa city, IA, USA). Information on commercial goat antibodies is as follows: pFAK (Tyr861, sc-16663, 1:200 for WB, 1:50 for IF) and pFAK (Tyr925, sc-11766, 1:200 for WB, 1:50 for IF) were from Santa Cruz. Rat antibodies to CD45 (103101, 1:200 for IF) was from BioLegend (San Diego, CA, USA). Alexa Fluor 488- and Alexa Fluor 594-conjugated secondary antibodies (1:1000 for IF) were purchased from Invitrogen (Rockford, IL, USA), and horseradish peroxidase-conjugated secondary antibodies (1:5000 for WB) were from CWBIO (Beijing, China). Recombinant rat CNTF (cat. no. 557-NT-010/CF), rhEGF (cat. no. 236-EG-200) and recombinant human NRG1 (cat. no. 377-HB-050/CF) were from R&D (Minneapolis, MN, USA). Dox and TRIzol were from Sangon (Shanghai, China). Fluorescent mounting medium was from CWBIO. Protease inhibitor cocktail and bioinchoninic acid assay kit were from Thermo. EZ-ECL was from Biological Industries (Cromwell, CT, USA). PrimeScript Reverse Transcriptase was from Takara (Shiga, Japan). SYBR Green PCR mixture was from Bio-Rad (Hercules, CA, USA). All other chemicals were from Sigma.