DNA samples from 15 LTG-induced CADR patients (10 cases with MPE, 4 cases with SJS, and 1 case with DRESS) and 50 LTG-tolerant controls and the general population group were genotyped. The mean age of the LTG-induced CADR patients was 35.2 ± 22.1 and 73.3% were female. The median LTG dosage was 50 mg per day. There were no significant differences in gender, age, dosage of LTG, and concomitant use of valproic acid between the LTG-induced CADR patients and the LTG-tolerant patients (Table 1).