In the present study, we found the significant association between LTG-induced CADR and HLA-A∗02:07 and HLA-B∗15:02 when compared with both tolerant and general population controls. In addition, the HLA-A∗33:03 allele was present at a significantly higher rate in LTG-induced CADR patients than in the general population controls. These results suggest that HLA-B∗15:02, alone, might not be the only risk factor for LTG-induced CADR, but HLA-A∗02:07 and HLA-A∗33:03 may also be risk factors for LTG-induced CADR. The subgroup analysis revealed that the proportion of patients carrying the HLA-B∗15:02 allele was significantly higher in LTG-induced MPE cases than in both the tolerant control and general population groups, which is very different from previous studies in which HLA-B∗15:02 was not found to be associated with LTG-induced MPE (An et al., 2010; Shi et al., 2011). We demonstrated that HLA-A∗33:03 may be a risk factors for LTG-induced MPE, which again is different from the findings of a previous study in the Han Chinese population which found that patients carrying HLA-A∗33:03 had a lower risk for LTG-induced MPE (Li et al., 2013). The same study also found that patients carrying either of the HLA-A∗30:01 or HLA-B∗13:02 alleles had increased risk for LTG-induced MPE (Li et al., 2013). In this study, we did not find a significant association between HLA-A∗30:01 or HLA-B∗13:02 and LTG-induced MPE. One study found the HLA-A∗30:01 allele in 1 of 10 LTG-induced MPE patients, while HLA-B∗13:02 was absent in the same 10 LTG-induced MPE patients, which the authors suggested could be because of the low frequency of HLA-B∗13:02 (1.4%) in the Thai population (Puangpetch et al., 2015).