eQTL (expression quantitative trait loci) analysis. Expression of VPS13C (A–C), C2CD4A (D–F), and C2CD4B (G–I) was quantified relative to ACTB in 53 human donor islet samples and compared with the genotype at rs7163757. ΔCT is plotted against genotype for all samples (A, D, G; n = 53) or just samples from male (B, E, H; n = 13) or female (C, F, I; n = 40) donors, along with the mean and standard error. Since higher ΔCT corresponds to lower expression, possession of the risk allele (C) is significantly associated with lower VPS13C expression in samples from female donors (P = 0.041).