To date, in vitro selection experiments failed to select viruses with a high level of resistance to DTG, except when very high concentrations of DTG, until 500 nM, were used. Interestingly, no integrase resistance-associated mutations were detected in this resistant selected virus. However, this work of Malet et al. reported, for the first time, an INI-resistant virus with mutations selected outside integrase gene, located in the 3’ PPT region .