Here, in this study, the marine sponge Aurora globostellata is considered based on its importance in pharmaceutical applications (manuscript communicated). The compounds isolated have been characterized in detail for breast cancer. Their bioactivity is explored in in-vitro and in-vivo studies. The attempt has been undertaken to evaluate the mode of action and druggability of the metabolites isolated and characterized. The discovery of number of bioactive compounds from sponges has been increasing day by day. The natural source would overcome the existing synthetic drugs in mode of action and also reduce the side effects caused by the commercial compounds. Based on the 3D structure of the receptors, modern methods of discovering new leads from natural source are on the rise. The present study focuses on the in-silico analysis of the naturally isolated compounds from marine sponges and compared with the results for the commercial drugs: Afinitor, Halaven, Ixabipilone, Lapatinib, Letrozole, Palbocilib, Raloxifene, and Tamoxifen. The in-silico approach enables one to screen for ADMET properties of vast number of molecules within a few minutes thus reducing the time and is a non- expensive and non-tedious process with great accuracy, which is not possible in standard experimental methods [9, 10, 11]. A comparative analysis of the compounds using Glide Schrodinger package is used to find the common binding residues in HER2, the breast cancer target from among the ten considered compounds. This can confirm the quality of the natural compounds with high binding affinity than the commercial drugs [12, 13].