In conclusion, treatment with the EETC inhibits the growth of DPB as well as DPB-induced inflammation, and effectively abolishes DPB-LPS-induced osteoclastic bone resorption in vitro. EETC is an effective botanical chemopreventive agent that can modulate DPB-induced inflammatory factors involved in gingivitis and periodontal disease. EETC can be considered a promising anti-bacterial and anti-oral inflammatory agent capable of preventing the development of gingivitis and periodontitis. Further research is needed to isolate and identify the beneficial chemical constituents in the extract that could be exploited for pharmaceutical use.