Because most patients have varying degree of pain, redness, chemosis, lid edema, and anterior segment inflammation, recognizing endophthalmitis early is sometimes challenging. We found a different presentation of endophthalmitis after postvitrectomy compared to that after cataract surgery in terms of fibrin, corneal edema, and IOP, suggesting a differential response of eyes in these two conditions.[14–15] We found that a significant proportion of postvitrectomy endophthalmitis patients (73.4%) presented within 1 week of surgery, which is in accordance with the results of the previous studies. This implies that after vitrectomy, patients must be reviewed in the first week to allow early detection of this dreaded complication. With the presence of fibrin (present in 93.3% patients) and abnormal IOP (present in 55.6% patients, especially high IOP), clinician should suspect endophthalmitis as an important differential diagnosis. One additional finding in patients of postvitrectomy endophthalmitis was the presence of corneal ulcer and scleral necrosis in the area of sclerotomy. This indicates that meticulous examination of the sclerotomy site is important in the post-operative period.