Patients with upper extremity ALI are more likely to have atrial fibrillation (50%) as compared to the 29.8% of patients with lower extremity acute limb ischemia , while patients with lower extremity ALI had a higher percentage of aortic or mitral valvular disease or intracardiac thrombus . Upper extremity emboli are more frequent in women and patients with atrial fibrillation. Lower extremity emboli are more frequent in the presence of valvular disease or intracardiac thrombus and are associated with increased 30-day limb loss and mortality .