The study has several strengths. First, it is the largest case series of endophthalmitis after vitrectomy reported in literature; Second, being a single-center study, it scores over multicenter studies that are confounded by their inherent heterogeneous study design. Third, it addresses the concerns regarding the fear of increased endophthalmitis rate with MIVS using the largest database of 41,921 MIVS surgeries till date. Fourth, the differences between culture-positive and culture-negative cases have been shown in endophthalmitis after vitrectomy. And finally, the use of PCR, a modern sensitive tool used in our study, to exclude probable noninfectious cases has been appropriately demonstrated.