The filtering strategy described in the Methods Section and visualized in Fig. 2 resulted in 85 variants in 74 distinct genes in Fam1 and 242 variants in 212 distinct genes in Fam2. The gene sets for both families obtained by this filtering strategy are available as Additional file 1: Table S1. No CNVs in either family met the selection criteria. Since the number of genes per family was too large to analyze in detail, we decided to restrict our analysis to known ACM related genes and then to PKP2-related genes.