Cell death of human and rat FLS induced by BVCARHAdV5-PUMA. Cultures of human and rat FLS were non-treated a–c,g–i or treated d–f,j–l with proinflammatory cytokines, TNFα and IL-17. The FLS samples were mock-infected a,d,g,j, infected with BVCARHAdV5-GFP b,e,h,k or infected with BVCARHAdV5-PUMA c,f,i,l. Note the rounding-up of FLS after transduction with BVCARHAdV5-GFP in c,f,i,l. Scale bars, 20 μm