The present simulations allowed to investigate the foundations of PC responsiveness to synaptic bursts in a way that would not be possible with experiments only. Using the model, we could predetermine the composition of synaptic input patterns and analyze the neuron response mechanisms by independently monitoring several parameters (like membrane potential, ionic currents and calcium concentration) over multiple dendritic compartments. In response to pf and SC inputs, the PC model generated BPRs based on voltage-dependent activation of the dendritic Ca-KCa channel system. BPRs could reliably represent complex granular and molecular layer input patterns and depended on the specific sector of the dendritic tree that was stimulated, on the ionic channel complement, and on the excitatory/inhibitory synaptic pattern. These simulations suggest therefore that PCs exploit their intrinsic electroresponsiveness and the input pattern topography on the dendrites in order to generate a flexible BPR code (Herzfeld et al., 2015) to be relayed to DCN neurons.