Evidence is available on the role of Western-type diets (WD) in limiting cognitive abilities in critical brain maturation periods (i.e., infancy and childhood) . Animal models show that exposure to a high-fat, high-sugar (HFS) diet in adolescence is related to impairment in hippocampal learning and memory processes, regardless of weight status . One important mechanism that is proposed to underlie HFS-induced impaired hippocampal function is the reduced synthesis, secretion, and action of the brain-derived neurotrophic factor (BDNF). BDNF facilitates synaptic efficacy by converting changes in electrical activity to long-lasting changes in synaptic function, which is a suggested key process for memory formation . Reduced levels of BDNF in association with impaired memory function has been well documented in the literature .