BDNFOS is an antisense transcription product of brain-derived neurotrophic factor (BDNF), which upregulates the transcription of BDNF and the translation of BDNF-mRNA in HD. Small interfering RNA (siRNA) treatment with BDNFOS can induce Htt expression. BDNFOS has a protective effect on neurons and improves the HD phenotype,39 which is of some positive significance in the prevention and treatment of HD.