The model tracks the number of susceptible and infected cells in each of two spatial compartments, which can differ in size and in the effectiveness of antiretroviral therapy. Within each spatial compartment, infected cells can only transmit infection to other cells within the same spatial compartment, but a fraction of transmission is blocked by antiretroviral drugs. The model includes trafficking of cells between the two compartments, the rate of which can be changed using a trafficking therapy. The model also includes cell turnover.