A close relationship between allergic diseases and psychoneuroimmunoendocrinology exists [10, 30]. Stress negatively impacts patient quality of life, leading to development of depression, anxiety and unhealthy lifestyles along with secondary problems such as overweight and obesity, which negatively impact the control of atopic diseases . Studies support this association and urge further investigation. A study of adolescents in the United States documented that atopic diseases such as asthma, allergic rhinitis and atopic dermatitis correlate with increased risk of anxiety and depression and that this risk is further increased when asthma and allergic rhinitis are concomitantly present . Further research found that depressive disorders are common in individuals with asthma but that there is no correlation between the severity of asthma and the severity of depression . The quality of life of adolescent patients with atopic dermatitis and underlying psychiatric disorders was also assessed: a high prevalence of anxiety and depression was found in these individuals. Studies have shown a link between quality of life and sleep loss and depression induced by atopic dermatitis . Recently, the association between allergic rhinitis and psychiatric diseases such as depression and anxiety has been determined. In nine out of 11 studies, there was an association between allergic rhinitis and anxiety, and in ten out of 12 studies, there was an association of depressive disorder with allergic rhinitis . Patients with attention deficit/hyperactivity disorder have a higher incidence of asthma, allergic rhinitis and atopic dermatitis than the general population. Children with atopic diseases are exposed to higher levels of inflammatory cytokines that are released due to an allergic response, and these cytokines can cross the blood–brain barrier and activate neuroimmunological mechanisms involved in emotions and behavior. Furthermore, activation in regions of the prefrontal cortex, potentially due to exaggerated and sustained release of inflammatory mediators, has been found. Another possible hypothesis explaining the relationship between these two diseases is based on the finding that allergic rhinitis is often associated with sleep disturbance, which may cause symptoms of daytime fatigue, inattention, irritability and impulsivity, which are in turn components of clinical attention deficit/hyperactivity disorder and its associated pathologies . Urticaria occurs frequently in patients with psychiatric problems and emotional distress. Staubach P et al., found that 48 percent of patients with chronic spontaneous urticaria have at least one mental disorder; anxiety was the primary associated pathology, but depression and somatization disorders were also found [33, 36].