Between July 2011 and July 2012, a total of 39 eligible patients were enrolled from the Sun Yat-sen University Cancer Center. Clinical cutoff date was March 20, 2014. The median follow-up was 23.13 months. The baseline patient characteristics are summarized in Table 1. The median number of treatment cycles was 6 (range 1–20), with a total of 252. The median treatment period was 3.03 months (range 0.47–12.00). The median relative dose intensity was 91% for S-1 and 100% for LV.Table 1Baseline patient characteristicsCharacteristicsS-1 plus LV (N = 39)No.%Gender (male/female)28/1171.8/28.2Age (years, median, range)55 (21–83)Body surface area (m2, median, range)1.51 (1.33–1.94)ECOG performance status = 139100Primary tumor location Proximal1128.2 Body717.9 Antrum1025.6 Multiple/diffuse1128.2Histology Well differentiated37.7 Moderately differentiated717.9 Poorly differentiated2461.5 Mucinous410.3 Signet-ring cell12.6Lauren classification Diffuse type411.1 Intestinal type1333.3 Mixed type2255.6Her-2 gene type Positive615.4 Negative3384.6Site of metastases Liver1435.9 Lung37.7 Lymph nodes2974.4 Peritoneum1435.9 Bone410.3No. of metastatic/recurrent sites 11846.2 21641.0 3512.8Prior surgery Curative gastrectomy820.5 Palliative gastrectomy/metastectomy512.9 Exploration/bypass410.3 No2256.4Prior adjuvant chemotherapy Yes615.4 No3384.6