We performed a genome-wide search for SNPs whose associations with the following traits are characterized by high between-genotype variance heterogeneity: BMI, TC, TG, HDL-C and LDL-C. The variance heterogeneity analyses were performed using Levene’s test  in up to 44,211 participants of European descent from seven population-based cohorts. Descriptions of these cohorts are presented in S2 Table. To minimize bias that might result from unequal sample sizes between SNPs when calculating the correlations between the P-values from the marginal (Pm) and variance heterogeneity (Pv) meta-analyses, we restricted the sample size for analyses to 26,000 participants for BMI and to 24,000 participants for lipid traits (S4 Fig).