Gap junctions, as well as HCs, play a crucial role in a wide range of cellular activities, including cell signalling, differentiation, growth, pro‐apoptotic signalling, either as anti‐apoptotic gates or pathogenic pores depending on conditions and cell type 29, 30, 31, 32. Gap junctions and free HCs are extensively distributed in different tissues and organs 33 in which different cell type usually expresses specific Cxs profile involved in the selective permeability of channels formed, according to the metabolic or functional needs 34, 35, 36, 37, 38. Also in the CNS, GJs and HCs are extensively distributed among neurons and glial cells 39, 40, 41, where, contributing to GJIC and cell‐extracellular communication, they provide specific exchange pathways under resting conditions, and also play a context‐dependent role in contradictory cell survival or cell death phenomena 42.