The effects of exercise participation on blood globulin proteins showed a more consistent effect, where more days of either aerobic exercise were associated with lower levels of globulin protein in the blood for both men and women. Similarly, globulin levels have been shown previously to decrease with endurance exercise . As globulin proteins consist of a variety of proteins, it is plausible that reduced globulins with exercise participation is a physiological adaptation to increase the bioavailability of different compounds in the body  as opposed to a reduction in immunoglobulins .