Plants have developed two major strategies to counteract virus infections: resistance (R) gene-mediated, and RNA silencing-based defenses. In addition, the mutation in essential genes for viral infection also causes plant resistance against viruses, called recessive gene-mediated resistance. These approaches have been used in crop protections and have shown significant economic impact (Abel et al., 1986; Whitham et al., 1996; Baulcombe, 2004; Kang et al., 2005; Wang and Krishnaswamy, 2012).