One study found that LTG-induced CADR in the Japanese population was associated with HLA class II alleles, including HLA-DRB1∗04:05, HLA-DQB1∗04:01, and HLA-DQA1∗03:03 (Ito et al., 2015), but HLA class II genotyping was not performed in this current study. However, it would be interesting to investigate the association of HLA class II and LTG-induced CADR in each population and with a large number of patients to better understand any association. Nevertheless, previous studies identified age and concomitant use of LTG and valproic acid as risk factors for LTG-induced CADR (Cheung et al., 2013; Egunsola et al., 2015). However, in our study we did not find that age and concomitant therapy with valproic acid were risk factors for LTG-induced CADR.