PCP signaling has been suggested to be primarily required for cytoskeletal activity, for example, cellular protrusion, cell-cell adhesion, and cell-matrix adhesion . Skin development, body hair orientation, polarization of the sensory epithelium in the inner ear, and the directed movement of mesenchymal cell populations during gastrulation are among the processes requiring proper PCP signaling in vertebrates [227, 254–256]. In vertebrates, function of the PCP pathway appears to be required for convergent extension (CE). Lamellipodia have been the type of cell shown to drive CE. These broad sheet-like protrusions exert traction on adjacent mesodermal cells causing mediolateral intercalation [257–259]. PCP signaling causes the regulation of cytoskeletal organization that redistributes subcellular PCP components asymmetrically causing polarization of these cells . Moreover, components of the signaling cascade converge or are expressed asymmetrically in the lamellipodia [250, 253].