Likewise, 157 of 257 (61.08%) exhibited telomere signal diminution in CAFs compared with paired NTFs (p < 0.001; Figure 3B and supplementary material, Figure S2B). Diffuse or aggregated infiltration of lymphocytes was found in peritumor areas and tumor margins, with less abundant lymphocytes in intratumor areas (supplementary material, Figure S2C). Nevertheless, no obvious differences were found in telomere lengths in TILs and PTILs (p = 0.587; Figure 3C). Intrahepatic bile ducts were detected in intratumor areas of only 92 cases, but in the peritumor area of 168 cases (supplementary material, Figure S2D). Differences in telomere length were hard to find in BDECs between paired intratumor and peritumor areas (data not shown). The telomere length in tumor cells, CAFs, and TILs had a wide dynamic IQR.