TEG analysis of WB (10 min incubation time with O111:B4 LPS) showed that the R, TMRTG and TTG are all significantly decreased (table 1). Changes to R indicate that the clot forms quicker and a decreased TMRTG indicates that the time to maximum thrombus generation is also faster, suggesting a hypercoagulable state. The TTG is also significantly decreased suggesting total thrombus generation, thus implying clot strength is decreased, although the clot forms faster. The SEM fibrin fibre thickness results show areas where no individual fibres are formed; instead, a matted homogeneous layer forms, and there are also areas of fine and short fibres. Here, we suggest that this morphology is probably related to the decreased TTG, where the fibrin structure results in a clot with decreased strength. We have not measured lyses, but a decreased TTG is likely to indicate a hypofibrinolytic nature of the clot. We have previously shown that the same concentration of LPS as used in this paper, when added to naive uncitrated healthy blood but without added CaCl2, also had an effect on coagulation after only 30 s incubation time . Both TMRTG and R of naive WB were also significantly shorter, also showing hypercoagulation, and the TTG was increased, but not significantly increased. However, in this study, the blood was not drawn in citrated tubes and therefore not re-calcified.