Carel et al. (2009) emphasized the need for investigation of the potential psychological effects associated with peripubertal GnRHa-treatment in CPP. Similarly, the potential effects of GnRHa-treatment on cognition during this important developmental period are not well characterized. Wojniusz et al. (2016) recently demonstrated that peripubertal GnRHa increases emotional reactivity (i.e. emotional and behavioral responses to a fearful situation) in girls with CPP, whereas resting heart rate decreased and this effect was more pronounced with longer durations of GnRHa-treatment. Studies, using an ovine model, have also demonstrated that peripubertal GnRHa-treated rams display increased risk-taking behavior (Wojniusz et al., 2011), altered emotional reactivity (Evans et al., 2012) and reduced long-term spatial reference memory (Hough et al., 2016). Physiological changes within the limbic system have also been reported in this ovine model, as peripubertal GnRHa-treatment alters amygdala volume (Nuruddin et al., 2013a) and the expression of hippocampal genes that are involved in endocrine signaling and synaptic plasticity (Nuruddin et al., 2013b). With this growing body of evidence that peripubertal GnRHa-treatment may affect development of cognitive function, there is now a requirement to investigate whether these effects are reversible when GnRHa-treatment is discontinued.