Based on Wolff’s law, the bone cell tends to proliferate by the compressive stimulation because bone composition has piezoelectric properties and bone remodeling is caused by various stimulations . In addition, Compressive stimulation can lead to osteogenic gene expression for proliferation and differentiation [9, 10]. It would depends on the Poisson’s ratio in order to determine the compressive stimulation acted on the bone cells in 3-D scaffolds. The conventional 3-D scaffolds or matrices including all common materials have a positive Poisson’s ratio .