It is well known that the PI3K/Akt/mTOR pathway is important and has been successfully targeted in many cancers, including many lymphomas (Westin, 2014). GSN-PI3K-Akt signaling could be involved in regulating the EMT transcription factors (Westin, 2014). GSN has been shown to physically associate with PI3K (Chellaiah et al., 2000) and promote its activity (Singh et al., 1996). An earlier study showed that inhibition of PI3K repressed GSN protein expression and decreased migration and invasion of hepatocarcinoma cells, which suggested that GSN is involved in the PI3K-Akt pathway (Wu et al., 2013).