NEAT1 (nuclear paraspeckle assembly transcript 1) is a nuclear-enriched ncRNA essential for the formation and maintenance of paraspeckles, which are subnuclear bodies found in mammalian cells.40 Sunwoo et al.4 found that NEAT1 levels increased in R6/2 mice and HD patients. To determine the biological effects of NEAT1 on neuronal survival, they transfected neuro2A cells with NEAT1 short isoform vector and subjected them to H2O2-induced damage. The NEAT1-transfected cells showed increased viability under oxidative stress, confirming that NEAT1 upregulation contributes to neuroprotective mechanisms against neuronal damage, rather than to the pathology of neurodegenerative diseases.