Bitterness is often perceived as an unpleasant taste, albeit it is considered desirable in some products such as tea, coffee, and beer etc. In most cases, bitterness influences the palatability of the functional beverage and food containing the bitter ingredients, and also poses a major problem for the patient acceptability and compliance of the bitter-taste drugs, especially for the pediatric formulations (Drewnowski and Gomez-Carneros, 2000; Mennella et al., 2013). Therefore, the bitter-tasting assessment is imperative in the functional food/beverage development, and could be considered in advance during the drug discovery process.