According to our analysis by age groups and gender, decrease in HRQoL was associated more with the DUKE than the SF-36, especially for pattern A score. This result was expected, considering that the Duke Health Profile has more items oriented toward mental health than the SF-36, which is a more general questionnaire. Several studies have shown that among all morbidities, mental disorders have the highest impact on HRQoL . Nevertheless, other studies did not account for these conditions in HRQoL assessment . Our results highlight the importance of considering mental disorders in HRQoL studies.