Many interviewees emphasized the key role of the institutional Research Ethics Board (REB) in facilitating their open science practice. One third of interviewees suggested that the REB is sometimes overly stringent and acts as a barrier to efficient sharing of their own research data, or to making use of patient data shared through open web repositories. Conversely, just under two thirds of interviewees said that the REB is evolving in step with open approaches to science, for example partnering with researchers to develop detailed governance mechanisms and patient consent protocols to allow broad sharing (Das et al., 2016; Poupon et al., 2017). Some interviewees underlined that harmonizing ethical requirements across Canada and internationally is a key priority to realize the promise of global open science. One way that harmonization could accelerate open science would be the introduction of standard click-wrap agreements that are signed when patient-derived data are downloaded, thus avoiding the need use traditional (and cumbersome) side agreements that are signed (and sometimes notarized) by central administrators (NKI-RS, 2017).