In the present investigation, the effect of the decoction was evaluated at a single preincubation period of 3 hrs. However, the in-cooperation of different preincubation periods may have a significant impact on the claimed radioprotective potential of the decoction under current investigation. Despite these limitations, the findings of the present study clearly indicate the broad functional spectrum of the decoction comprised of N. sativa seeds, H. indicus roots, and S. glabra rhizomes in cancer management.