Limited studies have looked at the long-term effects of GnRHa-treatment on cognition in children and adolescents. One study reported that 3-year GnRHa-treatment of girls with early pubertal onset was associated with a 7% reduction in IQ (Mul et al., 2001). This effect was hypothesized to be attributed to the suppression of sex steroids and their effect on brain development which resulted in a more age-appropriate IQ (Mul et al., 2001). A recent study of girls treated with GnRHa for CPP, reported that they exhibited increased emotional reactivity and a decreased resting heart rate (Wojniusz et al., 2016). Interestingly, the changes in heart rate observed in that study were dependent upon the duration of GnRHa-treatment. Taken with the results of this study – in which it is indicated that peripubertal GnRHa-treatment affects aspects of cognitive function – it may be worth considering the duration of the GnRHa-treatment in children and adolescents, and limiting it where possible (Hayes, 2016).