Aβ is a normal metabolite generated by the hydrolysis of β-amyloid precursor protein (APP). β-site APP cleaving enzyme 1 (BACE1), a membrane-bound aspartic protease, is involved in the processing of APP and cleaves it to Aβ. BACE1-AS (BACE1-antisense) is an antisense transcript of BACE1. The expression of BACE1-AS in the brain of AD patients is upregulated, suggesting that BACE1-AS may play a role in the pathogenesis of AD.21, 22 Studies have shown that BACE1-AS can bind to BACE1 mRNA, increase the stability of the latter, thereby promoting the synthesis of BACE1 protein,21 and further increase the production of Aβ of cells. Faghihi et al.23 found that the microRNA miR-485-5p, sharing the same binding sites with BACE1 to BACE1 mRNA, inhibited the expression of BACE1 through competition.