Similarly, although the populations undergoing or not undergoing ophthalmoscopy were likely not identical, we did not observe an impact of routine ophthalmoscopy on clinical outcome. Performance of the examination resulted in a change in antifungal therapy in only 5.6% of the 168 patients. On the contrary, ophthalmoscopy generates an increase in hospital costs ($400 per consultation), is uncomfortable for patients, and carries a small risk of acute angle-closure glaucoma .