Ribosomes, the workplace for protein biosynthesis, are directly associated with translation, cell growth, cell cycle, localization, and cell proliferation . In our present study, the ribosome is the most prominent pathway (P value: 1.130046e − 12). In 2011, the first complete atomic structure of eukaryotic 80S ribosome from the yeast Saccharomyces cerevisiae was obtained by crystallography. The assembly model of 80S ribosomes requires the joining of 40S and 60S subunits , which reveals the architecture of eukaryote-specific elements and their interaction with the universally conserved core. During translation initiation, the 40S subunit is interactive with eukaryotic translation initiation factor 1 (eIF1) and 60S subunit is in complex with eIF6. The core of the 60S subunit is formed by the 28S ribosomal RNA, which contributes the active site of the ribosome [47, 48].