SEATTLE II enrolled 150 patients and showed a prompt reduction in the right ventricular (RV)-to-left ventricular (LV) diameter ratio, pulmonary artery systolic pressure, and pulmonary angiographic obstruction at 48 hours without any ICH.11 In this exploratory analysis, we evaluate patients who suffered major bleeding events during and after ultrasound-facilitated, catheter-directed, low-dose fibrinolysis to identify risk factors for bleeding.