Copaiba oleoresin has shown antibacterial activity against several strains, in particular, Gram-positive Bacillus subtilis and Staphylococcus aureus with minimum inhibitory concentration (MIC) values of 5 μg/mL for both organisms . Copalic acid, isolated from C. langsdorffii, showed excellent antibacterial activity against Bacillus cereus (MIC 8.0 μg/mL), B. subtilis (MIC 5.0 μg/mL), Kocuria rhizophila (MIC 5.0 μg/mL), Streptococcus pyogenes (MIC 3.0 μg/mL), S. pneumoniae (MIC 3.0 μg/mL), S. agalactiae (MIC 2.0 μg/mL), S. dysgalactiae (MIC 1.0 μg/mL), S. epidermidis (MIC 0.5 μg/mL) , S. salivarius (MIC 2.0 μg/mL), S. mutans (MIC 3.0 μg/mL), S. mitis (MIC 5.0 μg/mL), S. sobrinus (MIC 3.0 μg/mL), and S. sanguinis (MIC 6.0 μg/mL) . Likewise, kaurenoic acid showed remarkable activity against S. pyogenes (MIC 5.0 μg/mL), S. pneumoniae (MIC 5.0 μg/mL), S. dysgalactiae (MIC 8.0 μg/mL) , S. epidermidis (MIC 4–5 μg/mL), B. subtilis (MIC 3.1–6.3 μg/mL), and S. aureus (MIC 8–10 μg/mL) . 3α-Alepterolic acid acetate (acetoxycopalic acid) showed moderate antibacterial activity against cariogenic Streptococcus bacteria, with MIC values ranging from 12.0 to 60.0 μg/mL . ent-Polyalthic acid also showed moderate antibacterial activity against B. subtilis (MIC 20–30 μg/mL), S. aureus (MIC 40–50 μg/mL), and S. epidermidis (MIC 40 μg/mL) .