Given that aging is also one of the major risks of neurodegenerative diseases, the role of lncRNA in aging cannot be overlooked. Zhang et al.35 have identified 97 significantly upregulated and 114 significantly downregulated lncRNA transcripts from the senescence-accelerated mouse prone 8 (SAMP8) and senescence-accelerated mouse resistant 1 (SAMR1) models. These significantly dysregulated lncRNAs were involved in nerve growth factor term, the mitogen-activated protein kinase signaling pathway, and the AD pathway, thus regulating the development of AD.