This study reports that type (aerobic and strength) and frequency of exercise are related to a variety of clinical laboratory tests in healthy young adult men and women. In many cases the direction of the influence of exercise could be suggestive of better health. Yet mode of exercise and gender influenced the relationships between exercise and biomarker results for several measures for undefined reasons that require follow-up studies. Reported relationships may help in the understanding and interpretation of common laboratory results and avoid potential misinterpretation of acceptable results that may be a healthy adaptation to exercise training. Results may contribute to the eventual generation of laboratory reference intervals that are more appropriate based on factors such as physical activity.