Such an action of NE on placental tissues may aid in deciphering characteristic changes or alterations in this organ in GDM, which include increased size, enhanced angiogenesis, and most notably significant villous immaturity (48). The latter is clinically highly relevant as it is associated with poor fetal outcome (48). In addition, fibrin thrombi have been detected attached to the syncytiotrophoblast in placentae affected by GDM (48), a feature also detected in cases with PE (55). It is noteworthy that these placental alterations are frequently evident even in well-managed cases with GDM. It will, thus, be of interest to determine what the contribution of neutrophils is concerning GDM-related placental alterations, specifically villous immaturity and thrombotic events in the intervillous space. It will also be interesting to discern how these are related to the onset of PE.