According to Vavourakis et al. , a 3D patient-specific biomechanical FEM of the breast can be created from MRI data (Figure 2A), that is segmented to delineate breast and background (Figure 2B). Fat and fibroglandular tissues can also be differentiated to create a more detailed FEM, in which distinct mechanical properties are assigned to elements according to the breast tissues they represent. Upon the segmentation of the structures of interest, a 2D surface mesh of FE that represents skin and a 3D mesh representing the interior of the breast shall be generated (Figure 2C).