If the first coupling product (Nu − E) can be made to react subsequently with further electrophiles through catalysis, 1:2 and/or 1:3 adducts (i.e. Nu-E2, Nu-E3) can be obtained. Although reactions of this type can be seen as over-reactions (eq. 2), such multicomponent coupling reactions are fascinating due to their potential as a direct approach toward highly functionalized advanced materials. List et al. reported an outstanding example: the condensation of acetaldehyde with two molecules of N-Boc imine using 20 mol% proline as a catalyst, which was originally developed for a single condensation reaction2. In order to utilize the double condensation reaction as a rational asymmetric catalytic reaction, new concepts for the design of highly active catalysts are required, and the first coupling product must be smoothly introduced to the second coupling reaction while avoiding the reverse reaction. Here, we report the design and development of a dinuclear palladium catalyst that enables a novel double Mannich reaction.