We speculate that GSN overexpression inhibits cell proliferation and invasion and promotes apoptosis of YTS cells, at least partially through suppressing the PI3K/Akt signaling pathway, which is closely related to NKTCL and might have an antitumor effect. However, to our knowledge, relevant reports on the association between GSN and NKTCL are relatively few. Therefore, the specific pathogenesis requires further investigation.