We have previously established that miR-128 interacts with the coding sequence (CDS) of the reverse transcriptase component of long interspersed element 1 (LINE-1) retrotransposons (ORF2), preventing retrotransposition, genomic integration and mutagenesis . Interestingly, the activity of L1 and telomerase is closely intertwined. Specifically, L1 retrotransposons can provide an alternative mechanism to maintain telomere structure in organisms from Drosophila melanogaster to humans and L1 activity has been reported to induce hTERT mRNA levels and telomerase activity in tumor cell lines [51–53].