A vaccine for human immunodeficiency virus type-1 (HIV-1) is a global health priority. Attempts are underway in designing HIV-1 immunogens that can elicit correlates of protection (1, 2). Using the reverse vaccinology approach, broadly neutralizing antibodies (bnAbs) are being used to map the neutralizing determinants that can be incorporated into an immunogen based vaccine that will be effective in eliciting similar antibodies in natural infection (2, 3). Majority of the bnAbs isolated so far are from non-subtype C infected individuals and except a few, not much effective against subtype C viruses (4–8).