Most surveys have concluded that the prevalence and severity of the RLS both increase with age (Phillips et al., 2000; Ohayon and Roth, 2002), suggesting that the neurodegenerative process may play an important role in RLS. Life style of older people and the senile changes including cardiovascular changes and metabolism changes is also related to RLS (Koh et al., 2015; Cassel et al., 2016). In adults, the incidence of RLS is twice as high in women than in men (Berger et al., 2004), which may result from the hormones such as estrogen and progesterone and different social roles.