Increased CD4 T cell trafficking could eliminate persistent replication by promoting infected cells out of drug sanctuaries and into regions with clinically effective drug concentrations where the virus they produce cannot infect uninfected cells. As the average number of secondary infections arising from each infected cell is reduced, ongoing cycles of viral replication no longer remain sustainable. Thus, a novel way to address the problem of concentrations of drugs that are low is to promote the trafficking of infected cells away from drug sanctuaries to anatomical regions where antiretroviral drugs penetrate effectively.