Gestational diabetes mellitus (GDM) is a unique form of glucose intolerance exclusive to pregnancy and that by nature it is transient (1, 2). Since GDM may share some similarities with Type 2 diabetes mellitus (T2DM), such as insulin resistance or features of the metabolic syndrome, it has been suggested that GDM may be considered a pre-diabetic state or a momentary unmasking of a T2DM-like condition (2). Additionally, the autoimmune component evident in Type 1 diabetes mellitus (T1DM) is not evident in GDM (1, 2). Fueled by the pandemic in obesity and associated metabolic syndrome, GDM is rapidly becoming a global health-care concern, particularly as it may significantly increase the incidence in T2DM due to the contribution of two parties, mother and child (3). In order to be able to undertake effective countermeasures to avert or reduce this scenario, a more precise knowledge of the underlying etiology is required to facilitate the development of efficacious therapeutic strategies (4).