All LNA/DNA mixmers were synthesized by Exiqon. Each mixmer sequence was examined by BLAST software to check for any potential negative off-target effects. The mock AON sequence is +T*A* +A*C* +A*C* +G*T* +C*T* +A*T* +A*C* +G*C* +C*C* +A. Phosphorothioated DNA base: G*, A*, T*, C*. Phosphorothioated LNA base: +G*, +A*, +T*, +C*.