It is to be noted and emphasized that the information extracted from the metabolomics raw data and the resulting outputs depend heavily on the data analysis methodology employed. Additionally, in the hierarchy of data, information, and knowledge, the logical and epistemological implication is that information is the key to knowledge formulation . In order to maximize the value of metabolomic data and generate biologically-meaningful hypotheses, particularly with regard to the regulatory mechanisms and molecular processes involved in global biological responses (such as those of a biosystem), the metabolomics raw data are to be appropriately handled and fully exploited. This will ensure the extraction of sufficient information to determine, as holistically as possible, biological components that show differential behaviors between experimental conditions .