In conclusion, the present investigation indicates that the decoction comprised of N. sativa seeds, H. indicus roots, and S. glabra rhizomes has the potential to protect against cytogenetic damage inflicted by bleomycin in human peripheral lymphocytes. Since the decoction under current investigation has previously been reported to mediate anticancer effect against certain malignancies, the observed radioprotective potential has a definite clinical advantage during its use among cancer patients. Thus, it could protect the patient against radiation induced cell damage while restricting tumour progression.