The regulation of telomerase activity in healthy cells and in cancer is complex and includes genomic rearrangements, as well as regulation by cellular factors including (but not limited to): Proteinase-activated receptor 1 (PAR1), Telomeric Repeat Factor 1 (TRF1), the Kinase, Endopeptidase and Other Proteins of small Size complex (KEOPS complex) and the Laminin Receptor (LRP) [45–50].