DHX29 is expressed in human tissues and immune cells, especially high in prostate, spleen, mammary gland, testis, kidney and thymus using two sets of primers (#1 and #2) (Fig 1G). In addition to high expression of DHX29 in human lung cells , we showed that DHX29 protein could be detected in human peripheral blood mononuclear cells (PBMCs), monocyte, B cells, T cells, dendritic cells as well as in mouse T cells, B cells, bone marrow derived dendritic cells (BMDCs), peritoneal macrophages, bone marrow derived macrophages (BMDMs) and neutrophils (Fig 1H). Thus, our systematic investigation indicates that DHX29 is ubiquitously expressed in all tissues and cell types tested from human and mice, albeit with different expression levels, suggesting that DHX29 might have cell-type specific function in response to viral infection.