It should be noted that, when simulating intrinsic electroresponsiveness with somatic recordings, LVA Ca channels and KCa channels proved either noncritical or subcritical (Masoli et al., 2015). Therefore, in light of the present simulations, the tuning procedures of maximum ionic conductances in neuronal models should be targeted toward features addressing synaptic response pattern (Marasco et al., 2013) rather than just responses generated by somatic current injection (Druckmann et al., 2007, 2008; Masoli et al., 2015, 2017). Since some of these channels are located in the spines (specifically Cav3.1), a future assessment of the impact of spines in the PC model is warranted.