Dirichlet regression implicated each relevant habitat with pathway alterations due to unique upstream transcriptional regulators and signaling activity. Imaging-derived habitats also showed some common cellular processes and pathway activity, such as natural killer cell and STAT-1 signaling. These findings are consistent with hallmarks of cancer [21, 22], such as avoiding cell death (natural killer cell) and inducing angiogenesis (tyrosine phosphorylation of STAT-1).