In current study, we showed that supaglutide enhanced glucose excursion and insulin sensitivity in obese mice. To certain extent, the rate of glucose excursion (IPGTT) depends on body's responsiveness to insulin. We observed that supaglutide significantly decreased hepatic levels of NEFA in obese mice. Since elevated hepatic NEFA can cause liver insulin resistance (Hirabara et al., 2010), it is conceivable that improved lipid metabolism in the obese mice that contributed to improved insulin sensitivity and glucose metabolism in the obese mice.