In this current meta-analysis, we performed an integration of the current evidence (14 studies including 2179 cases) and provided a more stable and convincing result. The results of this current meta-analysis indicate high pretreatment plasma D-dimer could predict poor survival of colorectal cancer (HR = 2.143, 95% CI: 1.922–2.390). Subgroup analysis according to region, treatment and statistical method for survival, also showed consistent results: D-dimer could act as a predictive factor of survival both in the patients undergoing surgery, and the ones with metastasis received chemotherapy. The heterogeneity test and publication bias test all demonstrated the conclusion of the meta-analysis was stable.