Strikingly, the PRO2 and INT6 sites were directly flanked or in close proximity to a total of four PolyA motifs of variable length ([A]7-11), one of which represented a so-called CArG-box, a potential binding site for MADS-box transcription factors (Zhang et al., 2016). Two more PolyA motifs resided in introns 3 and 5 (Figure 4D and Figure 4—figure supplement 1A). Since PolyA motifs had been reported to be important for gene expression, we reasoned that these motifs could be relevant for FLM regulation, in isolation or in combination with the highly significant non-coding variations (O'Malley et al., 2016; Horton et al., 2012).