The present study revealed that stimulation of the ulnar nerve suppressed cocaine-induced hyperlocomotion and the effects were completely abolished by lesions to the DC pathway and LHb, but not to the STT. Additionally, activation of the DC pathway or the LHb was detected following ulnar MS. These findings strongly suggest that the DC somatosensory pathway conveys an inhibitory signal from the periphery to mesolimbic reward circuits and the activation of spinal DC pathway can inhibit psychomotor response to cocaine.