The primary safety outcome was major bleeding within 72 hours of initiation of the procedure. Bleeding events were classified by the Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries (GUSTO) bleeding criteria.12 Major bleeding was defined as either GUSTO moderate or GUSTO severe/life-threatening bleeding events. All monitoring for major bleeding within 72 hours was performed during the hospitalization. All bleeding complications were adjudicated by a designated independent Study Safety Monitor.