Fig 5 shows model predictions of the impact of changes to the trafficking rate or enhanced immune control upon the dynamics of susceptible and infected CD4 T cells in patients taking antiretroviral therapy. In these simulations, prior to time 0, infected cell numbers under antiretroviral therapy are assumed to have reached an equilibrium state due to continuous replication in drug sanctuaries. After time 0, trafficking therapy, immune therapy or both are applied. Fig 5A shows that if the CD4 T cell trafficking rate is increased above the defined critical threshold there is a transient increase in infected cells in the main compartment as cells are washed out of the drug sanctuaries into the main compartment. Following this, infected cell counts in both compartments decline as replication becomes unsustainable in the drug sanctuaries.