L.B., G.L. and E.M. conceived and designed research. G.L., L.B., J.P., R.d.B.F., A.E., C.G., M.S., O.H., J.S., C.M. conducted experiments. L.B., G.L. R.d.B.F. and E.M. analyzed data. L.B., G.L., J.P., R.d.B.F., A.W., E.S. and E.M. wrote the manuscript. All authors read and approved the manuscript.