Of the 316 consenting patients with available CTPA, we excluded 24 patients with inadequate CTPA quality and one patient with cancer-related non-thrombotic obstruction, leaving a final study sample of 291 patients with acute PE. Analyzed patients had a median age of 75 years (interquartile range [IQR] 69–81), 138 (47%) were women, 69 (24%) had provoked and 45 (15%) had cancer-related VTE (Table 1). Overall, 29%, 55%, and 16% of patients had a CTOI of <15%, 15–50%, and >50%, respectively. Patients with a higher CTOI were significantly younger (P = 0.01), had more often an unprovoked PE (P = 0.047), a higher BMI (P = 0.01), a higher rate of thrombolysis (P <0.001), a longer duration of anticoagulation (P = 0.003) and a higher RV/LV diameter ratio (P <0.001) (Table 1). Median follow-up was 31 months (IQR 24–42 months). Overall, 5% (15/291) of patients died within 90 days (6 from definite or possible PE). During the whole follow-up, 12% (34/291) of patients had a recurrent VTE (16 patients within 12 months). Median LOS was 8 days (IQR 5–12 days).