Calpastatin overexpression protects against brain aging. The mean astrocytic lenght decreases with aging in the CA1 area of the hippocampus. This lenght was similar in 2-months old (2 mo) animals (A,B,E, magnification ×600). Aged CalpTG (TG) mice were less affected by this decrease than 2 years (2 yr) old WT mice (C,D,E, *p < 0.05, n = 6/group, magnification ×600).