The fact that our meta-analysis looked at preschool wheeze altogether, without separation for viral-induced or multiple-trigger wheeze, is a great strength of the current analysis compared to other meta-analyses . A recent international consensus report disputes the use of such terms in preschool wheeze , as it seems that there is huge overlap between these phenotypes as well as change over time; thus, separating patients in this way may not be clinically relevant. This makes our study more clinically applicable to the general population.