(A) Tumor volumes (n = 6 mice/group) were assessed by noninvasive bioluminescence imaging system and representative images taken at different days were shown in left panel. Quantification of the bioluminescence signal was plotted in right panel. P < 0.05. (B) Overall survival was calculated through Kaplan-Meier survival curves and the log-rank test was applied to estimate p-value between two groups. (C) IHC sections came from tumor slices were stained with CBX7 and Cyclin E1 and the representative profiles were demonstrated.