The marine sponges are collected from Rameswaram Coast, Tamil Nadu by SCUBA diving and they are extracted using hexane solvent. The compounds are isolated using column chromatography and the identification of the isolated compounds is accomplished using spectroscopic methods like GCMS and NMR. The compounds are confirmed as Stigmasterol and Oleic acid; these two compounds are considered to be the ligands for docking analysis against Human Epidermal Growth Factor Receptor 2 (RCSB PDB code 1N8Z). A comparison of the docking results of the breast cancer drugs with the natural compounds isolated from marine sponges Aurora globostellata, against the HER2 has been carried out to estimate the quality of the isolated compounds to act as drug like molecules equivalent to that of the commercial drugs.