According to the onset age of the symptoms, RLS is divided into early-onset RLS and late-onset RLS. Early-onset RLS refers to those who firstly have the symptoms before 45 years old. While late-onset RLS patients have the symptoms from or after 45 years old. A higher familial history rate was found in early-onset RLS comparing to late-onset RLS (Kotagal and Silber, 2004). Various clinical courses with periodic remissions are common in early-onset RLS. While a chronic progressive clinical course with more severe symptoms are seen in late-onset RLS. Pediatric RLS are always misdiagnosed as “growing pain”. Current researches demonstrate a relatively iron deficiency and renal failure to be exacerbating factors for pediatric RLS (Kotagal and Silber, 2004; Davis et al., 2005; Applebee et al., 2009; Sinha et al., 2009). Commonly pediatric RLS should be differentiated from ADHD while only RLS patients presents the need to move because of leg discomfort but not difficulty “sitting still” (Trenkwalder et al., 2005).