Integrase E157Q substitution has been described as a polymorphism present in 2.4% of viral sequences obtained from cART-naïve patients in the ARCA Italian database and in 5.0% in the last French transmitted drug resistance survey study . A recent study of the French ANRS AC11 virology network conducted on 8528 integrase sequences from INI-naïve patients showed that the overall prevalence of E157Q polymorphism was 2.7% and its distribution among HIV-1 subtypes was 1.7%, 5.6% and 2.2% in B, CRF02_AG and others non-B subtypes, respectively .