Several Copaifera oleoresin oils have shown in vitro antiparasitic activity against Leishmania amazonensis promastigotes, including C. cearensis, C. langsdorffii, C. lucens, C. martii, C. multijuga, C. officinalis, C. paupera, and C. reticulata . The resin oil of C. martii showed in vivo antileishmanial activity in a mouse model  and C. reticulata resin oil showed activity against L. amazonensis axenic amastigotes (IC50 = 15.0 μg/mL) and intracellular amastigotes (IC50 = 20 μg/mL) . Diterpenoids isolated from C. officinalis—agathic acid, alepterolic acid, kaurenoic acid, methyl copalate, pinifolic acid, and ent-polyalthic acid—showed antileishmanial activity against L. amazonensis promastigotes .