We aim to quantify treatment effects for typical AGR patients. Therefore, we will exclude participants with rare conditions which are likely to affect the health course beyond the effects which can be reasonably assumed from AGR (e.g. organ transplantation, dialysis, chemotherapy) or participants with extremely high health care costs indicating severe conditions. Prespecified criteria used to exclude AGR participants from our analyses are shown in Table 3. Exclusion criteria for AGR participants also apply to potential controls.Table 3Criteria for the exclusion of AGR participants for study analysisExclusion criteria- Age <70 or >95 years in the intervention billing periodPrior to the intervention billing period:- nursing care >2- <360 insured days in the four previous billing periods- living in a nursing home- hospital costs without out of pocket spending at the last billing period >33.000 €- hospital costs without out of pocket spending during the four last billing periods ≥44.000 €- ambulatory costs during the last billing period ≥2.200 €- ambulatory costs during the four last billing periods ∑ ≥5.500€- remedy costs without out of pocket spending during the four previous billing periods ≥2.200 €- costs of aid without out of pocket spending during the four previous billing periods ≥4.000 €- drug costs without out of pocket spending during the four previous billing periods AGR ≥11.000 €- total health care costs without out of pocket spending during the four previous billing periods ≥44.000 €- diagnosed AIDS/HIV in the four previous billing periods- chemotherapy in the four previous billing periods- organ transplantation during the four previous billing periods- dialysis during the four previous billing periods