Since its discovery by two independent groups in 2010 , LukAB/LukGH has garnered attention as an important S. aureus virulence factor based on its clear role in both ex vivo and in vivo models of disease . Infection of human neutrophils with diverse S. aureus strains indicates that LukAB/LukGH is the dominant toxin responsible for neutrophil targeting and killing . This toxin is also highly conserved, being present in the genome of all known clinical isolates tested to date . Finally, LukAB/LukGH is clearly produced during human infection, as evidenced by its recognition by the humoral response following invasive human disease .