“Two alternative isomerization reactions that would also facilitate lagging strand block bypass without displacement include one in which Mcm10 cracks open the N-tier of the Mcm2-7 ring of CMG, bypasses the block, and recloses the N-tier. Similarly, Mcm10 might enable opening of both the N- and C-tiers, either simultaneously or in succession, to bypass the blocks. These alternative isomerization reactions are described in detail in Figure 8 of (Langston et al., 2017)”