Bevacizumab, a humanized monoclonal antibody against VEGF-A, has been approved as combination therapy or monotherapy for first- and second-line treatment of several advanced cancers, including metastatic colorectal cancer (mCRC), metastatic renal cell carcinoma (mRCC), metastatic non-small cell lung cancer (NSCLC), progressive glioblastoma, metastatic cervical cancer and ovarian cancer etc. . In TCGA dataset, high miR-378 expression was associated with poor progression-free survival (PFS) in recurrent ovarian cancer patients treated with bevacizumab (low vs. high, 9.2 vs. 4.2 months; p = 0.04). Multivariate analysis revealed that miR-378 expression was an independent predictor for PFS after anti-angiogenic treatment . For patients with mCRC treated with first line CAPEOX (capecitabine and oxaliplatin) alone, or CAPEOX and bevacizumab (CAPEOXBEV), predictive miRNAs for therapy effectiveness were identified using PCR arrays. Higher miR-664-3p level and lower miR-455-5p level were predictive of improved outcome in the CAPEOXBEV cohorts and showed a significant interaction with bevacizumab effectiveness .