The data combination of this meta-analysis was carried out by Stata 12.0. The prognostic value of plasma D-dimer in pretreatment colorectal cancer patients was evaluated via combined HR together with corresponding 95% CI. Q test as well as I2 statistic was utilized to estimate the heterogeneity of the pooled articles. In the meta-analysis, a model of fixed-effect was selected if heterogeneity of pooled studies was acceptable (P > 0.1 and I2 < 50%) . If not, we used a model of random-effect to combine the HR. The publication bias was examined by Egger's test and P < 0.05 indicates statistical significance.