Upregulation of Ucp1 protein is a key element in maintaining core body temperature, especially when the body exposed to cold environment (Cannon and Nedergaard, 2004). Here, we found the drug treated-mice had a trend of higher core body temperature when housed in room temperature and kept higher rectal temperature when they were exposed to cold environment, displaying activated thermogenesis compared with the control group (Figure 8). This result shows that supaglutide was able to increase body adaptation to cold exposure by generating more heat.