In this study, we hypothesize that using a facile and green route to create graphene oxides crosslinked with divalent cations such as calcium, zinc or strontium will yield three-dimensional GO networks that can be safely used for biomedical applications by virtue of the synthetic route and enable composite formulation with enhanced mechanical properties, which is exemplified through forming GO/calcium alginate composites in comparison to the use of single GO nanosheets and consequently also provide a simple process to include cations that enhance antibacterial effects and in trace amounts facilitate bone healing, thus can be explored for scaffolds for bone and wound healing applications.