The greatest changes occurred in GS > 7 group where we observed several H3K27me3-enriched genes such as MGMT, SLC4A4, ABHD2, PAPOLG, NSF, ING3, TMPRSS6, FNDC3B (Fig. 3).Fig. 3Hierarchical clustering analyses of patients with Gleason score > 7. The scaled enrichment score of individual patients is plotted in a red-yellow scale. Color intensity reflects magnitude of enrichment score, with red indicating high H3K27me3 enrichment and yellow indicating low H3K27me3 enrichment. Columns represent individual tissues. Rows represent the genes. The dendogram represents overall similarities in patient profiles