Prostate cancer is the most common malignancy and the second most common cause of cancer death among men in the United States.1 Multiple molecular alterations have been identified in prostate cancer initiation, growth, invasion and metastasis. Further investigations are needed to understand the mechanisms of dysregulation and role in tumorigenesis of many of the dysregulated genes that are implicated in cancer. These studies will enhance the understanding of the disease process and help in developing new therapies. High-throughput gene expression profiling studies and transcriptome analyses have revealed tumor-specific gene signatures and multiple oncogenic drivers in cancers.2, 3, 4, 5, 6, 7, 8, 9, 10