Colorectal cancer, as a malignant neoplasm with high incidence worldwide, owns unsatisfied survival in advanced stage due to metastasis, recurrence and resistance of chemotherapy [1, 25, 26]. Thus, an efficacious biomarker to predict the prognosis of colorectal cancer is necessary, thereby providing potential target for treatment. D-dimer is a clinically common marker of activation of coagulation system. Increasing evidence showed that malignant neoplasm could promote the activation of coagulation, and elevated D-dimer was detected in several cancers which correlated to the prognosis, including in lung cancer, gastric cancer, and colorectal cancer [27–29]. Ma et al. have demonstrated high D-dimer predicted worse survival in lung cancer by a meta-analysis . However, regarding colorectal cancer, the prognostic value of D-dimer was contentious based on the published studies.