Currently, there are three main functions in this program. (1) Predict the bitterant after loading the molecule into e-Bitter program. Batch function is also developed to screen the bitter compounds against the small-molecule database. (2) Visualize the fingerprint bit in the context of 3D structure, view the feature importance of fingerprint bit contributing to the bitterant/non-bitterant classification and look over the feature partial derivative of fingerprint bit reflecting the negative or positive influence on the bitterness. (3) Check whether the compound of users' interests is located within the applicability domain of our models.