The above-mentioned studies prove the significance of monitoring naive CD4+ cell in the follow-up of our patients and our results are in agreement with them. Higher levels of naive CD4+ cells were shown to be a positive prognostic factor in our study, specifically more than 52.3% of naive cells in CD4+ cells and 64.6% of all naive lymphocytes. A reduction of naive helper cells by one third (exactly 30.5% in relationship to baseline) and only a slight reduction of total CD45RA+ lymphocytes (4.1% in relationship to baseline, statistically significant in the first, third and fourth year of follow-up) was associated with clinical worsening (CDP). According to these results, we could use monitoring of naïve CD4 + changes as an important predictive factor, but further studies will be required to examine the optimal frequency of (monitoring) measurement.