Firstly, we identified probes differentially expressed at each time step while taking blood cell composition into account. Blood cell composition was measured by the L/G ratio. Three models (one for each time step t ′ where t ′∈{+1,+4,+24}) were fitted to each probe using observations at t=0 and t=t ′. 1\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document} $$ \text{expr}_{{it}} = \mu_{0} + \tau_{t'}\mathbb{I}_{\{t = t'\}} + \beta^{t'} L/G_{{it}} + \epsilon_{{it}} $$ \end{document}exprit=μ0+τt′𝕀{t=t′}+βt′L/Git+εit