The incidence of endophthalmitis after MIVS reported in literature in the last decade have shown a declining trend. In a large, multicenter retrospective Pan-American Collaborative Retina Study Group, Wu et al. found an incidence of 0.026% (2.6 cases per 10,000 surgeries) for endophthalmitis after MIVS during 2005–2009. Scott et al. in their multicenter retrospective study found an incidence of 0.048% (4.8 cases per 10,000 surgeries) for endophthalmitis after MIVS during 2007–2008. They also found that the rate of endophthalmitis after MIVS in their study period was marginally lower than that estimated for 2005–2006, suggesting the decreasing trend. Similar indisputable decreasing trend is evident in our study (Fig 1) with the rate decreasing from 0.082% to 0.010% in the last decade. Lower rates observed in our study compared with previous studies are possibly due to the various reasons. As the incidence of endophthalmitis in the MIVS group is calculated for 2009–2014, we ascribe these lower rates to the decreasing trend observed in the past. Also, as our data represent the incidence from a single center, data are possibly less heterogeneous in terms of inclusion criteria, antibiotic prophylaxis, standard infection prevention protocols, and surgical technique except for those that have evolved over time. Moreover, the inclusion criteria of our study is more robust. We included only those cases that had an unusual post-operative inflammation sufficient enough to warrant a microbiological evaluation of ocular fluids and had microbiological evidence (staining positive/culture positive/PCR positive) of the same.