Matrix metalloproteinases (MMPs) are believed to have an essential role in the inflammation process and carcinogenesis, by causing degradation and remodelling of the extracellular matrix and basal membrane. MMP are secreted through transmembrane endoproteinases. MMP has a catalytic zinc domain, which is required for proteolytic activity. MMP are able to degrade at least one extracellular matrix component. MMP-7 and MMP-9 are members of the MMP family, which increase in H. pylori gastritis and in early gastric carcinoma .