Lower baseline plasmic DPD [>119.200 vs. ≤119.200, harzard ratio (HR) 2.931 (1.155–7.433), P = 0.024] was significantly independent predictor of prolonged OS (supplementary Table S7; Fig. 4).Fig. 4Kaplan–Meier curve of overall survival according to baseline plasmic DPD expression. DPD dihydropyrimidine dehydrogenase