The potential predisposing factors identified in our study were as follows: diabetes (46.7%), vitrectomy for vascular retinopathies (44.4%), vitrectomy combined with anterior segment procedures (35.5%), and absence of tamponade (59.5%). History of intraocular surgery was more often seen in patients in the MIVS group. Diabetes, and immune-compromised states, can theoretically increase the risk of endophthalmitis after vitrectomy. Complicated vitreoretinal surgeries requiring multiple exchange of instruments, longer operative time, increased incidence of cataract requiring combined anterior segment surgeries, and poor wound healing can increase the risk of endophthalmitis. Similar associations have been noted in other studies.[1–5,7,9]1–5,7,9