Several advances have emerged in precision and personalized medicine which could potentially benefit the field of oral pathology vis-à-vis molecular oral cancer diagnostics and therapy. The advent of microfluidic technology [201, 202] has made it possible to establish a rapid multistage, multi-technique technology known as Lab-on a-chip [202, 203]. This has permitted a high turnover of requested laboratory investigations during clinical diagnosis and therapy. This technology and those mentioned above have rapidly improved the development of point-of-care (POC) diagnostic tools [204–206]. These developments may have potential applications for oral pathology and cancer management. It is also clear that stem cell science has improved the field of dentistry and oral pathology. Somatic stem cells can be harvested from patients and reprogrammed to form patient-specific induced pluripotent stem (iPS) cells . These iPS cells can be used for recombination and regenerative production of maxillofacial structures for transplantation and maxillofacial structure reconstruction . On the other hand, subpopulations of cancer stems cells have been previously identified in head and neck cancers, by the application of stem cell science . Such in-depth knowledge can also provide future stem cell-based targeted therapies against head and neck cancers . Quantum medicine approaches such as quantum tunneling  has been previously used in understanding genetic mutations in cancers . A quantum mechanical approach is now being considered in the understanding of the evolution of cancers [211, 212]. There is no doubt that these emerging molecular concepts are poised to play a major role in oral pathology and cancer diagnosis; as well as therapies in the foreseeable future.