However, careful examination of the AHO resistance measurements resulted in two more observations. First, even after TM removal, some level of resistance was still recorded implying potential sources of resistance distal to the TM (Table 1; ”Resistance after Trabeculotomy” values). Second, glaucoma eyes showed greater post-TM resistance values (2.53 mm Hg × min/microliters) compared to normal eyes (1.26 mm Hg × min/microliters) (Table 1; red arrow) implying that the post-TM AHO regions were also effected in glaucoma. In fact, the increase in TM (Table 1; green arrow; 2.7 fold) and post-TM (Table 1; red arrow; 2 fold) resistance in glaucoma were nearly equivalent. This suggested that glaucoma was not only a TM outflow resistance problem but potentially a whole-eye disease where mechanisms to explain impaired outflow would have to explain both TM and post-TM changes.