The field of molecular biology has undergone significant evolution in the post-genomic era [93–97]. With the emergence of omics-based approaches, research capabilities have expanded from low to medium throughput biochemistry, to interrogation of the full complement of biomolecules in a high throughput manner. Further, biological molecule have now been characterized in a manner that was hitherto not possible . A few relevant high throughput omics based methods are described hereafter as they relate to the field of oral pathology and cancer.