PCs are endowed with hundred thousand spines (O’Brien and Unwin, 2006), each one receiving a single contact from an aa or a parallel fibers (pf) synapse (Walter et al., 2009). While spines may be critical to implement local biochemical processing during synaptic transmission, they have been suggested to generate linear attenuation with little impact on the overall synaptic excitation process (Ly et al., 2016). Therefore, spines were not reconstructed in the model and excitatory synapses were placed directly on the dendrites. The dendrites were divided into three orders of branching [branch I, composed by 105 sections with diameters between 3.5 μm and 9 μm; branch II, composed by 1111 sections with diameters between 1.2 μm and 3.5 μm; branch III, composed by 383 sections with a diameter between 0 μm and 1.2 μm] receiving specific synaptic inputs. Concerning excitatory synapses (Figure 1A), branch II received only pf synapses and branch III received only aa synapses (Santamaria et al., 2007; Lu et al., 2009; Bower, 2010). Branch I should have received a cf input (Kaneko et al., 2011; Zhang et al., 2015) but this was not used here (not shown). Concerning inhibitory synapses (Figure 1A), these were distributed only on branches I and II for a total of 221 sections, since branches III were experimentally reported not to have inhibitory synapses (Lu et al., 2009; Bower, 2010). Inhibitory synapses on branches I and II were made identical, although those on section I may have a different control (He et al., 2015). The inhibitory BC synapses on the soma and AIS (Iwakura et al., 2012; Blot and Barbour, 2014; Kole et al., 2015) were not used here (not shown).