In this work, we have established that among different species of AAP, two strategies for tellurite reduction may be required. First, there is a constitutive membrane associated reduction pathway, as seen in E1, E5, KR99, RB3, and RB 16-17. The second, requires de novo protein synthesis and fully functional unbroken cells, found in strain E4(1). The identified approaches were not completely unexpected as similarities exist to previously established physiological responses to metal(loid) oxyanions. Membrane associated metal(loid) reduction has been previously observed in R. capsulatus and Enterobacter cloacae EV-SA01 . There is also precedent for the need of fully intact cells . It is likely that there are several integral components associated with the outer membrane, periplasm, and inner membrane which are all involved in reducing tellurite. Hence, removal of one component results in loss of function of the entire system. This complex coordinated arrangement is published for reduction of other metal oxyanions .