Of the above risk factors, each score for the following five main risk factors [female sex, age of 75 years or older, low body weight (50 kg or less), severe cardiovascular disease (Killip Class III or IV), and severe renal impairment (creatinine clearance less than 30 mL/min)] is defined as 1. We calculated the total risk score and the incidence of bleeding AEs. By this analysis (Fig. 3), we found that the bleeding risk increased sharply in patients who had four or all five risk factors.Fig. 3Bleeding adverse events by number of risk factors. AEs adverse events, Ccr creatinine clearance. *The score of the risk factors was not calculated in 55 patients