A second project (‘Relationship between CAN and neuroendocrine response to stress in individuals with SUD’; PI: Ingo Schäfer, Hamburg) examines relationships between CAN and neuroendocrine reactions to social stress in patients with alcohol dependence (AD). To this aim, N = 72 male and female AD patients (with and without childhood trauma) will be compared to N = 72 healthy controls (with and without childhood trauma) regarding their reactions to a social stress task (‘Trier Social Stress Test’; TSST). Other markers (e.g. hair cortisol levels) will be used to get a more holistic view of potential relationships between CAN and stress reactivity in AD patients and to identify their potential predictive value. It is expected that individuals with AD and CAN show decreased cortisol responses to the TSST as compared to AD individuals without CAN, the latter being comparable to healthy controls with CAN.