Furthermore, we evaluated the relationship between patient clinicopathologic features and telomere length in tumor cells or CAFs. Reduced intensity of telomere signals in tumor cells correlated positively with larger tumor size (p < 0.001), the presence of vascular invasion (p = 0.046), poor tumor differentiation (p = 0.041), and advanced tumor stages (p = 0.001). Similarly, shorter telomeres in CAFs were associated with larger tumor size (p = 0.032) and the presence of vascular invasion (p = 0.031) (Table 1). However, no significance was found between telomere variation and other features, such as hepatitis virus, gender, cirrhosis, tumor encapsulation, and tumor number.