We present the case of a patient with F5D and unstable angina who underwent coronary stenting and antithrombotic maintenance therapy with a single antiplatelet agent due to recurrent multiple mucosal bleeding shortly after coronary stenting. In particular, for the first time, we have described maintenance therapy after coronary stenting in an F5D patient. As F5D is a rare hematological disease with an incidence of approximately 1 in a million, it has no established treatment guidelines. Furthermore, there are no guidelines or studies on antithrombotic therapy after coronary stenting in F5D patients.