miR-484 and miR-744 can be considered as two possible restriction host factors against DENV infection, but the virus might have evolved to resist inhibition by endogenous human miRNAs during productive replication. This finding suggests that DENV RNA is a target of cellular miRNAs. Furthermore, this study contributes to a better understanding of the relationship between host miRNAs and DENV, and recommends further studies to decipher the biological functions of this interaction to develop a therapy based on these two miRNAs for the control of infection and treatment of dengue illnesses.