Plasma FFA did not differ between groups (Table 3). HFr-feeding induced a significant increase in circulating TG, compared to Control-, NASH- and HFD (p < 0.0001, Table 3). Plasma HDL-c levels were similar between groups, as were the plasma cholesterol levels (Table 3). Fasting hyperglycemia was present in all groups compared to Control after 16 weeks (NASH and HFr: p < 0.01, HFD: p < 0.0001, Table 3). However, fasting plasma insulin levels did not differ between groups (Table 3). Circulating leptin levels were significantly increased in the HFD-fed rats compared to both Control- (p < 0.05), NASH- (p < 0.05) and HFr-fed rats (p < 0.01, Table 3).