Polymeric vesicles or polymersomes are synthetic bilayered hollow architectures that are self-assembled from amphiphilic block copolymers . The synthetic nature of polymersomes allows for facile tuning of their properties such as size , membrane permeability  and stability . Various copolymers have been reported for polymersome formation such as poly(ethylene glycol)-b-polystyrene (PEG-b-PS) , polystyrene-b-polyisocyanopeptide (PS-b-PIAT)[21–22] and poly(N-isopropylacrylamide)-b-poly(ethylene oxide) (PNIPAM-b-PEO) . The term “polymersomes” is derived from liposomes because of the structural resemblance. Compared to liposomes, polymersomes are mechanically robust vesicles and therefore considered to be highly attractive for nanoreactor applications . Polymersomes comprise an aqueous lumen and hydrophobic membrane. Such hydrophilic and hydrophobic compartments are capable of accommodating hydrophilic (e.g., enzymes) or hydrophobic catalysts (e.g., metal catalysts) in their lumen or bilayer, respectively . In an aqueous environment the hydrophobic membrane attracts hydrophobic substrates and brings them in proximity to the membrane-bound catalyst, leading to faster reaction rates. The presence of multicompartments in one system is interesting from a catalysis point of view as multistep cascades using incompatible catalysts can be achieved in one polymersome nanoreactor . The compositional versatility of polymersomes thus allows for several applications in catalysis by encapsulating in or tethering catalysts to their compartments . Polymersomes preserve and protect catalysts in their compartments improving, most of the times, catalytic activity and their performance in incompatible solvents such as water .