In agreement with these data, Guillem-Llobat et al. (2016) recently reported that the interaction of platelets with HT29 human colon carcinoma cells leads to the induction of EMT in tumor cells associated to enhanced cell mobility. When the cells were co-cultured with platelets in the presence of ticagrelor, both the down-regulation of E-cadherin, an epithelial cell marker, and the enhanced migratory capacity of HT29 cells were inhibited (Guillem-Llobat et al., 2016). Ticagrelor also caused the simultaneous inhibition of TXB2 (the stable hydrolysis product of TXA2) and of prostaglandin (PG)E2 production, suggesting an inhibitory effect on the release of arachidonic acid from platelet membrane phospholipids (Guillem-Llobat et al., 2016).