The results of our study of a relatively healthy sample, including a low prevalence of morbidities and high HRQoL, suggest that multimorbidity affects HRQoL differently depending on gender or age. Nonetheless, our study is a novel use of multimorbidity patterns to test the impact of multimorbidity on HRQoL. We found two patterns, which were clinically recognizable and theoretically plausible. Further investigations and research in older populations should consider multimorbidity patterns to confirm these findings.