Within each of the two spatial compartments there is homogenous mixing that facilitates the spread of HIV-1 between infected and uninfected CD4 T cells. Though the risk of a cell becoming infected within each compartment comes only from that compartment, there is also trafficking of CD4 T cells between compartments . Principally, we consider the impact of an envisaged therapy that increases the rate at which CD4 T cells traffic between these two compartments. We also investigate the impact of combining such a “trafficking therapy” with therapy that improves immunological control inside drug sanctuaries (“immune therapy”). These spatial dynamics are built upon a standard compartmental model of the impact of antiretroviral drug therapy on the infection of CD4 T cells .