CD54 was found as the surface marker of cancer stem cells of hepatocellular carcinoma, GC and rectal cancer [6, 35, 36]. We found that CD54 was not independently associated with any clinical pathological characteristics and CD54 was not related to prognosis. However, a previous report with 108 patients demonstrated that CD54 was significantly related to advanced stage and liver metastasis . Additionally, many reports found that serum level of soluble CD54 was closely associated with GC progression, hematogenous metastasis and prognosis [7, 8].