Restless legs syndrome affects the patient’s HRQoL to different degrees according to various severities of the symptoms. HRQoL is measured by 36-Item Short Form Health Survey (SF-36), a 36 item survey used to construct eight scales among physical and mental health and health transition. Most patients have mild symptoms, only 11.9% of them seek for consult, while about 3.4% of all the patients need drug treatment (Hening, 2004). The main morbidities except for extreme discomfort were sleep loss and disruption of normal activities (Trenkwalder et al., 2005). Patients with mild or moderate symptoms manifested discomfort with less frequency, lower severity, and less influence of the symptoms on their sleep. Comparing with the general population, patients with severe or very severe RLS symptoms always reported apparent deficits (10–40 points on 100-points scales) in physical functioning, bodily pain, general health, vitality, social functioning, role-physical, and role-emotion (Trenkwalder et al., 2005). With deficient sleep at night, severely affected patients might complain about having difficulty in their daily life including their jobs and social activities (Kushida et al., 2007). A significant higher probability of 25% with ADHD were found in RLS patients compared to general population (Pullen et al., 2011). On the other hand, 20% of ADHD patients meet criteria for RLS as well (Zak et al., 2009; Yilmaz et al., 2011). Pathophysiological pathways of ADHD remains poorly understood, but the most popular theory is the dopamine deficit theory, which could be a shared pathway with RLS (Swanson et al., 2007). BTBD9, a RLS risk allele, may be related to certain subtypes of ADHD, which responds well to iron supplementation treatment (Schimmelmann et al., 2009). Disruption of sleep length and quality, daytime alertness can contribute to depression and anxiety. Increasing sympathetic tone due to PLMS may lead to cardiovascular disease and high blood pressure (Stevens, 2015).