Peak SBP responses during our study exceeded the recommended limit of 200 mmHg to maintain aortic integrity ; as was previously reported, (MacDougall et al., 1992, 1985) fatal events did not occur. Regardless, it would be wise to develop protocols that minimize these peaks to achieve a safer design. Accordingly, stopping the session just after the v-shape during a theoretical CD may help to ensure the lowest values of SBP. In our study, this occurred analytically after the third repetition and descriptively after the third or fourth repetition (Figure 1). Thus, future studies should analyze the pressure response during cluster designs with an intensity of effort around 30–40% (i.e., 30–40% out of the total feasible repetitions in a set), while allowing long rests between sets . In our study, the increase in SBP during the first set was estimated at an increase of ~7 mmHg per repetition after the forth one, with every new repetition. Additionally, the intersubject variability predicted individual increasing profiles from null to 15 mmHg. In this regard, the development of regression studies will help to anticipate the increase in the pressure response. It will also help stop the set when necessary, in order to reduce the risk of aneurysm rupture. This is when training with continuous designs is needed, such as for eliciting a hypotensive effect . On the other hand, while it seems that IRD might be the best option, when the aim of the resistance training session is to guarantee the electrical integrity of the heart , it may not be the best option when trying to maintain the lowest pressure response possible during the exercise. In this particular case, a set that ends around the nadir of the v-shape response would be the predilected option.