Previous studies (17) have revealed that VPS13C expression in human islets is associated with HbA1c levels by massive parallel sequencing (RNA-seq) and microarray analysis at both nominal and permutation P values (P < 0.05), with lower mRNA levels observed in T2D subjects. We extend these findings here by showing that VPS13C mRNA levels were lower in carriers of risk alleles at rs4502156 and rs7163757 in female, but not male subjects. We note that in the present study a lower number of male vs. female samples may have limited our power to detect changes in the former. However, and arguing against this possibility, no tendency toward lowered VPS13C or C2CD4A expression with the interrogated SNPs was observed in males: rather, the trend was toward increased expression with risk alleles.