Cumulative experimental evidence supports the notion that MV itself, especially if adverse settings including large VT are applied, could be harmful in the context of bacterial pneumonia by promoting pulmonary and systemic inflammation [17, 21, 22]. In the present study, we showed that although LNZ therapy was successful in SB rabbits, its efficacy was limited to the lung compartment in MV rabbits. Interestingly, our findings in our model of pneumococci pneumonia treated with moxifloxacin were similar . No significant histological findings were likely to account for such a difference in extra-pulmonary bacterial diffusion, but unseen lung damage is not excluded.