Table 1 shows the incidence rates of endophthalmitis after pars plana vitrectomy in 20G and MIVS group. The overall incidence of clinically evident and culture-proven endophthalmitis after vitrectomy was 0.040% (4.0 cases per 10,000 surgeries) and 0.021% (2.1 cases per 10,000 surgeries), respectively. The incidence of clinically evident and culture-proven endophthalmitis after 20G vitrectomy was 0.057% (5.7 cases per 10,000 surgeries) and 0.031% (3.1 cases per 10,000 surgeries), and 0.012% (1.2 case per 10,000 surgeries, P < 0.05) and 0.005% (0.5 cases per 100,000 surgeries, P < 0.05) in the MIVS group, respectively. The rate of culture negative endophthalmitis was 0.019% (1.9/10,000 surgeries), 0.025% (2.5/10,000 surgeries) in 20G and 0.007% (0.7/10,000 surgeries) in the overall, 20G and MIVS group respectively. Fig 1 shows the trend in the rate of post-vitrectomy endophthalmitis for the study period of 1995–2015. Over the last decade the has been there is an indisputable decrease noticed in the rate of endophthalmitis post-vitrectomy; the rate decreasing from 0.082% for the study period of 2003–2006 to 0.01% for the study period of 2011–2015.