Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare and potentially life-threatening idiosyncratic drug reaction. It presents with extensive rash, fever, lymphadenopathy, hematologic abnormalities (eosinophilia and/or atypical lymphocytosis) and internal organ involvement. The incidence of this syndrome ranges from 1/1,000 to 1/10,000 after drug exposure. Adults are more commonly affected than children . Approximately 50 drugs (sulfa derivates, antidepressants, nonsteroidal anti-inflammatory drugs) may induce DRESS syndrome, but it is most commonly induced by anticonvulsants (phenytoin, phenobarbital, carbamazepine) and antibiotics . It has been described in association with more than 50 drugs. To the best of our knowledge neither cefotaxime nor clindamycin have been previously reported to cause DRESS syndrome in children. Clindamycin was reported only in adults as an agent causing DRESS syndrome in the literature . We present a child with DRESS syndrome presenting 21 days after starting cefotaxime and clindamycin treatment.