To obtain a size distribution of particles ranging from 1 nm to 1 μm in size, dynamic light scattering (DLS) was used. Particles in a solution move randomly by Brownian motion and scatter light. By analyzing the fluctuations in the intensity of the scattered light as a function of time, the diffusion coefficient of the particles and consequently their size can be calculated. The hydrodynamic diameter of RM 8671 lots was evaluated according to the optimized protocol described previously . Table S14 (see ESM) shows the mean hydrodynamic diameters of the samples from the three lots, which ranged from 9.83 nm to 9.96 nm.