Pharmacogenetic studies have identified genetic associations between the human leukocyte antigen (HLA) allele and AEDs-induced CADR. According to specific AEDs medication, AEDs-induced SJS/TEN has been associated with specific HLA alleles in various populations, namely HLA-B∗15:02 and CBZ in the Han Chinese and Thai populations (Chung et al., 2004; Lim et al., 2008; Locharernkul et al., 2008; Tassaneeyakul et al., 2010) but not in the Japanese (Kaniwa et al., 2008) and European population (Alfirevic et al., 2006), HLA-B∗15:02 and OXC in Chinese and Thai populations (Chen et al., 2017). LTG is the most common AED used in Thailand. It has a similar chemical structure to CBZ, and high cross-reactivity rates of skin reaction from the group of AEDs in Han Chinese epilepsy patients have been reported (Greenwood, 2000; Maggs et al., 2000; Wang et al., 2010). LTG-induced SJS/TEN has been associated with HLA-B∗44:03 in Korean patients but no association was found with HLA-B∗15:02 (An et al., 2010; Hung et al., 2010; Shi et al., 2011; Park et al., 2015). In addition, HLA-A∗30:01 and HLA-B∗13:02 have been associated with a higher risk of LTG-induced MPE in Han Chinese (Li et al., 2013). However, there are no specific HLA alleles associated with LTG-induced CADR and an association between LTG-induced CADR and HLA alleles in Thailand has not been identified. Therefore, we aimed to examine the association between HLA-A and HLA-B and LTG-induced CADR in the Thai population.