The standard protocol of YASARA Structure v. 17.6.5  was used to build the homology models of CsMRP4. To obtain these models, PSI-BLAST  was carried out against PDB entries (updated August, 2017) . After building the homology models for each template, the models were submitted to high-resolution energy minimization using a YASARA force field . The result was then validated to ensure that the refinement did not move the model in the wrong direction. Finally, a hybrid homology model was obtained by combining the best scoring parts of the four models. In addition, potential errors in the 3D models were evaluated using a Ramachandran plot  and ERRAT .