The analysis of GPx1 rs1800668 genotype distribution pointed out that the C wild-type allele had a higher prevalence than the T mutated allele among the recruited water polo players (0.54 versus 0.46). The CT heterozygous genotype was the most frequent, being present in 50% (n = 14) of the studied population. As a whole, people bearing the T mutated allele accounted for over 70% of recruited water polo players, being also present in homozygous state in 21.4% (n = 6) of the study cohort. Wild-type subjects represented 28.6% (n = 8) of the study subjects.