Our analysis of more than 5,000 participants of 55 years and older, revealed two multimorbidity patterns which were clinically recognizable and theoretically plausible. These two identified patterns affected both HRQoL, notably a strong association was found between a multimorbidity pattern related to mental illness and deteriorated bone health (pattern A)–and a decrease in physical and mental HRQoL. The multimorbidity pattern related to cardiovascular and metabolic disorders (pattern B) seems to have no impact on mental HRQoL. The strength of theses associations differed according to age groups.