TMZ, on the other hand, was tested to be non-inferior to RT in elderly patients with a methylated MGMT-promotor in the NOA-08-Trial: The efficacy of RT did not depend on the MGMT-status of the treated high grade gliomas. Also this trial did not test radiochemotherapy in elderly patients . This gap recently was closed by prospective data from an international phase III trial. By comparing hypofractionated RT with concomitant TMZ followed by up to 6 adjuvant cycles of TMZ, the authors demonstrated a significant advantage accompanied by a tolerable toxicity profile also for elderly patients treated with the combined regimen, independently from age and using a very inclusive paradigm .