Im neurons strongly expresses enkephalin202133 that could act at pre- or postsynaptic sites. For example, the glutamatergic synaptic input from the BLA could be targeted by endogenously released opioids, as BLA pyramidal neurons express both MOR and DOR2134. Further, in other subdivisions of the amygdala, at least 60% of MOR is found in postsynaptic dendritic compartments, rather than in axons or terminals, suggesting potential for postsynaptic regulation3435. To date, endogenously released opioids have not been shown to directly activate a postsynaptic conductance in any brain region. However, given Im neurons express high levels of MOR21 and exogenously applied MOR agonists activate a potassium conductance in Im neurons (Im referred to as medial ventral ITC in this study)16 it is feasible Im neurons may be postsynaptically regulated by endogenously released opioids.