The SOD1G93A mouse model has been used since 1994 for preclinical testing of treatments for ALS (Gurney et al, 1994). Here, SOD1G93A mice (on a mixed genetic background) were treated with either P110 or vehicle control, using Alzet osmotic mini‐pumps (delivering 3 mg/kg/day). We began treatment at the age of 90 days, when the clinical/motor symptoms began, to assess the efficacy of P110 treatment in modifying disease progression (Fig 3A). We used activity chamber to determine general activity levels, gross locomotor activity, and exploration habits in rodents (Tatem et al, 2014), and all the following studies were carried out by an observer blinded to the experimental conditions. Changes in mouse locomotor behavior were determined 10 days and 24 days after the initiation of P110 treatment (Figs 3B and C, and EV4). Relative to control‐treated SOD1G93A mice, P110‐treated SOD1G93A mice spent significantly more time exploring the chamber as well as travelled further distance (Fig 3B lower panel vs. middle panel), as measured by ambulatory distance, ambulatory episodes and time spent exploring (Figs 3C and EV4), indicating better motor functions at both time points; their motor behavior was almost indistinguishable from that of WT mice. The exploratory behavior correlated with decreased inactive time (Figs 3C and EV4). We also observed better hind/front grip strength, a tendency toward increased jumping, a behavior associated with intense motor function, and increased locomotion (measured by center zone entries) in the P110‐treated mice relative to control SOD1G93A mice, but no significant increase in body weight after 24 days of treatment (Figs 3C and EV4). Stereotypic counts are the number of times the mouse breaks the same beam in succession, without breaking an adjacent beam. We observed that P110 increases this measure, which is often associated with worsened pathology, but this could be attributed to increased movement and locomotion, as this behavior in SOD G93A mice treated with P110 was comparable to that observed in WT littermates (Fig EV4).