AICAR does not alter development of SS hypertension. (A) Blood pressure recordings collected from vehicle- or AICAR-treated Dahl SS rats during development of hypertension on an 8% NaCl diet (n = 6 and 5, respectively). Effect of AICAR treatment on the blood glucose level (B), proteinuria (C), sodium (D), and potassium (E) excretion in Dahl SS rats fed an 8% diet. No significant differences between vehicle and AICAR-treated rats were found on any of the parameters tested.