From a surgical standpoint, AHO imaging may help guide and customize MIGS in the individual patient for optimized IOP lowering. However, even with segmental aqueous angiographic information, a common clinical question is whether trabecular MIGS should be targeted to regions of greater flow to take advantage of known AHO pathways. The downside is that if flow is good, potential improvement there may be limited. Alternatively, should surgery be performed where flow is bad with the hopes of recruiting additional and increased AHO? This would be analogous to surgically improved AHO uniformity. The potential disadvantage is that maybe flow in initially poor regions may have been low because the anatomy didn’t support AHO in the first place. Now, tools for structural and functional assessment are available to ask these questions. Early experiments suggested that regions of initially poor flow could be recruited with TM bypass using a trabecular bypass stent (Huang AS, et al, 2016; AGS: paper presentation PA23).