The current conventional regimen for PCa diagnosis, which includes PSA measurement, is unreliable in the diagnostic grey area of the reference ranges (2-10ng/mL). Hence, identifying biomarkers which tally accurately with disease risk and staging, as well as providing for evidence based treatment, is key in the reduction of PCa burden in men of African descent. Although PCa may be more aggressive in men of African descent , lack of access to care and delay in diagnosis has obfuscated evidence of a biologically more aggressive disease in African descent men. Among speculated causes of aggressive PCa disease in African men, only age [7, 8] and genetic factors [9, 10] are incontrovertible. Men over the age of 40 and men of African descent are at greater risk of developing PCa compared to their Caucasian counterpart. Men of Asian origin have the least risk of developing PCa, albeit their risk has been reported to increase when they migrate to North America . Few aetiologic and risk factors have been suggested to be associated with PCa development. Modifiable risk factors for PCa have been difficult to identify. Obesity, smoking, alcohol consumption, androgens, diet, diabetes mellitus, and hereditary factors, inter alia, have not been consistently associated with PCa etiology . PCa susceptibility gene loci on 1q24-25 (HPC1), 8p22 (MSR1), 1q25 (RNASEL), and 17p11 (ELAC2) have been recognized by genome wide association studies (GWAS) [12, 13]. Some biological pathways that have been enriched for genetic variants in PCa GWAS were JAK2, IGF-1, prolactin, and androgen signaling pathways . A better understanding of the role of these putative genetic markers is needed among African men with PCa.