Previous studies reported a lower SLC5A5 expression in cases harboring BRAFV600E, and there is experimental evidence showing that BRAFV600E can impair SLC5A5 expression (1, 19, 27, 39), nevertheless the impact of other relevant mutations found in thyroid tumors on SLC5A5 expression remained unknown. In our series, SLC5A5 expression was lower but did not reach statistical significance in the BRAFV600E PTC compared to that of BRAF wild-type group. The lack of significance in our series may be due to differences in size and composition of the series, since the above mentioned studies addressing SLC5A5 expression and BRAF V600E (1, 19, 27, 39) used larger series of PTC.