Then we considered the activation of voltage-dependent currents in the dendrites (Anwar et al., 2014) by delivering the appropriate multisynaptic stimulation pattern to the PC model in pacemaking regime. The higher synaptic depolarization in sector II than in sector I resulted in a stronger voltage-dependent activation of Ca channels in the former than in the latter (Figure 7B). In sector II, LVA currents amplified the EPSPs leading membrane potential to raise enough to activate also the HVA currents, thus causing a regenerative calcium spike. Consequently, a large raise in intracellular calcium activated the KCa system. This effect eventually influenced the spike-generating mechanisms in the AIS and regulated the pause, that was longer in sector II than sector I.