Clonorchis sinensis, a human liver fluke, is a major food-borne parasite in China . Long-term infections can lead to liver fibrosis, cirrhosis and even carcinogenesis [2, 3]. Some epidemiological studies and clinical researchers have shown that the incidence rate of primary hepatocellular carcinoma (HCC) is much higher in patients infected with C. sinensis than in non-infected patients [4–6].