FD-10M mice also presented decreased hemoglobin levels, packed cell volume and hematocrit values, lower red and white blood cell counts and reduced lymphocyte percentage, together with increased mean corpuscular volume, mean corpuscular hemoglobin and an enhanced degree of anisocytosis (Table 1). Their bone marrow showed a decrease in megakaryocyte number, which also had lower differentiation and volume (Figure 1C). Along with these alterations an increased number of Howell-Jolly bodies, hypersegmented polymorphonuclear neutrophils and strong anisocytosis were observed in peripheral blood extensions of FD-10M mice (Figure 1C). Altogether, these changes indicated signs of megaloblastic anemia that jointly with the presence of signs of stress in the FD-10M mice, led to the interruption of our study at 10M, despite the late-onset of HL described for these mice.