Historically, natural products have inspired the development of many pharmaceuticals and agrochemicals, which, have in turn, played an important role in improving human and animal health and agricultural productivity, enhancing the quality of life for communities across the globe . One of the defining characteristics of natural products is their structure diversity, which can encompass complex carbocyclic and heterocyclic scaffolds, annotated with a wide array of functional groups and stereochemical features. As such, even a limited set of biosynthetic precursors can deliver remarkable chemical diversity. Illustrative of this phenomenon are bromophenols from marine red algae (Rhodophyta) . For example, the red alga Symphyocladia latiuscula (Harvey) Yamada has been reported to produce a diverse array of bromophenols elaborated by sulfoxides, sulphones, sulfates, glutamines, pyrrolidin-2-ones, ureas, diketopiperazines, and aconitic acids, with biological properties spanning antibacterial , antifungal , antiviral , anticancer , free radical scavenging , aldose reductase inhibitory , and Taq DNA polymerase inhibitory activities . S. latiuscula bromophenols typically contain at least one 2,3,6-tribromo-4,5-dihydroxybenzyl moiety, as consistent with a highly conserved biosynthetic pathway. This report described our efforts to further elaborate the chemical diversity of S. latiuscula.