Antibodies used in the study are listed in Supplementary Table S1. All antibodies were used at dilutions optimized in our laboratory. For immunoblot analysis, 10 μg protein samples were separated on a sodium dodecyl sulfate–polyacrylamide gel electrophoresis and transferred onto Immobilon-P PVDF membrane (EMD Millipore, Billerica, MA, USA). The membrane was incubated for 1 h in blocking buffer (Tris-buffered saline, 0.1% Tween (TBS-T), 5% nonfat dry milk), followed by incubation overnight at 4 °C with the primary antibody. After a wash with TBS-T, the blot was incubated with horseradish peroxidase-conjugated secondary antibody and signals were visualized by Luminata Crescendo chemiluminescence western blotting substrate as per the manufacturer's protocol (EMD Millipore).