In this study, a significant number of culture-negative cases could be effectively managed with intravitreal antibiotic injections with relatively better visual and anatomical outcomes. Because the genomic bacterial load predicts severity and outcomes, it is possible that a lower bacterial load favored better outcomes and corresponding inability to capture the microbe on culture. This seems most probable as 75% culture-positive patients presented within 1 week of surgery, in contrast to 66.7% culture-negative patients, owing to this difference in genomic bacterial load.