In platelet rich plasma from healthy subjects the P2Y12R antagonist cangrelor reduced the production of ADP-stimulated vascular endothelial growth factor (VEGF) (Bambace et al., 2010) a key protein in angiogenesis. Moreover, platelet secretion of other proangiogenic molecules, including IL-1α, IL-1β, GM- CSF, MMP-1 and uPAR, can be controlled by P2Y12R inhibitors in non-small cell lung cancer cell-stimulated platelets (Wu et al., 2015).