Current cytogenetic analyses are based on DNA and RNA and consist of karyotyping analyses, fluorescence in situ hybridization (FISH), quantitative real-time polymerase chain reaction (RT-PCR), microarray-based comparative genomic hybridization (array CGH) and more recently next-generation sequencing (NGS) . Those techniques enable the detection of chromosomal abnormalities including translocations, recurrent fusion genes, internal chromosomal amplification, and loss or gain of chromosomal region. Those routine techniques used for the clinical diagnosis such as FISH, array CGH or NGS can be laborious, time-consuming and expensive and therefore may be not available or applicable in all research laboratories.