T-test was employed to analyze differences in each two-group comparison and one-way ANOVA was performed to determine the difference among at least three groups. Kaplan–Meier analysis was used to assess the survival rate of mice. Heat maps were performed with Gene Cluster 3.0 and Gene Tree View software. Kaplan–Meier analysis was used to assess the survival rate of patients and mice. KEGG pathway and GO analysis were performed via DAVID (http://david.abcc.ncifcrf.gov/). P < 0.05 was considered statistically significant.