QikProp, the package in Schrodinger is used for calculating molecular descriptors in predicting ADMET properties . The following parameters are considered here with their ranges given specifically; Polar Surface Area (PSA) that is related to oral bioavailability with the area less than 140A2; Rule of Five indicating the molecules suitability for oral administration; QPlog BB- Blood Brain Barrier that provides an access for the central nervous system with a range lies between -3.0 to 1.0; QPlogPo/w that calculates the hydrophobicity of the molecule with a range of 2.0-6.5; QPlogHERG, the experimental IC50 value for HERG K+ channel blockage, with a range below -5.0; QPPCaco and QPPMDCK, the respective cell permeabilities with a value of >500 nm/sec .