Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were used to measure the association between these two polymorphisms and BC risk among five genetic models: an allele contrast genetic model, a homozygote genetic model, a heterozygote genetic model, a dominant genetic model, and a recessive genetic model. Heterogeneity among studies was evaluated by I2 test and Q test. For I2 test, the criteria for heterogeneity were as follows: I2 < 25%, no heterogeneity; 25%-75%, moderate heterogeneity; I2 > 75%, high heterogeneity. If the P value of the Q test was < 0.1, the random-effects model was used; if not, we would select the fixed-effects model to carry out our research. Sensitivity analysis was performed by deleting one study at a time. To evaluate the publication bias, we used Begg's test, Egger's test and funnel plot. Subgroup analysis was performed according to ethnicity and sources of controls. The P value for Hardy-Weinberg equilibrium (HWE) was calculated by the chi-square test in the control group in each study. All statistical analyses were performed using STATA version 10.0 software (Stata Corp LP, College Station, TX, USA). All P values were two sided, and P < 0.05 was considered statistically significant.