We appreciate the reviewer’s comments, and agree that a stable CMG-Mcm10 complex is suggestive that Mcm10 always travels with the replisome. But the available cellular studies that address whether Mcm10 travels with the replisome are not settled in the literature, with reports and data going in both directions. Since we have not shown the persistence of Mcm10 (i.e. koff rate) with CMG at a fork, we discuss the possibility that CMG might travel with the fork all the time in the Discussion, as requested, but we also note that we cannot rigorously make that conclusion from the data of the current report.