Mean plasma concentration–time curve of 5-FU for the entire population. 5-FU: fluorouracil, AUC0-24h: areas under the curve, Cmax: maximum concentration, Tmax: time taken to reach maximum concentration, T1/2: half-time, AUMC0-24h: area under the first moment curve, MRT0-24h: mean resistance time, CL: plasma clearance (TIFF 163 kb)