As depression is a very common comorbidity in RLS and many antidepressants such as selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs) can worsen the symptoms of RLS, treatment of depression in RLS patients should be cautious. Since bupropion, a newer antidepressant, doesn’t show any evidence of exacerbation of RLS symptoms, it is used as an effective antidepressant in these patients (Mackie and Winkelman, 2015).