Microwave plasma torch (MPT) has been used as the excitation source for atomic emission spectrophotometry (AES) for decades. Traditionally, the capability of MPT to produce ions has not been considered in AES. In fact, MPT combines many merits such as relatively high temperature, high electron density, and high positive charge density . These make MPT a suitable ionization source for desorption ionization of solid samples. Recently, protonated analytes in liquid samples were also produced by MPT . Theoretically, the high temperature of MPT allows the observation of ambient thermal dissociation of the analyte ions produced by MPT sources. In such a case, the total amount of the energy transferred to the analyte ion can be manipulated by changing the experimental conditions and, thus, the extent of fragmentation can be tuned without applying collision-induced dissociation (CID) experiments. Obviously, it is highly desirable to couple MPT with a simple mass spectrometer for rapid qualitative analysis of real-world samples. In this work, a novel, facile strategy is proposed to tune the mass spectral pattern by combining desorption and ionization process in a miniaturized MPT source. Because fast screening counterfeit drugs is of sustainable interest, MPTDI-MS was applied to rapid detection of ions of the active ingredients in drug preparations. The results showed installation of MPTDI-MS is cost-effective in potential screening of counterfeit drugs.