IL-10 as an anti-inflammatory cytokine has a role in the initial immune response which is mediated by B cell. Cytokine IL-10 is involved in the decrease of the inflammatory response . IL-10 inhibits the synthesis of IFN-c, IL-1, IL-6, IL-8 and TNF-α, and also acts as a feedback mechanism in reducing these cytokines [13, 14]. IL-10 might contribute to the failure of the immune response to clear H. pylori infection, and in a previous study we found the increased secretion of IL-10 in biopsy specimens in H. pylori infection, with the secretion of the cytokine correlating with the degree of chronic inflammation. Yamaoka et al have reported increased expression of IL-10 mRNA in biopsies from infected patients .