(A) Schematic representation of the predicted and functional miR-128 binding sites in long-interspaced element-1 (LINE-1, L1) CDS RNA compared to two predicted miR-128 binding sites in the CDS of TERT mRNA. (B) Schematic representation of the two putative non-perfect 7-mer miR-128 binding sites in the coding sequence of TERT mRNA. (C) Relative luciferase levels of HeLa cell transfected with constructs expressing either TERT binding sequences at site #1 or site #2 or a perfect miR-128 seed match (perfect seed) (Wildtype (WT) seed plasmids), along with miR-control (Control) or miR-128 (miR-128) mimics, measured 48 hours post transfection. Results shown as percent change ± SEM (n = 3 independent experiments, *p < 0.05, **p < 0.01, ****p < 0.0001) (D) Relative luciferase levels of HeLa cell transfected with constructs expressing the wildtype (WT seed plasmid) or mutated (Mutated seed plasmid) 7-mer TERT binding sequences, along with miR-control (Control) or miR-128 (miR-128) mimics, measured 48 hours post transfection. Results shown as percent change ± SEM (n = 3 independent experiments, **p < 0.01).