Between November 2012 and August 2014, HIV-1 serodiscordant couples were recruited for the Partners Demonstration Project from HIV-1 voluntary counseling and testing (VCT) centers, HIV-1 care providers, programs for prevention of mother-to-child HIV-1 transmission (PMTCT) services, and community promotion activities for couples’ VCT. Enrollment was completed in August 2014. At the screening visit, demographic and behavioral information were collected via interviewer-administered standardized questionnaires. Screening laboratory tests included repeat HIV-1 testing for both partners following the national HIV-1 testing algorithms, serum creatinine and hepatitis B surface antigen (HBsAg) for HIV-1 uninfected partners, and CD4 count and plasma HIV-1 RNA concentrations for HIV-1 infected partners.