Genes required for cytosolic survival differentially activate the inflammasome. Lactate dehydrogenase assays were performed by infecting wild-type (WT) or caspase-1- and caspase-11-deficient (Casp-1 and Casp-11−/−) BMDMs with L. monocytogenes bacteriolysis mutants (MOI of 1). Data are presented as means ± SEM of results from three independent experiments. LDH, lactate dehydrogenase.