OEC‐CM exhibits neuroprotective effects on the human neuroblastoma cell lines. (A) Experimental plan. (B–G) xCELLigence system E‐Plate analysis of cell viability on SH‐SY5Y cell cultures. Each dot represents the CI mean (±SEM) of three independent analyses and CI was revealed every 30 min on the same cultures. (H–K) Rate of Cell Growth (slope of the line between time 0 and time 24) in normoxic and hypoxic SH‐SY5Y (H, I) and SK‐N‐SH (J,K) cell cultures exposed to different conditioning‐time and percentage of OEC‐CM.**P < 0.01 versus CTRL. ***P < 0.001 versus CTRL. ##P < 0.01 versus corresponding OEC‐CM 25%. ###P < 0.001 versus corresponding OEC‐CM 25%. §P < 0.05 versus OEC‐CM 72 hr 100%. §§P < 0.01 versus OEC‐CM 72 hr 100%. §§§P < 0.001 versus OEC‐CM 72 hr 100%. (manovas and Tukey honest significant difference (HSD) post hoc test).