Sbp1 is an RNA-binding protein that was initially discovered to coimmunoprecipitate with small nucleolar RNA 10 and 11 (snoRNA10 and snoRNA11) in yeast (Jong and Campbell 1986; Jong et al. 1987; Clark et al. 1990). In addition to its localization in the nucleolus (Jong et al. 1987; Clark et al. 1990), Sbp1 was shown to localize in processing bodies (P bodies) under the stress of glucose starvation in yeast (Segal et al. 2006). Overexpression of Sbp1 results in global translational repression and an increase in the size as well as number of P bodies (Segal et al. 2006). In the same study, Sbp1 was shown to promote decapping of a reporter mRNA with another protein, Dhh1.