We plotted a scatter diagram (Figure 4) of the cumulative occurrences of these ligands interacting with the residues of HER2 (plotted against the sequence number of HER2). The resultant plot clearly indicates that there are five different clusters in HER2 that are so closer to one among them spatially, in the folded form, thus forming the pocket of interaction. The clusters are colored differently so as to differentiate them on the structure. These clusters are distributed among the three domains: Nterminal Domain, middle elongated domain and the third helical domain. The N-terminal domain consists of first three of the clusters (residues T5, G6, T7 and D8; residues Q35, G36, N37 and G38; residues T83 and Q84); middle domain has the cluster 4 (residues T290, L291 and V292), and the helical domain 3 has the helical cluster (residues G411, R412, I413, L414, H415, N416 and G417). It has been observed that the domain 1 consists majorly of polar residues and domain 2 is observed with hydrophobic residues. The helical domain 3 has both hydrophobic and hydrophilic residues and the helical wheel plot segregates both the groups for specific interactions.