In conclusion, for glaucoma, creating posterior segment structure: function relationships have been underway and are already quite developed [41–43]. In the anterior segment, a separate relationship is lacking and needs to be had. Modern tools, including anterior segment OCT and aqueous angiography, will likely play a role in creating that anterior segment structure: function understanding. Clinical relevance may come in the form of developing new pharmacological tools using structural or functional endpoints or improving surgical results from custom-targeted surgical approaches.