The three lots of RM 8671 were found to conform to previously observed results for PS 8670 for all size parameters measured to within the ±3uc control range listed in ESM Table S8. The one-way two-tailed ANOVA, however, did reveal a minor (nearly negligible, <0.03%) difference from PS 8670 in the glycan occupancy. This difference may be attributable to expected minor variations in the cellular expression/production of batches of material used for PS 8670 versus RM 8671.