The performance of the adherence IVR was evaluated in vitro by exposing the devices to controlled temperatures simulating insertion and removal events. Devices were placed in a small aluminum enclosure with a flexible silicone heater (Watlow, St. Louis, MO, USA) and solid-state temperature controller (CT325, Minco, Minneapolis, MN, USA) providing accurate (±0.2°C) temperature control. The time, controller temperature set-point, and measured temperature were logged using a PC-based data acquisition system (National Instruments USB-6002 DAQ, Austin, TX, USA) using software written in the LabView development environment (National Instruments). For experiments spanning multiple days, the enclosure temperature was cycled between an “IN” state (~37°C) and “OUT” state (ambient, ~25°C) at predetermined intervals to simulate a sequence of IVR insertions and removals.