MsrA has longevity benefits in different organisms. As a substrate of the peroxidase activity of MsrA, DMS may exert longevity benefits. In Drosophila, the lipid oxidation product MDA decreased significantly with the treatment of DMS (10 μm) in aged Drosophila from 15.2 ± 0.5 nmol mg−1 protein to 11.3 ± 0.6 nmol mg−1 protein (Fig. 3A, P < 0.01). We further tested whether DMS exerted lifespan‐extending properties in Drosophila. The mean survival time of control group was 48.25 ± 0.91 day. Meanwhile, the mean survival time was extended to 54.80 ± 1.06 day (10 μm), 59.95 ± 1.11 day (100 μm), and 55.99 ± 0.58 day (1000 μm) with DMS exposure (Fig. 3B, P < 0.01). However, DMS did not prolong the lifespan of Drosophila at low concentrations (1, 2, or 5 μm, Fig. S5).