Recent literature supports the relationships inferred between clinical pathologies for habitats (Table 4) and pathway alterations (Table 3). For instance, it is reported that that overexpression of inflammatory cytokines is linked with the leading edge of the gliomas. This is consistent with our findings (positive association of cytokine production) in habitat 2, which is associated with the leading edge of the tumor . Furthermore, it is well known that glioblastoma is infiltrated by diverse immune cells including macrophages , which might explain the positive association of macrophage activation and habitat 7. It is also reported that potassium channel inhibitor activity plays a critical role in cell proliferation and cell swelling in neuroblastoma and gliomas . Further, Sforna et al.  reported that calcium ions channels play a role in swelling in GBM. These reports are consistent with our clinical pathology interpretation, edema, for habitat 10.