The impact of cortical input patterns, conveyed through pf, granule cell aa and stellate cells (SC), on PC spike firing was investigated using detailed PC models differentiated into Z+ and Z− types (Masoli et al., 2015). These models differ for the expression of depolarizing TRPC-like channels in the terminal dendrites, resulting in higher background SS activity in Z− than Z+ PCs (around 90 Hz vs. 45 Hz). Both models were endowed with excitatory and inhibitory synapses, which were located according to anatomical measurements. This, combined with the filtering properties of dendrites, caused the expected EPSP electrotonic decay from synapses to soma (Roth and Häusser, 2001). The synaptic models were endowed with dynamic mechanisms (Tsodyks and Markram, 1997; Nieus et al., 2006, 2014; Figures 1A,B) allowing to adapt neurotransmission to arbitrary spike patterns (Dittman et al., 2000; Figure 1C).