In sub-Saharan Africa, heterosexual HIV-1 serodiscordant couples account for a substantial proportion of new HIV-1 infections [1–3]. Randomized clinical trials have provided definitive evidence that antiretroviral treatment (ART) for HIV-1 infected persons  and pre-exposure prophylaxis (PrEP) for HIV-1 uninfected persons are highly efficacious in decreasing HIV-1 transmission risk within HIV-1 serodiscordant partnerships . Mathematical modeling studies have found that providing HIV-1 serodiscordant couples with antiretroviral prevention interventions may have a significant impact on the HIV-1 epidemic . Delivery of antiretroviral based HIV-1 prevention interventions, particularly in resource-constrained settings, must target those at highest risk for HIV-1, which would achieve maximal public health benefit in a cost-effective manner [7–9].