In addition, recently, the boost of tamoxifen intestinal permeation after encapsulation in chitosan/lecithin nanoparticles and in presence of specific enzymes such as lysozyme and lipases has been highlighted . Lysozyme in particular is an antibacterial protein found in many physiological secretions, able to degrade chitosan and hence to biodegrade the chitosan/lecithin nanoparticle structure. Interestingly, lysozyme is among skin-produced antimicrobial peptides, and pilosebaceous follicle cells, hair bulb cells and eccrine sweat glands have been found to be positive for lysozyme . This suggests that nanoparticle accumulation in the skin annexes could contribute to explain the outstanding performance of the nanoparticle formulation containing clobetasol propionate in two ways: By forming a reservoir of the drug;Through a progressive enzyme-controlled delivery of the drug from the nanometric delivery system.