The properties of various extracts of the fruit of the Terminalia chebula tree have been widely investigated and include anti-diabetic, anti-mutagenic, anti-oxidant, anti-bacterial, anti-fungal, and anti-viral effects . Many of these beneficial effects are related to the presence of various phytochemicals including polyphenols, terpenes, anthocyanins, flavonoids, alkaloids, and glycosides . In the present study, we determined the effects of an ethanol extract of T. chebula (EETC) in preventing DPB-induced inflammation and bone resorption, and identified the principal molecules in this inflammatory response that are regulated by EETC. The data indicate the potential value of EETC in preventing DPB-mediated periodontal disease.