(a) TD dynamics, (b) Iα dynamics, (c) I6 dynamics, and (d) I17 dynamics. In silico knockouts of M1 (red dashed line), DC (red circles), Th1 (black stars), Th17 (black plus), CD8+T (black squares), TNF-α (blue dash-and-dot line), INF-γ (black asterisk), IL-6 (blue triangles), and IL-17 (black cross) [wild type is denoted by WT (black solid line)].