Our analysis reveals that the intratumoral abundance of these habitats are associated with outcome. Delineating the extent and location of these aggressive habitats can have implications for delivery of radiotherapy (boosting RT to aggressive habitat areas), surgical resection (an aggressive habitat not impinging on an eloquent area is amenable for possibly complete resection). Additionally, tracking/monitoring the growth of aggressive habitat subvolumes can provide a deeper understanding of disease evolution/recurrence instead of just gross tumor volume. The utility of defining heterogeneity in glioblastoma thus is closely related with prognosis and overall survival of patients [1–4]. Hence, defining such phenotypic heterogeneity is directly relevant for treatment planning, surgical intervention, disease monitoring, and prognosis estimation in the clinic.