Comparisons between those with and without major bleeding were performed by t-test for continuous data and by Fisher’s exact test for binary data. Categorical data comparisons with greater than 2×2 dimensions were performed by the Freeman-Halton exact test. Univariate analyses were performed for various baseline and treatment characteristics to assess their relationship with major bleeding status. Co-morbid conditions that could complicate the use of fibrinolytic therapy and had a univariate p<0.10 were included in the multivariate logistic regression model as potential predictors for bleeding. These included recent major surgery, cerebrovascular disease, recent gastrointestinal or genitourinary bleeding, and recent trauma. Aside from the multivariate logistic regression analyses, no adjustments for multiple comparisons were made. All analyses were performed using SAS® software version 9.2 (SAS Institute, Cary, NC, USA).