To combat increasingly complex public health threats, public health leaders should pursue new processes and implement innovative solutions. In particular, traditional public health planning models do not explicitly encourage innovation. While the private sector conventionally resorts to innovative thinking, experimentation, and risk-taking in the face of threats, this approach is not yet embraced in public health’s program planning models. A new public health framework, which incorporates successful processes of the private sector and maximizes the strengths of the public sector, may be a major key to significant improvements in our most pressing and complex public health threats.