Specifier for clinical significance of RLS emphasizes that the influence of RLS on the patient’s function in social, occupational, educational, or other important areas should be evaluated. Different from in adults, functional consequences of RLS in children are mainly behavioral and educational domains (Arbuckle et al., 2010). The new diagnostic criteria set up a more rigorous method to ascertain a RLS case with more specific criteria and excluding standards. It has improved the validity of RLS diagnosis. On the other hand, it helps to classify the patient’s clinical course and clinical significance which helps the physician to better monitor the progression of RLS and support better cases for research samples (Allen et al., 2014). The specifier for clinical course does not apply for pediatric RLS or special cases of RLS secondary to pregnancy or medication (Picchietti et al., 2013). Generally, mild RLS severity with no family history, and young age at RLS onset are predictors of RLS remission. While most patients with severe RLS show a chronic clinical course (Lee et al., 2016).