LJM and QG conceived and performed most of the experiments. LJM, MD, and ZCW developed the methodology. QG, LZL, AWK, LQD, JYS, XMZ, and YC provided facilities and acquired and managed patients. LJM, QG, and MD analyzed and interpreted data. QG, LJM, XYW, and MD wrote and reviewed the manuscript. LJM, ZBD, LXY, JZ, and JF organized data and constructed databases. QG and XYW supervised the study.