Gemzar (gemcitabine) single-agent chemotherapy is the standard treatment for metastatic or locally advanced pancreatic cancer, but it has a modest survival benefit . FOLFIRINOX, a combination of chemotherapeutic agents (folinic acid, fluorouracil, irinotecan, and oxaliplatin), was recently shown to nearly double the median survival of pancreatic ductal adenocarcinoma (PDAC) patients compared to gemcitabine (11.1 vs. 6.8 months). However, patients must be carefully selected and managed because of toxicity . Nab-paclitaxel (NPT) is a water-soluble, cremophor-free, albumin-bound formulation of paclitaxel. It was initially developed to circumvent the toxicity associated with cremophor, which is required to solubilize paclitaxel. NPT in combination with gemcitabine resulted in a median survival time of 8.5 months compared to 6.7 months after gemcitabine treatment alone [8–9]. Given the moderate improvements in PDAC patient prognosis, there is an urgent requirement for novel therapeutic strategies to improve overall survival.