Very common conditions which should be differentiated with RLS include leg cramps, positional discomfort, local leg injury, arthritis, leg edema, venous stasis, peripheral neuropathy, radiculopathy, habitual foot tapping/leg rocking, anxiety, myalgia, and drug-induced akathisia (Allen et al., 2014). They can mimic RLS in different ways. Leg cramps are presented as knot of the muscle. Positional discomfort can be relieved by a positional shift. Arthritis patients have a limitation of the joints or joint erythema. Myalgias present as muscle soreness. Numbness happen to neuropathy patients as well as RLS patients, and both venous stasis and leg edema can manifest as swelling in the limbs (Davis et al., 2005; Applebee et al., 2009; Sinha et al., 2009; Karroum et al., 2012). Less common differential diagnostic conditions included myelopathy, myopathy, vascular or neurogenic claudication, hypotensive akathisia, orthostatic tremor, painful legs, and moving toes (Allen et al., 2014). Differential diagnosis is really important to RLS patients for their further treatment. Therefore clinical physicians have created additional diagnostic questionnaires and scales to improve the diagnosis of RLS in clinical practice (Popat et al., 2010). RLS-NIH questionnaire, developed in 2002 with three mandatory questions, showed sensitivity and specificity of 86 and 45% respectively (Popat et al., 2010). On the basis of this, an the RLS-EXP showed the sensitivity and specificity of 81 and 73% respectively (Popat et al., 2010). The CH-RLSq is more commonly used in clinical practice and by researchers.