GSN displayed high expression in the secondary diffuse large B-cell lymphoma (DLBCL) compared with de novo DLBCL (Ludvigsen et al., 2015). However, a recent study revealed that the level of GSN is downregulated in serums of advanced NKTCL patients (Zhou et al., 2016). Although the roles of GSN have been explored, whether the GSN can modulate cell proliferation, apoptosis and invasion in NK/T-cell lymphoma cells is currently unknown. Further investigations are required concerning the role of GSN in NK/T-cell lymphoma progression to determine whether decreased or increased GSN levels in NK/T-cell lymphoma have a direct relationship with tumorigenesis.