We appreciate the reviewer’s concerns and certainly agree that the GINS are notoriously difficult to stain. We have rerun the gels, but we should also point out that while this project was being performed, Mcm10 was demonstrated in the Bell lab to preferentially bind CMG, containing GINS, Cdc45 and Mcms (Lõoke, et al., 2017). However, we have re-run FLAG and MonoQ experiments and re-run gels to the best we could, and have added those gels and the following text to the manuscript. We also note that Steve Bell’s recent paper on Mcm10 (cited herein) demonstrates that Mcm10 stabilizes the CMG complex.