Our study has several limitations. First, it was a nonrandomized retrospective study with a medium-sized sample. Second, we analyzed only the subgroup of AP patients in the consecutive patient cohort who underwent CT within 24 hours after the onset of symptoms and laboratory examination at the first and third days of admission. Some patients with severe acute pancreatitis were discharged without medical advice, which may have contributed to the absence of hospital mortality in our cohort. Only 208 out of 325 patients (64.0%) were included in our study. This large number of exclusions may have introduced some selection bias, which might explain the low incidence of patients (only 3) with multiple organ failure. Third, we did not evaluate the interobserver variability in the EPIC score; however, the definitive EPIC score was determined by consensus in cases where the CT imaging findings between the 2 radiologists were inconsistent.