In the human genome, less than 2% of the transcripts encode proteins, and the remaining 98%–99% are non-coding RNAs (ncRNAs) .1 ncRNAs can be divided into two categories: short non-coding RNA (short/small ncRNA) and long non-coding RNA (long ncRNA). No particularly stringent boundary exists between these categories, except for the length of the ncRNA nucleotide sequence. An ncRNA of greater than 200 nt is defined as an lncRNA. In recent years, with the rapid development of RNA sequencing technology and computational methods, lncRNA has been gradually recognized by researchers. lncRNA is widely distributed among animals, plants, yeasts, and even viruses, and we now know that lncRNA can be involved in X chromosome silencing, genomic imprinting, chromatin modification, transcriptional activation, transcriptional interference, epigenetic regulation, and other important regulatory processes.2 These molecules are related to cell proliferation and differentiation, metabolism, and other physiological processes, as well as various pathological processes. The mutation and abnormal regulation of lncRNAs plays an important role in many human diseases, such as the occurrence and development of cancer and neurodegenerative diseases.3, 4, 5