LEP G2548A polymorphism, located in the 5’ region of the LEP gene, is implicated in transcription . Several studies have shown that the variants might elevate the serum leptin level through transcriptional level . Snoussi et al.  showed that polymorphisms in LEP gene are associated with increased BC risk as well as disease progress, while no association of rs7799039 polymorphism with the risk of BC was observed by another study . We observed no association between LEP G2548A polymorphism and BC risk in general populations, and similar results could be seen in the stratified analysis by ethnicity and sources of controls. In the meta-analysis by Liu et al. , three studies were included and the result showed that no significant association between rs7799039 polymorphism and BC risk. Nevertheless, Yan et al.  found that the rs7799039 polymorphism plays an important role in BC susceptibility, especially in Caucasians; however, there are some mistakes in her study. First, the study of Vairaktaris et al.  is about the association of leptin G2548A polymorphism with increased risk of oral cancer, but not BC. Second, the data in the study of Teras et al.  did not seem in accordance with the data provided in their original publication. Compared with them, our study includes two new studies, which will expand the sample size and thus get a more precise evaluation.