Dergunov et al. reported on the design of a porous polymeric nanoreactor with a lipid bilayer for coupling reactions . These nanocapsules were loaded with palladium catalysts and successfully used in Suzuki, Sonogashira and Heck cross-coupling reactions. Catalytic activity was compared to the activity of the freshly prepared free catalyst, and the palladium entrapment did not affect either the conversion or the yields of the reaction . The catalyst immobilization also allowed facile Pd removal from the final product and catalyst recycling.