As shown in Table 2, all potential predicative factors mentioned above were summarized by univariate analysis. The results from the univariate logistic regression analysis indicated that age, MCCI, preoperative MMSE score, postoperative cardiovascular events, and CRP concentrations preoperatively or on postoperative day 2 were associated with POD. With these six variables introduced into the final multivariate analysis, the results suggested preoperative CRP concentrations as the independent predicator for POD in patients undergoing laparoscopic surgery for colon carcinoma (OR: 5.87; 95% CI: 2.22–11.4; P = 0.018).