For dose, animals receiving 100-125mg/kg dose had the largest (3.31 SMD, 95% CI, 2.55 to 4.07) and those receiving 150–250 mg/kg the smallest (2.21 SMD, 95% CI, 1.61 to 2.81) reduction in the abundance of SOD (χ2 = 283.09, Τ2 = 1.73, I2 = 78.8%, d.f. = 60, p<0.0005; Fig 4B).