Thus, there was a need for pathogenic gene through artificial screening to further analyze in terms of specific disease phenotype. Detection of the relationship between gene and non-small cell lung cancer conducted in Pubmed, gene name and non-small cell lung cancer as the searched key words, that is (“gene symbol” or “gene”) and “non-small cell lung cancer”. The literature would be recorded if the two key words appeared both in title and abstract of the same literature, as the evidence of detection of the association between gene and non-small cell lung cancer. Finally, 81 pathogenic genes were gained from the literature, specific gene name included in the Supplementary Table 1.