Restless legs syndrome is very common in women during pregnancy and lactation, with a prevalence of 15–25% (Hubner et al., 2013). Guidelines on treating RLS during pregnancy and lactation have been published by IRLSSG in 2014 (Picchietti et al., 2015) (Table 5). Once RLS is diagnosed in pregnancy, non-medicine treatment should be considered firstly. Patients should be educated about the natural course of RLS during pregnancy, in which RLS commonly remits or disappears after delivery. Moderate exercise and avoidance of aggravated factors such as iron deficiency, long-term immobility, serotonergic antidepressants should be suggested. Iron level should be measured to decide whether to treat the patient with iron. Iron therapy (oral or intravenous) should be given when serum ferritin < 75 ug/L. When serum ferritin > 75 ug/L with refractory RLS, drug treatment should be considered.