Electron microscopy analysis of mitochondria in spinal cord from WT mice, SOD1G93A mice, and SOD1G93A mice treated with P110. Scale bar: 0.2 μm. Data are means ± SD of 20 microscopic fields, at least, from three mice per treatment group. Normal mitochondria structure was dramatically reduced and mitochondria with damaged structure increased in SOD1G93A mice. Percent mitochondria with altered structure were quantified and are represented in the graphs. At least 40 mitochondria were analyzed in each group by an observer blinded to the experimental conditions. For mitochondrial number, mtND2 levels were analyzed by real‐time PCR.