In olden days, sponges were soaked with wine and put on the left side for heartaches, and sponges soaked in urine are used for the treatment of bites of poisonous animals. In 18th century, the physicians used sponges in powdered form for lung diseases, which comprise of various types of sponges mixed together and powdered. The sponge Spongia officinalis is used as syrup for dry and asthmatic cough in western parts of the world. Manoalide, the sesterterpenoids isolated from marine sponge Luffariella variabilis , is found to be an antibiotic and analgesic. There are around 5300 different products discovered from sponges. The ability to stimulate the production of secondary metabolites by sponges is an important consideration when one wants to harvest compounds from sponges for the production of potential novel therapeutics. The molecular mode of action is not thoroughly investigated, whereas the mechanism by which the sponges interfere with compounds have been reported , through which the bioactive compounds can be transformed into new medicines.