Several studies have correlated specific features seen in MRI of GBM with patient survival and molecular subtype. However, these investigations have been restricted to 1 or 2 particular MRI sequences and typically considered only features from a single 2D slice [12, 16, 17]. In contrast to these single-sequence, slice-by-slice analyses, radiologists review all acquired MRI sequences in their assessments. Additional research is needed to develop methods for extracting computational radiological features from full multiparametric MR imaging sets. To this end, this study focuses on using four MR sequences to understand the heterogeneity of a tumor region.