Our data underline the role of an intensive early treatment as well as of salvage treatments for older patients. Especially patients treated with standard-fractionated RChT as well as adjuvant chemotherapy had a median OS that was similar to younger patients. This is in-line with the conclusion from a SEER-based analysis from 2015 . Reasons for this might be the good physical status of patients within this cohort as well as the high amount of patients with methylated MGMT promotors. As the performance score but not age significantly related to the treatment decision and to the outcome, monotherapy should only be considered for patients older than >70 years and presenting with a lower performance score. This algorithm is also in line with the resent guidelines for the treatment of GBM from the American Society of Clinical Oncology (ASCO) . Notably, when reviewing earlier studies or studies from other geographic areas, the huge geographic differences of life expectancies have to be taken into account. Exemplarily, the life expectancy within the western world approximately increases every 20 years by 5 years, currently reaching an average life expectancy of 80 years, compared to an average life expectancy of 66 years in India.