Relative to the online tool bitterX (Huang et al., 2016), e-Bitter works on the local machines, which ensures that users can well exploit their own computational resource to test their propriety compounds without turning to the external web server. Moreover, e-Bitter can screen the small-molecule database in batch. More importantly, e-Bitter program adopts the consensus voting strategy based on the multiple machine-learning algorithms to enhance the reliability of prediction result.