This study is the first report of increased venous return due to exercise by the contralateral hand without any influence of the systemic circulation. As peripheral venous return is to the heart, it is recognized in two main factors: the muscle pump and the respiratory pump. In the present study, we speculated on the possibility of a third pump—a “contralateral limb exercise pump”—although the mechanism remains unclear. We suggest that it might be an effect of the pressure distribution of the superior vena cava during the exercise cycle.