The recommended treatment of clonorchiasis is the chemotherapeutic application of praziquantel, utilized for both the treatment and control of clonorchiasis . Praziquantel is also required for the treatment of other intestinal trematode infections. However, it has been reported that praziquantel exhibits low efficacy for the treatment of clonorchiasis in northern Vietnam . As dependency on a specific drug would be ineffective for any human trematode infections, novel anti-clonorchiasis compounds should therefore be developed to ensure continued or enhanced management of trematode-associated diseases.