For completeness of information longitudinal analysis without multiple comparison correction are also reported. The results demonstrated worsening of SARA scores: Total score (from 12.6 to 15.9; t(9) = -4.2, p <.01); Gait (from 3 to 3.7; t(9) = -2.7, p <.05); Stance (from 2.7 to 3.1; t(9) = -2.4, p <.05); and Sitting (from 0.7 to 1.3; t(9) = -3.7, p <.01). Analysis of kinematic data showed an increase of the knee shift towards extension during stance, as evidenced by the variation of Kc (from 14.4 to 8.2; t(7) = 4.2, p <.01), K1 (from 21.2 to 11.4; t(7) = 6.5, p <.001) and K2 (from 6.8 to -0.5; t(7) = 8.4, p <.001). Moreover, the ankle showed similar behavior with a shift towards the plantar flexion evidenced by the variation of Ac (from -3.9 to -8.6; t(7) = 2.4, p <.05), A1 (from -4.9 to -8.7; t(7) = 3.4, p <.05) and A2 (from 12.7 to 10.1; t(7) = 3.4, p <.05). In Fig 2 we illustrate this above mentioned statistical difference of gait pattern with a graphical representation of the co-variation plots of hip, knee and ankle angles. This graph shows clearly this difference of intra-limb coordination in comparison with controls, which became even more evident after one year follow-up (see S1 Fig for a 3D rotation of the hip-knee-ankle plot).