The above research about the formation mechanism of VBNC mainly focused on hypotheses and reasoning. At the molecular level, the research was mainly focused on the gene or protein level with some functions, which only partly reflected the formation mechanism of VBNC state. However, the study focused on the single and individual mechanisms, the lack of a comprehensive and systematic analysis. Most of the literatures to a single transcriptomics or proteomics approaches, the lack of integration analysis of the both, it is difficult to achieve information complement and functional verification (Capozzi et al., 2016; Feng et al., 2016). With the development and application of high-throughput sequencing technology and bioinformatics, in order to comprehensively and thoroughly understand the formation mechanism of VBNC state, researchers will use omics technology to study the formation of VBNC state mechanism.