Brain ageing research using d-galactose model in rodent, which mimics age-related cognitive impairment and oxidative stress, has recently gained a remarkable attention. Our results represented an overview of different aspects of the rodent d-galactose model and the neurobehavioral and neurochemical outcomes reported to better understand the characteristics of the model. This meta-analysis indicates the inconsistency and heterogeneity of the included publications, perhaps due to modest reported study quality or to other factors which influence the performance of the model which have not been identified here. These shortcomings should be addresses before efficacy in d-galactose models can be used as a signal to proceed with human clinical trials.