Helminth tegumental proteins have raised interest as both a diagnostic and potentially druggable therapeutic target , as they are essential for establishing the host and parasite relationship. The tegument, which covers the entire surface of the worm, comprises a unique outer surface syncytium structure that is of crucial importance for nutrient uptake, excretion, osmoregulation, sensory and signal transduction, host response modulation and parasite survival . To date, five genes encoding C. sinensis tegumental proteins have been identified and characterized; additionally, their potential as diagnostic antigens for clonorchiasis has been evaluated . However, their druggability has yet to be assessed.