In vivo MRI studies have reported an increase in overall iron accumulation without specifying the form of stored iron in the SN11. Ferric iron, whose strong paramagnetic properties alter MR signal contrast, is also known to bound to NM and ferritin411. The resulting NM-iron complex is one of the main iron compounds in SN dopaminergic neurons15. From the MR perspective, the paramagnetic NM-iron complexes may be detected by T2*-weighted iron-sensitive MR sequences as well as NM-sensitive T1-weighted imaging (T1WI), but their efficacy can change with an increasingly magnetic field and requires thorough validation. We hypothesize that NM would significantly contribute to the T2*-weighted hypointensity observed in the SN with increasing magnetic field strength. Similarly, the SN regions with a high NM content, such as nigrosome 1, may not appear fully hyperintense in T2*WI from the high magnetic field of 7T.