We performed whole exome sequencing on two families, in which diagnostic tests have identified a PKP2 mutation in affected and healthy individuals. Assuming a digenic mode of inheritance, we determined all genes, where in addition to the observed PKP2 variant a second causal variant was expected to be present in either the affected individuals or the PKP2 carriers. Filtering and prioritizing these genes, we determined four candidate genes in the first, and eleven candidate genes for digenic inheritance in the second family.