The overexpression of STHMN1 and OPN are very important in cancer metastasis. There is no relationship between resistance to TBR and the expression level of OPN or STHMN1 according to our study. OPN and STHMN1 are not suitable markers to predict response to TBR. Furthermore, our findings suggest that the evaluation of these two proteins may be a useful predictor of poor prognosis in patients with mCRPC.