The advent of proteomics and other high throughput omics-based technologies has highlighted the need for computational biology, as well as for state-of-the-art banking of experimental biospecimens. Improper documentation and storage of biologic specimen may result in skewed biochemical inferences, histopathologic analysis and predicted therapy. Hence, a good specimen biorepository is an essential infrastructure for development of high throughput omics based personalized medicine in Africa. Most ground breaking projects in the field of molecular biology such as the Human Genome Project (HGP) , The Cancer Genome Atlas (TCGA) , Human Proteome Project (HPP)  and Chromosome Centric Human Proteome Project (CHPP)  have benefitted immensely from specimen biorepositories. However, in Africa, it is apparent that there is a limited biobanking capacity and that procedures such as fresh snap frozen tissue sampling cannot be performed in most places because liquid nitrogen is largely unavailable. Furthermore, there has traditionally been a paucity of bioinformatics infrastructure and bioinformaticians in Africa, although this is now being addressed through National Institutes of Health (NIH)-funded training and capacity development initiatives, such as the H3ABionet consortium. The National Cancer Institute has described a biorepository as human specimen collection including relevant data for the purpose of research, and subject to relevant processes, ethics and policies [116, 117]. Despite the gamut of biorepositories established in the Americas, Europe, Asia and Australia [118–120], very few such biobanks have been established in sub-Saharan Africa . Most biorepositories in Africa are established within investigator's research group and most are yet to be standardized and centralized. Several challenges have plagued biorepository development and regulation in sub-Saharan Africa [121–124], albeit modest progress has been made in a few sub-Saharan African countries. Notably, the emergence of the NIH and Wellcome Trust-funded H3Africa consortium, has improved the centralization and standardization of biospecimen collection in Africa . Further collaborative effort is required by clinicians and scientists to standardize and improve the development of a centralized biorepository in Africa, such that high throughput ‘omics technologies can be backed by adequate research materials/resources, enabling them to play a central role in improving our current understanding of PCa in Africa.