The present empirical paper does not provide the space to review all evidence behind PARCS theory (for this we refer to review papers, e.g., Tops et al., 2010, 2014, 2016), however, we provide some examples from neuroimaging research that show integrated responding to both aversive and appetitive stimuli in areas that also facilitate processing of weak or ambiguous stimuli. Cortical components of the reactive system in PARCS (e.g., the AI and dACC) match what has been named the “salience network” in human neuroimaging studies: a key network in sensory perception and attention allocation (Seeley et al., 2007). Besides receiving projections from networks that seem more strongly involved in either reward or punishment processing, the salience network responds to salient stimuli in general, both appetitive and aversive (Hayes and Northoff, 2012; Hayes et al., 2014). Moreover, higher connectivity within the salience network was found to be associated with higher individual differences scores of harm avoidance and anxiety (Markett et al., 2013) and decreased connectivity of this network with areas of the reward system was related to decreased extraversion in depressed patients (van Tol et al., 2013). At the same time, the salience network seems involved in processing stimulus salience or relevance to a current task (e.g., detecting a sound) and to be activated whenever sensory input poses a challenge by sensory uncertainty or ambiguity, the disambiguation of which requires enhanced effort and alertness (Sterzer and Kleinschmidt, 2010; Lamichhane and Dhamala, 2015).