Topical preparations containing corticosteroids are widely used for the treatment of inflammatory skin diseases due to their anti-inflammatory effects. However, repeated or long-term application of topical corticosteroids may lead to numerous adverse events, including atrophy, striae, telangiectasia, purpura, acneiform eruption and perioral rosacea-like dermatitis . One of the options to reduce the adverse effects of topical steroids is to enhance their retention in the skin without augmenting the amount permeated, to reduce the applied dose. Clobetasol-17-propionate (CP) is considered the most potent of the currently available topical corticosteroids, as its vasoconstriction activity is 1800 times higher than hydrocortisone , but the incidence of unfavorable side effects is greater than other related compounds , limiting its clinical applicability . Some approaches to improve clobetasol administration have been recently described; they include the use of foam  or spray formulations , the application of ultrasounds  and of different kinds of nanocarriers such as microemulsions , nanogels , nanoparticles, nanocapsules, nanoemulsions  and nanostructured lipid carriers .