MiR-20 , miR-29b , miR-93 [23–25], miR-126 [26–30], miR-190 , miR-195 , miR-200 [33, 34], miR-203 , miR-497 [36, 37], miR-503  and miR-638  have been experimentally shown to directly target the 3’UTR region of VEGF-A mRNA in different types of cancer and subsequently impairing the pro-angiogenesis signaling of VEGF/VEGFR-2 in endothelial cells. These miRNAs are generally downregulated in cancer. Recently, the role of VEGF-C in initiating and potentiating neo-angiogenesis has been uncovered . MiR-27b and miR-128 functioned as inhibitor of tumor progression and angiogenesis through targeting VEGF-C [41, 42].