Model simulations also helped hypothesizing how PC dendrites process incoming synaptic inputs through BPRs. Dendritic Ca channels, primed by pf or aa EPSPs, would generate a depolarizing current flowing through the dendrites and activate a spike burst in the AIS. The corresponding raise in [Ca]i would activate KCa channels causing a protracted hyperpolarization, interrupting pacemaking and generating the pause. The whole process turned out to be very sensitive to the location of synaptic inputs on the dendrites. Actually, EPSPs amplitude was larger at longer electrotonic distances and this enhanced the threshold crossing for generating local Ca spikes, that could then spread around invading neighboring dendritic regions. Thus, the combined effect of dendritic structure and voltage-dependent ionic channels generated non-linear interactions sculpting the spatio-temporal profile of local [Ca]i and BPRs. It is tempting to speculate that this would eventually extend the plastic and computational properties of PCs beyond the linear perceptron hypothesized previously (Brunel et al., 2004).