(A) DINO is increased upon DNA damage in a p53-dependent manner and physically interacts with p53, resulting in p53 stabilization and activation of p53 target genes cell cycle arrest. (B) TP53TG1 is stimulated by p53 upon DNA damage and binds to the DNA/RNA binding protein YBX1 to prevent its activation of oncogenes. TP53TG1 inactivation by methylation in cancer cells releases the transcriptional repression of YBX1-targeted growth-promoting genes.