Inter-vial homogeneity of the three lots of RM 8671 was also evaluated for each lot using CE-SDS. The CV for monomeric purity ranges from 0.3% to 0.8% calculated from the results listed in ESM Table S8. Standard deviation calculated for intra-vial variation compared to inter-vial variation on the raw data for main peak purity was also similar (e.g. intra-vial SD = 0.053 vs. inter-vial SD = 0.137 for lot 14HB-D-001 monomeric purity). An F-test for equivalence of variance confirmed the standard uncertainties were statistically similar. Collectively these indicate inter-vial homogeneity with respect to monomeric purity was achieved.