The average litter size in wild type mice was reduced in the diabetic group relative to the non-diabetic control (Fig. 1D). In the case of Alx3-null animals, the number of embryos in non-diabetic pregnancies was lower than in non-diabetic wild type pregnancies, but litter size was not reduced further as a consequence of diabetes (Fig. 1D). In the diabetic mice, the differences in genotype did not affect the rate of empty decidua or the percentage of embryonic resorptions (Table 1).Table 1Pregnancy outcome in diabetic mice.GenotypeNumber of damsPercentage of females with empty deciduaNumber of implantationsPercentage of resorptions Alx3 +/+ 2231.8 (n = 7)8710.34 (n = 9) Alx3 −/− 4327.9 (n = 12)17211.62 (n = 20) Alx3 +/− 4425 (n = 11)19110.47 (n = 20)