At least one member of the K2P channel family has been identified in all mammalian cells investigated (neuronal and non-neuronal), with numerous cell types shown to express multiple K2P channels simultaneously (for example see ref. 36). K2P channels have been assigned prominent roles in many physiological systems, including cardiovascular3738, pain3940, respiration41, hearing4243, taste44, anaesthesia224546 and sleep474849. K2P channels have also been implicated in a number of pathological conditions, including autoimmune and degenerative diseases50, tumourgenesis5152, mental retardation (Barel-Birk-syndrome)53, migraine54, ischemia465556, epilepsy46 and depression465758. However, despite the accepted importance of K2P channels to neuronal function12161759, the expression and role of these channels in the retina remains largely unexplored. To date only one study has confirmed a role for K2P channels in the retina. Ford et al.60, have shown that TREK-1 contributes to slow after-hyperpolarisation events and regulates the frequency of retinal waves within starburst amacrine cells during early postnatal development. However, this study did not investigate the role of TREK-1 (or other K2P channels) in the adult retina.