N.V. and R.Pa. designed the research study; N.V., G.C. and R.Pe. performed experiments; N.V. and S.F. collected and analysed data; C.P. and L.V. provided some reagents and instruments; A.G., A.Z., C.P. and V.C. gave technical support and conceptual advice; N.V., G.C. and R.Pa. wrote the manuscript.