Previous studies reported the serum albumin level, serum alpha fetoprotein level, recurrent tumor size, time interval from primary hepatectomy to first recurrence, and time interval from treatment of recurrent HCC to second recurrence were significant prognostic factors to overall survival [23, 25, 28]. A shorter time interval from treatment to recurrence, is associated with poor prognosis. The finding of our study is consistent with the result of previous report by Albert C.Y. Chan, et al in 2012 . The univariate and multivariate analyses in our study also showed similar findings, except recurrent tumor size was not related to overall survival. Our finding can be explained by the relatively small recurrent tumor size in our study and complete elimination rate of recurrent tumor increase with a decreased possibility of the presence of satellite nodules which decrease early recurrence and improve overall survival. Moreover, the presence of HBV infection and younger age at the time of tumor recurrence were significant factors of better overall survival at univariate analysis. Although an acceptable long term survival is reachable in carefully selected elderly patients [40, 41], patient age is theoretically related to the post-treatment complication and disease morbidity and is always more relevant for the prognosis than many tumor and treatment factors. However, the reason why the presence of HBV infection was also a favorable factor was unknown. It was probably because all HBV patients with indication (45.3%) in our study had anti-viral agent treatment, which had been proved to reduce HBV related long-term complications and lead to better prognosis .