Development of hypertension was also accompanied with an increasing circadian BP dipping response: the difference between day/night MAP on a low-salt diet was 17.4 ± 2.1 mmHg whereas on a high-salt diet this value rose to 27.2 ± 0.8 mmHg on day 8 and 43.6 ± 5.9 mmHg by the end of experiment (Figure 2D). We also observed a temporary significant drop in heart rate after switching the diet, which recovered by day 21 (Figures 2E,F).