Currently, several studies are ongoing assessing various aspects of the use of licensed vaccines such as influenza and pertussis in pregnant women, as well focusing on the development of new vaccines specifically designed for administration during pregnancy, for the protection of infants against RSV and GBS in early life. Numerous RSV and GBS vaccines are in various phases of development, from preclinical to clinical trials, supported by multiple stakeholders from industry to private and public organizations (34–36). One RSV vaccine is currently in phase III of clinical development, promising, if successful, to be the first vaccine developed and licensed for specific use in pregnancy. Achieving this milestone has the potential to positively impact and change the landscape and practical applicability of infant disease prevention through maternal immunization. In addition to research focused on basic placental biology and immunology, understanding the role of passive and breast milk antibodies in infant protection and responses to natural infection and active immunization, and determining how to optimize maternal intervention to improve its safety and efficacy, other aspects that require further study include those related to acceptance, feasibility, and logistics of implementation of maternal immunization in different settings and populations. Furthermore, aspects related to education of mothers and providers, utilization, communications, and long-term surveillance and assessment of vaccine safety are paramount for the success of maternal immunization as a public health strategy to improve maternal and child globally. The field of maternal immunization research is therefore open, active, and rich.