A recent Cochrane review showed montelukast to be ineffective at reducing courses of oral corticosteroid (OCS) in viral-induced wheeze . The European Respiratory Society (ERS) has recently highlighted the overlap of viral-induced and multiple-trigger wheeze . This meta-analysis aims to investigate the effectiveness of montelukast in all wheezing preschool patients, which is a more clinically relevant and ‘real-life’ group.