Supaglutide improves lipid profile in the DIO mice. (A) Total cholesterol (TC), high density lipoprotein (HDL), and low-density lipoprotein (LDL). (B) Triglyceride (TG). (C) Nonesterified fatty acids (NEFA). Significant difference between control and SPG is determined using unpaired Student's t-test. All values are means ± SE (n = 5 for each group). **p < 0.01; ***p < 0.001.