Copaiba oleoresins have exhibited both in vitro and in vivo antiproliferative activities (Table 3). Copaifera reticulata oleoresin, for example, has shown in vitro cytotoxic activity against GM07492-A human lung fibroblast cells with an IC50 of 51.85 μg/mL . The oleoresin of C. multijuga has shown in vitro cytotoxic activity against B16F10 murine melanoma cells with an IC50 of 457 μg/mL . Furthermore, in a mouse model of lung metastasis and tumor growth, oral administration of C. multijuga oleoresin reduced tumor growth, tumor mass, and number of lung nodules after inoculation of B16F10 tumor cells . Likewise, C. multijuga oleoresin, in doses varying between 100 and 200 mg/kg, showed antineoplastic properties against Ehrlich ascetic tumors and solid tumors in an in vivo mouse model . On the other hand, C. officinalis oleoresin actually stimulated growth of Walker 256 carcinoma by 70% in an in vivo rat model .