Dengue virus (DENV) and Zika virus (ZIKV) belong to Flaviviridae family and both diseases affect significantly human health. These viruses are mainly transmitted by Aedes aegypti or albopictus infected mosquitoes. Other routes of infection, including sexual, maternal, and blood transfusions, have been recently reported for ZIKV 1. DENV and ZIKV, like other flaviviruses, are single‐stranded, positive‐sense RNA viruses with a genome of 10.7 kb and two flanking non‐coding regions (5′ NCR and 3′ NCR). The open reading frame encodes one polyprotein with three structural proteins: capsid, pre‐membrane/membrane, and envelope and seven nonstructural proteins: NS1, NS2A, NS2B, NS3, NS4A, NS4B, and NS5 2. Four serotypes of DENV (DENV‐1 to −4), antigenically distinct have been described 3. In ZIKV, two major lineages, African (Nigeria, Senegal, and Uganda strains) and Asian (Malaysia 1966, Yap State 2007, and Cambodia 2010) have been described based on full genome sequences of the ORFs 4. The four DENV serotypes share approximately 70% amino acid identity with each other, while ZIKV displays an overall 43% homology with DENV (with up to 68% identity for more conserved non‐structural proteins) 1.