A case of non-CNS THRLBCL mimicking LYG was reported by Olivieri, et al. . The previously healthy patient presented with a large abdominal mass, left-sided inguinal adenopathy, and pulmonary nodular lesions. Pathological findings were remarkable due to the proliferation of EBV-negative large B-cells intermingled with non-neoplastic T-cells and perivascular hypercellularity. The lesion had a stronger malignant profile compared to our case, probably reflecting a different background in immunocompetency. The difficulty of managing these cases points to the need to understand better which signals provoke the infiltration of T-cells.