Further, a needle biopsy of the cervical lymph node again revealed T-cell-dominant lymphatic pleocytosis. Flow cytometry demonstrated cellular components similar to those found in the other sites (Figure 3A). However, atypical large cells, which were positive for CD20, weakly positive for paired box 5 (PAX5), CD5, CD30, CD3, CD4, CD8, and TIA-1 and negative for granzyme B, were remarkably commingled with morphologically normal immune cells (Figure 3B). LMP and EBNA2 were negative, but some of the large cells were positive for EBER. The diagnosis of T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) was made based on the cellular composition and the molecular profile.