Borch-Johnsen et al. showed the direct relationship between proteinuria and cardiovascular mortality rate in insulindependent diabetic patients after open-heart surgery in patients undergoing CABG.24 Telmisartan was also shown to reduce or normalise microalbuminuria in 34% of patients with diabetes, and in a second, smaller study including 64 hypertensive and 60 normotensive patients, to reduce the incidence of renal dysfunction. This confirmed that telmisartan reduced microalbuminuria independently of its blood pressure-lowering effects. Restoration of normal urine albumin levels has also been demonstrated by telmisartan.25