Mindfulness, a new therapeutic model proposed for the management of chronic stress, consists of an individual’s awareness of and attention to his or her symptoms of emotional distress experienced under chronic stress. This strategy facilitates therapies and enables the modifications necessary to improve lifestyle. This intervention is practiced by Manolete S. Moscoso at the University of South Florida. The purpose of this therapeutic intervention program is to instruct the individual in the relaxation response, reduce the level of chronic stress and change patterns of self-destructive behavior, obtaining an immune and neuroendocrine benefit that promotes the restoration of health and helps control the symptoms caused by medical treatments, which allows patients experiencing severe depression to counter the recurrence of this disease. Mindfulness allows focus and consciousness in the body through breathing, in the mind through thought, and the environment through the senses. The belief of “living on the run” from stress and emotional pain through daily life experiences contributes to fear, tension, anxiety, worry, anger and hostility. When behavior is modified in response to the difficulties of life and when it is understood that pain and pleasure are genuinely human experiences, an individual can achieve an adequate level of acceptance and peace [18, 62].