The median PFS was 4.13 (95% CI 3.44–4.83) m. The median TTF was 3.70 (95% CI 2.60–4.80) m. The median OS was 11.40 (95% CI 7.76–15.05) m (Fig. 1).Fig. 1Kaplan–Meier curves for the entire population. a Progression-free survival, b time to failure, and c overall survival