The science of metabolomics looks at the differential signature of metabolites in biological pathways in a high throughput manner. Tiziani et al.  identified metabolomics signatures for early diagnosis or oral cancers using 1H-nuclear magnetic resonance (NMR) spectroscopy methods. This method could potentially be used for routine early clinical diagnosis of various oral cancers. Recently, the push for reliable non-invasive timely diagnosis of cancer has directed research interest in the area of exhaled breath analysis for early detection. Breathomics is a branch of metabolomics that measures the total amount of volatile organic compounds (VOCs) in exhaled air . Volatile and nonvolatile organic components of the exhaled air are relevant indicator of metabolic status for clinical diagnosis and monitoring purposes . Various metabolic processes in the body produce VOCs that are released into the blood and transported to the lung where they are passed to the airway and exhaled. Acquisition and measurement of unique VOCs that may indicate occurrence of chronic inflammation and/or oxidative stress are potential biomarkers for early cancer detection . This may be a plausible non-invasive early-stage cancer screening tool and may be potentially applied to the detection of head and neck cancers.