8) Figure 5—figure supplement 1 lanes 11-13. CMG-Mcm10 can clearly bypass a leading strand roadblock, however the authors do not comment on this remarkable observation. Is SA kicked off of the DNA or is there a more complicated leading strand roadblock bypass mechanism to be uncovered? Using DNA-Protein crosslink (methyltransferase?) as a roadblock would address this issue. If SA is kicked off of the leading strand template, this might simply mean that the bypass effect observed here is due to a stimulation of the ATPase activity (CMG-Mcm10 powers through the roadblock). Could the authors address this point? Does Mcm10 stimulate ATP hydrolysis by MCM to a different extent compared to e.g. MTC, which the authors already use as an informative control in this study?