Nicotine is the addictive component of tobacco. It induces adverse effects during pregnancy and contributes to the progress of cardiovascular disease. Although nicotine itself is not a carcinogen, it functions as a “tumor promoter”. Nicotine is involved in neurodegeneration and other malignant diseases. Therefore, the use of nicotine in children, adolescents, pregnant women and women of reproductive age should be treated with great caution, due to the effects of nicotine on the brain . The effects of nicotine on the cardiovascular system will be elaborated in the following chapters.