Crosstalk between integrins and growth factor receptors has been extensively studied and can be bidirectional (Giancotti and Tarone, 2003). Cabodi et al. showed that integrin-EGFR complex formation is necessary for EGR1 expression that is induced by integrin-mediated adhesion (Cabodi et al., 2009). Inhibition of β1-integrin caused significant (p < 0.05) reduction in the induction of EGR1 by N. meningitidis, N. gonorrhoeae, S. pyogenes, H. pylori, and S. Enteritidis. In addition, the inhibition of EGFR completely abrogated the induction of EGR1 by N. meningitidis, N. gonorrhoeae, S. pyogenes, H. pylori, and S. Enteritidis.