Glycosylation is an enzymatic process through which a glycan is covalently attached to a second biomolecule. Glycosylation is a very common form of PTM of ECM proteins. Attached glycans affect ECM protein structure and function by influencing its folding, solubility, aggregation, and/or degradation behaviour.83 Indeed, aberrant glycoforms are already approved as biomarkers for cancer.84 In cardiac tissue, Montpetit et al.85 showed that aberrant glycosylation of extracellular domains alters ion channel activity.