Briefly, mono‐ and coinfections similarly induced expression of CCR5, CX3CR1, and CXCR3 on CD4+ and CD8+ T cells. This could promote functional and migratory similarities of these cells, regardless of the infecting virus. However, DENV/ZIKV coinfection decreased the ability of CD4+ T cells to produce IFNγ+, TNF+, TNF+IFNγ+, and TNF+IL2+, compared to monoinfections. We suppose two antagonistic scenarios: coinfected people are more immunocompromised than those monoinfected, so coinfection would be the worst scenario for those individuals. Another example of potential adverse effects of this immunosuppression is, that a reduced capacity to activate CD4+IFNγ+TNF+ and CD4+TNF+IL2+ T cell populations might interfere with future development of specific or cross‐reactive memory lymphocytes, leading to a weak response in a subsequent encounter to other potential arbovirus. In the other scenario, coinfected people have a less inflammatory milieu than monoinfected people. This could mean that a reduced inflammatory condition could avoid harmful effects like cytokine storm. Nevertheless, once the clinical outcome of the patients was similar, it was not possible to associate the symptoms and clinical signs with the immune profile of each group.