P2Y12R-Gi signaling leads positive regulation of other intracellular pathways including extracellular-signal-regulated kinase (ERK), myosin light chain kinase and Src family kinases as well as to membrane lipid shifts toward a pro-coagulant state such as phosphatidylserine and P-selectin exposure (Leon et al., 2003; Gachet, 2012). By acting on P2Y12R, ADP also contributes to the release of several agonists such as TXA2 (Cattaneo, 2015).