To examine the anti-tumor effects of PA-MSHA in vivo, we subcutaneously injected nude mice with PANC-1 cells into the right hind limb. The mice were then injected intraperitoneally with NPT for 7 weeks. The mice were euthanized 42 days after transplantation and the tumor tissue collected. We found that the average tumor volume was larger in the control group than in the PA-MSHA group (714.51 ± 101.73 mm3 vs. 187.64 ± 28.58 mm3, p < 0.01). Overall, the tumors in the PA-MSHA treatment group were significantly smaller than those in the control group (Figure 7B). Finally, an additive effect was observed when the two agents were combined (Supplementary Figure 1A). Thus, PA-MSHA and NPT could reduce tumor growth in a xenograft model of pancreatic cancer.