Prostate cancer (PCa) is one of the leading causes of cancer death in men globally . Factors responsible for aggressive or indolent phenotypes of PCa are poorly understood. The chances of developing PCa significantly increases after the age of 40 years . However, even without any form of therapy, PCa often runs a protracted natural history and many men die with it rather than from the disease . Over a million new cases are reported annually according to the GLOBOCAN/ IARC 2012 databases; PCa is the fifth leading cause of cancer death in men globally, accounting for up to 307,000 deaths annually . Among cancers in Africa, PCa was reported to have the highest incidence (59,493), mortality (42,802) and 5 year prevalence rate (155,028).