Neurofibrosarcoma (MPNST3) tumor tissue was transplanted subcutaneously into the right flank of ICR-SCID mice and chondrosarcoma (JJ012) cells were implanted subcutaneously into the right flank of athymic mice (15 million cells/mouse). Once tumors reached a size of 100–150 mm3, mice were either treated with SDRT and/or Pazopanib (100 mg/kg, orally). Radiation was delivered using a Philips MG-324 X-ray at 117 cGy/min (50 cm source to skin distance). Mice were lightly sedated with ketamine (0.1 mg/g) and xylazine (0.02 mg/g) and only tumor, surrounding skin and subcutaneous tissues were exposed using a specialized lead jig. Tumor volumes, based on caliper measurements, were calculated daily using the formula of V = (W2 × L)/2 .