Examined in male mice, intraperitoneal glucose tolerance (IPGTT) was not different between control and βVps13cKO animals up to the age of 16 wk, whereas βVps13cKO mice became glucose intolerant at 20 wk of age (Fig. 4, A, C, E, G). Although glucose tolerance was lower at all ages examined compared with animals maintained on RC, no differences were observed between control and βVps13cKO males maintained for up to 16 wk (i.e., 20 wk old) on a HFD (Fig. 4, B, D, F, H).