The dataset used in this challenge is specific to one subject who underwent a long‐duration acquisition, which adds to the question of generalizability. The subsequent preprocessing of the data is also a factor to bear in mind: the registration of two 4h datasets, across such a broad range of echo times, poses its own challenges for certain non‐homogenous regions in the brain, such as the fornix (compared with, for example, the relatively large genu). Thus the results may be somewhat subject‐specific and may be affected by residual alignment errors.