MicroRNAs (miRNAs) are short non-coding RNA molecules that usually repress gene expression by binding to the 3'-untranslated region (3'-UTR) of their target mRNAs. Increasing evidence indicates that miRNAs have important roles in tumor formation and immunogenicity.12, 13, 14 A group of miRNAs was predicted to target the mRNA of the NKG2DLs by the TargetScan database.15 Previous study found that miR-20a, miR-93, miR-106b, miR-373 and miR-520d could repress MICA and MICB expression by binding to the mRNA 3'-UTRs in human cancer cells (mainly HeLa, 293T, DU145 cells) and normal cells (human foreskin fibroblasts and human umbilical vein endothelial cells).16 Paula Codo et al.17 found that miR-20a, miR-93 and miR-106b contributed to the immune evasion of glioma cells by inhibiting MICA/B. These data led us to question whether miRNAs contribute to the post-transcriptional regulation of NKG2DL expression and how they influence the immunogenicity in the context of BC.