GBM almost always leads to the loss of independence by increasingly developing disabilities throughout the course of disease; the loss of independence is mostly due to progression of the disease . RT, chemotherapy as well as combined modality treatments have shown to prolong the progression free survival and to increase the OS, too [2, 15, 16]. Based on reports about increased toxicities of either of these treatments in elderly patients, mono-therapeutic regimens have emerged [2, 10, 11]. All of these aim on minimizing the burden by the treatment, and, all of them have demonstrated mOS between 6.4 and 9.6 months in elderly people [2, 10]. Inclusion criteria of these trials were mostly based on age (65 years or older) and a modest to good performance status (Karnofsky Performance Score (KPS) of at least 60% or ECOG of 2 or less).