Finally, we analyzed the influence of different SOD2, CAT, and GPx1 genotypes on the variability of muscle damage markers (Table 4). In resting conditions significant differences were found only for water polo players having either the SOD AV16 genotype or the VV16 genotype that exhibited greater myoglobin or greater troponin, myoglobin, and CK-MB values, respectively, in comparison with wild-type athletes. Instead, the CAT −844 G>A and the GPx1 rs1800668 C>T did not affect plasma concentrations of muscle damage markers. After exercise we found that athletes with SOD2 AV16 genotype had higher LDH concentrations than those with AA or VV genotype, while athletes having the SOD VV16 genotype had significantly higher concentrations of CK and myoglobin in comparison with wild-type AA or heterozygous AV ones (Table 4).