The number of cancer cases, which are diagnosed each year continues to rise, primarily due to an aging population. According to a recent report by Weir et al. (2015), this increase, in the United States, in all races and all sites, will be of 24,1% among men and of 20.6% among women within 2020. Cancer, along with cardiovascular disease (CVD), remains the most common cause of death. Most of the cancer-related deaths are due to the metastatic process, which is regulated by different mechanisms including the interaction of cancer cells with other cellular components present either in the tumor microenvironment or in the bloodstream (De Palma et al., 2017). Emerging evidence has recognized a central role for platelets in both tumor progression and metastasis (Contursi et al., 2017) and paraneoplastic thrombocytosis is observed in more than 30% of subjects diagnosed with different types of solid tumors, where it is associated to poor prognosis (Haemmerle et al., 2017).