The increase in cytokine production caused by Helicobacter pylori has been studied before, including the anti-inflammatory cytokine. This cytokine is responsible for the decrease in immune response. IL-10 is an anti-inflammatory cytokine that is capable of decreasing the inflammatory responses caused by H. pylori, which will cause the rise in bacterial num-bers and the effects mediated by the epithelial cells of the gaster . Patients with chronic gastritis caused by H. pylori infection often develops peptic ulcers, as well as gastric carcinoma and lymphoma .