MH is a genetic disorder of skeletal muscle calcium regulation in humans, linked to the ryanodine receptor type 1 (RYR1) gene. Many studies from the past report an incidence of MH ranging from 1:10,000 to 1:220,000. This suggests that the precise incidence of MH is difficult to estimate due to its rarity and limited data. In addition, the incidence of MH seems to vary, depending on the geographic region, age, gender, and race.[1,3–6] Systematic reviews and meta-analysis have been increasingly used to formulate public health policies and to guide resource allocation to improve population health outcomes.