The study firstly surveyed PARP1's effect on NSCLC cells and discussed its functionary mechanism, which found that PARP1 was expressed strongly in metastatic NSCLC; and high PARP1 expression was relevant to prognosis and facilitated NSCLC cells migration and invasion, which provided not only corresponding foundation of experiment medicine for later targeted treatment studies but theory support of PARP1 expression within NSCLC and possible mechanism research.