aReactions carried out in 3.0 mL of Milli-Q water with 5.0 equiv of styrene and 1.0 equiv of ethyl diazoacetate. bCatalyst loading in mol %. cConversion of ethyl diazoacetate into cyclopropane product. dDetermined by 1H NMR using triethylene glycol dimethyl ether as an internal standard. eDetermined by chiral GC. fPolymersomes started to precipitate after 15 min. gConfiguration of the product was (1S,2S). hIsolated yields. iDetermined by chiral HPLC. Adapted from reference .