Various proteomics approaches have improved the individualization of prostate cancer therapy. An integrative approach using these proteomics methodologies would improve the identification of proteomics biomarkers of prostate cancer. As shown here, proteomics approaches such as MS-based proteomics, protein microarrays-based proteomics, interaction network proteomics, proteogenomics and well as posttranslational modification proteomics have all been of great benefit in biomarkers development for personalized/individualized therapy of Prostate cancer.