Taken together, VOSL contained multiple anti-cancer ingredients, at least Cos and Dehy, which targeted multiple signaling pathways, at least c-Myc/p53, AKT/14-3-3 and PKA signaling pathways to exhibit synergistic anti-breast cancer efficiency, and our previous study demonstrated that VOSL and CD shows better anti-breast cancer efficacy and lower side effects than Cos or Dehy alone in vivo3. Therefore, it is expected that VOSL and CD may serve as novel anti-tumor agents in prevention and treatment of breast cancer.