Spina bifida occulta (SBO) is the second major form of NTDs, where the site of the lesion is not left exposed [129, 130]. Spina bifida occulta encompasses lipomyelomeningocele (Figure 1(d)), lipomeningocele (Figure 1(e)), and spinal dorsal dermal sinus tract (Figure 1(f)) ranging phenotypically from (i) dysplastic skin, (ii) tuft of hair, and (iii) vestigial tail as well as other forms of spinal dysraphism, which lack a pathogenic representation when the vertebrae develop abnormally leading to absence of the neural arches [131, 132]. In symptomatic cases, tethering of the spinal cord within the vertebral canal can result in pain, weakness, and incontinence in otherwise normal, healthy children or adults .