Translation is responsible for the production of proteins that are essential for cellular functions (Gebauer and Hentze 2004; Sonenberg and Hinnebusch 2007; Spirin 2009). One key feature of translation is that cellular mRNAs are translated differently, as a result of the difference in interactions between mRNAs and the translational machinery (Vogel et al. 2010; Gingold and Pilpel 2011). In principle, for a multistep cellular process like translation, regulation can take place at each step and can target numerous proteins or RNAs involved (Merrick and Hershey 1996). Nevertheless, this process is predominantly regulated during initiation (Sonenberg and Hinnebusch 2009; Jackson et al. 2010; Hinnebusch and Lorsch 2012), the step when interactions between 5′ untranslated regions (5′UTRs) of mRNAs and cellular proteins determine how ribosomes will be recruited to the mRNAs to start translation.