We compared the serum markers levels at starting point between patients who had developed HCC and those who had not developed HCC; the results demonstrated that there were 4 markers, including AFP, AFP-L3, ALT, and AFP-L3/AFP ratio, that were statistically significant (p < 0.05); see Table 2 and Figure 1. It is evident that the increase of AFP, AFP-L3, and ALT levels in serum and AFP-L3/AFP ratio are potential precursors of HCC; thus regular monitoring of these markers seems necessary in hepatic cirrhosis patients.