Recurrence of families in Vitis vinifera L. varieties is not a new feature, indeed it is well known that at least 23 varieties of the northeast of France, some of them are spread internationally by now, are all progeny from repeated crosses starting from early middle age of Pinot noir and Gouais blanc (Bowers et al. 1999a; Lacombe et al. 2013). Whether the new South Italian family of varieties originated from spontaneous crossing or there were intentionality created, remain a matter of speculation. Althoug science was highly developed in antiquity, the first reported experiments addressing the sexual reproduction in higher plants and assigned the male role to pollen, dates back to the late seventeenth century carried out by the German botanist R.J. Camerarius and brought to an outbreak of experiments in the following centuries up to the celebrated crossings of the Father of Genetics, the Czech monk Gregor Mendel.