It is well documented that bleomycin, like most other chemotherapeutic drugs, can mediate DNA changes in both cancer cells and normal cells. As with ionizing radiation, Bleomycin mediates its genotoxic effects by inducing DNA double strand breaks (dsbs) which is one of the critical lesions for cellular death . This “radiomimetic” agent induces such double strand breaks by highly specific, concerted free radical attack on deoxyribose moieties in both DNA strands [33, 34]. Although the lesion induced by bleomycin is supposed to be only a small subset of the many lesions induced by ionizing radiation, effects of this radiomimetic agent in cells are remarkably similar to those of ionizing radiation .