T cells have an essential role in protection against a variety of infections. Indeed, the development of successful vaccine formulations will require the generation of potent and long‐lasting T‐cell responses. However, there are still no clearly defined immune correlates of protection for these infections 23. The role of T cells during dengue infection is still controversial, with studies supporting either an immunoprotective or immunopathological role (reviewed in 24). Pioneer studies proposed that T cells have a detrimental role during secondary dengue infections in a process termed “original antigenic sin.” Based on this theory, cross‐reactive T cells generated during primary infection, which recognize secondary‐infected DENV serotype with low affinity, are poorly functional but prone to inducing immunopathology 25. Thus, cross‐reactive memory T cells are present in increased numbers and have a low activation threshold. They may outcompete their naïve subsets that have high affinity for secondary‐infected serotype with an overall detrimental outcome for protective immunity 25. Collectively, studies showed that dengue infection elicits a broad specific T cell response that peaks around day 8–10 from fever onset 24, 26. Dengue‐specific CD8+ T cells are present at higher frequencies compared to their CD4+ counterparts and preferentially target non‐structural proteins NS3, NS4b, and NS5, while CD4+ T cells are mainly directed toward the capsid envelope and the secreted protein NS1 27. A comparison of amino acid sequences of DENV and ZIKV CD8+ T cell epitopes point out a high sequence homology between the two viruses and suggests that some of these CD8+ epitopes may also exist in ZIKV 24.