Thus, the characteristics of the 3-D scaffold such as mechanical properties, pore size, surface property, and degradability were very important as a culture media for the tissue engineering. The characteristics of the scaffold is also depends on the cell or tissue types. For example, the pore size was also employed differently such as 380~405 μm pore size for chondrocyte and osteoblast growth, and 186~200 μm pore size for fibroblast growth . Besides, there are also many researchers had studied mechanical properties and degradation behaviors for the various biodegradable polymer scaffolds [1, 4–6]. The mechanical properties and degradation behaviors are among the important factors because they are related to the structural and mechanical stability for the tissue regeneration [1, 5]. Thus, the physical properties of 3-D scaffolds must be taken into consideration by using innovative approaches. One of the most important factors for cell proliferation is mechanical stimuli to the cell. There are various methods for mechanical stimulation that will affect the cell behaviors such as compressive loading that is divided into hydrostatic pressure and platen displacement in a 3-D specimen, longitudinal stretch, substrate bending, plane substrate distention, and fluid shear system .