Three different sets of criteria are used to diagnose of DRESS syndrome: RegiSCAR criteria, Bocquet’s criteria and Japanese consensus group to diagnose DIHS . RegiSCAR criteria include at least 3 of the following 7 characteristics: 1) skin eruption; 2) fever > 38°C; 3) lymphadenopathy involving at least 2 sites; 4) involvement of at least 1 internal organ; 5) lymphocytosis (> 4000/mm3) or lymphocytopenia (< 1500/mm3); 6) blood eosinophilia (> %10 or 700/mm3) and 7) thrombocytopenia (< 120.000/mm3 ) . Three of the four main criteria (fever > 38°C, lymphadenopathy at least 2 sites, involvement of at least 1 internal organ and blood abnormalities) are required for the diagnosis of DRESS syndrome. Additional criteria are hospitalization and drug induced reaction [6, 8, 9]. Our patient met 6 of 7 RegiSCAR criteria and he also had two additional criterias ( hospitalization and drug induced reaction).