The mice were randomly divided into six groups with 8 animals for each. One group was selected as NC group, which was treated with physiological saline, while the other five groups of mice were subjected to immunosuppression by administration of CY (100 mg/kg) intraperitoneally for 3 days. Then mice in AHG groups were intraperitoneally injected AHG at the dose of 1, 5 or 10 mg/kg body weight, respectively, once a day for the next 7 consecutive days, while mice in positive control group were treated with 1 mg/kg body weight LNT. Other mice and model control (MC) group were only given physiological saline at the same intervals. The animals were sacrificed by decapitation at 24 h after the last administration and heart, liver, kidney and spleen tissues were excised rapidly for further analysis.