Several multi-target TKIs have potent anti-angiogenic effects due to the inhibition of VEGFR and PDGFR, and have been approved, including sorafenib for mRCC and unresectable hepatocellular carcinoma (HCC), and sunitinib for mRCC. High level of miR-425-3p was associated with longer PFS in HCC patients treated with sorafenib. Multivariate analysis confirmed the predictive significance of miR-425-3p, suggesting that assessment of miR-425-3p levels in liver biopsies could help in stratifying patients with advanced HCC for sorafenib treatment . Khella et al. compared miRNA profile between patients with a short (≤12 months) versus prolonged (> 12 months) PFS under sunitinib as first-line therapy for metastatic RCC. They developed miRNA statistical models that could accurately distinguish the two groups. MiR-221 overexpression was validated to be associated with a poor PFS, while its target VEGFR2 was associated with longer survival . In another study, miRNA profiling in tumor tissues of sunitinib-treated mRCC patients was performed by TaqMan Low Density Arrays. Decreased tissue levels of miR-155 and miR-484 were significantly associated with increased time to progression (TTP), suggesting miR-155 and miR-484 are potentially connected with sunitinib resistance and failure of the therapy .