AS carried out the immunoblotting, performed the statistical analysis and the transient transfection, drafted and prepared the manuscript for submission, worked with cell cultures; AVK synthesized steroidal compounds; ASK synthesized steroidal compounds, prepared the supporting information; MY worked with cell cultures; OA performed the reporter analysis, worked with plasmids; VS managed the project; IZ managed the project; AH managed the project; YV wrote the manuscript, conceived of the study, in silico analysis, and managed the project; All authors read and approved the final manuscript.