The use of human patient biological samples (FLS) in this study was approved by the Institutional Review Board of the Lyon University Hospital and the French Ministry of Education and Research (Authorization #AC-2010-1164). Informed consent was obtained from the patients. Animal experiments were performed in full compliance with the Ethical Committee Guidelines and Regulations for Animal Protection of the Loire in accordance with the legislation of the European Community, and received approval from the Ethical Committee for Animal Experiments of the University Jean Monnet in Saint-Etienne (Authorization #CU-14N1402).