The differentially expressed proteins at different treatment groups were imported into the IPA software for pathway analysis, the results demonstrated that the top pathway is c-Myc mediated apoptosis signaling and 14-3-3-mediated signaling for Dehy or Cos treatment, respectively (Fig. 3A and B), VOSL and CD shared the common top pathways, c-Myc mediated apoptosis signaling and protein kinase A (PKA) signaling (Fig. 3C).