In 1996 Bomgioanni  confirmed previous results  and showed a significantly decreased percentage of CD4 + CD45RA+ cells in peripheral blood during a relapse in RR-MS. Decrease in CD4+ CD45RA+ subset was also detectable one month before clinical relapse.  Up regulation of naive CD45RA+ T- lymphocytes and parallel down regulation of memory CD45RO+ cells seemed to be one of the main mechanisms by which Linomide inhibited the MS activity.  Also in this study, the higher levels of naive CD4+ cells seem to be a positive prognostic marker.