Glide focuses towards the orientation of the molecule, its position and the conformation, which screen large libraries. Glide docking applies three different scoring functions; they are Standard precision docking (SP), High throughput virtual screening (HTVS) and Extra precision docking (XP). Both HTVS and SP docking use the same scoring function. The HTVS minimize the immediate conformations throughout docking, and reduces the torsional refinement and more suitable for screening more ligands. XP docking is found to be superior to SP docking in terms of sampling. XP docking reduces the false positive and has more additional terms than SP. In the docking methodology, initially Glide uses hierarchical filters for finding the active site regions for ligand binding in the receptor molecules. Poses means the alignment, position and conformation with respect to the receptor. The next step is the ligand screening, which is an exhaustive search based on torsion angle space. After the ligand screening, it is minimized using molecular mechanics energy function, which is said to be a reasonable model in prediction of binding modes . The best poses are given by E-model score which deals with the van der Waals and electrostatic forces. Glide score represents the buried polar groups and steric clashes, which ranks different ligand poses, where the more negative value represents the tighter binding affinity .