TDG has been found in complex with AID and GADD45A in the context of active DNA demethylation and evidence exists that glycosylase activity is necessary for this process45. As shown in Fig. 6C, there was substantially lower nuclear TDG protein expression in Panc1-2G6 compared to Panc1-3D7. As seen in Fig. 6D, this stable knockdown of TDG resulted in marked downregulation of AREG and EREG in Panc1-3D7 cells, indicating that TDG is necessary to maintain expression of AREG and EREG downstream of integrin α6β4, potentially through preferential localization of TDG into the nucleus.