As the positive effect of RT in elderly patients is not a matter of debate anymore , several alternative dosing-regimens have been tested in prospective trials. Exemplary, Roa and colleagues demonstrated non-inferiority of a 3 week regimen compared to the 6 week standard regimen of radiotherapy . Recently, Roa and colleagues demonstrated, that also an even more hypofractionated one-week-regimen is equal-effective in elderly and frail patients compared to the formerly described mildly hypofractionated 3 week course . Of note, neither of these two regimens were tested together with concomitant chemotherapy.