Lamotrigine (LTG) is a phenyltriazine derivative which is used in the treatment of epilepsy and bipolar disorder. It is one of the aromatic antiepileptic drugs (AEDs) which together are the most common cause of cutaneous adverse reactions (CADR) (Arif et al., 2007). The current widely used AEDs include carbamazepine (CBZ), oxcarbazepine (OXC), phenytoin (PHT), and phenobarbital (PB) (Maggs et al., 2000; Arif et al., 2007; Chung et al., 2010). CADR manifestations range from mild maculopapular exanthema (MPE) to severe cutaneous adverse reactions (SCAR), including Stevens–Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reactions with eosinophilia and systemic symptoms (DRESS). The mortality rates are 1–5% of patients with AED-induced SJS and up to 30% in AED-induced TEN (Roujeau and Stern, 1994; Harr and French, 2010; Yang et al., 2011). The incidences of SJS and TEN range between 1 and 10 cases per 10,000 patients (Mockenhaupt et al., 2005).