A. Quantile-quantile plot of binomial test P-values for enrichment of variants with Pv<0.05 among variants with Pm<0.05. Quantile-quantile plot of binomial test P-values for enrichment of variants with Pv<0.05 among variants with Pm<0.05. The figure illustrates 2,500 binomial P values testing for enrichment of variants with Pv<0.05 among all variants with Pm<0.05. Pv and and Pm values drawn from a simulated dataset of 44,000 individuals and 50,335 SNPs. In the figure, distribution under the null hypothesis is represented as a black line while its 95% confidence interval is represented as dashed gray lines. B. Quantile-quantile plot of binomial test P-values for enrichment of variants with Pv<0.05 among variants with Pint<0.05. Quantile-quantile plot of binomial test P-values for enrichment of variants with Pv<0.05 among variants with Pint<0.05. The figure illustrates 2,500 binomial P values testing for enrichment of variants with Pv<0.05 among all variants with Pint<0.05. Pv and and Pint values drawn from a simulated dataset of 44,000 individuals and 50,335 SNPs. In the figure, the distribution under the null hypothesis is represented as a black line while its 95% confidence interval is represented as dashed gray lines. The dashed red line represents the correlation P value obtained from the “real data” analysis presented in the main text.