The intersection of Fam1 and Fam2 genes with the PKP2-related genes was prioritized using the Dintor MetaRanker tool , by equally weighting gene expression, number of variants, variant class (consequence class “high” was rated higher than class “moderate”), minimum ExAC allele frequency of the gene’s variant(s), minimum PROVEAN score of the gene’s variant(s), binary prediction (neutral or deleterious) of this PROVEAN score, and presence in a linkage region (see Fig. 2). The LR.PFS3 model  was not used in the ranking since it is not defined for indels.