It has been recognized recently that several B-cell neoplasms, such as diffuse large B-cell lymphoma (DLBCL), LYG, and some forms of Hodgkin lymphomas are EBV-related . According to Castillo, et al., DLBCL in the elderly has 100% EBER expression, and DLBCL associated with chronic inflammation, as well as 3-10% of DLBCL cases not otherwise specified, is related to EBV infection . LYG lesions at Stage II and III have 100% EBER expression by definition . Endemic type Burkitt’s lymphoma is also positive for EBV infection . Most of these disorders result from the relapse of dormant EBV secondary to acquired or congenital immunodeficiency status.