Methods summary. Whole exome sequencing and variant calling was performed for each individual in both families. For each family, genes are selected that have at least one variant with a high or moderate variant impact, that differ between healthy and affected PKP2 carriers, that have a coverage of at least 10X, and that are expressed in the heart. These genes are filtered to include only genes related to ACM or PKP2 and are computationally prioritized. Results are presented in Table 2