Fig. 1: the 3′ UTR of Dengue virus (DENV) RNA contains target sequences for cellular miR-484 and miR-744. (A) Alignment of a fragment of the 3′ UTR of the four DENV serotypes. The miR-484 and miR-744 target sites common to the four serotypes are indicated; (B) the target sites for miR-484 and miR-744 fulfil the seed sequence (shaded nucleotides, first nucleotides from the 5′ end of the miRNA). Structures predicted using RNAhybrid; (C) location of the miR-484 and miR-744 target sequences in the 3′-SL, CS, and 3′UAR regions of the 3′ UTR. The secondary structure of DENV RNA was predicted using the Mfold program (Zuker 2003). The sequences and position numbers in (B) and (C) correspond to DENV-1 RNA.