The promising properties of GO with its flat two dimensional structure and the availability of functional groups with the potential of gelation and strong covalent interactions led us to explored the formation of 3D GO networks synthesised via crosslinking, using three different cations (Ca 2+, Zn2+ and Sr2+) at three different temperatures to expand the repertoire in biomedical applications. This approach will enable the inclusion of zinc and strontium in the matrix networks, which impart antibacterial properties to biomedical composites especially where surface contamination is a potential hazard. Additionally the presence of ions such as strontium and zinc are also known to accelerate bone healing and possess antibacterial properties, thus the incorporation of these ionic species within scaffolds for bone regeneration is of significance.