Recently studies on application of CMA for various fetal anomalies have also been published. It has been strongly suggested by the early onset of these neoplasms and their embryonal appearance that prenatal factors are important, especially genetic factors. So CMA was performed after fetal chromosomal karyotype analysis was normal. A 0.72-Mb duplication at 4q35.2 was detected in fetus which was associated with epilepsy. It is consistent with the fact that epilepsy is the most common symptom for intracranial neuroepithelial tumor. The CMA also revealed a 0.13-Mb deletion at 6q26 located inside PARK2 gene, and the PARK2 gene mutation has involvement in autosomal recessive juvenile Parkinson disease. The clinical phenotypes of this disease included shaking palsy, slow moving and myodystony, and so on. However, the microduplication at 4q35.2 and the microdeletion at 6q26 were still defined as being of uncertain clinical significance.