Factor V deficiency (F5D) is a rare hematological disorder with an estimated incidence of 1 case per million people. Until now, more than 200 cases have been recorded worldwide in the literature. F5D patients present with various clinical manifestations. Although mucosal bleeding is the most common, fatal bleeding complications are also possible. Thus, F5D increases the difficulty of invasive testing, and surgical and procedural treatments. When long-term antithrombotic drugs, including antiplatelet agents and anticoagulants, are required in patients at high risk of bleeding, one of the biggest challenges is coronary intervention to treat coronary artery disease. Most studies recommend preinterventional or preoperative supplementation with fresh frozen plasma (FFP) to reduce bleeding risk. However, in addition to the bleeding risk caused by antithrombotic therapy, the hypercoagulable state in coronary intervention has an adverse effect on stent thrombosis, mortality, and prognosis during the postinterventional period. The contemporary standard therapy for significant coronary artery stenosis is implanting a drug-eluting stent (DES). However, because implanting a DES delays endothelial healing and requires long-term antithrombotic therapy, DES implantation in an F5D patient is very complex. No antithrombotic therapy study to date has been reported for F5D patients undergoing coronary stenting. Herein, we report a case of an F5D patient who underwent coronary stenting in the absence of an FFP transfusion and who received successful maintenance therapy using a single antiplatelet agent with recurrent multiple mucosal bleeding events after coronary stenting.