We performed a Pearson correlation analysis to discover genes that were associated with CBX7 in CGGA, Rembrandt and GSE16011 datasets (R > 0.4). To clarify the associations between these genes and specific GO functional categories, DAVID Web tool (http://david.abcc.ncifcrf.gov/home.jsp) and KEGG pathway analysis were used. In total 594 upregulated genes and 579 downregulated genes were identified (Figure 2A). As is shown in Figure 2B, decreased gene expression profiles were more enriched in pathways related to cell cycle and cancer signaling pathways. Furthermore, GO enrichment analysis also showed that these downregulated genes were strongly enriched in the cell cycle regulation process (Figure 2C). The in silico prediction of CBX7 function was in line with tumor-associated phenotypes.