From the morphological results, we observed that there was no standardization of myointimal hyperplasia, as in some animals, hyperplasia occurred only in the intimate layer characterized by its elevation with invasion to the vessel lumen and the presence of foam cells without muscle invasion and other animals with muscle invasion (Figure 5A). Some animals showed changes only in the muscle layer (middle), and the arterial intimal layer was spared; these changes were characterized by calcium deposition at different levels (Figure 5B). Considering the immunohistochemical analysis with the HHF35 monoclonal antibody for the muscle cells, there was also no myointimal hyperplasia pattern, because we observed that the animals had hyperplasia with muscle invasion or muscle metaplasia in the intimate vascular network (Figure 3A), as well as no muscle change (Figure 3B).