The multiscale biomechanical model proposed by Vavourakis et al.  simulates the wound healing process taking as input the volume excised during surgery. This volume depends on the tumor position and size, and therefore, a virtual surgery has to occur in which all FE inside the volume to excise are re-labelled as damaged and assigned with different physiological and mechanical parameters. In , this virtual surgery is simulated in the supine position: the surgeon identifies the tumor position, defines the incision lines and outlines the incision path inside the breast. The excision volume is then approximated by a cylinder that contains the lesion and whose axis is perpendicular to the chest-wall, extending from the skin to the pectoral muscle. All FE contained inside this cylinder are assigned with damaged tissue properties.