We propose a new medical model that has been described to be based on the concept of holistic medicine, in which biological, psychological, social and environmental aspects of the health-disease process are taken into account in the recommendation of a revised lifestyle. Through allostasis, the autonomic nervous system, the hypothalamic-pituitary-adrenal axis, the cardiovascular system, the immune system, the endocrine system and metabolism protect the body by preparing these systems to address both internal and external stress. This concept of allostasis complements the concept of stress. Allostasis represents the active adaptation process involving the production of mediators such as adrenal steroids, catecholamines, cytokines, neurotransmitters and other factors. After suffering chronic stress, adaptation responses or allostatic responses are initiated in the body. Inadequate or excessive responses following repeated stressful situations lead to allostatic load, which is the “price paid by the organism” for being forced to adapt to psychosocial or physical adversity. Thus, allostatic load constitutes the cumulative wear and tear resulting from chronic hyperactivity as an adaptation to the constant demands of life. The response to stress is physical, mental and behavioral and depends on basic personality as well as social, cultural, environmental and genetic factors. A new medical paradigm of health promotion and disease prevention is very important, as this paradigm supports lifestyle changes that increase resilience to stress and augment immune system defenses .