To further investigate the role of DHX29 in antiviral immune response and clarify the discrepancy between our data and those using human lung airway epithelial cells  on the specificity of antiviral immunity against EMCV and VSV, we examined whether the extent of DHX29 expression can modulate EMCV and VSV infection. The mRNA level and titer of EMCV, but not VSV, were significantly reduced in DHX29 stably transfected (mDHX29) mouse embryonic fibroblasts (MEFs), when compared with empty vector-transduced MEFs (Fig 4A). Conversely, mRNA and titer of EMCV, but not VSV, were dramatically increased in DHX29 siRNA-transfected MEFs in comparison to scrambled siRNA-transfected MEFs (Fig 4B). Our results suggest that the expression level of DHX29 can specifically modulate the infection ability of EMCV.