To date, very few data are available regarding virological response of patients displaying E157Q-mutated virus, only represented by case reports that limit their interpretation. In the study of Ambrosioni et al., only two cART-naïve patients initiated a DTG-based regimen with a very short follow-up of 12 weeks . In the study of Pavkovich et al., only six among the 15 patients initiating an INI-based regimen were in virological success at month 12; however heterogeneous profiles of patients, cART-naïve and cART-experienced, were mixed in the analysis .