Recently, BRAFV600E-associated mRNA signature was determined in a mouse model and human samples24, which identified new genes not previously reported as related to BRAF mutation in thyroid cancer (e.g. MMD, ITPR3, AACS, LAD1, PVRL3, ALDH3B1, and RASA1) that will provide further support for future research on BRAF-induced PTC24. However, this analysis did not evaluate the expression of long noncoding RNAs (lncRNAs), which are progressively shown to be of fundamental importance in other types of cancer25, 26. Such analysis is necessary for the identification of BRAFV600E-correlated long noncoding RNAs.