In both humans and mice, the VPS13 family comprises four members (A–D), with VPS13A and VPS13C showing the most similarity to the yeast homolog (73). All four proteins are large and have potential functions in membrane protein trafficking, Golgi structure, and/or phosphatidylinositol metabolism (37, 47, 53, 62, 63, 73). Mutations in VPS13A and VPS13B cause the genetic diseases chorea-acanthocytosis (ChAc) and Cohen syndrome, respectively (32, 53, 71), and a loss of VPS13C function has recently been linked to early-onset Parkinson's disease (35).