A total of 200 participants in the standard care arm and 200 participants in the community-level prophylaxis arm will be enrolled in the resistance sub-study. Three stool samples will be collected from each participant, at days 0, 7, and 28 using standard operating procedures (SOPs) developed for stool sample collection in Niger. Samples from day 0 in the community-level prophylaxis arm will be collected prior to distribution of ciprofloxacin.