Activation of stress responses can induce diverse physiological changes, including modulation of cell cycle progression and remodeling of cell wall architecture23–27. The most well characterized stress response pathway involved in cell cycle regulation is controlled by the MAP kinase Hog126. In response to osmotic stress, Hog1 mediates a transient cell cycle arrest to enable cellular adaptation26. Multiple stress response pathways coordinate cell wall remodeling in response to environmental perturbations, including heat shock27, osmotic stress28, and cell wall stress29. However, little is known about whether cell cycle progression and cell wall remodeling are coordinated in response to stress in C. albicans, and whether there is a central signaling pathway that integrates these fundamental aspects of cellular biology.