Whole genomic DNA was isolated from cell lines using the GenElute Mammalian Genomic DNA Miniprep Kit (Sigma-Aldrich). DNA was processed for high-resolution methyl-seq by the NextGen Sequencing Core at the Norris Comprehensive Cancer Center. Whole genome sequencing was done on an Illumina NextSeq and each library sequenced with paired-end runs for 150-bp read length analysis.