Indirect validated targets of the DE lncRNAs were loaded into the Database for Annotation, Visualization and Integrated Discovery (DAVID)57, which returned the gene ontology of the query genes and identified enriched Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways58. miRSystem59 was used to calculate enriched pathways based on the predicted targets of the query microRNAs, which in this case, were the DE microRNAs in both conditions (Normal × Tumor and WT × BRAFV600E). For protein-protein interaction network it was used Genemania60.