This latter feature has potentially both an economic and environmental impact, deriving from a lower consumption of organic solvents, as lowering the E-factor in a process is a must for the modern chemical industry. Despite these many advantages, nanoreactors have not yet found widespread use in industry. A number of reasons can account for this. First of all, the construction of the nanoreactors is not always a cost-efficient process. Scalability and reproducibility in nanoreactor production also are key factors that have to be addressed. The recyclability and cost price should be improved to allow competition with existing heterogeneous and homogeneous processes. Furthermore, in most cases only model reactions have been studied. The improvement of a process that is highly relevant for industry would aid in a further acceptance of this technology by the end users. Another issue is that the specific characteristics of nanoreactors should be employed more effectively. Physical protection and separation of catalytic species will allow the performance of multistep conversions in one-pot reactors. This would then enable continuous flow processing, as intermediate work-up steps and solvent switching procedures can be prevented. Although this requires still much development, it is to be expected that in the near future nanoreactors will be key to a more sustainable production of fine chemicals.