Maize is the most important staple crop in Mexico, where a variety of maize types and production systems are present. Currently, in-country maize production is not sufficient to meet internal demand (Turrent Fernández et al. 2012; Blanco et al. 2014). Maize production is highly technified in Northern Mexico, and yield potentials are similar to those observed in the US Corn Belt (Turrent Fernández et al. 2012). Higher yields in Northern Mexico are associated with the use of improved conventional maize hybrids, irrigation, fertilizers, and appropriate crop management (e.g., weed and insect control). The use of pesticides in Mexico is the highest (4.5 kg ha−1) in North America (Stokstad 2013). Recent reports have documented the need and potential benefits of adopting IPM programs and newer, more sustainable technologies in corn production in Mexico (Bell et al. 2012; Blanco et al. 2014). IPM programs would minimize economic losses and would lower environmental and health risks. Once approved, GM maize potentially offers an additional tool for Mexican farmers for insect and/or weed control, increasing yields while reducing the number of insecticide applications.