Colorectal cancer, as a common malignancy in the world, has accounted for the second and third of cancer related death in male and female respectively . Though the patients with early colorectal cancer reach satisfied survival, the advanced ones always own poor survival attributed to unresectable primary tumor, resistance and recurrence [2–4]. Thus, it is necessary to search for efficacious markers to assess the prognosis of colorectal cancer, especially in advanced stage.