We hypothesized that multimorbidity scores’ impact on HRQoL was different according age and gender. Significant interactions between age groups and multimorbidity scores and between gender and multimorbidity scores confirmed this hypothesis. So multiple linear regression used to examine the association between multimorbidity and HRQoL scores (PCS and Phys; MCS and Ment) were realized for each age group and by gender. Models were adjusted for others sociodemographic variables which p<0.2 in bivariate analyses. Analyses involved use of SAS 9.4. Two-sided p < 0.001 was considered statistically significant (after Bonferroni correction).