In China’s Sichuan Province on May 7, 2014, the first-ever fatal case of human infection by a reassortant H5N6 AIV involved a 49-year-old man with a history of exposure to live poultry. To date, 14 additional cases of human infection with the H5N6 virus in China’s Sichuan, Guangdong, Jiangxi, and Yunnan Provinces—10 of which ended in death—documented by the World Health Organization and World Organisation for Animal Health were characterized as posing a potential risk to public health1.