An IRD produced an increase of SBP in the mean of the SBP peaks during the 40 repetitions in comparison with a CD, due to the lack of the v-shape advantage during the former. The increase in SBP was predictable with a mixed linear model during the first set of the CD, with a progressive increase once the nadir was reached during the third repetition. While none of the designs may help to have the actual lowest pressure response possible, these study findings will help to better control the SBP response during a set in resistance exercise.