Clinical significance of this cut-off value was further tested by contingency analysis of haemodynamics, clinical characteristics and fibrinogen plasma concentrations. Fibrinogen plasma concentrations above 3.65 g/l were strongly associated with unfavourable haemodynamic parameters including mPAP (p = 0.001), PVR (p = 0.004), RAP (p = 0.007) and central venous oxygen saturation (SvO2, p = 0.006). Furthermore, a fibrinogen concentration >3.65 g/l was also linked with elevated CRP concentrations (p = 0.023, Table 4).