Micorotubules are composed of α- and β-tubulin heterodimers and are present throughout neuronal dendrites and axons. Microtubule dynamics regulate axonal outgrowth, dendritic spine morphology, and synaptic plasticity . Treatment with paclitaxel, a microtubule dynamics inhibitor, leads to LTP deficits in the cortico-amygdala pathway in mouse brain slices . Actin exists in both monomeric (G-actin) and polymerized (F-actin) forms and presents in dendritic spines. Actin dynamics are essential in synaptic function and memory formation . Indeed, cytochalasin D, an inhibitor of F-actin polymerization, blocks the late phase of LTP but not the early phase . Thus, changes in the expression of tubulin and actin might affect synaptic plasticity, being involved with diabetes-induced dementia.