In our study, we used a comprehensive gene expression profiling by means of microarray analysis to identify clusters of genes differentially expressed in peripheral blood cells, taking into consideration the kinetic of the response with 4 time points (t∈{0,+1,+4,+24}). LPS induces dramatic changes in blood cell number and lymphocyte/granulocyte (L/G) ratio that introduces a confusion between time and cell type effects, and a major challenge for the interpretation of transcriptomic data. Therefore we based the interpretation of the results on three different lists of genes, (List1), (List2), and (List3).