As many studies have reported, MMPs play a predominant role in the process of tumour cell intravasation, and the dynamic interplay between N-cadherin and epidermal growth factor receptor (EGFR) leads to MMPs gene transcription . As shown in our data, the expression of N-cadherin and MMPs was increased in PLC-GRN/RBE-GRN cells; therefore, we speculated that the level of MMPs was increased under the action of the N-cadherin and EGFR through stimulation by CsGRN, eventually leading to the degradation of basement membranes and metastasis.