In this study, we report for the first time a significant association between HLA-B∗35:08 and LTG-induced CADR or MPE, although this allele has been reported in only one case of LTG-induced MPE and once in the general population, as a result of this allele being very rare in the Thai population (less than 1%, data from Puangpetch et al., 2015). The interpretation of data from studies with a small sample size can only be tentative, and further investigations with larger sample sizes are needed. Similarly to HLA-B∗35:08, the association of LTG-induced MPE and HLA-B∗44:03 alleles was firstly reported in the Thai population. One recent study from Korea found that HLA-B∗44:03 was associated with LTG-induced SJS/TEN (OR: 12.75, 95% CI: 1.03–157.14, and P-value = 0.053) (Park et al., 2016).