These principles cover five areas: the public release of data and other scientific resources; external research partnerships; the MNI Biobank; researcher and patient autonomy; and intellectual property. The authors developed draft Guiding Principles based on the results of this study. This draft was then presented to the MNI staff, management and researchers, who reviewed and amended the draft during two rounds of discussion and feedback. These Guiding Principles were adopted by the MNI in December 2016.