Targeted therapy for oncogene has been an emerging therapeutic method in recent years, whereas patient survival rate has not been improved due to late detection and therapy. Thus it was essential to find cancer marker guidance of early discovery, diagnosis and treatment, which led to biomarker becoming one of the most valuable area in cancer research. NSCLC is hardly characterized by one marker for heterogeneous disorder with a variety of biomarker , making it hard to find effective NSCLC marker.