The residues of HER2 that have closer interactions with the ligands are highlighted in different colored circles based on the type of interactions such as hydrogen bonds, Van der Waals forces, ionic bonds. These were the residues responsible for the ligand-HER2 interactions respectively. All these interacting residues for all the ligands are identified and the common interacting residues are obtained to figure out the pharmacophore / functional interacting pattern. To obtain this, the ligands are grouped into three categories: the first five of the commercial drugs, the next three - the most potent commercial drugs and lastly, the isolated compounds from Sponge, namely Stigmasterol and Oleic acid. For all the three groups, their respective binding site residues are identified. Then a Venn diagram has been drawn, which is as shown in Figure 3.