In IHC, the patients were divided into EpCAM low (n=123, 32.6%) and high (n=254, 67.4%) expression groups. EpCAM high expression significantly had something to do with to age >60 years (p<0.001), upper parts of stomach (p=0.040), macroscopic type III (p=0.020), tumor size >7cm (p=0.002), T3 stage (p=0.017), N2-3 stage (p=0.019) and TNM III stage (p=0.004). Multivariate analysis showed that age (p=0.001, OR=1.619, 95%CI [1.204-2.178]) and tumor size (p=0.008, OR=1.492, 95%CI [1.109-2.008]) were independent related factors to EpCAM expression.