The second network (NW2) is related to cell death and survival, cellular development, cellular growth and proliferation. The NR3C1 (nuclear receptor subfamily 3, group C, member 1) gene encodes the glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes, and as a regulator of other transcription factors. Signal transducer and activated transcription 1 (STAT1) has been identified as a point of convergence for the cross talk between the pro-inflammatory cytokine interferon γ (IFNγ) and the Toll-like receptor-4 (TLR4) ligand LPS in immune cells . LPS activates STAT1 via the NF-κB pathway .