Metformin treatment in the high-sodium treated animals had no influence on the pattern of hemodynamic changes: neither MAP, circadian dipping, nor heart rate differed between vehicle- and metformin-treated groups (Figures 2C,D,F). During the experiment, sodium and potassium urinary excretion, plasma glucose level (Figure 3A) as well as total body weight at the end of the experiment (303.8 ± 12.5 vs. 309.6 ± 13.8 g) did not differ between the groups.