This issue is further complicated when an indolent tumor, such as NIFTP, should be resected according to current ATA guidelines. NIFTP is commonly associated with RAS mutations (8/27, 29.6%) and its diagnosis is incompatible with the presence of BRAF V600E mutations (70, 79). Moreover, Nikiforov et al. describe that 22% (6/27) of NIFTP samples harbor no detectable mutations. To conform to the recommendation that this indolent lesion be resected, new validation studies must show the reliable identification of NIFTP by molecular markers, an unlikely occurrence given the fact that benign lesions also harbor them.