The Dahl salt-sensitive rat strain is a well-established model for studies of the NaCl-dependent type of hypertension. This model recapitulates many traits of the human form of salt-sensitive hypertension: suppressed plasma renin activity, lower circulating aldosterone concentration, increased vascular resistance, impaired pressure-natriuresis response, and decreased venous compliance (Rapp, 1982; Rapp et al., 1989; Sullivan, 1991; Cowley, 1997; Hall, 2016). A hallmark of Dahl SS rats is the rapid progression of hypertension in response to high-NaCl diet. Typical experimental protocols utilizing 4 or 8% NaCl chow induce a substantial rise in blood pressure (BP) within 2–3 weeks after the change of diet.