We also tested if there is a difference in Pv ranks for SNPs from the lowest 100th centile of the Pm rank-ordered distribution for all five traits and the rest of SNPs in the pruned set of SNPs using the Mann–Whitney U test, including and excluding established SNPs (or SNPs that were +/-500kb from the reported lead SNP). This analysis was repeated for SNPs from the 99th centile vs SNPs from 1st to 98th centiles of the Pm rank-ordered distribution. The same Mann–Whitney U tests were used to study differences in Pm ranks for SNPs from the lowest 100th and 99th centiles of the Pv rank-ordered distribution and the rest of SNPs in the pruned set of SNPs.