It is widely acknowledged that “the best solvent is no solvent”; however, running a reaction under neat conditions is very challenging from the points of view of mass transfer and temperature gradients [1–2]. Therefore, sustainable chemical technologies are often related to the use of a green non-harmful solvent , water. In principle, green chemistry refers to (1) the employment of raw material (substrates) in an efficient manner, (2) decreasing the resulting waste or undesired byproducts, and (3) using cheap and environment friendly solvents (i.e., water). Generally, using water as a solvent is an acceptable choice for green chemistry [4–6]. Indeed, water is attractive from both economic and environmental points of view, and is not taken into account when the E-factor (defined as mass ratio of waste to desired product) for a chemical process is determined [7–8]. This is to be true for chemical processes where the utility of water is limited to the work-up at the end of the process and not when used as a reaction medium. However, it should be noted that the utility of water as a reaction medium is the safest, but not the greenest choice. Unfortunately, most organic compounds and catalysts are not soluble in water, limiting its utility for most reactions [9–10]. For this reason, scientists across academia and industry have proposed many solutions in order to maximize the outcome of reactions (i.e., yields, enantioselectivities, etc.) in water and, thereby, harness its utility for further applications. The abovementioned issues are particularly relevant in the field of asymmetric catalysis, which besides overcoming catalyst compatibility also has to deal with cost issues [11–12]. Research on asymmetric catalysis has been mainly focused on performing catalytic reactions with high enantioselectivity and efficiency [13–14]. As a result, a wide range of chiral catalysts have been established [15–16]. Chiral catalysts are, however, not only incompatible with aqueous solutions, but also expensive due to the structural complexity of the ligands used and the usage of transition metals. Finding an approach to utilize chiral catalysts in water while minimizing their cost (i.e., recycling) is still a big challenge. In order to accomplish this, various strategies have been proposed and applied [17–19]. One significant, well-established and widely used strategy, is the use of site-isolated techniques, i.e., creating a separate micro environment [20–22] for catalysts to (1) allow their use in incompatible media, (2) to reduce their costs by recycling them, and (3) avoid any unfavorable environmental influences that might affect reaction yield and output [23–24]. Indeed, such a strategy proved to be advantageous for performing reactions in water and minimizing both reaction waste and cost [25–26].