Results are presented as mean ± SEM. Metabolic parameters denoted with superscript a, were analysed on log-transformed data (due to non-normal distribution), and are consequently presented as geometric means with 95% confidence intervals. Superscripts (*,#,†,‡) indicate significant (p < 0.05) differences in readouts compared to Control-, NASH-, HFD- and HFr-groups respectively. Sample sizes at week 16: n = 6–10/group. b Fasting plasma glucose and fasting plasma insulin levels were assessed after 15 weeks