As we know, the disease is often caused by complicated factors. This study observed that CsGRN, as a CsESP like CsCBs and Csseverin, has also been shown to promote cell migration and invasion. In consideration of the complex constitution of CsESPs, including proteases, antioxidant enzymes and metabolic enzymes [24, 50], interactions among these components are required to determine the authentic factors for pathogenesis in the future. We will explore the actions of granulin members with one or more typical domains in C. sinensis to clarify the difference between these molecules in our further studies.