Pazopanib was purchased from GlaxoSmithKline (GSK). Bis-benzimide was purchased from Life Technology (Carlsbad, CA). Anti-VEGFR2 (FLK) was purchased from Santa Cruz Biotech. (Santa Cruz, CA). Anti-Cleaved Caspase3, anti-Meca32, Anti-Akt, anti-Phospho-Akt (Ser473), anti-Erk, anti-Phospho-Erk and anti-GAPDH were purchased from Cell Signaling Technology (Beverly, MA). Protein G Sepharose beads were purchased from GE Health Biosciences GE Healthcare (Piscataway, NJ). [14C-methylcholine] sphingomyelin was purchased from Amersham Biosciences (Piscataway, NJ).