Other promising steroidal pyrimidines were discussed by Ali et al. (2017). The antitumor activity of the B-ring fused steroidal pyrimidines was tested in vitro against the MDA-MB231, HeLa, and HepG2 cancer cell lines and the non-cancer normal cell line PBMCs (peripheral blood mononuclear cells) by the standard MTT assay. The compounds showed moderate to good activity and proved to be nontoxic to normal PBM cells. One of the synthesized compounds was found to be active against all three cancer cell lines but more specific against the MDA-MB231 cells with IC50 of about 9 μM, which is similar to our data on the activity of the compounds against breast cancer cells. Finally, the authors discussed the ability of steroidal compounds to interact with the protein HSA involved in drug delivery.