An RM must be established to be fit for its intended use in measurement or in examination of nominal properties, sufficiently homogeneous and stable with respect to specified properties, and available long-term with consistent product quality attributes to serve as a sustainable industry standard. Property values may be assigned to a given RM through a variety of measurement modes, the results of which influence the value designation (certified, reference, or informational as described in) [10, 13]. A series of method-specific protocols, each of which has been recognized by the community as common measurement methods for mAbs, were qualified to be suitable for NISTmAb measurement in the preceding papers of this series using the in-house NISTmAb primary sample (PS 8670) [9–12]. The physicochemical property values were then assigned to each individual lot of RM 8671 using the qualified methods and a stratified sampling and analysis plan, thereby allowing simultaneous evaluation of intra-lot homogeneity. The following discussion also shows inter-lot homogeneity with respect to each property value through analysis of three lots of RM 8671. The consistent performance of each lot provides confidence that the designated process and lifecycle management plan will produce consistent product quality attributes for current and future lots of RM 8671.