This protocol was constructed to investigate the BPR. The fundamental patterns were designed by combining a pf/aa bursts with a SC burst (De Zeeuw et al., 2011; van Beugen et al., 2013; Valera et al., 2016). In a first design, excitatory synapses were randomly distributed over 100 dendrites, both from aa or pf. This allowed to obtain a 250 Hz PC burst as in Walter et al. (2009). The inhibitory burst was composed by three spikes with a 7 ms interspike interval (ISI). Inhibitory synapses were distributed over 25 dendrites and delayed by 4 ms with respect to the excitatory burst to account or synaptic delays along the afferent neuronal chain (granule cell to SC to PC; see also Ramakrishnan et al., 2016). Variants to this pattern were used to reproduce type I, II and III responses (De Zeeuw et al., 2011; Valera et al., 2016), to evaluate the impact of synaptic inhibition, to selectively activate aa rather than pf synapses, to change the intensity or frequency or duration of the bursts, to modify synaptic parameters like release probability and maximum conductance, to restrict pf/aa activity to specific dendritic sectors.