Concomitant radiochemotherapy (RChT) was given to 35 patients. The median age of patients receiving a combined treatment was 69.3 years (65.1-78.8). A better ECOG was significantly associated with the initiation of adjuvant chemotherapy (p <0.001) as well as with the decision for a combined modality treatment (p <0.001). Patients receiving combined treatment generally were in a good performance status (median ECOG of 1; 0–2). All these patients received a standard fractionation regimen with single doses from 1.8 to 2.0 Gy up to a median dose of 60.0 Gy. MGMT promotor methylation was examined in 23 cases and was positive in 11 of these cases (47.8%). 1 to 9 cycles of adjuvant chemotherapy with temozolomide were given to the majority of these patients (26 of 35 patients; median No. of cycles 6) and were tolerated well. In 3 cases decision against adjuvant treatment was due to a poor performance status. Also in 3 cases, early progression occurred after RChT; one patient underwent salvage treatment, two patients were included into a best supportive care program. Two patients with severe infection during RChT decided against further chemotherapy. One patient underwent revision surgery for symptomatic radionecrosis, therefore adjuvant chemotherapy started with a delay of 3 months and the patient was not included into the adjuvant ChT group.