Data from 149 patients are included in this analysis (Table 1) because one patient died from massive PE before completion of the procedure. Fifteen patients (10%) developed 17 major bleeding complications, defined as GUSTO severe/life-threatening and moderate bleeding events (Table 2). None suffered ICH. GUSTO mild bleeding was observed in 20% of patients. GUSTO mild bleeding was observed in 15 (14%) patients with submassive PE and six (25%) of those with massive PE (p=0.21).