The neuroinflammatory reaction. Coronal brain sections, prepared at the level of the hippocampus, and stained with haematoxylin and eosin were employed to assess the neuroinflammatory reaction in uninfected mice (A) and mice infected with T.b.brucei. Inflammatory cells can be seen infiltrating the meninges (blue arrows) of the cerebral cortex on day 14 post-infection (B) and are most abundant at day 21 (C) and 28 (D) post-infection. Inserts show the development of mild perivascular cuffing of the vessels in the hippocampal fissure (black arrows) on days 21 (C) and 28 (D) post-infection. (magnification; ×200, calibration bar (20 µm) shown in panel D).