The aim of this study was to assess the socio-demographic factors influencing Acehnese inhabitants’ view related to vaccine. A cross-sectional survey was conducted during Nov 2014 to Mar 2015 and Aug to Dec 2015 in 11 regencies of Aceh. A set of validated questionnaires was used to assist the interviews. To elicit the view related to vaccine, two questions regarding the importance of the vaccines to prevent diseases and the safety of the vaccines for children were asked with responses on a Likert-type scale ranging from “1=strongly disagree” to “5=strongly agree”. The view related to vaccine was dichotomized into “good” and “poor” based on an 80% cut-off point. A logistic regression analysis was employed to analysis the data.