We aimed to test the possibility of finding a threshold value that would distinguish patients with a higher or lower probability of relapse or CDP (the “value” in Figs. 1-4). More importantly, we aimed to measure changes in lymphocyte subpopulations longitudinally in each patient separately so that the disease course could be predicted. Therefore, we tested the ratio of current values versus values obtained a year before compared to baseline (Ratio vs. LY and Ratio vs. BL Figs. 1-4).Fig. 11) ROC curves of CD19+ B lymphocytes to predict relapse at one year. AUC for the population relative value = 0.505, AUC for the population relative value change compared to baseline = 0.513, AUC for the population relative value change compared to a measurement one year before = 0.495. 2) Survival curves and asymptotic log-rank tests for groups divided by the threshold