The capacity to coordinate cell cycle progression with stress responses is crucial for cellular survival to give cells time to recover from a myriad of environmental perturbations, including cell wall stress49. In the present work, we uncovered a dual role for the transcription factor Cas5 in mediating cell cycle dynamics and cell wall stress responses in C. albicans (Fig. 10). We discovered that RNA PolII binding to many genes important for cell wall biosynthesis and DNA replication is dependent on Cas5 under basal conditions (Fig. 1). We also found Cas5 regulates the expression of a distinct set of cell wall and cell cycle genes in response to cell wall stress (Fig. 2). We established Cas5 function is regulated by the protein phosphatase Glc7 (Fig. 7), and Cas5 functions in concert with Swi4 and Swi6 to regulate cell wall homeostasis (Fig. 8). Our findings implicate Cas5 at the core of a novel mechanism by which cell cycle and cell wall integrity are coordinately regulated.Fig. 10Model for Cas5-mediated coupling of cell cycle progression to cell wall stress response. Cas5 is dephosphorylated by the protein phosphatase Glc7 in response to cell wall stress. Once dephosphorylated, it can translocate to the nucleus to govern the expression of a myriad of genes, including those important for cell cycle regulation and cell wall stress response. Cas5 regulates changes in gene expression through both Swi4/Swi6-dependent and independent mechanisms