Illustration of the predominant species of complex sphingolipid in organisms from different evolutionary clades: EPC in Drosophila; SM in mammals; and IPC in Leishmania and T. cruzi (as representatives of protozoan parasites) and in fungi and plants. IPC is absent from Mammalian cells but essential for many pathogenic organisms (red box). Glycosylated sphingolipids are also ubiquitous across different species. Backbone chain length is commonly C18 derived from palmitoyl-CoA. Mammals M, Fungi and Plants FP, Leishmania spp. L, Trypanosoma cruzi Tc, Trypanosoma brucei Tb, Toxoplasma gondii Tg and Plasmodium falciparum Pf. *Denotes developmental regulation. EPC, ethanolamine phosphorylceramide; IPC, inositol phosphorylceramide; SM, sphingomyelin.