This work was originally inspired and applied in a radionuclides resistance study. Genome sequences of several radiation-resistant microorganisms can be used for comparative genomics to infer the similarities and differences among those species. Homology inference is important to identify genes shared by different species and, as a consequence, species-specific genes can be inferred. Two experiments are considered in this work. The input data for Experiment 1 was composed of 11 bacterial genome protein sequences, 10 of these are radiation-resistant (Kineococcus radiotolerans - Accession Number NC_009660.1, Desulfovibrio desulfuricans - NC_011883.1, Desulfovibrio vulgaris - NC_002937.3, Rhodobacter sphaeroides - NC_009429.1, Escherichia coli - NC_000913.3, Deinococcus radiodurans - NC_001263.1, Desulfovibrio fructosivorans - NZ_AECZ01000069.1, Shewanella oneidensis - NC_004349.1, Geobacter sulfurreducens - NC_002939.5, Deinococcs geothermalis - NC_008010.2, Geobacter metallireducens - NC_007517.1) for Reciprocal-Best-Hit (RBH) processing.