In patients with a rise in serum creatinine, higher baseline plasma NGAL (p for interaction 0.024)—but not higher baseline serum creatinine (p for interaction = 0.464)—posed a significant, relatively greater risk of reaching the 60-day composite endpoint. Supplementary Figure S5 displays the multivariable hazard ratios for the 60-day composite endpoint for the continuous interactions between creatinine change, and baseline values of creatinine or NGAL. The continuous hazard functions for creatinine change, stratified by either baseline creatinine levels (first panel) or baseline NGAL levels (second panel), illustrate the interaction between creatinine change and baseline biomarker levels. Patterns were similar for the 180-day mortality endpoint, but no interactions reached significance.