In line with functional roles of this protein in translation, overexpression of Sbp1 rescues the defect in nonsense suppression caused by SUP35 mutant (Zadorsky et al. 2015). Furthermore, in a study on RNA-binding protein FUS/TLS-dependent cytotoxicity that causes a subset of familial amyotrophic lateral sclerosis (fALS) using yeast as a model system, overexpression of Sbp1 rescues the toxicity caused by FUS/TLS mutations (Ju et al. 2011).