EETC significantly suppressed growth of DPB and DPB-mediated periodontal disease. Antibiotics are used to both treat and prevent bacterial infections . Antibiotics like penicillin and erythromycin used to be highly effective against many bacterial species and strains. They are now less effective because these organisms have developed increased resistance to the drugs . Dental plaque, which adheres to the gingival sulcus, consists mainly of bacterial cells, salivary polymers, and bacterial extracellular products. Bacterial LPS stimulates the host cells, including macrophages, fibroblasts, and epithelial cells, which abundantly produce cytokines, thereby triggering a direct or an indirect immune response through inflammatory processes . The growth of bacterial biofilms increases antibiotic resistance and has been implicated in the etiopathogenesis of gingivitis and periodontal disease by inducing inflammation.