This regression parameter dataset is based on high-resolution T1 3D structural brain MR imaging data of 1919 healthy subjects aged 13–900 months [1–75 years]. Images were acquired at 1.5 and 3 T and were selected from four publicly available datasets (NIH, C-MIND, fCONN, and IXI). The dataset contains regression parameters from 6 DARTEL iterations for GM and WM each and can be used within the CerebroMatic toolbox to generate matched DARTEL/SHOOT templates for a researcher's own population.