The large enriched regions of rDNA or rDNA and telomeric repeats suggest that there are special mechanisms for the restriction of rDNA and telomeric repeat distribution along chromosomes in stick insects. However, chromosomes of M. extradentata are different. The chromosomes of this species are characterized by two large rDNA regions, but other chromosomes also contain many small clusters of rDNA and ITSs. These additional small clusters of rDNA are located mostly near the centromeric regions, while additional clusters of telomeric repeats appear close to the end of long arms. Some clusters of telomeric repeats are located very close to each other. Also, in the FISH results they look almost like fused dots. Other clusters are separated by regions of assorted sizes, suggesting inversion-transferred telomeric repeats in more proximal positions. There are also ITSs inside the chromosomes. Two different mechanisms of ITS formation are known. One of them suggests chromosome rearrangements involving telomeres. The second suggests repair of DNA damage by telomerase . Irregular distribution of ITSs along chromosome arms with a concentration near the chromosomal ends make us hypothesize that most of them are a result of chromosome rearrangements that took place during the chromosomal evolutionary history of M. extradentata.