Several other growth factors also play positive roles in tumor angiogenesis. MiRNAs have been reported to target these pro-angiogenic factors in tumor cells, such as FGF (miR-503 ), HDGF (miR-214 , miR-497 ), angiogenin (miR-409-3p ), angiopoietin (miR-204 ), and MMPs (miR-9 , miR-26b-5p , miR-98 , miR-181a-5p ). Moreover, some miRNAs were shown to simultaneously target more than one angiogenic factors. MiR-190 significantly suppressed tumor angiogenesis via targeting VEGF, HGF and IGF1, thus altering the local microenvironment and subsequently regulating neighboring ECs .