The present study involves six blood centers located in different regions of China (Fig. 1).Hopefully this study was therefore more representative. The aims of the present study were to evaluate the current prevalence, incidences and RR of HBV infections of blood donors among the six blood centers, and to provide guidance for developing and monitoring evidence-based blood donor management strategies to improve the safety of the blood supplies regarding the RR of TT-HBV infections.Fig. 1Geographic Distribution of the Six Blood Centers and the Institute of Blood Transfusion