Treatment before RLS, three aspects should be considered: lifestyle change, medication effect and iron deficiency (defined as ferritin < 75 ng/mL or iron/TIBC ratio < 20%) (Mackie and Winkelman, 2015). Lifestyle like sleep deprivation, alcohol or tobacco use, decreased motility, or in medication (dopamine antagonists, antihistamines or serotonergic antidepressants, opioid discontinuation or blood loss) can result in earlier onset or increase severity in RLS symptoms. A detailed inquiry for the patient should be carried out. Treatment of RLS mainly include pharmacological and non-pharmacological treatment.