This work strategy has been employed to avoid using crosslinkers agents and catalysts in order to incorporate the inorganic nanoparticles into the matrix; instead, we used the percolating approach to prepare the surface of cellulose fibers by the solvent-exchange method for effective facial interaction with inorganic particles of hydrophobic behavior, such as nanosilica, to design a new hybrid material of homogenous composition. The main feature of this work is to produce nanocomposites using cellulose as the matrix and not as the reinforcer of any other polymer, with no chemical modifications for interacting with inorganic nanoparticles, following a very facile and cost-effective method. This innovative method significantly reduces the complete synthesis time of the cellulose matrix composites from several days to only a few hours, since it comprises only one step of facile cellulose surface modification. On the other hand, the energy consumed during synthesis is very low and cost-effective, delivering a Trametes versicolor resistance cellulose-based hybrid composite with no antifungal agent added, thereby demonstrating low moisture absorption and high dimensional stability, that also shows improved thermal stability against pristine cellulose.