In the KPC mouse model, mice reliably generate aggressive primary tumors that invade adjacent tissues and sporadically metastasize: thus, morbidity and euthanasia result from the effects of either the primary tumor or its metastases. To ascertain whether mir-17~92 deletion differentially impacted primary versus metastatic disease processes, we stratified survival data based on the presence or absence of grossly visible metastases at euthanasia. The majority of KPC mice lacked metastases and were sacrificed at relatively young ages due to effects of the primary tumor (“localized” mice), whereas a minority presented later with metastatic disease (“metastatic mice”) (Figure 4C), suggesting that primary KPC tumors cause significant morbidity prior to the development of metastases. However, this was not observed in 17KPC mice, where localized and metastatic mice display similar survival curves (Figure 4D). Indeed, the survival of metastatic mice is not significantly different between KPC and 17KPC mice (data not shown), but the survival of localized KPC mice was significantly worse than that of localized 17KPC mice (Figure 4E). Moreover, localized 17KPC mice also possessed larger tumors than localized KPC mice (Figure 4F). Together, these data suggest that mir-17~92 contributes to the morbidity and mortality caused by primary KPC tumors and does not impact time to metastasis.