Two overview authors will independently assess the methodological quality of the included systematic reviews and meta-analyses using the ROBIS tool. A qualitative, domain-based assessment will be performed with ROBIS, evaluating eligibility criteria, identification and selection of primary studies, data collection and study appraisal, and synthesis and findings. A tabular presentation of ROBIS assessment for each included review will be provided and will enable comparisons between studies and detection of the possible presence of bias . We will also provide a table presenting a risk-of-bias assessment of primary studies and relevant tool utilized by each eligible review. If the risk of bias of primary studies has not been evaluated by one or more reviews, we will appraise these studies and present our assessment in a relevant table. The strength of evidence for each outcome of interest across the eligible systematic reviews will be evaluated by two independent authors using the GRADE rating [34–36]. In order to minimize the subjectivity of quality assessment process, a third reviewer will be involved to resolve any discrepancies.