We used the pair-wise Spearman rank test to correlate the amount of each relevant habitat in the tumor with the amount of necrotic, enhancing, non-enhancing, and edema regions within the tumor (Table 2). In particular, habitat 2 was also associated with necrosis (p = 0.0172). For habitat 7 and 10, there was no specific association with canonical tumor sub-volumes, suggesting the need for deeper examination of their physiology and molecular context.