On the basis of the studies available in the literature, we found that Allium sativum has beneficial effects such as anti-inflammatory, antioxidant, hypocholesterolemic, antitumoral, and anti-atherosclerotic actions, which prompted us to test its protective effect against myointimal hyperplasia. Our aim is to determine the mean difference of post-angioplasty myointimal hyperplasia in the external iliac artery of rabbits with induced atherosclerosis and treated with A. sativum compared with those treated with cilostazol, since the articles found in the literature demonstrate that cilostazol has effects of reducing the total cholesterol, triglyceride and phospholipids in serum, and moreover, the triglyceride content in the atherosclerotic arteries, so cilostazol significantly reduced the intimal atherosclerotic area.