The VPS13C/C2CD4A/C2CD4B locus was first associated with T2D and glycemic traits in GWAS published in 2010 (6, 15, 22, 29, 60). Subsequent studies identified further SNPs at this genomic location associated with poorer glycemic control and T2D (12, 67, 78). The above studies encompassed a range of distinct populations and age groups, thus providing confidence that SNPs in this locus, acting via either nearby or more remotely located genes, alter genetic susceptibility to T2D. SNPs within the VPS13C/C2CD4A/B locus have been linked to a range of glycemic parameters including higher fasting proinsulin (29, 67), higher 2-h glucose and lower 2-h insulin (60, 67), as well as increased fasting glucose (15, 22, 67) and increased waist circumference (22). Two studies also associated risk alleles with lower glucose-stimulated insulin secretion (GSIS) (6, 22, 67) and others with T2D (12, 67, 83). The “lead” (GWAS index) SNP in this locus, rs7172432, is in LD with a “functional” SNP, rs7163757, previously implicated by fine mapping as the most strongly associated (P = 3 × 10−19) SNP at this locus (61, 66). rs7163757 is located in an islet stretch enhancer (50, 61, 66), again suggesting that the disease-associated SNP acts on the expression of an effector gene(s) to alter diabetes risk.