Though our study provided a more convincing conclusion that D-dimer could act as a predictive biomarker of prognosis for colorectal cancer, some inevitable limitations should be discussed: 1) several included studies did not show the TNM stage or Dukes stages of colorectal cancer and it may cause the heterogeneity among the included patients and affect the application of this meta-analysis; 2) a study  with negative result was excluded due to unavailable data for meta-analysis which may lead to an exaggerated positive conclusion; 3) limited sample size of several included articles may give a underpowered HR, and thereby impact the pooled HR; 4) studies only in English or Chinese were included which may lead to incomplete evidence collection. Thus, a prospective study with a large sample to confirm the conclusion of this meta-analysis and cover the above limitations is indispensable.