It is clear that the burden PCa on the African continent has increased significantly over the recent years, with the highest mortality rates reported in sub-Saharan Africa . It has also been demonstrated that PCa incidence rates in African-American and West African populations differ, even though they share a common genetic ancestry [7, 9]. The bases for such disease disparities are largely unknown, and it has been difficult to develop state-of-the-art research on prostate tumorigenesis and biology in Sub-Saharan Africa. Barriers to knowledge about PCa in Sub-Saharan Africa include sociocultural issues such as poor funding [102, 103], insufficient manpower  and skilled health personnel , poor access to healthcare , religious and cultural beliefs , lack of well-updated cancer registries , poor research and healthcare infrastructure [102, 107], low educational level , prevalence of infection [109, 110], poor governance structures and fiscal policies . Although these factors are not unique to the African continent, the underlying genetic, hereditary and environmental basis of PCa aggressiveness in men of African descent still warrants further research.