In Cox models, baseline serum creatinine and plasma NGAL were invariably associated with both 180-day mortality and the 60-day composite (all p < 0.001), although this did not persist following multivariable adjustment (all p = n.s.). WRF was independently associated with both endpoints (multivariable HR for 180-day mortality: 1.45, 95% CI 1.12–1.88, p = 0.004; multivariable HR for the 60-day composite: 1.27, 95% CI 1.01–1.59, p = 0.04); sensitivity analyses with absolute creatinine change and other definitions for WRF showed similar performance (data not shown).