(a) Loop 1, 2, or 4 alone causes CODP while Loop 3 does not. (b) As Loop 1 is activated, M1 (red solid line) predominates over M2 (red dashed line). While Loop 4 is activated, both M1 (blue solid line) and M2 (blue dashed line) are relatively low. (c) In the case where Loop 1 is activated, Tg is predominant over T8 or T17. (d) The activation of Loop 4 leads to the predominance of T8 and T17 over Tg.