Antimicrobial selection depends on the suspected pathogen. For example, the drug of choice for cholera is tetracycline, though doxycycline, azithromycin, or ciprofloxacin may also be used. For typhoid, recommendations vary by geography (due to different resistance patterns). In Southeast Asia, for instance, the preferred drug is cefixime. For TD, in immunocompetent patients, the drug selected should at least cover Shigella spp., Salmonella spp., ETEC, and Campylobacter spp. Traditionally, ciprofloxacin and co-trimoxazole have been used, though there have been concerns recently over its side effects and development of resistance, respectively.