The HLA-A and HLA-B genotypes of the LTG-induced CADR patients are shown in Table 2. The HLA genotypes for the treatment tolerant controls and the comparison of the HLA allele found in the CADR patients and control groups (LTG-tolerant controls and general population) are shown in Supplementary Tables 1, 2. The HLA alleles that showed a significant association when compared with the tolerant controls and general population are presented in Table 3. We found the HLA-B∗15:02 allele in 40.0% of patients who developed CADR and in 12.0% of the tolerant patients. The proportion of patients carrying the HLA-B∗15:02 allele was significantly higher in LTG-induced CADR cases than in both the treatment controls and general population groups with odds ratios (OR) of 4.89, 95% CI = 1.28–18.66, P-value = 0.014 and OR = 3.63, 95% CI = 1.27–10.34, P-value = 0.027, respectively. In addition, we also found a significant association between LTG-induced CADR patients and both HLA-B∗35:08 and HLA-B∗39:01 when compared with the general population with OR = 70.36, 95% CI = 4.19–1182.21, P-value = 0.030 and OR = 10.68, 95% CI = 2.20–51.83, P-value = 0.022, respectively.