Ribavirin (MW 244.20) is a potent broad-spectrum antiviral drugs and now widely used for the prevention and treatment of viral diseases. It can be seen that there are peaks at m/z 245 and 113 in the Figure 5e. It can be confirmed that these ions corresponded to protonated molecular ion and major fragment ion, respectively, based on the results in previous literature . The fragment ion at m/z 113 for ribavirin analysis is due to the elimination of a stable 5-membered ring hydrofuran moiety. It was demonstrated that the MPT thermal desorption and ionization technology could achieve rapid and accurate qualitative analysis using only full-scan mass spectra data.