Furthermore, TCGA indicated that PARP1 was highly expressed in NSCLC, suggesting that PARP1 had a great influence on NSCLC. Coded protein in eukaryotic cells of PARP1 catalyzes poly-ADP-ribosylation and is involved in the process of DNA single-strand damage repair. The main achievement of PARP1 in cancer is stimulation for proliferation of colorectal cancerous cells, whereas there is no research on PARP1 functional mechanism in NSCLC.