Enactment of the NISTmAb RM 8671 quality plan is described herein, demonstrating identity, quality, and stability of this material with respect to its material properties. The NISTmAb represents a first-of-its-kind Reference Material intended for use in evaluating measurement technologies to inform on specific attributes during therapeutic protein characterization. With this unique role in mind, a novel lifecycle management plan was developed including a two-tier in-house reference standard system, industry-relevant concentration measurement, qualified physicochemical assays, and relevant informational measurements. RM 8671 was verified to be homogeneous both within and between vialing lots, demonstrating the robustness of the lifecycle management plan. It was analyzed in concert with the in-house primary sample PS 8670 to provide a historical link to this seminal material. RM 8671 was verified to be fit for its intended purpose as a technology innovation tool, external system suitability control, and cross-industry harmonization platform. The pre-competitive nature and long term availability of RM 8671 should provide a platform for monitoring the evolution of therapeutic protein characterization.