1,4-Naphthoquinone scaffold is well known for its chelating ability and electrochemical properties (Hillard et al., 2008; Martinelli et al., 1999). It contains two ketone groups as crucial moieties, which are responsible for many biological activities because of their abilities to accept electrons (Benites et al., 2010; O'Brien, 1991). Various biological activities of 1,4-naphthoquinone derivatives have been reported, i.e., anticancer (Kishore et al., 2014; Mallavadhani et al., 2014; Nasiri et al., 2013; Prachayasittikul et al., 2014; Sreelatha et al., 2014), radical scavenging (Kumar et al., 2013; Lebedev et al., 2008; Song et al., 2000), antimicrobial (Ryu and Kim, 1992; Sreelatha et al., 2014; Tandon et al., 2009), antiviral (Crosby et al., 2011; Da Costa et al., 2013; Ilina et al., 2002), antifungal (Castro et al., 2013; Pawar et al., 2014; Tandon et al., 2009), antitrypanocidal (Salmon-Chemin et al., 2001) and antiplatelet (Jin et al., 2004; Kuo et al., 2011; Lien et al., 2002; Yuk et al., 2000) activities. It was found that structural modification can effectively modulate the electrochemical behavior of 1,4-naphthoquinone compounds, thereby affecting their biological activities (Hillard et al., 2008). The introduction of amino and/or chloro moieties into the core structure of 1,4-naphthoquinone was documented to improve the redox potential of the compounds (Benites et al., 2010; Salunke-Gawali et al., 2014).