We also performed enrichment analyses to test if previously established marginal effects SNPs (Pm<5×10−8) are enriched for nominally significant (Pint<0.05) interactions in the SNP × physical activity or SNP × Smoking analyses, but no enrichment was observed (Table 3; Fig 1B). By contrast, for the physical activity and smoking interaction tests (using all pruned SNPs), the lower end of the Pint distribution (Pint<0.05) was enriched with SNPs that were nominally significant in the Levene’s test analysis (Pv<0.05) (Table 4). This enrichment translated into an OR of 1.08 (95% CI: 1.01, 1.14) for a SNP to have Pint<0.05 given Pv<0.05 vs. Pv≥0.05 for SNP × physical activity interaction. The corresponding OR for the SNP × smoking interaction test was not significant (OR = 1.02; 95% CI: 0.96, 1.08).