Paracrine factors connect between keratinocytes, fibroblasts, and melanocytes within the skin and play a vital role in ultraviolet (UV)-induced pigmentation and melanocyte activity. More recently, dermal fibroblasts were demonstrated to regulate cutaneous melanin production through secrevarious cytokines. In dark human skin, neuregulin (NRG)-1 is highly expressed by fibroblasts, suggesting its potential role in constitutive human skin color regulation. Human palmoplantar area is thicker and lighter in color than the nonpalmoplantar area. It has been demonstrated that fibroblasts produce abundant Dikkopf-1 (DKK-1) in the palms and soles, and then suppress the growth and function of melanocytes by arresting the Wnt-signaling pathway . In addition, fibroblasts also secrete numerous melanogenic factors, such as stem cell factor (SCF), hepatocyte growth factor (HGF), keratinocyte growth factor (KGF), corticotropin-releasing hormone (CRH), endothelin-1 (ET-1), interferon-γ (IFN-γ), and interleukin-1 (IL-1) . Several studies have suggested dermal fibroblasts play a central role in regulating melanocyte functions and influencing human skin pigmentation and constitutive color regulation.