Globally, these are interesting times to apply omics technologies in order to improve human health. Unfortunately, the African continent is way behind in terms of the financial and institutional commitment required to successfully implement a genomics program for research and clinical use. Genomics is a multi-million dollar endeavor with far reaching implications for a healthy and productive continent . It will unravel health risk, accelerate drug discoveries and motivate lifestyles [49, 50]. Of the sub-Sahara African nations, only South Africa is investing in genomics technologies despite the success stories reported in developed countries around the world. For instance, Nigeria is a country of about 200 million people and there is no genome center despite the training and collaborative opportunities presented through the Human Heredity and Health in Africa (H3Africa) Initiative (h3africa.org/) , which facilitates genomic researches and manpower development across Africa. Other factors that discourage the application of molecular research and emerging omics-based techniques to routine diagnostic oral pathology practice in Africa includes: poor access to research journals and conferences ; lack of needed skilled manpower [53, 54]; oral pathologist-to-population ratio (including workload and interest) [53, 55]; lack of well-equipped infrastructure such as laboratories and clinics [56–58]; poor internet facilities ; unstable electricity/power supply ; unfavorable health policies [61–63]; poor collaborative team science [64, 65]; knowledge gaps/educational levels [66–68]; war/local unrest ; lack of disease registries ; data/record gap in hospitals units [70, 71]; and religious/cultural beliefs , inter alia.