Nevertheless, the studies about rs7799039 and rs1137101 polymorphisms with the risk of BC at present were still controversial: the study by Liu et al.  discovered that no significant association between rs7799039 polymorphism and BC risk; while Yan et al.  found the Leptin G2548A gene polymorphism played an important role in BC susceptibility, especially among Caucasians. Similarly, results of previous publications for LEPR Q223R rs1137101 and BC risk were also inconsistent [22, 23, 24]. As some new studies published, we conducted this systemic meta-analysis to clarify the role of genetic variants among leptin and leptin receptor in the occurrence and development of BC.