Pancreatic cancer incidence and mortality have increased in recent years . Surgery is currently the most effective treatment option. However, pancreatic cancer is typically diagnosed at an advanced stage when surgical treatment may no longer be effective. Adjuvant chemotherapy is the standard of care for patients after pancreatic cancer surgery and for patients with advanced-stage disease . Gemcitabine as single-agent chemotherapy has traditionally been the standard treatment regimen, but it has a modest survival benefit . More recently, FOLFIRINOX and Nab-paclitaxel plus gemcitabine have become the standard of care [18–19]. However, poor clinical outcomes are still observed as a result of drug resistance and the side effects of chemotherapy. Therefore, new chemotherapeutic agents are required to improve patient outcomes .