As shown in Table 1 (see also Fig 1A and S1 Table), the Spearman’s ρ for the association between Pm and Pv for all pruned SNPs was of very small magnitude and only statistically significant for BMI. The exclusion of SNPs based on progressively more conservative Pm thresholds (Pm<0.05; Pm<10−4; previously established loci with Pm<5×10−8 in external datasets), saw corresponding improvements in the magnitude of these correlations, which were statistically significant for all traits except TC when focusing on previously established loci. The BMI correlation at the Pm<0.05 threshold, as well as the test of equality with ρ for all SNPs, was statistically significant, suggesting concordance between marginal and variance signals at a nominal level of significance. The odds ratio (OR) for a SNP to have both Pm<0.05 and Pv<0.05 as compared to Pv≥0.05 was 1.33 (95% CI: 1.12, 1.57) for BMI while the 95% CIs of ORs for other traits included 1. On the other hand, the P-value for a non-zero ρ for TG was statistically significant when focusing on the established loci and at Pm<10−4, suggesting concordance between marginal and variance signals at more conservative Pm thresholds.