In the next analysis step, we identified 311 genes related to PKP2 following the criteria defined in the Methods section: (i) Five genes form a complex with PKP2, (ii) 33 genes interact with PKP2, (iii) four genes are transcription factors of PKP2, (iv) 275 genes are involved in one of 12 biological processes together with PKP2, (v) and three genes are paralogs of PKP2. A list of these PKP2-related genes is available as Additional file 1: Table S2. Four Fam1 genes and ten Fam2 genes were in the set of PKP2-related genes and were prioritized based on their expression in the heart, the number and type of variants, their allele frequencies and deleteriousness prediction. These PKP2-related genes and variants of both families are summarized in Table 2. The full table with additional, detailed annotations is available as Additional file 1: Table S3.