We agree that additional Cre driver lines should be used to delineate shha functions in other tissues, however importing such Cre driver lines and analyzing adult regeneration in the homozygous mutant background could not be completed within the given period for this revision. While our data does not rule out a role for extra-epicardial shha or the redundant action of other Hh ligands, the major focus of our study is to establish a genetic method facilitating an inducible, tissue-specific gene knockout analysis in zebrafish and demonstrate its utility in embryo and adult zebrafish. Further investigation of Shha function during regeneration using different Cre driver lines is important, but it will be a focus of a future study.