Copaifera diterpenoids generally showed weak docking energies against the parasite cysteine proteases, L. donovani cathepsin B, L. major cathepsin B, or cruzain. This docking behavior of diterpenoids with Leishmania cathepsin B  and cruzain  was previously observed. Leishmania donovani and T. cruzi cyclophilins also showed weak docking energies.