Vasodilator-stimulated phosphoprotein phosphorylation flow cytometry assay is used to monitor platelet responsiveness to P2Y12 targeted antiplatelet therapy (particularly in tailoring the treatment with the oral P2Y12 inhibitor clopidogrel) (Gachet, 2012; Fitzgerald and FitzGerald, 2013; Siller-Matula et al., 2013; Danese et al., 2016).