The EtOAc extract of a Chinese collection of S. latiuscula was concentrated in vacuo and subjected to a sequence of normal, reversed phase, and gel chromatography, with HPLC-MS analysis being used to prioritize fractions of interest. Following this strategy, we isolated and characterized six citric acid derived natural products, aconitates A–F (1–6), together with two known and ten new polybrominated phenol adducts, symphyocladins C/D (7a/b), and symphyocladins H–Q (8a/b, 9a/b and 10–15), respectively (Figure 1). A spectroscopic analysis approach (see Table 1, Table 2, Table 3, Table 4 and Table 5) to the structure elucidation of all of these metabolites is summarized below.