The mPFC is associated with motivation as the center of emotion integration. A previous study posited that the activation of mPFC diminished social defeat . Deep brain stimulation in the mPFC ameliorated the symptoms of patients suffering from severe depression . The social avoidance of the intruder mice reduced the expression of IEGs in the mPFC for novel contexts and social objects at an early stage of social defeat. The social interaction of the control mice led to the high expression of IEGs in the mPFC for novel social objects. The inhibition of the BLA by Mus treatment increased the social interaction and exploration time for novel contexts, suggesting that BLA establishes and consolidates social information. Stress recovery was aided by inhibiting the function of BLA after an aversive stimulation at an early stage. Disturbances at critical times affect the efficacy of the consolidation or extinction of the aversive stimulation. Consolidation and extinction are based on synaptic plasticity and new protein synthesis, both of which are dependent on the duration of the neural activity. Therefore, the time window of a treatment is important. Salinas reported that training-related IGF-II-dependent memory enhancement is restricted to a temporal window of less than a day. However, the enhancing effect re-emerges at a later time if IGF-II is combined with memory retrieval, which reactivates the memory and induces reconsolidation. The IGF-II effect following retrieval is also temporally limited and restricted to a temporal window that overlaps with the reconsolidation-sensitive period of inhibition avoidance . For the retrieval-induced memory fragility and the IGF-II-dependent enhancement, both of them require new protein synthesis,but in different brain regions, such as the amygdala in the former and the hippocampus in the latter. Therefore, social fear memory was in a sensitive period during the first 3 days after aggression. When activated, this memory could either be significantly weakened or enhanced. These findings suggested that reconsolidation is a lingering consolidation process [44, 45].