We understand the reviewer's concern and deleted the analysis excluding the exceptional haplotype from Figure 8 and reported the R2 of the full dataset shown in Figure 8—figure supplement 1E (R2 = 0.13) as suggested. We changed the respective parts of the text, worded the related conclusions less strongly (subsection “PRO2+ and INT6+ polymorphisms contribute to global variation of FLM levels” and Discussion) and changed Figure 8 accordingly.