PCP regulation may play a role in adhesion and fusion as suggested in both zebrafish and Xenopus studies. Firstly, cell division regulated by PCP signaling leads to rescue of neural tube morphogenesis in the trilobite zebrafish mutant . Secondly, the Xenopus adhesion molecules, NF-protocadherin, and its cytosolic partner TAF1/Set have been suggested to participate in CE after the neural folds are formed. Disruptions in NF-protocadherin and TAF1 can lead to a shortened AP axis that was not evident until stages 22–25, some time after neural tube closure .