DMS has longevity benefits in Caenorhabditis elegans and Drosophila via reducing accumulated oxidative damage. (A) MDA contents in adult (20 days) and aged flies (45 days) were measured (20 flies in a sample, n = 6 independent samples, Student's t‐test, **P < 0.01). (B) Lifespan analyses of wild‐type flies exposed to DMS (10, 100 or 1000 μm). n = 200, log‐rank post hoc Kaplan–Meier survival analysis, P < 0.01 vs. control. (C) DMS reduced the levels of superoxide. Representative images of aged and adult worms labeled with the MitoSOX red. The scale bar represented 100 μm. (D) Quantification of superoxide levels by MitoSOX labeling (n = 6, Student's t‐test, ## P < 0.01 vs. adult, **P < 0.01 vs. aged worms). (E) Lifespan analyses of wild‐type nematodes exposed to DMS (1, 5, or 10 μm). n = 70, log‐rank post hoc Kaplan–Meier survival analysis, P < 0.01 vs. control. (F) MDA contents in adult (5 days) and aged worms (20 days) were measured (20 worms in a sample, n = 6 independent samples, Student's t‐test, # P < 0.05 vs. adult control, *P < 0.05 vs. aged control).