Despite results by Balvedi, et al.5 (2010), who stated PUI was more effective in terms of CH removal than syringe irrigation in the coronal and middle third regions, no statistically significant difference was found between the two irrigation regimes in the apical third. In the aforementioned study, researchers mixed CH with different liquids and preferred saline solution to the irrigant. In this study, CH was mixed with only distilled water and 2.5% NaOCl was used as the irrigation solution. The reason for the differences between the studies may be the various solutions and CH vehicle used. Similar to our findings, a recent systematic review showed the superiority of PUI over syringe irrigation on the removal of CH from the apical part of root canals10.