Conversely, it has been shown that MO extracts have anti-inflammatory properties (Bounihi et al., 2013; Müzell et al., 2013). Its anti-inflammatory effects are due to rosmarinic acid, flavonoids, and terpenoids present in the extract. Probably, flavonoids have a more effective role by facilitating the synthesis of prostaglandin. MO administration can suppress the pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α (Bounihi et al., 2013).