All R code used to generate the figures and statistics of the paper is included in Supplementary Data 5. Source code for the ensemble somatic mutation caller, SMuRF68, can be found at https://github.com/skandlab/SMuRF. Source code for estimating background mutation rate from genomic covariates and identification of non-coding mutation hotspots is available at: https://github.com/skandlab/MutSpot.