In the last 10 years, ageing research using animals has gained an increasing attention with the availability of drug-induced animal models which can be used to study accelerated ageing. D-galactose-injected rodent models recapitulate many features of brain ageing and have been extensively applied to study the mechanisms of brain ageing [3, 7, 8]. Following administration, d-galactose reacts with … to form advanced glycation end-products (AGEs) and cause oxidative stress. This in turn can lead to increased malondialdehyde (MDA) levels and decreased superoxide dismutase (SOD) and glutathione peroxidase (GSH-px) activities [9–11]. Its administration in rodents also has been reported to cause neurobehavioral changes including cognition and motor impairment; reduced neurogenesis; neurodegeneration; and caspase-dependent apoptosis and mitochondrial dysfunction .