Genotyping of recruited subjects for the SOD2 A16V polymorphism showed that the two alleles had the same frequencies in water polo players (A 0.50 versus V 0.50). The heterozygous AV16 genotype was the most represented among athletes, being found in 57.2% (n = 16) of the study cohort, while AA wild-type (21.4%; n = 6) and VV homozygous mutated subjects (21.4%; n = 6) had the same distribution.