One promising approach is the incorporation of ncAAs, since, apart from the 20 standard proteinogenic L-amino acids, they offer new chemical features to AMPs, e.g., by introducing fluorinated or photocaged residues (McKay and Finn, 2014; Zambaldo et al., 2017). Moreover, this approach provides a whole toolkit of new chemical modifications for AMPs, which even allows to combine peptides by diverse “click chemistry” approaches, e.g., the Staudinger ligation (Wang et al., 2015) or strain-promoted azide-alkyne cycloaddition (SPAAC) (Budisa, 2013; Kim et al., 2016).