A 35-year-old African American man with a past medical history of sickle cell disease presented to our hospital by transfer from an outside hospital. Clinicians at the outside hospital originally saw him when he had a 2-day history of fever with a maximum temperature of 103 °F. The patient also complained of worsening headache, neck pain, and shortness of breath. He was admitted for suspicion of sepsis. During the evaluation process, the clinical condition of the patient worsened with increasing shortness of breath, intensifying headaches, and increasing neck pain. The patient received a lumbar puncture, the results of which were indicative of meningitis. The patient underwent magnetic resonance imaging, which revealed a possible Arnold-Chiari type I malformation and a cervical cord syrinx with associated myelitis. The patient was transferred to our hospital, and, upon arrival, he was paralyzed from approximately the level of C4 to the feet.