Although therapies exist to manage GDM (4–7), affected pregnancies are associated with considerable maternal and fetal morbidity, being at particular risk for preeclampsia (PE). PE is a severe hypertensive disorder of the latter part of pregnancy (8–10) characterized by wide-spread endothelial dysfunction mediated largely by deregulation of placentally produced angiogenic factors (11). PE also involves a pronounced inflammatory component, largely evident by excessive neutrophil activation (12, 13). Neutrophils, also termed polymorphonuclear neutrophil granulocytes (PMN), are currently experiencing a renaissance of scientific interest in a diverse array of human pathologies, largely due to their ability to form neutrophil extracellular traps (NETs) (14–16).