Through analysis of multi-parametric MR imaging, we have identified tumor sub-regions with unique combinations of gray-level intensities from each of the four MR modalities included in this study. From these 16 habitats, relevant (i.e. important and significant) habitats were identified based on association with OS status, and further, correlated with morphological and pathological characteristics of tumor, such as leading edge, infiltrating tumor into normal brain, edema, and enhancement around lesion edge. For example, habitat 10 was associated with canonical tumor sub-volumes like edema, peripheral tumor tissue, and enhancement around lesion edge.