Following an injection of 10 ml of D-mannitol (25%; i.v.), separate craniotomies were performed over the left ventral posterior suprasylvian region (Horsley-Clarke or HC coordinates: P3–P8 mm, lateral 15–20 mm) and left area 19 (HC coordinates: A2–P8 mm, lateral 2–12 mm). Between cooling sessions, silver foot temperature was maintained at 36°C.