(A) Schematic representation of the mir-17~92 cluster and its paralogs mir-106b~25 and mir-106a~363. Constituent miRNAs are color-coded according to their seed families. (B–E) Quantitative RT-PCR measurement of mature miRNA expression across eighteen cell lines derived from primary KPC and 17KPC tumors. Some miRNAs share sufficient sequence similarity that standard oligonucleotides amplify both species equally (e.g. miR-19a and miR-19b), and therefore not all miRNAs are individually plotted. p values: **** < 0.0001. Error bars represent standard deviation from the mean.