In the Partners Demonstration Project, the use of a validated HIV-1 risk score identified heterosexual HIV-1 serodiscordant couples with characteristics consistent with high-risk of HIV-1 transmission. The score is comprised of easy to measure behavioral and biologic risk factors for HIV-1 [10, 12] and those with high scores are a natural priority population for coordinated delivery of early ART and time-limited PrEP prior to ART initiation and viral suppression. Three-quarters of the couples with a high score (≥5) were motivated to join the study and initiate PrEP and/or ART for HIV-1 prevention.