The ROS-induced adaptive response following regular long-term training leads the upregulation of the antioxidant enzymatic systems, including superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) that act synergistically with nonenzymatic antioxidants, that is, vitamins C and E, reduced glutathione, thiols, lipoic acid, and metallothioneins, to buffer the negative effects of oxidative stress [2, 11]. However, evidence has been provided by several investigations that exercise may positively or negatively affect oxidative status on the basis of training load, training specificity, and the basal level of training. In particular, the degree of oxidative damage and the time course for elevation in oxidative stress markers, during and following both acute aerobic and anaerobic exercise, resulted to be dependent on the type, intensity, volume, and duration of muscle contraction, leading to differences in the oxidative status between athletes in different sport disciplines [6, 8, 11–14].