JBCdS, JCSA, ELdA, and LMdOP performed experiments, reviewed data, and planned the experimental strategy. MG collected data using a FACS ARIA BD flow cytometer. ABdP, JBCdS, TMAdSEP, LBdS, PCGN, and MdRQL performed all diagnostic tests. RVdC, JBCdS, TMAdS, LBdS, and ELdA collected samples and provided clinical information. JBCdS, JCSA, and LMdOP conceived and directed the study, and wrote the manuscript. All authors have critically read and edited the manuscript.