As our observations have demonstrated, the ROM for the AUS/FLUS BSRTC category is closer to the ROM of the sFN category in patients younger than 55 years. From a clinical perspective, these observations suggest that it may be appropriate for patients younger than 55 years of age with an AUS/FLUS diagnosis to be offered a diagnostic thyroid lobectomy, as opposed to observation or to a repeat FNAB, as recommended by the BSRTC. Irrespective of potential developments in this field, we believe that further study of the relationship between patient age, gender, and ROM within the BSRTC indeterminate diagnostic groups is warranted, and ultimately may lead to improved cancer risk estimation, and thus, better tailoring of treatment for individuals diagnosed with thyroid nodules.