ROC analysis was used to determine whether serum markers are powerful to predict HCC in the cirrhotic population. The results showed that AFP, AFP-L3, and ALT had relatively good predictive power for HCC progression; AUC were 0.736, 0.744, and 0.693, respectively (see Table 4, Figure 2). The multiple regression analysis suggested that the combination of three markers could not significantly improve the predictive efficacy; the best combination was ALT and AFP, which obtained AUC of 0.780; see Table 4, Figure 3.