Recently, three studies directly focused on the neural associations of the tendency to the IA. Wen and Hsieh (14) explored the relationship between the whole brain functional connections and the level of IA in a group of young adults (19–29 years) and found two networks mainly consisted of frontal regions were correlated to the tendency of IA. Li et al. (15) reported that the structure and functional connectivity of the right dorsolateral prefrontal cortex were positively correlated with the IAT score in a group of healthy young adults (18–27 years). A study by Kühn (16) revealed that the GMV of the brain regions within fronto-striatal network correlated to excessive Internet use assessed by IAT score. Additionally, previous studies have also demonstrated that the GMV changes were related to the online game addiction severity in the IGD subjects. For example, a study by Weng et al. demonstrated that the GMVs of the right orbitofrontal cortex and bilateral insula were positively correlated with the online game addiction severity in the IGD subjects (7). Cai et al. reported increased GMV of nucleus accumbens was associated with the IAT score in the IGD individuals (17). A study by Zhou et al. showed that lower GMV in the right orbitofrontal cortex was related to higher online video gaming addiction severity within the Internet gamers (18). These studies demonstrated that brain structures and functions were associated with the level of IA. However, the relationship between the tendency to IGD and the GMV across whole brain was not yet clearly evaluated in adolescents (14–18 years). The adolescent between 14 and 18 years of age is in a critical period of psychological development and is prone to addiction and adverse effects (19, 20). Many studies regarding the substance addiction paid close attention to adolescents aged from 14 to 18 years (21, 22). A large-sample study demonstrated that the IGD is very common in Chinese elementary and middle school students with a incidence of 22.5% among those students who play online games (2). Therefore, it is more necessary to investigate the brain structural correlations with the tendency to IGD in adolescents (14–18 years).