Analysis of NK cells (Fig. 2) stressed the importance of long-term follow-up of representation of this population. The decrease of NK cells below 10.8% of the total count of lymphocytes increased the probability of CDP. Overall, a decreasing trend in the percentage of this population in peripheral blood was present, but transient more significant increase (of more than 28.7%) increased the probability of EDSS worsening in the first and third year of follow-up.Fig. 21) ROC curves of CD3-CD16 + 56+ NK cells to predict CDP at one year. AUC for the population relative value = 0.672, AUC for the population relative value change compared to baseline = 0.507, AUC for the population relative value change compared to a measurement one year before = 0.541. 2) Survival curves and asymptotic log-rank tests for groups divided by the threshold