Thus, the results of the docking studies carried out on HER2 corroborate to the findings that the most suitable drug like properties are possessed by Stigmasterol. In comparison with Oleic acid it is a better bet as oleic acid is more lipophilic commonly present in sponges, which is relatively less druggable. This provides evidence of how a marine sponge can be a source of potential anti- cancer agent. Further in-vivo studies need to be performed in future to validate the wet lab results. The preclinical studies will pave way for a potential anti-cancer compound.