NTDs have a profound impact on society. The morbidity and mortality rates of spina bifida patients decrease with improving medical care. Taking the United Kingdom as an example, Bowman et al.  in their 25-year follow-up of 71 spina bifida aperta patients found that at least 75% of these children can be expected to reach their early adult years . Moreover, as many as 85% are attending or have graduated from high school and/or college. More than 80% of young adults with spina bifida have social bladder continence. In the same study, 49% had scoliosis, with 43% eventually requiring a spinal fusion. Approximately one-third of patients were allergic to latex, with six patients having experienced a life-threatening reaction. Renal failure was 6.8–9.0 times more common for males and 9.2–11.5 times more common for female patients compared with the general population in each of the years 1994–1997 in the UK . Therefore, longer life equates with the need for progressively better quality of life.