We also performed similar TEG experiments with PPP (table 1). After 10 min exposure, just the initial clotting time R was changed. The results were not specific for O111:B4 LPS as O26:B6 LPS added to PPP behaved similarly. The decreased R time is indicative of reaction time, and therefore the time to first measurable clot formation is also significantly decreased (as the initiation of the clot starts faster with than without LPS), confirming a hypercoagulable state with added LPS. After 30 s exposure time, both the R and the TMRTG were shorter (in the five patients tested). This confirms our hypothesis that LPS causes (near) instant hypercoagulability. Here also, the results were not specific for O111:B4 LPS as O26:B6 LPS added to PPP also showed a decreased R-time. TTG of PPP was increased (but not significantly increased) after 30 s, as well as 10 min, which compared with results of PPP from patients with Alzheimer's type dementia .