Spatio-temporal evolution of BPRs in the dendrites. The figure extends the description of the simulations shown in Figures 6, 7. For simplicity, only the currents showing the largest changes are shown (Cav3.3, Cav2.1, KCa 2.2) along with [Ca2+]i. Note the log scale (all parameters are made positive) to account for large variations on the ordinate. (A) Spatial profile of ionic currents and [Ca2+]i changes. Note the larger extension of dendritic activation when stimuli are delivered to sector II than I. Synaptic stimuli are given either in sector I and II. The color scale shows relative values for Vm (−80; 40 mV), [Ca2+]i (4.5*10−8; 3*10−7 M/l), ICav3.3 (−1*10−9; 0 mA/cm2), ICav2.1 (−0.001; 0 mA/cm2), IKCav2.2 (0; 1*10−5 mA/cm2). (B) Temporal profile of ionic currents and [Ca2+]i changes taken from five different compartments indicated by colors (see the legend on top). Although the synaptic stimulus is given only in sector I or II, there is a progressive invasion of neighboring dendritic regions that can lead to full-blown Ca spikes and large ionic current activation outside the stimulated sector (e.g., arrows). These dynamic changes are more marked when stimuli are delivered to sector II than I.