In order to determine the response time of the adherence monitor to temperature change, the thermistor voltage, Vth was measured as a function of ambient temperature as the device was cycled alternately between chambers held at 28°C and 37°C. Values of Vth were converted to temperature using a second-order polynomial fit to a five point temperature calibration curve over the range 25°C -44°C. The device response time was calculated as the time required to heat from 10% to 90% of the full-scale temperature difference (28.9°C to 36.1°C) or to cool from 90% to 10%.