The presence of extrapancreatic inflammation was reported to be an essential determining factor of AP severity in a previous study. More investigations found EPIC had a high accuracy for the early prediction of organ failure in patients with AP. Furthermore, EPIC scores can predict pancreatic pseudocysts in the early phase of severe AP. Conversely, distinct from our findings, Mortele and colleagues did not find a significant correlation between the prevalence of renal/perirenal involvement in complications and severity of pancreatitis.