The clinicopathological characteristics of patients are summarized in Table 1. The male-to-female ratio was 7:1, and the median age was 66 (range, 42–92) years. Forty-five percent of patients were in their seventh decade. The most common primary tumor site was the hypopharynx (38%), followed by the oropharynx (31%), larynx (18%), and oral cavity (13%). The clinical stage of these tumors was III (32%), IVA (60%), and IVB (8%). Chemoradiation therapy (CRT) was performed in 75% of patients. The median value and range of AST levels, ALT levels, and the AST/ALT ratio were 22 (5–143) U/L, 15 (4–184) U/L, and 1.42 (0.42–4.30), respectively. The number of patients with AST levels above the normal range (AST > 32 U/L) and those with ALT levels above the normal range (ALT > 37 U/L) were 64 (18%) and 36 (10%), respectively. The median follow-up period for the surviving patients was observed to be 57.2 months (range, 24.6–125.3).