Supaglutide improves glucose tolerance and insulin sensitivity in the DIO mice. Glucose concentrations during (A) IPGTT or (B) an insulin tolerance test (ITT) in control and supaglutide-treated mice. The significant differences between groups in (A) and (B) are analyzed using two-way RM ANOVA method. Area under curve (AUC) for (A') IPGTT and (B') ITT were calculated. The significant differences between groups in (A') and (B') are analyzed using unpaired Student's t-test. All values are means ± SE (n = 5 for each group). *p < 0.05; **p < 0.01.