This suggests that CBT has the potential to work effectively in the context of a gamified mobile app for smoking cessation; however, future research involving wider distributed samples and longer periods is required to draw more generalizable conclusions. The findings also suggest that a mobile app must be well developed, preferably with an underlying behavioral change mechanism, to promote positive perceptual and health behavior change in the context of smoking cessation. The potential of digital CBT delivered through a gamified mobile platform should be seen as a powerful tool to overcome current health care challenges.