Decision-makers receive gain/loss information after each round of card selection in IGT-related experiments. It is impossible to guess the internal gambling structure in advance, or to predict how to make the most money, but once the game is in progress, decision-makers gradually tend to prefer the good decks and avoid choosing the bad decks, potentially drawing upon physiological feedback. For example, their SCRs could be construed as an alarm signal that encourages the decision-maker to avoid selecting the bad decks before the cards are overturned. At the start of the game, participants are unable to differentiate between good or bad decks, but they exercise a “gut-feeling” in making selections for the IGT. This emotion thus influences decision-makers by guiding them to eventually choose only the good decks and thus obtain the best outcomes. Conversely, participants affected by VMPFC lesions are devoid of the SM system and are therefore unable to register gain/loss experience during the IGT. Therefore, VMPFC patients were unable to inhibit their preference for the bad decks, lost consecutively, and presented a shortsighted choice pattern (Bechara et al., 1997, 1999, 2000).