Adhesion of the tips of the apposing neural folds is the final step in primary neurulation, enabling the neural tube to complete its closure . The tips of the apposing neural folds and the eventual point of adhesion are reported to contain cell to cell recognition molecules (as demonstrated in red in Figure 3(c)) which may be required for the specific adhesion process to occur [233–243]. This is supported by previous evidence that the cell surface of the neuroepithelium is lined by carbohydrate-rich material that is not observed in the rest of the neuroepithelium . Removal of GPI-anchored proteins from the cell surface during neurulation results in delayed spinal neural tube closure . Interestingly, work performed by Abdul-Aziz et al. and Pyrgaki et al. demonstrated protrusions emanating from the neural fold tips that interdigitate leading to eventual adhesion [244, 245] (Figure 3(d)). Ultimately, the newly formed neural tube undergoes remodelling via apoptosis to enable the neural tube to separate from its surface ectoderm [228, 246] (Figure 3(e)).