The ability of spatial learning and memory of the mice was evaluated through the Morris Water Maze (MWM) test (Edwards et al., 2014; Milner et al., 2014). The test was performed on the 14th day after drug administration. The pool of MWM was 120 cm in diameter, filled with water (22–25 °C) and divided into four quadrants. A hidden platform was placed in the center of the target quadrant 1.5–2.0 cm under the surface of the water. MWM included the place navigation test and the spatial probe test. In the place navigation test, all mice were trained three times per day for four days. Mice were initially placed in the three quadrants which did not have a platform. Each trail lasted for 60 s or ended as soon as the mouse climbed on the platform. The time was recorded as the escape latency, if the mouse climbed on the platform within 60 s. If the mouse failed to find the platform within 60 s, its escape latency was recorded as 60 s. The spatial probe test was performed following the end of the place navigation test. In this test, the platform was removed, and each mouse was allowed to swim for 60 s. The searching distance in the target area and total area were measured. Data was recorded and analyzed by Top View Animal Behavior Analyzing System (Version 3.00).