The risk factors analysis showed that incidence rate of HCC in patients with high AFP, AFP-L3, ALT, and AFP-L3/AFP levels were extremely significantly higher than that those with normal levels (RR = 2.99, p = 0.000; RR = 2.92, p = 0.000; RR = 2.72, p = 0.001; RR = 2.34, p = 0.003). Our results revealed that cirrhotic patient with higher levels of AFP, AFP-L3, AFP-L3/AFP ratio, or ALT had a risk of developing HCC and these four markers were risk factors for HCC. In contrast to the previous studies, we find that high GP73 level seemed to be a protective factor for HCC, because elevated GP73 levels were associated with a lower risk of incident HCC (see Table 3).