RM 8671 has demonstrated stability and homogeneity with respect to the specified physicochemical properties using the qualified methods described herein, and is consequently suitable as a Reference Material. Significant effort was made to ensure lot-to-lot homogeneity and stringent method optimization to produce measurements with minimal sample preparation artifacts. Ultimately the values, from a metrological perspective, are method-specific and intended as a baseline for comparison of results from orthogonal, yet related assays that may be performed in a given user’s laboratory. This measurement approach, however, is indeed fit-for-purpose as the measurement technologies selected are representative of the current state-of-the-art in biopharmaceutical characterization. The availability of a Reference Material along with the well-defined analysis parameters reported throughout this publication series provides for the first time a foundation upon which longitudinal advances in biopharmaceutical characterization can be benchmarked. Future measurement technologies, regardless of their mechanistic principles, can be traced back to a consistent quality material of the same constituent product quality attributes.