An effective cure strategy will need to target both the latent and active viral reservoir. Thus far, strategies to eliminate the viral reservoir have focused on early initiation of antiretroviral therapy (ART) , increasing the administered amount of current antiretroviral drugs  or manipulation of cellular and viral transcription factors that eliminate transcriptional or post-transcriptional blocks [19–23]. Curative strategies focused on the activation of dormant virus that would lead to its destruction via host immune or viral cytopathic effects have not led to a reduction in the number of infected cells, however [8,24–29].