Sbp1 has a domain organization with an N-terminal RNA recognition motif (RRM) domain, a central arginine–glycine –glycine (RGG) domain and a second C-terminal RRM domain (Fig. 1A). Because of the diverse roles that RRM and RGG domains play in mediating RNA–protein, protein–protein, and less frequent but important, RNA–RNA interactions (Cuchalová et al. 2010; Rajyaguru and Parker 2012; Daubner et al. 2013; Thandapani et al. 2013), Sbp1 has the potential to target different mRNAs and regulate their translation in a transcript-specific way. Furthermore, unlike the majority of RGG-motif containing proteins which have their RGG repeats in either N or C terminus (data not shown), the location of RGG repeats between the two RRMs suggests potential function of structural modulation of the RNA target by this protein. Despite the importance, very little is known about molecular mechanisms by which Sbp1 regulates transcript-specific mRNA translation.