Ca channel activation and the consequent Ca entry into the dendrites may activate KCa currents overtaking inward currents and generating a protracted repolarizing drive. Actually, the current transmitted from the dendrite to soma (Idend-soma) and from soma to AIS (Isoma-AIS) was reduced during the pause compared to pacemaking regime. Therefore, reduced depolarizing current transmission from the somato-dendritic compartment to AIS appears as the main responsible of the pause.