The majority of the reviewed guidelines—such as by Hurkmans et al. (2012), Moss et al. (2012), Watanabe et al. (2012), Qaseem et al. (2013), Min et al. (2015), Young et al. (2015), and (National Institute for Health and Care Excellence, 2011)—highlighted that physicians must take into account the risk profile of therapeutic options (e.g., possible complications, adverse events and serious side-effects) and must inform the patient about all associated risks. However, detailed guidance for side-effect management was not usually provided. Half of the reviewed guidelines—including those by Hurkmans et al. (2012), Watanabe et al. (2012), Qaseem et al. (2013), Thompson et al. (2013), Partridge et al. (2014), Stratigos et al. (2015) and other publications—provided recommendations related to comorbidities. This aspect was addressed mainly from the perspective of how comorbidities influence treatment pathways or how they change the efficacy and benefit of primary therapies. Potential interactions between primary treatment and therapeutic management of comorbidities were also mentioned. Treatment-free remission and extended life were mentioned as patient values roughly in 50% of the cases (n = 9 and n = 10 respectively).