Analysis of CBS mutations in different gastric cancer subtypes. a–d Mutation count per tumor around CBSs in the four gastric cancer subtypes. e Elevated mutation rates at CBSs compared to flanking regions. f Somatic substitution patterns within CTCF motifs for hotspot mutations and all mutations, respectively. g The negative log P-values of mutation recurrence of all CBSs evaluated with a CBS-specific background model. CBS hotspots identified in Fig. 3a are highlighted in magenta. The horizontal line marks the Bonferroni adjusted P-value of 0.01