Since overt neutrophil activity (56) and excessive NET formation in the placental intervillous space are evident in PE (20), our new data describing analogous findings in cases with GDM may aid in explaining the increased of risk of these pregnant women to develop PE (8–10). Furthermore, since a large proportion of the circulating neutrophil pool in GDM exhibit an excessive pro-NETotic capacity, ready to form NETs rapidly at a moments notice, this could explain why the pathological transformation to PE occurs so abruptly and is so difficult to detect in advance (9, 10).