Association between CBS mutations and genomic instability. a Distance to the nearest CNV breakpoint from CBS hotspots and other non-CBS mutation hotspots. b Distance to the nearest CNV breakpoint from CBSs at loop boundary and non-boundary CBSs. Wilcoxon rank-sum test P-values are shown. c Correlation of mutation rates with SCNA breakpoint density. d Correlation of normalized mutation rates with SCNA breakpoint density, correcting for the background mutation rate in each bin. Error bars represent the s.e.m. e The violin plots show the VAF distributions of somatic mutations in diploid regions of individual tumors. VAFs of the mutations at CBS hotspots are marked by red vertical lines. f Comparison between VAFs of the CBS hotspot mutations and VAFs of non-silent coding mutation on GC driver genes. The red points represent the median VAFs in each group. The dashed lines match mutations from the same samples. P-value is calculated by paired Wilcoxon rank-sum test