Studies were conducted in female mice overexpressing rabbit calpastatin (CalpTG) and control mice (WT) on a C57/bl6 background, bred and housed in similar conditions in a pathogen free zone. These mice were created and characterized in our laboratory. All procedures involving mice were conducted in accordance with national guidelines, institutional policies, local ethical committee and Research Ministry. The experimental protocol was approved by the Charles Darwin Ethical committee and validated by the French research Ministry (Authorization number: Ce5/2012/00686.01).