It is of directive significance to understand the effect of prognostic factors on the prediction, diagnosis, and treatment of diseases. According to the study, PARP1 may be an independent prognostic factor of multiple malignant tumors. And PARP1 Val762Ala polymorphism may be an independent prognostic factor for cervical cancer, which might play a role in the prediction of clinical results . Collectively, the expression of PARP1 might be considered as an independent prognostic factor for the patients of breast cancer . While in the limited stage of SCLC, the expression of PARP1 was related to the progression free survival of tumor cells . The COX regression analysis conducted by KJ Xie, et al.  indicated that PARP1 was an independent adverse prognostic factor of NSCLC patients. According to Kaplan-meier survival curve, the higher expression of PARP1, the lower survival rate of patients, which preliminary suggested that PARP1 might be an independent adverse prognostic factor of NSCLC. Consistently with the above result we found that PARP1 presented high expression in NSCLC, and the survival rate of patients was decreased accompanied by increased PARP1 expression. In summary, based on gene interaction network, the shortest paths method was adopted in NSCLC gene network to find a number of candidate oncogenes of NSCLC. We conducted the functional verification on PARP1, which provided convenience for the following discussion and study of the mechanisms related to the occurrence and development of NSCLC. We found the role of PARP1 in the migration and prognosis of NSCLC, laying foundations for the following clinical experiments, and providing theoretical basis for revealing the effects of PARP1 on NSCLC.