Three reports previously studied this particular topic , but probably the resting time (2–10 s) between repetitions, or groups of repetitions in the short sets, was not enough to maintain the phosphocreatine muscle content , thus failing to avoid the involvement of the glycolytic metabolism when comparing it with continuous sets. In our study, we aimed to compare the pressure response of an IRD, with enough resting time of a CD. Additionally, we aimed to understand the progression of the systolic blood pressure (SBP) in a CD to estimate the effect of accumulated repetitions on the increasing rate of SBP throughout the set. Our inference is that the IRD would have a lower pressure response in comparison with the CD, as a consequence of a lower glycolytic involvement, despite the lack of the v-shape pressure response advantage. Additionally, we also hypothesized that the increase of SBP throughout a set can be estimated based on the accumulated number of repetitions.