The NISTmAb RM 8671 is intended to be a widely available metric used to evaluate current capabilities and compare emerging technologies to define analytical and biophysical capabilities. Each individual lot of RM 8671, shown herein to demonstrate minimal variation in product quality attributes, is accompanied by a lot-specific Report of Investigation that describes the properties of the RM and its intended use. The current publication series is a thorough expansion on the RM 8671 Report of Investigation, and affords an opportunity to report more detailed procedures and results obtained from the value assignment exercise. This comprehensive report is a necessity to demonstrate RM quality, fully describe current state-of-the-art measurement capabilities, and serves as a means to continually evaluate best practices, promote innovative approaches, and inform regulatory paradigms as technology advances.