Catalytic micelles were also prepared by O’Reilly et al. when a novel amphiphilic Sulfur–Carbon–Sulfur (SCS) pincer Pd catalyst together with a PAA (poly(acrylic acid)) based polymer self-assembled in water . The catalytic activity of the nanostructures was compared to the results achieved with the small molecule analogues of the pincer Pd complex, in a Suzuki–Miyaura coupling. When the reaction of vinyl epoxide with phenylboronic acid was realized with 2% of pincer catalyst, the rate was 100 times higher for the water-based micellar system compared to the same reaction in organic solvent with the unsupported Pd-complex. A 100 times lower amount of catalyst was also loaded (0.02%), and still the reaction rate achieved was higher than the ones in organic media. This remarkable kinetic effect was attributed to two factors: 1) the small particle radius which increased the nanoreactor’s surface area, and 2) the creation of a more hydrophobic local pocket, as the catalyst was facing directly the hydrophobic membrane. Furthermore, the nanosystem also facilitated catalyst recycling by normal extraction.