ANOVA tests were used (one-way and two-way) with confirmatory testing: Tukey (multicomparative) for quantitative data and the Chi-square test for qualitative data, both with two-tailed hypothesis. Where the two-way analysis of variance test was used for continuous temporal variables and the one-way test was used for transverse continuous variables. Furthermore, the Tukey test was used for quantitative data (continuous variables) because there was more than one group with different drugs, whereas the χ2 test was used for qualitative data (nominal categorical variables).