Sterols are the normal substrates for sterol 14α-demethylase (CYP51), and triterpenoids are expected to also target this protein as inhibitors . Nevertheless, Copaifera diterpenoids showed docking energies that may compete with normal sterols for these protein targets. L. infantum CYP51 had an average docking energy with the diterpenoids of −90.2 kJ/mol, which was generally not as good as a normal sterol substrate (obtusifoliol, Edock = −104.4 kJ/mol), but comparable to the known LinfCYP51 inhibitor fluconazole (Edock = −87.5 kJ/mol). Likewise, T. cruzi CYP51 had an average diterpenoid docking energy of −89.5 kJ/mol, but substrate (obtusifoliol) docking of −105.6 kJ/mol, and fluconazole docking energy of −90.9 kJ/mol.