Another unusual feature of this case beyond the antithrombotic therapy is ischemic colitis. Unlike mucosal bleeding, such as epistaxis or hemoptysis, ischemic colitis is ascribed to tissue hypoperfusion through the reduced blood supply to the mesenteric artery rather than bleeding tendency or a coagulation disorder. In this patient, tissue hypoperfusion may occur due to transient blood flow reduction, suggesting old age, abdominal aortic calcification, and a sudden drop in the hemoglobin level. Thus, it is unclear whether the ischemic colitis seen here was related to F5D. Furthermore, additional evidence is needed regarding whether antithrombotic therapy presents a risk factor for F5D patients developing ischemic colitis.