11) This article aims to provide a novel construct for using Cre-mediated recombination to conditionally ablate genes in zebrafish. Overall, the ability to efficiently introduce targeted mutations would be an important advance for functional work in zebrafish. The utility of this strategy seems contingent on the efficiency of homologous recombination. The manuscript would benefit by including an additional description of how the efficiency of their strategy compares with other published approaches. Is this really any better than what is out there?