The physical measurements include waist circumference, height, weight, pulse and systolic and diastolic blood pressure. Patients visit a (hospital) laboratory that collects a blood sample, if possible in fasting state, for levels of lipids (total cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides [all in mmol/L]) and glucose metabolism (glucose [mmol/L], HbA1c [%]). Measurements are taken following standard ROM protocols. Waist circumference (in cm) is measured in duplicate using a flexible nonstretching tape halfway between the iliac crest and lowest rib in standing position at the end of an expiration. Body weight is measured by calibrated scales (Seca, model 813) in light clothing without shoes or jackets. Measurements for height (in cm) will be available from multiple measurements of ROM nurses. The highest height will be used unless patients wear shoes, then the highest height without shoes is used. Pulse and systolic and diastolic blood pressure are measured after 5 min’ rest in sitting position, using a blood pressure monitor (BOSO medicus control).