It is, however, notable that a recent longitudinal study in the same cohort showed no differences in linear metabolite change between HEU and controls between 5 and 10 years, using a smaller sample of 9-year-old children scanned on a different scanner a few months earlier (Holmes et al., 2017). A limitation of the current study is that data were acquired on different scanners at each age, which does not allow straightforward examination of change in metabolites with age. The cross-sectional analyses presented here suggest that the neurometabolite increase with age may not be linear in one or both of these groups, with a difference manifesting only at the later end of this age range in the basal ganglia.