Other components of blood can be used for detection of some therapeutic targets for patients with lung cancer, including free plasma RNA or RNA in a complex with proteins in exosome or in association with platelets. Among these RNA, microRNA are of particular interest. Microparticles in plasma are heterogeneous components associated with exosomes, nucleosomes and particles of larger size. However, currently, none of these elements are used in a routine manner for detection of genomic alterations in lung cancer patients.