Congeneric nature of the dataset is basis prerequisite for any QSAR analysis. Fragment based QSAR is recent methodology were complex structures can be analyzed. 30 different G-QSAR models were generated and best one of them are selected on basis of the statistical values like r2, q2, pred_r2, F-test and standard error. The predicted activity data via QSAR models was in accordance with the observed biological activity with small variations which were clearly identified in the correlation plot of different model (Table 2 and Fig. 2). Selected model is given by.Fig. 2Figure Showing Correlation Plot for Selected GQSAR model having r2 0.88.Fig. 2Table 2Table showing observed and predicted activity of selected GQSAR model.Table 2Molecule. NoObserved Activity pMIC(μg/ml)Predicted Activity pMIC(μg/ml)Molecule NoObserved Activity pMIC(μg/ml)Predicted Activity pMIC(μg/ml)12.12.7140.91.220.90.7150.80.831.21.2160.80.74 #2.31.217#0.71.35#1.20.918#1.10.761.31.6190.61.373.34.1200.60.882.83.621#0.60.795.64.022#0.61.1101.53.7230.70.711#1.00.7240.71.1121.41.225#0.70.8130.80.7# Test Set Molecules