In subgroup analysis of LTG-induced CADR, a significant association between LTG-induced MPE and HLA-B∗15:02 was found when compared with the tolerant controls and general population (OR = 7.33, 95% CI = 1.63–33.02, P-value = 0.005 and OR = 5.44, 95% CI = 1.56–19.03, P-value = 0.003, respectively). Interestingly, a significant association between LTG-induced MPE and HLA-B∗44:03 was found when compared with both control groups (OR = 10.29, 95% CI = 1.45–72.81, P-value = 0.029 and OR = 4.73, 95% CI = 1.20–18.62, P-value = 0.046, respectively), whereas HLA-B∗35:08 was significantly associated only with the general population (OR = 109.44, 95% CI = 6.34–1889.11, P-value = 0.020) (Table 4); nevertheless, no significant associations were found in LTG-induced SCAR.