The first group contains 32 residues, the second groups have 28 residues and the third groups have 12 residues in common among the ligands in the groups. The Venn diagram shows 9 residues as common among all the groups / ligands and 23 residues as common among any two of the three groups. The isolated compounds contain almost all of their interacting residues with HER2. The following 9 residues are common among all the ligands: Thr5, Asp8, Asn37, Gln84, Leu291, Val292, Arg412, Ile413 and Gly417.