This was a prospective, consecutive, investigator-masked, nonrandomized, cohort study and was performed at a single center (Fig. 3). Twenty healthy subjects and 129 patients were enrolled in this study. There were76 men and 73 women. The mean age of the participants was 55.44 ± 13.46 years (range, 24–78 years), and the best-corrected visual acuity was 20/20 to hand motions. Eligibility criteria were: 1) normal healthy subjects and 2) patients with APACG, PACS, CPACG, POAG and CSC. Exclusion criteria were: 1) Significant corneal or media opacity; 2) Diabetes; 3) Uncontrolled hypertension (systolic > 150 mmHg and diastolic > 90 mmHg); 4) Amblyopia; 5) Neurologic or systemic disease that could compromise vision; 6) medications that are known to affect retinal structure; 7) Physical and/or mental impairment; or 8) Inability to sign a consent form. None of them had history of high myopia, ocular trauma, or ocular surgery.Figure 3Summary and flow diagram of the study design (n: number of eyes). APACG: acute primary angle closure glaucoma; PACS: primary angle closure suspect; CPACG: chronic primary angle closure glaucoma; POAG: primary open angle glaucoma; CSC: central serous chorioretinopathy; SFCT: subfoveal choroidal thickness.