Alzheimer’s disease (AD) is the most common type of dementia, and is characterized by progressive memory impairment and cognitive decline (Roberson & Mucke, 2006). Mounting evidence has indicated that dementia attributed to synaptic dysfunction and neuronal loss in the hippocampus and its associated cortex (Youssef et al., 2008; Selkoe, 2002; Niikura et al., 2002; Scheff et al., 2007), which are caused by the accumulation of soluble Aβ oligomers (Rowan et al., 2007; Lacor et al., 2004; Haass & Selkoe, 2007). Aβ is the major constituent in senile plaques and cerebral amyloid angiopathy, which are two most distinctive histopathologies in AD. The accumulation of Aβ in the brain initiates a cascade of events, such as activating astrocytes and microglia, initiating inflammatory responses, which lead to oxidative injury, altering neuronal ionic homeostasis, kinases/phosphatase activities, and so on (Klafki et al., 2006). These cascades result in a wide range of neuronal/synaptic dysfunction and loss, as well as loss of neurotrophin retrograde transport, therefore causing patients to present with the symptoms of dementia. Adjustment of the pathological progress of amyloid peptide is a key strategy to slow down the AD progression. In addition to reduction of the Aβ levels in the brain (Klafki et al., 2006), the concomitant application of neuroprotective agents may be the alternative therapeutics for AD, and a strategy to prevent progressive synaptic and cognitive degeneration (Klafki et al., 2006). Neurotrophins (NT) are synthesized and secreted by the target tissue, and after binding to its receptors and transported in a retrograde manner to the cell body. They exert a wide range of actions, including neuronal survival and differentiation, modulation of neuronal excitability, development and maintenance of synapses and modification of synaptic structure and function (Poo, 2001). The application of neurotrophic factors such as BDNF and CNTF could enable the modulation of neuronal survival and synaptic connectivity (Lu, Christian & Lu, 2008; Garcia et al., 2010)