IGF-1R stimulates polarity switch of migrating neurons. (a) shRNA-IGF-1R (center) decreases the proportion of bipolar cells in the radial migration zone (RMZ) at E17 compared to a control vector (left). Co-electroporation of shRNA-IGF-1R and IGF-1 OPT rescued normal polarization (right). (b) Cell morphologies of shRNA-IGF-1R and control cells are shown at higher magnification at the RMZ and multipolar marginal zone MMZ Calibration bar = 50 μm. (c) Quantification of in the morphologies of cells located in the RMZ from a. Student’s t test; ***p-value = 0.002. n = 3 independent experiments. An average of 100 cells was scored for each condition.