Catalysis in nanogels: Nanogels have intrinsic properties that make them well suited for green chemistry [116–117]. Water-compatible gels are usually based on poly(N-isopropylacrylamide) (PNIPAM), poly(N-vinylcaprolactam) (PVCL) or other water-soluble polymers . For instance, PNIPAM is a thermo-responsive polymer, which has a lower critical solution temperature (LCST) of 32 °C. Above the LCST, individual polymer chains switch from a swollen coil configuration to a collapsed globular one, providing a nano-environment that is suitable for either hydrophobic or hydrophilic substrates . Water forces PNIPAM brushes to become hydrophobic, acting as a suitable environment for most organic reactions ; it allows hydrophobic substrates to diffuse towards the encapsulated catalysts, leading to a concentration effect that directly contributes to an efficient aqueous reaction .