LCModel (Provencher, 2001) was used to perform eddy current correction and to calculate metabolite ratios to creatine, as well as absolute concentrations using the water scaling method (Ernst et al., 1993; Kreis et al., 1993). SPM12 software was used to segment the MEMPRAGE regions corresponding to the SVS voxel into gray matter, white matter, and cerebrospinal fluid (CSF) for partial volume correction and water concentration calculation. Spectra were eliminated if the quality was poor (signal-to-noise ratio < 7, line width at half the peak maximum > 0.07 parts per million as reported by LCModel).