The setting in which patients would be engaged about open science research and the nature of informed consent mechanisms were key points of disagreement. Some interviewees favored engagement solely by treating physicians, while other advocated for a centralized location with dedicated staff. Likewise, some supported broad consent to maximize the future use of samples and data, while others said tiered or dynamic consent (Kaye, 2012) would ensure that the preferences of research participant were properly addressed. However, almost every interviewee emphasized the primacy of safeguarding both patient confidentiality and the autonomy to decline participation without prejudice.