We compared our data with historical data on endophthalmitis after cataract surgery to identify the differences of clinical presentation for endophthalmitis after cataract surgery versus vitrectomy. Table 3 shows the difference in clinical presentation between postvitrectomy and postcataract surgery endophthalmitis groups: 73.4% versus 50% patients in the postvitrectomy and postcataract surgery groups, respectively, presented within the first week (P = 0.006). Presence of fibrin was a finding in 93.3% patients in the postvitrectomy group compared to 72.5% patients in the postcataract surgery group (P = 0.004). Corneal edema and absence of red fundal glow (Grade 5) was more common in the postcataract surgery group compared to the postvitrectomy group (P = 0.001). Only 44.4% patients in the postvitrectomy group had normal intraocular pressure (IOP). Low and high IOP was recorded in 8.9% and 46.6% patients in the postvitrectomy endophthalmitis surgery group. This is in contrast to that reported by Endophthalmitis Vitrectomy Study (EVS), where normal IOP was seen in 80.6% of patients. Postoperative hypotony (defined by IOP < 7 mmHg) was seen in one (20%) patient in the MIVS group. Presence of corneal ulcer and scleral necrosis involving the sclerotomies were findings specific to this study.