With a median age of 64 years, glioblastoma (GBM) patients are in nearly half of cases at an age, that frequently defines them as “aged” or “elderly” [1, 2]. Generally, the present standard of care for GBM patients includes involved field radiotherapy (RT) as well as concomitant as well as 6 cycles of adjuvant chemotherapy with temozolomide (TMZ) and goes back to the study from Stupp et al. in 2005 . The patient cohort, however, was limited to an age of equal or less than 70 years and a post-hoc analysis of this cohort found a negative correlation between the patient’s age and the benefit from a combined regimen [3, 4]. An anticipated increased likelihood of adverse events of TMZ in elderly patients might be one explanation for this finding . Notably, several mono-institutional reports as well as data-base-studies have demonstrated that elderly GBM patients treated with standard-RT plus TMZ do have a longer survival compared to patients treated with alternative or reduced regimens, especially after extensive resection of the tumor [6–8].