Although, 2003 NIH/IRLSSG diagnostic criteria have defined RLS in a much more detailed way than those previous criteria. The same disadvantage still exist in this criteria, RLS “mimics” can’t be excluded according to this diagnostic criteria. Such as conditions like cramps, positional discomfort and local leg pathology. Then the diagnostic criteria were recently revised again by the IRLSSG in 2012 (International Restless Legs Syndrome Study Group, 2012). Comparing with 2003 NIH/IRLSSG diagnostic criteria, 2012 revised RLS diagnostic criteria have added an important essential criterion, noting that RLS should be differentiated with other conditions with similar symptoms such as myalgia, venous stasis, leg edema, arthritis, habitual foot tapping, and so on (International Restless Legs Syndrome Study Group, 2012). 2012 revised RLS diagnostic criteria also stated the stipulation of clinical course and clinical significance of RLS as presented (International Restless Legs Syndrome Study Group, 2012). The newest diagnostic criteria (Table 2) is much more rigorous than 2003 IRLSSG diagnostic criteria.