The simulations showed that, for a broad set of activity regimens, PCs generate BPRs modulated by the excitatory/inhibitory balance and by synaptic plasticity. The underlying BPR mechanism reflects modulation of intrinsic pacemaking by Ca/KCa currents generated in the dendritic compartment and transmitted to the soma and axon initial segment (AIS) through the internal resistance. Therefore, BPR emerges as a relevant coding strategy for PCs that could be modulated by spatio-temporal granule cell spike patterns and synaptic inhibition and plasticity, generating the specific outputs to be transmitted to DCN.