Streptozotocin (STZ), a glucosamine-nitrosourea compound, is a genotoxic methylating agent and preferentially destroys insulin-producing β cells of the pancreas through the generation of ROS and alkylation of DNA . STZ is a chemical used for the generation of diabetes phenotypes in most strains of rodents . A mouse model utilizing five doses of STZ at low dose (50–60 mg/kg/day) has been extensively used in studies of type 1 diabetes (T1D) due to the progressive destruction of pancreatic β cells induced . Importantly, the STZ-induced diabetes of mouse resulted in spatial learning deficits and impaired hippocampal long-term potentiation (LTP), which is thought to affect the cellular mechanisms of learning and memory . Accordingly, STZ-treated mice have been used extensively to examine the physiological and pathophysiological consequences of diabetes-induced dementia.