The evolution of classical resistance is the expected result of using chemical interventions to kill parasites (or, in evolutionary terms, reduce their fitness), but, as we have shown, failing to consider the potential for nonclassical resistance, like life history evolution, can yield overly optimistic predictions about the epidemiological or clinical effects of those interventions. Similarly, Lynch, Grimm, and Read (2008) used models to investigate the influence of different antihelminth interventions on nematode life history, finding that disease control programs may frequently select for increasingly fecund worms, with ramifications for clinical outcomes and onward transmission. In an experimental system, filarial nematodes altered their reproductive schedules in the presence of specialized immune cells, producing transmissible stages faster and in greater numbers (Babayan, Read, Lawrence, Bain, & Allen, 2010). As these are the same immune cells on which current experimental vaccines rely, this work suggests that nematodes could reduce the benefits of vaccination through plasticity in life history. Further, the mosquitoes that transmit malaria and other diseases can also respond to intervention efforts with nonclassical resistance, including, for example, changes in feeding behaviour or timing to avoid insecticide‐treated bednets (Gatton et al., 2013; Sokhna, Ndiath, & Rogier, 2013).