Z.B.M., N.F., M.C.C., M.H., P.C., G.M., A.V.-B., A.P.M., L.M., and P.M. performed experiments; Z.B.M., N.F., T.J.P., M.C.C., M.H., P.C., G.M., A.P.M., and G.A.R. analyzed data; Z.B.M., N.F., T.J.P., and G.A.R. interpreted results of experiments; Z.B.M., T.J.P., and M.C.C. prepared figures; N.F., T.J.P., M.C.C., M.H., P.C., G.M., A.V.-B., A.P.M., L.M., and P.M. approved final version of manuscript; A.V.-B. and P.M. edited and revised manuscript; G.A.R. conception and design of research.