This study was performed on 35 male SD rats with weight of 200–250 g from Shanghai SLAC Laboratory Animal Co. Ltd. (Shanghai, China), housed in regular cages, situated in an animal room at 22 ± 2°C and maintained on a 14-hour light/10-hour dark cycle. The rats were randomly divided into 4 groups as follows: Group I (n = 5), serving as controls, were maintained in a standard normoxic chamber (FiO2 0.21). Group II (n = 10) rats were injected with 40% CCl4 (the mixture of CCl4 and olive oil) in a standard normoxic chamber (FiO2 0.21). Group III (n = 10) rats were injected with 40% of CCl4 mixture in normobaric hypoxic chamber (FiO2 0.07) with hypoxia exposures 8 hours each day. Group IV (n = 10) were modeled in the same manner as Group III (40% CCl4 mixture injection plus hypoxia exposures) but treated with PPARγ agonist rosiglitazone (RSG). RSG was added to the liquid diet at a daily intake of 10 mg/kg body wt for feeding.