The impact on HRQoL was greater with pattern A than B multimorbidity score. The greatest effects were found with the Duke Health Profile. A high pattern A score was associated with a lower score in both mental and physical dimensions of HRQoL and a high pattern B score was essentially associated with a lower score in the physical dimension. Indeed, no significant association was found between mental HRQoL score and pattern B score. Pattern B is related to cardiovascular and metabolic disorders. The literature showed that cardiovascular diseases were associated with a reduced in physical and mental dimensions of HRQoL . In addition, a strong association was found between depression and cardiovascular diseases . So we could have expected in our study a significant impact of pattern B multimorbidity score on mental HRQoL. In the absence of this result, we can make the hypothesis that our method allows us to better identify participants with cardiovascular pathology in absence of psychological disorders. In fact, anxiety/depression condition is represented in pattern A.