These results could be verified in the B16-EpCAM model, although the absolute survival rates cannot be compared in the two models. Therapy with either the trAb BiLu or the anti-CTLA-4 mAb HB304 alone yielded identical survival benefits in comparison to the tumor control group. This effect could be improved by combining both therapy regimens resulting in a prolongation of the median survival and an increase of long-term survivors from 20 to 40% (Figure 3C).