(−)-α-Bisabolol is an unsaturated sesquiterpene alcohol that occurs naturally in the Brazilian candeia tree (Eremanthus erythropappus) and in medicinal herbs such as German chamomile (Matricaria recutita) [9, 10]. It has been shown to have pharmaceutical functions (e.g., antibacterial, antiseptic, and anti-inflammatory activities), and skin-soothing and -moisturizing properties [11–13]. Owing to the low toxicity associated with (−)-α-bisabolol, the Food and Drug Administration (FDA) has granted it the Generally Regarded as Safe (GRAS) status that has promoted its use as an active ingredient in several commercial products . At present, natural (−)-α-bisabolol is primarily manufactured through the steam-distillation of candeia essential oils extracted from the Brazilian candeia tree, which has raised environmental and bioconservation issues in recent years . (−)-α-Bisabolol can also be chemically synthesized; however, chemical synthesis requires an additional economically unviable purification step because of the formation of other diastereomers ((+)-α-bisabolol and (±)-epi-α-bisabolol) and undesirable byproducts . Therefore, a sustainable supply of nature-identical (−)-α-bisabolol is essential to specialty chemical industries. Recently, a (−)-α-bisabolol synthase capable of synthesizing enantio-selective (−)-α-bisabolol as a single terpenoid product has been identified in German chamomile. (−)-α-bisabolol synthase was expressed in Saccharomyces cerevisiae for the production of (−)-α-bisabolol and had a yield of 8 mg/L after 4 days of cultivation . This previous study has paved the way for the biological production of enantioselective (−)-α-bisabolol in engineered microorganisms, but the productivity is very low for industrial production of (−)-α-bisabolol.