2) The comment in the Discussion section: "The 4.5 Å cryoEM structure of the PLY pore complex thus paves the way towards the design of new drugs that inhibit toxin oligomerization and pore formation as a promising approach towards combating infections by wide-spread and dangerous Gram-positive pathogens" jars with the reply "the different CDCs seem to follow different pathways of pore formation…. Any more discussion of PFO papers would distract from the main focus of our work, which is on PLY." Therefore, the authors should focus the therapeutic claim focus to diseases that PLY has shown to contribute.