For MDA, the juvenile age category had the largest (3.42 SMD, 95% CI, 2.75 to 4.08) and mature animals the smallest (2.12 SMD, 95% CI, 0.14 to 4.10) change in MDA levels (χ2 for difference = 335.91, Τ2 = 1.90, I2 = 80.6%, d.f. = 65, p<0.0005; Fig 5A). The Balb/c strain showed the largest (9.15 SMD, 95% CI, 1.53 to 16.78) and Swiss Albino the smallest (0.53 SMD, 95% CI, 0.05 to 1.12) change in MDA level (χ2 = 335.91, Τ2 = 1.90, I2 = 80.6%, d.f. = 65, p<0.0005; Fig 5B). Duration of administration of 60–112 days had the largest (3.74 SMD, 95% CI, 2.55 to 4.93) and 7–40 days the smallest (1.52 SMD, 95% CI, 0.76 to 2.28) change in MDA level (χ2 = 283.09, Τ2 = 1.73, I2 = 78.8%, d.f. = 60, p<0.0005; Fig 5C). We found no significant impact of the route of administration, drug dose category, animal gender and rodent type on the change in MDA level.