TERT siRNA (#sc-36641) and negative control siRNA (#sc-37007) were purchased from Santa Cruz Biotechnology. MYC esiRNA (#EHU021051) and esiRNA targeting EGFP (negative control, #EHUEGFP) were purchased from Sigma-Aldrich. These siRNA were transfected to cells using Lipofectamine RNAiMAX Reagent (Invitrogen) according to the manufactory’s protocol. Cells were harvested 2 days after transfection and the knockdown efficiency was determined by western blotting. Transfected cells were subjected to functional analyses.