Bioinformatics predictions - For the computational analysis, we followed a strategy established in our laboratory (Castillo et al. 2016). Briefly, the sequences of DENV-1 to -4 were downloaded from GenBank, and the free algorithm MicroInspector (www.ncbi.nlm.nih.gov/pmc/articles/PMC1160125/) was used to scan for possible targets of human miRNAs collected in miRBase. Only those target sites common to the four reference sequences were selected. The RNAhybrid program (http://bibiserv.techfak.uni-bielefeld.de/rnahybrid/) was used to verify the findings of MicroInspector.