Analysis of the secretome, or proteins produced by HCMV-infected cells, has revealed high levels of both MMP-3 and PAI-1 , which is consistent with our observations that cmvIL-10 induces higher expression of both of these proteins. The secretome was found to promote angiogenesis and wound healing, and contained many growth factors, cytokines, chemokines, and enzymes associated with metastasis, including MMP-1, MMP-2, MMP-9, and MMP-10 . Somiari and colleagues were able to detect elevated levels and activity of MMP-2 and MMP-9 in plasma from breast cancer patients, as well as in women determined to be high risk based on Gail Model predictions . This suggests that it may be possible to develop a plasma protein profile with a characteristic signature that identifies individuals likely to develop breast cancer.