Comparing with the previous diagnostic criteria, 2012 revised RLS diagnostic criteria is the only criteria that developed by a large international number of RLS clinical and research experts through an interdisciplinary, international and evidence-based approach which ensure it to be a world-wide consensus criteria which reduces the risk of cultural bias and avoids arbitrary and improve the validity. The specifiers for clinical course and significance are able to provide a method to define different target population which would help clinicians and researchers to offer better prevention and treatment strategies for specific groups of patients and to better elucidate etiopathogenesis (Allen et al., 2014).