Heavy metals include lead, nickel, cadmium, and so on. In 2013, Williams, M. et al. found heavy metals such as tin, nickel, lead, chromium and other nanoparticles in the smoke of E-cigarettes . The inhaled heavy metal nanoparticles can be deposited in the alveoli, inducing lung damage and leading to cough, dyspnea, chest pain, pulmonary edema, acute respiratory failure, as well as carcinogenicity, nephrotoxicity, and neurotoxicity . For example, tin is cytotoxic to human lung fibroblasts . In 2017, Williams, M. et al. continued to study the electronic flue gas sol. They selected 36 kinds of elements to detect, of which 35 kinds were detected in the electronic flue gas sol, while there were only 15 kinds of heavy metals detected in traditional cigarettes. These elements contain a variety of heavy metals, and the concentration is usually higher than that of traditional cigarette smoke . The content of lead and chromium is equal to that of traditional cigarette smoke. Especially the nickel content is much higher than that of traditional cigarettes . However, we still do not know the effects of inhaling heavy metal particles in aerosol on health.