The differential surface tension of a tamponading agent compared to balanced salt solution helps to seal the sclerotomy wounds, minimizing hypotony and associated infections.[17–19] Although this study has not been designed to show the association of use of tamponade and endophthalmitis, we found absence of tamponading agent in all cases with endophthalmitis (n = 5) who underwent MIVS where sclerotomies were self sealing. Park et al. in their series found that vitrectomy for retinal detachment was associated with reduced risk of infection. They suggested that as in these cases the use of a tamponading agent probably results in better wound integrity.