Overall glycosylation changes throughout pregnancy and the postpartum period shown in boxplots. Displayed are the glycan traits related to antennarity (top row), and the glycosylation traits likely to be of immunoglobulin origin (bottom row) (15, 26). Depicted are healthy controls (in white) and patients with rheumatoid arthritis (RA) (in gray) at preconception (pc), trimesters 1 through 3 (tm1, tm2, tm3), 6 weeks postpartum (pp1), 12 weeks postpartum (pp2), and 26+ weeks postpartum (pp3). CA2, diantennary species within complex type; CA3, triantennary species within complex type; CA4, tetraantennary species within complex type; A2S0F, fucosylation of non-sialylated diantennary species; A2FS0G, galactosylation of non-sialylated fucosylated diantennary species; A2FSB, bisection of sialylated fucosylated diantennary species. Red brackets indicate statistically significant findings between time points (horizontal), or between healthy individuals and RA patients (vertical).