Previously, we coined the term ‘atopobiotic’ microbes to describe microbes that appear in places other than where they should be, e.g. in the blood, forming a blood microbiome . Here, we suggest that the metabolic and cell membrane products of these atopobiotic microbes correlate with, and may contribute to, the dynamics of a variety of inflammatory diseases [64–67], and that LPS, in addition to (possibly low-grade) long-term inflammation via cytokine production, may lead an acute and direct hypercoagulatory effect by binding to plasma proteins, especially fibrinogen. Specifically, we showed here that, even with very low levels and highly substoichiometric amounts of LPS, a greatly changed fibrin fibre structure is observed. An urgent task now is to uncover the mechanism(s) of this acute and immediate effect, with its remarkable molecular amplification.