The sequelae of NTDs are staggering and appear to have not only anatomical effects secondary to the primary defect but also functional, emotional, and psychological morbidities including bladder and bowel incontinence, paralysis, musculoskeletal deformity, and shunt malfunctions and infections, among others. Moreover, the costs involved in maintenance of spina bifida patients include mobility aids (orthoses, wheelchairs, and crutches), medications, and the cost associated with shunt revisions, in addition to the cost of modifications to public utilities that are required to enable disabled access. Ultimately, its compound nature results in an immense financial burden amounting to $1,400,000 per child affected by NTD over a 20-year life span [139–142].