Besides the breast shape and composition, it is also important to characterize the tumor location and size. Since the relationship between tumor position and the aesthetical outcome is generally defined using breast quadrants to discretize tumor locations, tumors are randomly positioned inside each quadrant instead of choosing any position inside the breast, which assures the representativeness of the dataset by guarantying that there are instances of tumors in every quadrant. There are 4 quadrants defined by a vertical and horizontal division of the breast through the nipple and in the upright position (Figure 4): Upper-Outer or superolateral Quadrant (UOQ), Upper-Inner or superomedial Quadrant (UIQ), Lower-Outer or inferolateral Quadrant (LOQ), Lower-Inner or inferomedial Quadrant (LIQ) .