Incongruent with the hypothesis, we did not find the GMV of the ventral striatum correlating with the IAT score. The ventral striatum is a critical region related to the addiction, and usually presents abnormal activation in individuals with addiction (26, 27). In our study, we focused on adolescent online game players but not only the IGD individuals, which might be a possible explanation to the negative result of ventral striatum. However, this negative result should be verified in the future study with large sample size.