To investigate the value of NGAL for distinguishing between WRF with good and poor outcomes, we examined NGAL and creatinine trajectories (Figure 3) in patients who experienced WRF (or not) who had died, or were alive, after 180 days. Baseline plasma NGAL was higher and rose further in patients who died compared to survivors, and was higher in patients with WRF, irrespective of outcome. The pattern was similar when the 60-day endpoint was examined. In mutually adjusted models, including NGAL and Creatinine, NGAL was a stronger predictor of WRF with a poor outcome, and improved the model when added to creatinine, showing consistently higher Goodness of Fit (Table 4).