All data are presented as mean ± SEM. Descriptive statistics for continuous parameters consisted of median and range, and categorical variables were expressed as percentages. Comparisons between patients and healthy controls were carried out by the Mann–Whitney U test with a Welch post-test correction. Statistical significance in multiple comparisons was by one-way analysis of variance (ANOVA) with a Dunn’s post-test correction. P values <0.05 were considered statistically significant. Data were processed in GraphPad Prism version 6.0 for MacOSX (GraphPad Software Inc.).1 Andreas Schoetzau provided professional statistical assistance.2