The Data are presented as the means ± SEM of the indicated number of experiments and analyzed using ANOVA; post hoc testing was performed using the Bonferroni modification of the t-test. The individual studies performed throughout this work represent at least five independent studies. Power analyses were performed by using a Type I error probability of 0.05, with a power of 0.9, to determine the sample size necessary to reject the null hypothesis. All statistical analyses were carried out using the GraphPad Prism 5 program.