For behavioral analysis, experimental groups were composed of 12 to 15 sex-matched. General motor behavior was assessed using an open field task. A white square box divided in four compartments (50 × 50 × 37 cm) was used to monitor the spontaneous activity of four mice simultaneously. Under dim and dispersed light conditions, each mouse was placed in the center of the arena and allowed to move freely for 10 min. Various parameters including the total distance moved were analyzed using an Ethovision XT (Noldus) tracking system.