Compared with the sham group, the escape latency of the model group was significantly prolonged in the navigation test, and the explored distance in the target area was decreased in the spatial probe test. After treatment for 14 days, the escape latency of the DNLA group was decreased and the explored distance in the target area was increased as compared with the model group. The results indicated that DNLA could protect the mice against learning and memory deficits which were induced by Aβ25–35 injection (Fig. 2).