Effects of Railway Vibration on Sleep and Disease
This study will investigate the biological mechanisms linking sleep disruption by vibration and noise, and the development of cardiometabolic disease. In a laboratory sleep study, the investigators will play railway vibration of different levels during the night. The investigators will also measure objective sleep quality and quantity, cognitive performance across multiple domains, self-reported sleep and wellbeing outcomes, and blood samples. Blood samples will be analyzed to identify metabolic changes and indicators of diabetes risk in different nights. Identifying biomarkers that are impacted by sleep fragmentation will establish the currently unclear pathways by which railway vibration exposure at night can lead to the development of diseases in the long term, especially metabolic disorders including diabetes.
- EligibilityCriteria: Inclusion Criteria:  1) live in or around the city of Gothenburg area (Sweden)  Exclusion Criteria:  aged <18 or >30 years; habitual sleep and wake timings more than ±1 hour different from the study sleep times (i.e. habitual sleep time should be 22:00-00:00 and habitual wake time should be 06:00-08:00); BMI>25 kg/m2; regular sleep medication use (prescribed or "over-the-counter"); poor hearing acuity (measured during screening via pure tone audiometry); diagnosed with sleep disorders; diagnosed with diabetes indications of sleep apnea on the STOP-BANG questionnaire; shift work; smoking, vaping, snus, or other nicotine use; pregnant or breastfeeding - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge: 30 Years - StdAgeList: Adult