Oral Bioavailability of a New Formulation of Pterostilbene Cocrystal in Comparison With Its Free Form (BIOPTERO2)
The goal of this interventional study is to to evaluate the oral bioavailability of the crystallized form of pterostilbene (ccPT) compared to its commercial free base form (pterostilbene (PT) in healthy volunteers. The main question it aims to answer are:

• Do the crystallized forms of pterostilbene (ccPT) using two different encapsulation methods exhibit greater bioavailability than its commercial free base form (PT)?

Participants will attend to four visits: a preselection visit (V0), a visit for the first postprandial study (V1), a visit for the second postprandial study (V2) after one-week washing period and a visit for the third postprandial study (V3) after another one week washing period.

Researchers will analyze the three postprandial assays to determine which type of ccPT encapsulation provides the highest bioavailability compared to the commercial free base form (PT).
- EligibilityCriteria: Inclusion Criteria:  Men and women between 18 and 65 years of age. Sign the informed consent form. Know how to read, write and speak Spanish  Exclusion Criteria:  Take supplements or multivitamin supplements or phytotherapeutic products (especially infusions) that interfere with the treatment under study up to 30 days before the start of the study. Be lacto-vegetarian, lacto-ovo-vegetarian, or vegan. Present intolerances and/or food allergies related to pterostilbene or the excipients. Be a smoker. Having received antibiotic treatment up to 30 days before the start of the study. Present values of body mass index ≤ 18kg/m^2 or ≥ 35 kg/m^2. Present some chronic disease with clinical manifestations: coronary heart disease, cardiovascular disease, diabetes, celiac disease, Crohn's disease, chronic kidney disease, cancer, autoimmune diseases (such as fibromyalgia), respiratory and/or gastrointestinal diseases that may compromise the absorption of the compound. Clinical history of anemia. Being pregnant or intending to became pregnant. Be in breastfeeding period. Being unable to follow the study guidelines. Participate in or have participated in a clinical trial or nutritional intervention study in the last 30 days before inclusion in the study. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: Male - MinimumAge: 18 Years - MaximumAge: 65 Years - StdAgeList: Adult, Older Adult