Clinical-functional Effects of Bariatric Surgery on the Musculoskeletal System in Relation to Bone Turnover.
By studying "in vivo" new possible predictive factors of increased bone turnover and risk of fractures after bariatric surgery, our study aims to improve health not only musculoskeletal but general of patients with severe obesity, a pathology which represents one of the main causes of disability and mortality.
- EligibilityCriteria: Inclusion Criteria:  Age ≥ 18 and ≤ 60 years. BMI (Body Mass Index: expressed as weight ratio in kg/height in m2) ≥ 35 kg/m2 with comorbidities or BMI ≥ 40 Kg/m2 without comorbidities. Absence of diagnosis of primary obesity. Absence of medical-psychiatric contraindications. Previous diet therapy and/or pharmacological history verified. Signing of the informed consent for the study. Patients who are clinical candidates for bariatric surgery (Sleeve Gastrectomy and Roux-en-Y Gastric Bypass).  Exclusion Criteria:  Presence of chronic diseases of the digestive system, such as chronic intestinal diseases, malabsorption syndrome, diverticulosis of the colon. Current pregnancy and/or breastfeeding via self-declaration. Subjects suffering from endocrine pathologies (e.g. Cushing's disease, uncontrolled thyroid disease). Presence of known renal insufficiency or creatinine levels above 1.8 mg/dl and eGFR < 60 ml/min. Presence of chronic liver disease or ALT and AST levels above two standard deviations from normal levels. Presence of malignant pathology. Alcohol or drug abuse. Previous bariatric surgery. Severe psychological-psychiatric disorders. Difficulty adhering to the protocol due to language barriers or other reasons. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 60 Years - StdAgeList: Adult