Topical Nitro or Placebo Pre-Cath
Phase 2, single-center, randomized, blinded clinical study to assess the safety and efficacy of topical nitroglycerin on ease of TRA during scheduled PCI. We will compare topical nitroglycerin to placebo applied prior to planned, non-urgent PCI to determine if nitroglycerin is associated with decreased number of arterial puncture attempts made, decreased time to radial access, and lower crossover rate to TFA. Subjects will be randomized to receive either topical nitroglycerin ointment or placebo prior to scheduled PCI. There will be 256 subjects enrolled in this study with 1:1 randomization.
- EligibilityCriteria: Inclusion Criteria:  Male or non-pregnant female > 18 years of age at the time of consent Scheduled to undergo PCI using TRA in the cardiac catheterization laboratory Able to provide informed consent with capacity, given in English.  Exclusion Criteria  Patients with any of the following characteristics or conditions will not be included in the study:  Known nitrate allergy Allergy to CeraVe Moisturizing lotion Baseline hypotension with systolic blood pressure <90mmHg Absence of radial artery blood flow in one or both arms Presence or history of liver, rheumatologic, or chronic kidney disease Current treatment with any vasodilator therapy (eg. Sildenafil) Radial artery catheterization <30 days prior to enrollment Active site infection AV-fistula or prior radial artery harvest for bypass surgery - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult