Effect of Oral Feeding in Infants With Pierre Robin Syndrome
This was a randomized controlled study. The infants enrolled were randomly divided into the IOE group (with Intermittent Oro-Esophageal Tube Feeding) and the PNG group (with Nasogastric Tube Feeding), all receiving systemic therapy. Before and after 4-week treatment, pulmonary infection, swallowing function, nutritional status and body weight between the two group were compared.
- EligibilityCriteria: Inclusion Criteria:  meeting the diagnostic criteria for Pierre Robin sequence based on CT and X-ray examinations, combined with clinical manifestations and physical signs. with spontaneous vaginal birth, aged 1 to 12 months. with dysphagia screened by the water drinking test and further confirmed by the assessment of Dysphagia Disorders Survey (DDS), Dysphagia Severity Scale (DSS), or Schedule for Oral Motor Assessment (SOMA) before the treatment, the tube feeding was required and feasible after evaluation. stable vital signs. with nasogastric tubes placed before the treatment. sufficient human milk could be provided by the mothers of the patients (with the help of a manual suction device).  Exclusion Criteria:  abnormalities in brain development or other neurological lesions revealed by CT or MRI scans. dysphagia caused by other diseases. other congenital malformations, such as Down syndrome, cleft lip, and palate, etc. severe systemic disease (such as severe infection, severe hepatic and renal dysfunction). participants who need to receive other therapy which would potentially affect the result of this study - HealthyVolunteers: No - Gender: All - MinimumAge: 1 Month - MaximumAge: 12 Months - StdAgeList: Child