Association Between Lifetime Physical Activity and Exercise and the Development of Wild-type Transthyretin Amyloid Cardiomyopathy
The aim of this study is to investigate the association between increased lifetime physical activity and the development of wild-type transthyretin amyloid cardiomyopathy.
- EligibilityCriteria: Inclusion Criteria:  Confirmed diagnosis of wtATTR-CM including sequencing of the TTR gene; or HFpEF; or HFrEF; or healthy proband without a diagnosis of heart failure Initial diagnosis of respective cardiac disease (wtATTR-CM, HFpEF, HFrEF) after the 6th decade of life; or no cardiac disease (healthy control) Willingness and ability to provide signed informed consent form (ICF) Age > 60 years  Exclusion Criteria:  History of severe chronic illness limiting the ability to perform physical activity during the 3rd to 6th decade A diagnosis of dementia or cognitive impairment Any other reason resulting in the inability to perform the questionnaire and/or interview - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 60 Years - StdAgeList: Adult, Older Adult - StudyPopulation: Number of participants: 252 The study population will comprise four subgroups (n=63 in each group)  cardiac wild type transthyretin amyloidosis (wtATTR-CM); heart failure with preserved ejection fraction (HFpEF); heart failure with reduced ejection fraction (HFrEF; ischemic or inflammatory origin); healthy controls - SamplingMethod: Non-Probability Sample