Kidney Transplantation From Donors With HIV: Impact on Rejection and Long-Term Outcomes (Expanding HOPE Kidney)
This research is being done to better understand rejection in transplant recipients with HIV who receive kidneys from donors with vs without HIV.
- EligibilityCriteria: Inclusion Criteria:  Participant meets local criteria for kidney transplant. Participant is able to understand and provide informed consent. Participant has documented HIV infection by any licensed assay or documented history of detectable HIV-1 RNA. Participant is ≥ 18 years old. Cluster of differentiation 4 (CD4+) T-cell count: ≥ 200/μL within 16 weeks of transplant. HIV-1 RNA < 50 copies/mL. Viral blips between 50-400 copies will be allowed as long as there are not consecutive measurements > 200 copies/mL. Participant is not suffering from significant wasting (e.g. body mass index <21) thought to be related to HIV disease. Participant meets with an independent advocate.  Exclusion Criteria:  Participant has prior progressive multifocal leukoencephalopathy (PML), cryptosporidiosis of > 1 month, or primary central nervous system (CNS) lymphoma. Participant is pregnant or breastfeeding. Past or current medical problems or findings from medical history, physical examination or laboratory testing that are not listed above, which, in the opinion of the investigator, may pose additional risks from participation in the study, may interfere with the participant's ability to comply with study requirements or that may impact the quality or interpretation of the data obtained from the study. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult