Effectiveness of Gut Microbiota-targeted Dietary Intervention Among HIV-infected Patients
The goal of this clinical trial is to conduct a dietary intervention targeting HIV-specific gut microbiota alterations for primary ASCVD prevention and evaluate its effectiveness in preventing borderline ASCVD risk among HIV-infected patients. The main questions it aims to answer are:

Explore the pivotal role of the gut-heart axis in the causal relationship between HIV infection and atherosclerotic cardiovascular disease.
Develop a targeted dietary intervention focusing on gut microbiota to prevent the borderline risk of atherosclerotic cardiovascular disease in HIV-infected patients.
Evaluate the effectiveness of the gut microbiota-targeted dietary intervention in reducing atherosclerotic cardiovascular disease risk among HIV-infected patients, altering gut microbiota composition, improving risk factors of atherosclerotic cardiovascular disease, and alleviating prodromal symptoms associated with atherosclerotic cardiovascular disease.

Participants in the intervention group will receive the gut microbiota-targeted dietary intervention thrice weekly for 3 months, accompanied by bi-weekly health education videos for the same duration. Meanwhile, the control group will continue routine follow-up and health education practices. The intervention will span three months, followed by a three-month follow-up period. Data collection will occur at baseline, 3 months, and 6 months.
- EligibilityCriteria: Inclusion Criteria:  HIV-infected patients diagnosed according to the diagnostic criteria of China AIDS diagnosis and treatment guidelines (2021 edition); Aged 18 years and above; PCE predicted ASCVD risk of 5% - <7.5%; Those with a predicted survival time of >1 year; No plans to leave the depth in the next 3 months; Voluntary participation in this study and signing the informed consent.  Exclusion Criteria:  Those with a past history of CVD; Those with HIV-related neurocognitive disorders and various serious opportunistic infections; Those with diabetes mellitus; Known nut allergy; Planning to become pregnant within 6 months; Are on lipid-lowering therapy or using any interfering medications or diets; Are participating in other HIV-related or dietary intervention-related scientific research programs. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult