Preventing Exercise Resistance With Sedentary Interruptions
The goal of this randomised cross-over trial is to learn about the interaction between sedentary behaviour throughout the day and the metabolic effect of an exercise bout on that same day in office workers with an increased risk for chronic disease.

The main question this study aims to answer is if the lipid-lowering effects of an exercise bout can be more pronounced by implementing alternations between a seated and a standing working position throughout the day.

Participants will be asked to:

Complete three intervention periods for a duration of 2 days at their workplace,
Attend a supervised training session (60min) at the research facility at the end of each intervention period,
Attend three assessment days at the research facility where postprandial metabolism will be evaluated after a standardised meal test.
- EligibilityCriteria: Inclusion Criteria:  between 30 and 65 years old, primarily work in an office environment for at least 0.75 full time equivalents, sedentary (on average >9h of sedentary time per day, assessed objectively), at an increased risk for disturbances in lipid profile (assessed with fingerstick (Analox®) total cholesterol >200 mg/dL or fingerstick triglycerides >150 mg/dL), written informed consent to participate in the study.  Exclusion Criteria:  medical conditions precluding physical activity (PA) participation, abusive alcohol intake (>20 units/week), pregnant or intention to become pregnant, change in dietary habits or weight loss (>2kg) in the last month before the study, a diagnosis of cardiometabolic diseases such as diabetes mellitus or cardiovascular diseases. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 30 Years - MaximumAge: 65 Years - StdAgeList: Adult, Older Adult