Dexmedetomidine and Vasopressin in Septic Shock
Rudiger and Singer suggested strategies for refining adrenergic stress (decatecholaminization). They proposed the use of dexmedetomidine and vasopressin to reduce the catecholamine load during sepsis. The investigators will use vasopressin as the primary vasopressor and a heart rate-calibrated dexmedetomidine infusion in septic shock patients.

The investigators of the current study will use DEXPRESSIN in septic shock patients to investigate the effects of decatecholaminization on in-hospital mortality.
- EligibilityCriteria: Inclusion Criteria:  Adult patients who develop septic shock in whom a vasopressor is initiated to maintain a mean arterial blood pressure (MAP) of ≥65 mmHg in the presence of sepsis (≥2 SIRS criteria plus suspicion or confirmation of infection).  Exclusion Criteria:  Patient refusal or inability to obtain consent Failure of hemodynamic stabilization or hemoglobin <7 g/dL at the time of inclusion Severe cardiac dysfunction [i.e., ejection fraction (EF) <30%] History of heart block or patient on pacemaker Severe valvular heart disease Chronic liver disease (Child-Pugh classification C) Pregnancy Patients with traumatic brain injury - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult