Lymphatic Phenotype in Noonan Syndrome Spectrum Disorders
To get a better insight into the central conducting lymphatic system in adult volunteers with Noonan Syndrome (NS) without clinical symptoms or signs of lymphatic disease compared to NS and CardioFacioCutaan syndrome patients with severe lymphatic disease
- EligibilityCriteria: Inclusion Criteria:  Noonan Syndrome confirmed by genetic test with a class 4 or 5 pathogenic variant according to ClinVar 18 years and older (no restriction for sex) Willing and able to have MR lymphangiography scanning in the Radboudumc Oral and written informed consent None of the exclusion criteria  Exclusion Criteria:  unsuitable for MRI (e.g. metallic objects in the body, severe claustrophobia)  A history of symptoms related to lymphatic disease pregnancy renal insufficiency liver cirrhosis History of surgery related to cardiovascular disease with hemodynamic consequence Other genetic diseases - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult