Coagulation Activation in Patients With Pemphigus
Aim of work:

To evaluate the plasma markers of coagulation activation: prothrombin F1+2 and d-dimer levels in pemphigus patients with active disease and compare them with age and sex-matched controls.
To evaluate the correlation of these markers with disease severity score by using Pemphigus Disease Area Index (PDAI) and with disease activity by measurement of anti-desmoglein 1 and 3 antibody titers.
- EligibilityCriteria: Inclusion Criteria:  pemphigus vulgaris patients at active stage of the disease. patients between the ages of 18 and 60.  Exclusion Criteria:  Patients with other autoimmune bullous diseases. Patients with other skin diseases. Patients with chronic liver, renal or haematological diseases. Patients with malignant tumors. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge: 60 Years - StdAgeList: Adult - StudyPopulation: Patients with active pemphigus who are either in a relapse for less than a week or are newly diagnosed cases will be included. The active stage of PV is defined as the de novo development of blisters on a healthy (unaffected or healed) site of either the skin or the mucous membrane.  Clinical assessment, histopathological analysis (acantholysis and intraepidermal splitting) will be used to confirm the diagnosis of each patient.  Control group: Healthy age and sex-matched subjects, who are free of chronic systemic diseases or dermatological conditions, will be enrolled as control. - SamplingMethod: Non-Probability Sample