A Study on the Correlation Between Endometriosis and Intra-tissue Microbiota
Endometriosis (EM) is a common gynecological condition, but the pathogenesis of it has not yet been clarified. Here, the investigators wanted to investigate the correlation between endometriosis and the intra-tissue microbiota. The investigators planed to collect serum, vaginal swabs, cervical mucus, feces, peritoneal fluid, and endometrial tissue for sequencing and experiments.
- EligibilityCriteria: Inclusion Criteria:  Women aged 18-52 years old. Regular menstruation with a cycle of 28-35 days. No sexual intercourse 1 week before the operation. No systemic or local use of antibiotics and probiotics for 6 months prior to surgery. No history of acute or chronic pelvic inflammatory disease. Subjects fully understand the significance of the study and sign the informed consent form.  Exclusion Criteria:  In pregnancy. Intraoperative conditions or pathological examination suggest a malignant or junctional disease. Severe anatomical abnormalities of the pelvis. Pelvic contamination with large amounts of blood during laparoscopic operation. History of gene therapy, blood transfusion, stem cell therapy, or bone marrow transplantation Psychiatric, personality disorders, or abuse of psychoactive substances. Immunodeficiencies, allergies, or autoimmune diseases. Contraindications to endotracheal intubation anesthesia. Absolute or relative contraindications to laparoscopic or hysteroscopic surgery. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: Female - MinimumAge: 18 Years - MaximumAge: 52 Years - StdAgeList: Adult - StudyPopulation: Participants in this study will be recruited in the obstetrics and Obstetrics and Gynecology Medical Center of Zhujiang Hospital. With reference to the inclusion and exclusion criteria, patients admitted for surgery were under screening. - SamplingMethod: Non-Probability Sample