Molecular Endotype-Specific Dynamics of Lung Endothelial Barrier Integrity in Sepsis
Sepsis is a complex syndrome that causes lethal organ dysfunction due to an abnormal host response to infection. No drug specifically targeting sepsis has been approved. The heterogeneity in sepsis pathophysiology hinders the identification of patients who would benefit, or be harmed, from specific therapeutic interventions. Recent clinical genomics studies have shown that sepsis patients can be stratified as molecular endotypes, or subclasses, with important clinical implications. Classifying sepsis patients as molecular endotypes revealed that a poor prognosis endotype was characterized by immunosuppression and septic shock. Against this backdrop, the study hypothesis is that a poor prognosis for sepsis is defined by a molecular endotype reflecting impaired innate immune and endothelial barrier integrity in the primary anatomical site of infection.
- EligibilityCriteria: Inclusion Criteria:  Age ≥ 18 years Acute respiratory tract infection due to community- or hospital-acquired pneumonia  Exclusion Criteria:  Consent card not signed Pregnancy Prisoners Aspiration pneumonitis Patients with ventilator-associated pneumonia - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult - StudyPopulation: Sepsis secondary to community- or hospital-acquired pneumonia - SamplingMethod: Non-Probability Sample