Hydroxytyrosol Dietary Supplement and Prevention of Age-Related Diseases
The primary objective of this study is to ascertain the effects of chronic consumption of a hydroxytyrosol-rich extract from olive (Hytolive®) in a population at high risk of developing age-related pathologies such as type 2 diabetes and cardiovascular diseases. The markers measured will be associated with oxidative stress, inflammation, and homeostasis glucose and lipid profiles. Improvements in these parameters could potentially prevent the onset of pathologies associated with aging.
- EligibilityCriteria: Inclusion Criteria:  Prediabetes (defined as fasting glucose levels according to the American Diabetes Association guideline, with fasting blood glucose ≥100 and <126 mg/dL, or hemoglobin A1c levels ranging from 5.7% to 6.4%) Overweight (body mass index BMI 24-29.9 kg/m2)  Exclusion Criteria:  Any prior diagnosis of diabetes, hypertension, hyperlipidemia, other cardiovascular diseases, thyroid gland disorders, asthma, arthritis, or inflammatory conditions, cirrhosis, or other liver diseases Weight loss > 2.5 kg in the last 6 months Being on pharmacological treatment of any kind Taking dietary supplements containing antioxidants other than vitamins Being a smoker or habitual alcohol consumer; being HIV positive Being pregnant or breastfeeding Blood pressure ≥ 140 mmHg (systolic) and ≥ 90 mmHg (diastolic) Total cholesterol ≥ 240 mg/dL, LDL cholesterol ≥ 160 mg/dL, or TG ≥ 200 mg/dl - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 40 Years - MaximumAge: 75 Years - StdAgeList: Adult, Older Adult