Alveolar-capillary Reserve After Exercise in Chronic Obstructive Pulmonary Disease (COPD) (COP-DTPA)
It is unknown whether individuals with COPD exhibit abnormal alveolar-capillary breaching during exercise, and whether this contributes to exertional dyspnoea. The aim of this study is to investigate whether individuals with COPD exhibit an abnormal increase in alveolar-capillary breaching during exertion, as indicated by an increase alveolar-capillary permeability with a concomitantly exacerbated increase in lung tissue mass.
- EligibilityCriteria: Inclusion criteria - individuals with COPD  Men and women 45-80 years old COPD (GOLD stage I to III) Resting arterial oxygenation > 90%  Inclusion criteria - healthy controls  Men and women 45-80 years old Non-smokers Normal lung function Same sex, age (± 3 years) as the COPD group  Exclusion criteria - individuals with COPD  Symptoms of ischemic heart disease Known heart failure Symptoms of illness, including fever, within 2 weeks prior to the study Pregnancy • Known renal or liver diseaseActive smoking (within 3 weeks)  Exclusion criteria - healthy controls  Known chronic lung disease Symptoms of ischemic heart disease Known heart failure Symptoms of illness, including fever, within 2 weeks prior to the study Pregnancy Known renal or liver disease Active smoking (within 3 weeks) - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 45 Years - MaximumAge: 80 Years - StdAgeList: Adult, Older Adult