Metreleptin in Anorexia Nervosa
The treatment of anorexia nervosa often proves to be difficult. There are no drugs that work specifically for the treatment of anorexia nervosa. Experimental administration of metreletpin (synthetically produced leptin) to patients with anorexia nervosa has produced positive results. This study tests the effect of metreleptin in comparison with placebo, which could potentially make treatment easier. The aim of the study is to investigate whether treatment with metreleptin can help to reduce the symptoms of anorexia nervosa and improve mood and weight.
- EligibilityCriteria: Inclusion Criteria:  Current diagnosis of AN according to DSM-5 (American Psychiatric Association [APA], 2013) diagnosed with SCID-5 (First et al., 2015) BMI > 13 kg/m2; BMI ≤ 17.5 kg/m2; body weight > 35 kg Hospitalisation in the Eating Disorders Unit, Department of Consultation-Liaison Psychiatry and Psychosomatic Medicine, University Hospital of Zurich Ability to understand German language- Age range: 18 - 40 years Depressive symptoms: HAMD-17 ≥ 8 Negative pregnancy test, non-lactating and double birth control Informed Consent as documented by signature  Exclusion Criteria:  Illicit drug intake within last month; current alcohol use disorder Severe psychiatric and/or severe somatic comorbidities; f. e. lifetime diagnosis of schizophrenia, bipolar disorder, inflammatory bowel disorders, diabetes mellitus, autoimmune disorders, pancreatitis, neurological disorders, cancer including lymphoma Acute suicidality or current serious non-suicidal self-injury - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 40 Years - StdAgeList: Adult