A Multicenter Prospective Clinical Cohort Study on the Pathogen Spectrum of Severe Hepatitis (Liver Failure) Complicated With Infection
The goal of this observational study is to expound the population and characteristics of pathogenic microorganisms with co-infection, draw the pedigree of pathogenic microorganisms, and evaluate its influence on disease outcome in patients with severe hepatitis (liver failure). The main questions it aims to answer are:

Mapping of infectious agents in patients with severe hepatitis (liver failure)
Constructing early warning predictive models to explore how to give an individualized regimen of integrated immune function.
- EligibilityCriteria: Inclusion Criteria:  Patients agreed to participate in the study and signed an informed consent form; Sex is not limited and age is 18-70 years old; HBsAg positive for more than 6 months, or hepatitis E IgM positive, or hepatitis E RNA positive; Progressive deepening of jaundice in a short period of time (serum total bilirubin greater than 10 times the upper limit of normal or rising ≥17.1 umol/L per day); Sgnificant bleeding tendency with PTA ≤ 40% and exclusion of other non-hepatic factors.  Exclusion Criteria:  Patients with severe hepatitis caused by other non-hepatophilic viral infections; Patients who were considered by the investigator to be unsuitable for participation in the study. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 70 Years - StdAgeList: Adult, Older Adult - StudyPopulation: Patients with severe viral hepatitis (liver failure) who met the inclusion and exclusion criteria and were hospitalized in the First Hospital Affiliated to Zhejiang University School of Medicine, Beijing Ditan Hospital Affiliated to Capital Medical University, Beijing You'an Hospital Affiliated to Capital Medical University, Huashan Hospital Affiliated to Fudan University, and Qilu Hospital of Shandong University. - SamplingMethod: Non-Probability Sample