Hybrid Closed-loop Insulin Delivery System in Perioperative Diabetic Patients: an Open-label, Randomized Controlled Trial
Perioperative management of glucose levels remains challenging. The purpose of the study is to compare the hybrid closed-loop insulin delivery system with the standard insulin therapy ( insulin pump with CGM, insulin dose controlled by physicians) in controlling glucose levels among patients in the perioperative period.
- EligibilityCriteria: Inclusion Criteria:  1）18~75 years old (including 18 years old and 75 years old),  2）Perioperative patients with need diabetes including type 2 diabetes mellitus and other special types of diabetes mellitus and need insulin therapy;  3）Fasting blood glucose ≥7.0mmol/L or random blood glucose 11.1≥mmol/L;  4）Patients signed the informed consent form and volunteered to participate in the clinical trial.  Exclusion Criteria:  The patients were complicated with diabetic emergencies, such as diabetic ketoacidosis, diabetic hyperosmolar non-ketotic coma, etc. Type 1 diabetes mellitus Patients with severe cardiac and renal organ dysfunction: cardiac function above grade III; Serum creatinine over 442μmol/L; Hemoglobin less than 90g/L; White blood cell count <4.0×109/L or platelet count <90×109/L; Patients had used glucocorticoids for more than 1 week or were currently using glucocorticoids within 1 month before screening Patients who are allergic to drugs specified in clinical protocols Patients who are not suitable for conventional insulin pump therapy. Patients who are allergic constitution and allergic to tape Patients with skin diseases such as rash and prurigo, or abnormal coagulation function; Patients who suffer from mental illness, have no self-control, and cannot express themselves clearly. Other circumstances that investigator considered to be inappropriate for clinical trial participation;  11) Patients with severe complications during or after surgery. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 75 Years - StdAgeList: Adult, Older Adult