A Study of the Association Between Frailty and Acute Postoperative Pain in Elderly Thoracoscopic Surgery Patients
To gain a clearer understanding of the association between frailty and postoperative acute pain in elderly thoracoscopic surgery patients and its underlying mechanisms, to provide new solution ideas to reduce the level of postoperative acute pain and improve the debilitating state of elderly thoracoscopic surgery patients, and consequently improve their quality of life and mental status.
- EligibilityCriteria: Inclusion Criteria:  patients undergoing thoracic surgery under general anesthesia with 48 h of postoperative patient-controlled analgesia; age ≥60 years; ASA class I-III; signed informed consent; patients undergoing thoracoscopic surgery.  Exclusion Criteria:  Patients who themselves refuse to participate in the study; Drug dependence; Patients who cannot cooperate with communication and have verbal communication difficulties; Patients who cannot assess frailty preoperatively and pain postoperatively; Failure to provide a compliant fecal sample at the agreed time; antibiotic treatment within the last month; intestinal dysfunction (e.g., irritable bowel syndrome, inflammatory bowel disease, chronic diarrhea, and other types of intestinal disorders); comorbidities of certain metabolic disorders (e.g., thyroid dysfunction, diabetes mellitus, and so on) that may affect the structure of the microbial community; - HealthyVolunteers: No - Gender: All - MinimumAge: 60 Years - StdAgeList: Adult, Older Adult - StudyPopulation: It is proposed to observe cases with age greater than or equal to 60 years undergoing thoracoscopic surgery at Tongji Hospital from February 2024 to October 2024 who meet the inclusion and exclusion criteria. - SamplingMethod: Non-Probability Sample