Endoscopic Sleeve Gastroplasty Technique Comparison for Weight Loss
The Investigators propose suture plication placement at the distal gastric body drives a significant portion of weight loss in endoscopic sleeve and sutures only need to be placed in the distal gastric body. Therefore, in this pilot study, the investigators aim to compare "belt" with "belt and suspenders" plication pattern using the Endomina system to determine percent total weight loss.
- EligibilityCriteria: Inclusion Criteria:  Patients with 18-65 years of age BMI ≥ 30 kg/m2 Capable of giving informed consent and available to return for follow-up visit  Exclusion Criteria:  Untreated H. pylori infection Active gastric or duodenal ulceration Malignant or premalignant gastric diseases (such as intestinal metaplasia, high grade dysplasia, gastric adenocarcinoma, or gastrointestinal stromal tumor (GIST)) Severe reflux esophagitis (Los Angeles Classification (LA) Grade C or D) Esophageal or gastric varices and/or portal hypertensive gastropathy Gastroparesis History of gastric surgery/endoscopic procedure Active psychological issues preventing participation in a lifestyle modification program Known history of endocrine disorders affecting weight (uncontrolled hypothyroidism) Severe coagulopathy Active smoking Substance abuse Serious health condition that increased risk of anesthesia and/or endoscopic procedure Pregnancy or lactation Patients who require Non-Steroidal Anti-inflammatory Drugs (NSAID) use - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 65 Years - StdAgeList: Adult, Older Adult