Analysing HIgh Dose Probiotic Peanut Oral Immunotherapy (PPOIT) and High Dose Peanut Oral Immunotherapy (OIT) Versus LOw Dose Peanut OIT for Peanut Allergy
This study will compare the effectiveness of three different treatments to treat peanut allergy
- EligibilityCriteria: Inclusion Criteria:  Aged 1-10 years. >7kg (the weight considered safe for the administration of an adrenaline injector); Confirmed diagnosis of peanut allergy as defined by a failed DBPCFC with peanut and a positive SPT or sIgE to peanut at screening; Has a legally acceptable representative capable of understanding the informed consent document and providing consent on the participant's behalf  Exclusion Criteria:  History of severe anaphylaxis (as defined by persistent hypotension, collapse, loss of consciousness, persistent hypoxia or ever needing more than three (3) doses of intramuscular adrenaline or an intravenous adrenaline infusion for management of an allergic reaction) Severe anaphylaxis during the study entry DBPCFC (defined as persistent hypotension, collapse, loss of consciousness, persistent hypoxia, or requiring more than 3 doses of intramuscular adrenaline or an intravenous adrenaline infusion for management of an allergic reaction) Ongoing chronic persistent asthma (as per Australian Asthma Foundation guidelines) Underlying medical conditions (e.g. cardiac disease) that increase the risks associated with anaphylaxis Use of beta-blockers, and angiotensin converting enzyme (ACE) inhibitors Reacting to the placebo component during the study entry DBPCFC Have received other food immunotherapy treatment in the preceding 12 months Currently taking immunomodulatory therapy (including allergen immunotherapy) Past or current major illness that in the opinion of the Site Investigator may affect the subject's ability to participate in the study e.g. increased risk to the participant History of suspected or biopsy-confirmed eosinophilic oesophagitis (EoE) Subjects who in the opinion of the Site Investigator are unable to follow the protocol Another family member already enrolled in the trial (to maintain blinding, safety and equity of access) or in any other clinical trial from the same study group. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 1 Year - MaximumAge: 10 Years - StdAgeList: Child