Cognitive Disorders in Hereditary Spastic Paraplegia Type 4
Hereditary spastic paraplegia type 4 is the most frequent mutation of hereditary spastic paraplegias. It is commonly described as pure, with progressive weakness of the lower limbs, pyramidal syndrome and vesico-sphincter disorders. However, cognitive disorders have been reported for over 20 years, but remain poorly characterized.
- EligibilityCriteria: Inclusion Criteria:  Patient over 18 years of age, living in the Grand Est region (France) Patient with a pathogenic or probably pathogenic variant (class 4 or 5) in the SPAST gene.  Exclusion Criteria:  dementia comorbidities or cognitive disorders unrelated to the pathology that may affect neuropsychological tests. - HealthyVolunteers: No - Gender: All - StdAgeList: Child, Adult, Older Adult - StudyPopulation: Patients followed in the Grand Est region for type 4 spastic paraplegia with identification of a pathogenic or probably pathogenic variant in the SPAST gene. - SamplingMethod: Non-Probability Sample