Immunogenicity and Safety of Inactivated and Live-attenuated HAV Vaccine Among Thai Healthy Children and Adolescents
Hepatitis A virus (HAV) vaccine is an effective strategy to prevent natural HAV infection. In Thailand, there are 2 types of HAV vaccine available, including inactivated HAV vaccine and live-attenuated HAV vaccine. This study aims to compare the immunogenicity and safety of inactivated and lived-attenuated HAV vaccine among Thai healthy children and adolescents age 18 months to 18 years.
- EligibilityCriteria: Inclusion Criteria:  Age between 18 months and 18 years Has healthy status Has no history of hepatitis A infection or previous hepatitis A disease Has never received hepatitis A vaccine (from vaccine booklet or parental history) Participants and/or caregivers gives written inform consent/assent form  Exclusion Criteria:  Has acute illness within 4 weeks before enrollment Has fever with jaundice within 4 weeks before enrollment Has underlying disease of thrombocytopenia, coagulopathy, hemophilia A or B, neurologic disease, immunocompromised condition, chronic liver disease, chronic hepatitis B or C infection Has received immunosuppressive agents or immunomodulatory agents, corticosteroid >2 mg/kg/day or 20 mg/day within 6 months before enrollment Has received blood or blood component, or intravenous immunoglobulin within 6 months before enrollment Has received any lived-attenuated vaccine within 30 days before enrollment Has history of severe allergy to vaccine or vaccine component, including aluminum hydroxide, 2-phenoxyethanol, neomycin, formaldehyde, gentamicin sulfate, or has history of anaphylaxis or severe allergic reactions following vaccination Women planning for pregnancy, pregnant women or lactating women Women in childbearing age who cannot use contraceptive methods during study participation Is concurrently involved in other clinical trials in which receiving an investigational vaccine or study drug as part of study participation Have any condition that, in the opinion of the site investigator, would compromise the subject's ability to participate in the study - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Months - MaximumAge: 18 Years - StdAgeList: Child, Adult