A Study to Test if Trevogrumab or Trevogrumab With Garetosmab When Taken With Semaglutide is Safe and How Well They Work in Adult Patients With Obesity for Weight Loss and Fat Loss
This study is researching experimental drugs called trevogrumab and garetosmab (called "study drugs") in combination with another drug, semaglutide (Wegovy®). Part A of the study, the sponsor is only researching trevogrumab. Part B of the study the sponsor is researching trevogrumab, garetosmab, and Wegovy either alone or in different combinations with each other. Part A of the study is focused on healthy participants. Part B of the study is focused on participants with obesity. The aim of Part A of the study is to see how safe and tolerable the study drug is in healthy participants. The aim of Part B of the study is to see how safe and effective the study drug is when combined with Wegovy.

Parts A and B of the study are looking at several other research questions, including:

What side effects may happen from taking the study drug
How much study drug is in the blood at different times
Whether the body makes antibodies against the study drug (which could make the drug less effective or could lead to side effects)
- EligibilityCriteria: Key Inclusion Criteria  Part A  Male or female participants age ≥18 to ≤55 years of age at the time of screening  BMI ≥18 and ≤32 kg/m2, at the screening visit  Part B  Male or female participants ≥18 to ≤80 years of age at the time of screening BMI ≥30 kg/m2 History of 1 or more self-reported unsuccessful dietary attempts to lose weight  Key Exclusion Criteria  History of diabetes (Type 2 or Type 1). History of gestational diabetes is permitted Previous bariatric surgery or planned bariatric surgery History of hypertrophic cardiomyopathy Abnormal electrocardiogram (ECG) findings at screening that meet Cornell voltage criteria for left ventricular hypertrophy Any malignancy in the past 5 years prior to screening (except for nonmelanoma skin cancer that has been resected with no evidence of metastatic disease for 3 years prior to screening) History of poorly controlled hypertension, as defined in the protocol Have a history of any other condition (such as known drug abuse, alcohol abuse, diagnosed eating disorder, or a severe mental illness) that, in the opinion of the investigator, may preclude the participant from following and completing the protocol Have history of use of marijuana/tetrahydrocannabinol (THC) within 3 months of enrollment and are unwilling to abstain from marijuana/THC use during the trial  Note: Other protocol-defined Inclusion/ Exclusion Criteria apply - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge: 80 Years - StdAgeList: Adult, Older Adult