Aneurysmal Subarachnoid Hemorrhage Treatment Based on Intracranial Pressure Monitoring
ASTIM is a multicenter, prospective, randomised, blinded end-point assessed trial, to investigate the efficacy and safety of treatment based on intracranial pressure monitoring in improving the prognosis of patients with aneurysmal subarachnoid hemorrhage.
- EligibilityCriteria: Inclusion Criteria:  The diagnosis of aSAH is established through the presence of SAH symptoms, confirmed by computed tomography (CT) scan or lumbar puncture, and further substantiated by cerebral angiography (CTA) or digital subtraction angiography (DSA) to identify the rupture of an intracranial aneurysm as the etiology. It is resolved to perform microsurgical clipping or endovascular therapy within 72 hours of the acute phase, along with the treatment of the ruptured aneurysm in phase I stage (excluding patients with exacerbated SAH due to intraoperative aneurysm rupture and occlusion of feeding arteries). Be aged 18 years or older; The onset of symptoms should occur within 72 hours; The GCS score should range from 6 to 12 points; Obtain the consent of the patient and their family members, and have them sign an informed consent form.  Exclusion Criteria:  Pregnancy or lactation period; Patients presenting with bilateral dilated pupils upon admission; Patients lacking spontaneous breathing or suffering from shock; Patients with concurrent tumors, hemorrhagic diseases, or other severe underlying conditions (such as chronic obstructive pulmonary disease, multiple organ dysfunction syndrome, severe diabetes mellitus, congestive heart failure, and chronic kidney disease); Patients with a history of brain disorders or previous brain surgeries; Hemorrhage attributable to causes other than aneurysm; Aneurysmal rupture bleeding concurrent with moyamoya disease; Other underlying conditions that impact prognosis; Patients volunteering for ICP monitoring; Participants in other ongoing clinical trails; Other circumstances deemed inappropriate for inclusion (to be determined by two physicians). - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult