From Fetal-maternal Interface Immune Tolerance to Endometrial Cancer Immune Escape: Potential Targets for Immunotherapy
Non-interventional retro-prospective study on Endometrial tissue samples taken from surgically treated patients.
- EligibilityCriteria: Inclusion Criteria:  Age >18 years; Histological diagnosis of endometrial hyperplasia with and without atypia, carcinoma of the endometrium histotype endometrioid at any stage of the disease (FIGO I-IV), patients subjected to hysterectomy for benign extra-endometrial pathology, patients with recurrence/metastasis from endometrioid endometrial carcinoma that are subjected to surgery; Adequate biological material to be able to carry out the analyzes previously described; Written informed consent (only for patients in the prospective part and/or in follow-up); For the retrospective part: availability of samples adequately stored at the Institute biobank and availability of follow-up data.  Exclusion Criteria:  Comorbidities not controlled with adequate medical therapy; Infections of the endometrial cavity (pyometra); Synchronous tumors; Neoadjuvant treatments; Previous radiation treatments on the pelvic region. - HealthyVolunteers: No - Gender: Female - GenderBased: Yes - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult - StudyPopulation: The population is represented by patients with endometrial cancer who have undergone, or who have will undergo surgery - SamplingMethod: Non-Probability Sample