Impact of Administration of Esmolol on Nociception Level-guided Control of Nociception.
This study aims to evaluate esmolol's perfusion impact during induction and maintenance of general anesthesia, using Nociception-Level-guided control of nociception, in adult patients undergoing laparoscopic and lower abdominal surgery, on intraoperative remifentanil consumption and postoperative pain in the Post-Anesthesia Care Unit.
- EligibilityCriteria: Inclusion Criteria:  Fully consented, American Society of Anesthesiologists Classification Score 1-3 patients from 18yo to 65yo Undergoing laparoscopic surgery associated with sub umbilical mini-laparotomy. Eligible surgeries will be hysterectomy (excluding vaginal approach) and left hemicolectomy, of duration time expected under 180 minutes, under general anesthesia No allergy to one of the medications used in this study  Exclusion Criteria:  Contraindication to the use of the study drug (esmolol) is an exclusion criterion :  Hypotension Sinus bradycardia Sick sinus syndrome Second and third degree A-V block Pulmonary hypertension Right ventricular failure secondary to pulmonary hypertension Decompensated heart failure Cardiogenic shock Nontreated pheochromocytoma Known hypersensitivity to esmolol or any of the inactive ingredients of the product Allergy to esmolol or other beta blockers (cross-sensitivity is possible) Renal dysfunction Airway disease such as asthma or chronic obstructive pulmonary disease Thyrotoxicosis Myasthenia gravis Raynaud's disease or peripheral circulatory disorder  Other situations leading to exclusion :  Severe mental impairment Chronic use of opioids, β-adrenergic receptors antagonists High risk of conversion to laparotomy according to the surgical team (>25%)  Patients will automatically be excluded after recruitment if they withdraw their consent, or if laparoscopy is converted to laparotomy. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 65 Years - StdAgeList: Adult, Older Adult