Cohort Multiple Randomized Controlled Trial in Pediatric Asthma
The overarching goal of this study is to optimize pediatric asthma care and to continuously evaluate variations/innovations of the care (including transformation to remote eHealth care).

Primary Objectives within cmRCT cohort:

Provide a framework for multiple randomized (eHealth) interventions for asthmatic children
Generate short- and long-term data on Quality of life (QoL), asthma outcomes (asthma control, lung function), quality of care, self-management capacity, healthcare use, and therapy compliance in a representative secondary care pediatric asthma cohort.

Secondary Objectives within cmRCT cohort:

Evaluate current pediatric asthma care at the Pediatric department of Medisch Spectrum Twente, in order to explore possible improvements for the pediatric asthma care.
Compare the short and long-term asthma outcomes between the eHealth care path and the outpatient care path.
Compose patient risk profiles that include both personal, clinical and exposome markers and clinical asthma endpoints (for example clinical admission/exacerbations).
- EligibilityCriteria: Inclusion Criteria:  Is 4 to 18 years old Is patient at the children's department at Medisch Spectrum Twente at moment of inclusion  Is diagnosed with asthma by a pediatrician following the Global Initiative for Asthma(GINA) guidelines 2022 [8]:  *Medical history fitting asthma diagnosis:  Based on (typical) symptoms: (nighttime) wheezing, dyspnea, coughing (triggered by either viral infections, exercise, allergens or weather changes) (Possibly) supplemented with a family history/atopy  AND  *Spirometry variable expiratory airflow limitation by at least one of these criteria:  FEV1/FVC reduced compared to lower limit of normal(Z-score ≤ -1.64) Positive bronchodilator responsiveness(increase FEV1>12%) Positive Exercise Challenge Test (ECT)(decrease FEV1≥ 13%) Excessive variation in lung function (LF) between tests from different dates (variation FEV1>12% pred)  Exclusion Criteria:  The child and/or parent(s) has/have insufficient command of the Dutch language resulting in the insufficient ability to understand and/or answer questions - HealthyVolunteers: No - Gender: All - MinimumAge: 4 Years - MaximumAge: 18 Years - StdAgeList: Child, Adult