Pancreatic Cancer Detection Consortium (PCDC) Prospective Cohorts
This study evaluates individuals without pancreatic cancer, but who have been determined to be at higher-than-average lifetime risk of developing pancreatic cancer to help detect pancreatic cancer or other cancers at an earlier time when they might be more easily treated and cured.
- EligibilityCriteria: Inclusion Criteria:  PDAC FAMILY HISTORY OR PDAC RELATED GENETIC MUTATIONS:  Age: 50 or older, plus at least one of the following:  Mutation unknown or absent:  2+ relatives with PDAC on same side of family where 2 affected are first degree related to each other and at least 1 affected is first degree related to subject; OR 2+ affected first degree relatives (FDR), defined as blood related parents, siblings, or children)  Known pathogenic/likely pathogenic (P/LP) mutation in at least one of the following:  CDKN2A/p16, PJS (STK11), Hereditary pancreatitis with confirmed protease serine 1 (PRSS1)  OR 1+FDR or second degree relative (SDR) with PDAC and a known P/LP mutation in one or more of:  ATM, BRCA1, BRCA2, PALB2, Lynch syndrome (MLH1, MSH2, MSH6, PMS2, EPCAM), TP53  HIGH-RISK OR WORRISOME PANCREATIC CYSTS:  18 years of age or greater and meeting Fukuoka worrisome (FW) or Fukuoka high-risk (FHR) criteria  High risk stigmata:  Obstructive Jaundice in a patient with cystic lesion of the head of the pancreas Enhancing mural nodule ≥ 5 mm Main pancreatic duct ≥ 10 mm  Worrisome features:  Presence of pancreatic duct stricture, defined as focal pancreatic duct narrowing with upstream duct => 6 mm Cyst ≥ 3 cm Enhancing mural nodule < 5 mm Thickened/Enhancing cyst wall Main duct size 5-9 mm Pancreatitis Lymphadenopathy Increased CA 19-9 Cyst growth rate ≥ 5 mm /2 years  Exclusion Criteria:  * Is unable to provide informed consent  Has received a non-autologous bone marrow transplant or has an active hematologic malignancy (i.e., leukemia or lymphoma) Current or prior history of PDAC or total pancreatectomy Is currently a prison inmate Is not able to speak or read English - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult - StudyPopulation: Patients with pancreatic ductal adenocarcinoma (PDAC) family history, PDAC related genetic mutations or high risk or worrisome pancreatic cysts - SamplingMethod: Non-Probability Sample