Aurora Test for ART Donor Patients (AURORA-Donor)
This is a randomized observational study. The main aim is to determine potential oocyte competence predictive mRNA expression profiles in the cumulus cells isolated form individual oocytes. In 2 patient cohorts: 1)GnRH Antagonist & hr-FSH with GnRH Agonist trigger, 2) Progesterone & hr-FSH with GnRH Agonist trigger.
- EligibilityCriteria: Inclusion Criteria Donor:  Patients are 18 to 35 years old BMI between 17-30 Regular menstrual cycles AFC > 8 Patient profile in compliance with SEF (Sociedad Española de Fertilidad) directives for egg donation (medical, psychological and genetic screening, informed consent) Patients' stimulation: GnRH Antagonist & hr-FSH with GnRH Agonist trigger or Progesterone & hr-FSH with GnRH Agonist trigger Patients agree that the oocytes will be denuded for cumulus testing and provide written informed consent for participation to the study  Exclusion Criteria Donor:  BMI < 17 or > 30 Extreme irregular menstrual cycles (<20 days or >40 days) AFC < 8 <8 MII on previous egg retrieval Women with history of poor oocyte maturation or known maturation defect or unexplained failure in previous treatments Patients that fail to comply with SEF (Sociedad Española de Fertilidad) directives for egg donation (medical, psychological and genetic screening, informed consent)  Inclusion Criteria Recipient:  Patients applying for ART egg donation with fresh/frozen sperm from the partner or frozen donor sperm. With eSB-FET in modified natural cycle or an HRT cycle. Patients are from 18 to 50 years old. Patients will be treated by ICSI (intracytoplasmic sperm injection) and eSB-FET (elective Single Blastocyst Frozen Embryo Transfer) Recipient patients agree that the donors' oocytes will be denuded for cumulus testing and provide written informed consent for participation to the study  Exclusion Criteria for oocyte Recipients  Patient included in any other prospective study. BMI < 17 or > 35 Severe uterine factor: Multiple myomectomy, multiple fibroids, major uterine malformation (unicorn, septum), Asherman Sd, severe adenomyosis Repeated Implantation Failure or Repeated Pregnancy Loss after euploid Single Blastocyst Transfer Severe male factor: Abnormal Caryotype or FISH, severe OAT / Cripto-Azoospermia, DNA Fragmentation >50% after medical treatment TESE / TESA (testicular sperm extraction/aspiration) - HealthyVolunteers: Accepts Healthy Volunteers - Gender: Female - MinimumAge: 18 Years - MaximumAge: 35 Years - StdAgeList: Adult - StudyPopulation: Donor's for this study must be between 18 and 35 years of age, and compliant with SEF directive for egg donation. Only patient with at least 6 MII will be included in the study. - SamplingMethod: Non-Probability Sample