Accelerated Theta Burst Stimulation for Treatment of Suicidality in Depressed Patients
The objective of this study is to investigate efficacy of accelerated theta burst stimulation (TBS) in suicidal reduction in patients with unipolar and bipolar depression
- EligibilityCriteria: Inclusion Criteria:  Diagnosis of Major depressive episode as a part of MDD or bipolar (I or II) disorder and confirmed by Structured Clinical Interview for DSM-IV-TR Axis I Disorders (SCID-I). (First & Gibbon.,2004 ). Meeting the severe depression cutoff for MADRS (>/=35) at baseline visit. Meeting the severe depression cutoff for BDI-II (>/=30) at baseline visit. Presence of suicidal ideation and/or behavior (confirmed with Columbia Scale for the Rating of Suicide Severity (C-SSRS) Adults (Age 19 years or older ) Right handedness Both genders Able to provide informed consent to participate in the study Participants were required to have been taking a stable pharmacological regimen for 2 weeks before screening. Pass the TMS adult safety screening (TASS) questionnaire  Exclusion Criteria  Current substance use disorder during the past 3 months Current psychotic disorder or symptoms Presence of dementia Presence of major medical illness, for example metastatic cancer, end stage renal disease Inability to verify contact information. Presence of any clinically significant neurological disorder, including organic brain disease, epilepsy, stroke, brain lesions, previous neurosurgery, or personal history of head trauma that resulted in loss of consciousness for > 5 minutes and retrograde amnesia for > 30 minutes Conductive, ferromagnetic or other magnetic sensitive metals that are implanted or are non-removable within 30 cm treatment coil (around the head) Presence of hypomanic symptoms (score on Young Mania Rating Scale (YMRS) greater than 12) Current severe insomnia (must sleep a minimum of 5 hours the night before stimulation) Using lorazepam greater than 2 mg daily (or equivalent) due to the potential to limit rTMS efficacy - HealthyVolunteers: No - Gender: All - MinimumAge: 19 Years - StdAgeList: Adult, Older Adult