Endotypic Stability in CRS
A Case control study with 150 cases and 50 controls will be conducted. Immunologic (cytokines measurements in nasal secretions and sinonasal tissues), histopathologic (tissue eosinophilia) and clinical parameters (Lund-Mackay and Lund-Kennedy score, lung function tests), surveys (SNOT- 22, SF-36 quality of life survey) will be compared between different groups of patients
- EligibilityCriteria: Inclusion Criteria:  Patients with Chronic sinusitis (with or without polyps) Undergoing endoscopic sinus surgery during the study period More than 18 years No chronic illness/ malignancy - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 100 Years - StdAgeList: Adult, Older Adult - StudyPopulation: Patients with Chronic sinusitis (with or without polyps) undergoing endoscopic sinus surgery. - SamplingMethod: Non-Probability Sample