Green Propolis Extract and Royal Jelly in Hypertensive Patients and/or With Chronic Kidney Disease
This work aims to evaluate the effects of the association of green propolis extract with royal jelly on inflammation and oxidative stress in participants with CKD and SAH, in a longitudinal, randomized, double-blind, placebo-controlled clinical trial that will be carried out for 2 months.
- EligibilityCriteria: Inclusion Criteria:  Conservative group: stages 3 and 5 of CKD (GFR from 15 to 59 mL/min), receiving nutritional treatment at the Ambulatório de Nutrição Renal - UFF for at least 6 months, following individual dietary prescription (with energy supply of 25-35kcal/kg/day and 0.6g/kg/day protein, as recommended for this treatment - NKF-KDOQI, 2020). Hemodialysis group: on regular HD treatment for at least 6 months, who have a fistula arteriovenous artery (AVF) as vascular access and who are following a dietary prescription individualized (with energy supply of 25-35kcal/kg/day and protein of 1.0 - 1.2 g/kg/day, as recommended for this treatment - NKF-KDOQI, 2020). SAH group: using one to three antihypertensive drugs, being monitored regularly in the outpatient clinic for more than 6 months, and without the need for changes in the doses of medications in the last 3 months  Exclusion Criteria:  Participants with autoimmune and infectious diseases, diabetes, cancer, and AIDS will be excluded; pregnant women; those using catabolic drugs or antibiotics; with catheter access to hemodialysis; use of antioxidant vitamin supplements, prebiotics, probiotics, symbiotics, regular intake of propolis, and who are allergic to corn starch or report being allergic to bee stings. Participants with acute myocardial infarction (AMI) and/or cerebrovascular accident (CVA) in the last 6 months will also be excluded; with SAH stages 2 or 3 according to the Brazilian hypertension guideline. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 75 Years - StdAgeList: Adult, Older Adult