Acute Effects of Legume-enriched Meals Compared to Western Diet Meals on Postprandial Metabolism in Participants With Increased Cardiometabolic Risk
The aim of the study is to investigate the postprandial effects of legume-enriched meals compared to Western Diet meals on postprandial metabolism. In this context, older adults with increased risk for cardiometabolic diseases consume 4 mixed meals with 36 g or 62 g of protein either designed according to the Planetary Health Diet with legumes as primary protein source or the Western Diet with animal foods as primary protein source, in a randomized order. In a postprandial observation period of 6 hours, parameters of lipid metabolism, glucose and insulin metabolism, amino acid profile, as well as markers of inflammation and vascular function are analysed. Furthermore, neuropsychological parameters and satiety-associated hormones are investigated.
- EligibilityCriteria: Inclusion Criteria:  written informed consent Non-smoking BMI: 27 - 34,9 kg/m2 Waist circumference (women ≥ 80 cm, men ≥ 94 cm) At least two of the following criteria of metabolic syndrome: Fasting triglycerides in serum: ≥ 150 mg/dL Fasting HDL-Cholesterol in serum: women < 50 mg/dl, men < 40 mg/dL Systolic blood pressure: ≥ 120 mmHg, diastolic blood pressure: ≥ 80 mmHg Fasting glucose in plasma: ≥ 100 mg/dL  Exclusion Criteria:  food intolerances and allergies (especially to legumes) Smoking malabsorption syndromes thyroid diseases impaired renal function chronic liver disease heart failure myocardial infarction insulin-dependent diabetes mellitus chronic inflammatory diseases tumors anemia immunosuppression intake of supplements (e.g., fish oil) Participation in another study other exclusion criteria at the discretion of the physician/ investigator - HealthyVolunteers: No - Gender: All - MinimumAge: 50 Years - MaximumAge: 75 Years - StdAgeList: Adult, Older Adult