A Comprehensive Evaluation of Tobacco-Flavored vs. Non-Tobacco Flavored E-cigarettes on Smoking Behavior
This clinical trial compares the use of tobacco flavored electronic cigarettes (ECs) to non-tobacco flavored ECs on smoking behavior in current cigarette smokers to use of nicotine replacement therapy (patches and lozenges). ECs may reduce cigarette craving and withdrawal symptoms, increase motivation and confidence to stop cigarette smoking, and decrease cigarette smoking and dependence. By comparing participants' preferred flavor ECs (PEC) to tobacco flavor ECs (TEC) to NRT, researchers hope to determine the effect of EC flavors on appeal and use, and learn how ECs affect smoking behaviors and health.
- EligibilityCriteria: Inclusion Criteria:  >= 21 years old Smoke >= 5 cigarettes per day for the past year Willing to use either an EC or NRT Read and speak English Have a smartphone  Exclusion Criteria:  Report currently using smoking cessation medications, NRT, or actively seeking treatment for smoking cessation Current use of an EC > 4 days a month Diagnosed medical conditions of lung disease, asthma, cystic fibrosis, heart disease or chronic obstructive pulmonary disease (COPD) Unmanaged (unmedicated and/or without counseling) diagnosis of schizophrenia History of cardiac event or distress within the past 3 months Currently pregnant, planning to become pregnant within 6 months, or breastfeeding High blood pressure not controlled by medications Serious angina pectoris or chest pain Stroke within the past three months Known allergy to propylene glycol or vegetable glycerin - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 21 Years - StdAgeList: Adult, Older Adult