Dial-Bicarb Trial: Effects of a Lower vs. Higher Concentration of Dialysate Bicarbonate
This is a pragmatic, two-arm, parallel-group, open-label, individual-randomized, superiority trial that will be conducted in hemodialysis units across Ontario. Patients at each dialysis unit will be randomly allocated into one of two study arms in a 1:1 ratio to receive a dialysate bicarbonate concentration of either 32 or 38 mmol/L. The intervention will be embedded into routine care and delivered by hemodialysis unit personnel.
- EligibilityCriteria: Inclusion Criteria:  - Patients at participating dialysis units who have received hemodialysis for at least 90 days  Exclusion Criteria:  Patients on in-centre nocturnal hemodialysis or in-centre frequent (greater than four times weekly) hemodialysis - HealthyVolunteers: No - Gender: All - StdAgeList: Child, Adult, Older Adult