Vaginal Fluid Collection for Detection of Endometrial Cancer
The primary objective of this study is to obtain de-identified vaginal fluid specimens from participants with an endometrial tissue biopsy-based histopathological diagnosis of endometrial cancer (EC), endometrial hyperplasia (AEH) with atypia or endometrial intraepithelial neoplasia (EIN).

The samples will be used for the purpose of research and development of a new molecular diagnostic test for the detection of EC, AEH and EIN.
- EligibilityCriteria: Inclusion Criteria:  Women ≥18 years of age. Women with endometrial tissue biopsy-based histopathological diagnosis of EC (any histology, including uterine carcinosarcoma), AEH or EIN. Women whose planned surgical intervention (if any) includes hysterectomy, D&C, or hysteroscopic resection.  Participant understands the study procedures and can provide informed consent to participate in the study and authorization for release of relevant protected health information to the study Investigator.  -  Exclusion Criteria:  Patient with recurrent and/or previously treated EC. Receipt of preoperative neoadjuvant chemotherapy or radiotherapy for current EC diagnosis prior to study enrollment. Prior hysterectomy. Current known pregnancy diagnosis. Prior or current biopsy and histopathology-proven cervical cancer. The presence of concomitant biopsy and histopathology-proven cervical dysplasia. Any prior pelvic or vaginal radiotherapy. Any current or prior cancer diagnosis (except basal cell or squamous cell skin cancer, non-gyn) within the past 5 years. Chemotherapy within the past 5 years. Prior intervention to treat, or surgery with intent to completely remove, the target pathology for the current diagnosis during the current episode. - HealthyVolunteers: No - Gender: Female - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult - StudyPopulation: The study will enroll women ≥18 years of age with an endometrial tissue biopsy-based histopathological diagnosis of endometrial cancer (EC), endometrial hyperplasia (AEH) with atypia, or endometrial intraepithelial neoplasia (EIN) presenting for management of their endometrial pathology. - SamplingMethod: Probability Sample