Predicting Cognition After DBS for Parkinson's Disease 2
The aim of the study is to improve estimation of cognitive outcome after STN-DBS in PD in order to avoid risk factors by optimizing peri- and intraoperative management personalize therapeutic strategies for optimal long-term benefit.

The investigators will test possible predictors (clinical, neuropsychological, neuroimaging, electrophysiological and molecular) for the risk of cognitive dysfunction after deep brain stimulation of the subthalamic nucleus (STN-DBS) in Parkinson's disease (PD) at a single center (Charité - Universitätsmedizin Berlin, Germany). Data collection takes place prior to as well as 3, 12 and 60 months after the STN-DBS operation. Participation is proposed to all PD patients that are planned to undergo STN-DBS after careful examination of eligibility for this treatment according to standard operation procedures.
- EligibilityCriteria: Inclusion Criteria:  Diagnosis of idiopathic Parkinson's Disease Indication for STN-DBS  Exclusion Criteria:  Internistic, surgical or psychiatric contrainidications with respect to the DBS operation or treatment for the STN-DBS group Dementia Relevant language barrier - HealthyVolunteers: No - Gender: All - GenderBased: Yes - MinimumAge: 18 Years - MaximumAge: 80 Years - StdAgeList: Adult, Older Adult - StudyPopulation: PD patients that are planned to undergo STN-DBS. - SamplingMethod: Non-Probability Sample