Hypophysectomy by Stereotactic Radiosurgery for Cancer-Related Pain
To learn if hypophysectomy (treatment of the pituitary gland) using a type of radiation treatment called stereotactic radiosurgery (SRS) can help to relieve cancer-related pain.
- EligibilityCriteria: Inclusion Criteria:  Age ≥ 18 years old on the day of signing informed consent and willing and able to sign a written informed consent. English fluency in order to complete PROs and neurocognitive assessment Pathologic or cytologic confirmation of malignancy. Poorly controlled intractable nociceptive or mixed pain limiting function or quality of life. Participants must have exhausted or not a candidate for standard of care pain control measures such as opioids, injections/ablations, conventional radiation therapy, or surgical intervention with a curative intent and pain limiting function that affects the participants quality of life in the judgment of the treating physician. Refractory status will require at least consultation and two follow-up visits with pain specialists (pain management or supportive care). ECOG performance status of 0-3. Life expectancy is greater than 4 weeks and less than 1 year in the treating physician's judgment.  Exclusion Criteria:  Participants with prior cranial or head/neck radiation where cumulative organ-at-risk dose constraints cannot be achieved (see section 4.2). Inability to have an MRI of the brain for reasons such as a non-compatible bioimplant that could be displaced during MRI, shrapnel embedded (such as from war wounds), metal workers, and machinists (potential for metallic fragments in or near the eyes). Expressions of pain due to depression, delirium or addictive behavior Participants who are pregnant. Known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the study in the judgment of the Investigators. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult