The Relationship Between Social Memory Disorders and Sleep Spindles in Children With Autism Spectrum Disorder
Research background and project basis

Autism spectrum disorder (ASD) is a lifelong neurodevelopmental disorder characterized by social disorders and repetitive stereotypical behavior. Social memory impairment is a significant feature of ASD patients, and the specific pathogenesis of social memory impairment in ASD patients is currently unclear, and there are no objective indicators to measure social memory levels. Sleep spindle wave is a special brain wave in sleep that is closely related to memory consolidation. However, no one has yet studied the impact of sleep spindles on social memory.

Research purpose

Exploring the correlation between sleep spindles and social memory in the population, providing reference for the auxiliary diagnosis of social memory disorders in children with ASD.
- EligibilityCriteria: Inclusion Criteria:  Children with ASD diagnosed through DSM-V (Healthy controls do not have this requirement) IQ score ≥ 75（WISC-IV，Wechsler Intelligence Scale for Children） Age: 6-18 Not receiving psychotropic medication (Or stopping medication for at least 2 weeks before the experiment)  Exclusion Criteria:  In addition to ASD, other mental illnesses are also combined Presence of a sleep disorder, sleep apnea, periodic leg movements during sleep, or atypical EEG patterns Left handed - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 6 Years - MaximumAge: 18 Years - StdAgeList: Child, Adult - StudyPopulation: It is expected to recruit 60 participants aged 6-18, of which 30 in the case group are all inpatient and outpatient cases from Xi'an Traditional Chinese Medicine Brain Disease Hospital, and are designated as ASD according to unified diagnostic standards; The healthy control group consists of 30 individuals from nearby community kindergartens and primary schools at Xi'an Traditional Chinese Medicine Brain Disease Hospital, who have not suffered from ASD or other diseases related to ASD research factors. - SamplingMethod: Non-Probability Sample