Collagen-targeted Positron Emission Tomography (PET) Imaging for Assessment of EGCG Effect
The primary purpose of this substudy is to determine if collagen-targeted PET using the type 1 collagen-targeted PET probe, Gallium-68 (68Ga)-labeled collagen binding probe 8 (CBP8) can inform as to drug effect of EGCG and assist in dose selection.
- EligibilityCriteria: Inclusion Criteria:  Enrolled in and eligible (based on screening procedures - Visit 1) for the main EGCG Phase 1 study, "Dose ranging study of oral epigallocatechin-3-gallate (EGCG) given daily for 12 weeks to patients with Idiopathic Pulmonary Fibrosis (IPF) evaluating safety, PK interactions with standard of care drugs, and biomarkers of drug effect Signed informed consent  Exclusion Criteria:  Pregnant or breastfeeding (a negative quantitative serum human chorionic gonadotropin (hCG) pregnancy test is required for females having child-bearing potential before the participant can participate)* Research-related radiation exposure exceeds 50 millisievert (mSv) in the prior 12 months Determined by the investigator to be clinically unsuitable for the study  Additional exclusion criteria for participants undergoing PET-MRI:  Electrical implants such as cardiac pacemaker, defibrillator, or perfusion pump Metallic or electric implants contraindicated for magnetic resonance-PET (MR-PET) scanning Claustrophobic reactions Estimated glomerular filtration rate (eGFR) of less than 30 mL/min/1.73 m2 within the prior 30 days  Known allergy to gadolinium  Women of childbearing potential (WCBP) are defined as a sexually mature woman not surgically sterilized or not post-menopausal for at least 24 consecutive months if < 55 years or 12 months if ≥ 55 years. - HealthyVolunteers: No - Gender: All - MinimumAge: 40 Years - MaximumAge: 85 Years - StdAgeList: Adult, Older Adult