The Effect of Three Different Medications on Anesthetic Success and Postoperative Pain
Pain is a very important factor in Endodontic treatment, Both intra- and Post-operatively. In case of symptomatic Irreversible pulpitis, a build up of inflammatory mediators makes it very difficult for the operator to reach the desired level of anesthesia in order to deliver a pain free treatment as well as to eliminate or at least reduce post-operative pain incidence and severity. therefore, a number of pre- medications was suggested with variable success rates. Therefore this trial aims at the use of a new category of anti-inflammatory medications which would be less harmful than the standard NSAIDs or steroids.
- EligibilityCriteria: Inclusion Criteria:  Patients with symptomatic irreversible pulpitis. Patients with active pain (moderate-to-severe) in mandibular molars. Males and females. Patient with the ability to understand and use pain scales. Patient who accepts to enroll to the study  Exclusion Criteria:  Patients' allergies or any other contraindication to any of the used medications or mepivacaine. Pregnant and lactating females. Patients have been taking pain medication 12 hours earlier. Patient has more than one symptomatic mandibular tooth in the same quadrant. Patients with periradicular pathosis and/or radiolucency other than widened periodontal ligaments. Patients with contributory medical history (ASA>II). - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult