Tapentadol vs Tramadol in Total Knee Arthroplasty
Compare the effectiveness of tapentadol and tramadol as part of a multimodal analgesia treatment for Total Knee Replacement (TKR).
- EligibilityCriteria: Inclusion Criteria:  Patients for elective TKR ASA PS I - III  Exclusion Criteria:  Patient refusal Cognitive disfunction Severe psychiatric disease Under medication with MAO inhibitors, tricyclic antidepressants, serotonin reuptake inhibitors Not speaking Greek Known allergy to the study drugs Contraindications for any of the study drugs Chronic renal failure (GFR < 50 ml/h) Liver failure Known regular use or misuse of opioids Pregnant women Patients undergoing general anesthesia - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 80 Years - StdAgeList: Adult, Older Adult