Establishment of Human Lung Stem Cell Proliferation System and Organoid Construction in COPD
The goal of this study is to proliferate human lung stem cell in vitro in order to establish a lung organoid derived from patients with COPD. The main question it aims to answer are:

Can human lung stem cell proliferate in vitro.
Can a lung organoid derived from patients with COPD be established. Participants will be sampled during pulmonary bronchoscope for organoid establishment.
- EligibilityCriteria: Inclusion Criteria:  1. Age under 55, regardless of gender 2. Patients with COPD lung disease who are going to undergo bronchoscopic biopsy 3. No genetic diseases and other respiratory diseases  Exclusion Criteria:  Other conditions determined by the investigators to be unsuitable for inclusion, such as difficult sampling, difficult follow-up, and complicated with other serious diseases - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 55 Years - StdAgeList: Adult - StudyPopulation: COPD Patients with indications of bronchoscopic biopsy - SamplingMethod: Non-Probability Sample