Predictors of Post-COVID Clinical and Cognitive Consequences
The CDC describes Post-acute sequalae of SARS-COV-2 infection (PASC) for the wide range of physical and mental health consequences experienced by some patients. These sequelae may be present four or more weeks after SARS-COV-2 infection, including patients who had initial mild or asymptomatic acute infection. However, there is complete absence of data whether chronic sleep changes due to COVID-19 infection may influence these physical and mental health consequences. While fatigue is one of the common post-COVID conditions, there are no systematic examinations of sleep disturbances in COVID-19 survivors. This will be a pilot observational retrospective and prospective cohort study, to systematically assess if sleep disturbances and severity of sleep apnea comprise a modifiable facet of PASC as well as the short-term and longer-term effects of COVID-19 infection itself on sleep, cognitive function, exercise capacity and lung function.
- EligibilityCriteria: Inclusion Criteria:  All individuals 18 years or older, with prior history of COVID-19 infection diagnosis Both genders including all racial and ethnic groups Patients with OSA (apnea hyponea index ≥ of 5/hour on polysomnography) with history of COVID-19 infection will be eligible with prior history of COVID-19 infection and without Covid-19 for Aim 2.  Exclusion Criteria:  Inability to give consent Active suicidal symptoms Children of all ages Pregnant women - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult - StudyPopulation: We will include all individuals 18 years or older, both genders, all racial and ethnic groups, with diagnosis of COVID-19 infection, diagnosed using any validated antigen detection test and/or polymerase chain reaction (PCR) test and of any severity level of COVID. Eligible patients with COVID-19 history of infection should be at least 1 month after the diagnosis of COVID-19 and should have been discharged to home if admitted to an acute care facility. COVID-19 antigen test positive patients who were completely asymptomatic at the time of COVID positive testing will be excluded. Controls will be patients without history of COVID-19 infection and age 18 years or older. In addition, patients with OSA (apnea hypopnea index ≥of 5/hour on polysomnography) with history of COVID-19 infection will be eligible for Aim 2. - SamplingMethod: Non-Probability Sample