Postoperative Intraperitoneal Pain Management Following Laparoscopic Cholecystectomy
Postoperative pain management is essential and the inability to treat acute pain appropriately in the first 48 postoperative hours represents a risk factor for developing chronic pain. No. study has investigated IP granisetron as an adjuvant to standard care for postoperative pain management in patients undergoing LC.
- EligibilityCriteria: Inclusion Criteria:  Patients who are scheduled to undergo elective LC. Adults (males and/or females) between the ages of 18-70 years old.  Exclusion Criteria:  Chronic pain other than cholelithiasis. Patients who received analgesics or sedatives 24 h before scheduled surgery. Severe hepatic (Child Pugh Class B and C) and renal dysfunction (CrCl <30ml/min) Previous allergic response to vortioxetine, and granisetron. Pregnancy and lactation Patients with communication problems, cognitive dysfunction, or psychological disorders Daily corticosteroid use - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 70 Years - StdAgeList: Adult, Older Adult