The Role of Immune Checkpoints in Lung Transplant (ILTRA)
The goal of this observational study is to learn about rejection in lung transplantation.

The main question it aims to answer is:

• what is the role of immune checkpoints in lung transplantation? Participants will describe pathways of rejection in lung transplantation analyzing the immune checkpoints on explanted lungs as well as trans-bronchial biopsies.
- EligibilityCriteria: Inclusion Criteria:  Lung transplant patients  Exclusion Criteria:  Hyperimmunized patients History of auto-immune disorders - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 70 Years - StdAgeList: Adult, Older Adult - StudyPopulation: Cohort 1: Participants who received lung re-transplantation for chronic lung allograft dysfunction.  Cohort 2 and 3: Participants who received first lung transplantation for end stage respiratory insufficiency. - SamplingMethod: Non-Probability Sample