Prophylactic Endobronchial Tranexamic Acid to Reduce Bleeding in Transbronchial Cryobiopsy
Transbronchial cryobiopsies are common procedures used to obtain tissue samples from airways for diagnostic purposes. While these procedures are safe, there is a risk of bleeding from the biopsy site. We are conducting a research study to assess the safety and effectiveness of using tranexamic acid prior to undergoing a transbronchial cryobiopsy.
- EligibilityCriteria: Inclusion Criteria:  Age ≥18 Signed informed consent Receiving a transbronchial cryobiopsy  Exclusion Criteria:  Age below 18 Pregnancy Bleeding diathesis (INR >1.5 or known hematological problems) Subarachnoid hemorrhage Any active bleeding (any site) Decompensated liver disease Active intravascular clotting Prior VTE On oral contraceptive therapy Platelet count less than 50,000 Use of antiplatelet medication other than low-dose aspirin within 5 days of procedure Use of therapeutic anticoagulation within the last 24 hrs Known severe pulmonary hypertension (pulmonary artery systolic pressure > 60 mmHg) Chronic renal failure (estimated GFR below 30 mL/min) Allergy or hypersensitivity to tranexamic acid or any of its ingredients Prisoners Comfort care planned or initiated within 72 hours of admission - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult