A Study of MK-8527 in Participants With Moderate and Severe Renal Impairment (MK-8527-008)
The goal of this study is to evaluate the effect of moderate and severe renal impairment (RI) on the pharmacokinetics (PK), safety, and tolerability of MK-8527. There will be no hypothesis testing in the study.
- EligibilityCriteria: Inclusion Criteria:  The main inclusion criteria include but are not limited to the following:  Moderate and Severe RI  With the exception of RI, is in sufficient health for study participation. Has stable renal function.  Healthy  Matches mean age to participants with moderate and severe RI. Has normal renal function.  Exclusion Criteria:  The main exclusion criteria include but are not limited to the following:  All participants  History of cancer (malignancy). Positive test results for Human-immunodeficiency virus (HIV), Hepatitis B surface antigen (HBsAg), or Hepatitis C virus (HCV). Had a major surgery or lost significant volume of blood within 56 days prior to dosing. Donated plasma within 7 days prior to dosing.  Moderate and Severe RI  Failed renal transplant or had a nephrectomy. End stage renal disease requiring dialysis. Any significant arrhythmia or conduction abnormality. Has non-sustained or sustained ventricular tachycardia. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge: 75 Years - StdAgeList: Adult, Older Adult