Positron Emission Mammography and Liquid Biopsy in Women With High-risk Breast Screenings
The goal of this pilot research study is to compare two experimental tests, namely Liquid Biopsy and Positron Emission Mammography (PEM) in women at high risk of breast cancer. The plan for this study is to evaluate if findings from Liquid Biopsy can be matched to images obtained by PEM.

Liquid Biopsy is a blood test that can detect early tumours in patients with malignancies, while PEM is an imaging tool equipped with a high-resolution camera that uses an injected positron emitting isotope to locate breast tumours. Participation in this study entails a blood draw for Liquid Biopsy test and a PEM imaging exam before undergoing a magnetic resonance imaging (MRI) - guided biopsy for a suspicious breast lesion.

If correlations between paired samples are observed between imaging using PEM and the Liquid Biopsy data, further studies will be conducted to evaluate if these techniques can help refine screening investigations and ultimately reduce the unnecessary biopsies and anxiety in high-risk populations.
- EligibilityCriteria: Inclusion Criteria:  Individuals who are older than 18 years of age Individuals who are planned to undergo an MRI-guided biopsy based on high- risk screening imaging detected lesions Individuals with the ability to understand and the willingness to sign a written informed consent document  Exclusion Criteria:  High-risk Individuals with screening-imaging studies without suspicious lesions detected by the standard of care mammogram and/or MRI Individuals who are pregnant or who think they may be pregnant Individuals who are breast-feeding - HealthyVolunteers: No - Gender: Female - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult