A Trial to Learn How Well REGN9933 and REGN7508 Work for Preventing Blood Clots, and How Safe They Are, in Adults Who Have a Peripherally Inserted Central Catheter (PICC)
This study is researching 2 different experimental drugs called REGN9933 and REGN7508 (called "study drugs"). The study is focused on adults undergoing a placement of a catheter in your vein, also called a 'PICC line'.

The aim of the study is to see how effective the study drug is at preventing venous thromboembolism (VTE) and other related disease after catheter placement.

The study is looking at several other research questions, including:

What side effects may happen from taking the study drug
How much study drug is in your blood at different times
Whether the body makes antibodies against the study drug (which could make the drug less effective or could lead to side effects)
- EligibilityCriteria: Key Inclusion Criteria:  PICC is anticipated to remain in place for at least 14 days Eastern Cooperative Oncology Group (ECOG) Performance Status ≤2 or equivalent functional status as described in the protocol Body weight ≥50 kg and ≤130 kg during the screening period International normalized ratio (INR) and aPTT values at or below the upper limit of normal as defined by the local lab during the screening period Platelet count ≥100 x 10^9/L during the screening period as described in the protocol  Key Exclusion Criteria:  Unsuccessful PICC placement or any other complication associated with this procedure that in the opinion of the study investigator may present any safety concerns to the participant History of prior venous thrombosis in the arm in which the PICC is to be placed History of known thromboembolic disease or thrombophilia Participants requiring therapeutic or prophylactic anticoagulation and/or antiplatelet therapy as described in the protocol Expected to receive cancer therapy or other medication associated with a prior episode of Grade 4 thrombocytopenia as described in the protocol Any history of intracranial or intraocular bleeding, excessive operative or post-operative bleeding, traumatic spinal or epidural anesthesia, or history of bleeding diathesis (eg. Hemophilia A or B, von Willebrand's disease)  Note: Other protocol defined inclusion/exclusion criteria apply - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult