Spatial Transcriptomics in Kidney Transplantation
The study is an investigator-led, prospective, longitudinal, observational cohort study.

The central hypothesis for this study is that spatial data will reveal new insights to immune cell function and local interactions within the kidney tissue to better predict important clinical outcomes. Investigators aspire to establish a prospective, longitudinal cohort to improve the diagnosis and management of kidney transplant rejection using precision pathology.

By utilising new spatial technologies, the investigators aim to:

Derive a spatially resolved transcriptomic signature of kidney transplant rejection subtypes
Derive accurate transcriptomic signatures aligned with key cell types within the transplant kidney
Develop refinements to histological kidney rejection diagnostic and scoring classification
Correlate of spatial and refined biopsy scoring features to clinically important outcomes
- EligibilityCriteria: Inclusion Criteria:  All participants included in the study must be age ≥ 18 years old at time of enrolment and  able to provide informed consent (interpreter permitted) for enrolment consenting to longitudinal follow up (can withdraw post enrolment) consenting to provide samples for biobanking, including blood, urine, faecal and/or kidney biopsy tissue (collected prospectively, separate to routine care)  Exclusion Criteria:  Patients will be excluded from the study if they are  unable (or unwilling) to provide consent, or have life-expectancy less than 6-months, or have received a haematopoietic stem cell transplant in the past 5 years. - Gender: All - MinimumAge: 18 Years - MaximumAge: 75 Years - StdAgeList: Adult, Older Adult - StudyPopulation: Kidney transplant (or kidney-pancreas transplant) recipients consenting to this study. - SamplingMethod: Probability Sample