The Protection of Thyroid Function in IMRT for Nasopharyngeal Carcinoma
This study aimed to reduce radiation-induced thyroid injury without compromising control of the cervical region by optimizing the delineation of the cervical lymph node drainage area.
- EligibilityCriteria: Inclusion Criteria:  The pathological diagnosis was newly diagnosed non-keratinizing squamous cell carcinoma nasopharyngeal carcinoma. The clinical stage is T1-4N0-3M0 (stage I~IVa, UICC/AJCC 8th edition); There is no history of hypothyroidism or hyperthyroidism before treatment; Using intensity-modulated radiotherapy technology, Complete radical dose radiotherapy; KPS≥70 points; Age 18-70 years old; Male or female who is not pregnant or lactating; Hematological examination: white blood cells > 4×109/L, neutrophils > 2×109/L, hemoglobin > 90g/L, platelets > 100×109/L; Liver function: ALT, AST < 1.5×ULN, ALP < 2.5×ULN, bilirubin < ULN. Renal function: creatinine > 60 ml/min; The patient signs the informed consent form;  Exclusion Criteria:  WHO pathological classification is keratinizing squamous cell carcinoma or basaloid carcinoma; palliative treatment; Have a history of other malignant tumors; Pregnant or lactating women (women of childbearing age should consider taking a pregnancy test, and patients are required to use effective contraception during treatment); Have a history of neck surgery; Have a history of hyperthyroidism or hypothyroidism. Previous history of head and neck radiation therapy; - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 75 Years - StdAgeList: Adult, Older Adult