Cold and Heat Investigation to Lower Levels of Depression
This study will recruit 112 medically healthy adults (aged 18-65) currently experiencing depressive symptoms to be randomized to receive either a single Whole Body Hyperthermia (heat therapy) treatment or a Whole Body Hyperthermia treatment followed by a cold water plunge. Participants will complete a baseline assessment of their depressive symptoms as well as 1-week and 2-week post-treatment followup assessments.
- EligibilityCriteria: Inclusion Criteria:  Meets DSM 5 criteria for major depressive disorder (MDD) with a depressive episode of ≥ 60 days duration. Montgomery-Asberg Depression Rating Scale (MADRS) score ≥ 28 at screening English or Spanish speaking (able to provide informed consent and complete questionnaires in one of these languages) Able and willing to adhere to trial requirements, including attending all trial visits, preparatory and follow-up sessions, and completing all trial evaluations.  Exclusion Criteria:  Previous adverse reaction to hypothermia, hyperthermia and/or infrared exposure Use of any medication that may impact thermoregulatory capacity. Pregnancy, active lactation, or intention to become pregnant during the study period. Endorses current active suicidal ideation with a plan or made a suicide attempt in the prior 6 months. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 65 Years - StdAgeList: Adult, Older Adult