Comparison of Intravenous Lidocaine vs Ketamine in Colorectal Surgery
Patients undergoing open colorectal surgery were randomly divided into two groups: Intravenous Lidocaine (IV-Lido) vs Intravenous Ketamine (IV-Keta).

For the IV-Lido group, patients received a loading dose of Lidocaine than a continuous infusion over twenty-four hours.

For the IV-Keta goup, patients received a loading dose of Ketamine than a continuous injection of Ketamine over twenty-four hours.

Plasma concentrations of Interleukin-6(IL-6) were measured preoperatively before anesthetic induction and at twenty-four hour post operatively.
- EligibilityCriteria: INCLUSION CRITERIA:  Patients aged 18 or older. American society of anesthesiologists' (ASA) physical status of I-III. Elective open colorectal surgery.  NON INCLUSION CRITERIA:  Patients with contraindications to lidocaine or ketamine. Corticosteroid therapy within the last 6 months. History of immunosuppressive therapy. History of surgery in the last 3 months. Personal medical history of inflammatory bowel disease. Personal medical history of cardiac arrythmias or conduction disorders. Alcohol or drug abuse. Chronic use of opioids or benzodiazepines.  EXCLUSION CRITERIA:  Severe intraoperative complications. Duration of surgery longer than 5 hours. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 90 Years - StdAgeList: Adult, Older Adult