Eye-tracking Investigation of Clinical Measures in Multiple Sclerosis
The overarching goal of this research protocol is to acquire eye-tracking, cognitive, and disease-severity metrics in MS patients to train machine learning algorithms that will support the development and performance assessment of a sensitive and non-invasive eye-tracking software application. The training of our machine learning classifying algorithms to identify which eye-tracking metrics-or combination thereof-can serve as reliable markers of MS disease severity and cognitive status.
- EligibilityCriteria: Inclusion Criteria:  Able to provide informed consent Aged 18 years or older at the time of enrollment Able to read in either French or English Able to read the oculomotor task on-screen instructions at the testing distance (45cm) with or without corrective lenses Confirmed diagnosis of MS as per the Macdonald criteria, irrespective of MS subtype (relapsing-remitting (RRMS), secondary-progressive (SPMS), primary-progressive (PPMS), and progressive-relapsing (PRMS)) Neurologist-determined EDSS score between 1.0-8.0  Exclusion Criteria:  Evidence or medical history of psychiatric issues, which are known to also affect movements and oculomotor control Presence of comorbid neurological conditions to avoid eye movement anomaly confounds (Strabismus, cranial nerve palsy, stroke-causing hemianopsia) Diagnosis of macular edema or other pre-existing ocular conditions that would prevent a participant from performing the eye movement assessments Having started a new prescription medication or having changed the dose of a medication known to influence ocular motor visual function (e.g. benzodiazepines, antipsychotics and anticonvulsants) within the past three months Participants with non-disease related physical impairments to a leg, hand, or arm (e.g., broken bone or severe sprain) that would not allow completion of the assessments - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult - StudyPopulation: Our target sample size for the MS group is up to 100 patients. Eligible patients with MS will be selected and categorized based on their EDSS score. - SamplingMethod: Non-Probability Sample