Blood Flow Restriction in Improving Muscle Strength of Patients With Hemophilic Ankle Arthropathy
Background. The main physical sequela of patients with hemophilia is the development of a progressive, degenerative intra-articular lesion, known as hemophilic arthropathy). This sequela is manifested by chronic pain, limited range of motion, axial abnormalities, and periarticular muscle atrophy.

Objective. To assess the safety and effectiveness of an intervention through blood flow restriction, regarding the frequency of bleeding and the improvement in muscle activation and strength, range of motion, stability, joint pain, joint status and the perception of quality of life in patients with hemophilic ankle arthropathy.

Study design. Randomized, multicenter, single-blind clinical study. Method. 32 patients with hemophilia A and B will be recruited in this study. Patients will be recruited in 4 regions of Spain. The dependent variables will be: bleeding frequency (self-registration), pain (measured with the visual analog scale and pressure algometer), quality of life (SF-36 scale), joint status (Hemophilia Joint Health Score scale), strength (dynamometer) and muscle activation (surface electromyograph), range of motion (goniometer) and stability (The Single Leg Stance Test). Three evaluations will be carried out: pre-treatment, post-treatment and after a follow-up period of 4 weeks.

Expected results. Observe the safety of blood flow restriction in hemophilia patients. To analyze the efficacy of blood flow restriction in improving muscle strength and activation, range of motion, chronic pain, stabilit, and the perception of quality of life in patients with hemophilic ankle arthropathy.
- EligibilityCriteria: Inclusion Criteria:  Patients diagnosed with hemophilia A and B People with a medical diagnosis of hemophilic ankle arthropathy Patients over 18 years of age Paceinets in prophylactic or on-demand treatment regimen with FVIII/FIX concentrates. Failure to sign the informed consent document  Exclusion Criteria:  Patients with neurological or cognitive alterations that prevent understanding of the questionnaires Amputee patients, epileptics or patients with severe vision problems Patients who are receiving physiotherapy treatment at the time of the study - HealthyVolunteers: No - Gender: Male - MinimumAge: 18 Years - MaximumAge: 55 Years - StdAgeList: Adult