Arterial Wall Shear Stress After Intracranial Artery Recanalization
There has been consistent research on the cerebral blood flow features in ischemic stroke patients with acute occlusion of major intracranial arteries. However, studies analyzing the overall features of the major intracranial artery blood flow in the periods of pre and post-recanalization are still lacking. Time-of-flight magnetic resonance angiography (TOF-MRA) is extensively utilized to evaluate the intracranial arteries. The arterial signal intensity from MRA-TOF varies across subjects and arterial subtypes, leading to the development of the Signal Intensity Gradient (SIG) concept. SIG has demonstrated a strong correlation with Computational Fluid Dynamics (CFD), a known method for reflecting wall shear stress. SIG could be associated with the pathophysiology of wall shear stress. We aim to investigate the blood flow patterns and characteristics in the periods of pre and post-recanalization using SIG.
- EligibilityCriteria: Inclusion Criteria:  Individuals aged 18 years and above Presenting with acute neurological impairments and demonstrating occlusion of major cerebral arteries (inclusive of one or more of the internal carotid artery, anterior cerebral artery, middle cerebral artery, posterior cerebral artery, vertebral artery, or basilar artery) as evidenced by brain MRA examinations Arterial recanalization subsequent to interventions such as intravenous thrombolysis and/or endovascular thrombectomy. Verification of the recanalized arteries on subsequent brain MRA imging Availability of source images from intracranial TOF-MRA (stored in DICOM format) both before and after arterial recanalization  Exclusion Criteria:  Absence of TOF-MRA imaging either before or after arterial recanalization Brain MRI was performed, but TOF-MRA (DICOM source images) are missing Image analysis is deemed challenging due to the quality of the Brain MR images Intervention for vascular recanalization was unsuccessful, or re-occlusion was observed in the follow-up brain MRA - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult - StudyPopulation: Patients who presented to a medical center with acute neurological deficits and were confirmed to have acute occlusion in a major cerebral artery. - SamplingMethod: Probability Sample