Preoperative (Pre-amputation) Cryoanalgesia to Improve Post-amputation Phantom Limb Pain
Investigators will evaluate preamputation cryoanalgesia on pain, mobility, opioid use and general physical and emotional disability using a pilot randomized trial design, to explore the amount and variability of improvement on those outcomes and to investigate the potentiality of conducting a future larger randomized controlled trial, which the investigators will assess quantitatively the benefits of cryoanalgesia.
- EligibilityCriteria: Inclusion Criteria:  Adults at least 18 years of age. Scheduled for a unilateral lower limb amputation distal to the femoral head and including at least one metatarsal bone.  Exclusion Criteria:  Pregnancy Incarceration Morbid obesity (body mass index greater than 40 kg/m2 Contraindication specific to cryoneurolysis such as a localized infection at the treatment site, cryoglobulinemia, cold urticaria, or Reynaud's syndrome. Investigator opinion that the potential subject is a poor candidate for this trial. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult