Metabolomics and Bariatric Surgery in Patients With Metabolically Unhealthy Obesity
The goal of this observational study is to investigate metabolic changes in individuals undergoing bariatric surgery, specifically focusing on those with obesity and varying metabolic health statuses. The main questions it aims to answer are:

Can metabolic markers predict the transition from metabolically unhealthy obesity to metabolically healthy obesity after bariatric surgery?
How do metabolic profiles change in individuals with metabolically healthy obesity after bariatric surgery?
What are the metabolic differences between individuals with metabolically healthy and unhealthy obesity before and after bariatric surgery?

Participants will undergo routine evaluations and blood tests before and after bariatric surgery. These tests will include assessments of metabolic health markers and sampling of blood plasma for metabolomic analysis. The study will study changes in metabolic profiles between individuals who transition to metabolically healthy obesity and those who remain metabolically unhealthy after surgery.
- EligibilityCriteria: Inclusion Criteria:  Patients undergoing bariatric surgery at the Hospital del Mar in Barcelona. Criteria for bariatric surgery are:  Ages between 18 and 60 years. Body Mass Index (BMI) equal to or greater than 40, or equal to or greater than 35 kg/m2 with at least one obesity-related comorbidity (type 2 diabetes mellitus, hypertension, dyslipidemia, obstructive sleep apnea syndrome). Previous failure with conventional treatment involving diet and exercise.  Exclusion Criteria:  History of previous bariatric surgery. Presence of severe psychiatric disorders, severe eating disorders, alcohol or drug abuse. Contraindications for major abdominal surgery, active gastric ulcer, severe liver disease.  Pregnancy or lactation. - Gender: All - MinimumAge: 18 Years - MaximumAge: 60 Years - StdAgeList: Adult - StudyPopulation: The study population will consist of patients who have undergone bariatric surgery at the Hospital del Mar in Barcelona and meet the aforementioned inclusion criteria. These patients will be consecutively selected and must agree to participate in the study. - SamplingMethod: Non-Probability Sample