Cardioneuroablation for Bradyarrhythmia
This is a multicenter prospective randomized blind controlled trial with a sham procedure group of the efficacy and safety of cardioneuroablation as a method of treating symptomatic bradycardia without a permanent pacemaker implantation
- EligibilityCriteria: Inclusion Criteria:  Any of the following variants of bradyarrhythmia in patients aged 18-65 years:  (1.1.) Symptomatic sinus bradycardia or bradycardia due to atrioventricular blockade, including transient.  (1.2.) Severe asymptomatic sinus bradycardia with a rhythm frequency of <30 beats/min.  (1.3.) Transient atrioventricular block of II-III degree or permanent block of II degree.  (1.4.) Repeated fainting or pre-fainting states with a proven association with bradycardia (without injury).  (1.5.) Rhythm pauses >6 seconds.  In combination with the following two criteria:  Positive reaction to physical activity and/or atropine test:  (2.1.) Increase in sinus rhythm frequency ≥25% or >90 beats/min. (2.2.) The transition of atrioventricular blockade of the II-III degree to the 1st degree or complete normalization of atrioventricular conduction at the sinus rhythm.  Sinus rhythm at the time of switching on  Exclusion Criteria:  Anamnesis of injury during syncopation due to bradycardia, except in the case when the patient refused to implant an electrocardiostimulator for his own reasons in writing; Constant intake of antiarrhythmic drugs (for PVC, AF, etc.); The presence of an implanted pacemaker, a heart contractility modulation device, a cardioverter defibrillator; Drug-induced sinus bradycardia and/or atrioventricular block; Bradycardia due to electrolyte imbalance (e.g. hyperkalemia); Bradycardia due to hypothyroidism or other reversible conditions; No reaction to the administration of atropine (up to a maximum dose of 0.2 mg / kg); Proven association of bradyarrhythmia with episodes of apnea/hypopnea in obstructive sleep apnea syndrome; Clinically significant coronary artery disease; Postinfarction cardiosclerosis; Hemodynamically significant congenital heart defects, including operated ones; Stroke or transient ischemic attack <3 months; Open heart surgery in the anamnesis; Catheter interventions on coronary arteries or for cardiac arrhythmias <3 days; Conditions after percutaneous coronary angioplasty <3 months; Anamnesis of stable ventricular tachycardia on the background of bradycardia; Pregnancy or breastfeeding period - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 65 Years - StdAgeList: Adult, Older Adult