Removal Of CytoKines With cytoSorbenTs After Imflammatory Response Reaction During Cardiac Surgery
Detailed knowledge about the association between systemic inflammation and endothelial progenitor cell (EPCs) activation during extracorporeal circulation (ECC) is lacking.

This pilot study aims to clarify the relationship between CD34-positive EPCs and cytokine release during ECC using the cytokine adsorber to make a predictive statement regarding the clinical expression of inflammation.
- EligibilityCriteria: Inclusion Criteria:  planned cardiac surgical procedure with the use of the cardiopulmonary machine as well as with ECMO use (elective or urgent) age at the time of surgery of &gt;18 years. informed consent  Exclusion Criteria:  An emergency indication; endocarditis, a non-sterile inflammation, autoimmune diseases, chronic inflammatory diseases (ankylosing spondylitis, psoriasis, rheumatoid arthritis, chronic inflammatory intestinal diseases), an acquired immune deficit (HIV); severe liver dysfunction, hepatitis B/0; patients on dialysis; Patients with a hematopoietic disorder/tumour disease; participation in other interventional trials or studies; timely and probable follow-up cannot be guaranteed (e.g. due to long distances between home and study site); a pregnancy that cannot be excluded with certainty (no menopause, no sterilization). - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult