Efficacy of Hyaluronic Acid Injection in Knee Osteoarthritis
The aim of this clinical trial study is to compare the efficacy of Hyaluronic injection in patients with symptomatic knee osteoarthritis. The main questions it aims to answer are:

Is Hyaluronic acid injection improve pain symptom, joint stiffness, and joint function in patients with knee osteoarthritis
Is Hyaluronic acid injection improve knee performance status and health-related quality of life in patients with knee osteoarthritis

Participants will be allocated to receive one treatments; either Hyaluronic acid or normal saline injections after receiving glucocorticoid injection.

Researchers will compare the Hyaluronic acid with normal saline injection to see if the former show superior effect in terms of pain, joint stiffness, function, as well as health-related quality of life comparing with placebo.
- EligibilityCriteria: Inclusion Criteria:  All participants who had been diagnosed as knee osteoarthritis according to ACR criteria with symptom of knee pain Pain visual analog scare of 4 or higher  Exclusion Criteria: Participants who have  Cognitive impairment History of aller to Hyaluronic acid or its component History of knee arthropathy Concomitant with inflammatory arthritis Serious comorbidities or bedridden status Current pregnancy or lactation Currently use of symptomatic slow acting drugs for osteoarthritis (SYSADOA) Communication problem - HealthyVolunteers: No - Gender: All - MinimumAge: 50 Years - StdAgeList: Adult, Older Adult