Effect of Changes in Carbohydrate Intake on Glucose Control in Patients With Type 1 Diabetes
The blood glucose fluctuates greatly in T1DM patients, especially in the middle and late stages of the disease, and carbohydrate (CHO) is the main determinant of postprandial glucose response (PGR). Based on the previous investigation to understand how nutritional habits affect blood glucose control, we will conduct dietary intervention studies in T1DM patients to explore whether the adjustment of dietary pattern is beneficial to blood glucose control, and further explore the relevant mechanism through the detection of related metabolic indicators.
- EligibilityCriteria: Inclusion Criteria:  Those who agree to participate in the study and sign informed consent; Diagnosis of type 1 diabetes mellitus (ADA2024); Age of 18~65 years; Dependent on exogenous insulin therapy (CSII), the treatment plan remains unchanged within 2 months (the type of insulin cannot be changed, and the dose can be adjusted according to plasma glucose); Body mass index (BMI) of 18~24 kg/m2; HbA1c ≤9.5%; Random C-peptide ≥200pmol/L.  Exclusion Criteria:  Honeymooners with type 1 diabetes mellitus; Women who are pregnant or plan to become pregnant; Patients who are vegetarians; Patients who are users of oral hypoglycemic drugs (alpha-glucosidase inhibitors, DPP-IV inhibitors, etc.); Patients who are users of glucocorticoids within 30 days; History of severe food allergy; Patients with acute complications such as DKA; Patients with gastroparesis, inflammatory bowel disease and other complications; Patients with large albuminuria and renal insufficiency; Patients with uncontrolled hyperthyroidism and hypothyroidism; History of heart disease, coronary heart disease and arrhythmia; Serious of liver dysfunction (ALT or AST>1.5 times the upper limit of normal); History of malignant tumors, uncontrolled other immune system diseases, uncontrolled infections; Alcohol abuse, mental disorders or other conditions unfit to be an observer in drug tests; Patients with any disease likely to interfere with study participation or evaluation. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 65 Years - StdAgeList: Adult, Older Adult