Validation of the ProSomnus® RPMO2 Device
The purpose of the study is to:

Evaluate the SpO2 accuracy of the oximeter component of the ProSomnus RPMO2 Device during non-motion conditions over the range of 70-100% SaO2 by comparison to SaO2 values determined by arterial blood sample specimen analyzed by a CO-oximeter.
Evaluate the pulse rate performance simultaneously collected over the SpO2 range.
- EligibilityCriteria: Inclusion Criteria:  Male or female, aged ≥ 18 and < 50 years. In good health with no evidence of medical problems. Ability to provide informed consent and willingness to comply with the study procedures. Ability to undergo controlled hypoxemia to the levels outlined in the desaturation profile. Adequate dentition for an oral appliance. Ability to breathe through the nose comfortably.  Exclusion Criteria:  Obesity (BMI > 40 kg/m2). Known history of heart, lung, kidney, or liver disease. Diagnosis of asthma or sleep apnea. Diagnosis of diabetes. Presence of a clotting disorder. Presence of hemoglobinopathy or history of anemia that, in the opinion of the PI, makes the individual unsuitable for participation. Current smoker. History of fainting or vasovagal response. History of sensitivity to local anesthesia. Unacceptable collateral circulation based on exam (Allen's test). Pregnancy or lactation. Resting heart rate > 120 bpm. Systolic BP > 150, diastolic BP > 90. Carboxyhemoglobin level > 3%. Presence of any other condition that, in the opinion of the PI, makes the individual unsuitable for participation. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge: 50 Years - StdAgeList: Adult - StudyPopulation: The study will include volunteers who have previously been determined to be healthy enough for the study and who have signed an informed consent form and met the eligibility criteria.  A minimum of 10 healthy participants will be recruited to complete the test protocol. A minimum of two participants or 15% of the participant pool (whichever is larger) will have Fitzpatrick Skin type IV, V, or VI (i.e., darkly pigmented skin). - SamplingMethod: Non-Probability Sample