Low Dose Aspirin for Prevention of Early Pregnancy Loss
Preeclampsia is a pregnancy-specific, multisystem disorder affecting 3% to 8% of pregnancies and remains a significant cause of maternal and neonatal morbidity and mortality worldwide.

The World Health Organization estimates that approximately 76,000 maternal deaths annually are attributed to preeclampsia, accounting for 16% of global maternal mortality, with the majority occurring in low- and middle-income countries
- EligibilityCriteria: Inclusion Criteria:  Singleton pregnancy Before 8 weeks gestation Women at high risk of preeclampsia according to Royal College of Obstetricians and Gynecologists (RCOG) (Robson et al., 2013): Maternal age ≥ 35 years. Nulliparity. BMI ≥ 30 kg/m2. Smoking of r ≥ 10 cigarettes per day. Previous history of small for gestational age (SGA) baby. Previous history of stillbirth. Pregnancy interval < 6 months or ≥ 60months. Chronic hypertension. Diabetes with vascular disease. Willingness to participate in the study and provide informed written consent.  Exclusion Criteria:  Known allergy or hypersensitivity to aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) Use of any anticoagulant medication (e.g., heparin, warfarin, clopidogrel) Use of low-dose aspirin for any indication prior to the current pregnancy Chronic use of NSAIDs or corticosteroids History of bleeding disorder or active bleeding Any medical condition that may contraindicate the use of low-dose aspirin (e.g., peptic ulcer disease, asthma, liver, or kidney disease) Multiple gestation Inability to provide informed consent or comply with the study requirements. - HealthyVolunteers: No - Gender: Female - MinimumAge: 18 Years - MaximumAge: 40 Years - StdAgeList: Adult