Assessment of Skin Barrier Disruption Due to Daily Use of Cleaning Products and Hand Disinfectants
The goal of this clinical trial is to assess the effects of household detergents and hand disinfectants on human skin barrier integrity among healthy adult volunteers.

The main questions it aims to answer are:

How does exposure to household detergents and hand disinfectants impact skin barrier function?
Are there differences in skin barrier disruption between various types of cleaning agents and disinfectants?

Participants will:

Undergo patch testing with controlled amounts of household detergents and hand disinfectants on a small area of their skin.

Be monitored for adverse reactions during and after exposure. Have their skin barrier integrity assessed using electrical impedance spectroscopy at multiple time points post-exposure.

If there is a comparison group:

Researchers will compare the effects of different types of cleaning agents, hand disinfectants, and their ingredients on skin barrier integrity to determine variations in their impact.
- EligibilityCriteria: Inclusion Criteria:  The study population will consist of healthy adult volunteers; 1. age between18 and 65 years, 2. Generally healthy and able to provide written informed consent. The choice of healthy adult volunteers without pre-existing skin conditions on site or allergies against tested products is justified.  Exclusion Criteria:  Severe dermatitis, eczema, psoriasis, or other chronic skin conditions. History of hypersensitivity or allergies to tested product ingredients. Current or recent systemic therapy for a skin condition in the past six months. Pregnant or breastfeeding individuals. Use of investigational drugs or participation in another trial in the last 30 days. History of skin cancer or malignancies in the study area. Significant sunburn, open wounds, or active skin infections in the study area. Any medical condition that, per the investigator, might compromise safety or confound results. Inability to follow study instructions or attend required clinic visits. Gender Balance: To ensure gender balance, efforts will be made to recruit an equal number of male and female participants. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - MinimumAge: 18 Years - MaximumAge: 65 Years - StdAgeList: Adult, Older Adult