Kinesiological / Dietary Supplement Intervention in Knee Osteoarthritis
The goal of this clinical trial is to assess the effectiveness of dietary supplement combined with exercise in managing knee osteoarthritis (KOA). The main questions it aims to answer are:

Is adding a dietary supplement to exercise additionally effective in managing KOA?
Is adding exercise to the dietary supplement additionally effective in managing KOA?

Participants will be given in three groups:

Real dietary supplement alone
Real dietary supplement with exercise
Placebo dietary supplement with exercise

Investigators will compare groups 1 and 2, or 2 and 3, to answer the research questions.

The hypothesis is that participants who receive the dietary supplement along with exercise will experience greater reduction in pain level, improved physical function, and enhanced quality of life compared to those who receive a placebo combined with exercise or dietary supplement alone.
- EligibilityCriteria: Inclusion Criteria:  knee osteoarthritis of one or both knee severity of knee osteoarthritis based on Kellgren-Lawrence radiographic grade 1-3  Exclusion Criteria:  Age <55 years Kellgren & Lawrence grade 4 of knee osteoarthritis Acute knee injuries within the last 6 months Knee pain not associated with knee osteoarthritis History of knee or hip endoprosthesis Surgery on the back, hip, knee, ankle, or foot within the last 12 months Health issues or musculoskeletal limitations affecting strength training and mobility more than knee pain (e.g., lower back pain, hip pain) Neurological conditions (Alzheimer's disease, Parkinson's disease, metabolic diseases affecting the nervous system) Muscular or joint diseases/injuries affecting lower limb function (e.g., hip and/or ankle osteoarthritis, sprains, fractures) Internal medical conditions (cardiovascular, pulmonary, oncological, diabetes with late complications - diabetic foot, neuropathies) affecting physical performance Stroke or similar condition with consequences on motor skills and/or cognition (inability to provide consent) Balance disorders, known vestibular system impairment Body Mass Index > 32 Structured strength training exceeding 30 minutes per week Corticosteroids and/or hyaluronic acid (intra-articular) use in the last 3 months Individuals taking joint health dietary supplements, like glucosamine, chondroitin, or collagen, will need to halt use for at least 14 days before measurements to avoid affecting study outcomes - HealthyVolunteers: No - Gender: All - MinimumAge: 55 Years - StdAgeList: Adult, Older Adult