Effectiveness of TTNS in MS Patients With Lower Urinary Track Symptoms
Multiple sclerosis (MS) is the most common inflammatory disease of the central nervous system. It is characterized with demyelinated plaques affecting subcortical, brain stem, and spinal cord nerve fibers. During the course of the disease, with the affection myelinated nerve tracks, lower urinary track symptoms may occur. 50-90% of the MS patients experience lower urinary track symptoms (LUTS) such as urinary incontinence, urgency, nocturia and/or urinary frequency during the at one point of their life.

Aim of this study is to determine the effects of transcutaneous tibial nerve stimulation (TTNS) on symptoms and quality of life in MS patients with LUTS.
- EligibilityCriteria: Inclusion Criteria:  Volunteer Adults (Age 18-50) Diagnosis of Multiple Sclerosis Expanded Disability Status Scale (EDSS) 0-6,5 Lower urinary track symptoms (Urinary incontinence, urgency, nocturia and/or urinary frequency) Diagnosis of bladder disfunction with Urodynamic study within 1 months  Exclusion Criteria:  Age less then 18 Pacemaker or implantable defibrillator usage Diabetic polyuria Bleeding diathesis or severe bleeding tendency Pelvic floor disfunction or nerve damage effecting tibial nerve Currently pregnant or planning pregnancy Active urinary infection Active malignancy Severe mental disability Cognitive deficit Expanded Disability Status Scale (EDSS) greater than or equal to 7 Unable to attend to TPTNS treatment 2 times a week Urodynamic findings of bladder outlet obstruction Surgical history because of urinary incontinence Urologic surgical history because of lower urinary track disfunction or symptoms Diagnosis of prostatic enlargement Diagnosis of pelvic organ prolapse - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - MaximumAge: 50 Years - StdAgeList: Adult