Activity of Chronic Inflammation in PCOS
Chronic inflammation in polycystic ovary syndrome (PCOS) may be the result of dysregulation of cytokine production (due to insulin resistance, excess visceral fat and hyperandrogenemia), i.e., overproduction of pro-inflammatory factors (e.g. TNF, IL-1, IL-6) in relation to anti-inflammatory ones (IL-10). This condition may be an important link between obesity and insulin resistance, which is crucial in the etiopathogenesis of the syndrome. However, it is not known whether it results from the tendency to accumulate adipose tissue or is a feature of the syndrome itself. There is no data indicating the relationship between chronic inflammation and the severity of metabolic disorders and the value of ovarian reserve in women with various PCOS phenotypes.
- EligibilityCriteria: Inclusion Criteria:  age 18-45 years PCOS syndrome confirmed by the Rotterdam criteria  Exclusion Criteria:  absence of at least one ovary diagnosed and/or treated other metabolic disease diagnosed and/or treated other endocrine disease - Gender: Female - MinimumAge: 18 Years - MaximumAge: 45 Years - StdAgeList: Adult - StudyPopulation: Women aged 18-45, treated at the University Hospital in Krakow, diagnosed with PCOS confirmed by the Rotterdam criteria, phenotypes A, B, C, D, without other metabolic and endocrine diseases. - SamplingMethod: Non-Probability Sample