Renal Assessment for Early Detection of Renal Impairment in Systemic Sclerosis and Systemic Lupus Erythematosus Patients
Evaluate renal resistive index in SSc and SLE patients for early detection of renal impairment.
Evaluate renal multi-parametric MRI in SSc and SLE patients for early detection of renal impairment.
Measure the serum levels of CD147 in SSc and SLE patients and its correlation with renal impairment.
Correlation between detected markers and other assessment tools.
- EligibilityCriteria: Inclusion Criteria:  Adult (aged above 18 years) SSc patients who fulfilled the 2013 European League Against Rheumatism/American College of Rheumatology (EULAR / ACR) for SSC [13] and 1980 ACR criteria [14]. Adult SLE Patients who fulfilled the 2019 EULAR / ACR classification criteria for systemic lupus erythematosus [15]  Exclusion Criteria:  Individuals with other autoimmune diseases. Smoking. Infections as chest infection, hepatitis C, hepatitis B and HIV infection. Tumors as hepatocellular carcinoma. Hypertension, diabetes, heart failure, hepatic diseases, chronic renal failure, intrarenal arteriovenous fistula, obstructive nephropathy and urinary tract obstruction. Contraindication for MRI as implanted metallic devices. - Gender: All - MinimumAge: 18 Years - MaximumAge: 70 Years - StdAgeList: Adult, Older Adult - StudyPopulation: The study will include adult SSc and SLE patients consecutively presented at the rheumatology, rehabilitation and physical medicine department, Assiut university hospital from both inpatient department and outpatient clinic - SamplingMethod: Non-Probability Sample