Effect of Non-chirurgical Periodontal Treatment on the Immune System From a Gender Perspective
The goal of this observational study is to evaluate non-surgical periodontal treatment in women and men with periodontitis with and without obesity. The main questions it aims to answer are:

If non-surgical periodontal treatment of patients with chronic periodontitis can modulate the innate and adaptive immune response taking into account patient gender and the coexistence of obesity
If there are specific miRNAs that can regulate this immune response and can be considered as suitable biomarkers and therapeutic targets.

Obese or non-obese participants with periodontitis will receive non-surgical periodontal treatment, consisting of oral health guidance and mechanical periodontal debridement throughout the mouth using an ultrasonic device and manual curettes. Researchers will compare four groups: obese women, non-obese women, obese men, and non-obese men, to clarify the involment of immune response after treatment, considering the coexistence of obesity and potential gender differences.
- EligibilityCriteria: Inclusion Criteria:  Men/Women with periodontitis:  Periodontitis will be diagnosed according to the definition of the Centers for Disease Control and Prevention / American Academy of Periodontology (CDC/AAP).  Men/Women with obesity:  Body mass index (BMI) ≥30 kg/m2 (WHO 2000)  Exclusion Criteria:  Having fewer than fourteen teeth, Having infectious diseases Having other oral inflammatory diseases, Having received periodontal treatment in the past six months or antibiotics in the previous three months, undergoing systemic anti-inflammatory treatment, Pregnancy or lactation Serious illnesses, congenital adrenal hyperplasia, virilizing tumors, hypothyroidism, Cushing's syndrome, prolactinomas, cardiovascular diseases, or diabetes mellitus. Alcohol or drug abuse Psychiatric disorders. - HealthyVolunteers: Accepts Healthy Volunteers - Gender: All - GenderBased: Yes - GenderDescription: According to presence of periodontitis and obesity. - MinimumAge: 18 Years - MaximumAge: 69 Years - StdAgeList: Adult, Older Adult - StudyPopulation: Primary care clinic - SamplingMethod: Non-Probability Sample