Topical Tacrolimus for Breast Cancer-related Lymphedema
The goal of this clinical trial is to investigate the effect of tacrolimus ointment in women with stage I or II breast cancer-related lymphedema. The main question it aims to answer are:

How tacrolimus affects breast cancer related lymphedema regarding subjective and objective measures (e.g. arm volume, lymphedema index, lymphatic function, and quality of life).
If maintenance treatment is effective. Participants will be treated with either active drug or placebo once daily for six months followed by a six month maintenance periode with treatment twice weekly. Assessments will be performed at baseline, three, six, nine and 12 months.
- EligibilityCriteria: Inclusion Criteria:  Age over 18 years BCRL ISL stage I or II Pitting edema Postmenopausal or use of Contraceptive drugs Healthy opposite arm L-Dex score over 10  Exclusion Criteria:  Pregnant, breast-feeding, or aiming to conceive within the next year Bilateral breast cancer Contralateral lymphadenectomy Allergy to tacrolimus, macrolides, or iodine Pacemaker Known kidney or liver disease - HealthyVolunteers: Accepts Healthy Volunteers - Gender: Female - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult