Study of Acute Normovolemic Hemodilution (ANH) in People With Ovarian Cancer Who Are Having Primary Cytoreductive Surgery
Participants will be scheduled for primary cytoreductive surgery as part of their standard care. Before surgery, participants will be assigned by chance to a study group. Depending on which group they are in, they will receive either acute normovolemic hemodilution/ANH during surgery or standard surgical management during surgery. The researchers think acute normovolemic hemodilution/ANH may decrease the need for allogenic blood transfusion/ABT in people having primary cytoreductive surgery.
- EligibilityCriteria: Inclusion Criteria:  Adults (≥18 years) BLOODS score ≥3 as calculated by surgeon High preoperative suspicion of advanced primary epithelial ovarian, fallopian tube, or primary peritoneal carcinoma (stage IIIC or IV), as determined by CT or MRI of the abdomen/pelvis Planned for exploratory laparotomy and PCS Preoperative hemoglobin concentration ≥10 mg/dl within 30 days of registration Patients scheduled for PCS, with or without other planned procedures  Exclusion Criteria:  A history of active coronary artery disease  o Patients with a history of coronary artery disease will be eligible if they have had a cardiac stress study showing no reversible ischemia and normal LV function within 30 days of operation.  A history of cerebrovascular disease A history of congestive heart failure A history of uncontrolled hypertension A history of restrictive or obstructive pulmonary disease A history of renal dysfunction (Cr >1.6 mg/dl) Abnormal coagulation parameters (INR >1.5 not on coumadin, or platelet count <100,000 mcL) Presence of active infection Evidence of hepatic metabolic disorder (bilirubin >2 mg/dl, ALT >75 U/L in the absence of biliary tract obstruction) Preoperative autologous blood donation within last 30 days or plan to donate autologous blood prior to surgery Refusal to accept allogenic or autologous blood transfusion - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult