Computational Assessment of Bioprosthetic Aortic Valve Function
Bioprosthetic valves are usually made of biological tissue that are mounted to a frame and are designed to function similarly to a healthy natural valve. Edwards Magna Ease and Intuity Elite bioprosthetic valves have similar leaflets and mounting designs. However, the valves are implanted in the patient in different ways (one is stitched to the wall of the left ventricular outflow tract, and the other is held in place by the radial force of the valve skirt). The study aims to understand in more detail how the different valves interact with the left ventricular outflow tract and aortic root.
- EligibilityCriteria: Inclusion Criteria:  Male and female patients aged 18 years or over. Patients diagnosed with aortic valve disease, and scheduled to undergo Edwards Magna Ease or Intuity Elite and free of exclusion criteria below. The patient is willing and able to understand the Patient Information Sheet and provide written informed consent. The patient must agree to comply with the study imaging protocol as required at prespecified times.  Exclusion Criteria:  Inability to provide valid informed consent. Male and female patients aged < 18 years of age. Contraindications for CT angiography: renal failure (Cr>250 μmol/L or eGFR<30 mL/min) due to the additional risk of contrast medium nephrotoxicity or allergy to iodine. Women of childbearing age who have not had a hysterectomy and/or who may be breastfeeding. History of cardiac pacing device insertion, or any other MRI incompatible device implants. - HealthyVolunteers: No - Gender: All - MinimumAge: 18 Years - StdAgeList: Adult, Older Adult - StudyPopulation: 20 informed and consented patients who undergo the Intuity Elite (n=10) and Magna EASE (n=10) valves will be prospectively enrolled. The patients will be evaluated at 3- and 12-months post valve replacement. - SamplingMethod: Non-Probability Sample