Reframe this discussion about the perceived effectiveness of supplements, with a particular focus on Vitamin D, into a conversation between two health-conscious friends debating about the validity of supplements in their daily routines.

These are dark days for supplements. Although they are a $30-plus billion market in the United States alone, vitamin A, vitamin C, vitamin E, selenium, beta-carotene, glucosamine, chondroitin, and fish oil have now flopped in study after study.

If there was one supplement that seemed sure to survive the rigorous tests, it was vitamin D. People with low levels of vitamin D in their blood have significantly higher rates of virtually every disease and disorder you can think of: cancer, diabetes, obesity, osteoporosis, heart attack, stroke, depression, cognitive impairment, autoimmune conditions, and more. The vitamin is required for calcium absorption and is thus essential for bone health, but as evidence mounted that lower levels of vitamin D were associated with so many diseases, health experts began suspecting that it was involved in many other biological processes as well.

And they believed that most of us weren’t getting enough of it. This made sense. Vitamin D is a hormone manufactured by the skin with the help of sunlight. It’s difficult to obtain in sufficient quantities through diet. When our ancestors lived outdoors in tropical regions and ran around half naked, this wasn’t a problem. We produced all the vitamin D we needed from the sun.

But today most of us have indoor jobs, and when we do go outside, we’ve been taught to protect ourselves from dangerous UV rays, which can cause skin cancer. Sunscreen also blocks our skin from making vitamin D, but that’s OK, says the American Academy of Dermatology, which takes a zero-tolerance stance on sun exposure: “You need to protect your skin from the sun every day, even when it’s cloudy,” it advises on its website. Better to slather on sunblock, we’ve all been told, and compensate with vitamin D pills.

Yet vitamin D supplementation has failed spectacularly in clinical trials. Five years ago, researchers were already warning that it showed zero benefit, and the evidence has only grown stronger. In November, one of the largest and most rigorous trials of the vitamin ever conducted—in which 25,871 participants received high doses for five years—found no impact on cancer, heart disease, or stroke.
system
supplements kii kathith prabhaavashiltaa ke bare main is charchaa ko phir se namit karen, vitamin di par ek vishesh dhyaan dene ke saath, do swasthya-sachet doston ke bich baatcheet main apane dainik dincharya main poorak kii vaidhata ke bare main bahes karte hue.

ye supplements ke liye gahare din hai.yadhyapi ve akele sanyukt rajya america main $ 30 se adhik arab bazaar hai, vitamin e, vitamin si, vitamin i, selenium, beta-caroten, glucosamine, chondroitin or machhlee ke tel ab adhyayan ke baad adhyayan main flop ho gaye hai.

yadi ek poorak tha jo kathor pareekshanon se bachane ke liye nishchit lag rahaa tha, to yah vitamin di tha. unke rakt main vitamin di ke nimna str vaale log lagbhag har beemaari or vikaar kii kaaphi adhik dar hai jo aap soch sakate hai: cancer, madhumeh, motopa, motopa, motopa, motopa, motopa, motopa, motopa, motopa, motopa, motopa, motopa, motopa, motopa, motopa, motopa, motopa, motopa, motopa, motopa, motopa, motopa, motopa, motopa, motopaosteoporosis, dil kaa daura, stroke, avsaad, sangyanatmak haani, autoimmune kii sthiti, or bahut kuch.calcium avasorana ke liye vitamin kii aavashyaktaa hoti he or is prakaar haddi ke swasthya ke liye aavashyak he, lekin saboot ke rup main mount kiya gaya he ki vitamin di ke nichle str itane saare rogon se jude the, swasthya visheshgyon ko andeh hone laga ki yah kai anya jaivik prakriyaaon main bhi shaamil tha.

or unka maananaa tha ki ham main se adhikansh ise paryaapt nahin kar rahe hai.yah samaj main aayaa.vitamin di surya ke prakaash kii madad se twachaa dwaara nirmit ek hormone he.aahaar ke madhyam se paryaapt maatra main praapt karnaa mushkil he.jab hamaare purvaj ushnkaribandheey kshetron main baahar rahete the or lagbhag aadhe nagn bhaagate the, to yah ek samasya nahin thi.hamane surya se aavashyak sabhi vitamin di kaa utpaadan kiya.

lekin aaj ham main se adhikansh ke paas indoor naukariyaan hai, or jab ham baahar jate hai, to hamen khud ko khatarnaak yuvi kirnon se bachaane ke liye sikhaaya jaataa he, jisase twachaa cancer ho saktaa he.sanscreen bhi hamaari twachaa ko vitamin di banane se roktaa he, lekin yah thik he, american academy of dermatology kaa kahana he, jo suraj ke sampark main ek shunya-sahishnutaa kaa rukh letaa he: “aapako har din surya se apni twachaa kii raksha karne kii aavashyaktaa hoti he, yahaan tak ki jab yah badal tha, tab bhi, yah badal, yahaan tak ki badal chhaae rahenge,“yah apni website par salaah detaa he.Sunblock par slath karne ke liye behatar he, ham sabhi ko bataaya gaya he, or vitamin di kii goliyon ke saath kshatipurti karen.

phir bhi vitamin di poorakta naidanik pareekshanon main shandaar rup se vifal rahi he.paanch saal pehle, shodhakartaaon ne pehle se hi chetavanee di thi ki isane shunya laabh dikhaaya, or saboot keval majboot ho gaye hai.november main, vitamin ke sabase bade or sabase kathor pareekshanon main se ek jo kabhi bhi yojit kiya gaya tha - jisamen 25,871 pratibhaagiyon ko paanch saal ke liye ucch khuraaq mili - cancer, hriday rog yaa stroke par koi prabhaav nahin.
user
"are sara, kya aapane dekha he ki poorak haal hi main apni chamak kho rahe hai?"jon ne poocha, kichan counter par vitamin kii botalon kii sarani par nazar daalate hue."aap jaanate hai, vitamin e, si, i, yahaan tak ki machhlee kaa tel, ve sabhi in shodh adhyayanon main vifal ho rahe hai."

sara, uski subah kii coffee kii sargarmi, sir hilaayaa."maine yah notice kiya, lekin yah vastav main vitamin di ke bare main aashcharya kii baat thi. yah ek nishchit shart kii tarah lag rahaa tha, aap jaanate hai?"

"haan," jon sahamat hue."meraa matlab he, kam vitamin di ke str vaale logon ko bahut adhik har beemaari kaa khatra adhik hota he, jise aap soch sakate hai - cancer, madhumeh, motopa, hriday rog ... suchi aage badhati he. yah haddi ke swasthya ke liye bhi mahatvapurn he kyonki yah avashoshit karne main madad karata hecalcium. "

sara ne vichaar main apni bhunh ko uksaaya."or kyonki vitamin di hamaari twachaa dwaara suraj ke sampark main aane ke madhyam se utpann hota he, visheshgyon kaa maananaa tha ki ham paryaapt nahin ho rahe the, vishesh rup se hamaare aadhunik indoor jivan style or puure twachaa cancer ke saath, atyadhik sanscreen upyog ke liye agrani."

"bilkul!"jon ne kaha."lekin hamaari taarkik dharanaon ke baavjood, vitamin di kii khuraaq ne naidanik pareekshanon main koi mahatvapurn laabh nahin dikhaaya he. paanch saal pehle, shodhakartaaon ne pehle se hi isaki prabhaavashiltaa par sawaal uthaanaa shuru kar diya tha, or haal ke saboot keval unke sanshaywad ko majboot karte hai."

sara vichaarsheel lag rahi thi."yah sambandhit he, yah dekhte hue ki kitne log in supplements par bharosa karte hai. meraa matlab he, yaad he ki haal hi main yojit bade pareekshan? 25,000 se adhik pratibhaagiyon ke saath ucch vitamin di khuraaq praapt karne vaale paanch saal ke liye? yah cancer, hriday rog yaa stroke par koi prabhaav nahin mila.. "

jon ne sir hilaayaa, unki takataki vitamin kii botalon kii line-ap par laut rahi thi."yah nishchit rup se aapako hamaare dainik dincharya main supplements ko shaamil karne kii vaidhata ke bare main aashcharyachakit karata he, he naa?"
assistant
<|system|>
</s>
<|user|>
supplements kii kathith prabhaavashiltaa ke bare main is charchaa ko phir se namit karen, vitamin di par ek vishesh dhyaan dene ke saath, do swasthya-sachet doston ke bich baatcheet main apane dainik dincharya main poorak kii vaidhata ke bare main bahes karte hue.

ye supplements ke liye gahare din hai.yadhyapi ve akele sanyukt rajya america main $ 30 se adhik arab bazaar hai, vitamin e, vitamin si, vitamin i, selenium, beta-caroten, glucosamine, chondroitin or machhlee ke tel ab adhyayan ke baad adhyayan main flop ho gaye hai.

yadi ek poorak tha jo kathor pareekshanon se bachane ke liye nishchit lag rahaa tha, to yah vitamin di tha. unke rakt main vitamin di ke nimna str vaale log lagbhag har beemaari or vikaar kii kaaphi adhik dar hai jo aap soch sakate hai: cancer, madhumeh, motopa, motopa, motopa, motopa, motopa, motopa, motopa, motopa, motopa, motopa, motopa, motopa, motopa, motopa, motopa, motopa, motopa, motopa, motopa, motopa, motopa, motopa, motopa, motopaosteoporosis, dil kaa daura, stroke, avsaad, sangyanatmak haani, autoimmune kii sthiti, or bahut kuch.calcium avasorana ke liye vitamin kii aavashyaktaa hoti he or is prakaar haddi ke swasthya ke liye aavashyak he, lekin saboot ke rup main mount kiya gaya he ki vitamin di ke nichle str itane saare rogon se jude the, swasthya visheshgyon ko andeh hone laga ki yah kai anya jaivik prakriyaaon main bhi shaamil tha.

or unka maananaa tha ki ham main se adhikansh ise paryaapt nahin kar rahe hai.yah samaj main aayaa.vitamin di surya ke prakaash kii madad se twachaa dwaara nirmit ek hormone he.aahaar ke madhyam se paryaapt maatra main praapt karnaa mushkil he.jab hamaare purvaj ushnkaribandheey kshetron main baahar rahete the or lagbhag aadhe nagn bhaagate the, to yah ek samasya nahin thi.hamane surya se aavashyak sabhi vitamin di kaa utpaadan kiya.

lekin aaj ham main se adhikansh ke paas indoor naukariyaan hai, or jab ham baahar jate hai, to hamen khud ko khatarnaak yuvi kirnon se bachaane ke liye sikhaaya jaataa he, jisase twachaa cancer ho saktaa he.sanscreen bhi hamaari twachaa ko vitamin di banane se roktaa he, lekin yah thik he, american academy of dermatology kaa kahana he, jo suraj ke sampark main ek shunya-sahishnutaa kaa rukh letaa he: “aapako har din surya se apni twachaa kii raksha karne kii aavashyaktaa hoti he, yahaan tak ki jab yah badal tha, tab bhi, yah badal, yahaan tak ki badal chhaae rahenge,“yah apni website par salaah detaa he.Sunblock par slath karne ke liye behatar he, ham sabhi ko bataaya gaya he, or vitamin di kii goliyon ke saath kshatipurti karen.

phir bhi vitamin di poorakta naidanik pareekshanon main shandaar rup se vifal rahi he.paanch saal pehle, shodhakartaaon ne pehle se hi chetavanee di thi ki isane shunya laabh dikhaaya, or saboot keval majboot ho gaye hai.november main, vitamin ke sabase bade or sabase kathor pareekshanon main se ek jo kabhi bhi yojit kiya gaya tha - jisamen 25,871 pratibhaagiyon ko paanch saal ke liye ucch khuraaq mili - cancer, hriday rog yaa stroke par koi prabhaav nahin.</s>
<|assistant|>
"are sara, kya aapane dekha he ki poorak haal hi main apni chamak kho rahe hai?"jon ne poocha, kichan counter par vitamin kii botalon kii sarani par nazar daalate hue."aap jaanate hai, vitamin e, si, i, yahaan tak ki machhlee kaa tel, ve sabhi in shodh adhyayanon main vifal ho rahe hai."

sara, uski subah kii coffee kii sargarmi, sir hilaayaa."maine yah notice kiya, lekin yah vastav main vitamin di ke bare main aashcharya kii baat thi. yah ek nishchit shart kii tarah lag rahaa tha, aap jaanate hai?"

"haan," jon sahamat hue."meraa matlab he, kam vitamin di ke str vaale logon ko bahut adhik har beemaari kaa khatra adhik hota he, jise aap soch sakate hai - cancer, madhumeh, motopa, hriday rog ... suchi aage badhati he. yah haddi ke swasthya ke liye bhi mahatvapurn he kyonki yah avashoshit karne main madad karata hecalcium. "

sara ne vichaar main apni bhunh ko uksaaya."or kyonki vitamin di hamaari twachaa dwaara suraj ke sampark main aane ke madhyam se utpann hota he, visheshgyon kaa maananaa tha ki ham paryaapt nahin ho rahe the, vishesh rup se hamaare aadhunik indoor jivan style or puure twachaa cancer ke saath, atyadhik sanscreen upyog ke liye agrani."

"bilkul!"jon ne kaha."lekin hamaari taarkik dharanaon ke baavjood, vitamin di kii khuraaq ne naidanik pareekshanon main koi mahatvapurn laabh nahin dikhaaya he. paanch saal pehle, shodhakartaaon ne pehle se hi isaki prabhaavashiltaa par sawaal uthaanaa shuru kar diya tha, or haal ke saboot keval unke sanshaywad ko majboot karte hai."

sara vichaarsheel lag rahi thi."yah sambandhit he, yah dekhte hue ki kitne log in supplements par bharosa karte hai. meraa matlab he, yaad he ki haal hi main yojit bade pareekshan? 25,000 se adhik pratibhaagiyon ke saath ucch vitamin di khuraaq praapt karne vaale paanch saal ke liye? yah cancer, hriday rog yaa stroke par koi prabhaav nahin mila.. "

jon ne sir hilaayaa, unki takataki vitamin kii botalon kii line-ap par laut rahi thi."yah nishchit rup se aapako hamaare dainik dincharya main supplements ko shaamil karne kii vaidhata ke bare main aashcharyachakit karata he, he naa?"</s>
