It is now available for domestic markets under brand names such as Heritage and Azoxy 2SC. Azoxystrobin is added to mold-resistant Purple wallboards (optiSHIELD AT, mixture of azoxystrobin and thiabendazole) and can leach into house dust, providing a source of life-long exposure to children and adults. Azoxystrobin has little toxicity to mammals with an LD50 of over 5000 mg/kg (rats, oral). However, it can cause skin and eye irritation. First aid information is included with the label. The World Health Organization (WHO) and Food and Agriculture Organization (FAO) joint meeting on pesticide residues has determined that the acceptable daily intake for azoxystrobin is 0-0.2 mg/kg bodyweight per day. The Codex Alimentarius database maintained by the FAO lists the maximum residue limits for azoxystrobin in various food products. Azoxystrobin is categorized as having a low potential for bioconcentration and of moderate risk to fish, earthworms and bees but of high risk to aquatic crustaceans, so care must be taken to avoid runoff into water bodies. Its main degradation product, the carboxylic acid resulting from hydrolysis of its methyl ester, is also potentially harmful to aquatic environments. The benefits and risks of use of QoI fungicides have been reviewed and there is extensive literature on azoxystrobin's environmental profile. Ultimately it is the regulatory authorities in each country who must weigh up the benefits to end users and balance these against the compound's inherent hazards and consequent risks to consumers and the wider environment. Fungal populations have the ability to develop resistance to QoI inhibitors. This potential can be mitigated by careful management. Reports of individual pest species becoming resistant to azoxystrobin are monitored by manufacturers, regulatory bodies such as the EPA and the Fungicides Resistance Action Committee (FRAC). In some cases, the risks of resistance developing can be reduced by using a mixture of two or more fungicides which each have activity on relevant pests but with unrelated mechanisms of action. FRAC assigns fungicides into classes so as to facilitate this. On cereal crops in the USA, for example, azoxystrobin may only be used in mixture, usually with an azole fungicide such as difenoconazole. By international convention and in many countries the law, pesticide labels are required to include the common name of the active ingredients. These names are not the exclusive property of the holder of any patent or trademark and as such they are the easiest way for non-experts to refer to individual chemicals.