He had nine points in his first 48 games and a plus-minus of +13 when an injury to Dennis Wideman late in the season caused the Flames to recall Wotherspoon on an emergency basis. He made his NHL debut on March 7, 2014, a 4–3 victory over the New York Islanders. He recorded his first point the following night with an assist on a Brian McGrattan goal in a contest against the Vancouver Canucks. Wotherspoon appeared in 14 games with the Flames, recording four assists, before suffering a shoulder injury that required surgery and ended his season. Wotherspoon has been recalled and sent down by the Flames multiple times during the 2015-16 season. On September 5, 2017, the Flames re-signed Wotherspoon to a one-year, two-way contract worth $650,000. After five seasons within the Flames organization, Wotherspoon left as a free agent to sign a one-year, two-way contract with the St. Louis Blues on July 1, 2018. On July 1, 2019, Wotherspoon was signed to a two-year, two-way contract with the Philadelphia Flyers. Wotherspoon has a brother, Parker, who was drafted 112th overall by the New York Islanders in the 2015 NHL Entry Draft.