North of the airport, the route has a cloverleaf interchange with Wards Road, which heads south as US 29 and north as US 29 Bus.. Immediately to the north of the junction, US 460 and US 29 cross over Norfolk Southern's Danville District rail line and enter the independent city of Lynchburg. US 460 and US 29 head north along the western slope of Candlers Mountain through the campus of Liberty University. Access to the university is via five widely spaced ramps: a northbound entrance ramp from Liberty Mountain Drive, a northbound exit for Candlers Mountain Road, a southbound right-in/right-out interchange with University Boulevard near Williams Stadium, and a southbound entrance ramp from Champion Circle near the Vines Center. North of Candlers Mountain Road, US 460 and US 29 have a directional T interchange with US 501. The three U.S. Highway continue northeast across Norfolk Southern's Durham District rail line to the end of the freeway at a partial cloverleaf interchange with Campbell Avenue, which carries US 501 southeast toward Rustburg and US 460 Bus. and US 501 Bus. west toward downtown Lynchburg. US 460 and US 29 continue along four-lane divided Richmond Highway, which heads east past Falwell Airport and across Norfolk Southern's Blue Ridge District. The U.S. Highway diverge at a large trumpet interchange at the eastern city limit of Lynchburg. US 460 briefly parallels the CSX rail line that follows the south bank of the James River before the railroad and river veer north. The highway has a trumpet interchange with SR 726 (Mount Athos Road) at Kelly and crosses Beaver Creek as it heads southeast to Concord at the Appomattox County line, where SR 24 (Village Highway) joins the U.S. Highway. US 460 and SR 24 continue east parallel to the Blue Ridge District rail line through Spout Spring to the town of Appomattox. US 460 Bus. (Confederate Boulevard) splits south toward the center of town at a diamond interchange that also marks the southern terminus of SR 26 (Oakville Road). SR 24 (Old Courthouse Road) splits northeast toward Appomattox Court House National Historical Park and US 60; SR 131 heads southwest toward the center of town in the opposite direction. US 460 continues along the east side of town before it collects the other end of US 460 Bus. (Confederate Boulevard) at a directional Y interchange that has no ramp from the eastbound business route to westbound US 460. US 460 continues southeast through Evergreen and briefly rejoins the railroad at Flood.