She left the production on July 18, 2010 (along with co-stars Alice Ripley and Brian d'Arcy James). She was replaced by original Natalie standby Meghann Fahy. Following "Next to Normal", Damiano originated the role of Mary Jane Watson in the musical "" on Broadway. The show, which began previews on November 28, 2010, and, after a record-setting number of previews, opened officially on June 14, 2011, was originally directed by Julie Taymor and later by Philip William McKinley of "The Boy from Oz". After almost a year with the show, Damiano played her final performance on November 6, 2011, and was succeeded by Rebecca Faulkenberry of Broadway's "Rock of Ages", from Nov. 10. Following her departure from "Spider-Man: Turn Off the Dark", Damiano took part in a variety of readings, workshops, and concert works. In 2013, Damiano joined the Off-Broadway dystopian musical "Venice" at the Public Theater for a limited run. The cast included Haaz Sleiman, Leslie Odom, Jr., and Uzo Aduba. On November 9, 2015, it was announced that Damiano would return to Broadway (for the first time in four years) and reunite with "Spring Awakening" composer Duncan Sheik and "Next to Normal" co-star Alice Ripley in the musical adaptation of "American Psycho" in the role of Jean (as portrayed by Chloë Sevigny in the 2000 feature film of the same name). The new musical began previews on March 24, 2016, at the Gerald Schoenfeld Theatre on Broadway. In 2017, Damiano starred in Zack Zadek's musical "Deathless" at Norma Terris Theater, home of Goodspeed Musicals in Chester, CT. The show was directed by Tina Landau and began performances on June 2, 2017, ending on July 2, 2017. In December 2019, it was announced that Damiano would star alongside Ana Nogueira, Joél Pérez, and Michael Zegen in the world premiere of the screen-to-stage adaptation of "Bob & Carol & Ted & Alice" by The New Group. Damiano appeared on "Gossip Girl" in the episode entitled "It's a Wonderful Lie." In 2013, she starred in the acclaimed indie film "B-Side", her first movie. Damiano has already appeared in "Vogue", "Teen Vogue", "Vanity Fair", "Rolling Stone", and "Nylon Magazine" on behalf of her role as Mary-Jane Waston in the infamous "Spider-Man: Turn Off The Dark" musical.