In August 2017, she was among the six professional film people selected from Africa, along with successful Nigerian actor OC Ukeje to attend an intense 3-week workshop/training in Los Angeles at the Relativity School's Los Angeles Centre Studios (LACS). She was awarded a certificate in Acting for Camera. In 2010 while in preparation to shoot CHANGES season 2, Cleopatra and the principal cast that included Nick Mutuma, Pierra Makena, Nini Wacera, Patricia Kihoro were taken through acting training of The Meisner Technique by Rob Mello, a professional acting coach from Rob Mello Studios Atlanta, USA. Cleopatra studied at Nakasero Primary School (P.L.E), Bugema Adventist Secondary School (UCE) and Namasagali College (UACE) and Makerere University. She is a graduate with an Honors bachelor's degree in Social Sciences. She also has a Certificate in Community Journalism from the University of South Africa (UNISA). Cleopatra was born to Jocelyn Twinesanyu "Sanyu" Rwekikiga and Anthony Abamwikirize Bateyo in 1982. She never met her father who had been killed during the Obote II regime. Cleopatra had her first baby in 2014 with boyfriend Lwanda Jawar, a Kenyan actor, model, and stunts director/coordinator. She delivered a baby girl named Aviana Twine Jawar on 22 January 2014. She named her daughter Twine after her mother Twinesanyu. She then took a break from her career to raise her baby.