Ergine  Ergine, also known as d-lysergic acid amide (LSA) and d-lysergamide, is an ergoline alkaloid that occurs in various species of vines of the Convolvulaceae and some species of fungi. The psychedelic properties in the seeds of ololiuhqui, Hawaiian baby woodrose and morning glories have been linked to ergine and/or isoergine, its epimer, as it is the dominant alkaloid present in the seeds. Ergine has been found in high concentrations of 20 μg/g dry weight in the sleepygrass infected with an "Acremonium" endophytic fungus together with other ergot alkaloids. Ergine is a component of the alkaloids contained in the ergot fungus, which grows on the heads of infected rye grasses. It is also found in the seeds of several varieties of morning glories in concentrations of approximately 10 μg per seed, as well as Hawaiian baby woodrose seeds, at a concentration of around 0.13% of dry weight. "Ololiuhqui" was used by South American healers in shamanic healing ceremonies. Similarly, ingestion of morning glory seeds by Mazatec tribes to commune with their gods" was reported by Richard Schultes in 1941 and is still practiced today. Additional reports of the use of ergine were made by Don Thomes MacDougall. He reported that the seeds of "Ipomoea violacea" were used as sacraments by certain Zapotecs, sometimes in conjunction with the seeds of "Rivea corymbosa", another species which has a similar chemical composition, with lysergol instead of ergometrine. Ergine was assayed for human activity by Albert Hofmann in self-trials in 1947, well before it was known to be a natural compound. Intramuscular administration of a 500 microgram dose led to a tired, dreamy state, with an inability to maintain clear thoughts. After a short period of sleep the effects were gone, and normal baseline was recovered within five hours. In 1956, the Central Intelligence Agency conducted research on the psychedelic properties of the ergine in the seeds of "Rivea corymbosa", as Subproject 22 of MKULTRA. In 1959, Hofmann was the first to isolated chemically pure ergine from the seeds of Turbina corymbosa, determining that it, and other alkaloids, were acting as the main active components in the seeds. 20 years prior to its isolation, ergine was first chemically defined by English chemists S. Smith and G. M. Timmis as the cleavage product of ergot alkaloids.