In October 2014, it was announced that she was to become Priest-in-Charge of St Mary-at-Hill, City of London. She moved to her new parish in November 2014, while maintaining her additional appointments. Since November 2014, she was Priest-in-Charge of St Mary-at-Hill, City of London until late 2019, additionally holding the role of Chaplain to the Speaker of the House of Commons, as well as Priest Vicar at Westminster Abbey and a Chaplain to the Queen. She was previously Vicar of Holy Trinity Church, Dalston and All Saints Church, Haggerston. In 2012, she was tipped as likely to be one of the first women to become bishops in the Church of England. On 28 June 2019 she was announced as the next Bishop of Dover, to run the Diocese of Canterbury on behalf of the Archbishop of Canterbury. On 19 May 2018, she was one of several religious leaders to lead prayers at the wedding of Prince Harry and Meghan Markle. On 28 June 2019, it was announced that Hudson-Wilkin was to become Bishop suffragan of Dover. As Suffragan, the Bishop of Dover has authority delegated by the Archbishop of Canterbury to oversee the diocese of Canterbury as if the diocesan bishop; she took up her see immediately before her consecration, which was scheduled for 19 November 2019 at St Paul's Cathedral. Press coverage of the announcement noted that she would be the first black woman to become a Church of England bishop; Guli Francis-Dehqani was the first ethnic minority woman to become a bishop, in 2017. On 19 November 2019, Hudson-Wilkin was consecrated a bishop by Archbishop Justin Welby at St Paul's Cathedral. She was installed as Bishop of Dover during a service at Canterbury Cathedral on 30 November 2019. Hudson-Wilkin was appointed Member of the Order of the British Empire (MBE) in the 2020 New Year Honours for "services to young people and the Church". She was also listed in the 2020 Powerlist, of the 100 the most influential people in the UK of African/African-Caribbean descent. After taking up her parish role in Hackney, Hudson-Wilkin staged a rooftop protest on the church with her curate to highlight the need for funds to repair the fabric of the building. Speaking on "Desert Island Discs" in January 2014, she said that with so much development going on in Hackney, she was trying to draw attention to the plight of the church, which had a leaking roof, adding that she wished she could have stayed a little longer on the roof as the protest attracted donations for its repair.