MSU's Larry Caper ended the game with a 23-yard TD run on 3rd down and 12, breaking three Michigan tackles that would have forced the Spartans to kick a field goal for the win. The Spartans outgained the Wolverines 417 to 251 in total yards and won the rushing battle 197 to 28. It is the 37th time in the last 40 meetings that the team who has won the rushing battle won the game. Michigan State won by six points: the last six meetings between the two teams in East Lansing have been decided by seven points or less, or a difference of 25 points in all six games combined. Week 6 brought the Wolverines to Iowa City, Iowa for a primetime duel against the Iowa Hawkeyes. Michigan went up early in the 1st with an interception that was returned 40 yards by Donovan Warren for a touchdown. Iowa responded a few minutes later with a 34-yard TD pass to Tony Moeaki from Ricky Stanzi and took the lead with a 28-yard Daniel Murray field goal soon after. Michigan responded late in the quarter when Brandon Minor ran for a touchdown from 3 yards. Iowa added 10 more points in the 2nd quarter: first a 41-yard field goal, then a 1-yard TD run by Brandon Wegher, making the halftime score 20–14 Iowa. The Hawkeyes opened the third quarter by booting a 40-yard field goal. Michigan responded with a 1-yard TD run late in the 3rd by Minor. Stanzi and Moeaki connected again for a 42-yard Iowa TD in the 4th. Michigan scored on a 3-yard TD run by QB Denard Robinson with about 4 minutes left and held Iowa to a 3-play drive, getting the ball back just down by 2 points (28–30). In the final minute of the game, Michigan drove down the field about 30 yards on an attempted drive to kick a game-winning field goal or TD, but Robinson threw a deep interception, sealing the Hawkeyes' victory. Michigan turned the ball over five times and fell to 1–5 in Big Ten road games under Rich Rodriguez. Michigan QB Tate Forcier left the game with 7 minutes remaining in the fourth quarter; it was later discovered that he sustained a concussion during the game. Backup quarterback Denard Robinson served as an able replacement, leading the Wolverines on the TD drive to bring them to within 2 until he threw the game-losing interception on the final drive. In week 7, Michigan hosted the from Division-I FCS, in the first ever meeting between the two teams.