Mesoamerica is a region and cultural area in the Americas, extending approximately from central Mexico to Honduras and Nicaragua, within which a number of pre-Columbian societies flourished before the Spanish colonization of the Americas in the 15th and 16th centuries. Prehistoric groups in this area are characterized by agricultural villages and large ceremonial and politico-religious capitals This culture area included some of the most complex and advanced cultures of the Americas, including the Olmec, Teotihuacan, the Maya, and the Aztec. Molecular genetics study suggests that "surviving" Amerindian populations derived from a theoretical single founding population, possibly from only 50 to 70 genetic contributors Preliminary research, restricted to only 9 genomic regions (or loci) have shown a genetic link between original Americas and Asia populations. The study does not address the question of separate migrations for these groups, and excludes other DNA data-sets. The American Journal of Human Genetics released an article in 2007 stating "Here we show, by using 86 complete mitochondrial genomes, that all Indigenous American haplogroups, including Haplogroup X (mtDNA), were part of a single founding population." Amerindian groups in the Bering Strait region exhibit perhaps the strongest DNA or mitochondrial DNA relations to Siberian peoples. The genetic diversity of Amerindian indigenous groups increase with distance from the assumed entry point into the Americas. Certain genetic diversity patterns from West to East suggest at least some coastal migration events. Geneticists have variously estimated that peoples of Asia and the Americas were part of the same population from 42,000 to 21,000 years ago.