Nola came in third in the voting for the NL Cy Young Award, behind Jacob deGrom and Max Scherzer. He came in 13th in the voting for National League Most Valuable Player. On February 13, 2019, Nola signed a four-year, $45 million extension with the Phillies. The deal includes a club option for a fifth year that's worth $16 million, with a $4.25 million buyout. For the second consecutive season, Nola started for the Phillies on Opening Day, earning the win in a 10–4 defeat of the Atlanta Braves. In 2019 Nola was 12–7 with a 3.87 ERA in a league-leading 34 starts. In innings (4th in the National League), he struck out 229 batters (7th; 10.2 per 9 innings) and hit 11 batters (3rd). He also faced a league-leading 852 batters. On defense, he shared the league lead among pitchers with a 1.000 fielding percentage.