Part of State Route 80 between Van Hornesville and Starkville was entirely washed out. Large amounts of sediment were also carried downstream and deposited which caused flooding to be worse. One fatality was reported in this storm. In February 2017, 625 residents were told to evacuate as the flood warning siren was activated because of quickly rising waters. After a short time residents were told it was safe to go home. No major damage occurred during this flood, only a few trees and wires were knocked down and minor stream bank erosion occurred. Fish species present in the creek are brook trout, brown trout and rainbow trout. In 2019 there were 270 brown trout released into the creek in the Town of Minden, and 350 brown trout and 1000 rainbow trout in the Town of Stark. In 2015, Dominion energy proposed to expand the compressor station at Brookmans Corners, located near the banks of the creek. Concers were brought up about the pollution that would be caused, at an estimated 96,683 tons of greenhouse gas emissions would be put into the air every year. These concerns are compounded by Otsquago Creek and the particular topography of the Otsquago valley that limits the dispersion of emissions. The Robert B. Woodruff Outdoor Learning Center was built and opened in the summer of 1984 and consists of within the Otsquago gorge. It is located at the site of an 18th century trail, which became the road between Fort Plain and Cooperstown in the 19th century. After the trails were built in 1984, it provided better access to the numerous waterfalls in the gorge as well as the limestone caves. The Young family partnered with Otsego Land Trust to conserve about bordering the creek by Van Hornesville, to preotect the village's water supply. Another was later donated as well to further protect the community's water supply.