Larry Welch was alive and was now blackmailing Colin to kill his own cousin, Bo. Later Jennifer was spying on a meeting between André and Colin where they discussed how to enhance the DiMera empire. When André and Colin left the room she tried to get out but Colin caught her. She was forced to sleep with him in order to keep her cover. Later on, she told to Bo and Jack what she discovered. When Jennifer and Jack were getting together again, Colin wanted Sami to lure Jack out so he could kill him. Instead, Sami told André. At the night of Victor's wedding, Colin was ordered by Larry Welch to kill Bo Brady. When Colin was waiting outside and aiming at Bo, Shawn-Douglas Brady saw him and began fighting Colin. The gun accidentally went off, injuring Colin. Colin escaped, but not far. He ran into Nicole, who told him she would kill him if he did not stop blackmailing her. When he made an attempt to get the gun away from Nicole but it fired and killed him. The body was later found by Belle Black. Nobody knew who killed Colin. Not long after the event transpired, his ghost started haunting several of the suspects of his murder. Victor found out it was Nicole and that Colin was blackmailing her with the tape. Later, Nicole and Brady Black went to Melaswen, a.k.a. New Salem, in order to prove Nicole was innocent. They found Colin Murphy was alive but being held captive and tortured by Bart Beiderbecke and André DiMera. They rescued him and found the rest of the prisoners. Colin told them that this was all planned years in advance, even before André entered Salem. He said everyone who was killed was actually being drugged and pronounced dead by a doctor working for the DiMeras at the hospital. He also said that André wanted him to be the doctor on the inside, but when Colin refused, André drugged and "murdered" him like the rest. Colin told Nicole and Brady he would give the names of everyone involved when they got back to Salem but when they were about to escape, André and his men arrived and dragged Colin away. Colin was the only casualty of the Melaswen storyline. While leaving the island during a storm, he was lost at sea and assumed to have drowned.