These bacteria are involved in different types of infections, the severity of which depends on the immune status of the patient. In the literature, cases were reported in immunocompromised and immunocompetent patients. In immunocompetent patients, these bacteria belong to the oral bacterial community responsible for periodontal infections affecting and destroying the supporting tissues of teeth (periodontal tissue). "Capnocytophaga" strains are often isolated from periodontal pockets, but also from apical and periodontal abscesses, in association with other bacterial parodontal species. This condition increase alveolar bone loss, attachment loss, tooth mobility, and finally tooth loss. It can cause other diseases widely reported in the literature, such as bacteremia (potentially complicated by septic shock), infections of the musculoskeletal system (osteomyelitis, arthritis), lung (empyema, lung abscess), digestive (peritonitis), maternal-fetal (ovarian abscess, chorioamnionitis), eye (conjunctivitis), heart (endocartitis) or brain (meningitis). "Capnocytophaga" is clinically important in pediatric oncology and hematology, especially when patients are in aplasia. "C. canimorsus" and "C. cynodegmi" are commonly transmitted by dog bites and known to cause sepsis, potentially complicated by thrombotic thrombocytopenic purpura and hemolytic uremic syndrome, in immunocompromised patients. "Capnocytophaga" spp. are usually susceptible to antibiotics, but the emergence of beta-lactam-resistant strains has been observed as early as 1980. Genes for antibiotic resistance have gradually spread among other pathogenic bacterial species by horizontal gene transfer. Susceptibility to various beta-lactam antibiotics has been described as variable depending on the strain of "Capnocytophaga". This resistance is often linked to the production of beta- lactamases. Most beta-lactamases identified in "Bacteroides", "Prevotella", and "Capnocytophaga" belong to the Ambler class A. Several beta-lactamases encoded by the chromosome or a plasmid and associated with mobile genetic elements have been described in "Capnocytophaga" spp. The most common are: "CfxA, CfxA2, CepA, CblA", and/or "CSP-1".