A first victory of the campaign was secured on 24 September against Macclesfield Town. Warren Feeney and Robbie Williams scored either side of half time to give Argyle a 2–0 win at Home Park. October began with a 2–0 defeat at Crawley Town. Striker Matt Tubbs scored both goals for the home side. Jamie Griffiths' loan from Ipswich Town was extended for a further month. The team threw away a two-goal lead to draw 2–2 with ten-man Accrington Stanley on 8 October. Simon Walton and Ladjie Soukouna scored before half-time after Sean Hessey was sent-off. Despite that, Accrington came back to earn a point thanks to goals from Kevin Long and Pádraig Amond. Argyle claimed their first away win of the season a week later at Dagenham & Redbridge. Matt Lecointe and Conor Hourihane gave the club a two-goal lead before Scott Doe and Jon Nurse scored for Dagenham. Simon Walton converted a stoppage time penalty to give Argyle a 3–2 victory. A late goal from Raffaele De Vita gave Swindon Town a 1–0 win at Home Park on 22 October. A 5–1 defeat at Oxford United three days later was their eleventh of the season. Robert Hall and James Constable both scored twice, with Peter Leven scoring Oxford's third. Argyle were briefly level in the second half after Simon Walton converted a penalty. Jamie Griffiths was sent off as Argyle lost 2–1 at Cheltenham Town on 29 October. An effort on goal by Jared Sims was turned in by Cheltenham defender Steve Elliott and Argyle retained the lead for an hour before Darryl Duffy scored from the penalty spot. Griffiths was sent off two minutes later and then Duffy scored the winner in stoppage time. Having guided Argyle to two wins and a draw since the departure of Peter Reid, new owner James Brent appointed Carl Fletcher as the club's player-manager on a full-time basis. Defender Ben Gibson's loan from Middlesbrough was extended until 29 January. Blackpool defender Paul Bignot joined the club on loan for three months on 4 November. An injury-time equaliser from Nick Fenton denied Argyle their third league win of the season as they drew 1–1 with Morecambe. Simon Walton gave the home side the lead in the first half and looked like picking up three much-needed points before Fenton's equaliser in the 94th minute.