Their pathogenicity partly results from their ability to produce capsular polysaccharide, which is protective against phagocytosis and stimulates abscess formation. "B. fragilis" is involved in 90% of anaerobic peritoneal infections. It also causes bacteremia associated with intra-abdominal infections, peritonitis and abscesses following rupture of viscus, and subcutaneous abscesses or burns near the anus. Though it is gram negative, it has an altered LPS and does not cause endotoxic shock. In general, "B. fragilis" is susceptible to metronidazole, carbapenems, tigecycline, beta-lactam/beta-lactamase inhibitor combinations (e.g., Unasyn, Zosyn), and certain antimicrobials of the cephalosporin class, including cefoxitin. The bacteria have inherent high-level resistance to penicillin. Production of beta lactamase appears to be the main mechanism of antibiotic resistance in "B. fragilis". Clindamycin is no longer recommended as the first-line agent for "B. fragilis" due to emerging high-level resistance (>30% in some reports). "B. fragilis" bacteriophages are commonly used as tracers of human faecal material. Otl Aicher  Otto "Otl" Aicher (13 May 1922 – 1 September 1991) was a German graphic designer and typographer. He is best known for having designed pictograms for the 1972 Summer Olympics in Munich that proved influential on the use of stick figures for public signage, as well as designing the typeface Rotis. Aicher also co-founded the Ulm School of Design. Aicher was born in Ulm, in the south-western state of Baden-Württemberg, on 13 May 1922. Aicher was a classmate and friend of Werner Scholl, and through him met Werner's family, including his siblings Hans and Sophie Scholl, both of whom would be executed in 1943 for their membership in the White Rose resistance movement in Nazi Germany. Like the Scholls, Aicher was strongly opposed to the Nazi movement. He was arrested in 1937 for refusing to join the Hitler Youth, and consequently he was failed on his abitur (college entrance) examination in 1941. He was subsequently drafted into the German army to fight in World War II, though he tried to leave at various times.