On 16 July 2011, Márquez made his comeback in Cancún on the same card as his brother, Juan Manuel, against Eduardo Becerril. Both fights were tune-ups and the younger Márquez brother comfortably dealt with his opponent, knocking him down once on the way to a 6th-round TKO. Márquez fought against WBC Super Bantamweight champion Toshiaki Nishioka on 1 October at the MGM Grand Garden Arena in Las Vegas. Marquez lost by unanimous decision. He was recently in a car accident in Cuernavaca, Mexico. He was on his way to the airport in Mexico City to go to New York to receive the award for fight of the year, where he fought Israel Vázquez. He made his appearance on Fight Night Round 2 launched in 2005.