Upon taking office, Comrie was appointed Ranking Member on the Elections Committee and Consumer Protection Committee. Comrie was also selected to be a delegate at the 2016 Democratic National Convention for the New York State 5th Congressional District. Following the election of President Trump, Comrie joined Democrats across the State of New York to call for the Independent Democratic Conference of 8 State Senators to stop supporting the Republican Conference. He even began to vocally protest the institution by participating in town halls organized by their opponents. At one of these town halls, Comrie called his colleague, the Northeast Queens Senator Tony Avella, "the single most selfish person that I've ever met on a lot of different levels ... He has not reached out to me at all in any type of collegial fashion." During his first legislative session in the New York State Senate, Leroy Comrie also passed a bill that expanded access to rent stabilization for the disabled. As state senator, Comrie has helped lead the community on multiple initiatives such as preventing a state-run juvenile prison from being built on a closed elementary school in Queens Village, fighting the development of a multi-story religious dormitory on the controversial Chabad Lubavitch Jewish synagogue in Cambria Heights/Laurelton, and stopping the closure of the EmblemHealth facility in Cambria Heights which provides medical education and programming to the surrounding community. Comrie also took several high-profile stances against legislation considered by the NYC Council such as working with other Queens elected officials in opposing the congestion pricing proposal, and, in the NYS Senate, repealing the plastic bag fee passed by the NYC Council  As Ranking Member on the Elections Committee, he has pushed for the Vote Better NY legislation package to address "the catastrophe known as New York's election law" by establishing early voting, simplifying ballots, and streamlining voter registration. The bills, among others, has stalled in the New York State Senate due to opposition by the Republican leadership in control of the chamber. Comrie introduced legislation that would allow absentee ballot voting without an excuse. It would require amending the state constitution. In 2007, Leroy Comrie was tangentially associated with a controversy regarding the dismissal of Council Member Charles Barron's chief of staff, Viola Plummer. Following a heated committee meeting on a bill co-naming a street in Brooklyn after Robert "Sonny" Carson, Plummer exited city hall and spoke to a small group in the plaza that included reporters. Plummer, a resident of Comrie's district, threatened to end Comrie's career and politically "assassinate" Comrie.