Nutty Professor II: The Klumps  Nutty Professor II: The Klumps is a 2000 American science-fiction romantic-comedy film directed by Peter Segal. It is a sequel to the 1996 film "The Nutty Professor". In contrast to the previous film, subplots which are centered on his parents (with his brother and grandmother providing comic relief) occupy a substantial part of the film. Like the first film, the sequel's theme song is "Macho Man" by The Village People, which this time is played during the end credits. Sherman Klump has created a new youth formula which enables those who take it to de-age. He has also fallen in love with a colleague, Denise Gaines, who has developed a method to isolate genetic material. Despite his good fortune, Sherman has a major problem: the personality of his alter ego Buddy Love is still ingrained inside him and has begun to periodically take control of his body. Sherman tries proposing to Denise, but Buddy takes over and humiliates him, mortifying Denise. Determined to be rid of Buddy permanently, and despite his assistant Jason warning him of potentially consequences for his health, Sherman uses Denise's methodology to isolate and remove a gene in his DNA where Buddy has manifested. However, the genetic material containing Buddy grows into a sentient being when a hair from a Basset Hound accidentally lands in it. Sherman apologizes to Denise and the two become engaged. Later, Dean Richmond informs the two that a pharmaceutical firm has offered Wellman College $150 million for the youth formula. Sherman and Denise then encounter the newly reformed Buddy at a movie theater. Buddy pickpockets Sherman and learns of the $150 million offer. He subsequently visits the pharmaceutical company and makes a rival bid for the youth formula. Sherman learns that due to the extraction, his body chemistry has been altered and that he is losing his intelligence. Realizing he needs to keep the youth formula out of Buddy's hands, Sherman stashes it at his parents' house. Sherman's father Cletus, who is sexually frustrated due to his age and impotence, drinks some of the youth formula. He goes out for a night on the town and attempts to seduce his wife, but she is horrified. Buddy love witnesses Cletus changing and realizes that the youth formula is being stored in the Klump household. Meanwhile, Sherman's condition causes him to act like a fool in front of Denise's parents, concerning her. Buddy steals some of the youth formula from the Klump household, and fills the vial the rest of the way with fertilizer.