Keokuk, Iowa  Keokuk is a city in and a county seat of Lee County, Iowa, United States, along with Fort Madison. It is Iowa's southernmost city. The population was 10,780 at the 2010 census. The city is named after the Sauk chief Keokuk, who is thought to be buried in Rand Park. It is in the extreme southeast corner of Iowa, where the Des Moines River meets the Mississippi. It is at the junction of U.S. Routes 61, 136 and 218. Just across the rivers are the towns of Hamilton and Warsaw, Illinois, and Alexandria, Missouri. Keokuk, along with the city of Fort Madison, is a principal city of the Fort Madison-Keokuk micropolitan area, which includes all of Lee County, Iowa, Hancock County, Illinois and Clark County, Missouri. Situated between the Des Moines and Mississippi rivers, the area that became Keokuk had access to a large trading area and was an ideal location for settlers. In 1820, the US Army prohibited soldiers stationed along the Mississippi River from having wives who were Native American. Samuel C. Muir, a surgeon stationed at Fort Edwards (near present-day Warsaw, Illinois), instead resigned his commission rather than leave his Indian wife and crossed the river to resettle. He built a log cabin for them at the bottom of the bluff, and became the area's first white settler. As steamboat traffic on the Mississippi increased, more European Americans began to settle here. Around 1827, John Jacob Astor established a post of his American Fur Company at the foot of the bluff. Five buildings were erected to house workers and the business. This area became known as the "Rat Row." One of the earliest descriptions of Keokuk was by Caleb Atwater in 1829:  The settlement was part of the land designated in 1824 as a Half-Breed Tract by the United States Government for allotting land to mixed-race descendants of the Sauk and Fox tribes. Typically children of European or British men (fur traders and trappers) and Native women, they were often excluded from tribal communal lands because their fathers were not tribal members. Native Americans considered the settlement a neutral ground. Rules for the tract prohibited individual sale of the land, but the US Congress ended this provision in 1837, creating a land rush and instability. Centering on the riverboat trade, the settlement continued to grow. The village became known as Keokuk shortly after the Blackhawk War in 1832.