Ponce de Leon, Florida  Ponce de Leon ( ) is a town in Holmes County, Florida, United States. The population was 598 at the 2010 census, up from 457 at the 2000 census. From 2000 to 2010, the Ponce de Leon town population growth percentage was 30.9%. Ponce de Leon is located in southwestern Holmes County at (30.725783, -85.937783). U.S. Route 90 runs through the center of town, leading northeast to Bonifay, the Holmes County seat, and west to DeFuniak Springs. Florida State Road 81 crosses US 90 near the center of town, leading north to the Alabama border and south to Florida State Road 20 at Bruce. Interstate 10 passes through the southern part of Ponce de Leon, with access from Exit 96 (SR 81). I-10 leads east to Tallahassee and west to Pensacola. According to the United States Census Bureau, the town has a total area of , of which are land and , or 0.78%, are water. The town is in the valley of Sandy Creek, a south-flowing tributary of the Choctawhatchee River. Ponce de Leon Springs State Park is in the southern part of the town, north of I-10, along both sides of Sandy Creek. The entrance is on the eastern side of the park off Ponce de Leon Springs Road. As of the census of 2010, there were 598 people, 246 households, and 131 families residing in the town. The population density was 92.3 people per square mile (35.6/km²). There were 290 housing units at n average density of 47.0 per square mile (18.2/km²). The racial makeup of the town was 91.60% White, 1.80% African American, 2.41% Native American, 1.00% from other races, and 2.00% from two or more races. Hispanic or Latino of any race were 3.00% of the population. There were 200 households out of which 30.0% had children under the age of 18 living with them, 48.5% were married couples living together, 11.5% had a female householder with no husband present, and 34.5% were non-families. 29.5% of all households were made up of individuals and 14.5% had someone living alone who was 65 years of age or older. The average household size was 2.29 and the average family size was 2.82.