In 2006, Khalifé performed at the University of Michigan's Hill Auditorium as part of the Arab World Music Summit. In 2007, Khalifé released a record called "Piano Concertos" which was Piano Concerto No. 5 by Sergei Prokofiev and Piano Concerto No. 1 by Lebanese-Russian composer Abdalla El-Masri. In 2013, Khalifé performed original music inspired by the Arab Spring called "Requiem for Beirut" at the Qatar Philharmonic Orchestra and the MDR Leipzig Radio Choir. In 2015, he performed the work at an outdoor concert at Martyrs' Square in Beirut. In 2016, Khalifé performed his composition "Stories" for piano and orchestra with the Chamber Orchestra of Philadelphia. In May 2017, he performed his work, "Voyage with Marcel Khalifé" at the Philharmonie de Paris with his father and at the Orchestre national d'Île-de-France, conducted by Julien Leroy. In 2018, Khalifé released his fifth solo record, an almost completely instrumental work called "Lost". In 2005, Khalifé founded the classic electronic group Aufgang, initially as a modern experimental music piano duo with Francesco Schlimé aided by digitized music. Aufgang then became a three person project with Khalifé, Francesco Tristano, and Aymeric Westrich, with a record deal with the French label InFiné. They broke out at the 2005 Sonar Festival in Barcelona. In 2011, Khalifé began a new project with his father and brother called "Marcel, Rami & Bachar Khalifé". They debuted at the Beirut Music & Art Festival and was broadcast on MTV. The group was made up of Marcel Khalifé on oud with son Rami Khalifé on piano and son Bachar Khalifé on percussion – with Gilbert Yammine on qanun. In 2016, the group released a collaborative record called "Andalusia of Love", a mixture of traditional music inspired by the Palestinian writer Mahmoud Darwish and improvised compositions from Rami and Bachar. They toured the United States under the sponsorship of American-Arab Anti-Discrimination Committee, making their United States debut at Town Hall in New York City. Khalifé lives in Paris with his wife, ABC Broadcast Journalist Mariam Saab and their two children.