U.S. Route 52 in South Carolina  U.S. Route 52 (US 52) is a north–south U.S. Highway that travels from Charleston to the North Carolina state line near Cheraw. It serves as a strategic highway through the central part of the state. Though an even-numbered U.S. Highway, which are typically signed east–west, it is signed north–south in South Carolina. In some other states along its route, it is signed east–west. The South Carolina segment is signed such that U.S. 52 north corresponds to the general westward direction of the highway, and vice versa. US 52 begins at the intersection of Meeting and Line Streets, in Charleston. Going northwest along Meeting Street, it connects with I-26/US 17, followed by Morrison Drive (US 52 Spur hidden); US 52 signage begin to appear north of Morrison Drive. In North Charleston, it is concurrent with US 78 for , splitting near Goose Creek. From Moncks Corner, US 52 is briefly concurrent with US 17 Alt as it enters the Francis Marion National Forest and crosses the Dennis C. Bishop Bridge over the Tail Race Canal of the Cooper River just below Lake Moultrie. The route traverses the Francis Marion National Forest as it oontinues northward to St. Stephen. From there is proceeds to Kingstree and Lake City, before another short concurrency with US 301 from Effingham to Florence. Through downtown Florence, it goes northwest and bypasses Darlington and joining another concurrency with US 401. At Society Hill, it merges briefly with US 15 before continuing north again solo to Cheraw, where it overlaps briefly with US 1 and SC 9. US 52 crosses the North Carolina state line, after traveling through South Carolina, continuing on towards Wadesboro. US 52 is a major highway between Charleston and Florence, all of which is four-lane or more with some sections signed . North of Darlington, it becomes mostly a two-lane rural highway through the remainder of its route. Though the majority of its routing and signage is north-south, some sections will also be signed east-west at various parts of the state. US 52 in South Carolina feature a few dedicated or memorialized stretches of freeway. US 52 was established in 1935 as a renumbering of US 601 from the North Carolina state line to Florence and US 17 from Florence to Charleston. In 1939, US 52 was rerouted into a concurrency with US 78 in North Charleston, leaving a section of Meeting Street.