From 2003 through 2007 Jorgensen served as editor-in-chief of "The Plant Cell", a research journal in plant biology. From 2007 to 2009 he was director of the iPlant Collaborative, a 5-year, $50 million project to develop cyberinfrastructure for the plant sciences. According to the US National Science Foundation (NSF) awarding agency, this was "the first national cyberinfrastructure center to tackle global "grand challenge" plant biology questions that have great implications on larger questions regarding the environment, agriculture, energy and the very organisms that sustain our existence on earth". Researchers relied heavily on computational thinking, which uses computers to free up humans to spend more time on the creative tasks that humans do best. Jorgensen became professor investigador at LANGEBIO (Laboratorio Nacional de Genomica para la Biodiversidad), a new research institute in the Mexican federal CINVESTAV research system located in Irapuato, Guanajuato, Mexico. He retained a title as professor emeritus in the School of Plant Sciences at the University of Arizona. His research interests are in computational biology.