In 1997 Frahm become Adjunct Professor at the Faculty for Chemistry of the Georg-August-University in Göttingen. Since 2011 he is an External Member of the Max Planck Institute for Dynamics and Self-Organization. Central to the research of Frahm is the further methodologic development of MRI and localized magnetic resonance spectroscopy (MRS) in conjunction with advanced applications in neurobiology (brain research) and cardiovascular research. The truly interdisciplinary team aims at innovative noninvasive approaches to study the central nervous system of humans and animals - from insects to primates with a special emphasis on mouse models of human brain disorders. Using several high-field MRI systems, current possibilities include structural, metabolic, and functional assessments of the intact living brain. Techniques range from high-resolution 3D MRI studies of brain morphology and localized proton MRS of brain metabolism to fiber tractography of the axonal connectivity via diffusion tensor imaging and mapping of the functional architecture of cortical networks by functional MRI. Current methodologic projects focus on the use of iterative image reconstruction techniques for non-cartesian MRI (e.g., undersampled radial MRI) and parallel MRI that define the reconstruction process as a nonlinear inverse problem. Other developments address the possibility of real-time MRI in order to overcome the motion sensitivity of conventional MRI acquisitions and to monitor organ movements in real time. Most recent achievements in real-time MRI are based on FLASH techniques with highly undersampled radial data encodings. When combined with image reconstruction by nonlinear inversion with temporal regularization, they allow for movies of the human heart with image acquisition times as short as 10 to 30 milliseconds, which correspond to MRI movies with up to 100 frames per second. Such real-time movies may continuously be recorded during free breathing, without ECG synchronization, and without motion artifacts. Apart from cardiac applications and quantitative measurements of blood flow in real time, novel possibilities range from studies of joint movements, bowel motility and swallowing mechanics (e.g., dysphagia and reflux disorders) to speech generation and brass playing. Interactive real-time MRI will also revitalize "interventional" MRI which refers to MRI monitoring of minimally invasive procedures. A selection of example MRI videos can be found here: Biomedizinische NMR. The development of a high-quality and robust real-time MRI technique must be considered another breakthrough in MRI that promises to shape its future. Real-time MRI will again broaden the diagnostic potential of MRI by adding completely new, hitherto impossible scientific and clinical applications as well as by simplifying and shortening existing procedures.