In early 2006, she was signed to American lingerie brand Victoria's Secret, making her début at the brand's fashion show in Los Angeles. Huntington-Whiteley remained unknown outside the fashion industry until 2008, when she was cast by chief creative director Christopher Bailey, replacing Agyness Deyn for Burberry's autumn/winter campaign with actor Sam Riley. She got her first "British Vogue" cover on the November 2008 issue, alongside Eden Clark and Jourdan Dunn in a feature celebrating British models. The following year, she was featured as the face of Karen Millen's spring/summer 2009 advertising campaign. She starred in a short film for Agent Provocateur lingerie playing a woman whose boyfriend forgets Valentine's Day. For fall/winter 2009, she modelled in campaigns for Godiva and Miss Sixty. In February 2010, Huntington-Whiteley officially became a Victoria's Secret Angel modelling for the Victoria's Secret Fashion Show in New York City. In 2010, she posed nude for the Pirelli Calendar, which was photographed by Terry Richardson. Huntington-Whiteley hit the runway for designers Prada in Milan and Giles Deacon in Paris. For SS10 her advertising campaigns included Monsoon's first underwear line, Thomas Wylde, Full Circle, and VS Online. In March, she collaborated with VOGUE.COM to share her outfit choices daily for the "Today I'm Wearing" feature. She appeared on the covers of the May 2010 issues of "Harper's Bazaar" Russia and "GQ" UK. She was featured on the cover of "LOVE" Magazine's September issue, styled as a pinup girl. For FW10 she modelled for Burberry as well as the company's first Beauty line; her other advertising campaigns included Thomas Wylde and Leon Max. Fashion photographer Rankin devoted a book entirely to her entitled "Ten Times Rosie". Rankin opined that Huntington-Whiteley brought something different to modelling: "We’ve been looking at very, very skinny, almost masculine girls for a long time. [Rosie] really is the model of the moment. She’s the actress of the moment. She’s definitely going to become something much, much bigger." Celebrity make-up artist Ruby Hammer, who has worked with Huntington-Whiteley for years, described her as the "quintessential" . In March 2011, Huntington-Whiteley landed her first solo "British Vogue" cover and appeared on the covers of the UK's July issues of "Elle" and "GQ".