While in Blondie, Stein and Harry maintained a romantic relationship but never married. In 1989, the couple went their separate ways but have continued to work together on a professional basis. Stein was co-host of "TV Party", a public-access television cable TV show in New York City, that ran from 1978 to 1982. In 1983, Stein was diagnosed with pemphigus vulgaris, a rare autoimmune disease of the skin, but he has since regained normal function. Stein had developed a mild form of the disease, and was able to control it with a program of steroids. As of 2016, he was still touring and recording with Blondie. In 1999, Stein married the actress Barbara Sicuranza, and they have two daughters, Akira and Valentina.