In 2007, Jeffers was the official World Book Day Illustrator. "Lost and Found" became Jeffers' first book to be made into animation by London-based Studio AKA, premiering on Christmas Eve 2008 on Channel 4. In Australia it aired on Christmas Eve 2009 on ABC1 and Christmas Day 2009 on ABC3. Lost and Found the animation has won more than 40 international awards, including a BAFTA for Best animation in 2009. In 2008, Jeffers featured in "The Times" list of "The Best New Picture Book Illustrators". In 2010, The Heart In the Bottle was released as an iPad app, by Harper Collins. In 2012, Jeffers provided illustrations for the UK Kinder TV ad campaign. In 2013, Jeffers illustrated the vinyl cover (a drawing of Nelson Mandela) for the U2 song "Ordinary Love". Jeffers also co-directed (with Mac Premo) the video for the U2 song "Ordinary Love". Two years later, Jeffers contributed video content to the band's Innocence + Experience Tour, creating the chalk drawings and collages for the "innocence" act of the show. In 2017, Jeffers wrote and illustrated "Here We Are: Notes for Living on Planet Earth", a children's book which topped the New York Times Bestseller list in its debut and won "Time" Magazine's 2017 Best Book of the Year award in the Young Adult and Children's Books category. In 2020, Jeffers delivered a TED Talk, ‘Ode to Living on Earth’, which was released on Earth Day.