The route was designated in 1958, after the mainline was moved onto the Shenango Valley Freeway (which is not a true freeway, but instead features at-grade intersections). For its first mile, the route is cosigned with other highways, first Pennsylvania Route 718, then Pennsylvania Route 518. Soon afterward, it expands to four-lanes and contains the hub of commercial development for the region. U.S. Route 62 Business follows Pine Avenue through downtown Niagara Falls, New York, spanning between NY 104 at its western terminus and US 62 at its eastern extent. Although it runs in a mostly east–west direction, it is signed as a north–south route due to US 62 being signed north–south as well within New York. Pine Avenue was originally designated as part of NY 34 in the 1920s. It then became part of NY 18 after it replaced NY 34 in 1930. In 1932, US 62 was extended into New York and overlapped NY 18 between Dayton and Niagara Falls. NY 18 was truncated to Lewiston, a village north of the city, in the early 1960s, making US 62 the sole occupant of Pine Avenue. US 62 was shifted onto its current alignment through the city later in the decade, allowing Pine Avenue to become New York State Route 62A in the 1970s. NY 62A was redesignated as US 62 Business in 2006.