In the aftermath of his loss to the aforementioned Cotto, Mayorga went on record to state that he doesn't entirely dismiss the possibility of a comeback. Sources close to him predicted that he would return to the sport to face Antonio Margarito in a bout that would've supposedly been dubbed: "When villains collide", with the winner earning themselves one final shot at being able to resurrect their career and the loser permanently retiring from boxing – a fight that would've entertained fans not only at a press conference, but also inside the ring as well.