Yet Best's film roles are not limited to Westerns. He also stars in the 1959 science fiction cult movie "The Killer Shrews" and in its 2012 sequel "Return of the Killer Shrews", as Rhidges in the 1958 film adaptation of Norman Mailer's "The Naked and the Dead", as Carter in the James Stewart classic "Shenandoah", as Dr. Ben Mizer in the 1966 comedy "Three on a Couch", and as the cross-dressing Dewey Barksdale in the 1976 drama "Ode to Billy Joe". Best guest-starred more than 280 times in various television series. In 1954, he played the outlaw Dave Ridley, opposite Gloria Winters as the female bandit "Little Britches" in an episode of "Stories of the Century". In 1954, Best appeared twice on the syndicated "Annie Oakley" series, starring Gail Davis and Brad Johnson. In 1955, he played Jim Blake on "The Lone Ranger", Season 4, Episode 47, along with Clayton Moore & Jay Silverheels. He was cast in the religion anthology series "Crossroads", in its 1956 episode "The White Carnation." He was also cast on an episode of Jackie Cooper's early NBC sitcom "The People's Choice" and in the David Janssen crime drama "Richard Diamond, Private Detective". Best made four appearances on the syndicated anthology series, "Death Valley Days". His first role was as miner "Tiny" Stoker in the 1955 episode, "Million Dollar Wedding". In the story line, Stoker, in a bet with two of his cohorts, proposes marriage to a presumably plain woman in their community, Aggie Filene (played by Virginia Lee, an actress who lived from 1924 to 2008). Soon, though, the couple falls madly in love with each other and go on a world-wide honeymoon tour with proceeds from a gold strike that they had nearly forfeited. And Aggie returns to the mining camp as a beautiful woman. In 1960, Best appeared in the episode "Love on Credit" of CBS's anthology series, "The DuPont Show with June Allyson". The same year, he guest-starred on "The Andy Griffith Show" as "The Guitar Player" (Season 1, Episode 3 and 31). He starred in three episodes of "The Twilight Zone" including "The Grave" (Season 3, Episode 7), "The Last Rites of Jeff Myrtlebank," (Season 3, Episode 23) and "Jess-Belle" (Season 4, Episode 7).