Despite being granted the majority of the team's rushes, he had fewer yards than either Thompson (78) or Kelley (77). In Week 3 against the Oakland Raiders, he again led the team in carries with 19 but for only 49 yards, and was moved back into a supporting role. Perine collected just 59 rushing yards total in Weeks 4-9, though he did pick up his first career touchdown on a three-yard reception from Kirk Cousins against San Francisco in Week 6. After nine rushes for 35 yards and a 25-yard reception in Week 9, Perine moved back to starting following injuries to both Thompson and Kelley. He had success in Week 10 with 23 rushes for 117 yards, as well as his first career rushing touchdown against the New Orleans Saints, marking the first 100-yard rushing game for the Redskins of the season. He followed this up the following week with 24 rushes for 100 yards against the New York Giants, marking first Redskin with consecutive yard games of over 100 yards since Alfred Morris in 2013. Overall, he finished his rookie season with 603 rushing yards and one rushing touchdown to go along with 22 receptions for 182 yards and a receiving touchdown. In a backfield where new arrival Adrian Peterson recorded most of the carries, Perine had eight carries for 32 yards in five games in the 2018 season. Perine was waived prior to the 2019 regular season on August 31. On September 1, 2019, Perine was claimed off waivers by the Cincinnati Bengals. He was waived on October 17, 2019, but re-signed to the team's practice squad the following day. On December 24, 2019, Perine was signed by the Miami Dolphins off the Bengals practice squad. He was waived on April 26, 2020. On April 28, 2020, Perine was claimed off waivers by the Cincinnati Bengals. During his time in high school and Oklahoma, Perine was noted for his acts of great physical strength, such as helping lift a car to help a fellow student who did not have a car jack change a flat tire. Jerry Schmidt, strength coach of the Sooners, stated that he could often out bench press most of the team's lineman, with his max being 440 lbs. Schmidt also noted that nobody else on the team was able to top Perine's max squat (540 lbs), power clean (380 lbs), or incline bench (315 lbs) numbers. Perine's cousin, Lamical Perine, played running back for the Florida Gators and was drafted by the New York Jets in 2020.