She was defeated in the third round by qualifier Zhang Shuai. At the Dubai Tennis Championships, Lepchenko lost in the final round of qualifying to Zheng Saisai. In Qatar at the Qatar Total Open, Lepchenko was defeated in the first round by Zheng Saisai. Lepchenko then missed the next two months from tour citing a knee injury. Lepchenko returned to action in May at the Italian Open. She lost in the final round of qualifying to Kiki Bertens. Before the French Open, Lepchenko competed at the Nürnberger Versicherungscup. She advanced to the quarterfinal round by beating German wildcard Katharina Hobgarski and fifth seed Sabine Lisicki. She was defeated in her quarterfinal match by eventual finalist Mariana Duque Mariño. At the French Open, Lepchenko lost in the first round to twenty-seventh seed Ekaterina Makarova. Seeded second at the Bol Open, Lepchenko was defeated in the second round by eventual champion Mandy Minella. Lepchenko started her grass-court season at the Ricoh Open. She lost in the second round to top seed Belinda Bencic. At the Aegon Classic Birmingham, Lepchenko was defeated in the first round of qualifying by Laura Robson. Getting past qualifying in Eastbourne at the Aegon Classic Birmingham, Lepchenko lost in the first round to Eugenie Bouchard. At the Wimbledon Championships, Lepchenko was defeated in the second round by fourth seed and eventual finalist Angelique Kerber. Lepchenko started her preparation for the US Open at the Bank of the West Classic. Seeded eighth, she lost in the first round to Alison Riske. At the Rogers Cup, Lepchenko fell in the final round of qualifying to Alla Kudryavtseva. However, due to Garbiñe Muguruza pulling out of the tournament due to gastrointestinal illness, Lepchenko not only got a lucky loser spot into the main draw, but she also got a bye to the second round. She beat qualifier Naomi Broady in her second-round match; she was defeated in the third round by fifteenth seed Johanna Konta. In Cincinnati at the Western & Southern Open, Lepchenko lost in the first round of qualifying to Donna Vekić. At the Connecticut Open, Lepchenko was defeated in the second round of qualifying by Johanna Larsson. Playing in New York at the last Grand Slam of the year, the US Open, Lepchenko reached the third round after beating Peng Shuai and fifteenth seed Timea Bacsinszky.