Aquilina has received significant popularity in Malta since the release of her debut EP, "Fools". She has topped the Maltese iTunes chart, above Adele, and has been noted in several Maltese newspapers and websites and on Malta's National TV channel, TVM, as of October 2012. The title track from "Fools" received its first UK national radio play on BBC Radio 1 on 15 October 2012 on the "BBC Introducing" show. It was announced on 15 August 2013 that Aquilina would headline the BBC Introducing stage at Reading & Leeds Festival 2013. She also played her first ever show in the United States on 21 August 2013 when she played a sold-out headline show at Manhattan's Rockwood Hall. Aquilina released her final EP "Liars" in the "Fools, Sinners, Liars" EP trilogy on 10 March 2014. Having asked to hear Lauren's third EP "Liars," which she recorded and marketed with her manager, Island Records and Universal Music Group signed Aquilina as a new artist. In June 2014, Aquilina collaborated with Scottish band Prides on one of their tracks, "Strong Enough". As of October 2014, Aquilina's trilogy of EPs have sold over 100,000 copies between them. Aquilina also put on a mini-tour of three UK shows as a special thank you to her fans for their support. Dates included Manchester, Bristol and London where the mini-tour ended. Aquilina's song "Time to Say Goodbye" was featured in the season six advert for British drama "Downton Abbey". Aquilina released her debut album "Isn't It Strange?" under Island Records and Universal Music Group on 26 August 2016 (Enn Kosova-Maudling). On 10 October 2016 Aquilina announced on her Twitter and Facebook accounts that she was no longer going to be writing music or performing for herself and that "Isn't It Strange?" would be her last album. Aquilina returned to music in 2018 with "Psycho", from an EP due in 2019. In March 2019, she released a single ‘Tobacco in my Sheets’  Music reviewing website "Sound Of The Day" praised Aquilina's vocals in her cover of Lana Del Rey's "Born To Die": "[She] took this cover and exploded it, and took [Del Rey's] vocals to another level. She has convinced me that with her very touching and emotional feel to her voice, she can change the course of many up and coming musicians.