FXTAS may also result in changes in personality, due to alterations of the limbic area in the brain. This includes increased irritability, angry outbursts, and impulsive behaviour  FXTAS can be diagnosed using a combination of molecular, clinical, and radiological findings. In order for individuals to develop FXTAS, they must first be premutation carriers, having between 55-200 CGG trinucleotide repeat expansion of the FMR1 gene. A definite, probable, or possible diagnosis of FXTAS can be assigned based on combined clinical or radiological findings in conjunction with the molecular premutation. Clinical findings are divided into major and minor symptoms. Major symptoms include intention tremor and gait ataxia. Minor symptoms such as parkinsonism, short-term memory deficit, and executive function decline can further contribute to a diagnosis of FXTAS. Radiological findings are similarly divided into major and minor categories. As patients with FXTAS can have distinct brain scans from other movement disorders, a scan showing white matter lesions of the middle cerebellar peduncle is a major finding that can be attributed to FXTAS. Overall or generalized brain tissue atrophy and cerebral white matter lesions can also be minor indicators for a diagnosis. For a definite diagnosis to be made, a major radiological finding and one major clinical finding must be present. Probable diagnosis is based on the presence of either a major radiological finding and a minor clinical finding, or two major clinical findings alone. The possible category for diagnosis can be made with a minor radiological finding and a major clinical finding. The medical management of FXTAS aims to reduce the level of disability and minimize symptoms. Currently, there are many gaps in the research on the management of FXTAS. The disorder was first described in the literature in 2001. There is no treatment modality aimed at reversing the pathology of FXTAS. However, there are a variety of drug therapies that are being utilized in the management of FXTAS symptoms. There is a lack of randomized control trials assessing the efficacy these therapies, and support is limited to anecdotal evidence. Therefore, many of the treatments are based on what has been helpful in disorders with similar clinical presentations. There is no cure for FXTAS. Current treatment includes medications for alleviating symptoms of tremor, ataxia, mood changes, anxiety, cognitive decline, dementia, neuropathic pain, or fibromyalgia. Neurological rehabilitation has not been studied for patients with FXTAS but should also be considered as a possible form of therapy.