Mitotane was introduced in 1960 for the treatment of adrenocortical carcinoma. "Mitotane" is the generic name of the drug and its , , , and . Mitotane has been sold under the brand name Lysodren. Mitotane is also used to treat Cushing's disease (pituitary-dependent Cushing's syndrome) in dogs. The medication is used in the controlled destruction of adrenal tissue, leading to a decrease in cortisol production.