Dementieva's win over Ivanovic was her fourth in four career matches with her. Dementieva's next tournament was the İstanbul Cup, where Dementieva was the top seed and defending champion. She reached the final but was unsuccessful in her attempt to win a singles title at the same tournament in consecutive years, which would have been a career first. Agnieszka Radwańska of Poland defeated Dementieva in the final. At the French Open, Dementieva defeated eleventh-seeded Zvonareva in the fourth round, but lost her quarterfinal match against Safina in three sets after Dementieva had a match point while leading 5–2 in the second set. At the grass court Ordina Open in 's-Hertogenbosch, she was the top-seeded player but lost in the semifinals to Safina. Dementieva was seeded fifth at the Wimbledon. In the second round, she trailed Timea Bacsinszky 3–0 in the third set before winning the last six games of the match. In the fourth round, she defeated Shahar Pe'er to become the highest seeded woman left in the draw after the early round defeats of first seeded Ivanovic, second seeded Janković, third seeded Sharapova, and fourth seeded Kuznetsova. In the quarterfinals, Dementieva held on to defeat compatriot Nadia Petrova after Dementieva failed to hold serve while serving for the match in the second set at 5–1 and 5–3. In her first Wimbledon semifinal and her first Grand Slam semifinal since the 2005 US Open, Dementieva lost to eventual champion Venus Williams. Dementieva played three hard court tournaments during the summer and was seeded fifth at all three. She began her summer season by losing to Dominika Cibulková in the second round of the Tier I Rogers Cup in Montreal. At the Beijing Olympics, Dementieva was down a set and a break before defeating fourth-seeded Serena Williams in the quarterfinals. She then defeated compatriot Zvonareva in the semifinals and Safina in the three set final to win the gold medal. At the US Open, Dementieva was one of six players with the opportunity to be ranked world No. 1 upon completion of the tournament. Dementieva defeated Schnyder in the quarterfinals but lost to Janković in the semifinals.