The bigeyed sixgill, after an unknown gestation period, gives birth to litters of up to 13 pups. Because of the size of this shark, their main predators probably are larger sharks. Like many deepwater animals, the bigeyed sixgill is listed as DD (Data Deficient) by the IUCN Red List. Based on what little is known of the species, these sharks are not suffering major declines to their population, but pressure is growing from deepwater fisheries. According to the International Shark Attack File, the bigeyed sixgill is harmless, as its natural environment is far from people, and no attacks on humans by the species have been reported.