The Chelsea Handler Show  The Chelsea Handler Show is an American sketch comedy series that aired on the E! television network. The series starred Chelsea Handler and featured skits that mocked the entertainment industry, spoofed celebrities, television, the elderly, and herself. The show aired Friday nights at 10:30 EST. The mini-series was green lighted by E! in early 2006 and premiered on April 21, 2006. The cable channel ordered eight episodes of the half-hour project that features Handler, a "Tonight Show" correspondent and star of Oxygen's "Girls Behaving Badly", in taped spoofs, film shorts and field remote pieces, all framed by stand-up segments of her performing before a studio audience. The show originally ordered eight episodes which aired from April 21 to June 9 and was given an additional four episodes starting August 11 to create a 12-episode season. The show finished its run on September 8, 2006. Chelsea Handler began hosting the late-night comedy show, "Chelsea Lately" on July 16, 2007, also on E!.