Following its home finale against Indiana, Michigan traveled to Columbus, Ohio to face its arch-rival, the Ohio State Buckeyes, in the 115th playing of "The Game". Michigan was defeated by Ohio State 62–39. Ohio State opened the scoring in the first quarter via a 24-yard touchdown pass from Dwayne Haskins to Chris Olave. Michigan responded with a 39-yard field goal by Jake Moody. Michigan scored 16 points in the second quarter via a 31-yard field goal by Moody, a 23-yard touchdown pass from Shea Patterson to Nico Collins, and a nine-yard touchdown pass from Patterson to Chris Evans. Ohio State scored 17 points in the quarter via a 24-yard touchdown pass from Haskins to Olave, a 31-yard touchdown pass from Haskins to Johnnie Dixon and a 19-yard field goal by Blake Haubeil as time expired, which made the score 24–19 in favor of Ohio State at half-time. Ohio State added 17 points in the third quarter via a 19-yard field goal by Haubeil, a 33-yard punt return by Sevyn Banks and a two-yard touchdown run from Mike Weber. Michigan scored 20 points in the fourth quarter via a 12-yard touchdown pass from Patterson to Collins, a one-yard touchdown run from Ben Mason, and a four-yard touchdown run from Joe Milton. Ohio State added 21 points via a 78-yard touchdown run from Parris Campbell, a one-yard touchdown pass from Haskins to K. J. Hill, and a 16-yard touchdown pass from Haskins to Campbell. Michigan finished as co-champions of the Big Ten East Division with an 8–1 record in conference play, for their first division title since the conference introduced divisions in 2011. This was their best conference record since going 7–1 in 2004. On December 2, Michigan was selected to play in the Peach Bowl against the Florida Gators. Michigan won the previous meeting in the 2017 Advocare Classic, by a score of 33–17. This was Michigan's 47th bowl game appearance, and their first appearance in the Peach Bowl. Florida defeated Michigan 41–15. Florida opened the scoring in the first quarter via a 21-yard field goal by Evan McPherson. Michigan responded with a nine-yard touchdown pass from Shea Patterson to Donovan Peoples-Jones. Michigan extended their lead in the second quarter via a 48-yard field goal by Jake Moody. Florida added ten points in the quarter via a 26-yard field goal by McPherson and a 20-yard touchdown run from Feleipe Franks, which made the score 13–10 in favor of Florida at half-time.