TMEM128 has been found via yeast two-hybrid assays to interact with:   The biological function of TMEM128 is still poorly understood. As this is a transmembrane protein, common functions may include receptors, channels, or anchorage. Because TMEM128 has post-translational modification sites, alternative protein states may be present that permit TMEM128 to have different forms. For example, phosphorylation of TMEM128 may make it bind to different substrates through conformational change. TMEM128 also has a variety of interactions with other proteins as discussed above, suggesting it may have a broad range of action. TMEM128 has been found to show moderate to strong positivity in some patients with carcinoma, with other types of cancer such as melanoma, glioma, breast, ovarian, renal, and pancreatic showing weak to moderate positivity. TMEM128 also has been found to show low cancer specificity. "TMEM128" expression is experimentally associated with presence of the ROR alpha1 protein, as "TMEM128" was found in lower quantities when ROR alpha1 was deleted. "TMEM128" expression was lowered following a null mutation of TAp63 in skin cells. "TMEM128" expression was increased following a "Trypanosoma cruzi" infection. While it has been associated with several diseases such as Wolf-Hirschhorn Syndrome, no evidence exists for the exact cause of this syndrome and may only be correlation because of location on chromosome 4  Several SNPs have been found in association with TMEM128: