Wood was called up to replace injured Olly Stone in a 3-test tour of the West Indies. He did not play in the first 2 matches which England lost, but was drafted in to the team for the third test in St.Lucia. Wood bowled the fastest of any bowler in the match and in the Windies' first innings took 5 wickets for 41 runs off 8.2 overs - his first five-wicket Test haul helping England to a 142-run lead over West Indies on day two of the final test. In April 2019, he was named in England's squad for the 2019 Cricket World Cup. On 14 June 2019, in the match against the West Indies, Wood took his 50th wicket in ODIs. On 11 July 2019, in the semi-final against Australia, Wood played in his 50th ODI match for England. In the Cricket World Cup Final, Wood, batting at number 11, was run out off the last ball of the match which led to the game going to a Super Over. Wood also sustained a side injury during the game, which ruled him out of the first three Tests of the 2019 Ashes series. After missing the 2019 Ashes series and tour of New Zealand, Wood returned to Test cricket in the third test of the 2019-20 tour of South Africa following injuries to James Anderson and Jofra Archer. After scoring 42 runs from 23 balls in England’s first innings, he took 3/32 in South Africa's second innings as England won. In the fourth test, Wood took nine wickets, including 5/46 in South Africa's first innings, and scored 35 with the bat as England won again. On 29 May 2020, Wood was named in a 55-man group of players to begin training ahead of international fixtures starting in England following the COVID-19 pandemic. On 17 June 2020, Wood was included in England's 30-man squad to start training behind closed doors for the Test series against the West Indies.