Afterwards, Arizona answered with Warner completing a 62-yard TD pass to WR Larry Fitzgerald. However, in the fourth quarter, the Redskins pulled away with Campbell's 17-yard TD pass to WR Santana Moss. With the loss, the Cardinals fell to 2–1. Hoping to rebound from their road loss to the Redskins, the Cardinals flew to The Meadowlands for a Week 4 interconference duel with the New York Jets. After a scoreless first quarter, Arizona started to trail big in the second quarter. The Jets took flight with QB Brett Favre completing a 12-yard TD pass to WR Laveranues Coles, CB Darrelle Revis returning an interception 32 yards for a touchdown, Favre completing a 34-yard TD pass to Coles, kicker Jay Feely getting 20-yard field goal, Favre completing a two-yard TD pass to Coles, and Feely kicking a 30-yard field goal. In the third quarter, the Cardinals responded with RB Edgerrin James getting a four-yard and a two-yard TD run, along with rookie RB Tim Hightower getting a one-yard TD run. In the fourth quarter, New York answered with Favre's 17-yard TD pass to WR Jerricho Cotchery. The Cardinals would reply with QB Kurt Warner completing an eight-yard TD pass to WR Anquan Boldin, yet the Jets continued their victory march with Favre's 40-yard TD pass to Cotchery. Arizona tried to rally as Warner completed a 14-yard TD pass to WR Jerheme Urban, but New York sealed the win with Favre's 24-yard TD pass to TE Dustin Keller. With the loss, the Cardinals fell to 2–2. Hoping to rebound from their miserable road loss to the Jets, the Cardinals went home for a Week 5 interconference duel with the Buffalo Bills. In the first quarter, the Cardinals took flight as QB Kurt Warner completed a two-yard TD pass to WR Larry Fitzgerald. In the second quarter, Arizona increased its lead with rookie RB Tim Hightower getting a 17-yard TD run. The Bills responded with QB J. P. Losman completing an 87-yard TD pass to WR Lee Evans, yet the Cardinals answered right back with RB Edgerrin James getting a one-yard TD run. Buffalo would answer with Losman getting a two-yard TD run, yet the Cardinals continued its momentum with kicker Neil Rackers getting a 47-yard field goal. In the third quarter, the Bills tried to come back as kicker Rian Lindell got a 48-yard field goal, but Arizona kept its intensity up as Warner completed a two-yard TD pass to Fitzgerald.