US 11/PA 307 turns northeast onto city-maintained Jefferson Avenue, with one northbound lane and two southbound lanes. The road runs past downtown commercial development as it heads to the west of the University of Scranton campus. The two routes turn northwest onto state-maintained four-lane undivided Mulberry Street and runs past more businesses. Upon crossing Wyoming Avenue, the road becomes a divided highway and continues to an intersection with Mifflin Avenue. At this point, US 11/PA 307 becomes a four-lane freeway called the North Scranton Expressway and passes over a Delaware–Lackawanna Railroad line and the Lackawanna River. The highway comes to an interchange with Providence Road that provides a connection to 7th Avenue and access to Memorial Staduum. From here, the freeway heads north near residential and commercial development and runs parallel to Norfolk Southern's Sunbury Line to the west, coming to a diamond interchange with North Main Avenue. The highway continues north-northeast through more of the city alongside the railroad tracks, bending to the north-northwest. PA 307 splits from the US 11 freeway at a diamond interchange by heading west on four-lane undivided Keyser Avenue, passing under the Norfolk Southern tracks. The route turns north onto Morgan Highway, a three-lane road with two northbound lanes and one southbound lane and runs through wooded areas with some commercial development, curving to the northwest. PA 307 leaves Scranton for South Abington Township and traverses forested Bald Mountain, running a short distance to the northeast of the Pennsylvania Turnpike Northeast Extension (I-476). The road narrows to two lanes and continues through wooded areas with some homes, passing under I-476. The route continues through rural land and development and passes to the east of Summit Lake, bending to the north-northwest and heading into the borough of Clarks Summit. PA 307 curves west-southwest and reenters South Abington Township, running through a mix of fields and woods with some development. The road crosses into Newton Township and becomes Winola Road. The route passes to the north of Clarks Summit State Hospital and winds west through more rural land, passing to the north of the community of Schultzville. PA 307 enters Falls Township in Wyoming County and becomes Roosevelt Highway, continuing to wind west through forests with some farm fields and homes. The road curves to the north and passes through the community of Mill City, crossing into Overfield Township. The route heads north through forests to the community of Lake Winola, where it turns west and runs through wooded areas of homes to the south of Lake Winola.