Following the screening, a conversation was held featuring members of the cast and crew, including creator Shawn Simmons, actors Mark McKenna and Ciara Bravo, director Iain B. MacDonald, and writers and executive producers Greg Coolidge, Kirk Ward, Rhett Reese, and Paul Wernick. The series has been met with a positive response from critics since its premiere. On the review aggregation website Rotten Tomatoes, the series holds a 100% approval rating with an average rating of 8 out of 10 based on 10 reviews. In a positive review, "IndieWire"s Ben Travers awarded the series a grade of "A-" and praised it saying, ""Wayne" may feel familiar to other stories, "Bonnie and Clyde" included. But Simmons' thoughtful, engrossing, and altogether joyful new series carves its own path on the cold roads of America’s eastern seaboard." In another encouraging criticism, "Screen Rant"s Kevin Yeoman commended the series saying, "With its varying tones, stellar lead performances, and great supporting cast, "Wayne" is much more than the foul-mouthed action-comedy it makes itself out to be. The laughs may be pitch black at times, and the violence is occasionally shocking, but there’s a fascinating and entertaining sweetness woven into every scene that’ll hit you like a blast of rock salt to the heart." In an additional acclamatory critique, "Rolling Stone"s Alan Sepinwall gave the series a rating of 3½ out of 5 stars and was similarly approving saying, "Both the show and Wayne’s attempts to right the world’s wrongs don’t always work, but they mean well and are rarely dull." Within five days of the series premiere, the first episode had accumulated over 10 million views.