Second seeded Baylor needed overtime to prevail against fifteen seed UTSA. Head coach Kim Mulkey was not at the game, having been hospitalized earlier in the day due to a reaction to medication. Third seeded Louisville forced 27 turnovers in a win over Liberty. Fourth seeded Vanderbilt beat fifth seeded Kansas State behind a career-high 27 points by Jennifer Risper, and 24 points by Christina Wirth. Kansas State held a one-point lead at halftime, but Vanderbilt scored eleven consecutive points in a second half run to take a lead they would not relinquish. Second seeded Baylor beats South Dakota State on a last second shot. Kelli Griffin scored with 0.5 seconds remaining in the game to break a 58–58 tie, and move the Bears into the regional semi-final. Marissa Coleman has 18 points and 18 rebounds to lead top seeded Maryland over Utah on their home floor. Over ten thousand fans watched Maryland win its 35th consecutive game at home. Third seeded Louisville beat LSU on LSU's home floor. LSU had won twelve consecutive victories on their home floor. LSU's will not advance to the Final Four, ending an NCAA record-tying streak of five consecutive appearances. The win was the 31st of the year for Louisville, a school record. Three seed Louisville holds two seed Baylor to 39 points, in a surprisingly easy upset. Both Angel McCoughtry and Candyce Bingham had double-doubles to help lead the Cardinals to the first regional championship game in school history. Top seed Maryland survived a challenge from fourth seeded Vanderbilt. The Commodores started strong with an opening 12–2, which they extended to a 33–15 margin with six minutes left in the first half. Vanderbilt's Christina Wirth had a career-high 28 points, but it wasn't enough as Maryland's Marissa Coleman scored 42. Coleman scored the basket to give Maryland the lead with just under 30 seconds left in the game, and the clinching free throws. Third seeded Louisville knocks off top-seeded Maryland to head to their first ever Final Four. Angel McCoughtry had a double-double to lead the Cardinals to the win. Maryland hurt themselves with 21 turnovers. Louisville head coach Jeff Walz was a former assistant coach of Maryland. Fifth seed Virginia trailed at halftime, but came back to beat Marist. Sixth seeded Arizona State beat Georgia, despite playing without injured Dymond Simon. Third seeded Florida State had five players in double figure, helping win over North Carolina A&T.