Senyonjo was an inaugural contributor to "Bombastic Magazine", a publication concerning the Ugandan LGBTI community that was launched in December 2014. Senyonjo joined protesters for LGBTI rights, making a presentation in Jamaica at the 2016 Montego Bay Pride parade. On July 17, 2018, the University of Leeds awarded him the honorary degree of Doctor of Laws, for his outstanding work as clergyman and LGBT human rights defender in Uganda. In response to his ministry in Integrity Uganda, Senyonjo was told by Church of Uganda superiors to condemn the group and tell its members that they needed to convert to Christianity. Because of his disagreement with this position, and his refusal to condemn five young men he was counselling in 2001, his functions of vesting and laying on of hands were inhibited by the Archbishop of the Church of Uganda on behalf of the House of Bishops of Uganda in 2002, his pension for 24 years of service was stopped, and he stated that he began receiving death threats and harassment. In 2006 Archbishop Henry Luke Orombi speaking for the Church of Uganda denounced the Charismatic Church of Uganda as a "rebel denomination" and responded by completely dissociating itself from Senyonjo and stating that he was no longer a bishop and that they had "advised all civil authorities in Uganda that any licence held by Ssenyonjo for which his ordination in the Church of Uganda was an indispensable qualification shall now be null and void." Senyonjo responded, "I was consecrated in the Church of God. I belong to the Church in the royal priesthood of all believers." He said he was still a member of the Church of Uganda, and his only connection with the Charismatic Church of Uganda was to provide them with services when invited. California Senate Resolution 51, which called for greater scrutiny of the use of Section 501(c)(3) charitable status to lobby for discriminatory policies in other countries, noted Senyonjo "has been touring California, the United States, and Europe to educate and bring attention to the draconian impact of a recent wave of religious-based homophobia in Uganda", resolving in part that "the Senate commends the work and ministry of Right Reverend Christopher Senyonjo in his attempts to create an inclusive church and society in Uganda that is free from discrimination based on sexual orientation and gender identity." Senyonjo was included in "Huffington Post" list of the ten most influential people in religion in 2010. His entry noted, "The Bishop demonstrates what it means to have the courage of conviction, and faith enough to side with those whom Jesus called 'the least of these.'"