After graduating, he was recruited as Senior Economist from November 2008 to August 2010 with the African Development Bank (AfDB) Institutional Support program to the Ministry of Finance of Liberia. He was subsequently promoted as Principal Economist in August 2010 to January 2012. Sherif received professional training from a host of Universities including Duke University, USA; Harvard School of professional Education, USA; IMF Institute, USA; World Bank Institute in Washington DC, USA; He taught Business Statistics for four years and Public Finance for one year at the University of Liberia graduate program in Public Financial Management. Before ascending to his new position as General Manager of TRANSCO CLSG in September 2014, Mohammed Sherif worked as Chief Economist of Liberia at the Ministry of Finance from February 2012 – June 2014. In his professional career at the Ministry of Finance, Liberia, he played key role in the development of successful strategic programs in Liberia including the Poverty Reduction Strategy Paper (2008–2011), Agenda for Transformation (2012–2017), Liberia Public Finance Law of 2009 and took a technical lead role in the development of five Budget Framework Papers that underpinned Liberia's medium term budgets beginning fiscal year 2010/2011 up to 2014/15. Mohammed Sherif also worked on the Medium Term Debt Management Strategy of 2013, and Risks Analysis Strategy for budget execution of 2013/14. He served as the Energy sector focal person at the Ministry of Finance from 2008–2014. Mohammed Sherif also effectively coordinated the reporting requirements of the International Monetary Fund (IMF), Poverty Reduction and Growth Facility/Extended Credit Facility Program in Liberia from 2008 that led to Liberia achieving debt waiver under the Heavily Indebted Poor countries process in 2010. He also coordinated negotiations of a new IMF ECF program covering 2013–2015. He was involved in the preparation of various country Assistance strategies from 2009 to 2013, with multilateral institutions including the World Bank and the African Development Bank (AfDB). He directly participated in the negotiations of many credit agreements for Liberia including International Development Association (IDA) credits. As the General Manager of TRANSCO CLSG, Mohammed Sherif has earned himself a place among young African leaders who are making strives to transform their countries into fast growing economies. He remained a great asset to the government of Liberia until his ascendance to the top position at the TRANSCO CLSG (Côte d'Ivoire, Liberia, Sierra Leone and Guinea) which is interconnecting these countries to allow mutually beneficial power exchanges and a reliable electricity supply necessary for economic growth and consolidating the fragile peace that has been achieved so far in these countries.