She co-founded Cerebra, an early spin-off company to exploit Semantic Web technologies which has been sold. Goble was recipient of the first Jim Gray e-Science Award in December 2008. Tony Hey, corporate vice-president of Microsoft External Research who sponsored the award, said Goble was chosen for the award because of her work to help scientists do data-intensive science through the Taverna workbench. Her work has won best paper awards at the 3rd IEEE International Conference on e-Science and Grid Computing (2007) and the 11th ACM International Conference on Hypertext. In 2002 she was honoured by Sun Microsystems for her significant achievements in advancing Life Science Computing. She has given keynotes in many forums, including international conferences on: Digital curation, e-Social Science, Grid Computing, Intelligent Systems for Molecular Biology, Pacific Symposium on Biocomputing, Hypertext and Hypermedia, Bioinformatics Open Source Conference (BOSC), Artificial intelligence, Systems Biology, Discovery Science, the Semantic Web, International World Wide Web Conference and Medical Informatics. Goble was appointed Commander of the Order of the British Empire (CBE) in the 2014 New Year Honours for services to science. She was elected a Fellow of the Royal Academy of Engineering (FREng) in 2010. In January 2018 Goble was awarded the degree of Doctorem (Honoris Causa) by Maastricht University.