The interiors consist of a typical Victorian four square plan with a central stairway, connected to a two-storey staff wing. The main roof is titled in slate with terracotta ridging, while the staff wing roof is terra cotta tiled. The main house has a projecting bay at its east end and a projecting tower like room at its west end. The front northern elevation is covered with original timber and cast iron verandah, since enclosed and converted to bathrooms, kitchens, bedrooms etc. The garden features native trees, and is bordered by a cast iron gate and gate posts. A glass house, which was largely derelict for many years, was reconstructed in the 1990s, at which time the garden underwent sympathetic replanting. The combination of Wyoming's architectural qualities, its contextual impact, its degree of intactness and its historical associations make the villa a building of considerable cultural significance at the local, state and national level. This is one of the last waterfront Victorian villas remaining on the Balmain Peninsula. Architecturally, it is a fine example of the Italianate style, having been designed by the Mansfield Brothers, who were perhaps Sydney's pre-eminent mid Victorian architects. The villa has landmark qualities to Snails Bay and to Sydney Harbour. It has streetscape significance to Wharf Road and retains its original Victorian curtilage with a remnant garden. It has local significance for its association with Quarton Deloitte, known for his contribution to the local area and a pioneer in Australian rowing. It has state and international significance for its association with the eminent Russian scientist and humanitarian, Nicolai Miklouho-Maclay.