Ajayi played an active role in the Better Life for Rural Women project sponsored by the then First Lady of Nigeria, Maryam Babangida and was a delegate for the International Women's Conference held in Morocco and London. After horrific experience during the oppressive military regime in Nigeria, Chief Ajayi migrated to the United States of America in 1996 and, since then devoted her life to doing business that would serve her Nigerian community both in the US and Nigeria. After a brief self-imposed exile in the US, Chief Ajayi returned to Nigeria to revolutionize agriculture with the intention of helping in the eradication of poverty in the country. Chief Ajayi was the former National Coordinator of Goodluck Support Group (GSG) USA. She congratulated His Excellency, Muhammadu Buhari, GCFR, who is now the current President of the Federal Republic of Nigeria for his doggedness in winning the 2015 presidential election; and also praised the former president, Mr. Goodluck Jonathan for his extraordinary statesmanship, godliness and courage to become the first ever incumbent Head of State in Nigeria to lose an election and wholeheartedly accepted defeat peacefully to prevent post election violence and crisis in Nigeria  As a Community Activist, Chief Ajai has been lobbying the Nigerian federal government on behalf of all the Nigerians living in the diaspora in such areas as granting voting rights and approving housing scheme project for the diasporas. Her philanthropic goodwill gestures started when she established a Fashion/Technical school for underprivileged students in Ibadan, Nigeria in 1980–1985. Chief Ajayi later on championed and advocated for One Million Goodluck Housing Programme for the Diasporas in collaboration with the Federal Mortgage Bank of Nigeria under the DIASPORA HOUSING LOAN SCHEME. With the recent passing of the Bill establishing the Diaspora Commission, Chief Ajayi called on President Muhammadu Buhari to appoint credible individuals from the diaspora into the commission to ensure its success. In building cultural capacity and diversity, Temitope Ajayi held the First Nigerian Valentine Dinner Party. Which, in addition to breaking bread and fraternizing with fellow Nigerians, students ranging from 12 to 25 years old received educational achievement and community service awards from several government officials. The Congresswoman Barbara Lee, Mayor of Oakland Jerry Brown, State Senator Don Perata, San Francisco Mayor Gavin Newsom, and several others, made these awards available to all the recipients. When the First Lady of Nigeria died with 117 others in a plane crash in Nigeria in 2005, Temitope Ajayi held a memorial service in Oakland, California, which was attended by the Nigerian Consulate General of New York, Dr. F.R. Aderele.