An ensemble cast including Dulquer Salmaan, Nivin Pauly, Fahadh Faasil, Nazriya Nazim, Nithya Menen and Isha Talwar. Thiruvothu's performance as RJ Sarah was well appreciated & she went on to win several accolades, including the Filmfare Award for Best Supporting Actress - Malayalam. In 2015, she appeared in the romance film "Ennu Ninte Moideen" which narrated the tragic love tale of Kanchanamala and Moideen which happened in the 1960s in Mukkam, a riverside village in Kerala. The film opened to critical acclaim, with several critics regarding it as one of the greatest romance films made in Malayalam. Thiruvothu's performance was acclaimed critically & commercially. She went onto win many accolades most notably her first Filmfare Award for Best Actress - Malayalam  She is one of the founding members of Women in Cinema Collective, the organization for the welfare of women workers of Malayalam movie industry. Her final release of 2015 was Charlie alongside Dulquer Salmaan, Aparna Gopinath & Nedumudi Venu. The film went to win 8 Kerala State Film Awards, with Thiruvothu winning the Best Actress Award for both Charlie and Ennu Ninte Moideen. In 2016, Thiruvothu had one release, "Bangalore Naatkal", directed by Bommarillu Bhaskar, where she reprised her character RJ Sarah, from the Malayalam film "Bangalore Days". Thiruvothu had two releases in 2017. Her first release was Take Off, directed by Mahesh Narayan. The film also stars Kunchacko Boban and Fahadh Faasil. Celebrities praised the movie, including actor Kamal Haasan. The film was screened at international festivals, including International Film Festival of India and International Film Festival of Kerala. The film ran for over 125 days in theatres. Thiruvothu's performance was highly acclaimed. She went on to win  IFFI Best Actor Award (Female), becoming the first ever Indian film Actress to win the silver peacock award. She was also nominated for National Film Award for Best Actress, where she lost to Sridevi in the final round. But went on to win her first National Film Award – Special Mention a second Kerala State Film Award for Best Actress and her second Filmfare Award for Best Actress - Malayalam.