In Fossombrone, Felice helped noblemen and women in Rome, sending money and coordinating supplies. The Sack of Rome ended in 1528, but Felice did not immediately return to Rome because Napoleone had set up a force fighting against the Imperial attackers in Bracciano. Soon after, the Imperial forces dispelled Napoleone, and Felice felt safe returning. Once in Rome, Felice had the Orsini estate of Monte Giordano rebuilt for the sake of her sons and the family's reputation. Her property near Trinità dei Monti had also been ransacked and destroyed, so she had it rebuilt. The Sack of Rome had significantly changed Felice's life, and for the first time in her life she was poor. Though no official portraiture of Felice has been identified, Caroline Murphy has suggested two works might be depictions of Felice. These are Raphael's "The Mass at Bolsena" and Sebastiano del Piombo's portrait of an unknown woman. "The Mass at Bolsena" was commissioned by Julius II in 1512, and depicts the miracle of Bolsena. As Julius II was Raphael's patron, he would have influenced who exactly appeared in the painting. Both clergy and male members of the della Rovere family appear in the painting, as well as a few female figures. The figure Murphy identifies as Felice is dressed in black, kneeling, and gazing up at Julius II. She argues that this is possibly Felice because she is depicted differently from all the other female figures, who appear to be stylized. Sebastiano del Piombo was another painter who completed many works in this period, including portraiture. The fact that he was personally known to Felice, and the similarities in dress between this piece and "The Mass at Bolsena" led Murphy to suggest that Sebastiano del Piombo's portrait of an unknown woman is also a depiction of Felice. Felice's presence cannot be fully confirmed as she was never properly identified in these art pieces. However, as Julius II was a patron of the arts it is likely he included his daughter in some of the paintings he commissioned. Though Felice is less well-known than her female contemporaries such as Lucrezia Borgia and Isabella d'Este, she was a respected figure in her own time. She was acquainted with other 16th century figures such as Catherine de' Medici and Pope Leo X, and it is clear that despite the lack of documentation on her life, she was corresponding with various important people.