In December 2016, it was reported that Guilfoyle was being considered to serve as press secretary for President Donald Trump. Sean Spicer was ultimately selected. On the May 12, 2017, edition of "The Five", co-host Bob Beckel hinted that Guilfoyle turned the job down. However, in an interview with Bay Area News Group on May 15, 2017, Guilfoyle confirmed she was in contact with the White House about the position following Spicer's resignation. "I'm a patriot, and it would be an honor to serve the country", Guilfoyle said. "I think it'd be a fascinating job, it's a challenging job, and you need someone really determined and focused, a great communicator in there with deep knowledge to be able to handle that position." However, on May 19, Guilfoyle said she was under contract with Fox, indicating she turned down the White House. One month later she extended her contract with Fox. In 2018, "The Washington Post" described Guilfoyle as a "conservative cheerleader for President Trump." In 2020, Guilfoyle was reported to be a member of the finance committee of the Trump Victory Committee. The Trump campaign is paying Guilfoyle $180,000 a year through the campaign manager’s private company, Parscale Strategy. Guilfoyle has been a surrogate on the stump and taken on broad advisory roles. Guilfoyle left Fox News in July 2018, reportedly to work for a pro-Donald Trump Super PAC. A week after her announcement, though, the "Huffington Post" reported claims by an anonymous source who said that Guilfoyle did not leave the network voluntarily, but rather had been forced out due to allegations that she had engaged in sexual harassment." This was countered by other anonymous sources in "The Daily Beast", where it was reported that Guilfoyle's enemies within Fox had actively planted negative stories and started a whisper campaign against her, exaggerating her alleged misbehavior. In April 2020, Guilfoyle broadcast an interview with Larry Kudlow, director of the United States National Economic Council, on WABC (AM) discussing the massive unemployment report of the day, with the welcomed offset statement via tweet from President Trump on a possible Saudi-Russian oil-production cutback. Guilfoyle appeared in the 2004 film "" playing a public defender opposite Ed Asner and Shirley Temple's niece, Marina Black. The film was screened at the Tribeca Film Festival.