Radium-223 chloride, strontium-89 chloride and samarium-153 EDTMP are used to treat secondary cancer in the bones. Radium and strontium mimic calcium in the body. Samarium is bound to tetraphosphate EDTMP, phosphates are taken up by osteoblastic (bone forming) repairs that occur adjacent to some metastatic lesions. Beta emitting phosphorus-32 (32P), as sodium phosphate, is used to treat overactive bone marrow, in which it is otherwise naturally metabolised. An yttrium-90 (90Y) colloidal suspension is used for radiosynovectomy in the knee joint. 90Y in the form of a resin or glass spheres can be used to treat primary and metastic liver cancers. 131I-mIBG (metaiodobenzylguanidine) is used for the treatment of phaeochromocytoma and neuroblastoma. 177Lu is bound with a DOTA chelator to target neuroendocrine tumours. At the Institute for Transuranium Elements (ITU) work is being done on alpha-immunotherapy, this is an experimental method where antibodies bearing alpha isotopes are used. Bismuth-213 is one of the isotopes which has been used. This is made by the alpha decay of actinium-225. The generation of one short-lived isotope from longer lived isotope is a useful method of providing a portable supply of a short-lived isotope. This is similar to the generation of technetium-99m by a technetium generator. The actinium-225 is made by the irradiation of radium-226 with a cyclotron.