Delaware Route 52  Delaware Route 52 (DE 52) is a state highway in New Castle County, Delaware. The route runs from U.S. Route 13 Business (US 13 Bus.) in downtown Wilmington north to Pennsylvania Route 52 (PA 52) at the Pennsylvania border near Centerville. DE 52 runs through the city of Wilmington and passes through areas of the Brandywine Valley north of Wilmington. DE 52 intersects Interstate 95 (I-95)/US 202 and DE 2 in Wilmington and DE 100/DE 141 and DE 82 in Greenville. The entire route is designated as part of the Brandywine Valley National Scenic Byway, a National Scenic Byway and Delaware Byway while most of the route is also designated as part of the Harriet Tubman Underground Railroad Byway of the Delaware Byways system. The road was built as the Kennett Pike, a turnpike, between 1811 and 1813. The Kennett Pike was bought by Pierre S. du Pont in 1919 and was widened and paved before being sold to the State of Delaware for $1. The road received the DE 52 designation by 1936. DE 52 begins at US 13 Bus., which is routed on the one-way pair of North Walnut Street northbound and North King Street southbound, in the downtown area of the city of Wilmington. From here, DE 52 follows the one-way pair of East 11th Street southbound and East 12th Street northbound to the northwest, forming the northern boundary of Rodney Square along East 11th Street. The route becomes West 11th Street southbound and West 12th Street northbound at the North Market Street intersection. The one-way pair carries three lanes in each direction and heads northwest past downtown high-rise buildings, passing to the north of the DuPont Building along West 11th Street between North Market and North Orange streets and passing to the south of 1201 North Market Street along West 12th Street just west of North Market Street. The northbound direction passes south of Wilmington Hospital between North Washington and North Jefferson streets. Both directions of DE 52 merge onto Delaware Avenue, an eight-lane divided highway, and the route reaches an interchange with I-95/US 202. Past this interchange, the route narrows to six lanes and leaves downtown Wilmington. DE 52 splits from Delaware Avenue by continuing northwest on Pennsylvania Avenue, a four-lane undivided road that heads to the north of the Ursuline Academy and passes through urban areas of homes and businesses.