This intersection has park and ride lots on the northwest and northeast corners. Upon crossing MD 404, US 50 enters Talbot County and continues due south through open agricultural areas with a few homes. The road runs through a mix of farmland and woodland and reaches an intersection with the south end of the Wye Mills segment of MD 662. A short distance later, another section of MD 662 branches southeast from the route to head into Skipton. US 50 continues through farm fields and woods with some residential and commercial development, crossing MD 662. The road heads south through more rural land with occasional development to the east of Longwoods. Farther south, the route passes to the west of a golf course before it enters Easton. At this point, US 50 becomes closely parallel with MD 662 to the west and reaches an intersection with the southern terminus of MD 309. Past this intersection, the road heads between MD 662 and the Easton Airport to the west and commercial development to the east. MD 662 curves away to the west and the route runs between residences to the west and businesses to the east. The median of US 50 widens as it reaches an intersection with the northern terminus of MD 322, which serves as a western bypass of Easton and provides access from US 50 to the western Talbot County communities of Oxford, St. Michaels, and Tilghman Island. Following this intersection, the road crosses an abandoned railroad grade owned by the Maryland Department of Transportation before the median of the route narrows again and it passes through a mix of farm fields and commercial development. The road widens to six lanes and becomes lined with businesses as it heads through the eastern part of Easton, coming to an intersection with the western terminus of MD 328. Farther south, US 50 reaches a junction with the northern terminus of MD 331. Following this intersection, the roadway runs through residential and commercial areas, narrowing to four lanes. The route continues past more businesses, bending to the south-southwest, before it heads to the east of Easton High School. US 50 passes through a mix of fields and commercial areas before reaching a junction with the southern terminus of the MD 322 western bypass of Easton. At this point, the route leaves Easton and heads south through a mix of farmland and woodland with some businesses. US 50 has an intersection with the northern terminus of MD 565, which runs north-south to the west of US 50. The road continues south-southeast through a mix of agricultural areas and woods with some homes and businesses.