On November 19, 2007, Pierce was awarded an Honorary Doctor of Fine Arts Degree from Niagara University in Lewiston, New York. In 1999 he was awarded an Honorary Degree from Skidmore College, located in his native Saratoga Springs. In 2010, Pierce appeared in a revival of David Hirson's play "La Bête" directed by Matthew Warchus. The production debuted on London's West End before moving to New York. Also in 2010, Pierce had his first starring film role as Warwick Wilson in the dark comedy/psychological thriller "The Perfect Host". Pierce directed the Broadway production of the musical "It Shoulda Been You". In 2015 he directed the Manhattan Theater Club production of David Lindsay-Abaire's play "Ripcord" Off-Broadway at City Center. Pierce appeared in the Off-Broadway limited engagement of "A Life" by Adam Bock. The play premiered at the Peter Jay Sharp Theater on October 24, 2016, directed by Anne Kaufman, and closed on November 27. Pierce co-starred with Bette Midler in the Broadway revival of "Hello, Dolly!". The musical opened on April 20, 2017 at the Shubert Theatre. The show was a critical and box office hit. Pierce himself received a Tony Award nomination for Best Actor in a Musical for his performance. Pierce received a 2017 Drama League award nomination for "Hello, Dolly!" and "A Life". Pierce is known for his distinctive voice and, like his "Frasier" co-star, Kelsey Grammer, is often called upon to provide voice work. His notable roles include the narrator of the movie "The Mating Habits of the Earthbound Human" in 1999, the walking stick insect "Slim" in "A Bug's Life", Dr. Delbert Doppler in Disney's film "Treasure Planet", and amphibian Abe Sapien in "Hellboy". Pierce declined to be credited for his "Hellboy" role because he felt it was the performance of Doug Jones, and not his own voice, which ultimately brought the character of Abe Sapien to life. He was the voice for "Drix", a cold pill, in the animated comedy "Osmosis Jones". In a deliberate in-joke, he voiced Cecil, the brother of Kelsey Grammer-voiced Sideshow Bob, in "The Simpsons" episode "Brother from Another Series", in which the two characters parallel the Frasier-Niles relationship.