According to Eno, "This means the song has a funny balance, with two centers of gravity – their funk groove, and my dubby, reggae-ish understanding of it; a bit like the way Fela Kuti songs will have multiple rhythms going on at the same time, warping in and out of each other." According to bassist Tina Weymouth, her husband, drummer Chris Frantz, created the bassline by yelling during a jam, which she mimicked on bass guitar. She wanted to "leave lots of space for the cacophony that surrounded me. I felt like I was pounding away like a carpenter, just nailing away to get it in the groove." Eno wanted to remove the first note in the bassline, as he felt it was too "obvious", and rerecorded the part himself. When the band returned to New York and Eno had gone home, the engineer asked Weymouth to record the bassline again. She said: "It wasn't a big fight between me and Brian, as it has sometimes been portrayed, it was just a musical dispute." According to Frantz, Byrne "disappeared for two months" to write the lyrics. Byrne improvised lines as if he were giving a sermon, with a call-and-response chorus like a preacher and congregation. His vocals are "half-spoken, half-sung", with lyrics about living in a "beautiful house" with a "beautiful wife" and a "large automobile". "Guardian" writer Jack Malcolm suggested that the song can be read "as an art-pop rumination on the existential ticking time bomb of unchecked consumerism and advancing age". According to AllMusic critic Steve Huey, the lyrics address "the drudgery of living life according to social expectations, and pursuing commonly accepted trophies (a large automobile, beautiful house, beautiful wife)". Although the singer has these trophies, he questions whether they are real and how he acquired them, a kind of existential crisis. Byrne denied that the lyrics address yuppie greed and said the song was about the unconscious: "We operate half-awake or on autopilot and end up, whatever, with a house and family and job and everything else, and we haven't really stopped to ask ourselves, 'How did I get here?'" In the "Once in a Lifetime" music video, Byrne appears in a large, empty white room, dressed in a suit, bowtie and glasses. In the background, inserted via bluescreen, footage of religious rituals or multiple Byrnes appear.