In the year 10,001 B.C., a caveman runs away from a predator through a plain and immediately gets into a fight with Wolf (Ike Barinholtz). After defeating him, the caveman then encounters the predator, a saber-toothed, gasoline-drinking Amy Winehouse (Nicole Parker), who informs him that the world will end on August 29, 2008 and that their fate lies in a Crystal Skull. The sequence is then revealed to be a dream of everyman Will (Matt Lanter) in the present day. He then finds out that his girlfriend Amy (Vanessa Minnillo) is having an affair with Flavor Flav (Abe Spigner), and she breaks up with Will because he is not admitting his true feelings for her. Later that day, Will has a "Super Duper Sweet Sixteen" party at his house, despite being 25. The guests include Juney (Crista Flanagan), Dr. Phil (John Di Domenico), Will's best friend Calvin (Gary "G Thang" Johnson), and Anton Chigurh (Barinholtz), among others. During the party, Amy arrives with her new boyfriend, a Calvin Klein underwear model. The party then comes to a halt when the room shakes and the lights go out. A bulletin on the radio claims there is a meteor shower and it is the end of the world. Soon after, the city starts to freeze over, and Will, Juney, Calvin, and Calvin's girlfriend Lisa (Kim Kardashian) retreat to a garage for shelter. When Juney mentions that the calamities are caused by global warming, Will realizes his dream as a caveman could be related. Later, Will is chided by the others for not committing himself to his relationship with Amy. The gang leaves the garage and Will gets a call from Amy, where he admits his feelings for her before the call is dropped. He decides to go to rescue Amy. Lisa is later killed by a meteor. While the others comfort a distraught Calvin, Giselle (Parker), a prostitute, climbs out of a manhole and gets hit by a taxi. Calvin catches her, and they immediately fall in love with each other. Giselle's pimp, Prince Edwin (Tad Hilgenbrink), challenges Calvin to for her love, but a tornado appears and Prince Edwin flees. Iron Man (Gerrard Fachinni), Hellboy (Barinholtz), and the Hulk (Roland Kickinger) attempt to fight it, but all are defeated by cows thrown by the tornado.