Continuing from "Cable and X-Force" Cable puts together a new X-Force team with Psylocke, Dr. Nemesis, Fantomex, Marrow and new recruit MeMe in order to track down and deal with mutant threats using lethal force. The story is written by "" writer Simon Spurrier. Cable is infected with an extra-dimensional Super Soldier Serum that provides superpowers at the cost of killing them in around a year, however Cable is injected with an early version designed to kill him in a day. Cable's daughter Hope accidentally copies this virus, since it is based on super powers, and has to be placed into a coma in order to save her life. Cable cannot defeat the virus either, so he creates a new clone each day to replace himself but each clone still has only one day to live. Cable and X-Force eventually track down the man Volga who created the biotech virus and defeat him. However, Fantomex goes insane from needing to "be the best" and betrays the team using new god-like powers derived from a digitized form of the Volga Effect he had copied during a tryst with Meme. Nemesis and Forget-Me-Not unleashes hundreds of Cable clones to fight him, with Hope eventually stopping Fantomex and saving cable after the last clone is killed wherein her father stepped up to bat while about to catch fire from Volga's poison. Hope then takes over as leader of X-Force and "fires" Cable for his morally questionable methods. After travelling through time and fixing several mistakes that a future Deadpool caused, Cable and present-Deadpool eventually fix the timeline. The effects on the timeline causes Cable to revert to his original "status quo", with his robotic arm and his original telekinesis and telepathic power set. Cable is seen in the year 2087 dealing with some unidentified issue related to Stryfe, in the aftermath of an Inhuman attack that covers the city of Boston in sentient plant life led by the Shredded Man. He and his A.I. Belle eventually joins the rest of the Uncanny Avengers helping Synapse in the present and helps deal with the Inhuman causing the problems, before deciding to join the team when he learns the team's true mission is dealing with the Red Skull with Professor Xavier's brain and powers. After Captain America disbands the Uncanny Avengers in the aftermath of the "Civil War II" storyline and Cable and Rogue team up with villains Sebastian Shaw and Toad to find a cure for the Terrigen Mists, Rogue continues the team in their mission to stop the Red Skull.