On December 29, 1655, the Tyszowce Confederation was signed here, with the purpose of pushing Swedes out of Poland, and bringing back King Jan Kazimierz Waza. The document was signed by Hetmans Stanislaw Potocki and Stanislaw Lanckoronski, as well as several senators, military leaders and members of nobility. In 1767, Tyszowce became private property, and five years later, following the first partition of Poland, the town was annexed by the Habsburg Empire, as part of Austrian Galicia. Its population was divided between 200 Christian and 80 Jewish families. In 1803, Tyszowce burned in a great fire, and since 1815 until 1916, the town belonged to Russian-controlled Congress Poland. In 1847, its population reached almost 3,000, divided between Roman Catholics, Greek Catholics and Jews, and Tyszowce remained a private property of the Glogowski family. In 1869, Russian authorities stripped Tyszowce of its town charter, as a revenge for widespread support of the January Uprising (on May 18, 1863, the town was seized by rebel forces). In 1907 Tyszowce burned again, and in 1910, population of the village reached its maximum, at 7,620. Tyszowce suffered during World War I, it was destroyed, and by 1921, population was reduced to 4,420, including 1,592 Poles, 177 Ukrainians and 2,451 Jews. During World War II, 60% of Tyszowce was destroyed. The Jewish population numbered 2,454 Jews in 1921. In October, 1939 the village was occupied by the Nazis. About 1,000 Jews fled across the Bug River to the Soviet Union. In 1940, a forced labor camp was established in Tyszowce. During the night of April 16, 1942, the Nazis launched a massive execution of Jews in Tyszowce. Jews were brought to the square before the former public bath, where several hundred Jews were shot. The Nazis threw the corpses into a ditch. In 1942, about 2,000 Jews altogether, including some from Czechoslovakia, were deported to the Bełżec extermination camp. Another 150 Tyszowce Jews were deported to the Zamość labor camp. According to some sources, between June 1942 and the end of 1943, approximately 1,000 Jews from Tyszowce and surrounding towns were executed.