He led the Wolverines in tackles (106) for the third straight year, won the team's Frederick Matthei Award as player who displays leadership, drive and achievement on the athletic field and in the classroom, and was selected as a first-team All-Big Ten linebacker. As a senior, he was a team co-captain and started all 12 games at inside linebacker for the 1991 Michigan team that compiled a 10-2 record, outscored opponents 420-203, and was ranked #6 in the final AP Poll. In his final regular season game, Anderson had 17 tackles, including 16 solo tackles, one quarterback sack, and forced a fumble and recovered another, in a 31-3 victory over Ohio State, as the Wolverines limited the Buckeyes to 109 rushing yards. With a team-leading 102 tackles, Anderson became the only person in Michigan football history to lead the team in tackles for four consecutive years. At the end of the 1991 season, Cambpell was selected by the United Press International as a first-team All-American. He was also named the Co-Defensive Player of the Year in the Big Ten Conference, and he won both the Butkus Award and the Jack Lambert Trophy as the best collegiate linebacker in the country. He was named the 1991 winner of The Roger Zatkoff Award as the team's best linebacker. In January 1992, he participated in the 17th annual Japan Bowl. With eight minutes remaining in the game, he intercepted a Matt Rodgers pass that set up the game-winning touchdown in a 14-13 win for the East squad. After the game, East coach Johnny Majors called the interception "the work of an outstanding athlete" and called Anderson "an alert, smart player." In each of Anderson's four years at Michigan, the Wolverines defeated Ohio State, either won outright or tied for the Big Ten Conference championship and finished no lower than #7 in the final AP polls. During that time, Anderson compiled 390 tackles, including 286 solo tackles, a career tally that ranks third at Michigan behind Jarrett Irons (429) and Ron Simpkins (415). He also had 25 tackles for loss, seven quarterback sacks, six pass breakups, four fumble recoveries, and four interceptions. Anderson was selected by the Kansas City Chiefs in the seventh round (186th overall pick) of the 1992 NFL Draft. He appeared in eight games, one as a starter, for the Chiefs during the 1993 NFL season. He was waived by the Chiefs in late August 1994.