Past this interchange, PA 340 runs through less dense areas of residential and commercial development with some farm fields. At this point, the route enters the Pennsylvania Dutch Country of eastern Lancaster County, which is home to many Amish farms and businesses catering to tourists. The road enters the community of Smoketown and intersects the northern terminus of PA 896 to the south of Smoketown Airport. The route crosses Mill Creek and continues east to Bird-in-Hand, where it passes under Amtrak's Keystone Corridor. PA 340 enters Leacock Township and runs through open agricultural land with occasional residences. The road heads into Intercourse and passes homes and businesses. PA 340 intersects PA 772 and forms a concurrency with that route on Main Street, with the road gaining a center left-turn lane. PA 772 splits to the southeast and PA 340 passes more residential development on Old Philadelphia Pike. The road leaves Intercourse and loses the turn lane, continuing through more farmland. The route heads into Salisbury Township and runs through more rural areas, passing through the community of Spring Garden. PA 340 comes to an intersection with PA 897 and runs concurrent with that route before PA 897 turns south in the community of White Horse. Following this, the road runs east through more areas of farm fields, crossing Pequea Creek and passing through the community of Cains. PA 340 enters West Caln Township in Chester County and becomes West Kings Highway, passing southeast through woods and fields and reaching an intersection with PA 10 in Compass. At this point, PA 10 turns southeast for a brief concurrency with PA 340 before PA 340 splits to the east. The road runs through wooded areas with some homes and fields, passing through Wagontown. The route curves southeast before running east again and becoming the border between West Caln Township to the north and the city of Coatesville to the south. PA 340 crosses the West Branch Brandywine Creek and runs along the border between West Brandywine Township to the north and Coatesville to the south as it comes to the junction with PA 82 in the community of Siousca. Following this intersection, the road becomes East Kings Highway and runs along the border between West Brandywine Township to the north and Valley Township to the south as it runs through forested areas with some homes. The route enters Caln Township and heads southeast, passing over the US 30 freeway. PA 340 intersects Reeceville Road, which heads north to an interchange with US 30. The road curves northeast and comes to another bridge over US 30.