Calciumopathy  A calciumopathy is a disease caused by  disruption to the use of calcium within a cell. To a large extent, a calciumopathy is a type of channelopathy, or a  disease caused by disturbed function of ion channel subunits or the  proteins that regulate them; calciumopathies also include  dysfunctions of regulatory pathways and mitochondria. Many  calciumopathies are complex polygenic diseases; clues to their  understanding are coming from the rarer monogenic forms of common  symptoms such as seizures, ataxia, and  migraine.