Gayle leveraged the power of CARE's corporate and NGO partners to significantly expand CARE's reach across the globe. Under Gayle's leadership, CARE introduced three signature programs as part of its "Pathway to Empowerment." "Mothers Matter" focuses on child and maternal health, seeking to improve access to safe pregnancy and delivery services for 30 million women in Africa, Asia, and Latin America by 2015. "Power Within" focuses on girls' education, seeking to empower 10 million girls around the world to access quality primary education and gain leadership skills by 2015. And "Access Africa" focuses on microfinancing, seeking to ensure that 30 million people in 39 countries have access to a set of basic financial services by the next decade. In 2015, Gayle became inaugural CEO of McKinsey Social Initiative (now McKinsey.org), a nonprofit organization that implements programs that bring together varied stakeholders to address complex global and social challenges. As the inaugural CEO, Dr. Gayle set the direction for building the organization. McKinsey Social Initiative's first program, Generation, addresses the problem of youth unemployment, with programs in five countries—India, Kenya, Mexico, Spain, and the United States—and a goal of connecting one million young people with skills and jobs in five years. Gayle serves on several boards, including the Center for Strategic and International Studies, Colgate-Palmolive Company, the ONE Campaign, Coca-Cola, Brookings Institutions, New America, the Federal Reserve Bank of Chicago and the Economic Club of Chicago. She is a member of the Council on Foreign Relations, the American Public Health Association, the National Academy of Medicine, the National Medical Association and the American Academy of Pediatrics. Gayle also chaired the Obama Administration's Presidential Advisory Council on HIV/AIDS, and served on the President's Commission on White House Fellowships. Gayle has been named one of Foreign Policy magazine's "Top 100 Global Thinkers,", Newsweek's Top 10 "Women in Leadership," and "The Wall Street Journal"s "50 Women to Watch," as well as one of the "100 Most Influential Atlantans" and the "100 Most Influential Georgians." Additionally, she has been recognized as one of "Forbes"' "100 Most Powerful Women" and one of NonProfit Times' "Power and Influence Top 50". Gayle has published numerous scientific articles and been featured by media outlets like The New York Times, The Washington Post, ForbesWoman, Glamour, O magazine, National Public Radio, and CNN.