In 1845 he became headmaster of Farmer's College in College Hill, Ohio. He died in 1855 and was buried on the grounds of Farmer's College in a mound of earth which came to be known as the "Bishop Mound". More than 100 years later, Bishop's remains were re-interred at Miami University. Two of Bishop's most famous students were Jefferson Davis at Transylvania and Benjamin Harrison at Farmer's College. He recruited for the Miami faculty, William Holmes McGuffey and John Witherspoon Scott, father-in-law of Benjamin Harrison. Scott spoke at Bishop's funeral saying, in part, "during the changes and controversies originating in skeptical views among those controlling that (Miami) university, there was always one who nobly stood by the faithful Christian soldier, Dr. Bishop, and that was the national statesman, Henry Clay. He continued to implore the directors to retain Dr. Bishop,for, if they did not have one praying man in the university it surely would go down." Dr. Bishop was a prolific writer. His chief works were: