Lohr am Main is twinned with:  In 1956 the town undertook the sponsorship arrangement for Sudeten Germans driven out of their homeland in the town and district known in German as Preßnitz. The town itself no longer exists. In 1974, its former site became the bed of a new reservoir. The Main-Spessart Railway ("Main-Spessart-Bahn") from Würzburg and Gemünden leaves the Main valley on the way to Aschaffenburg–Frankfurt am Main and crosses through the Spessart. The from Lohr station through the town was a single-track, unelectrified, standard-gauge line to Wertheim. Passenger transport between Lohr-Town station and Wertheim was discontinued on 30 May 1976. Passenger service between Lohr-Bahnhof and Lohr-Town ended on 22 May 1977, although this part of the line is still in use for occasional goods transports. The former Lohr-Town station was converted to a pub. A direct early InterCity service to Munich was replaced with a Regionalbahn to Würzburg when the Nuremberg–Munich high-speed railway came into service in 2006. The nearest InterCityExpress stops are Aschaffenburg and Würzburg. On the eastern edge of town runs a short stretch of the "Mühlbergtunnel" on the Hanover-Würzburg high-speed rail line running north-south. Also within town limits runs a part of the Nantenbach Curve with the "Schönraintunnel". Lohr lies on "Bundesstraße 26", "", "Staatsstraße" (State Road) 2435 and "Staatsstraße" 2315. The nearest Autobahnen are the A 3 (Munich - Würzburg – Frankfurt) through the Weibersbrunn, Hösbach and Marktheidenfeld interchanges, and the A 7 (Würzburg - Kassel) through the Hammelburg interchange. The river Main is a "Federal Waterway" ("Bundeswasserstraße") of the first order, administered by the "". Lohr has at its disposal a "Kreiskrankenhaus" (District Hospital) with the disciplines of surgery, internal medicine, anaesthesiology, neurology, gynaecology, urology, ophthalmology and otolaryngology, and also the "Bezirkskrankenhaus" (Regional Hospital) for psychiatry, psychotherapy, psychosomatic medicine and forensic medicine for the "Regierungsbezirk" of Lower Franconia ("Unterfranken").