In 2009 1,700 people were treated for HIV/AIDS in the city of Brighton and Hove, and the Sussex Beacon forms an important part of the city's HIV/AIDS treatment and care strategy. The Sussex Beacon Half-Marathon, in which thousands of people participate annually, has been central to its fundraising efforts since it opened. Industrial development started in the early 20th century at the junction of Coombe Road and Lewes Road. Two large factories were built, both of which survive (but not in industrial use). On the north side of Coombe Road, Bernard Oppenheimer's diamond cutting company National Diamond Factories (Bernard Oppenheimer) Ltd built a large works in 1917. Employees included amputee former World War I soldiers. In 1927, it was subdivided into premises for Schweppes and the local electrical engineering company Allen West Ltd, whose works further up Lewes Road had been damaged by a lightning strike. C.V.A. Tools were the next occupants from 1945, but the factory closed in 1973 after a company takeover. In 2000 it was renovated and turned into flats with Art Deco touches. Immediately opposite, on the south side of Coombe Road, another diamond factory was built in 1918. Later, until it closed in 1991, it became the European base of Dentsply, a false teeth manufacturer. Since then it has been occupied by self storage space for the Big Yellow Group. Smaller factories further up Coombe Road belonged to producers of artificial limbs and asbestos, among other products. Allen West expanded further by building a large design and administration office in 1966 on land between Lewes Road and Dewe Road. Contraction in the electrical engineering industry rendered it redundant almost immediately, though: it closed in 1968 and was sold to a property developer in 1972. Five years later it was sold to Brighton Polytechnic (now the University of Brighton) and became Mithras House, one of the institution's main buildings. The nearest railway station is Moulsecoomb, which is about 10 minutes walk from many of the residential streets. The Compass Bus route 37B from Brighton railway station runs up Bear Road and Bevendean Road to terminate at Meadowview, while Brighton and Hove Buses route 38 starts from Meadowview and run via Coombe Road to Lewes Road, from where it continues in a loop around the New England Quarter to Brighton railway station. Bus journey times to the city centre are about 30 minutes. Heavy traffic along Lewes Road and Bear Road contrasts with the quieter environment of the terraced streets coming off them, but there is much on-street car parking as most houses lack their own off-street facilities.