WDFY3  WD repeat and FYVE domain-containing protein 3 is a protein that in humans is encoded by the "WDFY3" gene. This gene encodes a protein which contains WD repeats and an FYVE domain. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. This protein appears to act as a autophagy scaffolding protein. Mutations in this gene have been associated with neurodevelopmental delay, intellectual disability, macrocephaly and psychiatric disorders (autism spectrum disorders/attention deficit hyperactivity disorder).