Following this intersection, the route crosses over CSX's Philadelphia Subdivision railroad line on a bridge. The road narrows to two lanes and passes to the north of another cemetery. The route intersects DE 2, which follows the one-way pair of Lincoln Street northbound and Union Street southbound, in the Union Park Gardens neighborhood. At this point, DE 48 itself splits into a one-way pair that follows Lancaster Avenue eastbound and West Second Street westbound, with westbound DE 48 using westbound DE 2 (North Union Street) to get from West Second Street to Lancaster Avenue. The one-way pair carries two lanes in each direction. DE 48 continues into downtown Wilmington, where it crosses under a viaduct carrying I-95/US 202, with ramp connections to and from the southbound direction of I-95/US 202 via Jackson Street, which parallels I-95/US 202 to the west. Upon crossing under I-95/US 202, a westbound ramp to I-95/US 202 complements the eastbound direction of DE 48, with the road becoming Martin Luther King Jr. Boulevard, a six-lane divided highway. Westbound DE 48 remains along one-way West Second Street, which carries three lanes. DE 48 intersects the eastern terminus of DE 4, which provides access to DE 48 from the northbound direction of I-95/US 202. The one-way pair continues further into the downtown, passing to the south of the Orlando J. George, Jr. Campus of Delaware Technical Community College, and runs a short distance to the north of Amtrak's Northeast Corridor railroad line. The route intersects the southbound direction of US 13 Bus., which shifts west from North King Street to South Market Street where it intersects DE 48. At this point, the westbound direction of Martin Luther King Jr. Boulevard ends. Following the intersection with US 13 Bus. southbound, DE 48 follows the one-way pair of Front Street eastbound and East Second Street westbound. Along this stretch, the route passes to the north of Wilmington Station along the Northeast Corridor that serves Amtrak and SEPTA's Wilmington/Newark Line, with the train station's parking garage and the Wilmington Bus Station serving Greyhound Lines buses located between Front Street and East Second Street west of the French Street intersection. DE 48 reaches its eastern terminus at an intersection with the northbound direction of US 13 Bus., which follows Walnut Street, west of the Wilmington Transit Center serving DART First State buses.