Refer to table for details about the interacting proteins of C10orf71. Interacting proteins, their function if known, and any tissues they have been found or predicted to be expressed in and any diseases they have been associated with. There are currently no known paralogs to the C10orf71 gene. C10orf71 is known to have 68 orthologs in various species including primates (11 species), rodents (8 species), Laurasiatheria carnivores (14 species), Placental mammals (38 species), Sauropsida birds and reptiles (7 species), and fish (11 species). The highly conserved sequences are primarily from primates with the identity percentage of these species being >90%, whereas species such as reptiles, birds, and fish had an identity percentage ≤30%. Refer to table for additional information on dates of divergence, sequence length, and sequence identity and similarity for orthologs. C10orf71 is not present in prokaryotes, archaea, or fungi. Ortholog table in descending order to latest ortholog diverged. This table compares the orthologs analyzed, their species names, common names, dates of divergence from "Homo sapiens" ortholog (MYA), length (aa), and percentage of similarity and identity. A phylogenetic tree was constructed for the orthologs that were analyzed in comparison to "Homo sapiens." With the species of latest divergence being "Rhincodon types," or the whale shark. C10orf71's rate of divergence was faster than that of fibrinogen or Cytochrome C. There was a microarray experiment that also showed evidence that C10orf71's expression was lowered in skeletal muscle tissues that experienced sepsis. There was clinical significance found in the expression level of C10orf71 in an experiment looking at those with Myotonic dystrophy. One microarray analysis produced results that showed C10orf71's expression level decreased in those with prostate cancer as well.