The locality was hardly populated during 14th and 15th centuries and people used it as a merchandising trade place. Totana did not obtain the status of villa before the last years of the Reconquista. People started to exit the enclosed by a wall town of Aledo and move to plain lands, to the suburb of Totana from the year 1492. During the last decades of the Low Middle Ages and the first decades of the Modern period, the number of inhabitants was growing and Totana was expanding. With the purpose of ceasing people to move to Totana, the major of Aledo forbade house building in Totana except for the buildings for labourers. People did not take the notice of the order and even the major, councilors, wealthy people and the parish moved there during the following years. In the Early Modern Period there was a new urban structure that was created and two new neighbourhoods were settled: Sevilla and Triana. In Sevilla, there were quite religious buildings and the paths to Murcia, Cartagena, Lorca and Mazarrón. In Triana, there were the salaried workers dwellings. Throughout the 16th century, several plague epidemics took place in the Region of Murcia and it also had presence in Totana. The people of the town suffered famine and some unfortunate weather events. The 18th century was an apogee era for Totana, as well as for the Region of Murcia. Totana supported Philip II of Spain during the War of the Spanish Succession. As Philip II got the crown, the town was awarded with the 'Noble' status in 1709. Two new hydraulic structures were constructed. There were several aesthetic architectonical works such as the facade of the Parish Church of Santiago and a fountain named Fuente Monumental. In the census of 1755, 2303 people were listed and 201 members among those people lived in Aledo. In the year 1795 Totana and Aledo split and became two municipalities. The first years of the 19th century consisted of misfortune for the inhabitants of Lorca. In the year 1802, a reservoir in Lorca got broken, and that caused. Six years after, the Peninsular War broke. However, Totana was not invaded by the French and young male locals battled in the front against the invaders. In the year 1810 an epidemy of yellow fever spread and it caused to die half of the population of the town. During the mid-19th century, the crisis began to be overcome in Totana.