In the Michel Government formed in October 2014, she became Minister of Social Affairs and Health. When taking the oath, she described the portfolio as "her dream". Critics have said that she does not set the right example as Health Minister due to her obesity, and she has answered that "I know I'm not a model but you have to see what's inside, not the packaging". In the position, she was involved in coordinating the Belgian response to the Ebola virus epidemic in West Africa. In 2015, she became the most popular politician in Flanders, Wallonia and Brussels - making her the most popular politician in Belgium. In 2018, under her direction as health minister, the strategic reserve of FFP2 masks was destroyed because of being out of date and not replenished. DeBlock claimed she did not replenish them to save taxpayer money. This decision came under fire during the Coronavirus pandemic when the shortage of masks contributed to make Belgium one of the hardest-hit countries. In September 2018 she decided to introduce plain packaging for all tobacco products in Belgium. On 9 December 2018, it was announced that de Block would be responsible again for Asylum and Migration, replacing Theo Francken. She held the post in a previous government. Her official title since then is Minister of Social Affairs and Public Health, and Asylum Policy and Migration.