The Blue Devils scored sixteen consecutive points in one run spanning halftime which put the game out of reach. Duke won 74–47. South Carolina stayed close to Stanford for much of their game, but could not overcome the Cardinal. The Ogwumike sisters filled the stat sheet with Nneka scoring 39 points and pulling down ten rebounds, while sister Chiney lead the team in blocks and steals. Stanford pulled away late, then used a 9–0 run to put the game out of reaching, winning the game 76–60. Once again, the Ogwumike sisters contributed significantly to a Stanford victory. Nneka scored 29 points, while younger sister Chiney was the rebounding leader with 17. The Cardinal pulled out to a 15-point lead at halftime. Although the Duke Blue Devils were able to outscore Stanford in the second half, they only reduced the final margin to twelve, 81–69. Arkansas faced a double-digit deficit in the first half, but pulled even by halftime. In the second half, the defense of Arkansas prevailing, holding the Dayton flyers to zero field goals in the last twelve minutes of the game. The Razorbacks won, 72–55. The defending national champion Aggies held only a four-point lead at halftime over Albany, playing in its first ever NCAA Tournament appearance. The Great Danes were on a ten-game winning streak, but were unable to extend the run to eleven, as Texas A&M extended the lead in the second half, and won 69–47. After not sleeping well, Maryland's Alyssa Thomas struggled in the first half. She only had five points in the first half, while her team missed five of its first seven shots and fell behind early 8–4. The Terrapins moved out to a seven-point lead over Navy by the half, and after coach Brenda Frese urged Thomas to settle down, Thomas scored a dozen in the second half, and help lead the team to a 59–44 victory over the Midshipmen. The venue for Louisville's head coach Jeff Walz was familiar, as they were playing at Maryland, where he had served as an assistant coach for several years, including a national championship. The opponent were the Spartans, whose senior class had won at least one game in each of the prior three NCAA tournaments. The Cardinals would frustrate that streak, holding Michigan State to 55 points, and winning the game 67–55. There have been nine wins by thirteen seeds in history, and Marist now has three of them.