One of the more recent deaths by poisoning was that of Russian dissident Alexander Litvinenko in 2006 from lethal polonium-210 radiation poisoning. Today, poison is used for a wider variety of purposes than it used to be. For example, poison can be used to rid an unwanted infestation by pests or to kill weeds. Such chemicals, known as pesticides, have been known to be used in some form since about 2500 BC. However, the use of pesticides has increased staggeringly from 1950, and presently approximately 2.5 million tons of industrial pesticides are used each year. Other poisons can also be used to preserve foods and building material. Today, in many developing peoples of countries such as certain parts of Africa, South America and Asia, the use of poison as an actual weapon of hunting and attack still endures. In Africa, certain arrow poisons are made using floral ingredients, such as of that taken from the plant "Acokanthera". This plant contains ouabain, which is a cardiac glycoside, oleander, and milkweeds. Poisoned arrows are also still used in the jungle areas of Assam, Burma and Malaysia. The ingredients for the creation of these poisons are mainly extracted from plants of the "Antiaris", "Strychnos" and "Strophanthus" genera, and "Antiaris toxicaria" (a tree of the mulberry and breadfruit family), for example, is used in the Java island of Indonesia, as well as several of its surrounding islands. The juice or liquid extracts are smeared on the head of the arrow, and inflicts the target paralysis, convulsions and/or cardiac arrest, virtually on strike due to the speed in which the extracts can affect a victim. As well as plant based poisons, there are others that are made that are based on animals. For example, the larva or pupae of a beetle genus of the Northern Kalahari Desert is used to create a slow-acting poison that can be quite useful when hunting. The beetle itself is applied to the arrow head, by squeezing the contents of the beetle right onto the head. Plant sap is then mixed and serves as an adhesive. However, instead of the plant sap, a powder made from the dead, eviscerated larva can be used.