The experiment on Psylocke served as a test run for Pryor. The Sisterhood commences a surprise raid on the X-Men's base, quickly neutralizing several of the main X-members. Recovering from the initial attacks, the X-Men force the Sisterhood (now including a brainwashed Psylocke) to retreat. But the battle was only a distraction, as the real purpose was for Madelyne to locate Jean Grey's gravesite. Madelyne's own body had been cremated after her suicide, so Grey's seemed the only option available to her. At Jean's grave, Madelyne attempts to repeat the ritual with her corpse. However, Cyclops had correctly guessed Madelyne's goal and had arranged for Grey's body to be replaced with another, which Madelyne only learned after it was too late. The second she bound herself to the corpse, she discorporated as the decayed body could not contain her vast psionic energies. During the 2012 "Avengers vs. X-Men" storyline, Mister Sinister had created a group of six Madelyne Pryor clones in order to take the Phoenix Force energies from the Phoenix Five (consisting of the Phoenix Force-empowered Cyclops, Colossus, Emma Frost, Magik, and Namor). Unlike the original Madelyne, none of the six clones showed indications of having individual personalities or free will, but instead appeared to follow Sinister completely. The Madelyne Pryor clones joined Sinister's other clone creations in fighting the Phoenix Five and managed to defeat each one. They also were able to siphon some of the energy from the Phoenix Force, but they all were immediately killed by the entity itself. Lady Deathstrike, whose consciousness had taken possession of a Colombian girl named Ana Cortes, formed an all new Sisterhood initially composed of her, the mutant Typhoid Mary, and the exiled Asgardian Amora (the Enchantress). The sentient bacteria Arkea possessed Lady Deathstrike's assistant Reiko and joined. As Arkea feared being opposed by the X-Men, she wanted powerhouses with the Sisterhood, so she had Enchantress use her magicks to restore Selene and also planned to resurrect Madelyne Pryor. Ana Cortes managed to turn against Deathstrike, contact the X-Men and alert them of the Sisterhood's location, and then committed suicide in an attempt to prevent Arkea's plans. Arkea was able to place Deathstrike's consciousness into Reiko also, and seeing an opportunity, spliced Jean Grey's DNA to Ana's body, making it a fully compatible host for Madelyne Pryor.