Muscatine is located along two designated routes of Iowa's "Commercial-Industrial Network", U.S. Highway 61 and Iowa Highway 92. Highway 61 serves as a major agricultural-industry route to the south from Burlington to Muscatine, where it becomes a heavy-industrial and major commuter route to the northeast between Muscatine and Davenport. In conjunction with Iowa 92, which provides access to the Avenue of the Saints (U.S. 218/IA 27) to the west and the lightly populated western Illinois via the Norbert Beckey Bridge to the east, Highway 61 serves as a shortcut for traffic from northeastern Missouri and southeastern Iowa en route to the Quad Cities, Chicago, and points beyond. Several regional highway improvement projects are in the works to further establish and capitalize on this trade-route. Additionally, Muscatine is connected to Interstate 80 to the north by fifteen miles () of Iowa Highway 38. Iowa Highway 22 also connects with U.S. 218/IA 27 to the west, and Davenport to the east.