As with the entire region, Mount Macedon is susceptible to severe frost, generally between the months of May and September, with light frosts throughout the rest of the year and minimal frost between January and March. Extreme minimums have been recorded near . A feature of the region in winter is the occasional appearance of black ice. On 8 November 1948, Douglas DC-3 VH-UZK operated by Australian National Airways crashed on Mount Macedon a few minutes after leaving Essendon Airport. The pilot and first officer died; the cabin crew and all 19 passengers survived, with relatively minor injuries. The event is commemorated on a plaque in Cross Reserve.