The Agreement also incorporates many of the provisions of the proposed European Patent Litigation Agreement. The unitary patent provisions will only apply once the Agreement on a Unified Patent Court enters into force. The Court of First Instance would have a central division with its seat in Paris, and thematic sections in London, focusing on chemistry cases, including pharmaceuticals, (in International Patent Classification (IPC) classification C), and human necessities (in IPC classification A) and Munich (mechanical engineering cases in IPC classification F) are each expected to take about 30% of the caseload. Furthermore, participating countries may set up a single or, if conditions regarding minimum case load are met, multiple local divisions of the court. Countries may also set up a "regional division", serving as the local division of the group. The agreement does not define which countries would set up local or regional divisions. The court of Appeal would be located in Luxembourg and would also serve as the registry. Training of judges would take place in Budapest, and Lisbon and Ljubljana would host Patent Arbitration and Mediation Centres. The training centre for judges and candidate judges was officially opened on 13 March 2014 in Budapest. While the locations of the Central Court have been fixed in the Annex to the Agreement on a Unified Patent Court, contracting states are free to set up local or regional divisions up to a maximum number. Not all locations of regional and local divisions have been announced. The characteristics of the known divisions and their territorial jurisdiction is shown below:  The system would include both legally qualified and technically qualified judges, who would sit in a composition of three (Court of First Instance) or five (Court of Appeal) judges. Local divisions may request (on their own or on the request of one of the parties) to have an extra technically-qualified judge added. An overview of the composition of the judges is shown below:  A Of different nationalities B Upon request of one of the parties (or the panel)  Appeals may be brought before the Court of Appeal on both points of law and on the facts of the case. In the case of questions regarding the interpretation of EU law, questions can be submitted to the European Court of Justice. Proceedings would take in principle place in the local language of the division and in the language in which the patent was granted (English, German or French) in the central division. The Court of Appeal would proceed in the language used at the Court of First Instance. Three committees are to be constituted "to ensure effective operation and implementation" of the Agreement: A preparatory committee was established enabling entry into force when the required number of ratifications is reached.