The roads curve to the south as they enter Gainesville, where US 441 goes south onto 13th st while SR 20 heads southeast on 6th street to then go south to parallel US 441. SR 20 then goes east on 8th Avenue and then south onto Main Street before turning east again on SR 24/26. Finally, SR 20/24/26 goes east, then SR 20 goes southeast on Hawthorne Road to Hawthorne, where it intersects US 301, to enter Putnam County. As SR 20 goes slightly northeast, it intersects SR 21. Going east, the route goes to Interlachen where it intersects CR 315, where the road increases to four lanes to Palatka. The road is kept four lanes through Palatka, where it is known as Crill Avenue, and intersecting SR 19, then heads east to Palm Avenue where it is reduced to two lanes. SR 20 continues to head east along Crill Avenue, then turns north on 9th avenue to US 17, where they cross the St Johns River on the Palatka Memorial Bridge and curve south in East Palatka toward San Mateo, where SR 20 leaves the concurrency with SR 100 from US 17 to head southeast out of Putnam County. SR 20/100 continue their southeasterly direction for a bit to head straight east to intersect CR 305 and CR 205, then they go east to go into Bunnell, where SR 20 ends at US 1 just after going over an overpass. SR 100, however, goes concurrent with US 1 to Bunnell and continues to SR A1A. The portion of SR 20 running through all of Calhoun County was designated as "Fuller Warren Parkway" by the Florida State Legislature in 1999. The portion of SR 20 that runs in a hidden concurrency with US 27 in Leon County was designated as "Apalachee Parkway" by the Florida State Legislature in 1961. The portion of SR 20 that runs in a hidden concurrency with US 27 in Leon, Jefferson, Madison, and Taylor counties was designated as "Blue Star Memorial Highway" by the Florida State Legislature in 1957. The same portion of SR 20 in Taylor, Jefferson, and Leon counties was also designated as "Paradise Drive" by the Florida State Legislature in 1951. The portion of hidden SR 20 from Perry to High Springs in Columbia County, as well as all of SR 20 that runs as a hidden concurrency with US 27 in Lafayette and Suwannee counties, was designated as "Fred P Parker Memorial Highway" by the Florida State Legislature in 1941.