The first legs were played on 5–7 February, and the second legs were played on 12–14 February 2019. "Atlético Mineiro won 5–4 on aggregate and advanced to the third stage (Match G1)." "Melgar won 1–0 on aggregate and advanced to the third stage (Match G2)." "Libertad won 6–2 on aggregate and advanced to the third stage (Match G3)." "Tied 2–2 on aggregate, Palestino won on penalties and advanced to the third stage (Match G4)." "Talleres won 2–0 on aggregate and advanced to the third stage (Match G4)." "Atlético Nacional won 1–0 on aggregate and advanced to the third stage (Match G3)." "Tied 1–1 on aggregate, Caracas won on away goals and advanced to the third stage (Match G2)." "Defensor Sporting won 3–1 on aggregate and advanced to the third stage (Match G1)." The first legs were played on 19–21 February, and the second legs were played on 26–28 February 2019. "Atlético Mineiro won 2–0 on aggregate and advanced to the group stage (Group E)." "Melgar won 3–2 on aggregate and advanced to the group stage (Group F)." "Tied 1–1 on aggregate, Libertad won on penalties and advanced to the group stage (Group H)." "Palestino won 4–3 on aggregate and advanced to the group stage (Group A)." The two best teams eliminated in the third stage enter the Copa Sudamericana second stage. Only matches in the third stage are considered for the ranking of teams.