After his term as lieutenant governor he retired from his business and political interests. On November 25, 1908, he married Louise Maxwell, who was born to American parents in Cawnpore, India, where her father was serving as a missionary. Together, Louise and Edwin were the parents of:   He died on a hospital operating table in Bar Harbor, Maine during a second leg amputation, which was necessary because of gangrene derived from diabetes. He was buried at the Albany Rural Cemetery in Menands, New York.