Laetus continued to teach at the University of Rome until his death in 1498. Pope Sixtus IV permitted the resumption of the Academy meetings, which continued to be held until the sack of Rome in 1527. Laetus's importance in cultural history lies mostly in his role as a teacher. On his death he was buried in the church of San Salvatore in Lauro in Rome. Laetus, who has been called the first head of a philological school, was extraordinarily successful as a teacher; he said that he expected, like Socrates and Christ, to live on through his pupils, some of whom were many of the most famous scholars of the period. Among those put under his charge to be educated were Alexander Farnese, later pope Paul III. His works, written in sophisticated classicizing Latin, were published in a collected form ("Opera Pomponii Laeti varia", 1521). They contain treatises on the Roman magistrates, priests and lawyers, and a compendium of Roman history from the death of the younger Gordian to the time of Justin III. Laetus also wrote commentaries on classical authors, and promoted the publication of the "editio princeps" of Virgil at Rome in 1469.