"Indefatigable" was then paid off later that year. "Indefatigable" was laid up in ordinary at Plymouth in March to April 1802, as a result of the peace of October 1801. Following the resumption of hostilities, the "Indefatigable" was fitted out for sea between July and September 1803. She was recommissioned under Captain Graham Moore, younger brother of Sir John Moore of Rifle Brigade and Corunna fame. "Indefatigable", with Moore as Commodore, and frigates "Medusa", "Lively", and "Amphion" intercepted four Spanish frigates off Cadiz under the command of Rear-Admiral Don Joseph Bustamente, Knight of the Order of St. James, on 5 October 1804. They were carrying bullion from Montevideo, South America to Spain. Spain was a neutral country at the time, but was showing strong signs of declaring war in alliance with Napoleonic France. Acting on Admiralty orders, Moore required the Spaniards to change their course and sail for England. Admiral Bustamente refused and a short engagement ensued. First "Mercedes" blew up. Then "Indefatigable" captured "Medée", and "Lively" captured "Clara". After a further chase, "Lively" and "Medusa" captured "Fama". "Indefatigable" had no casualties. "Amphion" had five men wounded, one badly. "Lively" had two killed and four wounded. "Indefatigable" and "Amphion" escorted "Medée" and "Fama" to Plymouth. "Medusa" and "Lively" brought in "Clara". The Royal Navy took "Medea" into service as and "Clara" as . The value of the treasure was very large and, if it had been treated as Prize of War, then Moore and his brother captains would have become extremely wealthy. As it was, the money and ships were declared to be "Droits of Admiralty" on the grounds that war had not been declared, and the captains and crew shared a relatively small "ex gratia" payment of £160,000 for the bullion, plus the proceeds of the sale of the hull and cargo. On 4 November 1804 recaptured the ship "William Heathcote" from the French. "Indefatigable" shared by agreement. In October 1805 "Indefatigable", now under Captain John Tremayne Rodd (−1809), was part of the blockade of Brest.