In 1936, Jeater, Rodd and Hay, honorary architects for Newcastle Hospital, were instructed to prepare plans for converting the Home into a clinic for Sister Elizabeth Kenny. While this firm prepared the necessary plans for the work, at the last minute the job was transferred to the New South Wales Government Architect. In 1938 it became the Sister Kenny Poliomyelitis Clinic. Elizabeth Kenny was an Australian bush nurse who discovered a revolutionary treatment for infantile paralysis and devoted her life to the dissemination of this treatment throughout Australia and abroad. She went against traditional treatments for polio and urged that the stricken limbs be exercised. Between 1935 and 1940 she traveled extensively throughout Australia helping to set up clinics. In 1940 the Government of New South Wales sent Kenny to America to present her clinical method for treating polio victims to American doctors. Several clinics were also established across the US. Sister Kenny's clinic was shortlived, being transferred from the Home in 1941 when the Infectious Diseases Hospital, Western Suburbs was opened. Between 1938 and 1941 Dr Ethel Burn had a chest clinic in the building. Following the transfer of the poliomyelitis clinic, it was decided that the Home should be re-modelled as a maternity hospital. When the alterations were almost complete, however, the Chief Gynaecologist at the Hospital declared the building unfit for that purpose because of all the dirt and dust from the railway station and the Zaara Street Power Station, so that project was abandoned. For the next ten years the building was left almost entirely vacant. However, during the latter part of World War 2 it became a store for air raid precautions gear. Soon after the War the Chief Radiographer at the Hospital occupied part of the ground floor, whilst the Hospital Social Club held their meetings in another part of the building. In 1949 sketch plans were drawn up by the Hospital's architects, for the site's conversion to a Nurses' Home, but plans for this fell through. According to the terms of the re-dedication in 1935, the land was given as a "deed of gift" to the Hospital until the Hospital no longer wanted it. In 1952 the Hospital returned the land to the State Government. The Government then used it to house its various offices, including the Departments of Education, Health, Mines, Weights and Measures and Labour and Industry. During the alterations required to convert the building to the headquarters of NSW State Government Departments in Newcastle, the Superintendent's verandah was demolished. The columns from this verandah were used to form the supports for a new verandah along the eastern side of the west wing.