Tiznow has established himself as an important sire, particularly of classic distance types like 2008 Belmont Stakes winner Da'Tara, Well Armed, the winner of the 2009 Dubai World Cup, Colonel John, winner of the 2008 Travers Stakes and Gemologist, winner of the 2012 Wood Memorial Stakes. Tiznow is also a developing sire of sires, having at least 13 sons at stud in the U.S.  Notable offspring of Tiznow include: Tiznow is also an emerging broodmare sire, known for transmitting stamina. Notable descendants as a broodmare sire include Tiz the Law (2017), whose most notable achievments are winning the Florida Derby and Belmont Stakes. Tiznow's sire Cee's Tizzy, who was raced by Cecilia Straub-Rubens, was one of California's most successful sires. At the time of his death in October 2015, he had sired 39 stakes winners and numerous California champions. His progeny earnings were more than $37 million. Tiznow's dam, Cee's Song, was also raced by Straub-Rubens. Cee’s Song produced nine foals by Cee's Tizzy, including Tiznow and stakes winners Budroyale, Tizbud, and Tizdubai, plus two Grade-I-stakes producing daughters: Tizso (dam of Paynter) and Tizamazing (dam of Oxbow). After Straub-Rubens death, Cee’s Song was purchased carrying Tizamazing for $2.6 million at the 2001 Keeneland November breeding stock sale. Relocated to Kentucky, Cee’s Song produced four more offspring including stakes-placed C’Mon Tiger, by Storm Cat, and his winning full sister You’re Beautiful. Cee's Song died in 2011 from the infirmities of old age. Tiznow is inbred 4 × 4 to Northern Dancer.