Guthrie resides in the town of Washington, Massachusetts, where he and Jackie Hyde, his wife of 43 years, were long time residents. Jackie died on October 14, 2012, shortly after being diagnosed with liver cancer. He also has a home in Sebastian, Florida. Guthrie's son Abe Guthrie and his daughters Annie, Sarah Lee Guthrie, and Cathy Guthrie are also musicians. Abe Guthrie was formerly in the folk-rock band Xavier and has toured with his father. Annie Guthrie writes songs, performs, and takes care of family touring details. Sarah Lee performs and records with her husband Johnny Irion. Cathy plays ukulele in Folk Uke, a group she formed with Amy Nelson, a daughter of Willie Nelson.