This marriage produced four children before her death while taking the smallpox inoculation during the Revolutionary War in 1777, including:   His fifth and final marriage was in 1778 to Susannah Perrin (1753–1783). Together, Susannah and Samuel were the parents of:   Washington, who suffered from tuberculosis, as did many of his wives and sons, died at age 46 on September 26, 1781, in Berkeley County, Virginia, three weeks before the decisive Franco-American victory of Yorktown. His probable cause of death was from tuberculosis, or a similarly contagious and recurring respiratory disease. Through his son George, he was the grandfather of Samuel Walter Washington (1799–1831), who married Louisa Clemson, sister of Ambassador Thomas Green Clemson, who served as the United States Superintendent of Agriculture and founded Clemson University in South Carolina.