Dies's "Biographische Nachrichten" is the work of a sentimental artist who fancied himself a "universal man" but whose approach to the problem of biography was that of his time and place. In 1787, he accidentally swallowed of lead acetate. He never recovered from the ensuing lead poisoning, which caused the loss of one of his hands, and eventually died in Vienna on 28 December 1822. Dies is perhaps better known today from his acquaintanceship (e.g. Goethe, Haydn) than from his own merits as an artist or writer. The "Encyclopædia Britannica" Eleventh Edition gives harsh opinions of Dies's work as an artist:   Gotwals writes, "Friedrich Noack in his article in the Thieme and Becker "Allgemeines Lexicon der bildenden Künstler" ["General lexicon of graphic artists"], describes Dies's work as clumsy, mediocre, and prosaic. Gotwals adds, concerning Dies's writing, that "his literary style is hardly better." Tyramine  Tyramine ( ) (also spelled tyramin), also known under several other names, is a naturally occurring trace amine derived from the amino acid tyrosine. Tyramine acts as a catecholamine releasing agent. Notably, it is unable to cross the blood-brain barrier, resulting in only non-psychoactive peripheral sympathomimetic effects following ingestion. A hypertensive crisis can result, however, from ingestion of tyramine-rich foods in conjunction with the use of monoamine oxidase inhibitors (MAOIs). Tyramine occurs widely in plants and animals, and is metabolized by various enzymes, including monoamine oxidases. In foods, it often is produced by the decarboxylation of tyrosine during fermentation or decay. Foods containing considerable amounts of tyramine include:  Evidence for the presence of tyramine in the human brain has been confirmed by postmortem analysis. Additionally, the possibility that tyramine acts directly as a neuromodulator was revealed by the discovery of a G protein-coupled receptor with high affinity for tyramine, called TAAR1. The TAAR1 receptor is found in the brain, as well as peripheral tissues, including the kidneys. Tyramine binds to both TAAR1 and TAAR2 as an agonist in humans. Tyramine is physiologically metabolized by monoamine oxidases (primarily MAO-A), FMO3, PNMT, DBH, and CYP2D6.