These products of ozone chemistry include formaldehyde, higher molecular weight aldehydes, acidic aerosols, and fine and ultrafine particles, among others. The higher the outdoor ventilation rate, the higher the indoor ozone concentration and the more likely the reactions will occur, but even at low levels, the reactions will take place. This suggests that ozone should be removed from ventilation air, especially in areas where outdoor ozone levels are frequently high. Recent research has shown that mortality and morbidity increase in the general population during periods of higher outdoor ozone and that the threshold for this effect is around 20 parts per billion (ppb). It is common to assume that buildings are simply inanimate physical entities, relatively stable over time. This implies that there is little interaction between the triad of the building, what is in it (occupants and contents), and what is around it (the larger environment). We commonly see the overwhelming majority of the mass of material in a building as relatively unchanged physical material over time. In fact, the true nature of buildings can be viewed as the result of a complex set of dynamic interactions among their physical, chemical, and biological dimensions. Buildings can be described and understood as complex systems. Research applying the approaches ecologists use to the understanding of ecosystems can help increase our understanding. “Building ecology “ is proposed here as the application of those approaches to the built environment considering the dynamic system of buildings, their occupants, and the larger environment. Buildings constantly evolve as a result of the changes in the environment around them as well as the occupants, materials, and activities within them. The various surfaces and the air inside a building are constantly interacting, and this interaction results in changes in each. For example, we may see a window as changing slightly over time as it becomes dirty, then is cleaned, accumulates dirt again, is cleaned again, and so on through its life. In fact, the “dirt” we see may be evolving as a result of the interactions among the moisture, chemicals, and biological materials found there. Buildings are designed or intended to respond actively to some of these changes in and around them with heating, cooling, ventilating, air cleaning or illuminating systems. We clean, sanitize, and maintain surfaces to enhance their appearance, performance, or longevity. In other cases, such changes subtly or even dramatically alter buildings in ways that may be important to their own integrity or their impact on building occupants through the evolution of the physical, chemical, and biological processes that define them at any time.