According to the United States Census Bureau, the CDP has a total area of , all of it recorded as land. Depauville hamlet is located at the junction of New York State Route 12 and County Roads 11 (Sylvia Street), 12 (Overbluff Road), and 179 (Caroline Street). Route 12 leads north to the village of Clayton on the St. Lawrence River and southeast to Watertown, the county seat. The village is mostly on the south bank of the Chaumont River. Depauville provides community events held at each of two churches, the fire department banquet hall and public library. Depauville also has a small town market and a bar, the Depauville Hotel. The Depauville Hotel is one of many stops for snowmobilers during the winter months as it is a crossroad of snowmobile trails that travel north to Clayton and eventually Gouverneur or west to Chaumont that accesses Lake Ontario. Depauville is a site for hunting and fishing as the salmon spawn and migration includes the Chaumont River from Lake Ontario. Access to the Thousand Islands region is a 10-minute drive northbound on State Route 12. As of the census of 2000, there were 512 people, 178 households, and 137 families residing in the CDP. The population density was 52.3 per square mile (20.2/km2). There were 203 housing units at an average density of 20.7/sq mi (8.0/km2). The racial makeup of the CDP was 99.22% White, 0.39% from other races, and 0.39% from two or more races. Hispanic or Latino of any race were 0.59% of the population. There were 178 households, out of which 44.9% had children under the age of 18 living with them, 60.1% were married couples living together, 12.4% had a female householder with no husband present, and 23.0% were non-families. 17.4% of all households were made up of individuals, and 7.3% had someone living alone who was 65 years of age or older. The average household size was 2.88 and the average family size was 3.27. In the CDP, the population was spread out, with 32.2% under the age of 18, 7.0% from 18 to 24, 32.8% from 25 to 44, 18.9% from 45 to 64, and 9.0% who were 65 years of age or older.