The Giants would go on to win Game 3, 2–1 in 10 innings on a Joaquin Arias ground ball mishandled by Scott Rolen allowing Buster Posey to score the winning run. During Game 2 of the 2012 National League Championship Series in San Francisco, Vogelsong faced Chris Carpenter, with the Cardinals holding a 1–0 series lead. Vogelsong allowed 1 run in the 2nd inning to tie the game, but proceeded to shut out the Cardinals offense through seven innings en route to a 7–1 win at home to tie the series at one game apiece. During Game 6 of the NLCS in San Francisco, Vogelsong and the Giants faced elimination for a fifth time. Giants' pitching had begun to dominate. Vogelsong had a very strong outing this time, scattering five hits and allowing one run (in the 6th inning), after the Giants set the tempo with a four-run 2nd inning to break the game open. He set a new career-high of 9 strikeouts on the night after he struck out Daniel Descalso with a foul tip. The Giants won 6–1, pushing the NLCS to the limit in a magical Game 7, which they won to complete the comeback and advance to the World Series. During Game 3 of the 2012 World Series in Detroit, the Giants held a surprising 2–0 lead for the first time in the 2012 postseason. Vogelsong again had a strong outing, posting a shutout through 5.2 innings. The Tigers threatened to open the scoring with the bases loaded and one out in the 5th inning, but Vogelsong struck out Quintin Berry and got Miguel Cabrera to pop out to end the threat. The Giants would go on to win Game 3, 2–0, and posted the first back-to-back shutouts since 1966. The Giants went on to sweep the Detroit Tigers 4–0 to win the World Series. Vogelsong and Barry Zito were the only pitchers to go undefeated in the postseason amongst all Giants' starting pitchers. Vogelsong posted a 3–0 record with a 1.09 ERA, allowing three runs through 24.2 innings, the lowest ERA among all Giants' starting pitchers. Vogelsong's postseason ERA was the best since Orel Hershiser's 1.05 in 1988 (minimum 24 innings). Vogelsong joined Christy Mathewson as the only pitchers to start their postseason careers with four consecutive starts of five or more innings giving up one run or fewer.