Rucka says Lark intuitively knows what is happening in the story even when it isn't clearly scripted. Rucka and Lark have an ongoing conversation about how to show the injustice in the way Forever is treated without being complicit in it themselves. For example, medics must remove Forever's clothes to treat her wounds. Lark wanted to avoid sexualizing the images, but also avoid being "coy" by simply blocking parts of her body with another character's arm. The script gives Lark no direction for aspects like architecture, clothing, or vehicle design. Designing these technical details involves research into prototype technology and takes almost as long as drawing the actual pages for the comics. The time required to create the sets is the primary reason Lark sometimes falls behind schedule. Lark works on "Lazarus" ten or more hours per day. He uses photo references and digital tools in the early stages of his art, but the layouts and drawing are done with traditional tools. He is more involved with the coloring on "Lazarus" than any other comic he has illustrated. The logo design was finalized by Trautmann and Lark. Lark initially did all the lettering and inking for "Lazarus", but doing so made it impossible to release new issues on a regular schedule. To give him more time to focus on drawing, some of the smaller tasks like logo and type design were given to other people. Brian Level assisted with inking on issues three through ten, when he was replaced by Tyler Boss. Beginning with issue ten, Jodi Wynne took over the lettering duties and Owen Freeman started creating the cover art. Fake advertisements found on the back covers and many of the computer screens and holographic images in the artwork are created by Trautmann. Lark and Rucka often discuss whether to use sound effects in scenes or limit their use. Lark does not want to rely on them to convey information because they may become a "crutch" in place of including important details in the art. Issue fifteen features a silent, thirteen-page fight between two characters. Rucka, who used to be a choreographer, filmed himself acting out the battle with a friend. Lark used the film for reference as he drew. Following the 2016 United States presidential election, the creators' vision for the comic shifted. Rucka, who had used the letter columns in the series to discuss his concerns about then-candidate Donald Trump, told Oregon Public Broadcasting that after the election results "Lazarus" had changed from a dystopian science fiction story to a documentary.