Injury ruled him out of the 2013 Six Nations championship, and seemed to have ruled him out of initial selection for the British and Irish Lions squad for the 2013 British and Irish Lions tour to Australia. However, on 5 June, he replaced Irish prop Cian Healy after Healy was injured during the second tour match against Western Force. Corbisiero started the first Test against Australia on Saturday 22 June. Corbisiero scored the Lions' first try in their victorious third test against Australia which clinched the series. Unforunately, further injuries to shoulder, neck and back dogged his career, and he played only two more international matches, against Argentina in November 2013, then one more appearance two years later, coming off the subs bench against France in August 2015, in a warm-up match for the 2015 World Cup. Recurrent injuries prevented him being part of the World Cup squad. After announcing his intentions in January 2016 to take a year out from Rugby, Corbisiero was an analyst for NBC Sports coverage of the Aviva Premiership alongside with Leigh Diffey. While guest hosting on the Rugby Pod podcast in early 2018 Alex acknowledged it was unlikely he would be returning to professional rugby.