On October 10, 1491, he opted for the suburbicarian see of Palestrina. He participated in the papal conclave of 1492 that elected Pope Alexander VI. On August 31, 1492, the pope named him suburbicarian bishop of Porto e Santa Rufina. When, as part of the Italian War of 1494–1498, French troops entered Rome on May 27, 1495, he and the pope left Rome for Orvieto. He was named (titular) Latin Patriarch of Antioch on January 23, 1497. He died in Rome on April 10, 1503, two days after he was poisoned by his cook on the orders of Cesare Borgia. He is buried in San Marcello al Corso.