Another example for MCR utilizing CuFe2O4 was published in a research towards the A3 coupling of aldehydes, amine with phenylacetylene to give the corresponding propargylamines. The catalyst can be reused three times without remarkable reduce in reaction yield. Pallapothula and coworkers demonstrated CuFe2O4 is an efficient catalyst for C-O cross-coupling between phenols and aryl halides. The catalyst exhibited superior activity in comparison with other nanoparticles oxides such as Co3O4, SnO2, Sb2O3. Moreover, the catalyst can benefit in applying C-O cross-coupling on alkyl alcohols, leading to widening scope for the transformation. Nano CuFe2O4 catalyst was demonstrated its activity for C-H activation in Mannich type reaction. In the mechanistic study, the copper play a significant role in both generate radical from TBHP and activate C-H from substituted alkyne. In this reaction, iron center was considered as a magnetic source and this hypothesis was proved by the experiment, in which magnetic Fe3O4 had been used but failed to catalyze reaction in the absence of copper center. CuFe2O4 can also be applied for C-C cleavage α-arylation between acetylacetone with iodobenzene. The phenylacetone product was obtained with excellent yield at 99% and 95% selectivity observed for principal product compared to 3-phenyl-2,4-pentanedione as the byproduct. The XRD results were observed that crystal structure of catalyst remained unchanged after the sixth run while catalytic activity slightly decreases at 97% conversion in the final run. In this reaction, the mechanistic study showed the catalytic cycle started from CuII to CuI and then oxidized to CuII by aryl iodine. The role of copper has been further emphasized in the coupling reaction of ortho-arylated phenols and dialkylformamides. It was observed that there was a single-electron oxidative addition of copperII to copperIII through a radical step, then transformed back to copperI by reductive elimination in the presence of either oxygen or peroxide. Catalyst can be reused 9 times without significant loss in catalytic activities. Notably, synergistic effect was demonstrated for the case of CuFe2O4 in Sonogashira reaction. Both Fe and Cu center contribute to catalytic activity of the transformation between aryl halide and substituted alkynes.