This was more than twice the highest amount found in the 2009 study. Trace amounts of lead can contaminate raw ingredients, specifically mineral based additives, as this element occurs naturally in soil, water, and air. The Campaign for Safe Cosmetics made a list of chemicals for concern which can contain toxic chemicals such as lead. Whilst only trace amounts of lead are ingested from lipstick, lead accumulates in the body over time, which can eventually lead to lead poisoning. The most common users of lipstick are teens and adult women, and a study performed by the University of California-Berkeley found that women applied lipstick anywhere from two to fourteen times a day. This translates to up to 87 milligrams of product ingestion per day. Lead ingestion is particularly concerning for pregnant women because lead can enter the fetus from the mother. The FDA is the regulating body of cosmetic safety under the U.S. FD&C Act. Cosmetics regulated by the FD&C Act do not need to be approved for pre-market sale, but pre-market approval is required for any color additives used in lipsticks. Currently, the FDA has not set an acceptable lead limit level for lipsticks specifically, but it has set specifications for lead in the color additives used in lipstick. The FDA's maximum lead limit level is 20 parts per million in cosmetics; however, since lipstick is absorbed through the skin and only ingested in very small quantities, the FDA does not "consider the lead levels we found in the lipsticks to be a safety concern". The CDC, on the other hand, reports that there is no safe blood level for lead and that its presence, even at low levels, can affect IQ, the ability to pay attention, and academic achievement. Once present, the effects of lead exposure on the body cannot be reversed. Traces of lipstick, cosmetics, nail polish, or other "smears" could be found left on drinking cups, glasses, cigarette butts, and tissue papers and may all be significant forensic evidence in the investigation of a crime, especially in cases such as sexual assault, homicide, and in government- or corporate-related corruption and controversies. Lipstick, as a physical evidence, may be found on clothing, parts of the victim's or convict's body, a tissue, a cigarette, etc. By comparing the composition of a lipstick smear with that of a victim or a witness, forensic scientists can demonstrate direct or indirect proof of contact or a relationship between the plaintiff and the defendant. Also, it is sometimes possible to extract saliva DNA from the lipstick print which might link a suspect to their presence at the crime scene.