For people with allergies to "Aloe vera", skin reactions may include contact dermatitis with mild redness and itching, difficulty with breathing, or swelling of the face, lips, tongue, or throat. Aloin, a compound found in the semi-liquid latex of some "Aloe" species, was the common ingredient in over-the-counter (OTC) laxative products in the United States until 2002 when the Food and Drug Administration banned it because manufacturers failed to provide the necessary safety data. "Aloe vera" has potential toxicity, with side effects occurring at some dose levels both when ingested or applied topically. Although toxicity may be less when aloin is removed by processing, "Aloe vera" ingested in high amounts may induce side effects, such as abdominal pain, diarrhea or hepatitis. Chronic ingestion of aloe (dose of 1 gram per day) may cause adverse effects, including hematuria, weight loss, and cardiac or kidney disorders. "Aloe vera" juice is marketed to support the health of the digestive system, but there is neither scientific evidence nor regulatory approval to support this claim. The extracts and quantities typically used for such purposes appear to be dose-dependent for toxic effects. "Aloe vera" is used in traditional medicine as a skin treatment. Early records of "Aloe vera" use appear in the Ebers Papyrus from the 16th century BC, and in Dioscorides' "De Materia Medica" and Pliny the Elder's "Natural History" – both written in the mid-first century AD. It is also written of in the "Juliana Anicia Codex" of 512 AD. "Aloe vera" is used on facial tissues where it is promoted as a moisturizer and anti-irritant to reduce chafing of the nose. Cosmetic companies commonly add sap or other derivatives from "Aloe vera" to products such as makeup, tissues, moisturizers, soaps, sunscreens, incense, shaving cream, or shampoos. A review of academic literature notes that its inclusion in many hygiene products is due to its "moisturizing emollient effect". Orally ingested non-decolorized aloe vera leaf extract was listed by the California Office of Environmental Health Hazard Assessment, along with goldenseal, among "chemicals known to the state to cause cancer or reproductive toxicity". Use of topical aloe vera is not associated with significant side effects.