She then appeared in the crime film "Picture Claire" (2001), opposite Gina Gershon, followed by the independent lesbian-themed drama "Gaudi Afternoon" (2001), co-starring with Judy Davis and Lili Taylor. The film received unfavorable reviews, with A. O. Scott of "The New York Times" writing that both Taylor and Lewis "overact like second-string sketch performers on "Saturday Night Live"." Lewis subsequently had a supporting role in the drama "Enough" (2002), playing the friend of a battered woman (played by Jennifer Lopez). Lewis received an Emmy nomination for Outstanding Supporting Actress for her performance in the television film "Hysterical Blindness" (2002), in which starred opposite Uma Thurman and Gena Rowlands as the friend of a woman in 1980s New Jersey who receives a psychiatric diagnosis. Additionally, she received an Independent Spirit Award nomination for Best Supporting Female. Next, Lewis had a supporting role as the lover of an unstable man (Stephen Dorff) terrorizing a family in the thriller "Cold Creek Manor" (2003). She also appeared in the HIM music video for "Buried Alive By Love" in 2003, and had a supporting part in the comedy "Old School". In April 2003, Lewis filed for divorce from husband Berra after approximately three years of marriage. Lewis described the divorce as "amicable," and later commented: "Steve would be the first to admit he was a workaholic. You have to be ready to have a partnership. And sometimes you’re like, 'Whoa, this is too much. I only actually have enough steam to focus on my own thing.'" Beginning in 2003, Lewis embarked on a musical career, forming the rock band Juliette and the Licks with former Hole drummer Patty Schemel. The band released their debut EP, "...Like a Bolt of Lightning", in late 2004 through Fiddler Records. She also appeared as a guest vocalist on three tracks by electronic music group The Prodigy's album "Always Outnumbered, Never Outgunned" (also released in 2004). The same year, Lewis appeared in the comedy film "Starsky & Hutch", playing the role of Kitty, as Reese Feldman's girlfriend, and had a supporting part in the Jan Kounen's French futuristic Western film "Blueberry" opposite Vincent Cassel. She subsequently appeared in the Johnny Knoxville-led comedy "Daltry Calhoun" (2005), playing the girlfriend of a Tennessee entrepreneur, and in the drama "Aurora Borealis" (also 2005), playing the live-in assistant of an elderly couple (played by Donald Sutherland and Louise Fletcher).