She won two singles titles and two doubles titles on ITF Circuit, but fell in the first round once and in WTA singles qualifying four times (incl. Roland Garros, Wimbledon, US Open). Siegemund got to the top 100 in the WTA ranking (finishing No. 90). She reached the quarterfinals at the WTA Tour twice in Florianópolis, Brazil and in Kockelscheuer, Luxembourg. She reached the second round once; fell in the first round four times (incl. Wimbledon and US Open) and in qualifying five times (incl. the other two majors). She won three WTA doubles titles and also won one singles and one doubles title on ITF Circuit. In Wimbledon, she reached her first Grand Slam main draw after exiting ten times in the qualification rounds. At the Australian Open, Siegemund scored one of her biggest victories, defeating former world No. 1 Jelena Janković in the second round in three sets. In April, she made an upset by reaching the final as a qualifier in Stuttgart, losing to compatriot and defending champion Angelique Kerber. On her way to this success she beat three top-10 players in a row (Simona Halep, Roberta Vinci and Agnieszka Radwańska), all of them in straight sets. At the Premier Mandatory tournament in Madrid, she reached as a qualifier the third round. After beating 9th-seed Svetlana Kuznetsova and Mirjana Lučić-Baroni she lost to Sorana Cîrstea. At the French Open and in Wimbledon, she was knocked out in the first round. In July, she won the first WTA title of her career in Båstad, the place where she played her first match on the WTA Tour in 2010. In the final, she defeated Kateřina Siniaková in straight sets. She got to the quarterfinals at the Olympic Games in Rio de Janeiro. In September, she won her first Grand Slam title, winning the US Open mixed-doubles championship with Mate Pavić. After winning only one of nine matches on hardcourt, Siegemund started the clay-court season by reaching the semifinals of the Charleston Open. She won her second career title in her hometown Premier event Stuttgart Open after a wildcard entry, defeating Kristina Mladenovic in the final in three sets.