The KAP1/ KRAB complex then recruits the heterochromatin protein 1 (HP1), and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation. Using the STRING database, two interacting proteins were found to have high confidence interaction scores. High interaction scores are any scores above 0.7. The two proteins are Transcription intermediary factor 1-beta (TRIM28) with a score of 0.903 and Leucine-rich repeat-containing protein 61 (LRRC61) with a score 0.803. A research done by Zaibo Li et. al displayed the KRAB-A-Domain in action. The von-Hippel Lindau tumor suppressor (pVHL) is a part of protein complex known as E3 ubiquitin ligase and targets hypoxia-inducible-factor 1a (HIF-1a) for breakdown. It is reported that there is a new protein that was discovered that interacts with the pVHL protein and helps it with its job. pVHL works by bringing in histone deacetylases, and it is helped by a certain domain on this new protein. It is shown in a study by Li et. al that this domain is the KRAB-A-domain and it mediates pVHL’s transcriptional repression of HIF-1a. Additionally, the research shows that the KRAB-A-domain is shown to repress transcription on top of its ability to recruit histone deacetylases.