Interferon-inducible GTPase 5  Interferon-inducible GTPase 5 also known as immunity-related GTPase cinema 1 (IRGC1) is an enzyme that in humans is coded by the IRGC gene. It is predicted to behave like other proteins in the p47-GTPase-like and IRG families. It is most expressed in the testis. IRGC is located on chromosome 19 at position 19q13.31 and contains two exons. It is on the forward strand and is upstream of Phospholipase A2 Inhibitor and Ly6/PLAUR Domain-Containing Protein-Like (LOC105372412) and downstream of Nonsense Mediated mRNA Decay Factor (SMG9). There is one paralog for IRGC named IRGM. IRGM, or immunity related GTPase M, is associated with intracellular defense. Both are part of the p47-GTPase-like family and the P-loop NTPase domain superfamily. The paralog has 12% identity to IRGC. IRGC was observed to be conserved in all vertebrates. The GTP/Magnesium and polypeptide binding regions and a transmembrane region are fairly conserved between species. IRGC is predicted to have evolved more rapidly than cytochrome c and β-hemoglobin when comparing the percent identity of the same species for each gene over 500 million years. It is likely that IRGC and IRGM diverged 350 to 375 million years ago. There was one promoter region, GXP_311825, found for IRGC on chromosome 19. It is 1521 base pairs long and starts at base pair 43714694. It is conserved on all 7 orthologous sequences tested and has the most association with testis, at 8.090 tpm. Of the six potential transcripts, GXT_26231691 had the most CAGE tags. Testis was labeled on 839 of 873 CAGE tags. The most common transcript for IRGC is 1596 base pairs long and has the accession number NM_019612. Other transcripts include isoform X1, XM_005259058, isoform X2, XM_011527118, and isoform X3, XM_006723283. Interferon-inducible GTPase 5 is 463 amino acids long, has a molecular weight of 50.3 kDa, and a predicted isoelectric point of 5.22.