What therapies are recommended for patients with severe hypercholesterolemia (LDL-C 190 mg/dL [ 4.9 mmol/L])?
Therapies recommended for patients with severe hypercholesterolemia (LDL-C 190 mg/dL [ 4.9 mmol/L]) include maximally tolerated statin therapy, ezetimibe therapy, the addition of a bile acid sequestrant, and the addition of a PCSK9 inhibitor. These therapies are classified by the degree of recommendation and the level of evidence according to the Clinical Practice Guidelines published by the American College of Cardiology and the American Heart Association. Refer to Online Data Supplements 9 and 10 for more information.