What is the appropriate BP threshold for initiating medical therapy for chronic IHD?
The appropriate BP threshold for initiating medical therapy for chronic IHD remains controversial. However, an overview of 17 placebo-controlled trials showed that reducing diastolic BP by 5 to 6 mm Hg (or an estimated 10 to 20 mm Hg in systolic BP) within a population was associated with a significant reduction in vascular mortality, with approximately 40% reduction in stroke and 20% reduction in coronary events.547