What is the impact of clinical statements and guidelines on the risk of arterial ischemic stroke or cerebral sinovenous thrombosis in neonates and children?
A systematic review and meta-analysis of observational studies published in Circulation in 2010 found that carriers of familial thrombophilia, such as those with protein C or protein S deficiencies, have an increased risk of arterial thromboembolic events at a young age. This highlights the importance of clinical statements and guidelines in the diagnosis and management of acute deep vein thrombosis in order to reduce the risk of arterial ischemic stroke or cerebral sinovenous thrombosis in neonates and children.