What effects does ranolazine have on BP and heart rate?
Ranolazine has been found to have minimal effects on mean heart rate (,2 beats per minute) and systolic BP (,3 mm Hg) even at maximal exercise. It does not increase the rate pressure product, regardless of age, diabetes mellitus, reactive airway disease, or heart failure. As such, it is an attractive alternative for patients with bradycardia or low BP, and is currently indicated for the treatment of chronic angina and may be used in combination with other medications. However, further clinical evaluation is needed to assess the effects of ranolazine as part of intensive interventions for multiple risk factors.