What is the risk of stroke associated with transdermal estradiol and oral estrogens?
Transdermal estradiol was not associated with an increased risk of stroke, whereas oral estrogens significantly increased stroke risk. Low-dose products that contained 50 g of estrogen did not increase stroke risk (rate ratio, 0.81; 95% CI, 0.62 1.05) compared with no use, but high-dose patches that contained >50 g did increase risk (rate ratio, 1.89; 95% CI, 1.15 3.11).