What is the role of folate antagonists in the treatment of methicillin-resistant Staphylococcus aureus infection?
Folate antagonists, such as trimethoprim-sulfamethoxazole, have been used to treat Staphylococcus aureus infections, including methicillin-resistant S. aureus (MRSA). Studies have suggested that trimethoprim-sulfamethoxazole may be more effective than vancomycin in treating S. aureus infections in some cases. However, its use is limited due to its potential side effects. Additionally, folate antagonists can be used in combination with other antibiotics to improve the efficacy of treatment regimens for MRSA infections.