What are the effects of high dose ACEI and low dose ACEI on patients with CKD without DM?
A number of randomized controlled trials (RCTs) have been conducted to examine the effects of high dose ACEI versus low dose ACEI in patients with CKD without DM. Supplementary Tables 17 and 18 provide evidence profiles and RCT results of categorical and continuous outcomes respectively. The results show that high dose ACEI can lead to a decrease in systolic and diastolic blood pressure, a reduction in proteinuria, and improved renal function and serum creatinine concentrations. There were also significant reductions in the incidence of major adverse cardiovascular events, all-cause mortality, and hospitalizations due to heart failure. However, there were no significant differences between the high and low dose ACEI groups in terms of changes in estimated glomerular filtration rate or albuminuria. Overall, the results suggest that high dose ACEI may be beneficial for patients with CKD without DM.  