What is the difference between EPA and DHA treatment?
EPA is an ester derivative of eicosapentae- noic acid (EPA), while DHA is docosahexaenoic acid (DHA). EPA is used in the REDUCE-IT trial, which had a 25% reduction in the primary end point, while EPA/DHA was used in the STRENGTH and OMEMI trials and resulted in lower median blood EPA levels than treatment with IPE. EPA and DHA also have differing effects on membrane stabilization, which may account for the lack of effect with EPA/DHA compared with EPA alone or IPE.