What effect did the Steno-2 Study have on the risk of stroke in patients with type 2 diabetes mellitus and persistent microalbuminuria?
The Steno-2 Study found that intensive therapy, including behavioral risk factor modification and the use of a statin, an ACEI, an ARB, or an antiplatelet drug as appropriate, reduced the risk of stroke from 30 to 6 in patients with type 2 diabetes mellitus and persistent microalbuminuria. In addition, intensive therapy was associated with a 57% lower risk of death from cardiovascular causes (HR, 0.43; 95% CI, 0.19 0.94; P=0.04). Eighteen of the 30 strokes were fatal in the conventional group, and all 6 were fatal in the intensive group.