What was the cost effectiveness of IV iron supplementation based on the clinical evidence of CONFIRM-HF with a different dosing regime and longer follow-up?
The committee noted that all-cause hospitalisation event rates in CONFIRM-HF were similar to those of FAIR-HF. The mean total dose in CONFIRM-HF trial was 1500mg over 1 year, and the unit cost per milligram of iron is the same between the 100mg and 500mg vial sizes. The 500mg dosing regime (as in CONFIRM-HF) requires significantly fewer visits than the 200mg dosing regime and is therefore less costly. The committee also noted that such a regime is likely to be more acceptable to people due to the fewer number of visits. This has led the committee to consider the cost effectiveness of IV iron supplementation based on the clinical evidence of CONFIRM-HF with a different dosing regime and longer follow-up.