6/28/23, 11:22 PM NSABP B-32 Pathway Feedback Search Clinical Topics Home Studies NSABP B 32 NSABP B 32 Trial question What is the role of sentinel lymph node resection in women with invasive breast cancer and clinically negative lymph nodes? Study design Multi-center Open label RCT Population 5611 female patients Inclusion criteria: women with invasive breast cancer and clinically negative lymph nodes Key exclusion criteria: age < 18 years, positive ipsilateral axillary lymph nodes or prior removal of ipsilateral axillary lymph nodes, ulceration, erythema, infiltration of the skin or underlying chest wall, prior or concurrent breast implants, or prior breast malignancy Interventions N=1975 routine axillary node dissection (sentinel node resection with axillary dissection) N=2011 selective axillary node dissection (sentinel node resection with axillary dissection only if SLNs were positive) Primary outcome Overall survival, as per log-rank comparison 96.4 % 96.4 95 72.3 % 48.2 % 24.1 % No significant difference 0.0 % Routine axillary node dissection Selective axillary node dissection No significant difference in overall survival, as per log-rank comparison (96.4% vs. 95%; HR 1.2, 95% CI 0.96 to 1.5) Conclusion https://web.pathway.md/studies/rec6qeeKHWbkh4dgm 1/2 6/28/23, 11:22 PM NSABP B-32 Pathway In women with invasive breast cancer and clinically negative lymph nodes, routine axillary node dissection was not superior to selective axillary node dissection with respect to overall survival, as per log-rank comparison. Reference Krag DN, Anderson SJ, Julian TB et al. Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B-32 randomised phase 3 trial. Lancet Oncol. 2010 Oct;11(10):927-33. Open reference URL https://web.pathway.md/studies/rec6qeeKHWbkh4dgm 2/2