6/28/23, 11:16 PM MOMENTUM 3 Pathway Feedback Search Clinical Topics Home Studies MOMENTUM 3 MOMENTUM 3 Disease Heart failure Trial question Is magnetically levitated centrifugal continuous-flow circulatory pump superior to mechanical- bearing axial continuous-flow pump in patients with advanced HF? Study design Multi-center Open label RCT Population Characteristics of study participants 20.0% female N = 366 80.0% male 366 patients (73 female, 293 male) Inclusion criteria: patients with advanced HF that was refractory to guideline-mandated medical management Key exclusion criteria: active infection, irreversible end-organ dysfunction, or expected use of biventricular circulatory support Interventions N=190 centrifugal-flow pump LVAD (HeartMate3 fully magnetically levitated centrifugal continuous-flow pump) N=176 axial-flow pump LVAD (HeartMate II mechanical-bearing axial continuous-flow pump) https://web.pathway.md/studies/recahvRvxtpZVZK7R 1/2 6/28/23, 11:16 PM MOMENTUM 3 Pathway Primary outcome Survival free of disabling stroke at 2 years 79.5 % 79.5 59.6 % 60.2 39.8 % Significant increase 19.9 % NNT = 5 0.0 % Centrifugal-flow pump LVAD Axial-flow pump LVAD Significant increase in survival free of disabling stroke at 2 years (79.5% vs. 60.2%; HR 2.17, 95% CI 1.44 to 3.22) Secondary outcomes Significant decrease in reoperation for pump malfunction (1.6% vs. 17%; HR 0.08, 95% CI 0.03 to 0.27) Significant decrease in pump thrombosis (1.1% vs. 15.7%; HR 0.06, 95% CI 0.01 to 0.26) Significant decrease in stroke (10.1% vs. 19.2%; HR 0.47, 95% CI 0.27 to 0.84) Safety outcomes No significant differences in hemorrhagic stroke, right HF, surgical and nonsurgical bleeding, and infection. Conclusion In patients with advanced HF that was refractory to guideline-mandated medical management, centrifugal-flow pump LVAD was superior to axial-flow pump LVAD with respect to survival free of disabling stroke at 2 years. Reference Mehra MR, Goldstein DJ, Uriel N et al. Two-Year Outcomes with a Magnetically Levitated Cardiac Pump in Heart Failure. N Engl J Med. 2018 Apr 12;378(15):1386-1395. Open reference URL https://web.pathway.md/studies/recahvRvxtpZVZK7R 2/2