6/29/23, 1:44 AM PRIMA Pathway Feedback Search Clinical Topics Home Studies PRIMA PRIMA Trial question What's the effect of adding timing and coordination training to a standard strength and endurance training in community-dwelling older adults? Study design Multi-center Open label RCT Population Characteristics of study participants 65.0% female N = 249 35.0% male 249 patients (163 female, 86 male) Inclusion criteria: ambulatory adults 65 years of age with gait speed of 0.60-1.20 m/s and physical clearance to exercise Key exclusion criteria: dyspnea at rest or during activities; unstable medical condition; dementia or cognitive impairment; history of stroke; plans to leave the area during the study period Interventions N=124 standard-plus program (standard program plus task-specific timing and coordination training) N=125 standard program (physical therapist-supervised strength, endurance, and flexibility program for 50-60 min twice/week for 12 weeks) Primary outcome Mean improvement in gait speed at 12 weeks 0.1 m/s 0.081 0.079 0.1 m/s 0.0 m/s https://web.pathway.md/studies/recXmUurgAYuTj3mZ 1/2 6/29/23, 1:44 AM PRIMA Pathway 0 0 /s 0.0 m/s No significant difference 0.0 m/s Standard-plus program Standard program No significant difference in mean improvement in gait speed at 12 weeks (0.079 m/s vs. 0.081 m/s; MD 0.001, 95% CI -0.02 to 0.02) Secondary outcomes No significant difference in mean improvement in gait speed at 36 weeks (0.059 m/s vs. 0.065 m/s; MD -0.003, 95% CI -0.04 to 0.03) No significant difference in mean improvement in lower extremity strength at 24 weeks (-2.2 N vs. 2 N; MD -4.9, 95% CI -14.09 to 4.29) No significant difference in mean improvement in 6 minute walk distance at 24 weeks (31.8 m vs. 20.6 m; MD 7.3, 95% CI -12.1 to 26.7) Safety outcomes No significant difference in serious adverse events. Conclusion In ambulatory adults 65 years of age with gait speed of 0.60-1.20 m/s and physical clearance to exercise, standard-plus program was not superior to standard program with respect to mean improvement in gait speed at 12 weeks. Reference Jennifer S Brach, Subashan Perera, Valerie Shuman et al. Effect of Timing and Coordination Training on Mobility and Physical Activity Among Community-Dwelling Older Adults: A Randomized Clinical Trial. JAMA Netw Open. 2022 May 2;5(5):e2212921. Open reference URL https://web.pathway.md/studies/recXmUurgAYuTj3mZ 2/2