6/29/23, 11:41 PM SEPSISPAM Pathway Feedback Search Clinical Topics Home Studies SEPSISPAM SEPSISPAM Disease Sepsis and septic shock Trial question What is the role of high blood-pressure target in patients with septic shock? Study design Multi-center Open label RCT Population Characteristics of study participants 33.0% female N = 776 67.0% male 776 patients (259 female, 517 male) Inclusion criteria: patients with septic shock Key exclusion criteria: legal protection (i.e., incompetence to provide consent and no guardian or incarceration), pregnancy, recent participation in another biomedical study or another interventional study with mortality as the primary end point, or an investigator's decision not to resuscitate Interventions N=388 high-target (mean arterial pressure target of 80-85 mmHg) N=388 low-target (mean arterial pressure target of 65-70 mmHg) Primary outcome https://web.pathway.md/studies/rec8grxZnrJmduGWd 1/2 6/29/23, 11:42 PM SEPSISPAM Pathway Death at 28 days 36.6 % 36.6 34 27.5 % 18.3 % 9.2 % No significant difference 0.0 % High-target Low-target No significant difference in death at 28 days (36.6% vs. 34%; HR 1.07, 95% CI 0.84 to 1.38) Secondary outcomes No significant difference in death at 90 days (43.8% vs. 42.3%; HR 1.04, 95% CI 0.83 to 1.3) Safety outcomes No significant differences in serious adverse events (19.1% vs. 17.8%, p=0.64). Significant differences in newly diagnosed AF (6.7% vs. 2.8%, p = 0.02). Conclusion In patients with septic shock, high-target was not superior to low-target with respect to death at 28 days. Reference Asfar P, Meziani F, Hamel JF et al. High versus low blood-pressure target in patients with septic shock. N Engl J Med. 2014 Apr 24;370(17):1583-93. Open reference URL https://web.pathway.md/studies/rec8grxZnrJmduGWd 2/2