What potential risks of hormone replacement therapy (HT) have been seen in other trials?
Potentially harmful effects of HT have been seen in other trials, such as the WHI, which could include an increase in stroke, VTE, or breast cancer in treated women. Additionally, a nested case-control study examining patients in general practices in the United Kingdom found that oral estrogens significantly increased stroke risk, while transdermal estradiol did not increase risk. However, high-dose patches that contained over 50 g of estrogen did increase stroke risk.