What are the various LMWHs approved for use in Europe, Canada, and the United States?
The various LMWHs approved for use in Europe, Canada, and the United States include enoxaparin (Lovenox), tinzaparin (Innohep), dalteparin (Fragmin), and reviparin (Clivarine). These drugs have a mean molecular weight of 4,000 to 5,000 which corresponds to about 15 saccharide units and a range of 2,000 to 9,000. They are prepared using different methods of depolymerization and differ in their pharmacokinetic properties, anticoagulant profiles, and recommended dosing regimens.