What is the benefit of clopidogrel 75 mg compared with aspirin 325 mg in patients with previous MI, stroke, or symptomatic PAD?
Clopidogrel 75 mg has been compared with aspirin 325 mg in patients with previous MI, stroke, or symptomatic PAD in the prospective, randomized CAPRIE (Clopidogrel versus Aspirin in Patients at Risk of Ischaemic Events) study. Although clopidogrel demonstrated superiority over aspirin in the secondary prevention of MI and death in this group of patients, the magnitude of difference was small.