What is the effect of B vitamin supplementation on secondary stroke risk?
Results from VITATOPS (Vitamins to Prevent and VISP (Vitamin Intervention for Stroke Prevention) did not show a significant reduction in risk of secondary stroke among patients with recent stroke who were randomized to receive various doses of folic acid and vitamin B supplementation. However, it remains unknown whether folic acid or vitamin B supplementation in a specific subgroup of patients with recent stroke or TIA may be beneficial in reducing the risk of secondary stroke. Randomized trials of B vitamins for secondary stroke prevention are needed in patients with stroke or TIA who do not consume folate-fortified foods.