What is the recommendation for patients who cannot tolerate a statin?
The Work Group decided upon a Weak against recommendation. A direct study evaluating the comparative effectiveness and safety of treating to reach specific LDL-C or non-HDL-C goals versus the use of a fixed-dose statin and based on initial CV risk assessment is needed. Recommendation 23. For patients who cannot tolerate a statin, we suggest a washout period followed by a re- challenge with the same or a different statin or lower dose, and if that fails, a trial of intermittent (nondaily) dosing. (Weak for | Reviewed, New-added)