6/30/23, 2:17 AM TNT Pathway Feedback Search Clinical Topics Home Studies TNT TNT Disease Disease Coronary artery disease Dyslipidemia Trial question Is 80 mg atorvastatin superior to 10 mg atorvastatin in patients with stable coronary disease and LDL cholesterol levels of < 130 mg/dL? Study design Multi-center Double blinded RCT Population Characteristics of study participants 19.0% female N = 10001 81.0% male 10001 patients (1902 female, 8099 male) Inclusion criteria: patients with stable coronary disease and LDL cholesterol levels of < 130 mg/dL Key exclusion criteria: hypersensitivity to statins; active liver disease or hepatic dysfunction; pregnant or breastfeeding women; nephrotic syndrome; uncontrolled diabetes mellitus; uncontrolled hypothyroidism; or uncontrolled hypertension Interventions N=4995 high-dose atorvastatin (80 mg of atorvastatin) N=5006 low-dose atorvastatin (10 mg of atorvastatin) Primary outcome https://web.pathway.md/studies/recw13EEFzbOERu7Z 1/2 6/30/23, 2:17 AM TNT Pathway Major cardiovascular events 10.9 % 10.9 8.7 8.2 % 5.5 % Significant decrease 2.7 % NNT = 45 0.0 % High-dose atorvastatin Low-dose atorvastatin Significant decrease in major cardiovascular events (8.7% vs. 10.9%; HR 0.78, 95% CI 0.69 to 0.89) Secondary outcomes Significant decrease in major coronary events (6.7% vs. 8.3%; HR 0.8, 95% CI 0.69 to 0.92) No significant difference in death from any cause (5.7% vs. 5.6%; HR 1.01, 95% CI 0.85 to 1.19) Significant decrease in cerebrovascular event (3.9% vs. 5%; HR 0.77, 95% CI 0.64 to 0.93) Safety outcomes Significant differences in adverse events (8.1% vs. 5.8%, p < 0.001), including persistent elevations in liver aminotransferase levels (1.2% vs. 0.2%, p < 0.001). Conclusion In patients with stable coronary disease and LDL cholesterol levels of < 130 mg/dL, high-dose atorvastatin was superior to low-dose atorvastatin with respect to major cardiovascular events. Reference LaRosa JC, Grundy SM, Waters DD et al. Intensive lipid lowering with atorvastatin in patients with stable coronary disease. N Engl J Med. 2005 Apr 7;352(14):1425-35. Open reference URL https://web.pathway.md/studies/recw13EEFzbOERu7Z 2/2