What were the results of the Steno-2 study regarding risk reduction of cardiovascular disease in patients with type 2 diabetes?
The Steno-2 study reported a reduced risk of CVD in patients with type 2 diabetes mellitus who participated in an intensive, multifactorial intervention that included quarterly clinic visits; a low-fat diet; 30 minutes of exercise 3 to 5 times/wk; prescription of an ACE inhibitor, a multivitamin, and aspirin; and a step-wise approach to pharmacological therapy for diabetes mellitus, hypertension, and hyperlipidemia. After a mean follow-up of 7.8 years, the intensive therapy group experienced a significant risk reduction in a combined end point that included cardiovascular mortality, nonfatal MI, coronary artery bypass surgery, percutaneous coronary intervention, nonfatal stroke, amputation, or vascular surgery for peripheral P=0.008). 