What is the best way to manage severe or life-threatening hypertriglyceridemia during pregnancy?
Clinicians should consider conditions specific to women, such as premature menopause (age <40 years) and history of pregnancy-associated disorders (hypertension, preeclampsia, gestational diabetes mellitus, small-for-gestational-age infants, preterm deliveries) when discussing lifestyle intervention and the potential for benefit of statin therapy. Women of childbearing age who are treated with statin therapy and are sexually active should be counseled to use a reliable form of contraception. Women of childbearing age with hypercholesterolemia who plan to become pregnant should stop the statin 1 to 2 months before pregnancy is attempted, or if they become pregnant while on a statin, should have the statin stopped as soon as the pregnancy is discovered.