What are the risks of long-term use of DAPT with aspirin and clopidogrel for recurrent stroke prevention?
Long-term use of DAPT with aspirin and clopidogrel has been shown in two secondary stroke clinical statements and guidelines to have no benefit over SAPT for recurrent stroke prevention and to have a significantly increased risk of ICH and major bleeding. The exact duration of DAPT at which the risk of hemorrhage begins to outweigh the benefit of stroke prevention is unknown, but meta-analyses report as early as 21,802 or and those with more appear to be at higher risk of ICH with DAPT.