What is the quality of the evidence from the ADVANCE study of patients with CKD G1-G3?
The quality of evidence from the ADVANCE study of patients with CKD G1-G3 is low according to GRADE. The quality of the evidence was downgraded due to serious risk of bias, with unclear allocation concealment, and imprecision, as the beneficial results of diuretics were seen only in the CKD subgroups, when the results were negative in the entire cohort (Supplementary Table S27).