6/30/23, 2:22 AM TTH48 Pathway Feedback Search Clinical Topics Home Studies TTH48 TTH48 Disease Cardiac arrest Trial question What is the role of prolonged targeted temperature management in survivors of out-of-hospital cardiac arrest? Study design Multi-center Open label RCT Population Characteristics of study participants 10.0% female N = 79 90.0% male 79 patients (8 female, 71 male) Inclusion criteria: out-of-hospital cardiac arrest survivors with perceived good cognitive outcome Key exclusion criteria: out-of-hospital cardiac arrest of suspected origin other than cardiac, in- hospital cardiac arrest, terminal disease, coagulation disorders, unwitnessed asystolia Interventions N=43 TTM48 (prolonged target temperature management for 48 hours) N=36 TTM24 (standard targeted temperature management for 24 hours) Primary outcome Cognitive impairment at 6 months https://web.pathway.md/studies/recL5DTR2NnIoMzmZ 1/2 6/30/23, 2:22 AM TTH48 Pathway 33.0 % 33 24.8 % 16.5 % Significant increase 12 8.3 % NNH = 5 0.0 % TTM48 TTM24 Significant increase in cognitive impairment at 6 months (12% vs. 33%; RR 2.9, 95% CI 1.1 to 7.4) Safety outcomes No significant differences in attention, executive function. Conclusion In out-of-hospital cardiac arrest survivors with perceived good cognitive outcome, TTM48 was superior to TTM24 with respect to cognitive impairment at 6 months. Reference Lars Evald, Kolbj rn Br nnick, Christophe Henri Valdemar Duez et al. Prolonged targeted temperature management reduces memory retrieval deficits six months post-cardiac arrest: A randomised controlled trial. Resuscitation. 2019 Jan;134:1-9. Open reference URL https://web.pathway.md/studies/recL5DTR2NnIoMzmZ 2/2