What markers of atrial dysfunction are most strongly associated with recurrent stroke risk?
A post-hoc subgroup analysis of subjects with ESUS enrolled in the SOCRATES trial found that left atrial diameter >4.6 cm was associated with a benefit from anticoagulation. However, PFO (patent foramen ovale) was not found to be associated with a benefit from anticoagulation. Additionally, markers of atrial dysfunction such as atrial fibrillation, left atrial enlargement, left atrial dysfunction, and left ventricular hypertrophy have been suggested as potential risk factors for recurrent stroke risk in ESUS. More research is needed to determine which markers of atrial dysfunction are most strongly associated with recurrent stroke risk.