What is the risk benefit ratio associated with aggressive BP control in certain subgroups?
The risk benefit ratio associated with aggressive BP control in certain subgroups may differ depending on the subpopulation. It may be higher in individuals who are prone to dehydration and are at risk of AKI. The 2016 European Society of Hypertension guideline recommends targeting the 75th percentile of MAP of normal children in a CKD patient with no proteinuria, and the 50th percentile if an individual has proteinuria. This is based on a subgroup analysis of the ESCAPE data, which suggested that those children with a PCR <0.5 g/g (50 mg/ mmol) did not have a significant benefit from strict BP control.