What is the limitation of the studies comparing routine invasive strategy and selective invasive strategy in patients with unstable coronary syndromes?
One limitation of these studies is the absence of adherence to optimal medical therapy in non-invasively treated patients during long-term management. In addition, in FRISC-II, invasive management was delayed and patients with markedly positive stress tests (up to 2.9-mm exercise-induced ST depression) were randomized to noninvasive or invasive therapy.