What should be done to lower the temperature in a patient with stroke?
Antipyretic medications should be administered to lower temperature in hyperthermic patients with stroke. This recommendation is unchanged from the 2013 AIS Guidelines and is supported by a large retrospective cohort study conducted from 2005 to 2013 of patients admitted to intensive care units in Australia, New Zealand, and the United Kingdom. Peak temperature in the first 24 hours <37 C and >39 C was associated with an increased risk of in-hospital death compared with normothermia in 9366 patients with AIS. See Tables XXXI and XXXII in online Data Supplement 1.