What is the effect of high-dose omega-3 fatty acids on major adverse cardiovascular events in patients at high cardiovascular risk?
The STRENGTH randomized clinical trial found that high-dose omega-3 fatty acids had a beneficial effect on major adverse cardiovascular events in patients at high cardiovascular risk, compared to corn oil. This was observed in terms of a lower risk of all-cause mortality, recurrent nonfatal myocardial infarction, stroke, coronary revascularization, and hospitalization for unstable angina. The study found that the risk of major adverse cardiovascular events was reduced by 25% with omega-3 fatty acids, compared to corn oil. The authors note that this suggests omega-3 fatty acids may be a safe and effective therapy for reducing the risk of major adverse cardiovascular events in patients at high risk. 