6/29/23, 1:42 AM PREVENT Pathway Feedback Search Clinical Topics Home Studies PREVENT PREVENT Disease Deep vein thrombosis Trial question What is the role of adjunctive intermittent pneumatic compression in critically ill patients receiving pharmacologic thromboprophylaxis? Study design Multi-center Open label RCT Population Characteristics of study participants 43.0% female N = 2003 57.0% male 2003 patients (855 female, 1148 male) Inclusion criteria: adults patients within 48 hours after admission to an ICU Key exclusion criteria: ICU admittance > 48 hours, contraindications to pharmacologic thromboprophylaxis, inability or contraindication to applying intermittent pneumatic compression to both legs Interventions N=991 pneumatic compression (intermittent pneumatic compression for at least 18 hours each day plus pharmacologic thromboprophylaxis) N=1012 control (pharmacologic thromboprophylaxis with unfractionated or low-molecular-weight heparin alone) https://web.pathway.md/studies/rec0js2kV7GquyEQH 1/2 6/29/23, 1:42 AM PREVENT Pathway Primary outcome Incident proximal deep vein thrombosis 4.2 % 4.2 3.9 3.2 % 2.1 % 1.1 % No significant difference 0.0 % Pneumatic compression Control No significant difference in incident proximal deep vein thrombosis (3.9% vs. 4.2%; RR 0.93, 95% CI 0.6 to 1.44) Secondary outcomes No significant difference in VTE (10.4%% vs. 9.4%%; RR 1.11, 95% CI 0.85 to 1.44) No significant difference in lower-limb deep vein thrombosis, PE, or death from any cause at 28 days (23.3% vs. 24%; RR 0.97, 95% CI 0.83 to 1.14) No significant difference in death from any cause at 90 days (26.1% vs. 26.7%; RR 0.98, 95% CI 0.84 to 1.13) Safety outcomes No significant differences in lower limb skin injury, limb ischemia. Conclusion In adults patients within 48 hours after admission to an ICU, pneumatic compression was not superior to control with respect to incident proximal deep vein thrombosis. Reference Yaseen M Arabi, Fahad Al-Hameed, Karen E A Burns et al. Adjunctive Intermittent Pneumatic Compression for Venous Thromboprophylaxis. N Engl J Med. 2019 Apr 4;380(14):1305-1315. Open reference URL https://web.pathway.md/studies/rec0js2kV7GquyEQH 2/2