What is the association between ACE-Is and kidney failure?
ACE-Is were associated with a HR of 0.69 for kidney failure (95% CI 0.51 0.94) and 0.70 for the combined outcome of doubling of the baseline SCr concentration or kidney failure (95% CI 0.55 0.88). Patients with greater urinary protein excretion at baseline benefited more from ACE-I therapy (P 0.03 for kidney failure and P 0.001 for the combined outcome).