What are the effects of protamine on low molecular weight heparin?
Protamine has been shown to partially reverse the anti-Xa activity of low molecular weight heparin (LMW heparin). Studies have demonstrated that protamine can reduce the anti-Xa activity of LMW heparin in both in vitro and in vivo settings, resulting in decreased anticoagulant effect. In addition, protamine has been shown to affect the clotting and complement factors associated with LMW heparin, resulting in decreased anticoagulant activity.