What evidence supports the Mediterranean Diet for the reduction of CVD events in individuals with high cardiovascular risk?
The PREDIMED trial (Prevención con Dieta Mediterránea) provides evidence of a reduction in stroke events in individuals with high cardiovascular risk. The primary end point (MI, stroke, or cardiovascular death) identified adjusted HRs of 0.72 (95% CI, 0.54 0.95) for the Mediterranean diet with olive oil supplementation and 0.69 (95% CI, 0.53 0.91) with nut supplementation compared with the control diet. Additionally, the Lyon Diet Heart trial of the Mediterranean diet with supplemental canola compared with a usual post-MI prudent diet, producing low-quality evidence of reduced CVD mortality and total mortality (adjusted HR, 0.21 0.92], respectively) in a coronary heart.