What evidence suggests that adjusting the intensity of anticoagulant therapy is beneficial for stroke prevention?
Studies such as the J-ROCKET AF study (Hori et al., 2013) and the Japanese Nonvalvular Atrial Fibrillation-Embolism Secondary Prevention Cooperative Study Group (Yamaguchi, 2000) have shown that adjusting the intensity of anticoagulant therapy can lead to better outcomes in terms of stroke severity and mortality. Additionally, systematic reviews and meta-analyses such as the one conducted by Oake et al. (2008) have found that higher intensity anticoagulation therapy is associated with lower risk of adverse events such as intracranial hemorrhage and thromboembolism. Furthermore, studies such as the one conducted by Fitzmaurice et al. (2016) have shown that better control of anticoagulation intensity leads to better outcomes in terms of stroke prevention. 