What is the evidence regarding statin use in patients with ICH?
Evidence regarding statin use in patients with ICH is conflicting. The Stroke Prevention With Aggressive Reduction in Cholesterol Levels (SPARCL) study found that the benefit of high-dose atorvastatin in reducing recurrent ischemic stroke was offset in part by an increased risk of ICH. However, a meta-analysis of 31 randomized controlled trials that included 91 588 statin-treated patients found no significant association between statin use and ICH, and all-cause mortality was significantly reduced with statin use.