6/30/23, 2:20 AM TRICC Pathway Feedback Search Clinical Topics Home Studies TRICC TRICC Disease Transfusion strategies in critical Trial question Is restrictive strategy of transfusion superior to liberal strategy in critically ill patients with euvolemia who had Hgb concentrations < 9.0 g/dL within 72 hours after admission to ICU? Study design Multi-center Single blinded RCT Population Characteristics of study participants 37.0% female N = 838 63.0% male 838 patients (314 female, 524 male) Inclusion criteria: critically ill patients with euvolemia who had Hgb concentrations < 9.0 g/dL within 72 hours after admission to ICU Key exclusion criteria: age < 16 years; inability to receive blood products; active blood loss at the time of enrollment ,chronic anemia; pregnancy; brain death or imminent death Interventions N=418 restrictive blood transfusion therapy (transfusion when Hgb concentration < 7.0 g/dL, Hgb concentrations maintained at 7.0-9.0 g/dL) N=420 liberal blood transfusion therapy (transfusion when Hgb concentration < 10.0 g/dL, Hgb concentration maintained at 10.0-12.0 g/dL) https://web.pathway.md/studies/recUBPNL3FHnamUfN 1/2 6/30/23, 2:20 AM TRICC Pathway Primary outcome Death at 30 days 23.3 % 23.3 18.7 17.5 % 11.7 % 5.8 % No significant difference 0.0 % Restrictive blood transfusion therapy Liberal blood transfusion therapy No significant difference in death at 30 days (18.7% vs. 23.3%; AD 4.7%, 95% CI -0.84 to 10.2) Secondary outcomes Significant decrease in death at 30 days among patients with APACHE II score 20 (8.7% vs. 16.1%; RR 0.54, 95% CI 1 to 13.6) No significant difference in death in the hospital (22.3% vs. 28.1%; AD 5.8%, 95% CI -0.3 to 11.7) No significant difference in length of stay in the hospital (34.8 days vs. 35.5 days; AD 0.7 days, 95% CI -1.9 to 3.4) Safety outcomes No significant differences in rates of cardiac events, infectious complications, multiorgan failure. Significant differences in pulmonary edema (5.3% vs. 10.7%), myocardial infarction (0.7% vs. 2.9%). Conclusion In critically ill patients with euvolemia who had Hgb concentrations < 9.0 g/dL within 72 hours after admission to ICU, restrictive blood transfusion therapy was not superior to liberal blood transfusion therapy with respect to death at 30 days. Reference Hebert PC, Wells G, Blajchman MA et al. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. N Engl J Med. 1999 Feb 11;340(6):409-17. Open reference URL https://web.pathway.md/studies/recUBPNL3FHnamUfN 2/2