6/28/23, 10:12 PM Early liver transplantation for severe alcoholic hepatitis Pathway Feedback Search Clinical Topics Home Studies Early liver transplantation for severe alcoholic hepatitis Early liver transplantation for severe alcoholic hepatitis Disease Disease Disease Alcohol-related liver disease Alcoholic hepatitis Liver tr Trial question What is the role of early liver transplantation in patients with severe alcoholic hepatitis? Study design Multi-center Open label RCT Population Characteristics of study participants 42.0% female N = 52 58.0% male 52 patients (22 female, 30 male) Inclusion criteria: patients with no prior episodes of alcoholic hepatitis and had scores of 0.45 according to the Lille model Key exclusion criteria: uncontrolled infection, recent gastrointestinal bleeding, positive for hepatitis B, HCV and HIV antibodies, and severe psychiatric disorders Interventions N=26 undergoing early liver transplantation (early liver transplantation within a median of 13 days after nonresponse to medical therapy) N=26 not undergoing liver transplantation (matched patients who did not undergo transplantation) Primary outcome Cumulative survival at 6 months 77.0 % 77 https://web.pathway.md/studies/recHa3qasoSKfglXz 1/2 6/28/23, 10:12 PM Early liver transplantation for severe alcoholic hepatitis Pathway 57.8 % 38.5 % Significant increase 23 19.3 % NNT = 2 0.0 % Undergoing early liver transplantation Not undergoing liver transplantation Significant increase in cumulative survival at 6 months (77% vs. 23%; RR 3.35, 95% CI 1.36 to 5.34) Secondary outcomes Significant increase in survival at 2 year follow-up, in univariate analysis (71% vs. 23%; RR 3.09, 95% CI 1.26 to 4.92) Conclusion In patients with no prior episodes of alcoholic hepatitis and had scores of 0.45 according to the Lille model, undergoing early liver transplantation was superior to not undergoing liver transplantation with respect to cumulative survival at 6 months. Reference Mathurin P, Moreno C, Samuel D et al. Early liver transplantation for severe alcoholic hepatitis. N Engl J Med. 2011 Nov 10;365(19):1790-800. Open reference URL https://web.pathway.md/studies/recHa3qasoSKfglXz 2/2