What is the quality of evidence for the relative effect of intravenous iron compared to oral iron in treating heart failure?
The quality of evidence for the relative effect of intravenous iron compared to oral iron in treating heart failure is VERY LOW, due to risk of bias, imprecision, indirectness, and heterogeneity (I2 =51%). It is downgraded by 1 increment if the majority of the evidence was at high risk of bias, and downgraded by 2 increments if the majority of the evidence was at very high risk of bias. It is downgraded by 1 increment if the confidence interval crossed 1 MID or by 2 increments if the confidence interval crossed both MIDs, and is downgraded by 1 increment as the outcome is indirect.