6/28/23, 12:38 AM AMETIS Pathway Feedback Search Clinical Topics Home Studies AMETIS AMETIS Disease Acute ischemic stroke Trial question Is general anesthesia with tracheal intubation superior to procedural sedation in patients treated with mechanical thrombectomy for anterior circulation acute ischemic stroke? Study design Multi-center Open label RCT Population Characteristics of study participants 52.0% female N = 273 48.0% male 273 patients (142 female, 131 male) Inclusion criteria: adult patients treated with mechanical thrombectomy for anterior circulation acute ischemic stroke Key exclusion criteria: coma or altered vigilance; premorbid disability Interventions N=135 general anesthesia (general anesthesia with tracheal intubation) N=138 procedural sedation (sedation with spontaneous ventilation, targeting minimal to moderate sedation level) Primary outcome https://web.pathway.md/studies/rechwjwQlIfw64JsY 1/2 6/28/23, 12:38 AM AMETIS Pathway Functional independence at day 90 and absence of major periprocedural complications at day 7 36.2 % 36.2 28.2 27.2 % 18.1 % 9.1 % No significant difference 0.0 % General anesthesia Procedural sedation No significant difference in functional independence at day 90 and absence of major periprocedural complications at day 7 (28.2% vs. 36.2%; ARD -8.1, 95% CI -19.1 to 2.3) Secondary outcomes No significant difference in procedure-related serious adverse events (6.7% vs. 3.6%; AD 3%, 95% CI -2.1 to 8.2) No significant difference in excellent recovery at day 90 (14.8% vs. 18.8%; ARD -4, 95% CI -13 to 5) No significant difference in death at day 90 (18.5% vs. 16.7%; AD 2%, 95% CI -7 to 11) Conclusion In adult patients treated with mechanical thrombectomy for anterior circulation acute ischemic stroke, general anesthesia was not superior to procedural sedation with respect to functional independence at day 90 and absence of major periprocedural complications at day 7. Reference Russell Chabanne, Thomas Geeraerts, Marc Begard et al. Outcomes After Endovascular Therapy With Procedural Sedation vs General Anesthesia in Patients With Acute Ischemic Stroke: The AMETIS Randomized Clinical Trial. JAMA Neurol. 2023 Apr 3;e230413. Open reference URL https://web.pathway.md/studies/rechwjwQlIfw64JsY 2/2