What is the scope of the International Collaboration on Endocarditis (ICE) Prospective Cohort Study?
The International Collaboration on Endocarditis Prospective Cohort Study (ICE-PCS) is a large-scale, multi-center, prospective observational study that aims to provide insight into the clinical presentation, etiology, and outcomes of infective endocarditis (IE) in the 21st century. The ICE-PCS involves over 200 centers from 24 countries and has enrolled over 2,000 patients since its inception in 2008. The study aims to provide a comprehensive evaluation of clinical, microbiologic, and epidemiologic characteristics of IE, as well as to identify risk factors for poor outcomes and to develop evidence-based guidelines for effective management of IE.  