6/28/23, 11:02 PM Low-dose dopamine in patients with early renal dysfunction Pathway Feedback Search Clinical Topics Home Studies Low-dose dopamine in patients with early renal dysfunction Low-dose dopamine in patients with early renal dysfunction Disease Acute kidney injury Trial question What is the role of low-dose dopamine in critically ill patients at risk of renal failure? Study design Multi-center Double blinded RCT Population Characteristics of study participants 39.4% female N = 328 60.6% male 328 patients (128 female, 196 male) Inclusion criteria: critically ill patients at risk of renal failure Key exclusion criteria: age < 18 years; an episode of acute renal failure within the previous 3 months; previous renal transplantation; use of dopamine at any dose during the current hospital stay; and unsuitability for use of RRT Interventions N=161 low-dose dopamine (2 g/kg/min through central venous catheter while in the ICU) N=163 placebo (matching placebo through central venous catheter while in the ICU) Primary outcome Peak serum creatinine concentration https://web.pathway.md/studies/recx3uLgfTY0LDdhq 1/2 6/28/23, 11:02 PM Low-dose dopamine in patients with early renal dysfunction Pathway 249.0 249 245 186.8 124.5 62.3 No significant difference 0.0 Low-dose dopamine Placebo No significant difference in peak serum creatinine concentration (245 vs. 249; difference 4, 95% CI -28 to 36) Secondary outcomes No significant difference in requirement of RRT (35 vs. 40; difference 5, 95% CI -10 to 20) Conclusion In critically ill patients at risk of renal failure, low-dose dopamine was not superior to placebo with respect to peak serum creatinine concentration. Reference Bellomo R, Chapman M, Finfer S et al. Low-dose dopamine in patients with early renal dysfunction: a placebo-controlled randomised trial. Australian and New Zealand Intensive Care Society (ANZICS) Clinical Trials Group. Lancet. 2000 Dec 23-30;356(9248):2139-43. Open reference URL https://web.pathway.md/studies/recx3uLgfTY0LDdhq 2/2