What are the outcomes following pre-operative clopidogrel administration in patients with acute coronary syndromes undergoing coronary artery bypass surgery?
The outcome of pre-operative clopidogrel administration in patients with acute coronary syndromes undergoing coronary artery bypass surgery has been studied in the ACUITY (Acute Catheterization and Urgent Intervention Triage strategY) trial. The results of the trial showed that patients who were pre-treated with clopidogrel had a lower risk of major adverse cardiovascular events, but a higher risk of major bleeding compared to those who were not pre-treated with clopidogrel. In addition, the use of clopidogrel was associated with a reduction in mortality and a decrease in the need for transfusions.