6/30/23, 2:20 AM TREATY Pathway Feedback Search Clinical Topics Home Studies TREATY TREATY Disease Obesity Trial question Is a regimen of time-restricted with calorie restriction superior to calorie restriction only in patients with obesity? Study design Single center Open label RCT Population Characteristics of study participants 49.0% female N = 139 51.0% male 139 patients (68 female, 71 male) Inclusion criteria: adult patients with obesity Key exclusion criteria: acute or chronic viral hepatitis; malignant tumors; serious cardiovascular or cerebrovascular disease; type 1 and T2DM; serious liver dysfunction; CKD Interventions N=69 time-restricted eating (eating only between 8:00 am and 4:00 pm with calorie restriction) N=70 daily calorie restriction (continuous energy restriction without a restriction of feeding time) Primary outcome Reduction in body weight at 1 year https://web.pathway.md/studies/recwlXbPMJWWUEf85 1/2 6/30/23, 2:20 AM TREATY Pathway 8.0 kg 8 6.3 6.0 kg 4.0 kg 2.0 kg No significant difference 0.0 kg Time-restricted eating Daily calorie restriction No significant difference in reduction in body weight at 1 year (8 kg vs. 6.3 kg; AD 1.8 kg, 95% CI -0.4 to 4) Secondary outcomes No significant difference in reduction in BMI at 1 year (2.9 vs. 2.3; AD 0.7, 95% CI -0.1 to 1.5) No significant difference in reduction in waist circumference at 1 year (8.8 cm vs. 7 cm; AD 1.8 cm, 95% CI -0.5 to 4) No significant difference in reduction in body fat mass at 1 year (5.9 kg vs. 4.5 kg; AD 1.5 kg, 95% CI -0.2 to 3.1) Safety outcomes No significant difference in adverse events. Conclusion In adult patients with obesity, time-restricted eating was not superior to daily calorie restriction with respect to reduction in body weight at 1 year. Reference Deying Liu, Yan Huang, Chensihan Huang et al. Calorie Restriction with or without Time-Restricted Eating in Weight Loss. N Engl J Med. 2022 Apr 21;386(16):1495-1504. Open reference URL https://web.pathway.md/studies/recwlXbPMJWWUEf85 2/2