6/29/23, 12:42 AM RABBIT 2 Pathway Feedback Search Clinical Topics Home Studies RABBIT 2 RABBIT 2 Disease Disease Diabetes mellitus type 2 In-hospital hyperglycemia Trial question What is the effect of basal-bolus insulin therapy in the management of non-critically ill, hospitalized patients with T2DM? Study design Multi-center Open label RCT Population Characteristics of study participants 52.0% female N = 130 48.0% male 130 patients (67 female, 63 male) Inclusion criteria: non-critically ill, hospitalized patients with T2DM who are insulin-naive Key exclusion criteria: without a known history of diabetes, ICU patients, the use of corticosteroid therapy, expected to undergo surgery during the hospitalization course, clinically relevant hepatic disease, serum creatinine 3.0 mg/dl, or pregnancy Interventions N=65 use of a basal-bolus insulin regimen (glargine once daily and glulisine before meals at a starting dose of 0.4 units x kg(-1) x day(-1) for blood glucose 140-200 mg/dl or 0.5 units x kg(-1) x day(-1) for blood glucose 201-400 mg/dl) https://web.pathway.md/studies/recnUFXg8hIupargn 1/2 6/29/23, 12:42 AM RABBIT 2 Pathway N=65 use of a standard sliding-scale insulin protocol (sliding-scale regular insulin four times per day for blood glucose > 140 mg/dL) Primary outcome Percentage of patients achieving mean glucose target of < 140 mg/dL 66.0 % 66 49.5 % 38 33.0 % Significant increase 16.5 % NNT = 4 0.0 % Use of a basal-bolus insulin regimen Use of a standard sliding-scale insulin protocol Significant increase in the percentage of patients achieving mean glucose target of < 140 mg/dL (66% vs. 38%; RR 1.74, 95% CI 0.42 to 3.06) Conclusion In non-critically ill, hospitalized patients with T2DM who are insulin-naive, use of a basal-bolus insulin regimen was superior to use of a standard sliding-scale insulin protocol with respect to the percentage of patients achieving mean glucose target of < 140 mg/dL. Reference Umpierrez GE, Smiley D, Zisman A et al. Randomized study of basal-bolus insulin therapy in the inpatient management of patients with type 2 diabetes (RABBIT 2 trial). Diabetes Care. 2007 Sep;30(9):2181-6. Open reference URL https://web.pathway.md/studies/recnUFXg8hIupargn 2/2