6/28/23, 11:16 PM MATCH Pathway Feedback Search Clinical Topics Home Studies MATCH MATCH Disease Disease Acute ischemic stroke Transient ischemic attack Trial question What is the role of aspirin and clopidogrel in high-risk patients with recent ischemic stroke or TIA? Study design Multi-center Double blinded RCT Population Characteristics of study participants 37.0% female N = 7599 63.0% male 7599 patients (2821 female, 4778 male) Inclusion criteria: high-risk patients with recent ischemic stroke or TIA and at least one additional vascular risk factor who were already receiving clopidogrel 75 mg/day Key exclusion criteria: age < 40 years, severe comorbid conditions, increased risk of bleeding, scheduled for major surgery or vascular surgery, and contraindications for aspirin or clopidogrel Interventions N=3797 aspirin (75 mg/day) N=3802 placebo (matching placebo daily) Primary outcome Ischemic stroke, myocardial infarction, vascular death, or rehospitalization for acute ischemia https://web.pathway.md/studies/recrcdxje9kNK2G2M 1/2 6/28/23, 11:16 PM MATCH Pathway 16.7 % 16.7 15.7 12.5 % 8.3 % 4.2 % No significant difference 0.0 % Aspirin Placebo No significant difference in ischemic stroke, myocardial infarction, vascular death, or rehospitalization for acute ischemia (15.7% vs. 16.7%; RR 0.94, 95% CI 0.84 to 1.05) Secondary outcomes No significant difference in myocardial infarction, ischemic stroke, or vascular death (12% vs. 12%; RR 0.94, 95% CI 0.83 to 1.07) No significant difference in death from any cause (5% vs. 5%; RR 0.99, 99% CI 0.79 to 1.18) Safety outcomes Significant difference in life-threatening bleedings (2.6% vs. 1.3%) and major bleeds (1.12% vs. 0.29%). Conclusion In high-risk patients with recent ischemic stroke or TIA and at least one additional vascular risk factor who were already receiving clopidogrel 75 mg/day, aspirin was not superior to placebo with respect to ischemic stroke, myocardial infarction, vascular death, or rehospitalization for acute ischemia. Reference Diener HC, Bogousslavsky J, Brass LM et al. Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial. Lancet. 2004 Jul 24-30;364(9431):331-7. Open reference URL https://web.pathway.md/studies/recrcdxje9kNK2G2M 2/2