In people with suspected heart failure, what thresholds of pro-B-type natriuretic peptide (NT-proBNP) and B- type natriuretic peptide (BNP) are most accurate in identifying heart failure (as indicated by the reference standard)?
The diagnostic accuracy of BNP and NT-proBNP can be determined through 2x2 tables that measure the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV), as well as a receiver operating characteristic (ROC) curve or area under the curve (AUC).