What is the role of oral anticoagulation in patients with rheumatic mitral valve disease without AF and no other likely cause for their symptoms?
In patients with rheumatic mitral valve disease without AF and no other likely cause for their symptoms (eg, carotid stenosis), the role of oral anticoagulation has not been adequately investigated. Further larger studies are needed to determine whether oral anticoagulation with warfarin or a DOAC improves outcomes.