What are the potential side effects of Fondaparinux?
Fondaparinux has low af nity for PF4 and does not cross-react with HIT antibodies.203 Although there have been isolated case reports of HIT associated with the use of fondaparinux204,205 and reports of HIT antibodies without thrombocytopenia in patients given prophylaxis with fondaparinux,206 numerous case reports and case series suggest that this agent can be used to treat patients with HIT.207 This issue is further discussed in the article on HIT by Linkins et al32 in this supplement and has been summarized by Blackmer et al.208 Additionally, drug accumulation can occur in patients with renal insuf- ciency, and anaphylaxis and thrombotic events have also been reported as potential side effects of Fondaparinux.