What was the risk of major bleeding in patients with severe renal insufficiency (CrCl < 30 mL/min) given LMWH?
In 12 studies involving 4,971 patients given LMWH, the OR for major bleeding was 2.25 (95% CI, 1.19-4.27) in patients with a CrCl < 30 mL/min compared with that in those with a CrCl > 30 mL/min. Enoxaparin at a therapeutic dose was associated with a further increase in major bleeding in patients (95% CI, 1.78-8.45), but this was not observed when enoxaparin was empirically dose reduced (0.9%).