6/30/23, 2:22 AM TTM2 Pathway Feedback Search Clinical Topics Home Studies TTM2 TTM2 Disease Cardiac arrest Trial question Is hypothermia superior to normothermia in patients with coma after out-of-hospital cardiac arrest? Study design Multi-center Open label RCT Population Characteristics of study participants 21.0% female N = 1861 79.0% male 1861 patients (384 female, 1477 male) Inclusion criteria: adults with coma who had an out-of-hospital cardiac arrest Key exclusion criteria: Interval from ROSC to screening of > 180 minutes; unwitnessed cardiac arrest with asystole as the initial rhythm; limitations in care Interventions N=930 hypothermia (targeted temperature of 33 Celsius) N=931 normothermia (targeted temperature 37.5 Celsius with early treatment of fever) Primary outcome Death from any cause at 6 months 50 50 0 % 48 https://web.pathway.md/studies/recYTqEBxnKU1tM6r 1/2 6/30/23, 2:22 AM 50.0 % TTM2 Pathway 50 48 37.5 % 25.0 % 12.5 % No significant difference 0.0 % Hypothermia Normothermia No significant difference in death from any cause at 6 months (50% vs. 48%; RR 1.04, 95% CI 0.94 to 1.14) Secondary outcomes No significant difference in the percentage of patients with moderately severe disability or worse at 6 months (55% vs. 55%; RR 1, 95% CI 0.92 to 1.09) No significant difference in the percentage of patients with poor functional outcome at 6 months (54% vs. 54%; RR 1, 95% CI 0.91 to 1.08) No significant difference in health-related quality of life in participants who survived to 6 months (74 vs. 75; MD -0.8, 95% CI -3.6 to 2) Safety outcomes No significant differences in bleeding, pneumonia, sepsis. Significant difference in arrhythmias resulting in hemodynamic compromise (24% vs. 17%). Conclusion In adults with coma who had an out-of-hospital cardiac arrest, hypothermia was not superior to normothermia with respect to death from any cause at 6 months. Reference Josef Dankiewicz, Tobias Cronberg, Gisela Lilja et al. Hypothermia versus Normothermia after Out- of-Hospital Cardiac Arrest. N Engl J Med. 2021 Jun 17;384(24):2283-2294. Open reference URL https://web.pathway.md/studies/recYTqEBxnKU1tM6r 2/2