What diagnostic tests should be considered before administering intravenous alteplase for treatment of acute ischemic stroke?
The assessment of blood glucose must precede the initiation of IV alteplase in all patients. Other tests, for example, international normalized ratio, activated partial thromboplastin time, and platelet count, may be necessary in some circumstances if there is suspicion of coagulopathy. Baseline electrocardiographic assessment is recommended in patients presenting with AIS but should not delay initiation of IV alteplase.