What is the estimated reduction in LDL-C for different statin medications?
The percent reductions for LDL-C for different statin medications are estimated from data across large populations. For primary statin medications (Atorvastatin, Rosuvastatin, and Simvastatin), the median reduction in LDL-C from the VOYAGER database was estimated to be 40%. For other statin medications (Fluvastatin, Lovastatin, Pitavastatin, and Pravastatin), reductions in LDL-C were identified according to FDA-approved product labeling in adults with hyperlipidemia, primary hypercholesterolemia, and Boldface type indicates specific statins and doses that were evaluated in RCTs. These RCTs demonstrated a reduction in major cardiovascular events.