What is the recommended antithrombotic therapy for patients with a stroke or TIA caused by 50% to 99% stenosis of a major intracranial artery?
Aspirin 325 mg/d is recommended in preference to warfarin to reduce the risk of recurrent ischemic stroke and vascular death. In addition, the addition of clopidogrel 75 mg/d to aspirin for up to 90 days is reasonable to further reduce recurrent stroke risk. Ticagrelor 90 mg twice a day to aspirin for up to 30 days might also be considered to further reduce recurrent stroke risk. Cilostazol 200 mg/day to aspirin or clopidogrel might also be considered to reduce recurrent stroke risk.