6/28/23, 11:06 PM HYPERION Pathway Feedback Search Clinical Topics Home Studies HYPERION HYPERION Disease Cardiac arrest Trial question What is the role of moderate therapeutic hypothermia in patients with cardiac arrest who have non-shockable rhythm? Study design Multi-center Open label RCT Population Characteristics of study participants 36.0% female N = 584 64.0% male 584 patients (208 female, 373 male) Inclusion criteria: patients with coma who had been admitted to the ICU after resuscitation from cardiac arrest with non-shockable rhythm Key exclusion criteria: a no-flow time of > 10 minutes; a low-flow time of > 60 minutes; major hemodynamic instability; time from cardiac arrest to a screening of > 300 minutes; moribund condition; severe hepatic dysfunction Interventions N=284 hypothermia (induction of a body temperature of 33 C with a window of +- 0.5 degree Celsius and maintained for 24 hours) N=297 normothermia (body temperature maintained at 36.5 to 37.5 C for 48 hours according to the standard protocol) Primary outcome https://web.pathway.md/studies/rec7k8Ua4aXAjauUx 1/2 6/28/23, 11:06 PM HYPERION Pathway Rate of survival with a favorable neurologic outcome, Cerebral Performance Category of 1 or 2, on day 90 10.2 % 10.2 7.6 % 5.7 5.1 % Significant increase 2.5 % NNT = 22 0.0 % Hypothermia Normothermia Significant increase in the rate of survival with a favorable neurologic outcome, Cerebral Performance Category of 1 or 2, on day 90 (10.2% vs. 5.7%; AD 4.5%, 95% CI 0.1 to 8.9) Secondary outcomes No significant difference in death at day 90 (81.3% vs. 83.2%; ARD -1.9, 95% CI -8 to 4.3) No significant difference in survival to ICU discharge (21.8% vs. 20.5%; HR 1.07, 95% CI 0.75 to 1.52) No significant difference in survival to hospital discharge (19.7% vs. 16.8%; HR 1.19, 95% CI 0.81 to 1.74) Safety outcomes No significant difference in prespecified serious adverse events. Conclusion In patients with coma who had been admitted to the ICU after resuscitation from cardiac arrest with non-shockable rhythm, hypothermia was superior to normothermia with respect to the rate of survival with a favorable neurologic outcome, Cerebral Performance Category of 1 or 2, on day 90. Reference Jean-Baptiste Lascarrou, Hamid Merdji, Am lie Le Gouge et al. Targeted Temperature Management for Cardiac Arrest with Nonshockable Rhythm. N Engl J Med. 2019 Dec 12;381(24):2327-2337. Open reference URL https://web.pathway.md/studies/rec7k8Ua4aXAjauUx 2/2