What are the potential benefits of reducing sodium intake in people with CKD?
Recent meta-analyses of RCTs in non-CKD populations demonstrate a graded benefit in both BP and CV disease risk reduction with reductions in sodium intake. In CKD populations, this recommendation is driven by short-term studies of moderate-quality evidence evaluating SBP and DBP, but not CV events, as endpoints. Potassium-containing salt substitutes differ from foods rich in potassium, as such foods may have other health benefits, thus extrapolating data from potassium intake in the diet may not be informative to potassium-containing salt substitutes.