What is the effect of proton pump inhibitors on the antiplatelet action of clopidogrel associated with aspirin?
Studies have shown that the use of proton pump inhibitors with clopidogrel and aspirin is associated with decreased efficacy of the antiplatelet action of clopidogrel. This is due to the fact that proton pump inhibitors can inhibit the metabolization of clopidogrel, leading to lower levels of the active metabolite of clopidogrel in the blood. Furthermore, a number of studies have shown that the use of proton pump inhibitors with clopidogrel and aspirin is associated with an increased risk of adverse outcomes, such as stent thrombosis and cardiovascular events. Therefore, it is recommended that proton pump inhibitors should be avoided when taking clopidogrel in combination with aspirin. 