What is the impact of heparin on von Willebrand factor-dependent platelet function?
Research has shown that heparin can inhibit von Willebrand factor-dependent platelet function both in vitro and in vivo. This was demonstrated in a study conducted by Sobel et al. (1991), which found that heparin can reduce the maximal platelet aggregation induced by von Willebrand factor. However, the effects of heparin on platelet function vary depending on the dose and type of heparin used. Thus, further research is needed to determine the optimal dosing and type of heparin for inhibiting von Willebrand factor-dependent platelet function.