6/28/23, 11:37 PM INTERACT2 Pathway Feedback Search Clinical Topics Home Studies INTERACT2 INTERACT2 Disease Intracerebral hemorrhage Trial question What is the role of intensive lowering of elevated BP in patients with intracerebral hemorrhage? Study design Multi-center Open label RCT Population Characteristics of study participants 37.0% female N = 2829 63.0% male 2829 patients (1049 female, 1780 male) Inclusion criteria: patients who had had a spontaneous intracerebral hemorrhage within the previous 6 hours and who had elevated systolic BP Key exclusion criteria: structural cerebral cause for the intracerebral hemorrhage; deep coma; massive hematoma with a poor prognosis; planned early surgery to evacuate the hematoma Interventions N=1399 intensive blood-pressure lowering (target systolic level <140 mm Hg within 1 hour) N=1430 guideline-recommended BP lowering (target systolic level <180 mm Hg) Primary outcome Death or major disability at day 90 55.6 % 55.6 52 41.7 % https://web.pathway.md/studies/reck7zbuoltGFwxpG 1/2 6/28/23, 11:37 PM INTERACT2 Pathway 27.8 % 13.9 % No significant difference 0.0 % Intensive blood-pressure lowering Guideline-recommended blood pressure lowering No significant difference in death or major disability at day 90 (52% vs. 55.6%; OR 0.87, 95% CI 0.75 to 1.01) Secondary outcomes No significant difference in death (11.9% vs. 12%; OR 0.99, 99% CI 0.79 to 1.25) No significant difference in problems with mobility (63.8% vs. 66.7%; OR 0.88, 95% CI 0.74 to 1.04) Safety outcomes No significant differences in nonfatal serious adverse events, neurologic deterioration in first 24 hours. Conclusion In patients who had had a spontaneous intracerebral hemorrhage within the previous 6 hours and who had elevated systolic BP, intensive blood-pressure lowering was not superior to guideline-recommended BP lowering with respect to death or major disability at day 90. Reference Craig S Anderson, Emma Heeley, Yining Huang et al. Rapid blood-pressure lowering in patients with acute intracerebral hemorrhage. N Engl J Med. 2013 Jun 20;368(25):2355-65. Open reference URL https://web.pathway.md/studies/reck7zbuoltGFwxpG 2/2