6/28/23, 10:12 PM Early palliative care for metastatic NSLC Pathway Feedback Search Clinical Topics Home Studies Early palliative care for metastatic NSLC Early palliative care for metastatic NSLC Disease Non-small cell lung cancer Trial question What is the effect of early palliative care in patients with metastatic non-small cell lung cancer? Study design Single center Open label RCT Population Characteristics of study participants 52.0% female N = 151 48.0% male 151 patients (78 female, 73 male) Inclusion criteria: patients with newly diagnosed metastatic non-small cell lung cancer, within 8 weeks after diagnosis Key exclusion criteria: patients already receiving care from palliative care service, ECOG performance status > 2, and not able to read and respond to questions in English Interventions N=77 early palliative care (early palliative care integrated with standard oncologic care) N=74 standard oncologic care (no routine early palliative care) Primary outcome FACT-L quality of life scores at 12 weeks 98.0 98 91.5 73.5 https://web.pathway.md/studies/recWvKApMB1OxiscS 1/2 6/28/23, 10:12 PM Early palliative care for metastatic NSLC Pathway 49.0 24.5 Significant increase 0.0 Early palliative care Standard oncologic care Significant increase in FACT-L quality of life scores at 12 weeks (98 vs. 91.5; MD 6.5, 95% CI 0.5 to 12.4) Secondary outcomes Significant decrease in depression at 12 weeks, as assessed by Hospital Anxiety and Depression Scale (16% vs. 38%; RR 0.42, 95% CI 0.1 to 0.74) Significant increase in median survival (11.6 vs. 8.9; MD 2.7, 95% CI 0.42 to 4.98) Conclusion In patients with newly diagnosed metastatic non-small cell lung cancer, within 8 weeks after diagnosis, early palliative care was superior to standard oncologic care with respect to a FACT-L quality of life scores at 12 weeks. Reference Temel JS, Greer JA, Muzikansky A et al. Early palliative care for patients with metastatic non- small-cell lung cancer. N Engl J Med. 2010 Aug 19;363(8):733-42. Open reference URL https://web.pathway.md/studies/recWvKApMB1OxiscS 2/2