6/29/23, 1:44 AM PneumA Pathway Feedback Search Clinical Topics Home Studies PneumA PneumA Disease Ventilator-associated pneumonia Trial question What is the role of 8 days of antibiotic therapy in adults with ventilator-associated pneumonia ? Study design Multi-center Double blinded RCT Population Characteristics of study participants 28.0% female N = 401 72.0% male 401 patients (112 female, 289 male) Inclusion criteria: patients with ventilator-associated pneumonia by quantitative culture results of bronchoscopic specimens and who had received initial appropriate empirical antimicrobial therapy Key exclusion criteria: pregnancy, little chance of survival, neutropenia, concomitant stage 3 AIDS, or immunosuppression or long-term corticosteroid therapy Interventions N=197 antibiotic treatment for 8 days (8 days of antibiotic therapy) N=204 antibiotic treatment for 15 days (15 days of antibiotic therapy) Primary outcome Death at 28 days https://web.pathway.md/studies/recfB5N16EQLCTW4T 1/2 6/29/23, 1:45 AM PneumA Pathway 18.8 % 18.8 17.2 14.1 % 9.4 % 4.7 % No significant difference 0.0 % Antibiotic treatment for 8 days Antibiotic treatment for 15 days No significant difference in death at 28 days (18.8% vs. 17.2%; ARD 1.6, 90% CI -3.7 to 6.9) Secondary outcomes No significant difference in recurrent infections (28.9% vs. 26%; difference 2.9, 90% CI -3.2 to 9.1) Significant increase in mean (SD) antibiotic-free days (13.1 days vs. 8.7 days; MD 4.4, 95% CI 3.1 to 5.6) Significant increase in recurrent pulmonary infection (40.6% vs. 25.4%; MD 15.2, 90% CI 0.04 to 0.27) Conclusion In patients with ventilator-associated pneumonia by quantitative culture results of bronchoscopic specimens and who had received initial appropriate empirical antimicrobial therapy, antibiotic treatment for 8 days were not superior to antibiotic treatment for 15 days with respect to death at 28 days. Reference Chastre J, Wolff M, Fagon JY et al. Comparison of 8 vs 15 days of antibiotic therapy for ventilator- associated pneumonia in adults: a randomized trial. JAMA. 2003 Nov 19;290(19):2588-98. Open reference URL https://web.pathway.md/studies/recfB5N16EQLCTW4T 2/2