What are the long-term effects of intensive SBP lowering on the kidney?
The long-term effects of intensive SBP lowering on the kidney cannot be determined from these relatively short-term, on-treatment observations. The difference in the rate of decline of eGFR in SPRINT after the initial 6 months was small (0.47 /yr in the intensive and standard arms, respectively). If this slope persisted long-term, it would take 20 years to cause a 3 ml/min per 1.73 m2 difference in eGFR between intensive and standard SBP treatment. Taking both the beneficial effect on albuminuria and the adverse effect on eGFR into account, the long-term effects of intensive SBP lowering on the kidney cannot be determined from these relatively short-term, on-treatment observations.