What are the potential fetal and neonatal effects of treatment with angiotensin-converting enzyme inhibitors in pregnancy?
Research has suggested that fetal and neonatal effects of treatment with angiotensin-converting enzyme inhibitors in pregnancy can include ACE inhibitor fetopathy, hypocalvaria (reduced bone formation in the skull), and renal toxicity. These effects are described in detail in the studies by Barr and Cohen (1991), Hanssens et al. (1991), Buttar (1997), Pryde et al. (1993), and Chobanian et al. (2003). 