What did the WHS study find in regards to the association between migraine with aura and ischemic stroke?
The WHS found that increased frequency in patients with migraine with aura increases ischemic stroke risk and that this increased risk is more pronounced in the absence of typical migraine features. In a separate analysis of the WHS, the association of migraine with aura and ischemic stroke was found to be more pronounced in the absence (HR, 3.27; 95% CI, 1.93 5.51) than in the presence. After a mean follow-up of 11.9 years, multivariable-adjusted analysis found that high migraine frequency (more than weekly) had an increased association with ischemic stroke (HR, 2.77; 95% CI, 1.03 7.46) but not in lower frequencies.