What thresholds of pro-B-type natriuretic peptide (NT-proBNP) and B-type natriuretic peptide (BNP) are most accurate in identifying heart failure?
The diagnostic threshold of NT-proBNP for heart failure in community settings should be revised, and the most accurate thresholds of NT-proBNP and BNP for diagnosing heart failure are not yet established. However, some studies have suggested that NT-proBNP levels of less than 300 ng/L can be used to rule out HFREF, and levels greater than 500 ng/L can be used to rule in HFREF. For BNP, levels greater than 100 ng/L can be used to rule in HFREF, and levels less than 50 ng/L can be used to rule out HFREF.