What were the findings of the ADVANCE study regarding diuretic therapy for lowering BP?
The ADVANCE study found that treatment with a combination of an ACEi plus diuretic (perindopril plus indapamide) was associated with a 9% reduction in the relative risk of a major macrovascular or microvascular event, an 18% reduction in the relative risk of death from CV disease, and a 14% reduction in the relative risk of death from any cause. The treatment was also associated with a fall in BP of SBP 5.3/DBP 2.1 mm Hg in patients with CKD G1 or G2, and SBP 4.5/DBP 1.8 mm Hg in patients with CKD G3 G5. There was no effect modification by the presence of baseline albuminuria.  