What are the effects of oral iron on people with HFREF and iron deficiency?
Oral iron for people with HFREF and iron deficiency appeared to show a clinically important increase in mortality. In terms of adverse events, there was no evidence of a clinically important effect. Oral iron appeared to show a clinically important improvement in NYHA class, which may be suggestive of an overall improvement in the severity of CHF symptoms in these patients. However, the width of the confidence intervals reduced the committee's ability to interpret this result. Oral iron showed a marginal increase in peak VO2 max and a relative decrease in distance walked in the 6-minute walk test. However, these results were reported as median and interquartile range and therefore could not be assessed for imprecision.