What is the relationship between the hemorrhagic and antithrombotic properties of Low Molecular Weight Heparin (LMWH) in rabbits?
The relationship between the hemorrhagic and antithrombotic properties of LMWH in rabbits was studied by Carter et al. (1982). The study found that the antithrombotic effect of LMWH increased with increasing dose, but the hemorrhagic effect increased only to a certain level before plateauing, demonstrating a relationship between the two properties. This suggested that a relatively low dose of LMWH could be used to achieve a desired antithrombotic effect without inducing excessive hemorrhage.