6/28/23, 11:00 PM LIGHTMind Pathway Feedback Search Clinical Topics Home Studies LIGHTMind LIGHTMind Disease Disease Anxiety and depression in patien Major depressive disorder Trial question Is practitioner-supported mindfulness-based cognitive therapy self-help superior to practitioner- supported CBT self-help in adults with depression? Study design Multi-center Single blinded RCT Population Characteristics of study participants 62.0% female N = 410 38.0% male 410 patients (255 female, 155 male) Inclusion criteria: adults experiencing mild-to-moderate depression Key exclusion criteria: 20 points on the PHQ-9 screening; a score of 4 on the clinical interview schedule-revised suicidality scale; strong preference for one intervention over the other Interventions N=204 mindfulness-based cognitive therapy self-help (receipt of a copy of mindfulness-based cognitive therapy self-help workbook and 6 support sessions with a trained practitioner) N=206 CBT self-help (receipt of a copy of CBT self-help workbook and 6 support sessions with a trained practitioner) https://web.pathway.md/studies/rec3kbZy531SbbSrT 1/2 6/28/23, 11:00 PM LIGHTMind Pathway Primary outcome Patient health questionnaire score at 16 weeks post-randomization 8.6 8.6 7.2 6.4 4.3 2.1 Significant decrease 0.0 Mindfulness-based cognitive therapy self-help Cognitive behavioral therapy self-help Significant decrease in patient health questionnaire score at 16 weeks post-randomization (7.2 vs. 8.6; AD -1.5, 95% CI -2.6 to -0.4) Secondary outcomes Significant decrease in GAD 7-item scale score at 16 weeks (5.9 vs. 7; AD -0.95, 95% CI -1.88 to -0.01) No significant difference in short warwick-edinburgh mental well-being scale at 16 weeks (15.7 vs. 15.1; AD 0.97, 95% CI -0.05 to 1.99) No significant difference in work and social adjustment scale score at 16 weeks (11.8 vs. 12.7; AD -1.39, 95% CI -3.05 to 0.28) Conclusion In adults experiencing mild-to-moderate depression, mindfulness-based cognitive therapy self-help was superior to CBT self-help with respect to patient health questionnaire score at 16 weeks post- randomization. Reference Clara Strauss, Anna-Marie Bibby-Jones, Fergal Jones et al. Clinical Effectiveness and Cost- Effectiveness of Supported Mindfulness-Based Cognitive Therapy Self-help Compared With Supported Cognitive Behavioral Therapy Self-help for Adults Experiencing Depression: The Low- Intensity Guided Help Through Mindfulness (LIGHTMind) Randomized Clinical Trial. JAMA Psychiatry. 2023 Mar 22;e230222. Open reference URL https://web.pathway.md/studies/rec3kbZy531SbbSrT 2/2