What is the efficacy of statins in familial hypercholesterolemia?
The efficacy of statins in familial hypercholesterolemia has been demonstrated in a long term cohort study (Versmissen et al., 2008) as well as in the West of Scotland Coronary Prevention Study Group (Shepherd et al., 1995), which found that pravastatin significantly reduced the incidence of coronary heart disease in men with hypercholesterolemia. Furthermore, Khera et al. (2016) showed that sequencing familial hypercholesterolemia genes in patients with severe hypercholesterolemia had a high diagnostic yield and clinical utility. Additionally, Nanchen et al. (2016) found that patients with familial hypercholesterolemia had a good prognosis after experiencing acute coronary syndromes. Lastly, Perak et al. (2016) showed that US adults with the familial hypercholesterolemia phenotype had a long-term risk of atherosclerotic cardiovascular disease.  