6/29/23, 12:44 AM RE-ENERGIZE Pathway Feedback Search Clinical Topics Home Studies RE ENERGIZE RE ENERGIZE Disease Burn injury Trial question What is the role of supplemental glutamine in patients with severe burns? Study design Multi-center Double blinded RCT Population Characteristics of study participants 26.0% female N = 1200 74.0% male 1200 patients (312 female, 888 male) Inclusion criteria: patients with deep second or third degree burns within 72 hours after hospital admission Key exclusion criteria: lack of consent in < 72 hours; moribund state; contraindication to enteral nutrition Interventions N=596 glutamine (0.5 g/kg/day mixed with water given via nasogastric or feeding tube every 4 hours or 3 or 4 times a day by mouth) N=604 placebo (maltodextrin mixed with water given via nasogastric or feeding tube every 4 hours or 3 or 4 times a day by mouth) https://web.pathway.md/studies/recDJ5alYD2qS6uJu 1/2 6/29/23, 12:44 AM RE-ENERGIZE Pathway Primary outcome Time to discharge alive from hospital 40.0 days 40 38 30.0 days 20.0 days 10.0 days No significant difference 0.0 days Glutamine Placebo No significant difference in time to discharge alive from hospital (40 days vs. 38 days; HR 1.01, 95% CI 0.96 to 1.25) Secondary outcomes No significant difference in death at 6 months (17.2% vs. 16.2%; HR 1.06, 95% CI 0.8 to 1.41) No significant difference in death in the hospital (15.3% vs. 13.9%; RR 1.1, 95% CI 0.83 to 1.44) No significant difference in acquired bacteremia due to Gram-negative organisms (19% vs. 18%; RR 1.05, 95% CI 0.83 to 1.33) Safety outcomes No significant differences in serious adverse events, AKI or use of RRT. Conclusion In patients with deep second or third degree burns within 72 hours after hospital admission, glutamine was not superior to placebo with respect to time to discharge alive from hospital. Reference Daren K Heyland, Lucy Wibbenmeyer, Jonathan A Pollack et al. A Randomized Trial of Enteral Glutamine for Treatment of Burn Injuries. N Engl J Med. 2022 Sep 15;387(11):1001-1010. Open reference URL https://web.pathway.md/studies/recDJ5alYD2qS6uJu 2/2