What is the association between plasma homocysteine concentrations and extracranial carotid-artery stenosis?
The 1995 study by Selhub et al. found an association between higher plasma homocysteine concentrations and extracranial carotid artery stenosis. This was confirmed by subsequent studies, such as the Atherosclerosis Risk in Communities Study (ARIC) and the Perth Carotid Ultrasound Disease Assessment Study (CUDAS), which found that hyperhomocysteinemia was an independent risk determinant of carotid wall thickening.