Guideline sources The following summarized guidelines for the management of actinic keratosis are prepared by our editorial team based on guidelines from the American Academy of Dermatology (AAD 2021). 1 Guidelines 1. Medical management Topical agents: Offer field treatment with 5-fluorouracil or imiquimod for the management of patients with actinic keratosis. B Consider offering topical diclofenac for the management patients with actinic keratosis. C Combination therapy: offer a combination of 5-fluorouracil and cryosurgery for the management of patients with actinic keratosis. B Show 3 more 2. Therapeutic procedures Cryosurgery: Perform cryosurgery for the management of patients with actinic keratosis. E https://web.pathway.md/diseases/recWO47IRjA4MO0mi 1/2 6/23/23, 1:35 AM Actinic keratosis Pathway Consider performing cryosurgery rather than CO laser ablation for the management of patients with actinic keratosis. C Photodynamic therapy: Consider performing photodynamic therapy for the management of patients with actinic keratosis using: ALA-red light C ALA-blue light C aminolevulinic-daylight - it is less painful than but equally effective as ALA-red light. C Show 3 more 3. Preventative measures Ultraviolet protection: advise using UV protection in patients with actinic keratosis. E References 1. Daniel B Eisen, Maryam M Asgari, Daniel D Bennett et al. Guidelines of care for the management of actinic keratosis. J Am Acad Dermatol. 2021 Apr 2;S0190 9622 21 00502 8. Open 2. C A Morton, R M Szeimies, N Basset-Seguin et al. European Dermatology Forum guidelines on topical photodynamic therapy 2019 Part 1 treatment delivery and established indications - actinic keratoses, Bowen's disease and basal cell carcinomas. J Eur Acad Dermatol Venereol. 2019 Dec;33 12 2225 2238. Open https://web.pathway.md/diseases/recWO47IRjA4MO0mi 2/2