6/28/23, 11:22 PM NordICC Pathway Feedback Search Clinical Topics Home Studies NordICC NordICC Disease Disease Colon cancer Rectal cancer Trial question What is the effect of colonoscopy screening on the risks of colorectal cancer? Study design Multi-center Open label RCT Population Characteristics of study participants 50.0% female N = 84585 50.0% male 84585 patients (42186 female, 42399 male) Inclusion criteria: healthy men and women 55 to 64 years of age who had previously not undergone screening Key exclusion criteria: death or diagnosis of colorectal cancer before trial entry Interventions N=28220 colonoscopy screening (one-time colonoscopy screening) N=56365 usual care (no screening or intervention within the trial) Primary outcome Colorectal cancer at 10 years 1.2 % 1.2 https://web.pathway.md/studies/rec1VvshqMhnPObfl 1/2 6/28/23, 11:22 PM NordICC Pathway 0.98 0.9 % 0.6 % 0.3 % Borderline significant decrease 0.0 % Colonoscopy screening Usual care Borderline significant decrease in colorectal cancer at 10 years (0.98% vs. 1.2%; RR 0.82, 95% CI 0.7 to 0.93) Secondary outcomes No significant difference in death from colorectal cancer at 10 years (0.28% vs. 0.31%; RR 0.9, 95% CI 0.64 to 1.16) No significant difference in death from any cause at 10 years (11.03% vs. 11.04%; RR 0.99, 99% CI 0.96 to 1.04) Conclusion In healthy men and women 55 to 64 years of age who had previously not undergone screening, colonoscopy screening was superior to usual care with respect to colorectal cancer at 10 years. Reference Michael Bretthauer, Magnus L berg, Paulina Wieszczy et al. Effect of Colonoscopy Screening on Risks of Colorectal Cancer and Related Death. N Engl J Med. 2022 Oct 27;387(17):1547-1556. Open reference URL https://web.pathway.md/studies/rec1VvshqMhnPObfl 2/2