What is the traditional approach for treating right-sided IE in IDUs?
The traditional approach for treating right-sided IE in IDUs is to use a combined short-course of a -lactam antibiotic such as nafcillin or oxacillin with an aminoglycoside such as gentamicin. This approach has been highly effective in several studies, even for HIV-infected patients and those with large tricuspid valve vegetations. However, there is a growing body of evidence that suggest the addition of adjunctive aminoglycoside therapy may not be necessary and could even cause harm.