6/28/23, 11:10 PM Hydrocortisone, Vitamin C, and Thiamine in Severe Sepsis and Septic Shock Pathway Feedback Search Clinical Topics Home Studies Hydrocortisone, Vitamin C, and Thiamine in Severe Sepsis and Septic Shock Hydrocortisone, Vitamin C, and Thiamine in Severe Sepsis and Septic Shock Disease Sepsis and septic shock Trial question What is the composite effect of vitamin C, hydrocortisone, and thiamine treatment in patients with sepsis and septic shock? Study design Single center Open label Observational study Population Characteristics of study participants 47.0% female N = 94 53.0% male 94 patients (44 female, 50 male) Inclusion criteria: patients with consecutive sepsis or septic shock Key exclusion criteria: < 18 years of age, pregnant, and patients with limitations of care were Interventions N=47 treatment (intravenous vitamin C, hydrocortisone, and thiamine during a 7-month period) N=47 control (treated in ICU without vitamin C or thiamine during the preceding 7 months) Primary outcome Hospital death 40.4 % 40.4 30.3 % https://web.pathway.md/studies/recIVrqB95k0amAJ2 1/2 6/28/23, 11:10 PM Hydrocortisone, Vitamin C, and Thiamine in Severe Sepsis and Septic Shock Pathway 20.2 % Significant decrease 10.1 % NNT = 3 8.5 0.0 % Treatment Control Significant decrease in hospital death (8.5% vs. 40.4%; RR 0.21, 95% CI 0.09 to 0.33) Conclusion In patients with consecutive sepsis or septic shock, treatment was superior to control with respect to hospital death. Reference Marik PE, Khangoora V, Rivera R et al. Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study. Chest. 2017 Jun;151(6):1229-1238. Open reference URL https://web.pathway.md/studies/recIVrqB95k0amAJ2 2/2