What are the biological pathways by which abdominal adiposity increases stroke risk?
The biological pathways by which abdominal adiposity increases stroke risk are not yet understood, but platelet activation, inflammation, endothelial dysfunction, or an overactive endocannabinoid system335 may all serve key roles in the process. In addition, increased very low-density lipoprotein production caused by the high lipolytic activity of abdominal adipose tissue304,312 may increase stroke risk.