6/29/23, 11:56 PM STICH Pathway Feedback Search Clinical Topics Home Studies STICH STICH Disease Disease Coronary artery disease Heart failure Trial question What is the role of coronary artery bypass surgery in patients with LV dysfunction? Study design Multi-center Open label RCT Population Characteristics of study participants 12.0% female N = 1212 88.0% male 1212 patients (148 female, 1064 male) Inclusion criteria: patients with LV dysfunction (LVEF 35%) and coronary artery disease amenable to CABG Key exclusion criteria: plan for percutaneous intervention for CAD, cardiogenic shock within 72 hours of randomization, recent acute MI as a cause of LV dysfunction, noncardiac illness with a life expectancy of < 3 years, or history of > 1 coronary bypass operation Interventions N=610 CABG (CABG plus medical therapy) N=602 medical therapy (medical therapy alone) Primary outcome https://web.pathway.md/studies/rec2FU0WhnSIB4re7 1/2 6/29/23, 11:56 PM STICH Pathway All-cause death 41.0 % 41 36 30.8 % 20.5 % 10.3 % No significant difference 0.0 % Coronary artery bypass graft Medical therapy No significant difference in all-cause death (36% vs. 41%; HR 0.86, 95% CI 0.72 to 1.04) Secondary outcomes Borderline significant decrease in adjudicated death due to cardiovascular cause (28% vs. 33%; HR 0.81, 95% CI 0.66 to 1) Significant decrease in death from any cause or hospitalization for cardiovascular causes (58% vs. 68%; HR 0.74, 95% CI 0.64 to 0.85) Conclusion In patients with LV dysfunction (LVEF 35%) and coronary artery disease amenable to CABG, CABG was not superior to medical therapy with respect to a all-cause death. Reference Velazquez EJ, Lee KL, Deja MA et al. Coronary-artery bypass surgery in patients with left ventricular dysfunction. N Engl J Med. 2011 Apr 28;364(17):1607-16. Open reference URL https://web.pathway.md/studies/rec2FU0WhnSIB4re7 2/2