what are the Recommendations for Anticoagulation for Pregnant Women With
Mechanical Prosthetic Heart Valves
Referenced studies that support the recommendations are
summarized in Online Data Supplement 44.?
For pregnant women with mechanical prostheses who require >5 mg/d of warfarin to achieve a therapeutic INR, dose-adjusted LMWH (with a target anti-Xa level of 0.8 to 1.2 U/mL at 4 to 6 hours after dose) at least 2 times per day during the first trimester, followed by warfarin during the second and third trimesters, is reasonable.