What did the post-hoc analysis of the TOPCAT trial conclude?
The post-hoc analysis of the TOPCAT trial concluded that two distinctly different populations were enrolled in the two regions. The death rate of the cohort from Russia/Georgia was more reflective of the general population than of patients with heart failure. The authors also noted that there was a substantial and clinically important reduction in the primary composite outcome in patients with a phenotype more typical of HFPEF as defined in the UK.