What are the principal disorders of glucose metabolism?
The principal disorders of glucose metabolism are type 1 diabetes, T2D, and prediabetes. Type 1 diabetes is an autoimmune disorder that results in absolute insulin deficiency and accounts for 6% of diabetes in the United States. T2D results from progressive impairment in peripheral insulin sensitivity and pancreatic insulin secretion. It accounts for 91% of diabetes in the United States. Prediabetes has the same pathophysiology as T2D but is associated with lower plasma glucose than in T2D.