What is the recommendation for assessing baseline LDL-C levels before the initiation of statin therapy?
Given relatively modest differences in LDL-C levels between fasting and non-fasting samples, the latter is generally adequate to document baseline lipid levels prior to initiation of statin therapy. However, if more precision is necessary, fasting lipids can be measured. If an individual has ingested an extremely high-fat meal in the preceding 8 hours, it may be prudent to assess lipids on another day after counseling the patient to avoid such meals. In adults with a family history of premature ASCVD or genetic hyperlipidemia, a fasting lipid profile is reasonable for initial evaluation.