What is the effect of diltiazem on renal transplant patients?
Diltiazem has been studied in numerous studies to determine its effects on renal transplant patients. Studies have found that it can help prevent acute tubular necrosis, reduce the risk of acute rejection, and reduce the levels of cyclosporine in the body. Additionally, studies have found that it can reduce the side effects of cyclosporine, such as nephrotoxicity, and improve the overall outcome of cadaver renal transplantation. In addition, diltiazem may help individualize tacrolimus dosages based on cytochrome P450 3A5 polymorphism.  