What is the evidence for adjusting the dose of heparin to maintain a therapeutic range?
The evidence for adjusting the dose of heparin to maintain a therapeutic range is weak and is based on a post hoc subgroup analysis of a descriptive study.66 In contrast, the evidence for maintaining the international normalized ratio (INR) within a therapeutic range in patients who are treated with vitamin K antagonists is strong because it is based on consistent results of randomized trials and case control studies.