7/1/23, 12:31 AM Hepatomegaly Pathway Feedback Search Clinical Topics Home Findings Hepatomegaly Hepatomegaly More common causes Hepatic veno-occlusive disease Kwashiorkor Castleman disease Schistosomiasis Hepatitis B virus infection Tricuspid regurgitation Hereditary hemochromatosis Clonorchiasis Pancreatic cancer Opisthorchiasis Cat-scratch disease Hydatid disease Autosomal dominant polycystic kidney disease Hepatosplenic T-cell lymphoma Amyloidosis Gastric cancer Cutaneous T-cell lymphoma Liver metastasis Mycobacterium tuberculosis infection https://web.pathway.md/findings/recb7CeRUwyCTTy0g 1/6 7/1/23, 12:31 AM Hepatomegaly Pathway Paragonimiasis Less common causes Oesophageal cancer Colon cancer Liver abscess Juvenile chronic arthritis Cystic fibrosis Constrictive pericarditis Hepatic hemangioma Hepatocellular carcinoma Multiple myeloma Primary sclerosing cholangitis Psittacosis Hepatocellular injury Waldenstr m's macroglobulinemia Farber lipogranulomatosis Polycystic liver disease Liver granuloma Extramedullary hemopoiesis Schistosoma japonicum infection Right-sided cardiac failure Hepatic adenoma Amebiasis Schistosoma mansoni Tertiary syphilis Primary biliary cholangitis https://web.pathway.md/findings/recb7CeRUwyCTTy0g 2/6 7/1/23, 12:31 AM Hepatomegaly Pathway Cholangiocarcinoma Wilson's disease Ovarian cancer Toxocariasis Blastic plasmacytoid dendritic cell neoplasm Mantle cell lymphoma Niemann-Pick disease type C Glycogenosis type 1A Congenital syphilis Hairy cell leukemia Hemophagocytic lymphohistiocytosis Bartonellosis Gaucher's disease Hemolytic disease of the newborn Hepatic vein thrombosis Cystic echinococcosis Sandhoff disease Very long-chain acyl-CoA dehydrogenase deficiency Visceral larva migrans Arginosuccinic aciduria Long-chain acyl-CoA dehydrogenase deficiency Lymphomatoid granulomatosis Systemic mastocytosis Visceral leishmaniasis Sphingomyelinase deficiency Myelofibrosis Mucopolysaccharidosis VII https://web.pathway.md/findings/recb7CeRUwyCTTy0g 3/6 7/1/23, 12:31 AM Hepatomegaly Pathway Niemann-Pick disease type B Pyruvate carboxylase deficiency Histiocytosis X Lipoprotein lipase deficiency Small bowel lymphoma Brucellosis Relapsing fever Fumarate hydratase deficiency Uncommon causes Carnitine palmitoyltransferase 1 deficiency Zellweger spectrum Sanfilippo disease Familial hypertriglyceridemia Fibrolamellar hepatocellular carcinoma Malignant osteopetrosis Splenic sequestration crisis Plasma membrane carnitine transporter deficiency Iduronate-2-sulfatase deficiency Juvenile-onset Still's disease Apolipoprotein C-II deficiency Cholesterol ester storage disease Progressive familial intrahepatic cholestasis type 3 Mucopolysaccharidosis type IVB Salla disease Hereditary coproporphyria Focal nodular hyperplasia https://web.pathway.md/findings/recb7CeRUwyCTTy0g 4/6 7/1/23, 12:31 AM Hepatomegaly Pathway Congenital generalized lipodystrophy type 1 Chanarin-Dorfman disease Glycogenosis type 3 Fucosidosis Mucopolysaccharidosis VI Type 1 GM1 gangliosidosis Chediak-Higashi disease Glycogenosis type 1b Glycogenosis type 2 Glycogenosis type 4 Riedel lobe of liver Glutaric acidemia type 2 Prolidase deficiency Gamma heavy chain disease Galactose-1-phosphate uridyltransferase deficiency Glycogenosis type 6 Arginosuccinate synthetase deficiency Mucolipidosis II alpha/beta Phosphoglycerate kinase deficiency Carnitine-acylcarnitine translocase deficiency Fructose-1-phosphate aldolase deficiency Long chain hydroxyacyl-CoA dehydrogenase deficiency Sialidosis type 2 Congenital generalized lipodystrophy type 2 Hepatic venoocclusive disease with immunodeficiency Angioimmunoblastic lymphadenopathy with dysproteinaemia Fructose-1/6-diphosphatase deficiency https://web.pathway.md/findings/recb7CeRUwyCTTy0g 5/6 7/1/23, 12:31 AM Hepatomegaly Pathway Familial histiocytic reticulosis Acanthocheilonemiasis Mu chain disease Galactose epimerase deficiency Dicrocoelium dendriticum fluke Geleophysic dysplasia Glycine N-methyltransferase deficiency Congenital disorder of glycosylation type 1h Type 3 GM1 gangliosidosis Adenosine deaminase 2 deficiency Faisalabad histiocytosis Hypermanganesemia with dystonia / polycythemia / and cirrhosis Familial alphalipoprotein deficiency Alpha-mannosidase deficiency French type sialuria https://web.pathway.md/findings/recb7CeRUwyCTTy0g 6/6