What is the treatment recommendation for patients with moderate CKD (Stage III, CrCl 30-59 mL/min) and a CHA2DS2-VASc score of 2?
For patients with moderate CKD (Stage III, CrCl 30-59 mL/min) and a CHA2DS2-VASc score of 2, we suggest oral anticoagulation with label-adjusted NOACs or dose-adjusted vitamin K antagonists (Weak recommendation, very low quality evidence). With VKA, good quality anticoagulation control (TTR > 65-70%) is recommended.