What is the cost effectiveness of NP monitoring for patients with heart failure?
The study found NP monitoring to be cost effective for all sub-groups, and even dominated specialist-led clinically-guided therapy in all heart failure patients over 75. The study also reported incremental net monetary benefit results with 95% confidence intervals. These results suggest there is uncertainty in the cost effectiveness of NP monitoring for HF-PEF patients less than 75 years of age and both all heart failure and HF-REF patients over 75 years of age, with 95% confidence intervals ranging from negative to positive. The study also carried out a sensitivity analysis using IPD meta-analysis data from a more recent health technology assessment, in which this economic evaluation was developed. However, this was only assessed for HF-REF patients less than 75 years old. The results of this suggest that NP monitoring is cost effective compared to clinically-guided therapy, however this is more uncertain than the base-case results as the 95% confidence intervals of the incremental net monetary benefit now range from negative to positive.