What is the significance of a positive family history for coronary heart disease?
A study by Cohen et al. (2014) found that a positive family history for coronary heart disease is associated with an increased risk of coronary heart disease, even in patients with a zero coronary artery calcium score (from the Multi-Ethnic Study of Atherosclerosis). This suggests that genetic factors may contribute to coronary heart disease risk, even in those with low levels of coronary calcification.