What studies provided the rationale for double -lactam therapeutic trials in humans with E faecalis IE?
In vitro and in vivo studies provided the rationale for double -lactam therapeutic trials in humans with E faecalis IE. These studies included a large, multicenter study by Spanish and Italian investigators which compared ampicillin-ceftriaxone with ampicillin-gentamicin therapy of E faecalis IE, and a smaller study by the same group which compared ceftriaxone-ampicillin therapy of aminoglycoside-susceptible with high-level aminoglycoside-resistant E faecalis IE.