6/29/23, 1:10 AM RESCUE BT Pathway Feedback Search Clinical Topics Home Studies RESCUE BT RESCUE BT Disease Acute ischemic stroke Trial question What is the role of intravenous tirofiban in patients with large vessel occlusion acute ischemic stroke undergoing endovascular thrombectomy? Study design Multi-center Double blinded RCT Population Characteristics of study participants 41.0% female N = 948 59.0% male 948 patients (391 female, 557 male) Inclusion criteria: patients with stroke and proximal intracranial large vessel occlusion presenting < 24 hours of time last known well Key exclusion criteria: intracranial hemorrhage; dual antiplatelet therapy < 1 week of the index stroke; receipt of intravenous thrombolysis after stroke onset; renal insufficiency Interventions N=463 tirofiban (bolus of 10 g/kg, followed by continuous infusion of 0.15 g/kg/min before endovascular thrombectomy) N=485 placebo (saline placebo before endovascular thrombectomy) https://web.pathway.md/studies/recs7Wc0idF2hf9yw 1/2 6/29/23, 1:10 AM RESCUE BT Pathway Primary outcome Disability level, modified rankin scale score, at day 90 3.0 3 3 2.3 1.5 0.8 No significant difference 0.0 Tirofiban Placebo No significant difference in disability level, mRS score, at day 90 (3 vs. 3; OR 1.11, 95% CI 0.86 to 1.36) Secondary outcomes No significant difference in mRS score of 0-2 at day 90 (49.2% vs. 45.2%; OR 1.18, 95% CI 0.92 to 1.59) No significant difference in European Quality 5-Dimension 5-Level self-report questionnaire score at day 90 (0.71 vs. 0.66; AD 0.05, 95% CI -0.04 to 0.14) Safety outcomes No significant differences in symptomatic intracranial hemorrhage < 48 hours, mortality at day 90. Significant difference in any radiologic intracranial hemorrhage (34.9% vs. 28.0%). Conclusion In patients with stroke and proximal intracranial large vessel occlusion presenting < 24 hours of time last known well, tirofiban was not superior to placebo with respect to disability level, mRS score, at day 90. Reference RESCUE BT Trial Investigators, Zhongming Qiu, Fengli Li et al. Effect of Intravenous Tirofiban vs Placebo Before Endovascular Thrombectomy on Functional Outcomes in Large Vessel Occlusion Stroke: The RESCUE BT Randomized Clinical Trial. JAMA. 2022 Aug 9;328(6):543-553. Open reference URL https://web.pathway.md/studies/recs7Wc0idF2hf9yw 2/2