6/28/23, 10:10 PM EXTUB-OBESE Pathway Feedback Search Clinical Topics Home Studies EXTUB OBESE EXTUB OBESE Disease Obesity Trial question What is the effect of noninvasive ventilation following extubation of critically ill patients with obesity? Study design Multi-center Open label RCT Population 981 patients Inclusion criteria: critically ill patients with obesity undergoing extubation Key exclusion criteria: formal indication of noninvasive ventilation; pregnancy; tracheostomy; anatomical factors precluding the use of noninvasive ventilation Interventions N=490 noninvasive ventilation (receipt of noninvasive ventilation) N=491 oxygen therapy (receipt of standard oxygen therapy) Primary outcome Rate of treatment failure within 3 days 26.5 % 26.5 19.9 % 13.5 13.3 % Significant decrease 6.6 % NNT = 8 0.0 % Noninvasive ventilation Oxygen therapy https://web.pathway.md/studies/recD0jACVMntFJTiS 1/2 6/28/23, 10:10 PM EXTUB-OBESE Pathway Significant decrease in the rate of treatment failure within 3 days (13.5% vs. 26.5%; RR 0.43, 95% CI 0.31 to 0.6) Secondary outcomes No significant difference in the rate of acute respiratory failure within 7 days after extubation (11% vs. 14%; RR 0.75, 95% CI 0.51 to 1.09) No significant difference in the rate of reintubation within 3 days after extubation (10% vs. 12%; RR 0.8, 95% CI 0.53 to 1.19) No significant difference in death at day 28 (5% vs. 6%; RR 0.87, 95% CI 0.51 to 1.49) Conclusion In critically ill patients with obesity undergoing extubation, noninvasive ventilation was superior to oxygen therapy with respect to the rate of treatment failure within 3 days. Reference Audrey De Jong, Anne Bignon, Fran ois Stephan et al. Effect of non-invasive ventilation after extubation in critically ill patients with obesity in France: a multicentre, unblinded, pragmatic randomised clinical trial. Lancet Respir Med. 2023 Jun;11(6):530-539. Open reference URL https://web.pathway.md/studies/recD0jACVMntFJTiS 2/2