6/28/23, 12:03 AM CARP Pathway Feedback Search Clinical Topics Home Studies CARP CARP Disease Coronary artery disease Trial question What is the role of coronary artery revascularization in patients at increased risk for perioperative cardiac complications and clinically significant coronary artery disease? Study design Multi-center Open label RCT Population 510 patients Inclusion criteria: patients at increased risk for perioperative cardiac complications and clinically significant coronary artery disease Key exclusion criteria: need for urgent or emergency surgery, a severe coexisting illness, or prior revascularization without evidence of recurrent ischemia Interventions N=258 coronary artery revascularization (either PCI or bypass surgery) N=252 no revascularization (no PCI or bypass surgery) Primary outcome Rate of death at a mean follow-up of 2.7 years 23.0 % 23 22 17.3 % 11.5 % 5.8 % No significant difference 0.0 % Coronary artery revascularization No revascularization https://web.pathway.md/studies/recKrNdn8xep0ciT4 1/2 6/28/23, 12:03 AM CARP Pathway No significant difference in the rate of death at a mean follow-up of 2.7 years (22% vs. 23%; RR 0.98, 95% CI 0.7 to 1.37) Secondary outcomes No significant difference in the rate of postoperative myocardial infarction, within 30 days of vascular operation (12% vs. 14%; RR 0.86, 95% CI -1 to 2.72) Conclusion In patients at increased risk for perioperative cardiac complications and clinically significant coronary artery disease, coronary artery revascularization was not superior to no revascularization with respect to the rate of death at a mean follow-up of 2.7 years. Reference McFalls EO, Ward HB, Moritz TE et al. Coronary-artery revascularization before elective major vascular surgery. N Engl J Med. 2004 Dec 30;351(27):2795-804. Open reference URL https://web.pathway.md/studies/recKrNdn8xep0ciT4 2/2