What is the risk associated with severe hypercholesterolemia?
Patients with primary severe hypercholesterolemia (LDL-C levels 190 mg/dL [4.9 mmol/L]) have a high-risk of ASCVDS, premature and recurrent coronary events, and a reduced incidence of MI and cardiovascular death when receiving pravastatin 40 mg. In addition, retrospective cohort studies have demonstrated that statin therapy reduces risk of incident CHD and all-cause death in patients with phenotypic or genetically confirmed FH.