What is the most prevalent pathogen among these uncommon causes of culture-negative IE?
According to published data, the most prevalent pathogen among these uncommon causes of culture-negative IE in this group has varied globally. Serological results were positive in 47.7% of cases, primarily for Coxiella and Bartonella species infection. PCR identified a pathogen in two thirds of the valves studied, and no cause was defined in 35% of cases. Treatment of the wide variety of microorganisms that cause culture-negative IE without prior antibiotic exposure has been described anecdotally. 