What did the committee decide to do in order to limit their ability to establish the most appropriate test thresholds?
The committee decided to contact study authors seeking additional data at the particular thresholds. The committee decided to limit this request to data on NT-proBNP rather than BNP for multiple reasons including the clinical review demonstrating that NT-proBNP has a greater sensitivity over a range of thresholds compared to BNP, the majority of the high quality NT-proBNP studies being more recent and more likely to be applicable to current practice, and the difficulty of comparing thresholds between BNP and NT-proBNP.