6/28/23, 12:28 AM Cranberry for prevention of pyuria and bacteriuria Pathway Feedback Search Clinical Topics Home Studies Cranberry for prevention of pyuria and bacteriuria Cranberry for prevention of pyuria and bacteriuria Disease Disease Acute cystitis Asymptomatic bacteriuria Trial question What is the effect of cranberry capsules on bacteriuria plus pyuria in older women living in nursing homes? Study design Multi-center Double blinded RCT Population 185 female patients Inclusion criteria: women aged 65 years or older, with or without bacteriuria plus pyuria at baseline, residing in nursing homes Key exclusion criteria: short term rehabilitation, pending discharge, terminal life expectancy < 1 month; on chronic suppressive antibiotic or anti-infective (i.e., mandelamine) therapy for recurrent UTI; on dialysis for end stage renal disease; unable to produce a baseline clean catch urine specimen; on warfarin therapy; history of nephrolithiasis; presence of an indwelling bladder catheter; allergy to cranberry products; or treatment with cranberry products Interventions N=92 cranberry capsules (2 oral capsules once daily, containing 72 mg total of the active ingredient proanthocyanidin, equivalent to 20 ounces of cranberry juice) N=93 placebo (two matching capsules once daily) Primary outcome Bacteriuria plus pyuria 29.1 % 29.1 29 21.8 % 14.6 % 7.3 % https://web.pathway.md/studies/recuExkcj6cwzFUgH 1/2 6/28/23, 12:28 AM Cranberry for prevention of pyuria and bacteriuria Pathway 0.0 % No significant difference Cranberry capsules Placebo No significant difference in bacteriuria plus pyuria (29.1% vs. 29%; OR 1.01, 95% CI 0.61 to 1.66) Conclusion In women aged 65 years or older, with or without bacteriuria plus pyuria at baseline, residing in nursing homes, cranberry capsules were not superior to placebo with respect to bacteriuria plus pyuria. Reference Juthani-Mehta M, Van Ness PH, Bianco L et al. Effect of Cranberry Capsules on Bacteriuria Plus Pyuria Among Older Women in Nursing Homes: A Randomized Clinical Trial. JAMA. 2016 Nov 8;316(18):1879-1887. Open reference URL https://web.pathway.md/studies/recuExkcj6cwzFUgH 2/2