what are the Recommendations for GDMT Dosing: Sequencing and Uptitration
Referenced studies that support the recommendations are
summarized in the Online Data Supplements.?
In patients with HFrEF, titration of guideline- directed medication dosing to achieve target doses showed to be efficacious in RCTs is rec- ommended, to reduce cardiovascular mortality and HF hospitalizations, unless not well toler- ated.