What evidence exists that combining ACE-Is and ARBs may be more effective than using each agent alone?
A number of moderate-sized studies, mostly in patients with diabetes, have demonstrated that proteinuria levels may be further lowered by combining ACE-Is and ARBs than by using each agent alone.423 Aldosterone antagonists may substantially lower proteinuria when used on top of ACE-Is Similarly when the DRI, aliskiren, was added to proteinuria was reduced.