What are some risk factors for major bleeding in patients with ACS?
Risk factors for major bleeding in patients with ACS have been identified from several clinical trials535,544 546 (Table 13). These include patient comorbidities,536,537 discontinuation of antiplatelet or anticoagulant therapy in response to bleeding,536,538 and blood transfusion.539,540 Additional considerations include types of antiplatelet or anticoagulant agent at time of PCI,248,541,542 number of antithrombotic agents used,533 duration of therapy, crossover from low-molecular-weight heparin to UFH, HF or shock, diabetes mellitus, peripheral artery disease, and prior warfarin use. 