6/28/23, 11:02 PM Lidocaine in Hepatectomy Pathway Feedback Search Clinical Topics Home Studies Lidocaine in Hepatectomy Lidocaine in Hepatectomy Disease Disease Disease Cholangiocarcinoma Hepatic adenoma Hepatoce Trial question What is the effect of prolonged intravenous lidocaine infusion following hepatectomy? Study design Single center Double blinded RCT Population 260 patients Inclusion criteria: patients undergoing elective hepatectomy Key exclusion criteria: body weight < 40 kg or > 100 kg; metastases occurring in other distant organs; severe hepatic insufficiency; renal impairment; cardiac rhythm disorder or systolic HF Interventions N=130 lidocaine (infusion of intravenous lidocaine hydrochloride 1.5 mg/kg during anesthesia) N=130 placebo (infusion of 0.9% normal saline during anesthesia) Primary outcome Moderate-to-severe movement-evoked pain at 24 hour postoperatively 67.7 % 67.7 50.8 % 47.7 33.9 % Significant decrease 16.9 % NNT = 5 0.0 % Lidocaine Placebo https://web.pathway.md/studies/recRlHWeI7L3xdgvd 1/2 6/28/23, 11:02 PM Lidocaine in Hepatectomy Pathway Significant decrease in moderate-to-severe movement-evoked pain at 24 hour postoperatively (47.7% vs. 67.7%; RR 0.71, 95% CI 0.29 to 1.13) Secondary outcomes Significant decrease in moderate-to-severe movement-evoked pain at 48 hour postoperatively (38.5% vs. 58.5%; RR 0.66, 95% CI 0.27 to 1.05) Significant decrease in reduction in movement-evoked pain scores (3.7 vs. 4.2; AD -0.5, 95% CI -0.9 to -0.1) Significant decrease in morphine equivalent connsumption (47.2 mg vs. 52.6 mg; AD -5.4 mg, 95% CI -9.8 to -1) Conclusion In patients undergoing elective hepatectomy, lidocaine was superior to placebo with respect to a moderate-to-severe movement-evoked pain at 24 hour postoperatively. Reference Yan Xu, Mao Ye, Fei Liu et al. Efficacy of prolonged intravenous lidocaine infusion for postoperative movement-evoked pain following hepatectomy: a double-blinded, randomised, placebo-controlled trial. Br J Anaesth. 2023 May 16;S0007-0912(23)00169-1. Open reference URL https://web.pathway.md/studies/recRlHWeI7L3xdgvd 2/2