What are the contrasting effects of calcium channel blockade versus converting enzyme inhibition on proteinuria in African Americans with non-insulin-dependent diabetes mellitus and nephropathy?
According to a study published in the Journal of the American Society of Nephrology in 1997, calcium channel blockade had a greater effect than converting enzyme inhibition on proteinuria in African Americans with non-insulin-dependent diabetes mellitus and nephropathy. The study found that calcium channel blockers such as nifedipine had a greater effect on decreasing proteinuria compared to angiotensin-converting enzyme (ACE) inhibitors such as lisinopril. The study also found that calcium channel blockers had beneficial effects on tubular transport functions, while ACE inhibitors did not have a significant effect on this metric.  