6/29/23, 1:45 AM PReVENT Pathway Feedback Search Clinical Topics Home Studies PReVENT PReVENT Trial question What is the effect of low tidal volume strategy in ICU patients without ARDS? Study design Multi-center Open label RCT Population Characteristics of study participants 35.0% female N = 961 65.0% male 961 patients (340 female, 621 male) Inclusion criteria: ICU patients without ARDS expected to not be extubated within 24 hours after start of ventilation Key exclusion criteria: presence of ARDS; ventilation lasting > 12 hours before admission to the ICU; uncontrollable ICP; pulmonary disease and new pulmonary thromboembolism Interventions N=477 a low tidal volume ventilation strategy (at a tidal volume of 4-6 mL/kg predicted body weight) N=484 an intermediate tidal volume ventilation strategy (at a tidal volume of 8-10 mL/kg predicted body weight) Primary outcome Ventilator-free days 21.0 days 21 21 15.8 days 10.5 days https://web.pathway.md/studies/reclObYgO0Lk2bxOs 1/2 6/29/23, 1:45 AM PReVENT Pathway 5.3 days No significant difference 0.0 days A low tidal volume ventilation strategy An intermediate tidal volume ventilation strategy No significant difference in ventilator-free days (21 days vs. 21 days; AD -0.27 days, 95% CI -1.74 to 1.19) Secondary outcomes No significant difference in length of ICU stay (6 days vs. 6 days; AD 0.39 days, 95% CI -1.09 to 1.89) No significant difference in length of hospital stay (14 days vs. 15 days; AD -0.6 days, 95% CI -3.52 to 2.31) No significant difference in the rate of death by day 28 (34.9% vs. 32.1%; HR 1.12, 95% CI 0.9 to 1.4) Safety outcomes No significant differences in ARDS, pneumonia, severe atelectasis, pneumothorax, delirium, extrapulmonary infection and sepsis. Conclusion In ICU patients without ARDS expected to not be extubated within 24 hours after start of ventilation, a low tidal volume ventilation strategy was not superior to an intermediate tidal volume ventilation strategy with respect to a ventilator-free days. Reference Writing Group for the PReVENT Investigators, Fabienne D Simonis, Ary Serpa Neto et al. Effect of a Low vs Intermediate Tidal Volume Strategy on Ventilator-Free Days in Intensive Care Unit Patients Without ARDS: A Randomized Clinical Trial. JAMA. 2018 Nov 13;320(18):1872-1880. Open reference URL https://web.pathway.md/studies/reclObYgO0Lk2bxOs 2/2