What are the RCTs that have demonstrated benefit in treating patients with prior stroke or TIA to achieve a goal BP of <130/80 mmHg?
Data from 4 RCTs and recent meta-analyses support a benefit of treating patients with prior stroke or TIA to achieve a goal BP of <130/80 mmHg. The RESPECT (Randomized Evaluation of Recurrent Stroke Comparing PFO Closure to Established Current Standard of Care Treatment),190 PAST-BP (Prevention After Stroke Blood Pressure),191 SPS3 (Secondary Prevention of Small Subcortical and PODCAST (Prevention of Decline in Cognition after Stroke Trial)193 RCTs all compared intensive control of BP (SBP targets ranging from <120 <130 mmHg) with standard BP control (SBP targets ranging from <140 <150 mmHg) in patients with prior cerebrovascular disease.