What is the clinical and cost effectiveness of iron supplementation in people with chronic heart failure and iron deficiency?
A search was conducted for randomised trials investigating the effectiveness of intravenous (IV) or oral iron supplementation, compared with each other or placebo, for patients with heart failure (HF) who also have iron deficiency (ID). The trials included FERRIC-HF, FAIR-HF, and IRONOUT HF200; these are summarised in Table 51 below. Outcomes evaluated included mortality, quality of life, unplanned hospitalisation, improvement in exercise tolerance, change in haemoglobin in anaemic patients, withdrawal due to adverse events/tolerability, and adverse events (hypertension, anaphylaxis/hypersensitivity, stroke, gastrointestinal).