What are the treatment regimens for NVE caused by relatively penicillin-resistant strains?
It is reasonable to administer penicillin for 4 weeks with single daily-dose gentamicin for the first 2 weeks of therapy (Class IIa; Level of Evidence B). If the isolate is ceftriaxone susceptible, then ceftriaxone alone may be considered (Class IIb; Level of Evidence C). Vancomycin alone may be a reasonable alternative in patients who are intolerant of -lactam therapy (Class IIa; Level of Evidence C). Consultation with an infectious diseases specialist is encouraged in both of these scenarios.