6/28/23, 12:02 AM CAPITAL CHILL Pathway Feedback Search Clinical Topics Home Studies CAPITAL CHILL CAPITAL CHILL Disease Cardiac arrest Trial question Is moderate therapeutic hypothermia superior to mild therapeutic hypothermia among comatose survivors of out-of-hospital cardiac arrest? Study design Single center Double blinded RCT Population Characteristics of study participants 19.0% female N = 367 81.0% male 367 patients (69 female, 298 male) Inclusion criteria: patients with out-of-hospital cardiac arrest surviving to hospital admission and referred for post-cardiac arrest care Key exclusion criteria: known inability to perform activities of daily living, cardiac arrest secondary to intracranial bleed, severe coagulopathy with clinical evidence of major bleeding, coma not attributable to the cardiac arrest Interventions N=193 moderate hypothermia (a target body temperature of 31 degree Celsius for a period of 24 hours) N=196 mild hypothermia (a target body temperature of 34 degree Celsius for a period of 24 hours) Primary outcome https://web.pathway.md/studies/reckiaCgHfor96wWu 1/2 6/28/23, 12:02 AM CAPITAL CHILL Pathway Death or poor neurologic outcome at day 180 48.4 % 48.4 45.4 36.3 % 24.2 % 12.1 % No significant difference 0.0 % Moderate hypothermia Mild hypothermia No significant difference in death or poor neurologic outcome at day 180 (48.4% vs. 45.4%; RR 1.07, 95% CI 0.86 to 1.33) Secondary outcomes No significant difference in death at day 180 (43.5% vs. 41%; RR 1.06, 95% CI 0.83 to 1.35) No significant difference in stroke at day 180 (4.4% vs. 1.6%; RR 2.65, 95% CI 0.71 to 9.84) No significant difference in length of stay in the ICU (10 days vs. 7 days; AD 1.4 days, 95% CI -1.2 to 4.1) Safety outcomes No significant differences in deep vein thrombosis, IVC thrombus. Conclusion In patients with out-of-hospital cardiac arrest surviving to hospital admission and referred for post-cardiac arrest care, moderate hypothermia was not superior to mild hypothermia with respect to death or poor neurologic outcome at day 180. Reference Michel Le May, Christina Osborne, Juan Russo et al. Effect of Moderate vs Mild Therapeutic Hypothermia on Mortality and Neurologic Outcomes in Comatose Survivors of Out-of-Hospital Cardiac Arrest: The CAPITAL CHILL Randomized Clinical Trial. JAMA. 2021 Oct 19;326(15):1494-1503. Open reference URL https://web.pathway.md/studies/reckiaCgHfor96wWu 2/2