What are the indications for coronary artery calcium measurement in intermediate-risk adults?
In adults at intermediate risk, coronary artery calcium measurement can be effective for meaningfully reclassifying risk in a large proportion of individuals. Those with coronary artery calcium scores of 100 AU or 75th percentile have ASCVD event rates for which initiation of statin therapy is reasonable. Those with coronary artery calcium scores of 1 to 99 AU have modest 10-year ASCVD event rates, and those with coronary artery calcium scores of zero appear to have 10-year event rates in a lower range for which statin therapy may be of limited value. It is reasonable to repeat the risk discussion for those with coronary artery calcium scores of 1 to 99, and repeat coronary artery calcium measurement in 5 years may have some value for these individuals. Selected examples of candidates who might benefit from knowing that their coronary artery calcium scores are zero are listed in Table 6. 