What is the recommendation regarding hemodilution for treatment of patients with AIS?
Hemodilution by volume expansion is not recommended for treatment of patients with AIS. This recommendation and Level of Evidence (LOE) remains unchanged from the 2013 AIS Guidelines. This is based on a Cochrane review of 4174 participants from multiple randomized controlled trials (RCTs) which confirmed the previous guideline recommendation that hemodilution therapy, including varying methods of volume expansion with or without venesection, demonstrates no significant benefit in patients with AIS.