6/29/23, 11:45 PM SPRINT (secondary analysis) Pathway Feedback Search Clinical Topics Home Studies SPRINT (secondary analysis) SPRINT (secondary analysis) Disease Hypertension Trial question What is the long-term effect of intensive BP control in patients with hypertension? Study design Multi-center Open label RCT Population Characteristics of study participants 36.0% female N = 9361 64.0% male 9361 patients (3332 female, 6029 male) Inclusion criteria: patients 50 years of age with hypertension and increased cardiovascular risk Key exclusion criteria: 1 minute standing systolic BP < 110 mgHg; diabetes mellitus; history of stroke; polycystic kidney disease; cardiovascular event/procedure Interventions N=4678 intensive BP control (systolic BP goal < 120 mmHg) N=4683 standard BP control (systolic BP goal < 140 mmHg) Primary outcome Rate of death from cardiovascular causes at a follow-up of 8.8 years 4.3 % 4.28 4.25 https://web.pathway.md/studies/recm7uMmwl1NrbkZk 1/2 6/29/23, 11:45 PM 3 % SPRINT (secondary analysis) Pathway 8 4.25 3.2 % 2.1 % 1.1 % No significant difference 0.0 % Intensive blood pressure control Standard blood pressure control No significant difference in the rate of death from cardiovascular causes at a follow-up of 8.8 years (4.28% vs. 4.25%; HR 1.02, 95% CI 0.84 to 1.24) Secondary outcomes No significant difference in the rate of death from all causes at a follow-up of 8.8 years (13.5% vs. 12.6%; HR 1.08, 95% CI 0.94 to 1.23) Borderline significant decrease in the rate of death from cardiovascular causes at a follow-up of 3.3 years (1.36% vs. 1.96%; HR 0.66, 95% CI 0.49 to 0.89) No significant difference in the rate of death from all causes at a follow-up of 3.3 years (5.2% vs. 6.2%; HR 0.83, 95% CI 0.68 to 1.01) Conclusion In patients 50 years of age with hypertension and increased cardiovascular risk, intensive BP control was not superior to standard BP control with respect to the rate of death from cardiovascular causes at a follow-up of 8.8 years. Reference Byron C Jaeger, Adam P Bress, Joshua D Bundy et al. Longer-Term All-Cause and Cardiovascular Mortality With Intensive Blood Pressure Control: A Secondary Analysis of a Randomized Clinical Trial. JAMA Cardiol. 2022 Nov 1;7(11):1138-1146. Open reference URL https://web.pathway.md/studies/recm7uMmwl1NrbkZk 2/2