What are the effects of dietary sodium on blood pressure in insulin-dependent diabetes mellitus (IDDM) patients with nephropathy?
Muhlhauser et al. (1996) studied the effects of dietary sodium on blood pressure in IDDM patients with nephropathy and found that a low-sodium diet was associated with lower blood pressure levels. They also found that an increase in dietary sodium led to an increase in blood pressure. Additionally, Trevisan et al. (1998) found that insulin-resistant IDDM patients with microalbuminuria had an enhanced responsiveness of blood pressure to sodium intake and to angiotensin II. Imanishi et al. (2001) observed that sodium sensitivity related to albuminuria appeared before hypertension became apparent in type 2 diabetic patients. Petrie et al. (1998) reported that dietary sodium restriction impaired insulin sensitivity in noninsulin-dependent diabetes mellitus.