anti-D 390, 441 antibacterial 550 antibiotics 569 anticoagulation 401 antifungal 550 antivi ral 550 neonatal 360 and purine analogs 558 special situations 550 \200\2231 378 \200\22380 function analysis-100, 371 function tests 370 \200\2231 irradiated 650 low 69 numerical abn ormalities of protein C 396, 398 C deficiency 397 -calorie malnutrition 495 S deficiency 397 see thrombocytopenia; thrombocytosis 704 prothrombin gene mutation 397 22-OHC2e_index.qxd 10.12.2003 04.36 PM Page 705 protocols and procedures 544 \200\223628 neutropenia, IV antibiotics, use of ABVD 596 adriamycin (doxorubicin), BCNU 552 \200\2233 neutropenia, prophylaxis for 550 \200\2231 neutropenic sepsis treatment when (carmustine), cyclophosphamide, melphalan (ABCM) 620 source known/suspected 556 \200\2237 anticoagulation, oral 590 anticoagulation therapy - heparin neutropenic sepsis treatment when source unknown 554 \200\2235 588 \200\2239 plasma exchange (plasmapheresis) BEAM (myeloablative conditioning regimen) 610, 612 \200\22313 584 \200\2235 platelet reactions and refractoriness bone marrow examination 570 \200\2231 bone marrow failure, chronic 562 \200\2233 C-Thal-Dex 628 catheters, tunneled central venous 548 \200\2239 platelet storage and administration 546 \200\2237 platelet transfusion support 547 prophylaxis and purine analogs 568 \200\2239 chemotherapy administration 558 572 \200\2233 R-CHOP splenectomy 582 \200\2233 tumor lysis syndrome, acute 560 \200\2231 VAPEC-B 594 \200 \2235 venepuncture 564 venesection 566 vincristine, adriamycin (doxorubicin), dexamethasone (VAD) 624 chemotherapy antiemetics 574 \200\2235 chemotherapy, intrathecal 576 chlorambucil, vinblast ine, procarbazine, prednisolone (ChIVPP) 598 chlormethine (mustine), vincristine, procarbazine, prednisolone (MOPP) 600 chlormethine (mustine), vincristine, Z-DEX 626 procarbazine, prednisolone/adriamycin (doxorubicin), bleomycin, vinblastine, dacarbazine (M OPP/ABVD) 602 psychological support 540 psychosocial problems 73 purine analogs 177, 179, 202, 287, 558 purpura CVP 614 cyclophosphamide, vincristine, idiopathic thrombocytopenic 388, 392 adriamycin (doxorubicin), methylprednisolone (C-VAMP) 622 cyclophosphamide, vincristine, post-transfusion 392, 506 thrombocytopenic childhood immune (idiopathic) 466 \200\2237 thrombotic thrombocytopenic doxorubicin, prednisolone (CHOP) 604 dexamethasone, cisplatin, 530 \200\2231 pyknocytosis, infantile 439 pyridoxine deficiency see vitamin B6 pyruvate kin ase deficiency 104 \200\2235 cytarabine (DHAP) 606 \200\2237 ESHAP 608 \200\2239 extravasation 578 \200\2239, 580 fludarabine and cyclophosphamide 616 quality of life 536 fludarabine, mitoxantrone (mitozantrone), dexamethasone (FMD) 618 leucapheresis 586 leukemia, acute, investigation of 544 needlestick injuries 592 \200\2233 705 radioactive phosphorus 243 \200\2234 22-OHC2e_index.qxd 10.12.2003 04.36 PM Page 706 radiology 302, 353, 471, 544 radiotherapy 201, 258, 279, 594 methaemoglobinaemia 110 microangiopathic haemolytic anemia (MAHA) 112 adjuvant 213 ranges, normal 688 \200\22390 rasburicase 161, 560 \200\22361 red cell 316, 422 nucleotide metabolism - pyrimidine 5 \200\231 nucleotidase deficiency 106 \200\2237 pyruvate kinase deficiency 104 \200\2235 sickle cell trait (HbAS) 78 sickling disorders 72 \200\2234 spherocytosis, heredi tary 98 \200\2239 starvation 66 thalassaemia 86 aplasia, acquired 454 \200\2235 aplasia, congenital 452 \200\2233 defects, acquired 438 \200\2239 defects, congenital 436 \200\2237 disorders 44 \200\223131 acanthocytosis 114 anemia 86 \200\2237 88 \200\22390 HbS 80 HbS 80 heterozygous 92 heterozygous 92 homozygous 92 \210 92 aplastic 122 \200\2233 autoimmune haemolytic 116 \200\22317 drug-induced haemolytic 108 in endocrine disease 48 in gastrointestinal disease 52 in joint disease 50 \200\2231 leucoeryt hroblastic 120 in liver disease 54 and peripheral blood movie 44 in renal disease 46 aplasi a, pure red cell 126 cold haemagglutinin disease (CHAD) 118 elliptocytosis, hereditary 100 folate deficiency 62 \200\2233 glucose-6 \200\223phosphate transfusion haemosiderosis 130 \200\2231 vitamin A deficiency 66 vitamin B6 (pyridoxine) deficiency 66 vitamin B12 deficiency 60 \200\2231 vitamin C deficiency 66 vitamin E deficie ncy 66 enzyme disorder 69 mass, increased 246 production failure 562 supportive transfusions 317 t ransfusion 230, 424 \200\2236, 524, 648 \200\2239 relapse post-allogeneic SCT, treatment dehydrogenase deficiency 102 \200\2233 glycolytic pathway 106 hemoglobin disorders, Hb patt erns of 94 hemoglobin, fetal, hereditary persistence of 93 hemoglobin production, genetic of 338 renal abnormality 69 disease and anemia 46 failure 379 impairment, correction of 277 control of 70 \200\2231 hemoglobin, unstable 84 haemoglobinuria, paroxysmal nocturnal 124 \200\2235 haemolysis, non -immume 96 \200\2237 haemolytic syndromes 68 \200\2239 HbC 82 HbD 82 HbE 82 HbLepore 92 HbS C 80 HbSD 80 HbSO 80 iron deficiency anemia 56 \200\2238 iron overload 128 \200\2239 megalo blastic anemia 64 respiratory investigations 302 reticular dysgenesis 408 reticulocytes 634 \200\2235 rhesus (D) mismatch 318 rheumatoid arthritis, juvenile 494 ristocetin-induced platelet agglutination 349 rituximab 177, 202 respiratory syncytial virus 557 706 St Jude staging system 479 22-OHC2e_index.qxd 10.12.2003 04.37 PM Page 707 salvage therapy 205, 213 \200\22314 Schumm \200\231s test 633 scurvy 495 Seckel \200\231s s yndrome 460 sedation 569 sepsis 69 surgery 244, 253, 350 and bleeding, prolonged 38 \200\2239 system lupus erythematosus 494 systemic disease in children, hematological effects of 494 \200\2236 systemic fibrinolyis 524 severe 17 septic shock 500 sequestration crises 73 serum ferritin level 11 paraprotein 32 sex hormones 48 S zary syndrome 190 sharps injury 592 sho rt chain fatty acids 76 Shwachman-Diamond syndrome T cells 408, 410, 479 T lineage 158 tacrolimus 322 tapeworms 495 thalassaemia 86 88 \200 \22390 HbS 80 HbS 80 heterozygous 92 heterozygous 92 homozygous 92 92 459 \200\22360 sickle cell trait (HbAS) 78 crisis 532 test, positive (solubility test) 40 sickling disorders 72 \200\2234 skin 324 thalidomide 628 thrombocythaemia, essential 250 \200\2233 thrombocytopenia 384 \200\2235, 3 86, 392 \200\2233 with absent radius syndrome 458 amegakaryocytic 458 autoimmune 392 drug-i nduced 392 \200\2233 gestational 392 heparin-induced 520 \200\2231 hereditary 385 immune 38 8 \200\2239 neonatal alloimmune 392, 448 \200\2239 non-immune 392 in pregnancy 36 thrombocy tosis 382 reactive 254, 382 thromboembolism 405 lesions, infected, erythematous margins of 4 sodium chlorate 496 solitary plasmacytoma of bone 282 specialist centers 472 support 355 spherocytosis, hereditary 98 \200\2239 spinal collapse 526 spleen 73 splenectomy 177, 179, 258, 389, 582 \200\2233 splenic irradiation 177, 258 lymphoma with villous lymphocytes (SLVL) 182 recurrent 26 venous 404 \200\2235 thrombolysis 328 thrombolytic therapy, overdosage of splenomegaly 6 spontaneous inhibitors 366 \200\2237 5q \200\223 syndrome 228 starvation 66 stem cell transplantation see under 516 thrombopathy, drug induced 371 thrombophilia 394 \200\2235 acquired 400 \200\2231 inherited 396 \200\2238 transplantation stem cells, manipulation of 317 steroids 574 storage disorders 496 supporti ve thrombosis arterial 253 recurrent 398 see also haemostasis and thrombosis care 290, 536 \200\22340 management 179 treatment 244 707 22-OHC2e_index.qxd 10.12.2003 04.37 PM Page 708 thrombotic events, acute 397 \200\2238, 401 thyroid disorders 48 thyrotoxicosis 48 tissue d amage 512 tissue factor, release of 512 T-lymphocyte abnormalities, acquired tumors 470, 471 umbilical cord blood transplants 298 urine paraprotein 32 412, 413 TORCH infections 495 tositusimab 203, 204 transfusion exchange 424 \200\2235 haemosiderosis 130 \200\2231 intrauterine 442 issues 640 \200\2231 r eactions 502 delayed 504 febrile 504 small volume 424 see also blood transfusion transient erythroblastopenia of childhood 454 \200\2235 transplantation 294 \200\223340 VAPEC-B 594 \200\2235 variant CJD 353 vascular defects 25 disorders 512 lesion 345 problems 584 \200\2235 vaso-occlusion 72 venepuncture 5 64 venesection 243, 566 veno-occlusive disease 328 venous access 584 vesicants 578 vinblast ine 596, 598, 602 vincristine 594, 600, 604, 614, 622, allogeneic 336 BMT/Peripheral blood stem cell transplant 302 \200\2233 bone marrow harvesti ng 304 \200\2235 CMV prophylaxis and treatment 624 334 \200\2235 adriamycin dexamethasone regimen discharge and follow-up 340 fungal infections, invasive and 278, 624 viral antifungal therapy 330 \200\2232 cytomegalovirus 557 HSV/HZV 557 infection 96 RSV 557 GvHD, acute 324 \200\2235 GvHD, chronic 326 \200\2237 GvHD prophylaxis 320 \200\2232 post-t ransplant vaccination virology 302, 544 vitamin program 336 \200\2237 relapse post-allogeneic SCT, A deficiency 66 B6 (pyridoxine) deficiency 66 B12 deficiency 60 \200\2231 C deficiency 66 E deficiency 66 K 360 \200\2231, 522 treatment of 338 stem cell 177, 279, 294 \200\2235 allogeneic 258, 279, 287, 296 \200\2238 autologous 279, 287, 300 \200\2231, 336 blood produ ct support for von Willebrand \200\231s disease 348 \200\22350, 367 voriconazole 331 316 \200\22318 conditioning regimens 310 cryopreservation 308, 312 \200\22313 fresh non-cryopreserved 314 peripheral blood, mobilization and harvesting 306 \200\2237 Waldenstr m \200\231s macroglobulinaemia veno-occlusive disease 328 32, 284 \200\2237, 510 \200\22311 trephine biopsy 169 tuberculosis 557 tumor lysis syndrome, acute 560 \200\2231 warfarin 402 708 overdosage 522 22-OHC2e_index.qxd 10.12.2003 04.37 PM Page 709 white blood cell 422 white blood count 510 production failure 562 see also white blood cell elevated 14 \200\22315 reduced 16 \200\22318 abnormalities; white blood count Wilson \200\231s disease 97, 494 Wiskott-Aldrich syndrome 409 World Health Organization 151 \200\2232, white blood cell abnormalities 134 \200\22346 basopenia 142 basophilia 142 eosinophilia 140 lymphocytosis 138 lymphopenia 138 monocytopen ia 144 monocytosis 144 mononucleosis syndromes 146 neutropenia 136 \200\2237 neutrophilia 1 34 220 \200\2232, 234, 238, 260, 678, 680 x-linked agammaglobulinaemia 410 Z-DEX 626 709