What is the effect of blood pressure lowering on outcome incidence in hypertension?
Studies have shown that blood pressure lowering has a positive impact on the incidence of outcomes in hypertension. This has been demonstrated in several meta-analyses of randomized trials, including Thomsonopoulos et al. (2014), Thompson et al. (2011), Thomopoulos et al. (2016), Verdecchia et al. (2016), Bangalore et al. (2017), Bundy et al. (2017), Ruggenenti et al. (2005), Wright et al. (2002), and Upadhyay et al. (2011). These meta-analyses have shown that blood pressure lowering can reduce the risk of cardiovascular disease and mortality, as well as protect against progression of hypertensive kidney disease. In addition, the studies have identified that different blood pressure levels may have different effects, suggesting that achieving optimal blood pressure levels is important in reducing the incidence of outcomes in hypertension.   