6/28/23, 12:17 AM CORAL Pathway Feedback Search Clinical Topics Home Studies CORAL CORAL Disease Disease Disease Chronic kidney disease Hypertension Renal a Trial question What is the role of renal artery stenting in people with atherosclerotic renal artery stenosis and hypertension or CKD? Study design Multi-center Open label RCT Population Characteristics of study participants 50.0% female N = 947 50.0% male 947 patients (466 female, 465 male) Inclusion criteria: people with atherosclerotic renal artery stenosis and either systolic hypertension while taking 2 antihypertensive drugs or CKD Key exclusion criteria: renal artery stenosis due to FMD, CKD from a cause other than ischemic nephropathy or associated with a serum creatinine level > 4.0 mg/dL, kidney length < 7 cm, and a lesion that could not be treated with the use of a single stent Interventions N=467 renal artery stenting plus medical therapy (placement of a Palmaz Genesis stent (Cordis) plus candesartan, hydrochlorothiazide, and atorvastatin-amlodipine) N=480 medical therapy alone (with candesartan, hydrochlorothiazide, and atorvastatin- amlodipine) Primary outcome https://web.pathway.md/studies/rec2WNf51FYMPxySj 1/2 6/28/23, 12:17 AM CORAL Pathway Death from any cause 16.1 % 16.1 13.7 12.1 % 8.1 % 4.0 % No significant difference 0.0 % Renal artery stenting plus medical therapy Medical therapy alone No significant difference in death from any cause (13.7% vs. 16.1%; HR 0.8, 95% CI 0.58 to 1.12) Secondary outcomes No significant difference in stroke (3.5% vs. 4.9%; HR 0.68, 95% CI 0.36 to 1.28) No significant difference in progressive renal insufficiency (16.8% vs. 18.9%; HR 0.86, 95% CI 0.64 to 1.17) Conclusion In people with atherosclerotic renal artery stenosis and either systolic hypertension while taking 2 antihypertensive drugs or CKD, renal artery stenting plus medical therapy was not superior to medical therapy alone with respect to death from any cause. Reference Cooper CJ, Murphy TP, Cutlip DE et al. Stenting and medical therapy for atherosclerotic renal- artery stenosis. N Engl J Med. 2014 Jan 2;370(1):13-22. Open reference URL https://web.pathway.md/studies/rec2WNf51FYMPxySj 2/2