What was the result of the VITATOPS trial regarding the effects of B vitamin supplementation on the risk of stroke?
The VITATOPS trial, which included 8164 subjects with recent stroke or TIA who were randomized to vitamin B6, vitamin B12 and folic acid versus placebo and followed up for a median of 3.4 years, found no effect of B vitamin supplementation on risk of stroke (HR, 0.92; 95% CI, 0.81 1.06).