6/27/23, 11:49 PM Breast cancer recurrence Pathway Feedback Search Clinical Topics Home Studies Breast cancer recurrence Breast cancer recurrence Trial question What is the role of regional anesthesia-analgesia in breast cancer recurrence after potentially curative surgery? Study design Multi-center Open label RCT Population 2132 female patients Inclusion criteria: women aged < 85 years having potentially curative primary breast cancer resections Key exclusion criteria: previous surgery for breast cancer (except diagnostic biopsies), inflammatory breast cancer, scheduled free-flap reconstruction, contraindications to either anesthetic approach or analgesic, or other cancer not in long-term remission Interventions N=1043 regional anesthesia-analgesia (paravertebral blocks and propofol) N=1065 general anesthesia (sevoflurane and opioid analgesia) Primary outcome Local or metastatic breast cancer recurrence 10.0 % 10 10 7.5 % 5.0 % 2.5 % No significant difference 0.0 % Regional anesthesia-analgesia General anesthesia No significant difference in local or metastatic breast cancer recurrence (10% vs. 10%; HR 0.97, 95% CI 0.74 to 1.28) Secondary outcomes No significant difference in incisional pain at 6 months and 12 months (52% vs. 52%; aOR 1, 95% CI 0.85 to 1.17) Safety outcomes https://web.pathway.md/studies/recWdCHyDexCO3Ztz 1/2 6/27/23, 11:49 PM Breast cancer recurrence Pathway y No significant differences in quality of life as assessed by scores on SF-12, death. Significant difference in postoperative nausea (8% vs. 20%). Conclusion In women aged < 85 years having potentially curative primary breast cancer resections, regional anesthesia-analgesia was not superior to general anesthesia with respect to local or metastatic breast cancer recurrence. Reference Daniel I Sessler, Lijian Pei, Yuguang Huang et al. Recurrence of breast cancer after regional or general anaesthesia: a randomised controlled trial. Lancet. 2019 Nov 16;394(10211):1807-1815. Open reference URL https://web.pathway.md/studies/recWdCHyDexCO3Ztz 2/2