6/28/23, 11:10 PM Home Sleep and Metabolism Pathway Feedback Search Clinical Topics Home Studies Home Sleep and Metabolism Home Sleep and Metabolism Disease Obesity Trial question What is the effect of sleep extension among adults with overweight who habitually decreased their sleep duration? Study design Single center Open label RCT Population Characteristics of study participants 49.0% female N = 80 51.0% male 80 patients (39 female, 41 male) Inclusion criteria: overweight adults with habitual sleep duration < 6.5 hours per night Key exclusion criteria: obstructive sleep apnea; insomnia or history of any other sleep disorder; night shift; rotating shift work; participants following a weight-loss regimen Interventions N=40 sleep extension (sleep hygiene counseling aiming to extend sleep duration to 8.5 hours for 2 weeks) N=40 habitual sleep (continued habitual sleep without intervention for 2 weeks) Primary outcome Significant decrease in energy intake (-155.5 kcal/d vs. 114.9 kcal/d; AD -270.4 kcal/d, 95% CI -393.4 to -147.4) t https://web.pathway.md/studies/recKbsSr56idt7elq S d 1/2 6/28/23, 11:10 PM Home Sleep and Metabolism Pathway Secondary outcomes No significant difference in total energy expenditure (-46.7 kcal/d vs. 7.2 kcal/d; AD -53.9 kcal/d, 95% CI -134.9 to 27.1) Significant decrease in weight (-0.48 kg vs. 0.39 kg; AD -0.87 kg, 95% CI -1.39 to -0.35) Significant decrease in fat-free mass (-0.36 kg vs. 0.26 kg; AD -0.62 kg, 95% CI -1.02 to -0.23) Conclusion In overweight adults with habitual sleep duration < 6.5 hours per night, sleep extension was superior to habitual sleep with respect to energy intake. Reference Esra Tasali, Kristen Wroblewski, Eva Kahn et al. Effect of Sleep Extension on Objectively Assessed Energy Intake Among Adults With Overweight in Real-life Settings: A Randomized Clinical Trial. JAMA Intern Med. 2022 Apr 1;182(4):365-374. Open reference URL https://web.pathway.md/studies/recKbsSr56idt7elq 2/2