6/28/23, 10:56 PM GREAT Pathway Feedback Search Clinical Topics Home Studies GREAT GREAT Trial question Are second-generation hydrogel coils superior to bare platinum coils in patients with small-to- medium-sized intracranial aneurysms? Study design Multi-center Open label RCT Population Characteristics of study participants 69.0% female N = 484 31.0% male 484 patients (333 female, 151 male) Inclusion criteria: adult patients with untreated small-to-medium-sized intracranial aneurysms Key exclusion criteria: previous randomization in the trial; treatment of > 1 aneurysm in the same treatment episode; previous treatment of aneurysm by coiling or clipping Interventions N=243 hydrogel coil (endovascular embolization with second-generation hydrogel coils) N=241 bare platinum coil (endovascular embolization with bare platinum coils) Primary outcome Percentage of patients with unfavorable angiographic and clinical events 28.7 % 28.7 21.5 % 19.9 14.3 % Significant decrease 7.2 % NNT = 11 0.0 % Hydrogel coil Bare platinum coil https://web.pathway.md/studies/recB7D4V9Voejk9PE 1/2 6/28/23, 10:56 PM GREAT Pathway Significant decrease in the percentage of patients with unfavorable angiographic and clinical events (19.9% vs. 28.7%; ARD -8.4, 95% CI -16.2 to -0.5) Secondary outcomes Significant increase in the achievement of a greater aneurysm packing density (39% vs. 31%; AD 8%, 95% CI 3.25 to 12.75) No significant difference in death from any cause at day 14 (2% vs. 2.1%; ARD -0.1, 95% CI -3.1 to 3.2) Safety outcomes No significant difference in procedural complications; adverse events at 18 months. Conclusion In adult patients with untreated small-to-medium-sized intracranial aneurysms, hydrogel coil was superior to bare platinum coil with respect to the percentage of patients with unfavorable angiographic and clinical events. Reference Christian A Taschner, Ren Chapot, Vincent Costalat et al. Second-Generation Hydrogel Coils for the Endovascular Treatment of Intracranial Aneurysms: A Randomized Controlled Trial. Stroke. 2018 Mar;49(3):667-674. Open reference URL https://web.pathway.md/studies/recB7D4V9Voejk9PE 2/2