What trials have been conducted to assess the efficacy of ACE inhibitors on reducing mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction?
Trials conducted to assess the efficacy of ACE inhibitors on reducing mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction include the Survival and Ventricular Enlargement Trial (SAVE) conducted by Pfeffer et al. in 1992, the Fourth International Study of Infarct Survival (ISIS-4) conducted by the ISIS-4 Collaborative Group in 1995, and the ACE Inhibitor Myocardial Infarction Collaborative Group conducted in 1998. All three trials concluded that ACE inhibitors can reduce the incidence of heart failure and mortality after an acute coronary syndrome. 