What effect does simvastatin 80 mg daily combined with ezetimibe 10 mg daily have on carotid intima-media thickness and plasma lipoproteins?
A large placebo-controlled RCT examined the effect of simvastatin 80 mg daily, with or without ezetimibe 10 mg daily, on carotid intima-media thickness and plasma lipoproteins over 2 years. Mean LDL-C reduction was greater in the combined-therapy group, but there was no difference in carotid intima-media thickness between the 2 groups.