6/30/23, 2:15 AM TAVA Pathway Feedback Search Clinical Topics Home Studies TAVA TAVA Trial question Is tranexamic acid superior to adrenaline in controlling iatrogenic bleeding during flexible bronchoscopy? Study design Single center Double blinded RCT Population Characteristics of study participants 36.0% female N = 130 64.0% male 130 patients (47 female, 83 male) Inclusion criteria: patients with bleeding during flexible bronchoscopy that was not controlled successfully after 3 applications of 5 mL of cold saline Key exclusion criteria: all relevant relative and absolute contraindications for flexible bronchoscopy and topical use of adrenaline Interventions N=65 tranexamic acid (topical instillation of 100 mg tranexamic acid per application; receipt of up to 3 applications) N=65 adrenaline (topical instillation of 0.2 mg adrenaline per application; receipt of up to 3 applications) Primary outcome Successfully controlled bleeding 83.1 % 83.1 83.1 62.3 % 41.5 % https://web.pathway.md/studies/rec7EnyGGzTlkc8PM 1/2 6/30/23, 2:15 AM TAVA Pathway 5 % 20.8 % No significant difference 0.0 % Tranexamic acid Adrenaline No significant difference in successfully controlled bleeding (83.1% vs. 83.1%; RR 1, 95% CI -76794.23 to 76796.23) Secondary outcomes No significant difference in severe bleeding episodes (18.5% vs. 7.7%; RR 2.4, 95% CI -8.89 to 13.69) No significant difference in the number of applications needed for bleeding control after crossover (2 vs. 2.2; RR 0.91, 95% CI -2.14 to 3.96) Safety outcomes No significant difference in serious adverse events. Conclusion In patients with bleeding during flexible bronchoscopy that was not controlled successfully after 3 applications of 5 mL of cold saline, tranexamic acid was not superior to adrenaline with respect to successfully controlled bleeding. Reference Sonja Badovinac, Goran Glodi , Ivan Sabol et al. Tranexamic Acid vs Adrenaline for Controlling Iatrogenic Bleeding During Flexible Bronchoscopy: A Double-Blind Randomized Controlled Trial. Chest. 2023 Apr;163(4):985-993. Open reference URL https://web.pathway.md/studies/rec7EnyGGzTlkc8PM 2/2