What are the prognostic implications of changes in N-Terminal Pro-B-Type Natriuretic Peptide levels in patients with heart failure?
Research has shown that changes in N-Terminal Pro-B-Type Natriuretic Peptide (NT-proBNP) levels in patients with heart failure can have important prognostic implications. A 2015 study by Zile et al. found that higher NT-proBNP levels at baseline and greater increases in NT-proBNP over time were associated with worse outcomes, including higher rates of death or hospitalization due to heart failure. This indicates that measuring NT-proBNP levels in heart failure patients can be a useful tool in predicting the risk of clinical progression and poor outcomes. 