What were the effects of amlodipine-based therapy in patients with diabetes mellitus compared to atenolol-based therapy?
The effects of amlodipine-based therapy in patients with diabetes mellitus compared to atenolol-based therapy were studied in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT). The results showed that the amlodipine-based therapy reduced the incidence of total cardiovascular events and procedures compared to the atenolol-based regimen, with a 9% reduction in the risk of a composite of major macrovascular and microvascular events (HR, 0.91; 95% CI, 0.83 1.00; P=0.04) and a significant reduction (P=0.017) in fatal and nonfatal strokes. 