6/28/23, 10:39 PM FLASH-UK Pathway Feedback Search Clinical Topics Home Studies FLASH UK FLASH UK Disease Diabetes mellitus type 1 Trial question What is the role of intermittently scanned continuous glucose monitoring in patients with T1DM? Study design Multi-center Open label RCT Population Characteristics of study participants 44.0% female N = 156 56.0% male 156 patients (69 female, 87 male) Inclusion criteria: adult participants with T1DM and glycated Hgb levels between 7.5-11.0% Key exclusion criteria: current use of real-time continuous glucose monitors or intermittently scanned continuous glucose monitoring for > 4 weeks within the previous 12 weeks; pregnancy or planned pregnancy; and complete loss of awareness of hypoglycemia Interventions N=78 flash glucose monitoring (intermittently scanned continuous glucose monitoring with free style libre 2 device) N=78 self-monitoring of blood glucose (monitoring own blood glucose levels with fingerstick testing) Primary outcome Glycated hemoglobin level at 24 weeks 8.3 8 3 % 7 9 https://web.pathway.md/studies/recdV4yxtXoOocrMX 1/2 6/28/23, 10:39 PM FLASH-UK Pathway 8.3 % 7.9 6.2 % 4.2 % Significant decrease 2.1 % NNT = 250 0.0 % Flash glucose monitoring Self-monitoring of blood glucose Significant decrease in glycated Hgb level at 24 weeks (7.9% vs. 8.3%; ARD -0.5, 95% CI -0.7 to -0.3) Secondary outcomes Significant increase in the percentage of time spent in target glucose range of 70-180 mg/dL at week 24 (52.1% vs. 45.2%; AD 9%, 95% CI 4.7 to 13.3) Significant decrease in time spent in hypoglycemia at week 24 (3.5% vs. 6.5%; ARD -3, 95% CI -4.5 to -1.4) Significant decrease in time spent in hyperglycemia at week 24 (44.5% vs. 48.3%; ARD -6, 95% CI -11 to -0.9) Safety outcomes No significant difference in adverse and serious adverse events. Conclusion In adult participants with T1DM and glycated Hgb levels between 7.5-11.0%, flash glucose monitoring was superior to self-monitoring of blood glucose with respect to glycated Hgb level at 24 weeks. Reference Lalantha Leelarathna, Mark L Evans, Sankalpa Neupane et al. Intermittently Scanned Continuous Glucose Monitoring for Type 1 Diabetes. N Engl J Med. 2022 Oct 20;387(16):1477- 1487. Open reference URL https://web.pathway.md/studies/recdV4yxtXoOocrMX 2/2