What is the efficacy of teicoplanin and cefazolin prophylaxis in cardiac operations?
The efficacy of teicoplanin and cefazolin for cardiac operation prophylaxis was compared in a double-blind randomized trial of 3027 patients. The results of the study indicated that the two antibiotics had similar efficacy in terms of preventing infection and other complications. Specifically, Saginur et al. (2000) reported that the rate of postoperative wound infections following cardiac operations was comparable with both teicoplanin (3.1%) and cefazolin (3.6%) prophylaxis.