What is the importance of doubling of SCr level or halving of GFR in studies where SCr was 42 mg/dl (4177 mmol/l)?
Doubling of SCr level or halving of GFR was upgraded from high to critical importance in studies where SCr was 42 mg/dl (4177 mmol/l) due to the known adverse consequences of advanced CKD. This upgrade was based on evidence from the KDOQI Clinical Practice Guidelines on Hypertension and Antihypertensive Agents in Chronic Kidney Disease. The guideline includes systematic reviews on topics such as diet or lifestyle modification, blood pressure targets, and anti-hypertensive agents. The reviews considered randomized controlled trials with parallel-group designs, a minimum duration of follow-up of 6 weeks for blood pressure, 3 months for proteinuria, and 1 year for other outcomes, and a minimum of 50 participants per arm.