What are the recommended treatments for IE caused by S pyogenes and group B, C, or G streptococci?
For IE caused by S pyogenes, 4 to 6 weeks of therapy with aqueous crystalline penicillin G or ceftriaxone is reasonable; vancomycin is reasonable only in patients intolerant of -lactam therapy. For IE caused by group B, C, or G streptococci, the addition of gentamicin to aqueous crystalline penicillin G or ceftriaxone for at least the first 2 weeks of a 4- to 6-week treatment course may be considered.