What were the results of the ACTIVE-A trial comparing aspirin plus clopidogrel and aspirin monotherapy?
The ACTIVE-A trial found that dual antiplatelet therapy (DAPT) with aspirin plus clopidogrel was associated with a decrease in stroke risk compared to aspirin monotherapy, but the major bleeding rates with aspirin-clopidogrel were similar to those of warfarin (approximately 2% per year).