What is the quality of the evidence comparing ACEi or ARB with placebo or standard of care in patients with CKD and severely increased albuminuria without diabetes?
The overall quality of the evidence comparing ACEi or ARB with placebo or standard of care in patients with CKD and severely increased albuminuria without diabetes is moderate. The quality of the evidence was down- graded because of study limitations, such as small numbers of events, inadequate reporting of sequence generation, and allocation concealment (Supplementary Table S15176 179,188,188a,189 and Supplementary Table S16190,191).