6/28/23, 12:13 AM COAPT Pathway Feedback Search Clinical Topics Home Studies COAPT COAPT Disease Disease Heart failure Mitral regurgitation Trial question What is the role of transcatheter mitral valve repair in patients with HF and symptomatic moderate-to-severe or severe secondary MR? Study design Multi-center Open label RCT Population Characteristics of study participants 36.0% female N = 614 64.0% male 614 patients (219 female, 393 male) Inclusion criteria: patients with HF and symptomatic moderate-to-severe or severe secondary MR despite the use of maximal doses of guideline-directed medical therapy Key exclusion criteria: untreated clinically significant coronary artery disease requiring revascularization, CABG, PCI or TAVR within the prior 30 days, cerebrovascular accident within prior 30 days, severe symptomatic carotid stenosis, carotid surgery or stenting within prior 30 days Interventions N=302 transcatheter mitral valve repair (with MitraClip device within 14 days after randomization plus guideline-directed medical therapy) N=312 control (guideline-directed medical therapy alone) Primary outcome https://web.pathway.md/studies/recmgeqzmLkCrS0xy 1/2 6/28/23, 12:13 AM COAPT Pathway All hospitalizations for heart failure within 24 months 67.9 % / p-y 67.9 50.9 % / p-y 35.8 34.0 % / p-y 17.0 % / p-y Significant decrease 0.0 % / p-y Transcatheter mitral valve repair Control Significant decrease in all hospitalizations for HF within 24 months (35.8% / p-y vs. 67.9% / p-y; HR 0.53, 95% CI 0.4 to 0.7) Secondary outcomes Significant decrease in death from any cause at 2 years (29.1% vs. 46.1%; HR 0.62, 95% CI 0.46 to 0.82) Conclusion In patients with HF and symptomatic moderate-to-severe or severe secondary MR despite the use of maximal doses of guideline-directed medical therapy, transcatheter mitral valve repair was superior to control with respect to all hospitalizations for HF within 24 months. Reference Stone GW, Lindenfeld J, Abraham WT et al. Transcatheter Mitral-Valve Repair in Patients with Heart Failure. N Engl J Med. 2018 Dec 13;379(24):2307-2318. Open reference URL https://web.pathway.md/studies/recmgeqzmLkCrS0xy 2/2