What are the effects of tissue plasminogen activator, streptokinase, or both on coronary-artery patency, ventricular function, and survival after acute myocardial infarction?
The GUSTO Angiographic Investigators studied the effects of tissue plasminogen activator, streptokinase or both on coronary-artery patency, ventricular function and survival after acute myocardial infarction. The results of their study, published in the New England Journal of Medicine in 1993, showed that the combination of tissue plasminogen activator and streptokinase improved patency, ventricular function and survival after acute myocardial infarction compared to either agent alone. However, it was also noted that the combination was associated with a higher risk of bleeding than either agent alone. 