6/28/23, 11:16 PM METEOR Pathway Feedback Search Clinical Topics Home Studies METEOR METEOR Trial question What is the role of surgery in symptomatic patients with a meniscal tear and knee OA? Study design Multi-center Open label RCT Population Characteristics of study participants 56.4% female N = 351 43.6% male 351 patients (187 female, 143 male) Inclusion criteria: symptomatic patients 45 years of age with a meniscal tear and evidence of mild-to-moderate OA on imaging Key exclusion criteria: chronically locked knee, inflammatory arthritis or clinically symptomatic chondrocalcinosis, injection with viscosupplementation, contraindication to surgery or physical therapy, bilateral symptomatic meniscal tear, or prior surgery on index knee Interventions N=161 surgical meniscectomy (arthroscopic partial meniscectomy and postoperative physical therapy) N=169 physical therapy alone (standardized physical-therapy regimen) Primary outcome Mean improvement in WOMAC score at 6 months 20.9 points 20.9 18.5 15.7 points 10.4 points https://web.pathway.md/studies/recDKfqzeYUjMykC4 1/2 6/28/23, 11:16 PM METEOR Pathway 5.2 points No significant difference 0.0 points Surgical meniscectomy Physical therapy alone No significant difference in mean improvement in the WOMAC score at 6 months (20.9 points vs. 18.5 points; MD 2.4, 95% CI -1.8 to 6.5) Secondary outcomes No significant difference in mean improvement in the KOOS pain score after 6 months (24.2 vs. 21.3; MD 2.9, 95% CI -1.2 to 7) No significant difference in mean improvement in the SF-36 physical-activity score after 6 months (24.2 vs. 23.1; MD 1.1, 95% CI -4.4 to 6.6) Safety outcomes No significant difference in adverse events. Conclusion In symptomatic patients 45 years of age with a meniscal tear and evidence of mild-to-moderate OA on imaging, surgical meniscectomy was not superior to physical therapy alone with respect to mean improvement in the WOMAC score at 6 months. Reference Katz JN, Brophy RH, Chaisson CE et al. Surgery versus physical therapy for a meniscal tear and osteoarthritis. N Engl J Med. 2013 May 2;368(18):1675-84. Open reference URL https://web.pathway.md/studies/recDKfqzeYUjMykC4 2/2