What are the effects of spironolactone in patients with heart failure and preserved ejection fraction?
In a study conducted by Pitt et al. (2014), spironolactone was found to be effective in reducing mortality and hospitalization rates in patients with heart failure and preserved ejection fraction. The study also found that spironolactone was associated with improved symptoms and quality of life. Furthermore, spironolactone was found to be well tolerated in patients with heart failure and preserved ejection fraction, with no significant increase in adverse events.  