What is the recommendation for hemodilution by volume expansion for treatment of patients with AIS?
Hemodilution by volume expansion is not recommended for treatment of patients with AIS. This recommendation is unchanged from the 2013 AIS Guidelines and conforms to the ACC/AHA 2015 Recommendation Classification System. A recent Cochrane review of 4174 participants from multiple RCTs confirmed the previous guideline recommendation that hemodilution therapy, including varying methods of volume expansion with or without venesection, demonstrates no significant benefit in patients with AIS.231