What is the relationship between dyslipidemias and atherosclerotic clinical events in children with CKD?
The relationship between dyslipidemias and subsequent atherosclerotic clinical events in children with CKD is not known due to short follow-up in observational studies or clinical trials. The Cardiovascular Risk Reduction in High-Risk Pediatric Patients: A Scientific Statement from the American Heart Association Expert Panel on Population and Prevention Science stated that CVD prevention in many chronic pediatric conditions was warranted given the high risk of developing disease as adults. The National Institutes of Health Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents in 2011 addressed specific questions of screening for dyslipidemias in children and adolescents and also treatment of dyslipidemias. Lipid levels vary depending on age, puberty, and gender. Former guidelines used the 95th percentile for age and gender to determine the upper limit of acceptable values, while more recent guidelines have used age- and gender- specific curves for lipoproteins linked to CVD risk over 15-20 years.