What is the significance of Troponin measurements in diagnosing Acute Myocardial Necrosis?
The troponin measurements are highly sensitive and specific for detecting cardiomyocyte necrosis. For diagnosis of acute myocardial necrosis, it is important to determine not only the peak troponin value, but also serial changes, such as a troponin value above the 99th percentile of the upper reference level, or a change of 3 standard deviations of the variation around the initial value. Additionally, evidence for a serial increase or decrease of 20% is required if the initial value is elevated.