In adults with CKD without diabetes, what is the association between reducing dietary salt intake compared to usual dietary salt intake and clinically relevant outcomes and adverse effects?
A Cochrane review by McMahon et al. (2020) evaluated the association between reducing dietary salt intake compared to usual dietary salt intake and clinically relevant outcomes and adverse effects in adults with CKD without diabetes. The review concluded that low-salt diets had a small beneficial effect on blood pressure, but there was insufficient evidence to determine the effect on other outcomes such as sodium excretion, serum creatinine, and adverse effects. The review also found that there was no difference in adverse effects between low-salt diets and usual-salt diets. Therefore, it is unclear if reducing dietary salt intake has a beneficial effect on clinically relevant outcomes and adverse effects in adults with CKD without diabetes. 