What evidence suggests that LAA occlusion might be a safe and effective option for patients with a contraindication to long-term oral anticoagulation after ICH?
Observational data from 1,025 patients suggest that LAAO might be safe and effective in patients with a contraindication to long-term oral anticoagulation, but only a minority of patients (15%) in this study had suffered ICH.346 Small studies of ICH survivors suggest that LAAO, using antiplatelet treatment as periprocedural antithrombotic treatment, is safe and effective in this population, including those Randomized trials of LAAO, ideally in comparison to NOACs, are needed to de nitively determine the safety and ef cacy of each approach in ICH survivors.