6/28/23, 10:11 PM Early Mobilization in the ICU Pathway Feedback Search Clinical Topics Home Studies Early Mobilization in the ICU Early Mobilization in the ICU Trial question What is the effect of early mobilization in ICU patients after mechanical ventilation? Study design Single center Open label RCT Population Characteristics of study participants 43.0% female N = 198 57.0% male 198 patients (85 female, 113 male) Inclusion criteria: adult patients who were functionally independent and mechanically ventilated Key exclusion criteria: rapidly changing neurological conditions; cardiac arrest as cause of respiratory failure; elevated ICP; pregnancy; terminal condition; TBI Interventions N=99 early mobilization (early physical therapy occupational therapy delivered by a team consisting of physical and occupational therapists) N=99 standard care (physical therapy occupational therapy delivered as ordered by the primary ICU team) Primary outcome Rate of cognitive impairment 1 year after hospital discharge 43.0 % 43 32.3 % 24 21.5 % Significant decrease 10.8 % NNT = 5 0.0 % https://web.pathway.md/studies/recN7G69rXEyLO2g3 1/2 6/28/23, 10:11 PM Early Mobilization in the ICU Pathway Early mobilization Standard care Significant decrease in the rate of cognitive impairment 1 year after hospital discharge (24% vs. 43%; ARD -19.2, 95% CI -32.1 to -6.3) Secondary outcomes Significant increase in Montreal Cognitive Assessment score at 1 year (26 vs. 23; AD 3, 95% CI 1 to 4) Significant decrease in cognitive impairment at hospital discharge (54% vs. 69%; ARD -15.2, 95% CI -28.6 to -1.7) Significant decrease in ICU-acquired weakness at 1 year (ARD -14.1, 95% CI -21 to -7.3) Safety outcomes Significant difference in adverse events (6% vs. 0%). Conclusion In adult patients who were functionally independent and mechanically ventilated, early mobilization was superior to standard care with respect to the rate of cognitive impairment 1 year after hospital discharge. Reference Bhakti K Patel, Krysta S Wolfe, Shruti B Patel et al. Effect of early mobilisation on long-term cognitive impairment in critical illness in the USA: a randomised controlled trial. Lancet Respir Med. 2023 Jun;11(6):563-572. Open reference URL https://web.pathway.md/studies/recN7G69rXEyLO2g3 2/2