What is the recommendation regarding observation after IV alteplase to assess for clinical response in patients under consideration for mechanical thrombectomy?
Among 390 patients who achieved substantial reperfusion with endovascular thrombectomy, each 1-hour delay to reperfusion was associated with a less favorable degree of disability. Therefore, the recommendation is to avoid any cause for delay to mechanical thrombectomy, including observing for a clinical response after IV alteplase.