What was the committee concerned about regarding the proportion of HF-REF patients in the study?
The committee was concerned that the low proportion of HF-REF patients identified in the study may bias the model results, as there would be greater clinical benefit to diagnosing heart failure the greater the benefit of earlier detection and therefore a lower NT-proBNP threshold. They also acknowledged that were there clinically effective treatment for HF-PEF patients, then a lower NT-proBNP threshold is likely to be most cost effective.