6/28/23, 9:53 PM EMERGE Pathway Feedback Search Clinical Topics Home Studies EMERGE EMERGE Disease Cardiac arrest Trial question Is emergency coronary angiogram superior to delayed coronary angiogram in survivors of out-of- hospital cardiac arrest? Study design Multi-center Open label RCT Population Characteristics of study participants 30.0% female N = 279 70.0% male 279 patients (84 female, 195 male) Inclusion criteria: survivors of out-of-hospital cardiac arrest without ST-segment elevation on ECG Key exclusion criteria: age < 18 years; pregnancy; no ROSC; in-hospital sudden cardiac death; presence of ST-segment elevation; suspected noncardiac etiology Interventions N=138 emergency coronary angiogram (immediate coronary angiogram at the time of hospital admission) N=137 delayed coronary angiogram (coronary angiogram delayed between 48 and 96 hours after hospital admission) Primary outcome Survival with cerebral performance category of 2 at day 180 https://web.pathway.md/studies/recfrX1pOKQqdsowU 1/2 6/28/23, 9:53 PM EMERGE Pathway 34.1 % 34.1 30.7 25.6 % 17.1 % 8.5 % No significant difference 0.0 % Emergency coronary angiogram Delayed coronary angiogram No significant difference in survival with cerebral performance category of 2 at day 180 (34.1% vs. 30.7%; HR 1.15, 95% CI 0.87 to 1.54) Secondary outcomes No significant difference in survival at 180 days (36.2% vs. 33.3%; HR 1.16, 95% CI 0.87 to 1.56) No significant difference in survival with cerebral performance category of 2 at day 90 (28.4% vs. 24.6%; HR 1.16, 95% CI 0.88 to 1.56) No significant difference in shock during the first 24 hours (38.8% vs. 39.8%; HR 1.03, 95% CI 0.72 to 1.32) Safety outcomes No significant differences in VT, ventricular febrillation. Conclusion In survivors of out-of-hospital cardiac arrest without ST-segment elevation on ECG, emergency coronary angiogram was not superior to delayed coronary angiogram with respect to survival with cerebral performance category of 2 at day 180. Reference Caroline Hauw-Berlemont, Lionel Lamhaut, Jean-Luc Diehl et al. Emergency vs Delayed Coronary Angiogram in Survivors of Out-of-Hospital Cardiac Arrest Results of the Randomized, Multicentric EMERGE Trial. JAMA Cardiol. 2022 Jul 1;7(7):700-707. Open reference URL https://web.pathway.md/studies/recfrX1pOKQqdsowU 2/2