What drugs are available in the US for the treatment of multidrug-resistant E faecium IE?
Linezolid and daptomycin are the only 2 antimicrobial agents currently available in the United States that may be useful for the treatment of multidrug-resistant E faecium IE. Quinupristin-dalfopristin may be active in vitro but only against strains of E faecium and is inactive against E faecalis. Quinupristin-dalfopristin is rarely used because of severe side effects, including intractable muscle pain. Tigecycline is active in vitro against some strains of multidrug-resistant enterococci, but there are minimal published data on its use clinically. The same can be said for tedizolid, which has been released.