6/29/23, 11:45 PM SOME Pathway Feedback Search Clinical Topics Home Studies SOME SOME Disease Disease Disease Cancer-associated thrombosis Deep vein thrombosis Pulmonary Trial question What is the role of screening for occult cancer in patients with unprovoked VTE? Study design Multi-center Open label RCT Population Characteristics of study participants 33.0% female N = 854 67.0% male 854 patients (278 female, 576 male) Inclusion criteria: patients who had a first unprovoked VTE Key exclusion criteria: age < 18 years, allergy to contrast media, a CrCl < 60 mL/min, claustrophobia or agoraphobia, a weight > 130 kg, ulcerative colitis, or glaucoma Interventions N=423 limited occult-cancer screening plus CT (basic blood testing, chest radiography, and screening for breast, cervical, and prostate cancer plus comprehensive CT (CT) of the abdomen and pelvis) N=431 limited occult-cancer screening (basic blood testing, chest radiography, and screening for breast, cervical, and prostate cancer) https://web.pathway.md/studies/rec0WZPvAUMQzTWH3 1/2 6/29/23, 11:45 PM SOME Pathway Primary outcome Occult cancer diagnosis at 1 year 4.5 % 4.5 3.4 % 3.2 2.3 % 1.1 % No significant difference 0.0 % Limited occult-cancer screening plus CT Limited occult-cancer screening No significant difference in occult cancer diagnosis at 1 year (4.5% vs. 3.2%; RR 1.4, 95% CI -1.12 to 3.92) Secondary outcomes No significant difference in mean time to a cancer diagnosis (4 vs. 4.2; RR 0.95, 95% CI -10.48 to 12.38) No significant difference in cancer-related death (0.9% vs. 1.4%; RR 0.64, 95% CI -3.1 to 4.38) No significant difference in missed cancer in the primary outcome analysis (26% vs. 29%; RR 0.9, 95% CI -69114.8 to 69116.6) Conclusion In patients who had a first unprovoked VTE, limited occult-cancer screening plus CT was not superior to limited occult-cancer screening with respect to occult cancer diagnosis at 1 year. Reference Carrier M, Lazo-Langner A, Shivakumar S et al. Screening for Occult Cancer in Unprovoked Venous Thromboembolism. N Engl J Med. 2015 Aug 20;373(8):697-704. Open reference URL https://web.pathway.md/studies/rec0WZPvAUMQzTWH3 2/2