6/28/23, 1:20 AM Deceased ODI to Protect KGF (machine perfusion vs. machine perfusion plus hypothermia) Pathway Feedback Search Clinical Topics Deceased ODI to Protect KGF (machine perfusion vs. machine perfusion plus hypothermia) Home Studies Deceased ODI to Protect KGF (machine perfusion vs. machine perfusion plus hypothermia) Trial question Is combination of hypothermia and machine perfusion superior to machine perfusion alone of the kidney in brain-dead organ donors? Study design Multi-center Double blinded RCT Population Characteristics of study participants 37.6% female N = 989 62.4% male 989 patients (371 female, 619 male) Inclusion criteria: adult brain-dead kidney donors Key exclusion criteria: donation after cardiac death; end-stage kidney disease; or a history of dialysis during terminal hospitalization Interventions N=479 combination therapy (combination of therapeutic hypothermia and machine perfusion) N=510 machine perfusion (ex situ kidney hypothermic machine perfusion) Primary outcome Delayed graft function in kidney transplant recipients 22.0 % 22 19 16.5 % 11.0 % 5.5 % https://web.pathway.md/studies/rec3XoqQdCRAJODAL 1/2 6/28/23, 1:20 AM Deceased ODI to Protect KGF (machine perfusion vs. machine perfusion plus hypothermia) Pathway No significant difference 0.0 % Combination therapy Machine perfusion No significant difference in delayed graft function in kidney transplant recipients (22% vs. 19%; RR 1.09, 95% CI 0.85 to 1.4) Conclusion In adult brain-dead kidney donors, combination therapy was not superior to machine perfusion with respect to delayed graft function in kidney transplant recipients. Reference Darren Malinoski, Christina Saunders, Sharon Swain et al. Hypothermia or Machine Perfusion in Kidney Donors. N Engl J Med. 2023 Feb 2;388(5):418-426. Open reference URL https://web.pathway.md/studies/rec3XoqQdCRAJODAL 2/2