What is the significance of the overall ratings in GRADE?
The overall ratings in GRADE are used to determine the quality of the outcome evidence. The ratings range from High to Very Low, with higher ratings indicating higher quality evidence. High ratings indicate that further research is very unlikely to change confidence in the estimate of effect, while Very Low ratings indicate that any estimate of effect is very uncertain. The reasons for downgrading in each case are specified in the footnotes of the GRADE tables.