What is the evidence that moderate-intensity statin therapy is effective in reducing ASCVD risk in adults 40 to 75 years of age with diabetes mellitus?
A meta-analysis of three randomized controlled trials of moderate statin therapy in large cohorts with diabetes mellitus in this age range showed significant reductions in ASCVD, resulting in a risk level similar to that of people without diabetes mellitus and with no apparent difference in benefit between type 1 and type 2 diabetes mellitus. Therefore, on the basis of a high level of evidence, moderate-intensity statin therapy is indicated in patients 40 to 75 years of age with diabetes mellitus for primary prevention.