6/28/23, 10:56 PM GastroPOC Pathway Feedback Search Clinical Topics Home Studies GastroPOC GastroPOC Disease Disease Acute diarrhea Clostridioides difficile infection Trial question What is the role of syndromic molecular point-of-care testing in patients hospitalized with suspected gastroenteritis? Study design Single center Open label RCT Population Characteristics of study participants 49.0% female N = 277 51.0% male 277 patients (137 female, 140 male) Inclusion criteria: adult patients hospitalized with suspected gastroenteritis Key exclusion criteria: palliative approach being taken by treating clinician, previously included in the study and re-presenting within 30 days after hospital discharge, declination of stool sample or rectal swab Interventions N=137 molecular point-of-care testing (syndromic molecular point-of-care testing of stool or rectal samples) N=140 routine clinical care (stool testing done by standard laboratory testing at the discretion of clinical team) Primary outcome Duration of single-occupancy room isolation https://web.pathway.md/studies/recrPULNQqZeQQ3ua 1/2 6/28/23, 10:56 PM GastroPOC Pathway 2.6 days 2.6 2.0 days 1.8 1.3 days 0.7 days Significant decrease 0.0 days Molecular point-of-care testing Routine clinical care Significant decrease in duration of single-occupancy room isolation (1.8 days vs. 2.6 days; AD -0.8 days, 95% CI -1.3 to -0.3) Secondary outcomes Significant decrease in time to study results (1.7 hours vs. 44.7 hours; AD -43.9 hours, 95% CI -49.3 to -38.4) Significant decrease in time to de-isolation (0.6 days vs. 2.2 days; AD -1.5 days, 95% CI -2.2 to -0.8) Significant increase in antibiotic use (65% vs. 47%; AD 18%, 95% CI 6 to 29) Safety outcomes No significant differences in ICU admission, hospital deaths, readmission and re-presentation within 30 days. Conclusion In adult patients hospitalized with suspected gastroenteritis, molecular point-of-care testing was superior to routine clinical care with respect to duration of single-occupancy room isolation. Reference Nathan J Brendish, Kate R Beard, Ahalya K Malachira et al. Clinical impact of syndromic molecular point-of-care testing for gastrointestinal pathogens in adults hospitalised with suspected gastroenteritis (GastroPOC): a pragmatic, open-label, randomised controlled trial. Lancet Infect Dis. 2023 Apr 25;S1473-3099(23)00066-X. Open reference URL https://web.pathway.md/studies/recrPULNQqZeQQ3ua 2/2