What is the efficacy of Prothrombin Complex Concentrates (PCC) for reversing anticoagulation effects of Vitamin K antagonists?
The efficacy of Prothrombin Complex Concentrates (PCC) for reversing anticoagulation effects of Vitamin K antagonists has been evaluated in a meta-analysis by Dentali et al. (2011). The results of the study showed that PCCs are effective for reversing anticoagulation effects of Vitamin K antagonists, reducing the risk of major bleeding events from 24.6% to 13.8% and significantly reducing the risk of death from 9.1% to 3.5%. However, the study also showed that there is an increased risk of thromboembolic events, suggesting that PCCs should be used with caution and only when medically necessary.