How does Colesevelam affect patients with familial hypercholesterolemia?
Colesevelam has been shown to be effective when added to combination therapy with a statin and ezetimibe in patients with familial hypercholesterolemia. Multiple clinical trials have demonstrated its efficacy in reducing levels of atherogenic lipids and risk of cardiovascular events. Additionally, a Mendelian randomization analysis indicated that bile acid sequestrants may reduce the risk of cardiovascular events. Furthermore, research has shown that it is an effective strategy for predicting cardiovascular events in familial hypercholesterolemia, and is associated with a reduction in LDL-C levels among men with primary elevations of LDL-C levels of 190 mg/dL or above.