7/4/23, 12:11 AM Splenomegaly Pathway Feedback Search Clinical Topics Home Findings Splenomegaly Splenomegaly More common causes Trench fever Malaria infection Castleman disease Schistosomiasis Syphilis infection Beta thalassemia Hereditary spherocytosis Infectious mononucleosis Lymphoma Cat-scratch disease Paragonimiasis Sarcoidosis Psittacosis Less common causes Rubella virus infection Typhus fever Whipple's disease DRESS syndrome Serum sickness https://web.pathway.md/findings/reclC2byUBlCAsUki 1/3 7/4/23, 12:11 AM Splenomegaly Pathway Chronic lymphocytic leukemia Extramedullary hemopoiesis Multiple myeloma Myeloproliferative disorders Babesiosis Viral hepatitis Dengue virus infection Cryoglobulinemia Felty's syndrome Leukemia Systemic lupus erythematosus Hodgkin's lymphoma Toxocariasis Infective endocarditis Hemophagocytic lymphohistiocytosis Hairy cell leukemia Gaucher's disease Bartonellosis Visceral larva migrans Visceral leishmaniasis Myelofibrosis Systemic mastocytosis Adult-onset Still's disease Brucellosis Relapsing fever Uncommon causes https://web.pathway.md/findings/reclC2byUBlCAsUki 2/3 7/4/23, 12:11 AM Splenomegaly Pathway Juvenile-onset Still's disease Splenic sequestration crisis Common variable hypogammaglobulinemia Hereditary neutrophilia https://web.pathway.md/findings/reclC2byUBlCAsUki 3/3