What is the recommended therapeutic range for anticoagulation in patients with antiphospholipid syndrome?
In patients with antiphospholipid syndrome, an INR with a target range of 2 to 3 is preferable over an INR with a range >3, as higher-intensity anticoagulation is not superior in preventing thrombotic events and is associated with a higher risk of hemorrhagic complications. Limited evidence favors anticoagulation with VKA compared with aspirin to reduce recurrent arterial thromboses. The clinical consensus favors using only anticoagulation with VKA for antiphospholipid syndrome treatment, although the role of DOACs is the focus of multiple ongoing and recently completed studies.