What is the efficacy of statins in familial hypercholesterolemia?
Several studies have found that statins are effective in reducing the risk of coronary heart disease in patients with familial hypercholesterolemia. For example, the West of Scotland Coronary Prevention Study found that pravastatin reduced the risk of coronary heart disease by 24% in men with hypercholesterolemia (Shepherd et al., 1995). The long-term cohort study by Versmissen et al. (2008) also found that statin treatment was associated with a significant reduction in the risk of coronary heart disease in familial hypercholesterolemia patients. Furthermore, the Circulation study by Khera et al. (2016) found that statin treatment was associated with a significant reduction in cardiovascular events in patients with familial hypercholesterolemia. In conclusion, statins have been found to be effective in reducing the risk of coronary heart disease in patients with familial hypercholesterolemia.  