What are the side effects of Fondaparinux?
Fondaparinux has low affinity for PF4 and does not cross-react with HIT antibodies. Although there have been isolated case reports of HIT associated with the use of fondaparinux, numerous case reports and case series suggest that this agent can be used to treat patients with HIT. Nonhemorrhagic side effects include drug accumulation in patients with renal insufficiency, the development of antibodies against hirudin in up to 40% of patients, and anaphylaxis if patients with antibodies are re-exposed to hirudin.