What is the risk of ischemic stroke among individuals with migraine with aura?
A meta-analysis of 21 studies (13 case-control and 8 cohort) reported an overall pooled RR of 2.04 (95% CI, 1.72 - 2.36). The risk was greater in migraine with aura (pooled adjusted OR for 7 studies, 2.51; 95% CI, 1.52 - 4.14) compared with the association of ischemic stroke and migraine without aura (pooled adjusted OR for 6 studies, 1.29; 95% CI, 0.92 - 1.81).