What is the difference between BNP and NT-proBNP?
BNP (B-type natriuretic peptide) and NT-proBNP (N-terminal pro-B-type natriuretic peptide) are both natriuretic peptide biomarkers used to establish the presence and severity of HF. In general, both natriuretic peptide biomarker values track similarly, and either can be used in patient care settings as long as their respective absolute values and cutpoints are not used interchangeably. However, BNP, but not NT-proBNP, is a substrate for neprilysin. Therefore, ARNI (angiotensin receptor-neprilysin inhibitor) increases BNP levels, but not NT-proBNP levels.