6/29/23, 11:45 PM SPS3-BP Pathway Feedback Search Clinical Topics Home Studies SPS3 BP SPS3 BP Disease Acute ischemic stroke Trial question What is the effect of targeting lower systolic BPs in patients with recent lacunar stroke? Study design Multi-center Open label RCT Population Characteristics of study participants 37.0% female N = 3020 63.0% male 3020 patients (1117 female, 1903 male) Inclusion criteria: patients with recent lacunar stroke Key exclusion criteria: disabling stroke, previous intracranial hemorrhage (excluding traumatic), or cortical ischemic stroke Interventions N=1501 lower BP target (systolic BP target < 130 mmHg) N=1519 higher BP target (systolic BP target of 130-149 mmHg) Primary outcome Ischemic or hemorrhagic stroke 2.8 % 2.77 https://web.pathway.md/studies/recI8N4lPXRnJlAkq 1/2 6/29/23, 11:45 PM SPS3-BP Pathway 2.25 2.1 % 1.4 % 0.7 % No significant difference 0.0 % Lower blood pressure target Higher blood pressure target No significant difference in ischemic or hemorrhagic stroke (2.25% vs. 2.77%; HR 0.81, 95% CI 0.64 to 1.03) Secondary outcomes Significant decrease in intracerebral hemorrhage (0.11% vs. 0.29%; HR 0.37, 95% CI 0.15 to 0.95) No significant difference in disabling or fatal stroke (0.72% vs. 0.89%; HR 0.81, 95% CI 0.53 to 1.23) No significant difference in myocardial infarction (0.62% vs. 0.7%; HR 0.88, 95% CI 0.68 to 1.04) Safety outcomes No significant differences in serious complications of hypotension, including syncope. Conclusion In patients with recent lacunar stroke, lower BP target was not superior to higher BP target with respect to ischemic or hemorrhagic stroke. Reference SPS Study Group, Benavente OR, Coffey CS et al. Blood-pressure targets in patients with recent lacunar stroke: the SPS3 randomised trial. Lancet. 2013 Aug 10;382(9891):507-15. Open reference URL https://web.pathway.md/studies/recI8N4lPXRnJlAkq 2/2