What scenarios increase the risk of bleeding when taking prophylactic aspirin?
A nonexhaustive list of scenarios associated with increased risk of bleeding when taking prophylactic aspirin includes a history of previous gastrointestinal bleeding or peptic ulcer disease or bleeding from other sites, age >70 years, thrombocytopenia, coagulopathy, CKD, and concurrent use of other medications that increase bleeding risk, such as nonsteroidal anti-inflammatory drugs, steroids, direct oral anticoagulants, and warfarin.