What is the recommended regimen for enterococcal IE?
Regimens recommended for enterococcal IE are shown in Tables 12 through 15. Enterococci should be routinely tested in vitro for susceptibility to penicillin or ampicillin and vancomycin (MIC determination) and for high-level resistance to gentamicin to predict synergistic interactions. Killing of susceptible strains of enterococci requires the synergistic action of penicillin, ampicillin, or vancomycin in combination with either gentamicin or streptomycin. Generally, gentamicin should be administered for the initial 2 weeks of therapy with either -lactam or vancomycin- containing regimens (Class I; Level of Evidence C).