What are the effects of metformin on cardiovascular outcomes in patients with type 2 diabetes and coronary artery disease?
A meta-analysis of studies showed that metformin was associated with a reduced risk of all-cause mortality, cardiovascular mortality, myocardial infarction, and stroke compared to other anti-diabetic agents in patients with type 2 diabetes and coronary artery disease. Moreover, metformin was associated with a reduction in total cholesterol, LDL cholesterol, and triglyceride levels compared to other agents. (Hong et al., 2013)