What is the effect of B-vitamins on stroke risk among individuals with vascular disease who are not on antiplatelets?
A meta-analysis conducted by Park JH et al. found that B-vitamins may reduce the risk of stroke among individuals with vascular disease who are not on antiplatelets. Studies have found that folic acid supplementation, as well as homocysteine-lowering interventions based on folic acid, can be effective in reducing the risk of stroke. Additionally, methylenetetrahydrofolate reductase C677T polymorphism was found to have a modifying effect on the risk of stroke when combined with folic acid intervention. However, further studies are needed to solidify these findings.  