What is the recommendation for the use of factor Xa inhibitors in the treatment of AIS?
The safety and usefulness of oral factor Xa inhibitors in the treatment of AIS are not well established. IIb C-LD New recommendation. Limited data exist on the use of factor Xa inhibitors (eg, rivaroxaban, apixaban, edoxaban) for treatment of patients with AIS.227 Several prospective observational studies and early-phase trials are ongoing (NCT02279940, NCT02042534, NCT02283294). Further clinical trials are needed. See Table LI in online Data Supplement 1.