what are the Recommendations for Management of Excessive Anticoagulation
and Serious Bleeding in Patients With Prosthetic Valves
Referenced studies that support the recommendations are
summarized in Online Data Supplement 37.?
For patients with mechanical valves and uncontrollable bleeding who have received 4-factor prothrombin concentrate complex, adjunctive use of intravenous vitamin K is reasonable if resumption of VKA therapy is not anticipated for 7 days.