what are the Recommendations for Medical Therapy of Chronic AR
Referenced studies that support the recommendations are
summarized in Online Data Supplement 14.?
In patients with severe AR who have symptoms and/or LV systolic dysfunction (Stages C2 and D) but a prohibitive surgical risk, GDMT for reduced LVEF with ACE inhibitors, ARBs, and/or sacubitril/valsartan is recommended.