What are the results of the RCTs examining the effects of intensive versus less-intensive BP control on mortality in patients with CKD without diabetes?
Over a mean follow-up of 3.23 years of the 9351 participants in these 5 studies, 84 deaths per 1000 participants were seen in the standard BP control arm, and 66 per 1000 participants in the intensive BP control arm (18 fewer deaths per 1000; 95% CI: 26 fewer 8 fewer deaths per 1000 participants). Secondary analyses of the MDRD and AASK cohorts using administrative databases have also suggested long-term survival benefits from a lower MAP target.