6/29/23, 1:42 AM PREOXYFLOW Pathway Feedback Search Clinical Topics Home Studies PREOXYFLOW PREOXYFLOW Trial question What is the role of high-flow therapy by nasal cannula for preoxygenation in patients with acute hypoxemia? Study design Multi-center Open label RCT Population Characteristics of study participants 34.0% female N = 119 66.0% male 119 patients (41 female, 78 male) Inclusion criteria: adult patients with acute hypoxemia requiring intubation Key exclusion criteria: contraindication to orotracheal intubation; intubation without anesthetic rapid sequence induction; intubation for cardiac arrest; asphyxia requiring immediate intubation; nasopharyngeal obstacle; Grade 4 glottis exposure on the Cormack-Lehane scale Interventions N=62 high-flow nasal cannula (for preoxygenation before intubation) N=57 high fraction-inspired oxygen facial mask Primary outcome Oxygen saturation at its lowest during intubation procedure 91.5 % 91.5 89.5 68.6 % 45.8 % 22.9 % https://web.pathway.md/studies/rec73A27tcs9Vjako 1/2 6/29/23, 1:42 AM PREOXYFLOW Pathway No significant difference 0.0 % High-flow nasal cannula High fraction-inspired oxygen facial mask No significant difference in oxygen saturation at its lowest during the intubation procedure (91.5% vs. 89.5%; AD 2%, 95% CI -2.99 to 6.99) Secondary outcomes No significant difference in ventilator-free days (14 days vs. 5 days; AD 9 days, 95% CI -1.41 to 19.41) No significant difference in difficult intubation (1.6% vs. 7.1%; ARD -5.5, 95% CI -13.52 to 2.52) No significant difference in death at day 28 (35.4% vs. 42.1%; ARD -6.7, 95% CI -24.9 to 11.5) Safety outcomes No significant differences in ventilator-associated pneumonia, intubation-related adverse events including desaturation. Conclusion In adult patients with acute hypoxemia requiring intubation, high-flow nasal cannula was not superior to high fraction-inspired oxygen facial mask with respect to oxygen saturation at its lowest during the intubation procedure. Reference Micka l Vourc'h, Pierre Asfar, Christelle Volteau et al. High-flow nasal cannula oxygen during endotracheal intubation in hypoxemic patients: a randomized controlled clinical trial. Intensive Care Med. 2015 Sep;41(9):1538-48. Open reference URL https://web.pathway.md/studies/rec73A27tcs9Vjako 2/2