What are the benefits of SGLT2 inhibitors for HFrEF care?
The benefits of SGLT2 inhibitors for HFrEF care include osmotic diuresis and natriuresis, decreases in arterial pressure and stiffness, and a shift to ketone-based myocardial metabolism. These benefits may lead to a reduced risk for major events such as hospitalization or death, as well as a reduction of preload and afterload blunting of cardiac stress/injury with less hypertrophy and fibrosis, which would have favorable effects on myocardial remodeling. 