6/28/23, 1:20 AM Dexmedetomidine in DCD kidney transplant Pathway Feedback Search Clinical Topics Home Studies Dexmedetomidine in DCD kidney transplant Dexmedetomidine in DCD kidney transplant Trial question What is the role of dexmedetomidine in patients scheduled for a donation-after-cardiac-death kidney transplant? Study design Single center Double blinded RCT Population Characteristics of study participants 42.0% female N = 111 58.0% male 111 patients (47 female, 64 male) Inclusion criteria: adult patients scheduled for a donation-after-cardiac death kidney transplant Key exclusion criteria: sick sinus syndrome; AV block; LVEF < 30%; multiorgan transplant Interventions N=56 dexmedetomidine (24-hour perioperative intravenous infusion of 0.4 g/kg/hour intraoperatively and 0.1 g/kg/hour postoperatively) N=55 placebo (24-hour normal saline infusion with matching infusion rates) Primary outcome Rate of need for dialysis in the first posttransplant week 34.5 % 34.5 25.9 % 17.9 17.3 % Significant decrease 8.6 % https://web.pathway.md/studies/recRYpbmiLm1m83c8 1/2 6/28/23, 1:20 AM Dexmedetomidine in DCD kidney transplant Pathway NNT = 6 0.0 % Dexmedetomidine Placebo Significant decrease in the rate of need for dialysis in the first posttransplant week (17.9% vs. 34.5%; OR 0.41, 95% CI 0.17 to 0.98) Secondary outcomes Significant decrease in repeated dialysis in the hospital (12.5% vs. 30.9%; OR 0.32, 95% CI 0.13 to 0.88) No significant difference in mean serum creatinine level at 30 day posttransplant (1.42 mg/dL vs. 1.57 mg/dL; MD -0.15, 95% CI -0.6 to 0.29) No significant difference in mean eGFR at 30 day posttransplant (65.1 mL/min/1.73 m vs. 63.3 mL/min/1.73 m ; MD 1.82, 95% CI -7.89 to 11.52) Conclusion In adult patients scheduled for a donation-after-cardiac death kidney transplant, dexmedetomidine was superior to placebo with respect to the rate of need for dialysis in the first posttransplant week. Reference Xi-Sheng Shan, Lin-Kun Hu, Yiqing Wang et al. Effect of Perioperative Dexmedetomidine on Delayed Graft Function Following a Donation-After-Cardiac-Death Kidney Transplant: A Randomized Clinical Trial. JAMA Netw Open. 2022 Jun 1;5(6):e2215217. Open reference URL https://web.pathway.md/studies/recRYpbmiLm1m83c8 2/2