What is the relationship between the beta adrenoceptor polymorphism and sudden death?
Studies have found that certain polymorphisms of the beta-adrenergic receptor may be associated with an increased risk of sudden death. The Arg389Gly polymorphism has been associated with a higher risk of mortality in patients with heart failure, while the Gly389Arg polymorphism has been linked to a higher risk of cardiovascular response to metoprolol. Additionally, the CAREGENE study found that polymorphisms of the beta-adrenergic receptor gene may be associated with the aerobic power of coronary artery disease patients.