What is the role of Lipoprotein(a) in the evolution of advanced carotid plaques?
Lipoprotein(a) has been associated with carotid stenosis, occlusion, and total plaque area. Studies such as the Bruneck Study, have found evidence of a prominent role of Lipoprotein(a) in the evolution of advanced carotid plaques. Lipoprotein(a) has also been found to be higher in atherothrombotic than lacunar ischemic cerebrovascular diseases, and a meta-analysis of observational studies has also suggested that Lipoprotein(a) may play a role in stroke risk. Overall, Lipoprotein(a) appears to be an important predictor of cardiovascular disease.