What is the safety of protocol violations in acute stroke tPA administration?
A study conducted by Rawal et al. (437) found that there was no significant difference in safety outcomes between patients who received thrombolytic therapy with tissue plasminogen activator (tPA) in accordance with protocol guidelines versus those who received tPA with protocol violations. However, the study found that the protocol violations were associated with a slightly increased risk of symptomatic intracranial hemorrhage. Therefore, it is important to ensure that protocol guidelines are followed when administering tPA to stroke patients to minimize the risk of complications.