What is Ciraparantag?
Ciraparantag is a small synthetic water-soluble molecule developed as a reversal agent for unfractionated heparin (UFH), LMWHs, fondaparinux, and the oral direct Xa and IIa inhibitors. It binds to targets through noncovalent hydrogen bonding and charge-charge interactions thereby preventing the anticoagulants from binding to their endogenous targets.