What are the effects of combining aldosterone antagonists with ACE-Is, ARBs, or other potassium-sparing diuretics?
Great care should be exercised when aldosterone antagonists are combined with ACE-Is, ARBs, or other potassium-sparing diuretics. There is little information regarding the combination of aldosterone antagonists with NSAIDs or COX-2 inhibitors, but as with ACE-Is and ARBs, caution is warranted. Combining aldosterone antagonists with ACE-Is, ARBs, or other potassium-sparing diuretics may increase the risk of hyperkalemia.