What is the impact of renal function on the effects of LDL cholesterol lowering with statins?
The Cholesterol Treatment Trialists' Collaboration conducted a meta-analysis of individual participant data from 28 randomized trials to assess the impact of renal function on the effects of LDL cholesterol lowering with statin-based regimens. The results showed that LDL cholesterol lowering with statins was associated with a reduction in major vascular events in all renal function categories, including those with chronic kidney disease (CKD). The magnitude of effect was similar across renal function categories, indicating that statin therapy is effective for all individuals regardless of renal function.