6/28/23, 11:22 PM NICE-SUGAR Pathway Feedback Search Clinical Topics Home Studies NICE SUGAR NICE SUGAR Disease In-hospital hyperglycemia Trial question What is the role of intensive glucose control in critically ill patients? Study design Multi-center Open label RCT Population Characteristics of study participants 36.4% female N = 6104 63.6% male 6104 patients (2207 female, 3823 male) Inclusion criteria: adult medical and surgical patients admitted to the ICU who were expected to require treatment in the ICU on 3 consecutive days Key exclusion criteria: age < 18 years, imminent death (cardiac standstill or brain death anticipated within 24 hours), ICU admission for treatment of diabetic ketoacidosis or hyperosmolar state, previous hypoglycemia without full neurological recovery, or at high risk of hypoglycemia Interventions N=3054 intensive glucose control (with a target blood glucose range of 81-108 mg/dL) N=3050 conventional glucose control (with a target of 180 mg/dL) Primary outcome https://web.pathway.md/studies/recMRdVfWm69jC8Xx 1/2 6/28/23, 11:22 PM NICE-SUGAR Pathway Death from all causes at day 90 27.5 % 27.5 24.9 20.6 % 13.8 % Significant increase 6.9 % NNH = 38 0.0 % Intensive glucose control Conventional glucose control Significant increase in death from all causes at day 90 (27.5% vs. 24.9%; OR 1.14, 95% CI 1.02 to 1.28) Secondary outcomes No significant difference in RRT (15.4% vs. 14.5%; AD 0.9%, 95% CI -9 to 2.7) No significant difference in death at day 28 (22.3% vs. 20.8%; OR 1.09, 95% CI 0.96 to 1.23) Safety outcomes Significant difference in severe hypoglycemia (6.8% vs. 0.5%). Conclusion In adult medical and surgical patients admitted to the ICU who were expected to require treatment in the ICU on 3 consecutive days, intensive glucose control was inferior to conventional glucose control with respect to death from all causes at day 90. Reference NICE-SUGAR Study Investigators, Finfer S, Chittock DR et al. Intensive versus conventional glucose control in critically ill patients. N Engl J Med. 2009 Mar 26;360(13):1283-97. Open reference URL https://web.pathway.md/studies/recMRdVfWm69jC8Xx 2/2