What are the effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy?
The effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy were studied in the study by Brenner et al. (2001). The study found that losartan was associated with a significant reduction in the risk of end-stage renal disease, doubling of creatinine, progression of diabetic nephropathy, and cardiovascular risk. Additionally, losartan was found to be associated with an improvement in proteinuria and a reduction in the risk of stroke and death from any cause.