What is the recommended treatment for enterococcal endocarditis on native cardiac valves or prosthetic material?
Enterococcal endocarditis is relatively rare in children. Treatment consists of a combination of penicillin, ampicillin, or ceftriaxone with gentamicin for 6 weeks (Class I; Level of Evidence C).  For patients unable to tolerate -lactam therapy, vancomycin for 6 weeks is combined with gentamicin for the first 2 weeks of therapy. In -lactam intolerant patients with Abiotrophia infections, therapy consists of a combination of vancomycin and gentamicin for 6 weeks.