What are the relative values of different outcomes considered by the committee for the review?
The committee considered the following outcomes to be critical for this review: all-cause mortality (over study duration), all-cause mortality (at 30 days), quality of life, and all-cause hospitalisation. Data on all-cause mortality and hospitalisation were considered preferable to data limited to heart failure-related mortality and hospitalisations, as such data take into account the broader unintended consequences of the interventions (for example, an increase in mortality or hospitalisations due to adverse events or surgical complications). Improvement in ejection fraction and NYHA class, as well as additional revascularisation events and stroke, were also considered to be important for decision-making.