What is the role of factor XI and factor XII in thrombosis?
Factor XI and Factor XII play a critical role in thrombosis. Strategies to target these factors include antisense oligonucleotides that reduce hepatic synthesis of the clotting proteins, monoclonal antibodies that block activation or activity, aptamers, small molecules that block the active site or induce allosteric modulation, and polyanion antagonists that attenuate contact activation by nullifying stimulators of the pathway. Human data is limited, however, a factor XI-directed antisense oligonucleotide called IONIS-416858 has been compared with enoxaparin in 300 patients undergoing elective knee arthroplasty.