6/29/23, 11:57 PM Sub-Threshold Exercise for SRC Pathway Feedback Search Clinical Topics Home Studies Sub-Threshold Exercise for SRC Sub-Threshold Exercise for SRC Disease Concussion Trial question What is the effect of early subsymptom threshold aerobic exercise treatment in adolescents with sport-related concussion? Study design Multi-center Open label RCT Population Characteristics of study participants 47.0% female N = 103 53.0% male 103 patients (48 female, 55 male) Inclusion criteria: adolescent athletes, aged 13-18 years, presenting within 10 days of sport- related concussion Key exclusion criteria: evidence of focal neurological deficit; inability to exercise because of orthopedic injury, cervical spine injury, diabetes, or known heart disease; increased cardiac risk according to american college of sports medicine criteria; history of moderate-severe TBI Interventions N=52 aerobic exercise (prescription to exercise at 80% of their threshold HR for symptom exacerbation) N=51 stretching exercise (prescription for daily stretching lasting approximately 20 minutes) https://web.pathway.md/studies/recavRQSVi3rPjaQ5 1/2 6/29/23, 11:57 PM Sub-Threshold Exercise for SRC Pathway Primary outcome Median recovery time 17.0 days 17 13 12.8 days 8.5 days 4.3 days Significant decrease 0.0 days Aerobic exercise Stretching exercise Significant decrease in median recovery time (13 days vs. 17 days; AD -4 days, 95% CI -7 to -1) Secondary outcomes No significant difference in delayed recovery since injury (4% vs. 14%; ARD -10, 95% CI -21.21 to 1.21) No significant difference in daily symptom reporting (83.8% vs. 86.6%; RR 0.97, 95% CI -0.38 to 2.32) Conclusion In adolescent athletes, aged 13-18 years, presenting within 10 days of sport-related concussion, aerobic exercise was superior to stretching exercise with respect to median recovery time. Reference John J Leddy, Mohammad N Haider, Michael J Ellis et al. Early Subthreshold Aerobic Exercise for Sport-Related Concussion: A Randomized Clinical Trial. JAMA Pediatr. 2019 Apr 1;173(4):319-325. Open reference URL https://web.pathway.md/studies/recavRQSVi3rPjaQ5 2/2