What is the significance of the overall ratings in GRADE?
The overall ratings in GRADE have a significance in that they are used to indicate the confidence in the estimate of effect. A High rating indicates that further research is very unlikely to change the confidence in the estimate of effect, while a Moderate rating indicates that further research is likely to have an important impact on the confidence in the estimate of effect. A Low rating indicates that further research is very likely to have an important impact on the confidence in the estimate of effect, and a Very Low rating indicates that any estimate of effect is very uncertain.