What is the effect of combining aldosterone antagonists with NSAIDs or COX-2 inhibitors?
There is little information available regarding the effect of combining aldosterone antagonists with NSAIDs or COX-2 inhibitors, but caution is advised as with ACE-Is and ARBs. Both spironolactone and eplerenone interact with cytochrome P-450, but definitive information regarding any effect on calcineurin inhibitors (CNIs) is not available. Caution is also advised when aldosterone antagonists are combined with other cytochrome P-450 metabolized agents such as verapamil.