What factors affect INR control?
Many factors affect INR control, including patient-related aspects (e.g., age, sex, socioeconomic status, diet, ethnicity, hospitalization, length of time on VKA, medical and psychiatric comorbidities, nonadherence, polypharmacy, genetic and health-care system-related factors, particularly how VKA is managed (by country, setting of OAC management, distance to OAC clinic, self-monitoring/self- frequency of INR monitoring, etc.), as well as dietary measures, time to achieve therapeutic range, and the SAMe-TT2R2 score. The SAMe-TT2R2 score awards 1 point for each of the following: sex (female); age <60 years; medical history (3 or more comorbidities); treatments (such as amiodarone); smoking status (double); and race (non-Caucasian, double).