6/29/23, 1:12 AM REVIVED-BCIS2 Pathway Feedback Search Clinical Topics Home Studies REVIVED BCIS2 REVIVED BCIS2 Disease Disease Coronary artery disease Heart failure Trial question What is the role of PCI in patients with severe ischemic LV systolic dysfunction? Study design Multi-center Open label RCT Population Characteristics of study participants 12.0% female N = 700 88.0% male 700 patients (86 female, 614 male) Inclusion criteria: patients with a LVEF 35%, extensive coronary artery disease amenable to PCI and demonstrable myocardial viability Key exclusion criteria: acute myocardial infarction in the 4 weeks before randomization; acute decompensated HF or sustained ventricular arrhythmias within 72 hours before randomization Interventions N=347 PCI (coronary angioplasty or stents plus optimal medical therapy) N=353 medical therapy alone (optimal medical therapy alone) Primary outcome Death from any cause or hospitalization for heart failure https://web.pathway.md/studies/rechxeS8GkVtapM9h 1/2 6/29/23, 1:12 AM REVIVED-BCIS2 Pathway 38.0 % 38 37.2 28.5 % 19.0 % 9.5 % No significant difference 0.0 % Percutaneous coronary intervention Medical therapy alone No significant difference in death from any cause or hospitalization for HF (37.2% vs. 38%; HR 0.99, 99% CI 0.78 to 1.27) Secondary outcomes No significant difference in improvement in LVEF at 6 months (1.8% vs. 3.4%; ARD -1.6, 95% CI -3.7 to 0.5) No significant difference in improvement in LVEF at 12 months (2% vs. 1.1%; AD 0.9%, 95% CI -1.7 to 3.4) No significant difference in death from cardiovascular causes (21.9% vs. 24.9%; HR 0.88, 95% CI 0.65 to 1.2) Safety outcomes No significant differences in serious adverse event, bleeding at 2 years. Significant difference in major bleeding at year 1 (3.1% vs. 0.6%). Conclusion In patients with a LVEF 35%, extensive coronary artery disease amenable to PCI and demonstrable myocardial viability, PCI was not superior to medical therapy alone with respect to death from any cause or hospitalization for HF. Reference Divaka Perera, Tim Clayton, Peter D O'Kane et al. Percutaneous Revascularization for Ischemic Left Ventricular Dysfunction. N Engl J Med. 2022 Oct 13;387(15):1351-1360. Open reference URL https://web.pathway.md/studies/rechxeS8GkVtapM9h 2/2