What is the key therapy among African Americans with HFrEF?
The key therapy among African Americans with HFrEF is HYD/ISDN (hydralazine/isosorbide dinitrate). This is a combination of two vasodilators – hydralazine and isosorbide dinitrate – which have been found to improve symptoms and reduce mortality in African Americans with HFrEF. ARNIs, ACEIs, and ARBs are also recommended as part of GDMT (Guideline-Directed Medical Therapy), though there is a potential risk of angioedema in African Americans compared to Caucasian patients. Additionally, when combining new drugs with HYD/ISDN, there is an uncertain risk of hypotension.