How does the association of systolic blood pressure with mortality vary with left ventricular systolic dysfunction severity?
In patients with HF with mild to moderate LV systolic dysfunction, SBP was found to have a nonlinear U-shaped association with increased all-cause mortality at both the lower and upper ranges of SBP (Figure 3A). In patients with HF with severe LV systolic dysfunction, SBP was found to have a linear association, with lower SBP being associated with worse mortality (Figure 3B). These results suggest that the association of SBP with mortality may vary with LV function severity.