what are the Recommendations for Anticoagulation for Pregnant Women With
Mechanical Prosthetic Heart Valves
Referenced studies that support the recommendations are
summarized in Online Data Supplement 44.?
For pregnant women with mechanical prostheses who require a dose of warfarin >5 mg/d to achieve a therapeutic INR, and for whom dose-adjusted LMWH is unavailable, dose-adjusted continuous intravenous UFH during the first trimester (with aPTT 2 times control), followed by warfarin for the second and third trimesters, is reasonable.