What drugs should be avoided in patients with heart failure?
Several classes of drugs should be avoided in patients with HFrEF with a history of hypertension, such as renin inhibition with aliskiren and catheter-based renal artery denervation (SYMPLICITY HTN-3 trial [A Controlled Trial of Renal Denervation for Resistant Hypertension]). Other strategies such as targeting excessive sympathetic nerve activity by carotid body denervation are awaiting clinical validation in the hypertension and HF populations.