What methods are used to grade the quality of evidence and the strength of a guideline recommendation?
A structured approach, based on GRADE108 110 and facilitated by the use of evidence profiles, is used to grade the quality of the overall evidence and the strength of recommendations. For each topic, the discussion on grading of the quality of the evidence is led by the ERT, and the discussion regarding the strength of the recommendations is led by the Work Group Co-Chairs. The strength of a recommendation indicates the extent to which one can be confident that adherence to the recommendation will do more good than harm.