6/28/23, 11:16 PM MASS Pathway Feedback Search Clinical Topics Home Studies MASS MASS Disease Abdominal aortic aneurysm Trial question What is the role of screening men for AAA? Study design Multi-center Open label RCT Population 67770 male patients Inclusion criteria: men aged 65-74 years Key exclusion criteria: females, age < 65 and > 74 years, terminally ill men, other serious health problems, and previous AAA repair Interventions N=33883 ultrasound screening for AAA (invitation to screening program) N=33887 no ultrasound screening (not routinely offered screening) Primary outcome Death related to abdominal aortic aneurysm at 10 years 0.9 % 0.87 0.7 % 0.46 0.4 % 0.2 % Borderline significant decrease 0.0 % https://web.pathway.md/studies/recnjzl37afj4s48r 1/2 6/28/23, 11:16 PM MASS Pathway Ultrasound screening for abdominal aortic aneurysm No ultrasound screening Borderline significant decrease in death related to AAA at 10 years (0.46% vs. 0.87%; HR 0.52, 95% CI 0.43 to 0.63) Secondary outcomes No significant difference in death at 30 days (4% vs. 6%; RR 0.67, 95% CI -0.42 to 1.76) Conclusion In men aged 65-74 years, ultrasound screening for AAA was superior to no ultrasound screening with respect to death related to AAA at 10 years. Reference Thompson SG, Ashton HA, Gao L et al. Screening men for abdominal aortic aneurysm: 10 year mortality and cost effectiveness results from the randomised Multicentre Aneurysm Screening Study. BMJ. 2009 Jun 24;338:b2307. Open reference URL https://web.pathway.md/studies/recnjzl37afj4s48r 2/2