What were the results of the Carvedilol Or Metoprolol European Trial (COMET)?
The Carvedilol Or Metoprolol European Trial (COMET) was a randomised controlled trial that compared the effects of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure. The results of the trial showed that carvedilol was more effective than metoprolol in reducing mortality and hospitalization due to heart failure. Additionally, carvedilol was found to improve quality of life measures such as physical performance, exercise tolerance, and symptoms of heart failure. 