what are the Recommendations for Selecting an Anticoagulant Regimen—
Balancing Risks and Benefits
Referenced studies that support new or modified recommendations
are summarized in Online Data Supplements 1 and 2.?
NOACs (dabigatran, rivaroxaban, apixaban, and edoxaban) are recommended over warfarin in NOAC-eligible patients with AF (except with moderate-to-severe mitral stenosis or a mechanical heart valve).S4.1.1-8?S4.1.1-11 NEW: Exclusion criteria are now defined as moderate-to-severe mitral stenosis or a mechanical heart valve. When the NOAC trials are considered as a group, the direct thrombin inhibitor and factor Xa inhibitors were at least noninferior and, in some trials, superior to warfarin for preventing stroke and systemic embolism and were associated with lower risks of serious bleeding.