6/27/23, 11:46 PM BP-TARGET Pathway Feedback Search Clinical Topics Home Studies BP TARGET BP TARGET Disease Acute ischemic stroke Trial question What is the role of intensive systolic BP target after successful endovascular therapy in acute ischemic stroke? Study design Multi-center Open label RCT Population Characteristics of study participants 52.0% female N = 318 48.0% male 318 patients (165 female, 153 male) Inclusion criteria: adults with an acute ischemic stroke due to a large-vessel occlusion that was successfully treated with endovascular therapy Key exclusion criteria: per-procedure hemorrhagic complications; systolic BP at baseline < 130 mm Hg within 1 hour of recanalization; pre-existing stroke disability defined by a mRS score > 2 Interventions N=158 intensive systolic BP target (systolic BP target of 100-129 mm Hg) N=160 standard systolic BP target (systolic BP target of 130-185 mm Hg) Primary outcome Radiographic intraparenchymal hemorrhage at 24-36 hours 43 43.0 % 42 https://web.pathway.md/studies/recshUsqEfTr8oaWf 1/2 6/27/23, 11:46 PM BP-TARGET Pathway 32.3 % 21.5 % 10.8 % No significant difference 0.0 % Intensive systolic blood pressure target Standard systolic blood pressure target No significant difference in radiographic intraparenchymal hemorrhage at 24-36 hours (42% vs. 43%; OR 0.96, 96% CI 0.6 to 1.51) Secondary outcomes No significant difference in favorable outcome at 3 months (44% vs. 45%; OR 0.93, 95% CI 0.58 to 1.48) No significant difference in excellent outcome at 3 months (32% vs. 28%; OR 1.2, 95% CI 0.72 to 1.97) No significant difference in reduction in NIHSS score at 24-36 hours (4.1 vs. 4.4; AD -0.3, 95% CI -1.7 to 2.3) Safety outcomes No significant differences in death from all causes, parenchymal hematoma type 2 at 24-36 hours. Significant difference in hypotension (8% vs. 3%). Conclusion In adults with an acute ischemic stroke due to a large-vessel occlusion that was successfully treated with endovascular therapy, intensive systolic BP target was not superior to standard systolic BP target with respect to radiographic intraparenchymal hemorrhage at 24-36 hours. Reference Mikael Mazighi, Sebastien Richard, Bertrand Lapergue et al. Safety and efficacy of intensive blood pressure lowering after successful endovascular therapy in acute ischaemic stroke (BP- TARGET): a multicentre, open-label, randomised controlled trial. Lancet Neurol. 2021 Apr;20(4):265-274. Open reference URL https://web.pathway.md/studies/recshUsqEfTr8oaWf 2/2