What antibiotics should be used to treat PVE caused by oxacillin-susceptible CoNS?
Nafcillin or oxacillin plus rifampin in combination with gentamicin for the first 2 weeks of therapy should be used to treat PVE caused by oxacillin-susceptible CoNS. A first-generation cephalosporin or vancomycin may be substituted for nafcillin/oxacillin for patients who are truly allergic to penicillin.