6/28/23, 10:58 PM LDPEEPPC Pathway Feedback Search Clinical Topics Home Studies LDPEEPPC LDPEEPPC Disease Disease Disease Bronchiectasis Non-small cell lung cancer Small cell Trial question What is the effect of PEEP titration to the lowest driving pressure in patients undergoing selective lung resection surgery? Study design Single center Double blinded RCT Population Characteristics of study participants 47.0% female N = 207 53.0% male 207 patients (98 female, 109 male) Inclusion criteria: patients undergoing selective lung resection surgery Key exclusion criteria: age < 18 years; pregnancy Interventions N=104 PEEP titration to the lowest driving pressure (PEEP titration to the lowest driving pressure during one-lung ventilation) N=103 conventional low level of PEEP (PEEP level of 4 cmH O during one-lung ventilation) Primary outcome Rate of development of 4 Melbourne Group Scale variables within 3 postoperative days https://web.pathway.md/studies/recYybS0wOBUHRg6x 1/2 6/28/23, 10:58 PM LDPEEPPC Pathway 13.0 % 13 9.8 % 6.5 % 4 Significant decrease 3.3 % NNT = 11 0.0 % Positive end-expiratory pressure titration to the lowest driving pressure Conventional low level of positive end-expiratory pressure Significant decrease in the rate of development of 4 Melbourne Group Scale variables within 3 postoperative days (4% vs. 13%; RR 0.32, 95% CI 0.1 to 0.9) Secondary outcomes No significant difference in the rate of major postoperative pulmonary complications within 7 postoperative days (96% vs. 96%; RR 1, 95% CI 0.95 to 1.06) No significant difference in CXR atelectasis or infiltration (79% vs. 75%; RR 1.06, 95% CI 0.91 to 1.23) Conclusion In patients undergoing selective lung resection surgery, PEEP titration to the lowest driving pressure was superior to conventional low level of PEEP with respect to the rate of development of 4 Melbourne Group Scale variables within 3 postoperative days. Reference Junjie Yu, Zhijie Wu, Rui An et al. Association between driving pressure and postoperative pulmonary complications in patients undergoing lung resection surgery: A randomised clinical trial. Anaesth Crit Care Pain Med. 2022 Sep 19;42(1):101160. Open reference URL https://web.pathway.md/studies/recYybS0wOBUHRg6x 2/2