6/28/23, 11:01 PM Leuven Surgical Trial Pathway Feedback Search Clinical Topics Home Studies Leuven Surgical Trial Leuven Surgical Trial Disease Disease Diabetes mellitus type 2 In-hospital hyperglycemia Trial question Is intensive insulin therapy superior to conventional treatment in critically ill patients? Study design Single center Double blinded RCT Population Characteristics of study participants 29.0% female N = 1548 71.0% male 1548 patients (447 female, 1101 male) Inclusion criteria: adults admitted to surgical ICU who were receiving mechanical ventilation Key exclusion criteria: participation in other trials, moribund state, or for whom there were do-not- resuscitate orders Interventions N=765 intensive insulin therapy (maintenance of blood glucose at a level between 80 and 110 mg/dL) N=783 conventional treatment (infusion of insulin only if the blood glucose level exceeded 215 mg/dL and maintenance of glucose at a level between 180 and 200 mg/dL) Primary outcome https://web.pathway.md/studies/recFOFPNotDDh5RzM 1/2 6/28/23, 11:01 PM Leuven Surgical Trial Pathway Death 8.0 % 8 6.0 % 4.6 4.0 % Significant decrease 2.0 % NNT = 29 0.0 % Intensive insulin therapy Conventional treatment Significant decrease in death (4.6% vs. 8%; RR 0.58, 95% CI 0.38 to 0.78) Secondary outcomes Significant decrease in the rate of death, among patients who remained in the ICU for > 5 days (10.6% vs. 20.2%; RR 0.52, 95% CI 0.16 to 0.88) Conclusion In adults admitted to surgical ICU who were receiving mechanical ventilation, intensive insulin therapy was superior to conventional treatment with respect to death. Reference van den Berghe G, Wouters P, Weekers F et al. Intensive insulin therapy in critically ill patients. N Engl J Med. 2001 Nov 8;345(19):1359-67. Open reference URL https://web.pathway.md/studies/recFOFPNotDDh5RzM 2/2