What is the risk of ICH with DAPT?
Meta-analyses report that those using DAPT with aspirin and clopidogrel for long-term use have a significantly increased risk of ICH and major bleeding. The exact duration of DAPT at which the risk of hemorrhage begins to outweigh the benefit of stroke prevention is unknown, but meta-analyses report as early as 21,802 or and those with more appear to be at higher risk of ICH with DAPT.