What trials have been conducted to study the effect of IV iron on HF pathophysiology?
The IRONMAN trial (https://clinicaltrials.gov/ct2/show/NCT02642562), funded by the British Heart Foundation, is an active trial that will look at longer time points to study the effect of IV iron on HF pathophysiology. It should also provide long term data on clinical effectiveness. The trials conducted so far have only included people with reduced ejection fraction, and it has not been possible to generalise the evidence in these trials to people with HFPEF.