What is the outcome of UPSTEP trial regarding Natriuretic Peptides monitoring?
The UPSTEP trial found that Natriuretic Peptides monitoring compared to clinical monitoring increased therapy towards guideline-target doses to reach BNP and improved outcomes such as all-cause admission, mortality, and HF hospitalization in patients aged <75 years and >300 ng/L for those aged >75 years, despite standard treatment with ACEi/ARB and BB.