What are the recommended antibiotics for use as prophylaxis during CIED implantation?
Most experts continue to advocate a first-generation cephalosporin, such as cefazolin, for use as prophylaxis. Although not generally recommended, some advocate the use of vancomycin instead of cefazolin, particularly in centers where oxacillin resistance among staphylococci is high. If vancomycin is used, then it should be administered 90 to 120 minutes before the procedure. Vancomycin also represents an alternative to a first-generation cephalosporin in patients who are allergic to cephalosporins. In patients who are allergic to both cephalosporins and vancomycin, daptomycin and linezolid represent prophylaxis options.