What is the recommendation for use of IV alteplase for adults presenting with an AIS with known sickle cell disease?
The recommendation for use of IV alteplase for adults presenting with an AIS with known sickle cell disease is IIa B-NR, which is a new recommendation. A case-control analysis using the population from the AHA GWTG-Stroke registry, including 832 cases with sickle cell disease (all adults) and 3328 age-, sex-, and race-matched controls without sickle cell disease with similar severity of neurological deficits at presentation, showed that sickle cell disease did not have a significant impact on the safety or the outcome at discharge of treatment with IV alteplase.