6/29/23, 1:34 AM PAC-Man Pathway Feedback Search Clinical Topics Home Studies PAC Man PAC Man Trial question What is the role of pulmonary artery catheters in the management of critically ill patients? Study design Multi-center Open label RCT Population Characteristics of study participants 42.0% female N = 1014 58.0% male 1014 patients (423 female, 591 male) Inclusion criteria: adult patients admitted to an ICU Key exclusion criteria: age < 16 years; elective admission for preoperative optimization; presence of a pulmonary artery catheter on admission to intensive care; previous enrolment to the study; or hemodynamic optimization before organ donation Interventions N=519 pulmonary artery catheter (catheter placed as soon as possible after randomization, according to local practice) N=522 control (management without pulmonary artery catheter) Primary outcome Death in hospital 68.0 % 68 66 51.0 % 34.0 % 17.0 % https://web.pathway.md/studies/rechfIzKcL7f1Ewqr 1/2 6/29/23, 1:34 AM PAC-Man Pathway No significant difference 0.0 % Pulmonary artery catheter Control No significant difference in death in the hospital (68% vs. 66%; HR 1.07, 95% CI 0.92 to 1.24) Secondary outcomes No significant difference in median ICU length of stay among survivors (12.1 days vs. 11 days; AD 1.1 days, 95% CI -0.8 to 3) No significant difference in median hospital length of stay among survivors (34 days vs. 40 days; AD -6 days, 95% CI -20.65 to 8.65) Safety outcomes No significant differences in death at 28 days, death in the ICU. Conclusion In adult patients admitted to an ICU, pulmonary artery catheter was not superior to control with respect to death in the hospital. Reference Sheila Harvey, David A Harrison, Mervyn Singer et al. Assessment of the clinical effectiveness of pulmonary artery catheters in management of patients in intensive care (PAC-Man): a randomised controlled trial. Lancet. 2005 Aug 6-12;366(9484):472-7. Open reference URL https://web.pathway.md/studies/rechfIzKcL7f1Ewqr 2/2