What is the GRADE approach?
The GRADE approach is a method used to assess the quality of the evidence for each outcome. For outcomes that are based on data from RCTs, the initial grade for the quality of the evidence is considered to be high. For observational studies, the initial quality of the evidence is low. This approach takes into account factors such as the risk of bias, the source of funding (industry vs. other), language of publication, and country in which the study was conducted. It is used to grade the quality of the evidence and the strength of a guideline recommendation.