What is the association between oophorectomy and risk of total stroke?
The findings from 3 of the studies not yet discussed previously suggest that women who underwent an oophorectomy before age 50 years had an increased risk of total stroke (HR, 1.47; 95% CI, 1.16 1.87) compared with women with no hysterectomy and no oophorectomy. In a recent analysis of the Women's Health Initiative, no association was found for oophorectomy versus ovarian conservation and risk of total stroke in all women (HR, 1.04; 95% CI, 0.87 1.24) or those women without a history of hormone use (HR, 1.31; 95% CI, 0.92 1.87) after multivariable adjustment. 