What are the recommendations for managing clinically significant drug-drug interactions with statins and select agents used in patients with cardiovascular disease?
The American Heart Association Clinical Pharmacology Committee of the Council on Clinical Cardiology, Council on Hypertension, Council on Quality of Care and Outcomes Research, and Council on Functional Genomics and Translational Biology have provided recommendations for managing clinically significant drug-drug interactions with statins and select agents used in patients with cardiovascular disease. The recommendations include avoiding concomitant use of certain medications, monitoring for potential drug-drug interactions, and adjusting the dose of the statin or the other drug as needed.