6/29/23, 11:57 PM SUPPORT Pathway Feedback Search Clinical Topics Home Studies SUPPORT SUPPORT Trial question What is the role of right heart catheterization in the initial care of critically ill patients? Study design Multi-center Open label Observational study Population Characteristics of study participants 44.0% female N = 5735 56.0% male 5735 patients (2543 female, 3192 male) Inclusion criteria: critically ill adult patients receiving care in an ICU Key exclusion criteria: age < 18 years; death or discharge in < 48 hours; acute psychiatric disorders; pregnancy; AIDS; acute burns; head trauma Interventions N=2184 right heart catheterization (performed within 24 hours of study entry) N=3551 no right heart catheterization (standard of care without right heart catheterization) Primary outcome Survival at day 30 69.4 % 69.4 62 52.1 % 34.7 % Significant decrease 17.4 % NNH = 14 0.0 % https://web.pathway.md/studies/recW6YY9FYnTRUkXt 1/2 6/29/23, 11:57 PM SUPPORT Pathway Right heart catheterization No right heart catheterization Significant decrease in survival at day 30 (62% vs. 69.4%; ARD -7.4, 95% CI -11.79 to -3.01) Secondary outcomes Significant decrease in survival at 2 months (54.5% vs. 62.8%; ARD -8.3, 95% CI -13.22 to -3.38) Significant decrease in survival at 6 months (46.3% vs. 53.7%; ARD -7.4, 95% CI -11.79 to -3.01) Significant increase in length of stay in the ICU (15.5 days vs. 10.3 days; AD 5.2 days, 95% CI 2.11 to 8.29) Conclusion In critically ill adult patients receiving care in an ICU, right heart catheterization was inferior to no right heart catheterization with respect to survival at day 30. Reference A F Connors Jr, T Speroff, N V Dawson et al. The effectiveness of right heart catheterization in the initial care of critically ill patients. SUPPORT Investigators. JAMA. 1996 Sep 18;276(11):889-97. Open reference URL https://web.pathway.md/studies/recW6YY9FYnTRUkXt 2/2