What is the Kronos Early Estrogen Prevention Study (KEEPS) assessing?
The Kronos Early Estrogen Prevention Study (KEEPS) is an ongoing trial of women 42 to 58 years of age who are within 36 months of their final menstrual period and who were randomized to estrogen replacement in low doses (0.45 mg of CEE), transdermal formulation (50 g/wk), or combined with cyclic oral, micronized progesterone 200 mg for 12 days each month. The primary outcomes are progression of subclinical atherosclerosis as measured by carotid intima-media thickness and coronary calcium scores, rather than stroke.