What are the effects of digoxin on mortality and morbidity in patients with heart failure?
The Digitalis Investigation Group study found that digoxin had a small but significant effect on mortality and morbidity in patients with heart failure. Mortality was reduced by 7% and morbidity reduced by 16%. The study also found that the use of digoxin was associated with a reduction in the risk of hospitalization for heart failure. The effects were greater in patients with lower ejection fractions. The study concluded that digoxin may be useful in the management of heart failure, especially in patients with lower ejection fractions.  