6/30/23, 2:22 AM TTM Pathway Feedback Search Clinical Topics Home Studies TTM TTM Disease Cardiac arrest Trial question What is the role of targeted temperature at 33 degree C in unconscious adults after out-of-hospital cardiac arrest? Study design Multi-center Single blinded RCT Population Characteristics of study participants 19.2% female N = 950 80.8% male 950 patients (178 female, 761 male) Inclusion criteria: unconscious adults after out-of-hospital cardiac arrest of presumed cardiac cause Key exclusion criteria: interval from the ROSC to screening > 240 minutes, unwitnessed arrest with asystole as the initial rhythm, acute intracranial hemorrhage or stroke, and a body temperature < 30 degree C Interventions N=473 cooling to 33 degree C (target body temperature of 33 degree C) N=466 cooling to 36 degree C (target body temperature of 36 degree C) https://web.pathway.md/studies/recg1Lxcak1p1uubB 1/2 6/30/23, 2:22 AM TTM Pathway Primary outcome All-cause death 50.0 % 50 48 37.5 % 25.0 % 12.5 % No significant difference 0.0 % Cooling to 33 degree C Cooling to 36 degree C No significant difference in all-cause death (50% vs. 48%; HR 1.06, 95% CI 0.89 to 1.28) Secondary outcomes No significant difference in poor neurologic function (CPC scale) or death at 6 months (54% vs. 52%; HR 1.02, 95% CI 0.88 to 1.16) No significant difference in poor neurologic function by mRS or death at 6 months (52% vs. 52%; HR 1.01, 95% CI 0.89 to 1.14) Conclusion In unconscious adults after out-of-hospital cardiac arrest of presumed cardiac cause, cooling to 33 degree C was not superior to cooling to 36 degree C with respect to a all-cause death. Reference Nielsen N, Wetterslev J, Cronberg T et al. Targeted temperature management at 33 C versus 36 C after cardiac arrest. N Engl J Med. 2013 Dec 5;369(23):2197-206. Open reference URL https://web.pathway.md/studies/recg1Lxcak1p1uubB 2/2