What are the effects of ivabradine in patients with left ventricular dysfunction?
Manz et al. (2003) conducted a study to assess the effects of a single intravenous dose of ivabradine in adult patients with left ventricular dysfunction. They found that ivabradine was able to lower heart rate without depressing left ventricular function. Tardif et al. (2005) also conducted a study and found that ivabradine was as effective as atenolol in reducing symptoms of chronic stable angina in patients with left ventricular dysfunction. Fox et al. (2008) conducted a randomized, double-blind, placebo-controlled trial and found that ivabradine was able to reduce symptoms of stable coronary artery disease and left ventricular systolic dysfunction. These studies suggest that ivabradine may be an effective treatment for patients with left ventricular dysfunction. 