6/28/23, 12:28 AM Corticosteroid injection for AT Pathway Feedback Search Clinical Topics Home Studies Corticosteroid injection for AT Corticosteroid injection for AT Disease Achilles tendinopathy Trial question What is the role of US-guided corticosteroid injection in patients with Achilles tendinopathy? Study design Multi-center Double blinded RCT Population Characteristics of study participants 40.0% female N = 100 60.0% male 100 patients (40 female, 60 male) Inclusion criteria: adult patients with ultrasound-verified Achilles tendinopathy for 3 months Key exclusion criteria: Achilles tendon rupture or surgery in the symptomatic lower limb; known medical diseases; corticosteroid injection for Achilles tendon pain within the past 6 months; BMI > 30 Interventions N=48 US-guided corticosteroid injection (1-3 injections of 1 mL methylprednisolone acetate 40 mg/mL and 1 mL lidocaine 10 mg/mL over 3 months plus exercise therapy) N=52 US-guided placebo injection (1-3 injections of 1 mL intralipid and 1 mL lidocaine 10 mg/mL over 3 months plus exercise therapy) Primary outcome Improvement in Victorian Institute of Sports Assessment-Achilles score at 6 months 39.0 39 https://web.pathway.md/studies/recTdCXKPucvfwihj 1/2 6/28/23, 12:28 AM Corticosteroid injection for AT Pathway 29.3 22 19.5 9.8 Significant increase 0.0 Ultrasound-guided corticosteroid injection Ultrasound-guided placebo injection Significant increase in improvement in Victorian Institute of Sports Assessment-Achilles score at 6 months (39 vs. 22; AD 17.7, 95% CI 8.4 to 27) Secondary outcomes Significant increase in improvement in the ultrasound-measured thickness of Achilles tendon at 3 months (2.6 vs. 0.6; AD 2.2, 95% CI 1.5 to 3) Significant increase in improvement in morning pain on Visual Analog Scale at 2 months (34 vs. 18; AD 15.6, 95% CI 2.6 to 28.6) Safety outcomes No significant difference in injection pain. Conclusion In adult patients with ultrasound-verified Achilles tendinopathy for 3 months, US-guided corticosteroid injection was superior to US-guided placebo injection with respect to improvement in Victorian Institute of Sports Assessment-Achilles score at 6 months. Reference Finn Johannsen, Jens Lykkegaard Olesen, Tommy Frisgaard hlenschl ger et al. Effect of Ultrasonography-Guided Corticosteroid Injection vs Placebo Added to Exercise Therapy for Achilles Tendinopathy: A Randomized Clinical Trial. JAMA Netw Open. 2022 Jul 1;5(7):e2219661. Open reference URL https://web.pathway.md/studies/recTdCXKPucvfwihj 2/2