6/28/23, 11:19 PM MR RESCUE Pathway Feedback Search Clinical Topics Home Studies MR RESCUE MR RESCUE Disease Acute ischemic stroke Trial question What is the role of endovascular thrombectomy in patients with acute ischemic stroke? Study design Multi-center Open label RCT Population Characteristics of study participants 52.0% female N = 118 48.0% male 118 patients (61 female, 57 male) Inclusion criteria: patients within 8 hours after the onset of large-vessel, anterior-circulation strokes Key exclusion criteria: acute intracranial hemorrhage, coma, NIHSS 30, rapidly improving neurological signs, pregnancy, pre-existing medical, neurological or psychiatric disease, or contraindication to MRI Interventions N=64 mechanical embolectomy (within 8 hours after the onset of symptoms, with Merci Retriever or Penumbra System) N=54 standard care (conforming with AHA/American Stroke Association guidelines) https://web.pathway.md/studies/rectQUYWfPQIb4S9R 1/2 6/28/23, 11:19 PM MR RESCUE Pathway Primary outcome Modified Rankin Scale score, with a favorable penumbral pattern 3.9 3.9 3.4 2.9 1.9 1.0 No significant difference 0.0 Mechanical embolectomy Standard care No significant difference in mRS score, with a favorable penumbral pattern (3.9 vs. 3.4; AD 0.5, 95% CI -0.31 to 1.31) Secondary outcomes No significant difference in mRS score, with a nonpenumbral pattern (4 vs. 4.4; AD -0.4, 95% CI -1.18 to 0.38) Safety outcomes No significant difference in death from all causes at 90 days or hemorrhage. Conclusion In patients within 8 hours after the onset of large-vessel, anterior-circulation strokes, mechanical embolectomy was not superior to standard care with respect to mRS score, with a favorable penumbral pattern. Reference Kidwell CS, Jahan R, Gornbein J et al. A trial of imaging selection and endovascular treatment for ischemic stroke. N Engl J Med. 2013 Mar 7;368(10):914-23. Open reference URL https://web.pathway.md/studies/rectQUYWfPQIb4S9R 2/2