What was the eligibility criteria for the WAKE-UP RCT?
Eligibility for the WAKE-UP RCT required a stroke with unclear time of onset and MRI mismatch between abnormal signal on DW-MRI and no visible signal change on FLAIR. DW-MRI lesions larger than one-third of the territory of the MCA, NIHSS score >25, contraindication to treatment with alteplase, or planned thrombectomy were all exclusions.