What randomized trials have been conducted regarding uninterrupted warfarin and catheter ablation?
A randomized trial of 1,584 patients showed that uninterrupted warfarin, compared with interruption with heparin bridging, has been shown to have a lower risk of periprocedural stroke and bleeding.298 A randomized trial of uninterrupted rivaroxaban vs uninterrupted VKA in AF ablation demonstrated similar event rates in both arms.299 A similar randomized trial of uninterrupted dabigatran found that dabigatran was associated with fewer bleeding complications than uninterrupted warfarin.300