What are the recommendations for the use of IV alteplase in patients with AIS who have undergone a major surgery in the preceding 14 days?
Use of IV alteplase in carefully selected patients presenting with AIS who have undergone a major surgery in the preceding 14 days may be considered, but the potential increased risk of surgical-site hemorrhage should be weighed against the anticipated benefits of reduced stroke related neurological deficits. (COR IIb; LOE C-LD)