What are the potential non-hemorrhagic side effects of heparin?
In addition to hemorrhagic complications, heparin has other nonhemorrhagic side effects that are very uncommon, including skin reactions that can progress to necrosis, alopecia, and hypersensitivity reactions. Additionally, heparin can cause drug-induced heparin resistance, bone metabolism abnormalities that can lead to osteoporosis, and immune-mediated platelet activation that can lead to heparin-induced thrombocytopenia (HIT). 