6/28/23, 10:55 PM GLUCONTROL Pathway Feedback Search Clinical Topics Home Studies GLUCONTROL GLUCONTROL Disease In-hospital hyperglycemia Trial question Is intensive glucose control superior to intermediate glucose control in patients in the ICU? Study design Multi-center Open label RCT Population Characteristics of study participants 37.0% female N = 1078 63.0% male 1078 patients (400 female, 678 male) Inclusion criteria: adult patients admitted to medical or surgical ICUs Key exclusion criteria: life expectancy below 24 hours; absence of informed consent Interventions N=536 intensive glucose control (blood glucose target 4.4-6.1 mmol/L) N=542 intermediate glucose control (blood glucose target 7.8-10.0 mmol/L) Primary outcome Death from any cause in intensive care unit 17.2 % 17.2 15.3 12.9 % 8.6 % https://web.pathway.md/studies/rec1pl3YPjZYp0sii 1/2 6/28/23, 10:55 PM GLUCONTROL Pathway 4.3 % No significant difference 0.0 % Intensive glucose control Intermediate glucose control No significant difference in death from any cause in the ICU (17.2% vs. 15.3%; AD 1.9%, 95% CI -2.55 to 6.35) Secondary outcomes No significant difference in death from any cause at day 28 (18.7% vs. 15.3%; AD 3.4%, 95% CI -1.11 to 7.91) No significant difference in death in the hospital at day 28 (23.3% vs. 19.4%; AD 3.9%, 95% CI -0.88 to 8.68) Safety outcomes Significant difference in hypoglycemia (8.7% vs. 2.7%). Conclusion In adult patients admitted to medical or surgical ICUs, intensive glucose control was not superior to intermediate glucose control with respect to death from any cause in the ICU. Reference Jean-Charles Preiser, Philippe Devos, Sergio Ruiz-Santana et al. A prospective randomised multi-centre controlled trial on tight glucose control by intensive insulin therapy in adult intensive care units: the Glucontrol study. Intensive Care Med. 2009 Oct;35(10):1738-48. Open reference URL https://web.pathway.md/studies/rec1pl3YPjZYp0sii 2/2