what are the Recommendations for Primary Severe Hypercholesterolemia
(LDL-C ≥190 mg/dL [≥4.9 mmol/L])
Referenced studies that support recommendations are summarized
in Online Data Supplements 9 and 10.?
In patients 40 to 75 years of age with a baseline LDL-C level of 220 mg/dL or higher (?5.7 mmol/L) and who achieve an on-treatment LDL-C level of 130 mg/ dL or higher (?3.4 mmol/L) while receiving maximally tolerated statin and ezetimibe therapy, the addition of a PCSK9 inhibitor may be considered.S