7/5/23, 10:37 AM Third-degree (complete) atrioventricular block - UpToDate Official reprint from UpToDate www.uptodate.com 2023 UpToDate, Inc. and/or its affiliates. All Rights Reserved. Third-degree (complete) atrioventricular block : William H Sauer, MD : Mark S Link, MD : Susan B Yeon, MD, JD, FACC All topics are updated as new evidence becomes available and our peer review process is complete. Literature review current through: Jun 2023. This topic last updated: Oct 13, 2022. INTRODUCTION Atrioventricular (AV) block is defined as a delay or interruption in the transmission of an impulse from the atria to the ventricles due to an anatomical or functional impairment in the conduction system. The conduction disturbance can be transient or permanent, with conduction that is delayed, intermittent, or absent. Commonly used terminology includes: First-degree AV block Slowed conduction without missed beats. Second-degree AV block Missed beats, often in a regular pattern (eg, 2:1, 3:2), or higher degrees of block, which is further classified into Mobitz type I (Wenckebach) and Mobitz II AV block. Third-degree (complete AV) block No atrial impulses reach the ventricle. High-grade AV block Intermittent atrial conduction to the ventricle with two or more consecutive blocked P waves but without complete AV block. The clinical presentation, evaluation, and management of acquired third-degree (complete) AV block will be discussed here. Congenital third-degree (complete) heart block, the etiology of AV block in general, and the management of other specific types of AV block are discussed separately. (See "Etiology of atrioventricular block" and "Congenital third-degree (complete) atrioventricular block" and "First-degree atrioventricular block" and "Second-degree atrioventricular block: Mobitz type I (Wenckebach block)" and "Second-degree atrioventricular block: Mobitz type II".) https://www.uptodate.com/contents/third-degree-complete-atrioventricular-block/print 1/18 7/5/23, 10:37 AM Third-degree (complete) atrioventricular block - UpToDate ETIOLOGY The potential etiologies of third-degree (complete) AV block are similar to lesser degrees of AV block and include reversible causes (both pathologic and iatrogenic) as well as idiopathic causes ( table 1). Common potentially reversible causes include: Pathologic Myocardial ischemia (acute or chronic) involving the conduction system, cardiomyopathy (eg, amyloidosis, sarcoidosis), myocarditis (eg, Lyme disease or COVID-19), endocarditis with abscess formation, hyperkalemia, profound hypothyroidism (myxedema), and hypervagotonia. Iatrogenic Medication-related (AV nodal blocking medications), post-cardiac surgery, post-catheter ablation, post-transcatheter aortic valve implantation. Other pathologic causes may be progressive or irreversible (eg, infiltrative malignancies, neuromuscular diseases). However, in half of more of the cases, no specific reversible causes are identified, and the block is felt to be related to idiopathic progressive cardiac conduction disease with myocardial fibrosis and/or sclerosis that affects the conduction system. A more extensive discussion of the etiology of AV block is presented separately. Congenital complete heart block is generally irreversible. (See "Etiology of atrioventricular block".) CLINICAL PRESENTATION AND EVALUATION The clinical presentation of third-degree (complete) AV block is variable depending upon the rate of the underlying escape rhythm and the presence of comorbid conditions. The evaluation of all patients with suspected third-degree (complete) AV block includes a thorough history, including medications and recent changes in medications, along with a 12-lead electrocardiogram (ECG) and bloodwork (which includes serum electrolytes and thyroid-stimulating hormone [TSH]). Clinical history All patients with suspected third-degree (complete) AV block should be questioned about any history of heart disease, both congenital and acquired, as well as any recent cardiac procedures that could predispose to AV conduction abnormalities. Patients without known cardiac disease should be questioned about other systemic diseases associated with heart block (eg, amyloidosis, sarcoidosis). Patients who live in an area with endemic Lyme disease should be questioned about any recent outdoor exposure to ticks or known tick bites. Congenital heart block can be associated with maternal lupus. (See 'Etiology' above and "Congenital third-degree (complete) atrioventricular block".) https://www.uptodate.com/contents/third-degree-complete-atrioventricular-block/print 2/18 7/5/23, 10:37 AM Third-degree (complete) atrioventricular block - UpToDate Patients with suspected third-degree (complete) AV block that occurs in the setting of acute myocardial ischemia or infarction should undergo concurrent diagnosis and treatment for both conditions. (See "Conduction abnormalities after myocardial infarction", section on 'Management of conduction abnormalities'.) Patients should provide a full list of medications and be questioned about any recent changes in dosing, with particular attention paid to drugs that alter AV nodal conduction (ie, beta blockers, non-dihydropyridine calcium channel blockers, digoxin, select antiarrhythmic drugs). In patients under 60 years of age who present with otherwise unexplained heart block, previously undetected cardiac sarcoidosis has been identified in up to 25 to 35 percent of patients [1,2]. Such patients with otherwise unexplained complete heart block should be evaluated for cardiac sarcoidosis [3]. (See "Clinical manifestations and diagnosis of cardiac sarcoidosis".) Signs and symptoms Nearly all patients with third-degree (complete) AV block will present with some degree of symptoms, though the severity of the symptoms can be quite variable. Symptoms may include: Fatigue Dyspnea Chest pain Presyncope or syncope Sudden cardiac arrest Most patients will present with some level of fatigue and/or dyspnea. These symptoms result from the reduced cardiac output associated with the slower ventricular rate (40 beats per minute or less) of most escape rhythms. Infrequently, patients with a faster escape rhythm (50 to 60 beats per minutes) may have minimal or no symptoms. Conversely, patients with a slower escape rhythm (30 beats per minute or less) are more likely to present with syncope. The absence of any escape rhythm may rarely lead to sudden cardiac death. The new onset of bradycardia associated with third-degree (complete) AV block may also exacerbate comorbid conditions. Patients with underlying coronary heart disease or heart failure may present with abrupt worsening of their typical angina or heart failure symptoms. Very few patients will be entirely asymptomatic with third-degree (complete) AV block. The complete absence of symptoms is likely to be seen only in relatively young, otherwise healthy patients with a high junctional escape rhythm and a ventricular heart rate greater than 40 beats per minute. https://www.uptodate.com/contents/third-degree-complete-atrioventricular-block/print 3/18 7/5/23, 10:37 AM Third-degree (complete) atrioventricular block - UpToDate Patients with third-degree (complete) AV block present with bradycardia but otherwise have few specific physical examination findings. Patients may appear pale or diaphoretic related to the abrupt reduction in cardiac output. Patients with underlying heart failure that is exacerbated by the development of heart block may have crackles on lung examination, elevated jugular venous pulsations, and/or peripheral edema. Electrocardiographic findings Patients with third-degree (complete) AV block will have evidence of atrial (P waves) and ventricular (QRS complexes) activity which are independent of each other on the surface electrocardiogram (ECG) ( waveform 1). In nearly all cases, the atrial rate will be faster than the ventricular escape rate, and there will be no association between the P waves and QRS complexes. As a general rule, the more distal the level of block and the resulting escape rhythm, the slower the ventricular rate will be. Junctional rhythms tend to have a ventricular rate between 40 and 60 beats per minute, while ventricular escape rhythms typically have rates of 40 beats per minute or less and often are unstable. Escape rhythms occur when a pacemaker other than the sinus node has sufficient time to depolarize, attain threshold, and produce a depolarization. In third-degree (complete) AV block, the escape rhythm that controls the ventricles can occur at any level below that of the conduction block and the morphology of the QRS complex can help to determine the location where this is occurring [4-6]. If third-degree AV block occurs within the AV node, about two-thirds of the escape rhythms have a narrow QRS complex (ie, a junctional or AV nodal rhythm) ( waveform 1) [7-9]. Block at the level of the bundle of His is also typically associated with a narrow QRS complex. Patients with infrahisian block have a subjunctional escape rhythm with a wide QRS complex ( waveform 2). If the escape rhythm has a normal QRS duration of less than 120 msec, the block occurs with almost equal frequency in the AV node and the bundle of His [7]. In comparison, involvement of these sites is infrequent with a prolonged QRS; the block in this setting is in the fascicles or bundle branches in over 80 percent of cases [7]. Patients in whom the development of third-degree (complete) AV block exacerbates underlying coronary heart disease may have ECG changes consistent with myocardial ischemia (eg, ST segment and T wave changes). Differential diagnosis of ECG findings Third-degree (complete) AV block has a relatively unique appearance on the ECG, with evidence of atrial (P waves) and ventricular (QRS https://www.uptodate.com/contents/third-degree-complete-atrioventricular-block/print 4/18 7/5/23, 10:37 AM Third-degree (complete) atrioventricular block - UpToDate complexes) activity which are independent of each other and an atrial rate faster than the ventricular rate. Rarely, complete AV block can occur in which the atrial rate is exactly twice the ventricular rate (eg, atrial rate of 80 beats per minute with a ventricular rate of 40 beats per minute), in which case the appearance on ECG could be similar to that of second-degree AV (ie, 2:1) block. However, any slight variation in the exact multiples should result in variations on the ECG that allow the distinction between third-degree (complete) AV block and second-degree AV block. Electrophysiology study With a very few select exceptions, electrophysiologic studies (EPS) are not necessary in patients with complete AV block [10,11]. Among patients with complete AV block, EPS may be indicated when symptoms are not present, the site of block is not apparent, or the block is potentially reversible. (See "Lyme carditis", section on 'Atrioventricular conduction abnormalities'.) DIAGNOSIS In nearly all cases, the diagnosis of third-degree (complete) AV block can be made in a patient with suggestive symptoms (eg, fatigue, dyspnea, presyncope, and/or syncope) by obtaining a surface electrocardiogram (ECG), ideally a full 12-lead ECG but sometime a single-lead rhythm strip is adequate if a full 12-lead ECG cannot be obtained. For the rare patient with a nondiagnostic surface ECG, invasive electrophysiology studies can definitively diagnose third- degree (complete) AV block and accurately identify the level of the block. MANAGEMENT The initial management of the patient with third-degree (complete) AV block depends on the presence and severity of any signs and symptoms related to the ventricular escape rhythm ( algorithm 1). Unstable patients require immediate pharmacologic therapy and, in most instances, should also receive temporary pacing to increase heart rate and cardiac output. Once the patient is hemodynamically stable, assessment and treatment for any potentially reversible causes should occur, followed by placement of a permanent pacemaker for patients without an identifiable reversible etiology [11]. Unstable patients Patients with third-degree (complete) AV block who are hemodynamically unstable should be urgently treated ( algorithm 1) with atropine, beta-adrenergic agonists, and/or temporary cardiac pacing (either with transcutaneous or, if immediately available, https://www.uptodate.com/contents/third-degree-complete-atrioventricular-block/print 5/18 7/5/23, 10:37 AM Third-degree (complete) atrioventricular block - UpToDate transvenous pacing). Beta-adrenergic agonists may be helpful, particularly in patients with block at the AV node. (See "Advanced cardiac life support (ACLS) in adults", section on 'Bradycardia'.) The most important clinical determination in a patient presenting with a third-degree (complete) AV block is whether or not the patient is hemodynamically unstable due to the resulting bradycardia and reduced cardiac output. Signs and symptoms of hemodynamic instability include hypotension, altered mental status, signs of shock, ongoing ischemic chest pain, and evidence of acute pulmonary edema. Such patients should be treated according to the Advanced Cardiac Life Support protocol for patients with symptomatic bradycardia ( algorithm 2) [12]: Atropine should be promptly administered if intravenous (IV) access is available, but treatment with atropine should not delay treatment with transcutaneous pacing or a chronotropic agent. The initial dose of atropine is 1 mg IV. This dose may be repeated every three to five minutes to a total dose of 3 mg. A favorable response to atropine also suggests that AV block is due to abnormal conduction in the AV node. Atropine is not likely to be effective for patients with an escape rhythm at or below the bundle of His since the more distal conducting system is not as sensitive to vagal activity. Atropine is contraindicated in patients with closed angle glaucoma, pyloric stenosis, myasthenia gravis, urinary retention/bladder obstruction, and other conditions. Temporary cardiac pacing should be provided. In the absence of central venous access, the most immediate way to provide temporary cardiac pacing is via transcutaneous pacing. Transcutaneous pacing is uncomfortable for the patient and may have variable efficacy depending on how well the impulses are transmitted to the myocardium; as such, transcutaneous pacing should be viewed as a temporizing measure until temporary transvenous pacing can be provided. (See "Temporary cardiac pacing".) In patients with hypotension associated with third-degree (complete) AV block, we administer dopamine via IV infusion, beginning at a dose of 5 mcg/kg/minute and titrating up to 20 mcg/kg/minute if needed for heart rate and blood pressure augmentation [13]. Our contributors do not use epinephrine in this setting but others do ( algorithm 2). Isoproterenol can also be used, with an initial infusion of 1 to 5 mcg/min, which is titrated to as high as 20 mcg/min based upon heart rate response. In patients with heart failure with reduced ejection fraction (HFrEF) associated with third- degree (complete) AV block, we administer dobutamine via IV infusion, beginning at a dose of 2 to 5 mcg/kg/minute and titrating as needed until an optimal clinical and hemodynamic response is achieved. The usual maintenance dose of dobutamine is 2 to 10 mcg/kg/min (maximum 20 mcg/kg/min). https://www.uptodate.com/contents/third-degree-complete-atrioventricular-block/print 6/18 7/5/23, 10:37 AM Third-degree (complete) atrioventricular block - UpToDate Once a hemodynamically unstable patient has been stabilized, the approach to further management is the same as for patients who were initially stable. (See 'Stable patients' below.) Stable patients Patients with third-degree (complete) AV block who are hemodynamically stable do not require urgent therapy with atropine or temporary cardiac pacing. However, many ventricular escape rhythms are unreliable and potentially unstable, so patients should be continuously monitored with transcutaneous pacing pads in place in the event of clinical deterioration ( algorithm 1). In addition, most stable patients continue to have symptoms related to the bradycardia and will require identification and treatment of any reversible causes or permanent therapy with an implantable pacemaker. While stable patients are being monitored, evaluation and treatment should proceed as follows: Reversible causes of third-degree (complete) AV block such as myocardial ischemia, increased vagal tone, hypothyroidism, hyperkalemia, and drugs that depress conduction, should be excluded in patients prior to implantation of a permanent pacemaker. Patients with third-degree (complete) AV block in the setting of an acute myocardial infarction should be treated with temporary pacing and revascularization; following revascularization, most conduction abnormalities will improve or resolve and will not require permanent pacing. (See "Conduction abnormalities after myocardial infarction", section on 'Summary and recommendations'.) Patients with third-degree (complete) AV block felt to be medication-induced should be observed while the offending agent or agents are withdrawn; such patients will often have improvement or resolution of AV block following removal of the medication. If the medication is deemed necessary, permanent pacing is indicated. Patients with third-degree (complete) AV block in the setting of hyperkalemia should receive therapy to reduce serum potassium levels; similarly, patients with hypothyroidism should receive thyroid replacement therapy. If third-degree (complete) AV block subsequently resolves, a permanent pacemaker is not usually needed. (See "Treatment and prevention of hyperkalemia in adults" and "Treatment of primary hypothyroidism in adults".) Patients with Lyme carditis and associated heart block frequently do not require permanent cardiac pacing. Third-degree (complete) AV block typically improves to lesser degrees of AV block within one week, and more minor conduction disturbances usually resolve within six weeks. As such, while these patients may initially require temporary cardiac pacing, permanent cardiac pacing should be reserved for patients with https://www.uptodate.com/contents/third-degree-complete-atrioventricular-block/print 7/18 7/5/23, 10:37 AM Third-degree (complete) atrioventricular block - UpToDate persistent third-degree (complete) AV block following an adequate course of therapy for Lyme disease. (See "Lyme carditis".) Patients who develop complete heart block after TAVR generally require permanent pacemakers, and should initially be treated with temporary transvenous pacing. Guidelines for patients with less severe conduction abnormalities after TAVR have been developed [14]. (See "Transcatheter aortic valve implantation: Complications".) Transient vagally mediated heart block, often seen on hospital telemetry during sleep, generally does not require specific intervention. Pacing is controversial in vagally mediated syncope, particularly in younger patients. If no reversible causes are present, definitive treatment of third-degree (complete) AV block generally involves permanent pacemaker placement [10,11]. Dual-chamber (ie, atrioventricular) to maintain AV synchrony is preferred (rather than single chamber right ventricular pacing) in most patients due to the favorable hemodynamic benefits of AV synchrony [11]. Some trials suggest that biventricular cardiac pacing (ie, cardiac resynchronization) is superior to standard dual chamber pacing in patients with heart block [15,16]. Implantable cardioverter-defibrillators, specifically cardiac resynchronization therapy devices (CRT-Ds), should be considered in patients with complete AV block and significant left ventricle dysfunction. Conducting system pacing (His- bundle or left-bundle pacing) has emerged as an alternative to CRT pacing [17,18]. Leadless pacing may be appropriate in selected patients. (See "Permanent cardiac pacing: Overview of devices and indications" and "Modes of cardiac pacing: Nomenclature and selection".) SOCIETY GUIDELINE LINKS Links to society and government-sponsored guidelines from selected countries and regions around the world are provided separately. (See "Society guideline links: Arrhythmias in adults" and "Society guideline links: Cardiac implantable electronic devices".) INFORMATION FOR PATIENTS UpToDate offers two types of patient education materials, "The Basics" and "Beyond the Basics." th th The Basics patient education pieces are written in plain language, at the 5 to 6 grade reading level, and they answer the four or five key questions a patient might have about a given condition. These articles are best for patients who want a general overview and who prefer short, easy-to-read materials. Beyond the Basics patient education pieces are longer, more th th sophisticated, and more detailed. These articles are written at the 10 to 12 grade reading https://www.uptodate.com/contents/third-degree-complete-atrioventricular-block/print 8/18 7/5/23, 10:37 AM Third-degree (complete) atrioventricular block - UpToDate level and are best for patients who want in-depth information and are comfortable with some medical jargon. Here are the patient education articles that are relevant to this topic. We encourage you to print or e-mail these topics to your patients. (You can also locate patient education articles on a variety of subjects by searching on "patient info" and the keyword(s) of interest.) Basics topics (see "Patient education: Bradycardia (The Basics)" and "Patient education: Heart block in adults (The Basics)") SUMMARY AND RECOMMENDATIONS Definition and etiology In third-degree (complete) atrioventricular (AV) block, no atrial impulses reach the ventricle. Third-degree (complete) AV block can occur in the AV node or in the infranodal specialized conduction system. The potential etiologies of third-degree (complete) AV block include reversible causes (both pathologic and iatrogenic) as well as idiopathic causes. Common potentially reversible causes include myocardial ischemia, medications, and cardiac procedures. (See 'Introduction' above and 'Etiology' above and "Etiology of atrioventricular block".) Clinical presentation The clinical presentation of third-degree (complete) AV block varies depending upon the rate of the underlying escape rhythm and the presence of comorbid conditions. Nearly all patients with third-degree (complete) AV block will present with some degree of symptoms, though the severity of the symptoms can be quite variable. Most patients will present with some level of fatigue and/or dyspnea, and very few patients will be entirely asymptomatic. (See 'Signs and symptoms' above.) ECG findings Patients with third-degree (complete) AV block will have evidence of atrial (P waves) and ventricular (QRS complexes) activity which are independent of each other on the surface ECG. In complete heart block, the escape rhythm can occur at any level below that of the conduction block, and the morphology of the QRS complex can help to determine the location at which this is occurring. If third-degree AV block occurs within the AV node or the bundle of His, the escape rhythm tends to have a narrow QRS complex, whereas AV block occurring below the bundle of His (ie, infrahisian block) results in a subjunctional escape rhythm with a wide QRS complex. (See 'Electrocardiographic findings' above.) Diagnosis In nearly all cases, the diagnosis of third-degree (complete) AV block can be made in a patient with suggestive symptoms (eg, fatigue, dyspnea, presyncope, and/or https://www.uptodate.com/contents/third-degree-complete-atrioventricular-block/print 9/18 7/5/23, 10:37 AM Third-degree (complete) atrioventricular block - UpToDate syncope) by obtaining a surface ECG, ideally a full 12-lead ECG but sometime a single-lead rhythm strip is adequate if a full 12-lead ECG cannot be obtained. (See 'Diagnosis' above.) Initial management Initial treatment of the patient with third-degree (complete) AV block depends on the presence and severity of any signs and symptoms related to the ventricular escape rhythm ( algorithm 1). (See 'Management' above.) Hemodynamically unstable Unstable patients require immediate pharmacologic therapy and, in most instances, temporary pacing to increase heart rate and cardiac output. Atropine (initial dose 1 mg intravenously [IV]) should be promptly administered if IV access is available, but treatment with atropine should not delay treatment with transcutaneous pacing or a chronotropic agent. Temporary cardiac pacing should be provided. In the absence of central venous access, the most immediate way to provide temporary cardiac pacing is via transcutaneous pacing (see 'Unstable patients' above and "Temporary cardiac pacing"). Beta-adrenergic agonists may also be helpful in some patients with complete heart block. Hemodynamically stable Patients with third-degree (complete) AV block who are initially hemodynamically stable do not require urgent therapy with atropine or temporary cardiac pacing. However, many ventricular escape rhythms are unreliable and potentially unstable, so patients should be continuously monitored with transcutaneous pacing pads in place in the event of clinical deterioration. (See 'Stable patients' above.) Subsequent management Once the patient is hemodynamically stable, reversible causes of third-degree (complete) AV block such as myocardial ischemia, increased vagal tone, hypothyroidism, hyperkalemia, and drugs that depress conduction, should be excluded in patients prior to implantation of a permanent pacemaker. (See 'Stable patients' above.) Once reversible causes of heart block have been excluded, permanent pacing is generally indicated. (See 'Stable patients' above.) ACKNOWLEDGMENT The UpToDate editorial staff acknowledges Leonard Ganz, MD, FHRS, FACC, who contributed to earlier versions of this topic review. Use of UpToDate is subject to the Terms of Use. https://www.uptodate.com/contents/third-degree-complete-atrioventricular-block/print 10/18 7/5/23, 10:37 AM Third-degree (complete) atrioventricular block - UpToDate REFERENCES 1. Takaya Y, Kusano KF, Nakamura K, Ito H. Outcomes in patients with high-degree atrioventricular block as the initial manifestation of cardiac sarcoidosis. Am J Cardiol 2015; 115:505. 2. Nery PB, Beanlands RS, Nair GM, et al. Atrioventricular block as the initial manifestation of cardiac sarcoidosis in middle-aged adults. J Cardiovasc Electrophysiol 2014; 25:875. 3. Birnie DH, Sauer WH, Bogun F, et al. HRS expert consensus statement on the diagnosis and management of arrhythmias associated with cardiac sarcoidosis. Heart Rhythm 2014; 11:1305. 4. Narula OS, Javier RP, Samet P, Maramba LC. Significance of His and left bundle recordings from the left heart in man. Circulation 1970; 42:385. 5. Narula OS, Scherlag BJ, Javier RP, et al. Analysis of the A-V conduction defect in complete heart block utilizing His bundle electrograms. Circulation 1970; 41:437. 6. Guimond C, Puech P. Intra-His bundle blocks (102 cases). Eur J Cardiol 1976; 4:481. 7. Peuch P, Grolleau R, Guimond C. Incidence of different types of A-V block and their localizati on by His bundle recordings. In: The Conduction System of the Heart, Wellens HJJ, Lie KI, Jan se MJ (Eds), Stenfert Kroese, Leiden 1976. p.467. 8. Narula OS. Current concepts of atrioventricular block. In: His Bundle Electrocardiography an d Clinical Electrophysiology, Narula OS (Ed), Davis, Philadelphia 1975. p.139. 9. Rosen KM, Dhingra RC, Loeb HS, Rahimtoola SH. Chronic heart block in adults. Clinical and electrophysiological observations. Arch Intern Med 1973; 131:663. 10. Brignole M, Auricchio A, Baron-Esquivias G, et al. 2013 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy: the Task Force on cardiac pacing and resynchronization therapy of the European Society of Cardiology (ESC). Developed in collaboration with the European Heart Rhythm Association (EHRA). Eur Heart J 2013; 34:2281. 11. Kusumoto FM, Schoenfeld MH, Barrett C, et al. 2018 ACC/AHA/HRS Guideline on the Evaluation and Management of Patients With Bradycardia and Cardiac Conduction Delay: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. J Am Coll Cardiol 2019; 74:e51. 12. Panchal AR, Bartos JA, Caba as JG, et al. Part 3: Adult Basic and Advanced Life Support: 2020 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation 2020; 142:S366. https://www.uptodate.com/contents/third-degree-complete-atrioventricular-block/print 11/18 7/5/23, 10:37 AM Third-degree (complete) atrioventricular block - UpToDate 13. Kusumoto FM, Schoenfeld MH, Barrett C, et al. 2018 ACC/AHA/HRS Guideline on the Evaluation and Management of Patients With Bradycardia and Cardiac Conduction Delay: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. Circulation 2019; 140:e382. 14. Rod s-Cabau J, Ellenbogen KA, Krahn AD, et al. Management of Conduction Disturbances Associated With Transcatheter Aortic Valve Replacement: JACC Scientific Expert Panel. J Am Coll Cardiol 2019; 74:1086. 15. Yu CM, Chan JY, Zhang Q, et al. Biventricular pacing in patients with bradycardia and normal ejection fraction. N Engl J Med 2009; 361:2123. 16. Curtis AB, Worley SJ, Adamson PB, et al. Biventricular pacing for atrioventricular block and systolic dysfunction. N Engl J Med 2013; 368:1585. 17. Upadhyay GA, Vijayaraman P, Nayak HM, et al. On-treatment comparison between corrective His bundle pacing and biventricular pacing for cardiac resynchronization: A secondary analysis of the His-SYNC Pilot Trial. Heart Rhythm 2019; 16:1797. 18. Sharma PS, Vijayaraman P, Ellenbogen KA. Permanent His bundle pacing: shaping the future of physiological ventricular pacing. Nat Rev Cardiol 2020; 17:22. Topic 911 Version 39.0 https://www.uptodate.com/contents/third-degree-complete-atrioventricular-block/print 12/18 7/5/23, 10:37 AM Third-degree (complete) atrioventricular block - UpToDate GRAPHICS Major causes of atrioventricular (AV) block Physiologic and pathophysiologic Increased vagal tone Progressive cardiac conduction system disease With fibrosis and/or sclerosis (Lenegre disease) With calcification (Lev disease) Ischemic heart disease, including acute myocardial infarction Cardiomyopathy Infiltrative processes (eg, sarcoidosis, amyloidosis, hemochromatosis, malignancy, etc) Other non-ischemic cardiomyopathies (eg, idiopathic, infectious, etc) Infections (eg, viral myocarditis, Lyme carditis) Congenital AV block Related to structural congenital heart disease As part of neonatal lupus syndrome Other Hyperkalemia, severe hypo- or hyperthyroidism, trauma, degenerative neuromuscular diseases Iatrogenic Drugs Beta blockers, calcium channel blockers, digoxin, adenosine, antiarrhythmic drugs Cardiac surgery Post valvular surgery, post surgical correction of congenital heart disease Transcatheter aortic valve implantation Catheter ablation of arrhythmias Transcatheter closure of VSD Alcohol septal ablation for HCM VSD: ventricular septal defect; HCM: hypertrophic cardiomyopathy. Graphic 62885 Version 6.0 https://www.uptodate.com/contents/third-degree-complete-atrioventricular-block/print 13/18 7/5/23, 10:37 AM Third-degree (complete) atrioventricular block - UpToDate Third degree (complete) atrioventricular block with narrow QRS escape rhythm The P waves are completely dissociated from the QRS complexes. The QRS complexes are narrow, indicating a junctional escape rhythm. The atrial and ventricular rates are stable; the former is faster than the latter. Graphic 65545 Version 5.0 Normal rhythm strip Normal rhythm strip in lead II. The PR interval is 0.15 sec and the QRS duration is 0.08 sec. Both the P and T waves are upright. Courtesy of Morton F Arnsdorf, MD. Graphic 59022 Version 3.0 https://www.uptodate.com/contents/third-degree-complete-atrioventricular-block/print 14/18 7/5/23, 10:37 AM Third-degree (complete) atrioventricular block - UpToDate Third degree (complete) atrioventricular block with wide QRS escape rhythm The P waves are completely dissociated from the QRS complexes and the PR intervals are variable. The atrial or PP rate (75 beats per minute) is faster than the ventricular or RR rate (30 beats per minute), establishing complete atrioventricular blockade as the etiology. The QRS complexes are wide indicating that the escape rhythm is ventricular. Graphic 51446 Version 5.0 Normal rhythm strip Normal rhythm strip in lead II. The PR interval is 0.15 sec and the QRS duration is 0.08 sec. Both the P and T waves are upright. Courtesy of Morton F Arnsdorf, MD. Graphic 59022 Version 3.0 https://www.uptodate.com/contents/third-degree-complete-atrioventricular-block/print 15/18 7/5/23, 10:37 AM Third-degree (complete) atrioventricular block - UpToDate Algorithm showing the treatment approach to the patient with complete heart block ECG: electrocardiogram; CHB: complete heart block; BP: blood pressure; HF: heart failure; IV: intravenous; PPM: permanent pacemaker. The initial dose of atropine is 1 mg IV. This dose may be repeated every 3 to 5 minutes to a total dose of 3 mg. While transcutaneous pacing may be initially successful in stabilizing the patient, it may not be consistently reliable. Central venous access should be considered in the event that urgent transvenous pacing is required. Dopamine IV infusion typically begins at a dose of 5 mcg/kg/minute and is titrated as needed to achieve an optimal clinical and hemodynamic response (maximum dose of 20 mcg/kg/minute). Dobutamine IV infusion typically begins at a dose of 2 to 5 mcg/kg/minute and is titrated as needed to achieve an optimal clinical and hemodynamic response. The usual maintenance dose of dobutamine is 2 to 10 mcg/kg/minute (maximum dose of 20 mcg/kg/minute). Graphic 103365 Version 7.0 https://www.uptodate.com/contents/third-degree-complete-atrioventricular-block/print 16/18 7/5/23, 10:37 AM Third-degree (complete) atrioventricular block - UpToDate Adult bradycardia algorithm 2020 update Reprinted with permission. ACLS Provider Manual. Copyright 2020 American Heart Association, Inc. Graphic 130748 Version 10.0 https://www.uptodate.com/contents/third-degree-complete-atrioventricular-block/print 17/18 7/5/23, 10:37 AM Third-degree (complete) atrioventricular block - UpToDate Contributor Disclosures William H Sauer, MD Grant/Research/Clinical Trial Support: Biosense-Webster [Catheter ablation]; Boston Scientific [Catheter ablation]. All of the relevant financial relationships listed have been mitigated. Mark S Link, MD No relevant financial relationship(s) with ineligible companies to disclose. Susan B Yeon, MD, JD, FACC No relevant financial relationship(s) with ineligible companies to disclose. Contributor disclosures are reviewed for conflicts of interest by the editorial group. When found, these are addressed by vetting through a multi-level review process, and through requirements for references to be provided to support the content. Appropriately referenced content is required of all authors and must conform to UpToDate standards of evidence. Conflict of interest policy https://www.uptodate.com/contents/third-degree-complete-atrioventricular-block/print 18/18