What are the GRADE guidelines for rating the quality of evidence imprecision?
The GRADE guidelines for rating the quality of evidence imprecision are outlined in Brunetti et al. (2011) and Shemilt et al. (2013). According to Brunetti et al. (2011), imprecision refers to the lack of sufficient information to quantify the magnitude of the effect of a particular intervention or outcome. They provide guidelines for assessing the quality of evidence based on four criteria: study design, study size, study quality, and confidence in the observed effect. Shemilt et al. (2013) provide further guidance for considering the use of resources when rating the quality of economic evidence. These guidelines can be found on the website of the International Society of Nephrology.  