What is the clinical and cost effectiveness of beta-blockers in the management of chronic heart failure in people with heart failure with reduced ejection fraction (HFREF) and atrial fibrillation?
A search was conducted for randomised trials comparing the effectiveness of beta-blockers versus placebo in addition to usual care in people with chronic heart failure and atrial fibrillation. One study Chronic Heart Failure Beta-blockers in heart failure and concomitant atrial fibrillation NICE 2018. All-cause mortality, health-related quality of life, unplanned hospitalization, other adverse events (stroke, bradycardia, hypotension), and improvement of NYHA class were identified as critical and important outcomes. Systematic reviews of RCTs and RCTs were used as study design.