6/28/23, 11:01 PM LOVIT Pathway Feedback Search Clinical Topics Home Studies LOVIT LOVIT Disease Sepsis and septic shock Trial question What is the role of intravenous vitamin C in adult patients with sepsis in the ICU? Study design Multi-center Double blinded RCT Population Characteristics of study participants 38.0% female N = 862 62.0% male 862 patients (324 female, 538 male) Inclusion criteria: adult patients with sepsis receiving vasopressor therapy in the ICU Key exclusion criteria: contraindication to vitamin C therapy; receipt of open-label vitamin C; expected death or withdrawal of life-sustaining therapy within 48 hours Interventions N=429 vitamin C (at a dose of 50 mg/kg of body weight every 6 hours for up to 96 hours) N=433 placebo (dextrose 5% in water or normal saline every 6 hours for up to 96 hours) Primary outcome Composite of death or persistent organ dysfunction at day 28 44.5 % 44.5 https://web.pathway.md/studies/recO3qtrEwNbN4kER 1/2 6/28/23, 11:01 PM LOVIT Pathway 5 38.5 33.4 % 22.3 % Significant increase 11.1 % NNH = 17 0.0 % Vitamin C Placebo Significant increase in composite of death or persistent organ dysfunction at day 28 (44.5% vs. 38.5%; RR 1.21, 95% CI 1.04 to 1.4) Secondary outcomes No significant difference in death at day 28 (35.4% vs. 31.6%; RR 1.17, 95% CI 0.98 to 1.4) No significant difference in median days without organ dysfunction at day 28 (17 days vs. 19.5 days; MD -2.43, 95% CI -7.23 to 2.37) No significant difference in sequential organ failure assessment score at day 28 (6.5 vs. 7.9; AD -1.42, 95% CI -3.98 to 1.14) Safety outcomes No significant differences in stage 3 AKI, hypoglycemia. Conclusion In adult patients with sepsis receiving vasopressor therapy in the ICU, vitamin C was inferior to placebo with respect to the composite of death or persistent organ dysfunction at day 28. Reference Fran ois Lamontagne, Marie-H l ne Masse, Julie Menard et al. Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit. N Engl J Med. 2022 Jun 23;386(25):2387-2398. Open reference URL https://web.pathway.md/studies/recO3qtrEwNbN4kER 2/2