What is the recommended dose for beta-blockers to limit the heart rate to 55 to 60 beats per minute at rest?
It is recommended that beta-blocker dosing be adjusted to limit the heart rate to 55 to 60 beats per minute at rest. In large prospective studies, bisoprolol, carvedilol, and metoprolol, when administered on a background of ACE inhibitors and diuretics with or without digoxin, have been shown to reduce the risk of death and to improve symptoms, clinical status, and quality of life in patients with chronic systolic heart failure.