What has been found regarding the relationship between HbA1c and outcomes in the CHARM trial?
In the total CHARM cohort, increasing levels of HbA1c were associated with increased risk of total mortality, HF hospitalization, and a composite outcome of cardiovascular death or HF hospitalization. Of note, the graded relationship between HbA1c and mortality was more pronounced in the nondiabetic patients enrolled in CHARM and did not reach statistical significance for the outcomes of cardiovascular death (P for heterogeneity=0.04) and total mortality (P for heterogeneity=0.008) in the cohort of HF patient with diabetes mellitus.