6/29/23, 1:13 AM ReCOVer Pathway Feedback Search Clinical Topics Home Studies ReCOVer ReCOVer Disease Disease COVID 19 infection Long COVID Trial question What is the effect of CBT on severe fatigue following COVID-19? Study design Multi-center Open label RCT Population Characteristics of study participants 73.0% female N = 114 27.0% male 114 patients (83 female, 31 male) Inclusion criteria: patients being severely fatigued 3-12 months following COVID-19 Key exclusion criteria: known psychiatric or somatic condition that can explain fatigue; current participation in a multi-disciplinary rehabilitation program aimed to ameliorate the consequences of COVID-19; objective hypoxemia at rest for which oxygen therapy at home is indicated Interventions N=57 CBT (targeting perpetuating factors of fatigue known as Fit after COVID, provided for 17 weeks) N=57 care as usual (no access to Fit after COVID, but not restricted in seeking care including psychological interventions for fatigue or other symptoms) https://web.pathway.md/studies/rechgo7mlSZoSlVKR 1/2 6/29/23, 1:13 AM ReCOVer Pathway Primary outcome Reduction in fatigue severity 39.9 39.9 31.1 29.9 19.9 10.0 Significant decrease 0.0 Cognitive behavioral therapy Care as usual Significant decrease in reduction in fatigue severity (31.1 vs. 39.9; AD -8.8, 95% CI -11.9 to -5.8) Secondary outcomes Significant increase in improvement in physical functioning (78.8 vs. 71.6; AD 7.1, 95% CI 2.9 to 11.3) Significant decrease in reduction in social impairment (11.8 vs. 18.4; AD -6.6, 95% CI -9.1 to -4.2) Significant decrease in reduction in somatic symptoms (8.2 vs. 10.1; AD -2, 95% CI -2.9 to -1) Conclusion In patients being severely fatigued 3-12 months following COVID-19, CBT was superior to care as usual with respect to reduction in fatigue severity. Reference Tanja A Kuut, Fabiola M ller, Irene Csorba et al. Efficacy of cognitive behavioral therapy targeting severe fatigue following COVID-19: results of a randomized controlled trial. Clin Infect Dis. 2023 May 8;ciad257. Open reference URL https://web.pathway.md/studies/rechgo7mlSZoSlVKR 2/2