What was the result of the combined post hoc analysis of SPRINT and ACCORD?
The combined post hoc analysis of SPRINT and ACCORD suggested similar CV benefits of intensive BP-lowering therapy in the presence or absence of diabetes. ACCORD reported no statistical interaction between glycemic control and BP control on pre-specified primary and secondary CV outcomes. However, a more detailed combined analysis of data from ACCORD and SPRINT found that the beneficial effects of intensive SBP control (with both trials targeting <120 mm Hg) on combined CV endpoints and on all-cause mortality were similar in the standard glycemia arm of ACCORD and in SPRINT. In contrast, intensive SBP control increased CV death, HF, and MI in the intensive glycemia arm.