6/28/23, 11:44 PM OSCILLATE Pathway Feedback Search Clinical Topics Home Studies OSCILLATE OSCILLATE Disease Acute respiratory distress syndr Trial question What is the role of high-frequency oscillatory ventilation in patients with early ARDS? Study design Multi-center Open label RCT Population Characteristics of study participants 41.3% female N = 1200 58.7% male 1200 patients (228 female, 320 male) Inclusion criteria: adults with new-onset, moderate-to-severe ARDS Key exclusion criteria: hypoxemia primarily related to LA hypertension, suspected vasculitic pulmonary hemorrhage, neuromuscular disorders, severe chronic respiratory disease, or preexisting conditions with an expected 6-month mortality > 50%, at risk for intracranial hypertension Interventions N=275 high-frequency oscillatory ventilation (targeting improved lung recruitment) N=273 low tidal volume ventilation (low tidal volumes and high PEEP) Primary outcome https://web.pathway.md/studies/recDgxiKlrJzu1htG 1/2 6/28/23, 11:44 PM OSCILLATE Pathway In-hospital death 47.0 % 47 35.3 % 35 23.5 % Significant increase 11.8 % NNH = 8 0.0 % High-frequency oscillatory ventilation Low tidal volume ventilation Significant increase in in-hospital death (47% vs. 35%; RR 1.33, 95% CI 1.09 to 1.64) Secondary outcomes No significant difference in new barotrauma (18% vs. 13%; RR 1.37, 95% CI 0.91 to 2.06) Significant decrease in refractory hypoxemia (7% vs. 14%; RR 0.5, 95% CI 0.29 to 0.84) No significant difference in refractory acidosis (3% vs. 3%; RR 1.12, 95% CI 0.44 to 2.85) Conclusion In adults with new-onset, moderate-to-severe ARDS, high-frequency oscillatory ventilation was inferior to low tidal volume ventilation with respect to a in-hospital death. Reference Ferguson ND, Cook DJ, Guyatt GH et al. High-frequency oscillation in early acute respiratory distress syndrome. N Engl J Med. 2013 Feb 28;368(9):795-805. Open reference URL https://web.pathway.md/studies/recDgxiKlrJzu1htG 2/2