What are the adverse events associated with intensive BP lowering in the CKD subgroup?
Within the CKD subgroup, SPRINT reported no significant difference in serious adverse events, and in adverse events associated with hypotension, postural hypotension, syncope, bradycardia, and injurious falls between the intensive (<120 mm Hg SBP) and standard (<140 mm Hg SBP) BP arms. There were increased risks for hypokalemia (HR: 1.87; 95% CI: 1.02 3.43) and hyperkalemia (HR: 1.36; 95% CI: 1.01 1.82), presumably because of the greater use of antihypertensive medications in the intensive BP arm.