6/29/23, 11:45 PM SPRINT-MIND Pathway Feedback Search Clinical Topics Home Studies SPRINT MIND SPRINT MIND Disease Disease Dementia Hypertension Trial question What is the effect of intensive BP control to reduce the risk of probable dementia in ambulatory adults with hypertension who were at an increased risk of CVD? Study design Multi-center Open label RCT Population Characteristics of study participants 36.0% female N = 9361 64.0% male 9361 patients (3332 female, 6029 male) Inclusion criteria: ambulatory adult patients ( 50 years of age) with hypertension but without diabetes or history of stroke who had an increased cardiovascular risk Key exclusion criteria: nursing home residents, diagnosis of dementia, use of dementia therapy medications, diabetes mellitus, history of stroke Interventions N=4678 intensive BP reduction (systolic BP goal of < 120 mmHg with antihypertensives) N=4683 standard BP management (systemic BP goal of < 140 mmHg with antihypertensive medications) https://web.pathway.md/studies/recDAGML8mqX75pXd 1/2 6/29/23, 11:45 PM SPRINT-MIND Pathway Primary outcome Incidence of adjudicated probable dementia at a median follow-up of 5.11 years 8.6/1000 py 8.6 7.2 6.4/1000 py 4.3/1000 py 2.1/1000 py No significant difference 0.0/1000 py Intensive blood pressure reduction Standard blood pressure management No significant difference in the incidence of adjudicated probable dementia at a median follow-up of 5.11 years (7.2 /1000 py vs. 8.6 /1000 py; HR 0.83, 95% CI 0.67 to 1.04) Secondary outcomes Significant decrease in the incidence of mild cognitive impairment (14.6 /1000 py vs. 18.3 /1000 py; HR 0.81, 95% CI 0.69 to 0.95) Significant decrease in mild cognitive impairment or probable dementia (20.2 vs. 24.1; HR 0.85, 95% CI 0.74 to 0.97) Safety outcomes No significant difference in interaction between treatment group and prespecified subgroups with respect to the composite of MCI and probable dementia. Conclusion In ambulatory adult patients ( 50 years of age) with hypertension but without diabetes or history of stroke who had an increased cardiovascular risk, intensive BP reduction was not superior to standard BP management with respect to the incidence of adjudicated probable dementia at a median follow-up of 5.11 years. Reference SPRINT MIND Investigators for the SPRINT Research Group, Williamson JD, Pajewski NM et al. Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia: A Randomized Clinical Trial. JAMA. 2019 Feb 12;321(6):553-561. Open reference URL https://web.pathway.md/studies/recDAGML8mqX75pXd 2/2