What BP agents other than ACE-I or ARB may be necessary for BP control in CKD patients?
Diuretics may be necessary for BP control, especially as CKD progresses and volume retention becomes more of an issue. However, few RCTs addressing hard cardiovascular or kidney outcomes have randomized patients to a diuretic versus another agent on top of an ACE-I or ARB. Therefore, in contrast to the other BP agents, we do not provide a guideline statement regarding diuretic use as a preferred second-line agent. The use of diuretics and other BP agents are discussed in more detail in Chapter 2.