What role can the measurement of natriuretic peptides play in the care of patients with advanced HF?
The measurement of natriuretic peptides such as BNP and NT-proBNP can be used to help assess the severity of heart failure symptoms and predict the risk of major adverse outcomes in patients treated with sacubitril/valsartan. Severe renal dysfunction can interfere with the interpretation of natriuretic peptide concentrations, and caution should be exercised when attempting to interpret BNP values in the context of ARNI treatment, as NT-proBNP measurement may be preferable in this setting.