What is the recommendation for hyperhomocysteinemia?
In patients with ischemic stroke or TIA with hyperhomocysteinemia, supplementation with folate, vitamin B6 , and vitamin B12 is not effective for preventing subsequent stroke. Challenges in understanding the relationship between vitamin supplementation and secondary stroke prevention stem from limitations in trial design, for example, including patients with both cardiovascular and enrollment from countries with varying levels of folate supplementation of foods.