6/28/23, 11:32 PM ICTOC Pathway Feedback Search Clinical Topics Home Studies ICTOC ICTOC Disease Disease Cellulitis Peripheral edema Trial question What is the role of leg compression therapy in patients with chronic edema of the leg and recurrent cellulitis? Study design Single center Open label RCT Population Characteristics of study participants 49.0% female N = 84 51.0% male 84 patients (41 female, 43 male) Inclusion criteria: patients with chronic edema of the leg and recurrent cellulitis Key exclusion criteria: younger than 18 years of age, already wearing effective compression garments 5 days per week, receiving end-of-life care, clinically unstable condition, chronic wound or a wound requiring specialist treatment, or compression therapy contraindicated Interventions N=41 compression (leg compression therapy plus education on cellulitis prevention) N=43 control (education alone) Primary outcome Recurrence of cellulitis 40.0 % 40 https://web.pathway.md/studies/recvWh46eEAzo4Jdi 1/2 6/28/23, 11:32 PM ICTOC Pathway 30.0 % 20.0 % 15 Significant decrease 10.0 % NNT = 4 0.0 % Compression Control Significant decrease in recurrence of cellulitis (15% vs. 40%; HR 0.23, 95% CI 0.09 to 0.59) Secondary outcomes No significant difference in hospitalization for cellulitis (7% vs. 14%; HR 0.38, 95% CI 0.09 to 1.59) Significant decrease in change in leg volume at 12 months (-181 ml vs. 60 ml; AD -241 ml, 95% CI -365 to -117) Significant decrease in combined quality-of-life measure for limb lymphedema (LYMQOL) at 12 months (-0.5 vs. -0.2; AD -0.3, 95% CI -0.6 to -0.1) Safety outcomes No significant difference in quality of life assessment. Conclusion In patients with chronic edema of the leg and recurrent cellulitis, compression was superior to control with respect to recurrence of cellulitis. Reference Elizabeth Webb, Teresa Neeman, Francis J Bowden et al. Compression Therapy to Prevent Recurrent Cellulitis of the Leg. N Engl J Med. 2020 Aug 13;383(7):630-639. Open reference URL https://web.pathway.md/studies/recvWh46eEAzo4Jdi 2/2