What were the results of the Women's Health Initiative randomized controlled trial?
The Women's Health Initiative randomized controlled trial found that there were both risks and benefits of conjugated equine estrogen plus progestin in healthy postmenopausal women. The principal results of the study were reported in the Journal of the American Medical Association in 2002 and found that the risks included a higher risk of stroke, heart attack, blood clots, and invasive breast cancer, while the benefits included a lower risk of colorectal cancer and bone fractures.