What is the optimal threshold for NT-proBNP in either people with HF and atrial fibrillation or HF and CKD?
Due to the lack of evidence regarding the optimal threshold for NT-proBNP in either people with HF and atrial fibrillation or HF and CKD the committee agreed that further research in this area would be beneficial for future updates of this guideline. In addition to this the committee agreed that a large study was needed to provide more certainty with regards to which NT-proBNP threshold (400pg/ml or 125pg/ml) is more clinically and cost effective for the diagnosis of HF in people with suspected HF would also be of benefit for future guideline updates due to the limitations of current diagnostic accuracy studies. The committee agreed that the 400pg/ml and 125pg/ml thresholds would be of most interest as these are the two thresholds used in practice.