What is the role of statins in primary prevention of cardiovascular events and mortality in older men?
Statins are recommended for primary prevention of cardiovascular events and mortality in older men. Several meta-analyses have found that statins reduce the risk of cardiovascular events and mortality in older men without established cardiovascular disease. Other studies have found that statins can improve risk assessment beyond what is recommended by the European Society of Cardiology (ESC) and American Heart Association/American College of Cardiology (AHA/ACC) primary prevention guidelines when combined with coronary artery calcium (CAC) score assessment. Furthermore, a simple disease-guided approach to personalize statin allocation in elderly people has been proposed. However, further research is needed to better understand the role of statins in this population.  