6/29/23, 11:45 PM SPRINT Pathway Feedback Search Clinical Topics Home Studies SPRINT SPRINT Disease Hypertension Trial question What is the role of intensive BP control in nondiabetic hypertensive patients who are at an increased cardiovascular risk? Study design Multi-center Open label RCT Population Characteristics of study participants 36.0% female N = 9361 64.0% male 9361 patients (3332 female, 6029 male) Inclusion criteria: patients with a systolic BP 130 mmHg and an increased cardiovascular risk, but without diabetes Key exclusion criteria: diabetes mellitus, prior stroke, or CKD Interventions N=4678 intensive BP reduction (systolic blood-pressure target of < 120 mmHg) N=4683 standard BP management (systolic blood-pressure target of < 140 mmHg) Primary outcome https://web.pathway.md/studies/recAHD1gOju2thSrB 1/2 6/29/23, 11:45 PM SPRINT Pathway Myocardial infarction, other acute coronary syndromes, stroke, heart failure, or death from cardiovascular causes 6.8 % 6.8 5.2 5.1 % 3.4 % Significant decrease 1.7 % NNT = 63 0.0 % Intensive blood pressure reduction Standard blood pressure management Significant decrease in myocardial infarction, other acute coronary syndromes, stroke, HF, or death from cardiovascular causes (5.2% vs. 6.8%; HR 0.75, 95% CI 0.64 to 0.89) Secondary outcomes Significant decrease in death from any cause (3.3% vs. 4.5%; HR 0.73, 95% CI 0.6 to 0.9) Safety outcomes No significant differences in serious adverse events (38.3% vs. 37.1%, p=0.25). Significant differences in serious adverse events as possibly or definitely related to the intervention (4.7% vs. 2.5%, p < 0.001), hypotension (2.4% vs. 1.4%, p = 0.001), and AKI or acute renal failure (4.1% vs. 2.5%, p < 0.001). Conclusion In patients with a systolic BP 130 mmHg and an increased cardiovascular risk, but without diabetes, intensive BP reduction was superior to standard BP management with respect to myocardial infarction, other acute coronary syndromes, stroke, HF, or death from cardiovascular causes. Reference SPRINT Research Group, Wright JT Jr, Williamson JD et al. A Randomized Trial of Intensive versus Standard Blood-Pressure Control. N Engl J Med. 2015 Nov 26;373(22):2103-16. Open reference URL https://web.pathway.md/studies/recAHD1gOju2thSrB 2/2