References 1. Alvar Agusti, Richard Beasley, Bartolome R. Celli et al. Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease: 2023 Report. GOLD. 2023. Open 2. Qaseem A, Wilt TJ, Weinberger SE et al. Diagnosis and management of stable chronic obstructive pulmonary disease: a clinical practice guideline update from the American College of Physicians, American College of Chest Physicians, American Thoracic Society, and European Respiratory Society. Ann Intern Med. 2011 Aug 2;155 3 179 91. Open 3. US Preventive Services Task Force USPSTF , Siu AL, Bibbins-Domingo K et al. Screening USPSTF for Chronic Obstructive Pulmonary Disease: US Preventive Services Task Force Recommendation Statement. JAMA. 2016 Apr 5;315 13 1372 7. Open 4. O'Donnell DE, Aaron S, Bourbeau J et al. VA/DoD clinical practice guideline for the management of chronic obstructive pulmonary disease. VA/DoD. 2021 Apr;Version 3.0. Open 5. Wedzicha JA Ers Co-Chair, Miravitlles M, Hurst JR et al. Management of COPD exacerbations: a European Respiratory Society/American Thoracic Society guideline. Eur Respir J. 2017 Mar 15;49 3 . Open 6. Bourbeau J, Bhutani M, Hernandez P et al. Canadian Thoracic Society Clinical Practice Guideline on pharmacotherapy in patients with COPD 2019 update of evidence. Can J Resp Crit Care Sleep Med. 2019 Oct;3 4 210 232. Open 7. David Smith, Ingrid Du Rand, Charlotte Louise Addy et al. British Thoracic Society guideline for the use of long-term macrolides in adults with respiratory disease. Thorax. 2020 May;75 5 370 404. Open 8. Darcy D Marciniuk, Donna Goodridge, Paul Hernandez et al. Managing dyspnea in patients with advanced chronic obstructive pulmonary disease: a Canadian Thoracic Society clinical practice guideline. Can Respir J. 2011 Mar-Apr;18 2 69 78. Open 9. Marc Miravitlles, Asger Dirksen, Ilaria Ferrarotti et al. European Respiratory Society statement: diagnosis and treatment of pulmonary disease in 1 antitrypsin deficiency. Eur Respir J. 2017 Nov 30;50 5 1700610. Open 10. Weill D, Benden C, Corris PA et al. A consensus document for the selection of lung transplant candidates: 2014 an update from the Pulmonary Transplantation Council of the International Society for Heart and Lung Transplantation. J Heart Lung Transplant. 2015 Jan;34 1 1 15. Open 11. Linda Nici, Manoj J Mammen, Edward Charbek et al. Pharmacologic Management of Chronic Obstructive Pulmonary Disease. An Official American Thoracic Society Clinical Practice Guideline. Am J Respir Crit Care Med. 2020 May 1;201 9):e56-e69. Open 12. Jadwiga A Wedzicha, Peter M A Calverley, Richard K Albert et al. Prevention of COPD exacerbations: a European Respiratory Society/American Thoracic Society guideline. Eur Respir J. 2017 Sep https://web.pathway.md/diseases/recAhwo46uP9QXlBg 16/18 6/23/23, 3:26 AM Chronic obstructive pulmonary disease Pathway 9;50 3 1602265. Open 13. Robert A Sandhaus, Gerard Turino, Mark L Brantly et al. The Diagnosis and Management of Alpha-1 Antitrypsin Deficiency in the Adult. Chronic Obstr Pulm Dis. 2016 Jun 6;3 3 668 682. Open 14. Jeremy E Orr, John M Coleman rd, Jakob I McSparron et al. Summary for Clinicians: Clinical Practice Guideline for Long-Term Noninvasive Ventilation in Chronic Stable Hypercapnic Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc. 2021 Mar;18 3 395 398. Open 15. Darcy D Marciniuk, P Hernandez, M Balter et al. Alpha-1 antitrypsin deficiency targeted testing and augmentation therapy: a Canadian Thoracic Society clinical practice guideline. Can Respir J. 2012 Mar- Apr;19 2 109 16. Open 16. Riley CM, Sciurba FC. Diagnosis and Outpatient Management of Chronic Obstructive Pulmonary Disease: A Review. JAMA. 2019 Feb 26;321 8 786 797. Open 17. Rabe KF, Watz H. Chronic obstructive pulmonary disease. Lancet. 2017 May 13;389 10082 1931 1940. Open 18. Ringbaek T, Seersholm N, Viskum K. Standardised mortality rates in females and males with COPD and asthma. Eur Respir J. 2005 May;25 5 891 5. Open 19. Global Initiative for Chronic Obstructive Lung Disease. Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2018 Report. GOLD. 2018. Open 20. Balter MS, La Forge J, Low DE et al. Canadian guidelines for the management of acute exacerbations of chronic bronchitis. Can Respir J. 2003 Jul-Aug;10 Suppl B 3B 32B. Open 21. Dunn B. Updated guidelines for chronic obstructive pulmonary disease. JAAPA. 2019 Jan;32 1 49 51. Open 22. Strickland SL, Rubin BK, Drescher GS et al. AARC clinical practice guideline: effectiveness of nonpharmacologic airway clearance therapies in hospitalized patients. Respir Care. 2013 Dec;58 12 2187 93. Open 23. Strickland SL, Rubin BK, Haas CF et al. AARC Clinical Practice Guideline: Effectiveness of Pharmacologic Airway Clearance Therapies in Hospitalized Patients. Respir Care. 2015 Jul;60 7 1071 7. Open 24. Jessica Evans, Yue Chen, Pat G Camp et al. Estimating the prevalence of COPD in Canada: Reported diagnosis versus measured airflow obstruction. Health Rep. 2014 Mar;25 3 3 11. Open 25. Jos Luis L pez-Campos, Wan Tan, Joan B Soriano. Global burden of COPD. Respirology. 2016 Jan;21 1 14 23. Open 26. Fanny W Ko, Ka Pang Chan, David S Hui et al. Acute exacerbation of COPD. Respirology. 2016 Oct;21 7 1152 65. Open 27. Patrick Mulhall, Gerard Criner. Non-pharmacological treatments for COPD. Respirology. 2016 Jul;21 5 791 809. Open 28. Michael Dreher, Pierre-Charles Neuzeret, Wolfram Windisch et al. Prevalence Of Chronic Hypercapnia In Severe Chronic Obstructive Pulmonary Disease: Data From The HOmeVent Registry. 2019 Oct 18;14 2377 2384.2019 Oct 18;14 2377 2384. Open 29. Christophe Faisy, Ferhat Meziani, Benjamin Planquette et al. Effect of Acetazolamide vs Placebo on Duration of Invasive Mechanical Ventilation Among Patients With Chronic Obstructive Pulmonary Disease: https://web.pathway.md/diseases/recAhwo46uP9QXlBg 17/18 6/23/23, 3:26 AM Chronic obstructive pulmonary disease Pathway A Randomized Clinical Trial. JAMA. 2016 Feb 2;315 5 480 8. Open 30. Rachael A Lee, Robert M Centor, Linda L Humphrey et al. Appropriate Use of Short-Course Antibiotics in Common Infections: Best Practice Advice From the American College of Physicians. Ann Intern Med. 2021 Apr 6. Open 31. C G Cote, V M Pinto-Plata, J M Marin et al. The modified BODE index: validation with mortality in COPD. Eur Respir J. 2008 Nov;32 5 1269 74. Open 32. Manuela Karloh, Anamaria Fleig Mayer, Rosemeri Maurici et al. The COPD Assessment Test: What Do We Know So Far? A Systematic Review and Meta-Analysis About Clinical Outcomes Prediction and Classification of Patients Into GOLD Stages. Chest. 2016 Feb;149 2 413 425. Open 33. Qiangru Huang, Chengying He, Huaiyu Xiong et al. DECAF score as a mortality predictor for acute exacerbation of chronic obstructive pulmonary disease: a systematic review and meta-analysis. BMJ Open. 2020 Oct 30;10 10):e037923. Open 34. Ian G. Stiell, MD MSc, Jeffrey J. Perry et al. Clinical validation of a risk scale for serious outcomes among patients with chronic obstructive pulmonary disease managed in the emergency department. CMAJ. 2018 Dec 3; 190 48 E1406 E1413. Open 35. Federico P G mez, Roberto Rodriguez-Roisin. Global Initiative for Chronic Obstructive Lung Disease GOLD guidelines for chronic obstructive pulmonary disease. Curr Opin Pulm Med. 2002 Mar;8 2 81 6. Open 36. Bartolome R Celli, Claudia G Cote, Jose M Marin et al. The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease. N Engl J Med. 2004 Mar 4;350 10 1005 12. Open 37. Paul W Jones, Margaret Tabberer, Wen-Hung Chen. Creating scenarios of the impact of COPD and their relationship to COPD Assessment Test CAT ) scores. BMC Pulm Med. 2011 Aug 11;11 42. Open 38. C Echevarria, J Steer, K Heslop-Marshall et al. Validation of the DECAF score to predict hospital mortality in acute exacerbations of COPD. Thorax. 2016 Feb;71 2 133 40. Open 39. J rg D Leuppi, Philipp Schuetz, Roland Bingisser et al. Short-term vs conventional glucocorticoid therapy in acute exacerbations of chronic obstructive pulmonary disease: the REDUCE randomized clinical trial. JAMA. 2013 Jun 5;309 21 2223 31. Open 40. Jingen Xia, Sichao Gu, Wei Lei et al. High-flow nasal cannula versus conventional oxygen therapy in acute COPD exacerbation with mild hypercapnia: a multicenter randomized controlled trial. Crit Care. 2022 Apr 15;26 1 109. Open 41. Magnus Ekstr m, Diana Ferreira, Sungwon Chang et al. Effect of Regular, Low-Dose, Extended-release Morphine on Chronic Breathlessness in Chronic Obstructive Pulmonary Disease: The BEAMS Randomized Clinical Trial. JAMA. 2022 Nov 22;328 20 2022 2032. Open 42. Mark A Malesker, Priscilla Callahan-Lyon, J Mark Madison et al. Chronic Cough Due to Stable Chronic Bronchitis: CHEST Expert Panel Report. Chest. 2020 Aug;158 2 705 718. Open 43. Surya P Bhatt, Klaus F Rabe, Nicola A Hanania et al. Dupilumab for COPD with Type 2 Inflammation Indicated by Eosinophil Counts. N Engl J Med. 2023 May 21. Online ahead of print. Open https://web.pathway.md/diseases/recAhwo46uP9QXlBg 18/18