6/28/23, 11:32 PM ICU-diary Pathway Feedback Search Clinical Topics Home Studies ICU-diary ICU-diary Disease Posttraumatic stress disorder Trial question What is the effect of an ICU diary on posttraumatic stress disorder symptoms among patients receiving mechanical ventilation? Study design Multi-center Open label RCT Population Characteristics of study participants 37.3% female N = 657 62.7% male 657 patients (126 female, 213 male) Inclusion criteria: adult patients (with 1 family member each) who received mechanical ventilation within 48 hours after ICU admission for at least 2 days Key exclusion criteria: no family members visitation, a preadmission diagnosis of psychosis or dementia, acute neurologic diseases, cardiac arrest at admission, mute or deaf, moribund or imminent death Interventions N=355 intervention (an ICU diary filled in by clinicians and family members) N=354 control (usual ICU care without an ICU diary) Primary outcome Significant posttraumatic stress disorder symptoms 34.3 % 34.3 https://web.pathway.md/studies/recPqFhCDfBDQb7hQ 1/2 6/28/23, 11:32 PM ICU-diary Pathway 29.9 25.7 % 17.1 % 8.6 % No significant difference 0.0 % Intervention Control No significant difference in significant posttraumatic stress disorder symptoms (29.9% vs. 34.3%; ARD -4, 95% CI -15 to 6) Secondary outcomes No significant difference in Impact of Event Scale-Revised score (12 vs. 13; AD -1.47, 95% CI -1.93 to 4.87) No significant difference in Hospital Anxiety Depression Scale score among patients at 3- month follow-up (9 vs. 9; AD -0.75, 95% CI -2.27 to 0.78) No significant difference in Hospital Anxiety Depression Scale score among families at 3- month follow-up (14 vs. 14; AD 0.33, 95% CI -0.96 to 1.63) Safety outcomes No significant differences in symptoms of anxiety and depression, memories of ICU stay, delusional memories, emotional memories. Conclusion In adult patients (with 1 family member each) who received mechanical ventilation within 48 hours after ICU admission for at least 2 days, intervention was not superior to control with respect to significant posttraumatic stress disorder symptoms. Reference Mait Garrouste-Orgeas, C cile Flahault, Isabelle Vinatier et al. Effect of an ICU Diary on Posttraumatic Stress Disorder Symptoms Among Patients Receiving Mechanical Ventilation: A Randomized Clinical Trial. JAMA. 2019 Jul 16;322(3):229-239. Open reference URL https://web.pathway.md/studies/recPqFhCDfBDQb7hQ 2/2