What is the best way to manage bleeding on a NOAC?
The best way to manage bleeding on a NOAC is to minimize the risk of bleeding. This can be done by selecting the right dose of the NOAC and following dose reduction criteria to avoid increased drug exposure (primarily due to impaired renal function). Additionally, a helpful framework to consider when managing NOAC-related bleeding includes: (1) prevention of bleeding, (2) general principles and supportive measures, (3) nonspecific hemostatic agents, and (4) NOAC-specific reversal.