What is the effect of intensive blood pressure control on clinical outcomes in patients with diabetes and chronic kidney disease?
Post hoc analyses of data from ACCORD, SPRINT, AASK and MDRD have found that intensive blood pressure control can provide cardiovascular benefits, including a reduction in mortality, in patients with diabetes and chronic kidney disease. However, the effects of intensive blood pressure control on cardiovascular outcomes may be modulated by glycemic control. As such, the evidence is indirect, diminishing the certainty of the benefits and strength of recommendation of targeting systolic blood pressure <120 mm Hg.