What are the recommendations for TCD screening of adults with SCD?
At present, there are no validated TCD criteria for predicting stroke in adults with SCD. The National Institutes of Health and the American Academy of Pediatrics recommend annual TCD screening from 2 to 16 years of age.560,561 Few studies have been done to determine whether TCD also predicts stroke in adults with SCD. One study comparing TCD velocities in SCD adults with those of healthy control subjects found that velocities in SCD adults were lower than those found in children, higher than in healthy control sub- jects, and negatively correlated with the hematocrit in both Another study found no examples of high TCD (>200 cm/s) in adults with SCD. The mean velocity was 110 cm/s, which is higher than in normal adults but lower than in children with SCD.563