What are the age-related mechanisms that interact with mechanisms underlying CKD progression?
Age-related mechanisms such as fibrosis and cellular senescence are known to interact with mechanisms underlying CKD progression. Fibrosis is the formation of excess connective tissue in the body, while cellular senescence is the process of cells losing their ability to divide and reproduce. These age-related mechanisms can contribute to the progression of CKD by altering vascular biology and causing structural changes in the kidney. Additionally, age-related factors such as AKI can also increase the risk of CKD progression.  