What is the role of B-type natriuretic peptide (BNP) and NT-proBNP in the diagnosis and prognostication of HFrEF?
B-type natriuretic peptide (BNP) and NT-proBNP are the most studied biomarkers in HF and they play a role in diagnosis and prognostication. Higher concentrations of BNP or NT-proBNP in an ambulatory patient with HFrEF inform high risk, particularly when the concentrations are rising. Current clinical practice guidelines give a Class I recommendation to measure BNP or NT-proBNP to support a clinical diagnosis of HF, assess disease severity, or establish prognosis.