6/30/23, 12:10 AM VADT Pathway Feedback Search Clinical Topics Home Studies VADT VADT Disease Diabetes mellitus type 2 Trial question What is the role of intensive glucose control in patients with poorly controlled T2DM? Study design Multi-center Open label RCT Population Characteristics of study participants 3.0% female N = 1791 97.0% male 1791 patients (52 female, 1739 male) Inclusion criteria: military veterans (mean age, 60.4 years) who had a suboptimal response to therapy for T2DM Key exclusion criteria: glycated Hgb level < 7.5%, occurrence of a cardiovascular event during the previous 6 months, advanced congestive HF, severe angina, a life expectancy < 7 years, or body-mass index > 40 Interventions N=892 intensive therapy (target to achieve a glycated Hgb level of < 6%) N=899 standard therapy (target to achieve a glycated Hgb level of < 9%) Primary outcome Cardiovascular events 264.0 264 235 198 0 https://web.pathway.md/studies/recU1I04ktsJG1b6v 1/2 6/30/23, 12:10 AM 198.0 VADT Pathway 132.0 66.0 No significant difference 0.0 Intensive therapy Standard therapy No significant difference in cardiovascular events (235 vs. 264; HR 0.88, 95% CI 0.74 to 1.05) Secondary outcomes No significant difference in death from any cause (102 vs. 95; HR 1.07, 95% CI 0.81 to 1.42) Safety outcomes Significant differences in serious adverse events (24.1% vs. 17.6%, p = 0.05), including dyspnea (p = 0.006). Conclusion In military veterans (mean age, 60.4 years) who had a suboptimal response to therapy for T2DM, intensive therapy was not superior to standard therapy with respect to cardiovascular events. Reference Duckworth W, Abraira C, Moritz T et al. Glucose control and vascular complications in veterans with type 2 diabetes. N Engl J Med. 2009 Jan 8;360(2):129-39. Open reference URL https://web.pathway.md/studies/recU1I04ktsJG1b6v 2/2