What safety concerns have previously been associated with multivessel primary PCI?
Previous clinical practice guidelines have recommended against PCI of nonculprit artery stenoses at the time of primary PCI in hemodynamically stable patients with STEMI due to safety concerns, which included increased risks for procedural complications, longer procedural time, contrast nephropathy, and stent thrombosis in a prothrombotic and proinflammatory state (9,10), and in part on the findings from many observational studies and meta-analyses of trends toward or statistically significant worse outcomes in those who underwent multivessel primary PCI (12 16,21 23).