What is the hierarchy of outcomes for CKD studies?
The hierarchy of outcomes for CKD studies is Mortality, cardiovascular mortality, cardiovascular events, kidney failure, composite including clinical events of critical importance; Doubling of SCr or halving of GFR, and proteinuria (categorical) of high importance; Kidney function (continuous), and urine protein level (continuous) of moderate importance; and Adverse events: drug discontinuation or dose decrease, hyperkalemia, early rise of SCr or decrease of GFR of importance dependent on severity. GFR stands for glomerular filtration rate and SCr stands for serum creatinine.