What are the benefits of taking ACE inhibitors for patients with HFrEF?
ACE inhibitors have been shown in large RCTs to reduce morbidity and mortality in patients with HFrEF with mild, moderate, or severe symptoms of HF, with or without coronary artery disease.128 133 Data suggest that there are no differences among available ACE inhibitors in their effects on symptoms or survival. ACE inhibitors should be started at low doses and titrated upward to doses shown to reduce the risk of cardiovascular events in clinical trials. Angioedema occurs in <1% of patients who take an ACE inhibitor, but it occurs more frequently in blacks and women.