What evidence is there that tight glycemic control reduces risk of stroke in patients with diabetes mellitus?
Despite the lack of convincing support from any individual clinical trial for intensified glycemic control to reduce stroke incidence in patients with diabetes mellitus, a recent meta-analysis provided some supportive evidence in a subgroup of patients with diabetes mellitus. From 649 identified studies, the authors identified 9 relevant trials, which provided data Overall, intensive control of glucose compared with usual care had no effect however, in a stratified analyses, a beneficial effect was seen in patients with diabetes mellitus and a BMI >30 kg/m2 (RR, 0.86; 95% CI, 0.75 0.99; P=0.041).