6/28/23, 11:08 PM HandiCAP Pathway Feedback Search Clinical Topics Home Studies HandiCAP HandiCAP Trial question What is the effect of intraoperative handovers of anesthesia care in adults undergoing extended surgical procedures? Study design Multi-center Single blinded RCT Population Characteristics of study participants 44.0% female N = 1772 56.0% male 1772 patients (775 female, 997 male) Inclusion criteria: adult patients scheduled for major inpatient surgery expected to last at least 2 hours Key exclusion criteria: pregnancy; previous surgery by the same specialty within 6 months; participation in another interventional trial within the last 3 months Interventions N=891 handover of care (at least one complete transition of care from 1 anesthesiologist to another during surgery) N=881 no handover of care (same anesthesiologist from anesthesia induction to end of surgical procedure) Primary outcome Composite of death, hospital readmission, or serious postoperative complications at day 30 32.5 % 32.5 30.1 24.4 % 16.3 % 8.1 % No significant difference 0.0 % https://web.pathway.md/studies/recJu1uio1YZxxxnK 1/2 6/28/23, 11:08 PM HandiCAP Pathway 0 0 % Handover of care No handover of care No significant difference in composite of death, hospital readmission, or serious postoperative complications at day 30 (30.1% vs. 32.5%; OR 0.89, 95% CI 0.72 to 1.1) Secondary outcomes No significant difference in death from all causes at day 30 (2.1% vs. 3.4%; OR 0.61, 95% CI 0.34 to 1.1) No significant difference in hospital readmission at day 30 (13% vs. 15.6%; OR 0.8, 95% CI 0.61 to 1.05) No significant difference in the rate of serious postoperative complications within 30 days (21.9% vs. 21.6%; OR 1.02, 95% CI 0.81 to 1.28) Conclusion In adult patients scheduled for major inpatient surgery expected to last at least 2 hours, handover of care was not superior to no handover of care with respect to the composite of death, hospital readmission, or serious postoperative complications at day 30. Reference Melanie Meersch, Raphael Weiss, Mira K llmar et al. Effect of Intraoperative Handovers of Anesthesia Care on Mortality, Readmission, or Postoperative Complications Among Adults: The HandiCAP Randomized Clinical Trial. JAMA. 2022 Jun 28;327(24):2403-2412. Open reference URL https://web.pathway.md/studies/recJu1uio1YZxxxnK 2/2