What is the risk of thrombosis in antiphospholipid syndrome patients treated with direct oral anticoagulants?
A meta-analysis of international patient-level data has shown that there is an increased risk of thrombosis in antiphospholipid syndrome patients treated with direct oral anticoagulants as compared to those treated with vitamin K antagonists. This finding was reported in a study by Dufrost et al. (2019) published in the journal Autoimmun Rev. The study concluded that more research is needed to understand the mechanisms underlying this increased risk and to develop strategies to mitigate it.