What are the limitations of predictive models derived from university medical centers?
The predictive models derived from university medical centers tend to overestimate the likelihood of IHD in patients at lower risk. Additionally, these models were derived from populations of patients #70 years of age, meaning they may not be as accurate for other age groups. A key limitation of these predictive models is that they do not incorporate data about risk factors into the probability estimate, unlike the Duke Databank for Cardiovascular Disease which does. Furthermore, any adjustments made to these models to correct referral bias are subject to error if the prevalence estimates used are flawed.