What evidence was found in the meta-analysis of 21 RCTs by Xie et al.?
The meta-analysis of 21 RCTs by Xie et al. concluded that the absolute benefits of lowering SBP were greater and the number-needed-to-treat was smaller in trials where all enrolled patients had vascular disease, diabetes, or kidney disease. On-treatment BP averaged 133/76 mm Hg on intensive treatment and 140/81 mm Hg on less-intensive treatment. Outcomes in patients with and without albuminuria at baseline were not reported separately.