What is the potential harm of achieving lower targets in subgroup of older adults with CKD?
There was no description of potential harm of achieving lower targets in this subgroup of older adults with CKD, although the risk benefit ratio in the entire CKD cohort and in the entire subcohort older than 75 years in SPRINT was favorable. Even in the age group 80 years and older, subgroup analysis in SPRINT showed that intensive BP lowering decreased the risk of CV events (HR: 0.66; 95% CI: 0.48-0.91).