What are the effects of ACE inhibitors on renal function and hyperkalemia?
For the outcomes of renal function (n=967) and hyperkalemia (n=970) there was no clinical effect of ACE inhibitors. With high dose versus low dose ACE inhibitors all of the outcomes were again rated as very low quality. The outcomes of renal dysfunction or hyperkalaemia (associated with wide confidence intervals around the effect estimate) and hypotension/dizziness all suggested a clinically important increase in events with high dose ACE inhibitors (n=988).