What was the eligibility requirement for the trial?
The eligibility requirement for the WAKE-UP trial was MRI mismatch between abnormal signal on DW-MRI and no visible signal change on FLAIR. Exclusions included DW-MRI lesions larger than one-third of the territory of the middle cerebral artery (MCA), NIHSS score >25, contraindication to treatment with alteplase, or planned thrombectomy.