6/28/23, 11:42 PM iDIAPASON Pathway Feedback Search Clinical Topics Home Studies iDIAPASON iDIAPASON Disease Ventilator-associated pneumonia Trial question Is short duration of antibiotic therapy noninferior to prolonged antibiotic therapy in patients with P. aeruginosa ventilator-associated pneumonia? Study design Multi-center Open label RCT Population Characteristics of study participants 24.0% female N = 186 76.0% male 186 patients (45 female, 141 male) Inclusion criteria: adult patients with P. aeruginosa ventilator-associated pneumonia Key exclusion criteria: current antibiotic therapy active on P. aeruginosa for extra-pulmonary infection; chronic pulmonary colonization with P. aeruginosa; immunosuppression Interventions N=88 short-duration therapy (antibiotic treatment for 8 days) N=98 long-duration therapy (antibiotic treatment for 15 days) Primary outcome Composite outcome of death and recurrence in intensive care unit at day 90 35.2 % 35.2 26.4 % 25.5 https://web.pathway.md/studies/recyJY8M0sjfCxpz5 1/2 6/28/23, 11:42 PM iDIAPASON Pathway 17.6 % Difference not exceeding nonferiority margin 8.8 % 0.0 % Short-duration therapy Long-duration therapy Difference not exceeding nonferiority margin in composite outcome of death and recurrence in the ICU at day 90 (35.2% vs. 25.5%; AD 9.7%, 90% CI 0 to 21.2) Secondary outcomes Borderline significant increase in recurrence in the ICU at day 90 (17% vs. 9.2%; AD 7.9%, 90% CI 0 to 16.8) No significant difference in duration of mechanical ventilation (22 days vs. 25 days; AD -3 days, 95% CI -9 to 5) Conclusion In adult patients with P. aeruginosa ventilator-associated pneumonia, short-duration therapy was noninferior to long-duration therapy with respect to the composite outcome of death and recurrence in the ICU at day 90. Reference Adrien Bougl , Sophie Tuffet, Laura Federici et al. Comparison of 8 versus 15 days of antibiotic therapy for Pseudomonas aeruginosa ventilator-associated pneumonia in adults: a randomized, controlled, open-label trial. Intensive Care Med. 2022 Jul;48(7):841-849. Open reference URL https://web.pathway.md/studies/recyJY8M0sjfCxpz5 2/2