what are the Recommendations for Primary Severe Hypercholesterolemia
(LDL-C ≥190 mg/dL [≥4.9 mmol/L])
Referenced studies that support recommendations are summarized
in Online Data Supplements 9 and 10.?
In patients 20 to 75 years of age with a baseline LDL-C level of 190 mg/dL or higher (?4.9 mmol/L), who achieve less than a 50% reduction in LDL-C levels and have fasting triglycerides 300 mg/dL or lower (?3.4 mmol/L), while taking maximally tolerated statin and ezetimibe therapy, the addition of a bile acid sequestrant may be considered.S