Increase the dose of LMWH by about one-quarter to one-third in patients with recurrent VTE while on long-term LMWH deemed to be compliant with treatment. B Clinical findings Symptoms Past medical history Buttock pain Antiphospholipid syndrome https://web.pathway.md/diseases/recy7Y18EJ5OGaopy 13/17 6/29/23, 10:06 PM Deep vein thrombosis Pathway Calf pain Beh et's syndrome Fever Celiac disease Groin pain FVL mutation Leg cramping Granulomatosis with polyangiitis Leg pain IBD Leg swelling Immobility Inserted central venous catheter Medication history Malignancy Obesity Hormonal contraceptives PE Past surgical history Protein C deficiency Protein S deficiency Recent surgery Prothrombin G20210A mutation Rheumatoid arthritis Vital signs Superficial vein thrombosis Tachycardia Thromboangiitis obliterans Integument exam Past obstetric history Leg discoloration Pregnancy Leg telangiectasia Social history Tobacco use Vascular exam Bancroft's sign Homans' sign Leg edema Lisker's sign Louvel's sign Lowenberg's sign Peabody's sign Pratt's sign Rose's sign Lab findings serum D dimer Studies 2019 PREVENT In adults patients within 48 hours after admission to an ICU, pneumatic compression was not superior to control with respect to incident proximal deep vein thrombosis. Yaseen M Arabi et al. N Engl J Med. 2019 Apr 4. 2019 AVERT https://web.pathway.md/diseases/recy7Y18EJ5OGaopy 14/17 6/29/23, 10:06 PM Deep vein thrombosis Pathway In ambulatory patients with cancer who were at intermediate-to-high risk for VTE and were initiating chemotherapy, apixaban was superior to placebo with respect to the rate of VTE within 180 days. Carrier M et al. N Engl J Med. 2019 Feb 21. Show 22 more References 1. Saskia Middeldorp, Robby Nieuwlaat, Lisa Baumann Kreuziger et al. American Society of Hematology 2023 Guidelines for Management of Venous Thromboembolism: Thrombophilia Testing. Blood Adv. 2023 May 17;bloodadvances.2023010177. Open 2. Kathryn P Trayes, James S Studdiford, Sarah Pickle et al. Edema: Diagnosis and Management. Am Fam Physician. 2013 Jul 15;88 2 102 10. Open 3. Stavros K Kakkos, Manjit Gohel, Niels Baekgaard et al. Editor's Choice European Society for Vascular Surgery ESVS 2021 Clinical Practice Guidelines on the Management of Venous Thrombosis. 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