What are the effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy?
The effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy have been studied by the Heart Outcomes Prevention Evaluation Study Investigators. According to their research, losartan was found to reduce the risk of stroke, and reduce the risk of doubling of serum creatinine, and end stage renal disease. Additionally, losartan was also found to reduce the risk of death from cardiovascular causes, myocardial infarction, and hospitalization due to heart failure. (Brenner BM, Cooper ME, de Zeeuw D, et al. Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med. 2001;345:861 869).  