6/28/23, 11:41 PM iCBT (secondary analysis, guided iCBT vs. usual treatment) Pathway Feedback Search Clinical Topics Home Studies iCBT (secondary analysis, guided iCBT vs. usual treatment) iCBT (secondary analysis, guided iCBT vs. usual treatment) Disease Disease Generalized anxiety disorder Major depressive disorder Trial question What is the effect of clinician-guided iCBT on university students with anxiety and depression? Study design Multi-center Open label RCT Population 880 patients Inclusion criteria: university students with anxiety and/or depression Key exclusion criteria: positive screens for lifetime bipolar disorder or nonaffective psychosis or recent suicidal ideation with intent Interventions N=445 clinician-guided iCBT (guides sent online weekly messages to users designed to create personalized experiences and provide feedback) N=435 treatment as usual (informal counseling services provided by the faculty or referrals to the clinic) Primary outcome Joint remission of anxiety and depression at 3 months 51.8 % 51.8 40 38.8 % 25.9 % Significant increase 12.9 % NNT = 8 0.0 % Clinician-guided internet-delivered cognitive behavioral therapy Treatment as usual https://web.pathway.md/studies/recRQt42kgHzbNItQ 1/2 6/28/23, 11:41 PM iCBT (secondary analysis, guided iCBT vs. usual treatment) Pathway Significant increase in joint remission of anxiety and depression at 3 months (51.8% vs. 40%; AD 11.8%, 95% CI 4.8 to 18.8) Secondary outcomes No significant difference in anxiety remission (62.7% vs. 53%; AD 9.7%, 95% CI -6.73 to 26.13) Conclusion In university students with anxiety and/or depression, clinician-guided iCBT was superior to treatment as usual with respect to joint remission of anxiety and depression at 3 months. Reference Corina Benjet, Nur Hani Zainal, Yesica Albor et al. A Precision Treatment Model for Internet- Delivered Cognitive Behavioral Therapy for Anxiety and Depression Among University Students: A Secondary Analysis of a Randomized Clinical Trial. JAMA Psychiatry. 2023 Jun 7;e231675. Online ahead of print. Open reference URL https://web.pathway.md/studies/recRQt42kgHzbNItQ 2/2