What is the effect of reduced renal function on time in therapeutic range among anticoagulated atrial fibrillation patients?
An observational cohort study conducted by Bonde et al. (2017) found that reduced renal function was associated with a lower time in therapeutic range among anticoagulated atrial fibrillation patients. The study showed that patients with creatinine clearance lower than 60 ml/min had a lower time in therapeutic range compared to those with creatinine clearance greater than 60 ml/min. This suggests that renal function should be monitored closely in anticoagulated atrial fibrillation patients to ensure that they are receiving the optimal dose of anticoagulation therapy.