6/28/23, 1:16 AM DETO2X-AMI Pathway Feedback Search Clinical Topics Home Studies DETO2X AMI DETO2X AMI Disease Disease Non-ST-elevation myocardial inf ST-elevation myocardial infarction Trial question What is the effect of routine oxygen therapy in patients with suspected acute myocardial infarction who do not have hypoxemia at baseline? Study design Multi-center Open label RCT Population Characteristics of study participants 31.0% female N = 6629 69.0% male 6629 patients (2023 female, 4606 male) Inclusion criteria: patients with suspected acute myocardial infarction and an oxygen saturation of 90% on pulse oximetry Key exclusion criteria: patients receiving ongoing oxygen therapy, presenting with cardiac arrest or had a cardiac arrest between presentation and enrollment Interventions N=3311 oxygen therapy (supplemental oxygen at 6 L/min for 6-12 hours through an open face mask) N=3318 no supplemental oxygen https://web.pathway.md/studies/rec2LwjWH5KrZfWZR 1/2 6/28/23, 1:16 AM DETO2X-AMI Pathway Primary outcome All-cause death at 1 year 5.1 % 5.1 5 3.8 % 2.5 % 1.3 % No significant difference 0.0 % Oxygen therapy No supplemental oxygen No significant difference in all-cause death at 1 year (5% vs. 5.1%; HR 0.97, 95% CI 0.79 to 1.21) Secondary outcomes No significant difference in the rate of rehospitalization with myocardial infarction within 1 year (3.8% vs. 3.3%; HR 1.13, 95% CI 0.88 to 1.46) Conclusion In patients with suspected acute myocardial infarction and an oxygen saturation of 90% on pulse oximetry, oxygen therapy was not superior to no supplemental oxygen with respect to a all-cause death at 1 year. Reference Hofmann R, James SK, Jernberg T et al. Oxygen Therapy in Suspected Acute Myocardial Infarction. N Engl J Med. 2017 Sep 28;377(13):1240-1249. Open reference URL https://web.pathway.md/studies/rec2LwjWH5KrZfWZR 2/2