What are the effects of spironolactone on type 2 diabetic nephropathy?
Studies have shown that spironolactone has positive effects on proteinuria, blood pressure, and renal function in type 2 diabetic nephropathy. In a 2006 study, Van den Meiracker et al. found that spironolactone was associated with a reduction in proteinuria, systolic and diastolic blood pressure, and improved renal function in type 2 diabetic nephropathy patients. Additionally, the study found that spironolactone was well tolerated with no adverse events reported. 