6/29/23, 1:42 AM PREPARE Pathway Feedback Search Clinical Topics Home Studies PREPARE PREPARE Disease Asthma Trial question What is the role of patient-activated reliever-triggered ICS therapy in Black and Latinx adults with asthma? Study design Multi-center Open label RCT Population Characteristics of study participants 84.0% female N = 1201 16.0% male 1201 patients (1005 female, 196 male) Inclusion criteria: Black and Latinx adults with moderate-to-severe asthma Key exclusion criteria: being prescribed daily inhaled glucocorticoids; uncontrolled asthma; previous asthma exacerbation leading to the use of systemic glucocorticoids or overnight hospitalization Interventions N=600 reliever-triggered ICS (80 g beclomethasone dipropionate plus usual care) N=601 usual care (provider-enhanced usual care) Primary outcome https://web.pathway.md/studies/rec8nz3LtLBaqnDQ1 1/2 6/29/23, 1:42 AM PREPARE Pathway Annualized rate of severe asthma exacerbations 0.8 0.82 0.69 0.6 0.4 0.2 Significant decrease 0.0 Reliever-triggered inhaled corticosteroid Usual care Significant decrease in annualized rate of severe asthma exacerbations (0.69 vs. 0.82; HR 0.85, 95% CI 0.72 to 0.99) Secondary outcomes Significant increase in mean improvement in asthma control test scores (3.4 points vs. 2.5 points; MD 0.9, 95% CI 0.5 to 1.2) Significant increase in mean improvement in asthma symptom utility index scores (0.12 points vs. 0.08 points; MD 0.04, 95% CI 0.02 to 0.05) Borderline significant decrease in annualized rate of missed days of work, school, or usual activities (13.4 days vs. 16.8 days; RR 0.8, 95% CI 0.67 to 0.95) Safety outcomes No significant differences in serious adverse events, asthma-related hospitalizations. Conclusion In Black and Latinx adults with moderate-to-severe asthma, reliever-triggered ICS was superior to usual care with respect to annualized rate of severe asthma exacerbations. Reference Elliot Israel, Juan-Carlos Cardet, Jennifer K Carroll et al. Reliever-Triggered Inhaled Glucocorticoid in Black and Latinx Adults with Asthma. N Engl J Med. 2022 Apr 21;386(16):1505-1518. Open reference URL https://web.pathway.md/studies/rec8nz3LtLBaqnDQ1 2/2