What is the effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes?
A study conducted by the UK Prospective Diabetes Study Group found that intensive blood-glucose control with metformin reduced the risk of complications in overweight patients with type 2 diabetes by up to 35%. The study, which was published in The Lancet in 1998, found that the risk of all diabetes-related endpoints, including diabetic retinopathy, microvascular complications and macrovascular disease, were significantly reduced with intensive blood-glucose control with metformin. Additionally, a 10-year follow-up study conducted in 2008 found that intensive glucose control was associated with a reduced risk of all-cause mortality in patients with type 2 diabetes.  