What is the effect of dual blockade of the renin-angiotensin system on the progression of type 2 diabetic nephropathy?
A randomized trial conducted by Fernandez Juarez G, Luno J, Barrio V et al. showed that dual blockade of the renin-angiotensin system effectively decreased the progression of type 2 diabetic nephropathy. This was further corroborated by Fried LF et al. in their study that showed that combined angiotensin inhibition is a successful treatment for diabetic nephropathy. Additionally, Sharma P et al. also showed that ACE inhibitors and angiotensin receptor blockers can be used to treat stage 1 to 3 non-diabetic chronic kidney disease. Moreover, Ferrari P et al. demonstrated an additive antiproteinuric effect of ACE inhibition and angiotensin II receptor blockade. Finally, Leon SJ and Tangri N. concluded that the use of renin-angiotensin system inhibitors is effective in patients with chronic kidney disease.