What is the recommendation for clinicians targeting an SBP in patients with CKD?
As worded, the recommendation states that clinicians should target an SBP <120 mm Hg. In practice, adoption of this recommendation in a population of patients with CKD will result in a median SBP around 120 mm Hg, meaning that 50% of patients will have SBP >120 mm Hg at any one time. A more stringent recommendation would be that all patients should achieve an SBP <120 mm Hg. This would require an even lower target or threshold for intervention. However, adoption of this more stringent recommendation would go beyond the available evidence. SPRINT targeted an SBP <120 mm Hg; the mean achieved SBP was 121.4 mm Hg.