7/1/23, 12:44 AM Muscle weakness Pathway Feedback Search Clinical Topics Home Findings Muscle weakness Muscle weakness More common causes Sleep paralysis Kwashiorkor Chronic kidney disease West Nile fever Cachexia Kennedy's disease Hypoglycemia Polymyalgia rheumatica Transient ischemic attack Lumbar disk herniation Vitamin E deficiency Acute ischemic stroke Muscle atrophy Hyperkalemia Myopathy Peripheral neuropathy Disuse atrophy of muscle https://web.pathway.md/findings/recKpEn5KB3zs3mCR 1/4 7/1/23, 12:44 AM Muscle weakness Pathway Proximal muscle weakness Muscular dystrophy Poliomyelitis Thiamine deficiency Marasmus Less common causes Motor neuron disease Progressive external ophthalmoplegia Glycogenosis type 7 Distal muscle weakness Myasthenia gravis Syringomyelia Water intoxication Rhabdomyolysis Intervertebral disc herniation Hypocalcemia Facioscapulohumeral muscular dystrophy Hypomagnesemia Amyotrophic lateral sclerosis Spinal muscular atrophy type 3 Graves' disease Wilson's disease Becker muscular dystrophy Purine nucleoside phosphorylase deficiency Systemic sclerosis https://web.pathway.md/findings/recKpEn5KB3zs3mCR 2/4 7/1/23, 12:44 AM Muscle weakness Pathway Tick paralysis Lower motor neurone lesion Upper motor neuron lesion Multiple sclerosis Coenzyme Q10 deficiency Mitochondrial encephalopathy / lactic acidosis and stroke-like episodes Hypophosphatemia TANGO2-related metabolic encephalopathy and arrhythmias Sphingomyelinase deficiency Peripheral motor neuropathy Cushing's disease Adrenoleukodystrophy Botulism Hypermagnesaemia Uncommon causes Acquired neuromyotonia Subacute combined degeneration of the cord LAMA2-related muscular dystrophy Autosomal recessive congenital muscular dystrophy Fukuyama congenital muscular dystrophy Thyrotoxic hypokalemic periodic paralysis Adenosine monophosphate deaminase deficiency Muscle glycogen synthase deficiency Chediak-Higashi disease 2-methylbutyryl-coenzyme A dehydrogenase deficiency https://web.pathway.md/findings/recKpEn5KB3zs3mCR 3/4 7/1/23, 12:44 AM Muscle weakness Pathway Primary hypokalaemic periodic paralysis Dialysis-related aluminium toxicity Infantile X-linked spinal muscular atrophy Pyle metaphyseal dysplasia Klumpke paralysis Congenital fiber-type disproportion myopathy Autosomal dominant myotonia congenita Succinyl-CoA synthetase deficiency Glycogenosis type 5 https://web.pathway.md/findings/recKpEn5KB3zs3mCR 4/4