What are the recommended regimens for treatment of NVE caused by relatively penicillin-resistant strains?
The regimens for treatment of NVE caused by relatively penicillin-resistant strains (MIC >0.12 <0.5 g/mL) include aqueous crystalline penicillin G and ceftriax- one for a 4-week treatment duration, a 2-week treatment regimen that includes gentamicin for patients with uncomplicated IE, rapid response to therapy, and no underlying renal disease, and vancomycin for a 4-week treatment duration as a reasonable alternative for patients unable to tolerate penicillin or ceftriaxone therapy. The desired trough vancomycin level should range between 10 and 15 g/mL. 