What role do thiazides have in controlling hypertension in CKD patients?
Thiazides and thiazide-like diuretics are most often used and have been assessed in many RCTs involving CKD patients, either as the primary investigational agent or as an add-on therapy. Salt and water retention are major factors contributing to high BP in CKD patients and to morbidity and mortality through systemic or pulmonary edema. Thus, diuretics potentially have an important role in the control of hypertension in this clinical setting.