What are the benefits of statin therapy in adults with diabetes mellitus between the ages of 40 and 75?
Most adults 40 to 75 years of age with diabetes mellitus are at intermediate or high-risk (PCE 7.5% 10-year risk) of ASCVD events. Three of 4 double-blinded primary-prevention RCTs of moderate statin therapy in large cohorts with diabetes mellitus in this age range showed significant reductions in ASCVD. A meta-analysis of these trials found that moderate-intensity statin therapy is associated with a risk reduction of 25%, resulting in a risk level similar to that of people without diabetes mellitus and with no apparent difference in benefit between type 1 and type 2 diabetes mellitus.