What is the efficacy of more intensive lowering of LDL cholesterol?
The Cholesterol Treatment Trialist's (CTT) Collaboration reported that more intensive lowering of LDL cholesterol was associated with a further reduction in major vascular events and cardiovascular and all-cause mortality. The meta-analysis of data from 170,000 participants in 26 randomized trials showed that more intensive LDL cholesterol lowering was associated with a 15% relative risk reduction in major vascular events, a 19% relative risk reduction in cardiovascular mortality, and a 13% relative risk reduction in all-cause mortality. 