What are the criteria for diagnosing acute myocardial necrosis?
For the diagnosis of acute myocardial necrosis, it is important to determine not only the peak troponin value, but also serial changes: 1. A troponin value above the 99th percentile of the upper reference level is required. Additionally, evidence for a serial increase or decrease 20% is required if the initial value is elevated.21,178 2. For any troponin values below or close to the 99th percentile, evidence for acute myocardial necrosis is indicated by a change of 3 standard deviations of the variation around the initial value as determined by the 3. Clinical laboratory reports should indicate whether sig- nificant changes in cardiac troponin values for the par- ticular assay have occurred.