6/29/23, 1:42 AM PREPIC 2 Pathway Feedback Search Clinical Topics Home Studies PREPIC 2 PREPIC 2 Disease Disease Deep vein thrombosis Pulmonary embolism Trial question What is the role of retrievable IVC filter plus anticoagulation in patients with acute VTE? Study design Multi-center Open label RCT Population Characteristics of study participants 52.0% female N = 399 48.0% male 399 patients (207 female, 192 male) Inclusion criteria: hospitalized patients with acute, symptomatic PE associated with lower-limb vein thrombosis and at least 1 criterion for severity Key exclusion criteria: insertion of a vena cava filter indicated because of a transient or permanent contraindication to anticoagulation therapy or because recurrent thromboembolism had occurred despite adequate anticoagulant therapy, vena cava filter already inserted, noncancer surgery within the past 3 months or cancer surgery within the past 10 days, life expectancy < 6 months, and pregnancy Interventions N=200 IVC filter implantation (filter implantation plus anticoagulation) N=199 no IVC filter implantation (anticoagulation alone with no filter implantation) https://web.pathway.md/studies/rec1fVmF0DbFdh06m 1/2 6/29/23, 1:42 AM PREPIC 2 Pathway Primary outcome Symptomatic recurrent pulmonary embolism at 3 months 3.0 % 3 2.3 % 1.5 % 1.5 0.8 % No significant difference 0.0 % Inferior vena cava filter implantation No inferior vena cava filter implantation No significant difference in symptomatic recurrent PE at 3 months (3% vs. 1.5%; RR 2, 95% CI 0.51 to 7.89) Secondary outcomes No significant difference in recurrent PE at 6 months, Kaplan-Meier estimates (3.5% vs. 2%; HR 1.78, 95% CI 0.52 to 6.09) Safety outcomes No significant difference in major bleeding at 3 months (4% vs. 5%) and major bleeding at 6 months (6.5% vs. 7.5%). Conclusion In hospitalized patients with acute, symptomatic PE associated with lower-limb vein thrombosis and at least 1 criterion for severity, IVC filter implantation was not superior to no IVC filter implantation with respect to symptomatic recurrent PE at 3 months. Reference Mismetti P, Laporte S, Pellerin O et al. Effect of a retrievable inferior vena cava filter plus anticoagulation vs anticoagulation alone on risk of recurrent pulmonary embolism: a randomized clinical trial. JAMA. 2015 Apr 28;313(16):1627-35. Open reference URL https://web.pathway.md/studies/rec1fVmF0DbFdh06m 2/2