What are the anticipated absolute effects of mineralocorticoid receptor antagonists versus placebo for heart failure with reduced ejection fraction?
The anticipated absolute effects of mineralocorticoid receptor antagonists versus placebo for heart failure with reduced ejection fraction are all-cause mortality (83 fewer events per 1000 person-years), all-cause hospitalization (rate ratio of 397 events per 1000 person-years), hospitalization for any cause (221 fewer events per 1000 person-years), and change in NYHA class (improved with 33 more events per 1000 person-years). The quality of evidence for these effects is very low due to risk of bias, imprecision, inconsistency, and indirectness.