What are the rates of major bleeding on VKAs among observational cohorts?
The rates of major bleeding on vitamin K antagonists (VKAs) among observational cohorts are shown in e-Table 8 and demonstrate highly variable rates, ranging Nevertheless, there is significant heterogeneity between the study population characteristics, the inclusion of inception vs experienced OAC cohorts, significant disparity in the exposure period (follow-up) and differences in the definitions of major bleeding employed.