What are the benefits of administering RASi with the highest approved dose that is tolerated?
The Work Group judged that a large majority of physicians would be comfortable initiating RAS blockade treatment and titrating it to the maximum dose approved by regulatory agencies and tolerated by the patient because of its benefits in kidney protection, their familiarity with this drug, and its good safety profile. The benefits from RASi administered in less than maximally recommended doses are less certain, however, if for whatever reason (e.g., hyperkalemia) the patient cannot tolerate the maximum dose, a smaller dose may still be reasonable.