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KEY WORDS: AHA Scientific Statements n cardiovascular diagnostic techniques n coronary artery disease n coronary stenosis n minimally invasive surgical procedures n myocardial ischemia n myocardial revas- cularization n risk factors n stable angina Appendix 1. Author Relationships With Industry and Other Entities (Relevant): 2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS Guidelines for the Diagnosis and Management of Patients With Stable Ischemic Heart Disease Committee Member Employment Consultant Speaker s Bureau Ownership/ Partnership/ Principal Personal Research Institutional, Organizational, or Other Financial Benefit Expert Witness Voting Recusals by Section* Stephan D. Fihn (Chair) Veterans Health Administration Director, Office of Analytics and Business Intelligence; University of Washington Professor of Medicine and of Health Services; Head, Division of General Internal Medicine None None None None None None None (Continued) Appendix 1. Continued Committee Member Employment Consultant Speaker s Bureau Ownership/ Partnership/ Principal Personal Research Institutional, Organizational, or Other Financial Benefit Expert Witness Voting Recusals by Section* Julius M. Gardin (Vice Chair) Hackensack University Medical Center Professor and Chairman, Department of Internal Medicine Arena Pharmaceuticals (Expired Dec. 2008) AstraZeneca (Expired Bristol-Myers Squibb (Expired Dec. 2009) CV Therapeutics (Expired Dec. 2007) Pfizer (Expired Dec. Sanofi-aventis Takeda (Expired Bristol-Myers Squibb (Expired Dec. 2009) CV Therapeutics (Expired Dec. 2007) Pfizer (Expired Dec. Takeda (Expired None Merck (Expired Dec. None None 4.4.1.1 Jonathan Abrams University of New Mexico, Office of CME Professor of Medicine (Cardiology) None None None None None None None Kathleen Berra Stanford Prevention Research Center Clinical Trial Director Boehringer Ingelheim CV Therapeutics Gilead Sciences Novartis Pfizer Sanofi-aventis None Kai Pharmaceuticals PCNA Board Member James C. Blankenship Geisinger Medical Center Director Cardiology; Director Cardiac Catheterization Laboratory None Sanofi-aventis None Abiomed AstraZeneca Boston Scientific Conor Medsystems Kai Pharmaceutical Novartis Schering-Plough The Medicines Company None None 4.4.2.1 Apostolos P. Dallas Carilion Roanoke Memorial Hospital Director of Continuing Medical Education None None GlaxoSmithKline Johnson & Johnson Novartis Sanofi-aventis None None None 4.4.1.1 Pamela S. Douglas Duke University Medical Center Ursula Geller Professor of Research in Cardiovascular Diseases None None None Novartis None None 4.4.1.1 JoAnne M. Foody Harvard Medical School Associate Professor; Brigham and Women s/Faulkner Hospitals Abbott Amarin Gilead Merck Novartis Pfizer Sanofi-aventis None None None None None 2.2.2.2 Thomas C. Gerber Mayo Clinic Radiology, Professor of Medicine None None None None None None None Alan L. Hinderliter University of North Carolina: Division of Cardiology Associate Professor None None None None None None None Spencer B. King III Saint Joseph s Heart and Vascular Institute President; Saint Joseph s Health System Executive Director Academic Affairs Medtronic (Expired None None None Merck (DSMB) Wyeth Pharmaceuticals (DSMB) (Continued) Fihn et al Stable Ischemic Heart Disease: Full Text e465 Appendix 1. Continued Committee Member Employment Consultant Speaker s Bureau Ownership/ Partnership/ Principal Personal Research Institutional, Organizational, or Other Financial Benefit Expert Witness Voting Recusals by Section* Paul D. Kligfield Cornell Medical Center Professor of Medicine Cardiac Science GE Healthcare MDS Pharma Services Mortara Instrument Philips Medical Systems None None None None None 2.2.1 Harlan M. Krumholz Yale University School of Medicine Harold H. Hines, Jr. Professor of Medicine and Epidemiology and Public Health None None None None None None None Raymond Y.K. Kwong Brigham & Women s Hospital Medicine, Cardiovascular Division Instructor of Medicine None None None None None None None Michael J. Lim St. Louis University Associate Professor of Medicine; Division of Cardiology, Interim Director; J. Gerard Mudd Cardiac Catheterization Laboratory, Director Bristol-Myers Squibb Cordis Sanofi-aventis Schering-Plough None None None None None 4.4.1.1 Jane A. Linderbaum Mayo Clinic Assistant Professor of Medicine None None None None None None None Michael J. Mack The Heart Hospital Baylor Plano Director None None None None None None None Mark A. Munger University of Utah College of Pharmacy Professor Pharmacotherapy and Internal Medicine; Associate Dean, Academic Affairs None Gilead None Novartis None None 4.4.3.1 Richard L. Prager University of Michigan Hospitals and Health Centers Professor of Surgery, Section of Cardiac Surgery None None None None None None None Joseph F. Sabik Cleveland Clinic Foundation Professor of Surgery Medtronic Novo Nordisk None None None None None 4.4.1.3 Leslee J. Shaw Emory University School of Medicine Professor of Medicine None None None Bracco Diagnostics None None 3.2.2.6. Joanna D. Sikkema University of Miami School of Nursing None AstraZeneca None None None None 4.4.1.1 Craig R. Smith, Jr Columbia University Chairman, Department of Surgery None None None None None None None Sidney C. Smith, Jr Center for Cardiovascular Science and Medicine Professor of Medicine; Director Eli Lilly (Expired July Sanofi-aventis (Expired Sept. 2009) AstraZeneca (Expired Bayer (Expired Oct. Fornier (Expired May Sanofi-aventis (Expired Nov. 2009) None GlaxoSmithKline (DSMB) (Expired None None 4.4.2.1 (Continued) Appendix 1. Continued Committee Member Employment Consultant Speaker s Bureau Ownership/ Partnership/ Principal Personal Research Institutional, Organizational, or Other Financial Benefit Expert Witness Voting Recusals by Section* John A. Spertus MidAmerica Heart Institute of St. Luke s Hospital Director, Outcomes Research; University of Missouri Kansas City Gilead None None BMS/sanofi- aventis Cordis Eli Lilly Johnson & Johnson Roche Diagnostics None None 4.4.1.1 Sankey V. Williams Hospital of the University of Pennsylvania Solomon Katz Professor of General Medicine, Division of General Internal Medicine None None Johnson & Johnson Merck None None None 4.4.1.1 This table represents the relationships of committee members with industry and other entities that were reported by authors to be relevant to this document. These relationships were reviewed and updated in conjunction with all meetings and conference calls of the writing committee during the document development process. The table does not necessarily reflect relationships with industry at the time of publication. A person is deemed to have a significant interest in a business if the interest represents ownership of $5% of the voting stock or share of the business entity, or ownership of $$10 000 of the fair market value of the business entity; or if funds received by the person from the business entity exceed 5% of the person s gross income for the previous year. A relationship is considered to be modest if it is less than significant under the preceding definition. Relationships in this table are modest unless otherwise noted. *Writing committee members are required to recuse from voting on sections to which their specific relationships with industry and other entities could apply. Section numbers apply to the full-text guideline. Significant relationship. No financial benefit. The current guideline was developed during the transition in RWI policy and occurred over an extended period of time. In the interest of transparency, we provide full information on RWI existing over the entire period of guideline development, including delineation of relationships that expired .24 months before the guideline was finalized. CV indicates cardiovascular; DSMB, data safety and monitoring board; and SAQ, Seattle Angina Questionnaire. Appendix 2. Reviewer Relationships With Industry and Other Entities (Relevant): 2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS Guidelines for the Diagnosis and Management of Patients With Stable Ischemic Heart Disease Reviewer Representation Consultant Speaker Ownership/ Partnership/ Principal Research Institutional, Organizational, or Other Financial Benefit Expert Witness Ralph G. Brindis Official Reviewer ACCF Board of Trustees None None None None None None Timothy D. Henry Official Reviewer AHA CV Therapeutics Sanofi-aventis None None Baxter* CV Therapeutics* None None Judith S. Hochman Official Reviewer ACCF/AHA Task Force on Practice Guidelines Eli Lilly GlaxoSmithKline None None Johnson & Johnson Merck Robert H. Jones Official Reviewer STS None None None None None None Janet B. Long Official Reviewer PCNA None AstraZeneca None None None None Bruce W. Lytle Official Reviewer AATS None None None None None None Douglass A. Morrison Official Reviewer SCAI None None None None None None E. Magnus Ohman Official Reviewer AHA Abiomed Datascope Inovise* Liposcience The Medicines Company Response Biomedical CV Therapeutics* The Medicines Company* Inovise* Bristol-Myers Squibb* Daiichi-Sankyo* Eli Lilly* The Medicines Company* Millennium Pharmaceuticals* Sanofi-aventis* Schering-Plough* None None (Continued) Fihn et al Stable Ischemic Heart Disease: Full Text e467 Appendix 2. Continued Reviewer Representation Consultant Speaker Ownership/ Partnership/ Principal Research Institutional, Organizational, or Other Financial Benefit Expert Witness Douglas K. Owens Official Reviewer ACP GE Healthcare* None None None None None Paul Poirier Official Reviewer ACCF Board of Governors None None None None None None Amir Qaseem Official Reviewer ACP None None None None None None Joyce L. Ross Official Reviewer PCNA Kaneka America Abbott AstraZeneca* Bristol-Myers Squibb Oscient Pfizer Sanofi-aventis None None None None Timothy A. Sanborn Official Reviewer SCAI None The Medicines Company Merck None St. Jude Medical (DSMB) None None Jeffrey L. Anderson Content Reviewer ACCF/AHA Task Force on Practice Guidelines BMS/sanofi-aventis Daiichi-Sankyo Eli Lilly None None None None None William E. Boden Content Reviewer Abbott CV Therapeutics/ Gilead* Sanofi-aventis Schering-Plough Medicure Pharma None None None None Matthew Budoff Content Reviewer ACCF Imaging Council None None None None None None Kim A. Eagle Content Reviewer None None None None None None Gordon A. Ewy Content Reviewer None None None None None None Victor Ferrari Content Reviewer ACCF Imaging Council None None None None None None Raymond J. Gibbons Content Reviewer Cardiovascular Clinical Studies Lantheus Medical Imaging Medscape Molecular Insight TherOx None None Velomedix* None None Linda Gillam Content Reviewer ACCF Imaging Council Abbott Vascular Edwards Lifesciences None None None Core Lab Services None Robert A. Guyton Content Reviewer ACCF/AHA Task Force on Practice Guidelines None None None Edwards Lifesciences None None L. David Hillis Content Reviewer None None None None None None David R. Holmes Content Reviewer ACCF Interventional Scientific Council None None None None None None Hani Jneid Content Reviewer AHA Council on Clinical Cardiology None None None None None None Sanjay Kaul Content Reviewer None None None None None None Howard C. Lewin Content Reviewer ACCF Imaging Council None None Positron Imaging Partners None None None (Continued) Appendix 2. Continued Reviewer Representation Consultant Speaker Ownership/ Partnership/ Principal Research Institutional, Organizational, or Other Financial Benefit Expert Witness Todd D. Miller Content Reviewer AHA Council on Clinical Cardiology The Medicines Company TherOx None None Kai Pharmaceuticals King Pharmaceuticals Lantheus Medical Imaging Molecular Insight Pharmaceuticals None None L. Kristin Newby Content Reviewer AHA Council on Clinical Cardiology Adolor Biovascular CV Therapeutics Inverness Medical Johnson & Johnson Novartis Roche Diagnostics Daiichi-Sankyo None AstraZeneca BG Medicine Carvio Dx* GlaxoSmithKline* Medicare* Millennium Pharmaceuticals Schering-Plough* None None Elizabeth Ross Content Reviewer None None None None None None William S. Weintraub Content Reviewer AstraZeneca* Bayer* Bristol-Myers Squibb Cardionet Eli Lilly Pfizer* Sanofi-aventis Shionogi None None Abbott* AstraZeneca* Bristol-Myers Squibb* Otsuka* Sanofi-aventis* None 2004; Defendant; Aprotinin 2008; Defendant; Quetiapine 2008; Defendant; Celebrex This table represents the relationships of reviewers with industry and other entities that were disclosed at the time of peer review. It does not necessarily reflect relationships with industry at the time of publication. A person is deemed to have a significant interest in a business if the interest represents ownership of $5% of the voting stock or share of the business entity, or ownership of $$10 000 of the fair market value of the business entity; or if funds received by the person from the business entity exceed 5% of the person s gross income for the previous year. A relationship is considered to be modest if it is less than significant under the preceding definition. Relationships noted in this table are modest unless otherwise noted. *Significant relationship. AATS indicates American Association for Thoracic Surgery; ACCF, American College of Cardiology Foundation; ACP, American College of Physicans; AHA, American Heart Association; NIH, National Institutes of Health; PCNA, Preventive Cardiovascular Nurses Association; SCAI, Society for Cardiovascular Interventions and Angiography; and STS, Society of Thoracic Surgeons. Fihn et al Stable Ischemic Heart Disease: Full Text e469 Appendix 3. Abbreviations List ACE 5 angiotensin-converting enzyme ACS 5 acute coronary syndrome AMI 5 acute myocardial infarction ARB 5 angiotensin-receptor blocker AV 5 atrioventricular BMI 5 body mass index BMS 5 bare-metal stent BP 5 blood pressure CABG 5 coronary artery bypass graft CAC 5 coronary artery calcium CAD 5 coronary artery disease CCS 5 Canadian Cardiovascular Society CCTA 5 coronary/cardiac computed tomography angiography CKD 5 chronic kidney disease CMR 5 cardiac magnetic resonance CT 5 computed tomography DAPT 5 dual antiplatelet therapy DES 5 drug-eluting stent ECG 5 electrocardiogram EDTA 5 ethylene diamine tetraacetic acid EECP 5 enhanced external counterpulsation EF 5 ejection fraction FDA 5 US Food and Drug Administration FFR 5 fractional flow reserve GDMT 5 guideline-directed medical therapy HDL 5 high-density lipoprotein HIV 5 human immunodeficiency virus IHD 5 ischemic heart disease LAD 5 left anterior descending LBBB 5 left bundle-branch block LDL 5 low-density lipoprotein LGE 5 late gadolinium enhancement LIMA 5 left internal mammary artery LV 5 left ventricular LVEF 5 left ventricular ejection fraction MACE 5 major adverse cardiac event MET 5 metabolic equivalent MI 5 myocardial infarction MPI 5 myocardial perfusion imaging NSTEMI 5 non ST-elevation myocardial infarction PAD 5 peripheral artery disease PCI 5 percutaneous coronary intervention PET 5 positron emission tomography PHQ 5 Patient Health Questionnaire RCT 5 randomized controlled trial SAQ 5 Seattle Angina Questionnaire SIHD 5 stable ischemic heart disease (Continued) Appendix 3. Continued SPECT 5 single-photon emission computed tomography STEMI 5 ST-elevation myocardial infarction TMR 5 transmyocardial revascularization UA 5 unstable angina UA/NSTEMI 5 unstable angina/non ST-elevation myocardial infarction Appendix 4. Nomogram for Estimating 2-Year CAD Event-Free Survival (ie, Freedom From CAD Death or Nonfatal MI) by Using Percent Ischemic Myocardium in Intermediate-Likelihood Patients by Post-Stress LV CAD indicates coronary artery disease, LVEF, left ventricular ejection fraction; MI, myocardial infarction; and SPECT, single-photon emission computed tomography. Reproduced with permission from Shaw et al.276 Fihn et al Stable Ischemic Heart Disease: Full Text e471