6/28/23, 12:42 AM ANTICIPUSC Pathway Feedback Search Clinical Topics Home Studies ANTICIPUSC ANTICIPUSC Disease Esophageal cancer Trial question What is the role of prophylactic noninvasive ventilation in patients at high-risk of postoperative pulmonary complications? Study design Multi-center Open label RCT Population Characteristics of study participants 20.0% female N = 253 80.0% male 253 patients (50 female, 203 male) Inclusion criteria: patients at high risk of postoperative pulmonary complications after elective or semi-urgent surgery with an Assess Respiratory Risk in Surgical Patients in Catalonia score 45 Key exclusion criteria: obstetrical interventions; pregnancy; surgery under local anesthesia; organ transplantation; outpatient surgery Interventions N=125 prophylactic noninvasive ventilation (intermittent prophylactic face-mask noninvasive ventilation for 6-8 hours/day) N=128 usual postoperative care (standard care after surgery in postoperative unit) https://web.pathway.md/studies/recWg0TKxNKMpudPK 1/2 6/28/23, 12:42 AM ANTICIPUSC Pathway Primary outcome Rate of in-hospital acute respiratory failure within 7 days after surgery 27.3 % 27.3 24 20.5 % 13.7 % 6.8 % No significant difference 0.0 % Prophylactic noninvasive ventilation Usual postoperative care No significant difference in the rate of in-hospital acute respiratory failure within 7 days after surgery (24% vs. 27.3%; OR 0.97, 95% CI 0.9 to 1.04) Secondary outcomes No significant difference in Atelectasis (48.8% vs. 57%; ARD -8.2, 95% CI -21.81 to 5.41) No significant difference in Re-intubation (7.2% vs. 6.3%; AD 0.9%, 95% CI -4.57 to 6.37) Conclusion In patients at high risk of postoperative pulmonary complications after elective or semi-urgent surgery with an Assess Respiratory Risk in Surgical Patients in Catalonia score 45, prophylactic noninvasive ventilation was not superior to usual postoperative care with respect to the rate of in- hospital acute respiratory failure within 7 days after surgery. Reference Stanislas Abrard, Emmanuel Rineau, Valerie Seegers et al. Postoperative prophylactic intermittent noninvasive ventilation versus usual postoperative care for patients at high risk of pulmonary complications: a multicentre randomised trial. Br J Anaesth. 2023 Jan;130(1):e160-e168. Open reference URL https://web.pathway.md/studies/recWg0TKxNKMpudPK 2/2