What is the impact of major bleeding on 30-day mortality and clinical outcomes in patients with acute coronary syndromes?
A study from the ACUITY Trial showed that in-hospital major bleeding during ST-elevation and non-ST-elevation myocardial infarction care was associated with an increased risk of 30-day mortality and adverse clinical outcomes. Other studies have also shown that red blood cell transfusions and anticoagulant agents are associated with an increased risk of bleeding among patients admitted with myocardial infarction. In addition, a risk score to predict bleeding in patients with acute coronary syndromes has been developed from the National Cardiovascular Data Registry's ACTION Registry-GWTG.  