What genetic factors are associated with stroke?
Loss-of-function mutations in KRIT1, malcavernin, and PDCD10 genes can cause cerebral cavernous malformation syndrome, while mutations in can cause inherited cerebral amyloid angiopathy syndromes. Furthermore, intracranial aneurysms occur in 8% of individuals with autosomal-dominant polycystic kidney disease and 7% with cervical fibromuscular dysplasia. Ehlers-Danlos type IV is also associated with dissection of vertebral and carotid arteries, carotid-cavernous fistulas, and intracranial aneurysms.