What is the recommendation for people with high BP, CKD, and moderately-to-severely increased albuminuria with diabetes?
We recommend starting RASi (ACEi or ARB) for people with high BP, CKD, and moderately-to-severely increased albuminuria (G1 G4, A2 and A3) with diabetes (1B). This is a strong recommendation based on evidence from RCTs of suf cient duration to evaluate kidney protection in patients with diabetes and CKD. This recommendation places a relatively higher value on preventing long-term progression of CKD and a relatively lower value on the risks of AKI or hyperkalemia, which are often transient.