What is the risk of ischemic stroke associated with migraine with aura?
A meta-analysis of 21 studies (13 case-control and 8 cohort) reported an overall pooled RR of 2.04 (95% CI, 1.72 - 32.68) for migraine with aura. A second meta-analysis of 9 studies (6 case-control and 3 cohort) reported a pooled RR of 2.16 (95% CI, 1.53 - 3.03) for migraine with aura. Women had a greater risk than men (RR, 2.08, 95% CI, 1.13 - 3.84). The risk was further increased with age <45 years (RR, 3.65; 95% CI, 2.21 - 6.04) and with smoking (RR, 2.51; 95% CI, 1.52 - 4.14).