6/29/23, 1:42 AM PREPARE II Pathway Feedback Search Clinical Topics Home Studies PREPARE II PREPARE II Trial question What is the effect of fluid bolus administration in critically ill adults undergoing tracheal intubation? Study design Multi-center Open label RCT Population Characteristics of study participants 42.0% female N = 1065 58.0% male 1065 patients (448 female, 617 male) Inclusion criteria: critically ill adults undergoing tracheal intubation with sedation and positive pressure ventilation Key exclusion criteria: immediate need for tracheal intubation precluding randomization; indication or contraindication for fluid bolus administration Interventions N=538 fluid bolus (500 mL intravenous infusion of isotonic crystalloid solution of the clinician's choice) N=527 no fluid bolus (initiation of a new intravenous fluid bolus not permitted except as treatment for hypotension) Primary outcome Cardiovascular collapse 21.0 % 21 18.2 15.8 % 10.5 % https://web.pathway.md/studies/reconuVj1tPPmN6Jc 1/2 6/29/23, 1:42 AM PREPARE II Pathway No significant difference 5.3 % 0.0 % Fluid bolus No fluid bolus No significant difference in cardiovascular collapse (21% vs. 18.2%; AD 2.8%, 95% CI -2.2 to 7.7) Secondary outcomes No significant difference in the rate of death prior to day 28 (40.5% vs. 42.3%; ARD -1.8, 95% CI -7.9 to 4.3) No significant difference in severe hypoxemia (14.9% vs. 13.7%; AD 1.2%, 95% CI -3.3 to 5.6) No significant difference in median invasive mechanical ventilation-free days through day 28 (14 days vs. 12 days; MD 2, 95% CI -10 to 15) Conclusion In critically ill adults undergoing tracheal intubation with sedation and positive pressure ventilation, fluid bolus were not superior to no fluid bolus with respect to cardiovascular collapse. Reference Derek W Russell, Jonathan D Casey, Kevin W Gibbs et al. Effect of Fluid Bolus Administration on Cardiovascular Collapse Among Critically Ill Patients Undergoing Tracheal Intubation: A Randomized Clinical Trial. JAMA. 2022 Jul 19;328(3):270-279. Open reference URL https://web.pathway.md/studies/reconuVj1tPPmN6Jc 2/2