What research recommendations have been made to improve knowledge of the advantages and disadvantages of specific doses and classes of anti-hypertensive agents in this population?
Long-term observational studies of the onset of target- organ damage in children with CKD are necessary to obtain evidence on which to base thresholds for BP treatment and targets rather than relying on population- based percentiles. Large, long-term randomized trials addressing targets and comparing various agents to prevent target-organ damage are also necessary to improve knowledge of the advantages and disadvantages of specific doses and classes of anti-hypertensive agents in this population.