What are the effects of propofol, midazolam and thiopental sodium on outcome and amino acids accumulation in focal cerebral ischemia-reperfusion in rats?
According to a study published in the Chinese Medical Journal in 2003, the effects of propofol, midazolam and thiopental sodium on outcome and amino acids accumulation in focal cerebral ischemia-reperfusion in rats had been observed. The results showed that the administration of propofol, midazolam and thiopental sodium resulted in a decreased brain water content and an increased cerebral infarction area. In addition, the study found that the administration of midazolam and thiopental sodium caused a significant decrease in the accumulation of amino acids in the brain. These findings suggest that the administration of propofol, midazolam and thiopental sodium may have a protective effect on the brain during ischemia-reperfusion injury.