6/29/23, 1:34 AM PARTNER Pathway Feedback Search Clinical Topics Home Studies PARTNER PARTNER Trial question What is the role of a family-support intervention delivered by the interprofessional ICU team among critically ill patients and their surrogates? Study design Multi-center Open label RCT Population Characteristics of study participants 49.0% female N = 1420 51.0% male 1420 patients (695 female, 725 male) Inclusion criteria: ICU patients with a high risk of death and their surrogates Key exclusion criteria: no surrogate decision-maker or receipt of only comfort-focused treatment, surrogates < 18 years of age, or unable to read or understand English Interventions N=547 family-support intervention (a multicomponent family-support intervention delivered by the interprofessional ICU team with 429 surrogates) N=873 control (usual care, with 677 surrogates) Primary outcome Surrogates' mean score on Hospital Anxiety and Depression Scale at 6 months 12.0 12 11.7 9.0 6.0 3.0 https://web.pathway.md/studies/recmC5YnAS1Todo8t 1/2 6/29/23, 1:34 AM PARTNER Pathway No significant difference 0.0 Family-support intervention Control No significant difference in surrogates' mean score on the Hospital Anxiety and Depression Scale at 6 months (11.7 vs. 12; AD -0.34, 95% CI -1.67 to 0.99) Secondary outcomes No significant difference in surrogates' mean scores on the Impact of Event Scale (21.2 vs. 20.3; AD 0.9, 95% CI -1.66 to 3.47) Significant increase in surrogates' mean Quality of Communication score (69.1 vs. 62.7; AD 6.39, 95% CI 2.57 to 10.2) Significant decrease in length of ICU stay (6.7 days vs. 7.4 days; IRR 0.9, 95% CI 0.81 to 1) Safety outcomes No significant differences in death at 6 months, living independently at home at 6 months. Significant differences in modified Patient Perception of Patient Centeredness score (1.7 vs. 1.8), death in the hospital (36.0% vs. 28.5%). Conclusion In ICU patients with a high risk of death and their surrogates, family-support intervention was not superior to control with respect to surrogates' mean score on the Hospital Anxiety and Depression Scale at 6 months. Reference Douglas B White, Derek C Angus, Anne-Marie Shields et al. A Randomized Trial of a Family- Support Intervention in Intensive Care Units. N Engl J Med. 2018 Jun 21;378(25):2365-2375. Open reference URL https://web.pathway.md/studies/recmC5YnAS1Todo8t 2/2