6/28/23, 10:12 PM Effect of Propranolol in TBI Pathway Feedback Search Clinical Topics Home Studies Effect of Propranolol in TBI Effect of Propranolol in TBI Disease Traumatic brain injury Trial question What is the effect of propranolol in patients with severe TBI? Study design Single center Open label RCT Population Characteristics of study participants 14.0% female N = 219 86.0% male 219 patients (30 female, 189 male) Inclusion criteria: adult patients with a severe TBI, intracranial Abbreviated Injury Scale 3 Key exclusion criteria: pre-injury -blocker therapy, persistent shock at 24 h after admission, and transfer from another hospital Interventions N=99 -blocker therapy positive (20 mg propranolol PO every 12 hours up to 10 days or until discharge) N=120 -blocker therapy negative (no propranolol) Primary outcome Death in hospital 16.7 % 16.7 12.5 % https://web.pathway.md/studies/recq4EM27gwfXHw6B 1/2 6/28/23, 10:12 PM Effect of Propranolol in TBI Pathway 8.3 % 8.1 4.2 % No significant difference 0.0 % Beta-blocker therapy positive Beta-blocker therapy negative No significant difference in death in the hospital (8.1% vs. 16.7%; aIRR 0.6, 95% CI 0.3 to 1.4) Secondary outcomes Significant decrease in death in the hospital in patients with isolated TBI (4.4% vs. 18.6%; aIRR 0.32, 95% CI 0.1 to 0.9) Significant increase in the rate of functional outcome at 6-month follow up Glasgow Outcome Scale-Extended 5 in patients with isolated TBI (92.3% vs. 79.1%; aIRR 1.2, 95% CI 1 to 1.3) No significant difference in the rate of functional outcome at 6-month follow up Glasgow Outcome Scale-Extended 5 (86.5% vs. 77.5%; aIRR 1.1, 95% CI 0.9 to 1.2) Safety outcomes No significant difference in good functional outcome at discharge in patients with severe TBI and isolated severe TBI. Conclusion In adult patients with a severe TBI, intracranial Abbreviated Injury Scale 3, -blocker therapy positive was not superior to -blocker therapy negative with respect to death in the hospital. Reference Hosseinali Khalili, Rebecka Ahl, Shahram Paydar et al. Beta-Blocker Therapy in Severe Traumatic Brain Injury: A Prospective Randomized Controlled Trial. World J Surg. 2020 Jun;44(6):1844-1853. Open reference URL https://web.pathway.md/studies/recq4EM27gwfXHw6B 2/2