what are the Recommendations for Primary Severe Hypercholesterolemia
(LDL-C ≥190 mg/dL [≥4.9 mmol/L])
Referenced studies that support recommendations are summarized
in Online Data Supplements 9 and 10.?
In patients 30 to 75 years of age with heterozygous FH and with an LDL-C level of 100 mg/dL or higher (?2.6 mmol/L) while taking maximally tolerated statin and ezetimibe therapy, the addition of a PCSK9 inhibitor may be considered.S