What does the Cochrane review indicate about treating high blood pressure in patients aged 460 years with chronic kidney disease?
The Cochrane review indicated that active treatment of high blood pressure in patients aged 460 years with chronic kidney disease reduced total mortality (RR 0.90; 95% CI 0.84 0.97) and total cardiovascular mortality and morbidity (RR 0.72; 95% CI 0.68 0.77). However, when patients aged 80 years or older were specifically considered, there was no overall reduction in the risk of total mortality with treatment of BP vs. no treatment (RR 1.01; 95% CI 0.90 1.13). Withdrawals due to adverse events were poorly documented, but in three RCTs that did report these data, treatment was associated with 111 events/ 1000 patient-years, as compared with 65 events/1000 patient- years with placebo (RR 1.71; 95% CI 1.45 2.00). 