What is the purpose of the LIFE Trial?
The purpose of the LIFE Trial is to evaluate the efficacy of sacubitril/valsartan in advanced heart failure with reduced ejection fraction. It is a randomized, double-blind, placebo-controlled, multinational trial designed to assess the effect of sacubitril/valsartan on the primary outcome of time to first occurrence of cardiovascular death or the first hospitalization for heart failure. It also assesses the secondary outcomes of cardiovascular mortality, all-cause mortality, quality of life, and health-related quality of life. The study will include over 10,000 patients from over 30 countries.