What is the recommended target range for INR when using VKAs for non-valvular AF?
Clinical guidelines on the management of AF advocate an individual Targeted Therapy Ratio (TTR) of at least 65% to maximize efficacy and safety, and this should be the treatment target. An analysis of anticoagulation control in the Global Anticoagulation Registry in the Field [GARFIELD-AF] registry revealed that only 51.4% of INR values were in the therapeutic range (INR, 2.0 to 3.0). Recommendation 10 states that for patients with non-valvular AF, when VKAs are used, the target should be INR 2.0-3.0, with attention to individual TTR, ideally 70%.