What are the inclusion and exclusion criteria for the Mulder SENIORS study?
The inclusion criteria for the Mulder SENIORS study are a clinical history of chronic heart failure with at least one of the following features: documented hospital admission within the previous 12 months with a discharge diagnosis of congestive heart failure or documented LVEF 35% within the previous 6 months failure in the 6 weeks prior to randomization a change in cardiovascular drug therapy in the 2 weeks prior to randomization. The exclusion criteria for the Mulder SENIORS study are heart failure due primarily to uncorrected valvular heart disease contraindication or previous intolerance to beta-blockers (e.g. heart rate < 60 bpm or systolic blood pressure <90 mm Hg) current use of beta-blockers significant hepatic or renal dysfunction cerebrovascular accidents within the previous 3 months being on a waiting list for percutaneous coronary intervention or cardiac surgery or other major medical conditions that may have reduced survival during the period of the study.