What is the association between migraine and late-life infarct-like lesions on imaging?
A population-based cohort study in Reykjavik, Iceland found that midlife migraine with aura had an increased risk of late-life infarct-like lesions (OR, 1.4; 95% CI, 1.1 1.8). This was particularly reflected by an association with cerebellar lesions in women (OR, 1.9; 95% CI, 1.4 2.6), however, this association was not seen in men or in those with migraine without aura or nonmigraine headaches. The mechanism and relevance of the migraine brain lesion association are unclear.