6/29/23, 1:10 AM RENOVATE-COMPLEX-PCI Pathway Feedback Search Clinical Topics Home Studies RENOVATE COMPLEX PCI RENOVATE COMPLEX PCI Disease Disease Disease Coronary artery disease Non-ST-elevation myocardial inf ST-elevat Trial question What is the role of intravascular imaging-guided PCI in patients with complex coronary artery lesions? Study design Multi-center Open label RCT Population Characteristics of study participants 21.0% female N = 1639 79.0% male 1639 patients (339 female, 1300 male) Inclusion criteria: adult patients undergoing PCI for complex coronary artery lesions Key exclusion criteria: coronary lesions not appropriate for PCI; cardiogenic shock at presentation; pregnancy; known hypersensitivity or contraindication to aspirin, clopidogrel, prasugrel, ticagrelor Interventions N=1092 intravascular imaging (intravascular imaging-guided PCI with either intravascular ultrasonography or optical coherence tomography) N=547 angiography (angiography-guided PCI) Primary outcome https://web.pathway.md/studies/rect45iiZwDPB5P9y 1/2 6/29/23, 1:10 AM RENOVATE-COMPLEX-PCI Pathway Composite of death from cardiac causes, target-vessel-related myocardial infarction or revascularization 12.3 % 12.3 9.2 % 7.7 6.2 % Significant decrease 3.1 % NNT = 22 0.0 % Intravascular imaging Angiography Significant decrease in composite of death from cardiac causes, target-vessel-related myocardial infarction or revascularization (7.7% vs. 12.3%; HR 0.64, 95% CI 0.45 to 0.89) Secondary outcomes Borderline significant decrease in target-vessel failure without procedure-related myocardial infarction (5.1% vs. 8.7%; HR 0.59, 95% CI 0.39 to 0.9) Borderline significant decrease in composite of target-vessel-related myocardial infarction and death from cardiac causes (5.3% vs. 8.5%; HR 0.63, 95% CI 0.42 to 0.93) No significant difference in death from any cause (5.3% vs. 6.4%; HR 0.71, 95% CI 0.44 to 1.15) Safety outcomes No significant difference in procedure-related complications. Conclusion In adult patients undergoing PCI for complex coronary artery lesions, intravascular imaging was superior to angiography with respect to the composite of death from cardiac causes, target-vessel- related myocardial infarction or revascularization. Reference Joo Myung Lee, Ki Hong Choi, Young Bin Song et al. Intravascular Imaging-Guided or Angiography- Guided Complex PCI. N Engl J Med. 2023 May 4;388(18):1668-1679. Open reference URL https://web.pathway.md/studies/rect45iiZwDPB5P9y 2/2