What is the maximum percentage change of LDL-C levels associated with lifestyle changes and statin therapy?
The maximum percentage change occurs 4 to 12 weeks after therapy is started, at which time drug efficacy or initial adherence to therapy can be evaluated. The maximum percentage change of LDL-C levels associated with lifestyle changes and statin therapy is 50%. Moderate-intensity statins reduce LDL-C levels by another 30% to 49%; high-intensity statins, by 50%. Adding ezetimibe or bile acid sequestrants to statin therapy reduces LDL-C by an additional 15% to 25%. Adding a PCSK9 inhibitor to statin plus ezetimibe causes greater reductions.