6/28/23, 12:43 AM ARDSNet Pathway Feedback Search Clinical Topics Home Studies ARDSNet ARDSNet Disease Acute respiratory distress syndr Trial question Is ventilation with lower tidal volumes superior to traditional tidal volume in patients with ARDS? Study design Multi-center Open label RCT Population Characteristics of study participants 41.0% female N = 861 59.0% male 861 patients (349 female, 512 male) Inclusion criteria: patients with ARDS and acute lung injury Key exclusion criteria: younger than 18 years of age; pregnancy; increased ICP, neuromuscular disease that could impair spontaneous breathing, sickle cell disease, or severe chronic respiratory disease; bone marrow or lung transplantation; chronic liver disease Interventions N=432 ventilation with lower tidal volumes (initial tidal volume of 6 mL/kg of predicted body weight and a plateau pressure 30 cmH O) N=429 traditional tidal volume (initial tidal volume of 12 mL/kg of predicted body weight and plateau pressure 50 cmH O) https://web.pathway.md/studies/reciLDwFqOMCg3XGM 1/2 6/28/23, 12:43 AM ARDSNet Pathway Primary outcome Hospital death 39.8 % 39.8 31 29.8 % 19.9 % Significant decrease 9.9 % NNT = 11 0.0 % Ventilation with lower tidal volumes Traditional tidal volume Significant decrease in hospital death (31% vs. 39.8%; RR 0.78, 95% CI 2.4 to 15.3) Secondary outcomes Significant increase in ventilator-free days at 28 days (12 days vs. 10 days; ARD 2, 95% CI 0.55 to 3.45) Conclusion In patients with ARDS and acute lung injury, ventilation with lower tidal volumes were superior to traditional tidal volume with respect to hospital death. Reference Brower RG, Matthay MA, Morris A et al. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med. 2000 May 4;342(18):1301-8. Open reference URL https://web.pathway.md/studies/reciLDwFqOMCg3XGM 2/2