6/28/23, 1:16 AM DELIVER Pathway Feedback Search Clinical Topics Home Studies DELIVER DELIVER Disease Heart failure Trial question What is the role of dapagliflozin in patients with HF and a mildly reduced or preserved ejection fraction? Study design Multi-center Double blinded RCT Population Characteristics of study participants 44.0% female N = 6263 56.0% male 6263 patients (2747 female, 3516 male) Inclusion criteria: patients with HF and a LVEF > 40% Key exclusion criteria: T1DM mellitus; receipt of sodium-glucose cotransporter 2 inhibitor within 4 weeks of randomization; or previous intolerance to sodium-glucose cotransporter 2 inhibitor; impaired kidney function Interventions N=3131 dapagliflozin (at a dose of 10 mg/day plus usual therapy) N=3132 placebo (matching placebo plus usual therapy) Primary outcome https://web.pathway.md/studies/rechUMdTpDYP4WFnn 1/2 6/28/23, 1:16 AM DELIVER Pathway Worsening heart failure or cardiovascular death 19.5 % 19.5 16.4 14.6 % 9.8 % Significant decrease 4.9 % NNT = 32 0.0 % Dapagliflozin Placebo Significant decrease in worsening HF or cardiovascular death (16.4% vs. 19.5%; HR 0.82, 95% CI 0.73 to 0.92) Secondary outcomes Significant decrease in the incidence of worsening HF events and cardiovascular deaths (11.8 events/100 person-year vs. 15.3 events/100 person-year; RR 0.77, 95% CI 0.67 to 0.89) No significant difference in death from any cause (15.9% vs. 16.8%; HR 0.94, 95% CI 0.83 to 1.07) No significant difference in cardiovascular death (7.4% vs. 8.3%; HR 0.88, 95% CI 0.74 to 1.05) Safety outcomes No significant difference in adverse events and serious adverse events. Conclusion In patients with HF and a LVEF > 40%, dapagliflozin was superior to placebo with respect to worsening HF or cardiovascular death. Reference Scott D Solomon, John J V McMurray, Brian Claggett et al. Dapagliflozin in Heart Failure with Mildly Reduced or Preserved Ejection Fraction. N Engl J Med. 2022 Sep 22;387(12):1089-1098. Open reference URL https://web.pathway.md/studies/rechUMdTpDYP4WFnn 2/2