What is the purpose of the PARADIGM-HF trial?
The purpose of the PARADIGM-HF trial, as described in Myhre et al. (2018), is to investigate the effects of sacubitril/valsartan therapy on biomarkers, symptom improvement, and ventricular remodeling in patients with heart failure. Specifically, the trial aims to measure the impact of the drug on B-type natriuretic peptide levels, clinical symptoms, and changes in left ventricular mass index.