What is the evidence showing regarding the effects of omega-3 supplementation on cardiovascular disease risk?
The systematic review by Abdelhamid et al. (2018) evaluated 79 RCTs for the effect of omega-3 supplements on primary and secondary prevention of CVD. The evidence showed no statistically significant effect of omega-3 supplementation on CV mortality, composite CV events, MI, stroke, or all-cause mortality. The risk of bias was low for 25 RCTs and moderate-to-high in the remaining 54 RCTs. In this systematic review, omega-3 supplementation ranged from 0.5 grams/day to greater than 5 grams/day.