What were the results of the GISSI-Prevenzione trial?
The GISSI-Prevenzione trial was conducted to assess the effects of dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction. The results of the trial showed that dietary supplementation with n-3 polyunsaturated fatty acids decreased the risk of sudden death and total mortality by approximately 30%, and that vitamin E did not have any significant effect in reducing mortality. Additionally, the trial also showed that n-3 polyunsaturated fatty acids were found to have antiarrhythmic mechanisms. 