What diagnostic accuracy do PCR and ACR tests have for proteinuria?
Protein:creatinine ratio (PCR) and albumin:creatinine ratio (ACR) were both shown to have high specificity and high sensitivity at the chosen thresholds (30 mg/mmol and 8 mg/mmol respectively), and therefore either could be used depending on local availability. Evidence from a single study showed high sensitivity and specificity for an ACR result of 8 mg/mmol to diagnose proteinuria, and there was further evidence from a large, UK-based study, which provided further evidence for the efficacy of a threshold of 8 mg/mmol in the diagnosis of severe pre-eclampsia.