What are the risk factors and risk categories associated with bleeding events in validation cohorts?
The risk factors associated with bleeding events in validation cohorts include age, biomarkers (GDF-15 or cystatin C/CKD-EPI, cTnT-hs, and Hb), previous bleed history, renal function, APT, anemia, severe renal disease, systolic blood pressure, severe renal or hepatic disease, stroke, labile INR, age over 75, hepatic or renal disease, ethanol abuse, malignancy, reduced platelet count/function, hypertension, anemia, genetic factors, excessive fall risk, and stroke. The risk categories include low, intermediate, and high. The bleeding events in validation cohorts (per 100 patient-years) in the risk categories are low (0.49), intermediate (0.31, 0.58, 0.62), and high (1 point each). 