What is the association between lower LDL-C and cardiovascular risk reduction?
A systematic review and meta-analysis published in the Journal of the American Medical Association in 2016 found that lower LDL-C levels were associated with a reduction in cardiovascular risk across different therapeutic interventions. These findings were supported by several clinical trials, including the Ezetimibe trial conducted in 2015 and the Evolocumab trial conducted in 2017.