6/28/23, 11:09 PM HiFlo-COVID Pathway Feedback Search Clinical Topics Home Studies HiFlo-COVID HiFlo-COVID Disease COVID 19 infection Trial question Is high-flow oxygen therapy through a nasal cannula superior to conventional oxygen therapy in patients with severe COVID-19? Study design Multi-center Open label RCT Population Characteristics of study participants 33.0% female N = 199 67.0% male 199 patients (65 female, 134 male) Inclusion criteria: adult patients with respiratory distress and a ratio of partial pressure of arterial oxygen to FiO2 < 200 due to COVID-19 Key exclusion criteria: indication for immediate orotracheal intubation, pregnancy, chronic liver disease, active bacterial or fungal infection, history of COPD Interventions N=99 high-flow oxygen therapy (breathing support with high-flow oxygen therapy through a nasal cannula) N=100 conventional oxygen therapy (oxygen therapy by conventional nasal cannula/prongs, venturi mask, or mask with reservoir) Primary outcome Rate of intubation within 28 days https://web.pathway.md/studies/recbaMCybDEXJiR4R 1/2 6/28/23, 11:09 PM HiFlo-COVID Pathway 51.0 % 51 38.3 % 34.3 25.5 % Significant decrease 12.8 % NNT = 6 0.0 % High-flow oxygen therapy Conventional oxygen therapy Significant decrease in the rate of intubation within 28 days (34.3% vs. 51%; HR 0.62, 95% CI 0.39 to 0.96) Secondary outcomes Significant increase in the rate of clinical recovery within 28 days (77.8% vs. 71%; HR 1.39, 95% CI 1 to 1.92) Significant increase in ventilator-free days at day 28 (28 days vs. 24 days; OR 2.08, 95% CI 1.18 to 3.64) No significant difference in death at day 28 (8.1% vs. 16%; HR 0.49, 95% CI 0.21 to 1.16) Safety outcomes No significant differences in suspected bacterial pneumonia, bacteremia. Conclusion In adult patients with respiratory distress and a ratio of partial pressure of arterial oxygen to FiO2 < 200 due to COVID-19, high-flow oxygen therapy was superior to conventional oxygen therapy with respect to the rate of intubation within 28 days. Reference Gustavo A Ospina-Tasc n, Luis Eduardo Calder n-Tapia, Alberto F Garc a et al. Effect of High- Flow Oxygen Therapy vs Conventional Oxygen Therapy on Invasive Mechanical Ventilation and Clinical Recovery in Patients With Severe COVID-19: A Randomized Clinical Trial. JAMA. 2021 Dec 7;326(21):2161-2171. Open reference URL https://web.pathway.md/studies/recbaMCybDEXJiR4R 2/2