6/28/23, 11:07 PM HYVET Pathway Feedback Search Clinical Topics Home Studies HYVET HYVET Disease Hypertension Trial question What is the effect of indapamide treatment in patients 80 years of age with hypertension? Study design Multi-center Double blinded RCT Population Characteristics of study participants 60.0% female N = 3845 40.0% male 3845 patients (2326 female, 1519 male) Inclusion criteria: patients 80 years of age with a sustained systolic BP 160 mmHg Key exclusion criteria: a contraindication to use of the trial medications, accelerated hypertension, secondary hypertension, hemorrhagic stroke in the previous 6 months, HF requiring treatment with antihypertensive medication, gout, clinical dementia, and a requirement of nursing care Interventions N=1933 active-treatment (diuretic indapamide, sustained releases 1.5 mg, if necessary perindopril 2 or 4 mg to achieve the target BP 150/80 mmHg) N=1912 placebo (matching placebo of indapamide, if necessary matching placebo of perindopril) Primary outcome Incidence of stroke at 2 years https://web.pathway.md/studies/recSyBcdoGyXgb1DU 1/2 6/28/23, 11:07 PM HYVET Pathway 17.7/1000 py 17.7 13.3/1000 py 12.4 8.8/1000 py 4.4/1000 py No significant difference 0.0/1000 py Active-treatment Placebo No significant difference in the incidence of stroke at 2 years (12.4 /1000 py vs. 17.7 /1000 py; HR 0.7, 95% CI 0.49 to 1.01) Secondary outcomes Significant decrease in the incidence of death from stroke (6.5 /1000 py vs. 10.7 /1000 py; HR 0.61, 95% CI 0.38 to 0.99) Significant decrease in the incidence of death from any cause (47.2 /1000 py vs. 59.6 /1000 py; HR 0.79, 95% CI 0.65 to 0.95) Significant decrease in the incidence of HF (5.3 /1000 py vs. 14.8 /1000 py; HR 0.36, 95% CI 0.22 to 0.58) Safety outcomes Significant difference in serious adverse events (358 events vs. 448 events). Conclusion In patients 80 years of age with a sustained systolic BP 160 mmHg, active-treatment was not superior to placebo with respect to the incidence of stroke at 2 years. Reference Beckett NS, Peters R, Fletcher AE et al. Treatment of hypertension in patients 80 years of age or older. N Engl J Med. 2008 May 1;358(18):1887-98. Open reference URL https://web.pathway.md/studies/recSyBcdoGyXgb1DU 2/2