What is the evidence for the effects of intensive BP lowering on critical clinical outcomes such as CV events and all-cause mortality?
The evidence for the effects of intensive BP lowering on critical clinical outcomes such as CV events and all-cause mortality is considered to be moderate due to study limitations. The evidence is primarily derived from SPRINT, in which the sample size was large, the effects of intensive BP lowering on clinical outcomes were strong, and there was no heterogeneity in the effects between the CKD and non-CKD subgroups. Results from the subgroup analysis of ACCORD, as well as the joint analysis of the ACCORD and SPRINT data, lend further support, although there were relatively few participants with CKD in ACCORD.