What are the recommendations for treating enterococcal endocarditis with penicillin, vancomycin, and aminoglycosides?
The recommendations for treating enterococcal endocarditis with penicillin, vancomycin, and aminoglycosides are outlined in Table 12. Gentamicin should be administered in daily multiple divided doses (total, 3 mg kg 1 ) rather than a single daily dose to patients with enterococcal IE and normal renal function (Class I; Level of Evidence B). The dose should be adjusted to achieve 1-hour serum concentration of 3 g/mL and a trough concentration of <1 g/mL (Class IIa; Level of Evidence B).  