What is the association between anti-inflammatory agents and left ventricular free wall rupture during acute myocardial infarction?
Silverman and Pfeifer (1987) studied the relation between the use of anti-inflammatory agents and left ventricular free wall rupture during acute myocardial infarction. They found that the use of nonsteroidal anti-inflammatory agents (NSAIDs) was associated with a significantly higher risk of free wall rupture, compared to those who did not use these agents. They concluded that NSAIDs should be avoided during the acute phase of myocardial infarction.