What evidence is there to suggest the importance of diuretic therapy for lowering blood pressure in people with diabetes, CV risk, or increased albuminuria?
The importance of diuretic therapy for lowering BP is suggested by the ADVANCE study comparing treatment with a combination of an ACEi plus diuretic (perindopril plus indapamide) to usual care without a thiazide-type diuretic in 11,140 people aged $55 years with diabetes, CV risk, or increased albuminuria (A2 or A3) over a mean of 4.3 years. The main outcomes were death from CV disease, non-fatal stroke or non-fatal MI, and new or worsening kidney or diabetic eye disease.