6/28/23, 1:20 AM DiDi Pathway Feedback Search Clinical Topics Home Studies DiDi DiDi Disease Dilated cardiomyopathy Trial question What is the role of diltiazem in patients with idiopathic dilated cardiomyopathy? Study design Multi-center Double blinded RCT Population Characteristics of study participants 24.0% female N = 186 76.0% male 186 patients (45 female, 141 male) Inclusion criteria: patients with idiopathic dilated cardiomyopathy diagnosed by coronary angiography, catheterization of left side of heart, and LVEF < 0.50 Key exclusion criteria: hypertension; valvular or congenital heart disease; myocarditis; coronary artery disease; insulin-dependent diabetes mellitus Interventions N=92 diltiazem (at a dose of 60-90 mg TID) N=94 placebo (matching placebo) Primary outcome Transplant listing-free survival https://web.pathway.md/studies/reckQ9fVXSD4JlSj6 1/2 6/28/23, 1:20 AM DiDi Pathway 85.2 % 85.2 80.4 63.9 % 42.6 % 21.3 % No significant difference 0.0 % Diltiazem Placebo No significant difference in transplant listing-free survival (85.2% vs. 80.4%; AD 4.8%, 95% CI -7.27 to 16.87) Secondary outcomes Significant increase in cardiac index at rest in 2 years (0.37 L/min vs. 0.33 L/min; AD 0.04 L/min, 95% CI 0.01 to 0.07) Significant increase in cardiac index at workload in 2 years (0.57 L/min vs. 0.33 L/min; AD 0.24 L/min, 95% CI 0.09 to 0.39) Significant decrease in HR (-7.7 L/min vs. -1.6 L/min; ARD -6.1, 95% CI -9.72 to -2.48) Safety outcomes No significant difference in adverse reactions. Significant difference in PQ interval (0.015 s vs. -0.003 s). Conclusion In patients with idiopathic dilated cardiomyopathy diagnosed by coronary angiography, catheterization of left side of heart, and LVEF < 0.50, diltiazem was not superior to placebo with respect to transplant listing-free survival. Reference H R Figulla, F Gietzen, U Zeymer et al. Diltiazem improves cardiac function and exercise capacity in patients with idiopathic dilated cardiomyopathy. Results of the Diltiazem in Dilated Cardiomyopathy Trial. Circulation. 1996 Aug 1;94(3):346-52. Open reference URL https://web.pathway.md/studies/reckQ9fVXSD4JlSj6 2/2