6/28/23, 11:22 PM NICOVID-REA Pathway Feedback Search Clinical Topics Home Studies NICOVID REA NICOVID REA Disease COVID 19 infection Trial question What is the role of nicotine patches in patients on mechanical ventilation for severe COVID-19 pneumonia? Study design Multi-center Double blinded RCT Population Characteristics of study participants 30.0% female N = 218 70.0% male 218 patients (66 female, 152 male) Inclusion criteria: adult patients who were non-smokers, non-vapers with proven COVID-19 pneumonia receiving invasive mechanical ventilation for < 72 hours Key exclusion criteria: age < 18 years; pregnancy; anticipated duration of mechanical ventilation 48 hours; moribund; malignancy or severe disease with life expectancy < 1 year Interventions N=106 nicotine (transdermal patches at a daily dose of 14 mg until 48 hours following successful weaning from mechanical ventilation or for a maximum of 30 days, followed by a 3-week dose tapering by 3.5 mg/week) N=112 placebo (matching placebo) https://web.pathway.md/studies/reczgpUaXDrMGGwbN 1/2 6/28/23, 11:22 PM NICOVID-REA Pathway Primary outcome Death at day 28 28.0 % 28 28 21.0 % 14.0 % 7.0 % No significant difference 0.0 % Nicotine Placebo No significant difference in death at day 28 (28% vs. 28%; OR 1.03, 95% CI 0.57 to 1.87) Secondary outcomes No significant difference in death at day 60 (38% vs. 37%; OR 1.09, 95% CI 0.62 to 1.9) No significant difference in length of stay in the ICU (17 days vs. 21 days; AD -4 days, 95% CI -8 to 2) Safety outcomes No significant difference in adverse events. Conclusion In adult patients who were non-smokers, non-vapers with proven COVID-19 pneumonia receiving invasive mechanical ventilation for < 72 hours, nicotine was not superior to placebo with respect to death at day 28. Reference Guylaine Labro, Florence Tubach, Lisa Belin et al. Nicotine patches in patients on mechanical ventilation for severe COVID-19: a randomized, double-blind, placebo-controlled, multicentre trial. Intensive Care Med. 2022 Jun 9;1-12. Open reference URL https://web.pathway.md/studies/reczgpUaXDrMGGwbN 2/2