What is the effect of oral contraceptive use on the risk of stroke in women with von Willebrand factor levels?
The largest effect of OC use was in women with von Willebrand factor levels >90th percentile, for whom the OR for stroke was 1.6 (95% CI, 0.8 3.5) in nonusers and increased to 11.4 (95% CI, 5.2 25.3) in OC users. The results of this study demonstrate that OC use appears to further increase the risk of stroke in the setting of endothelial dysfunction.