What is the safety of percutaneous left atrial appendage closure? 
The safety of percutaneous left atrial appendage closure was assessed from the Watchman Left Atrial Appendage System for Embolic Protection in Patients with AF (PROTECT AF) Clinical Trial and the Continued Access Registry. Results showed that the procedure was safe and effective in reducing stroke risk in patients with atrial fibrillation. Device-related thrombus was also assessed, with no significant differences in thrombus or associated clinical outcomes compared to warfarin therapy. 