6/27/23, 11:44 PM BLOCK-HF Pathway Feedback Search Clinical Topics Home Studies BLOCK HF BLOCK HF Disease Heart failure Trial question What is the role of biventricular pacing in patients with AV block and LV systolic dysfunction? Study design Multi-center Double blinded RCT Population Characteristics of study participants 25.3% female N = 918 74.7% male 918 patients (174 female, 517 male) Inclusion criteria: patients with AV block with NYHA class I-III HF and LVEF 50% Key exclusion criteria: previous receipt of a cardiac implantable electrical device, unstable angina, acute myocardial infarction, percutaneous or surgical coronary intervention within 30 days before enrollment, valvular disease with an indication for valve repair or replacement Interventions N=349 biventricular pacing (cardiac-resynchronization pacemaker or ICD with pacing of both the ventricles) N=342 conventional RV pacing (cardiac-resynchronization pacemaker or ICD with pacing of only the right ventricle) Primary outcome Death, urgent care visit for heart failure, or 15% elevation in left ventricular end-systolic volume index https://web.pathway.md/studies/recTUhh6qgdfkv8Wb 1/2 6/27/23, 11:44 PM BLOCK-HF Pathway 55.6 % 55.6 45.8 41.7 % 27.8 % 13.9 % Borderline significant decrease 0.0 % Biventricular pacing Conventional right ventricular pacing Borderline significant decrease in death, urgent care visit for HF, or 15% elevation in the LV end-systolic volume index (45.8% vs. 55.6%; HR 0.74, 95% CI 0.6 to 0.9) Safety outcomes Significant difference in LV lead-related complications (6.4%). Conclusion In patients with AV block with NYHA class I-III HF and LVEF 50%, biventricular pacing was superior to conventional RV pacing with respect to death, urgent care visit for HF, or 15% elevation in the LV end-systolic volume index. Reference Curtis AB, Worley SJ, Adamson PB et al. Biventricular pacing for atrioventricular block and systolic dysfunction. N Engl J Med. 2013 Apr 25;368(17):1585-93. Open reference URL https://web.pathway.md/studies/recTUhh6qgdfkv8Wb 2/2