What is the efficacy of antithrombotic therapy in chronic heart failure?
The efficacy of antithrombotic therapy in chronic heart failure has been studied in several clinical trials. The HELAS study found that antithrombotic therapy was effective in reducing the risk of mortality in patients with chronic heart failure. The WARCEF trial found that warfarin combined with aspirin was more effective than aspirin alone in reducing the risk of stroke and death in patients with chronic heart failure and sinus rhythm. The WATCH study found that warfarin, aspirin, and clopidogrel were all effective in reducing mortality in patients with chronic heart failure. Finally, the COMMANDER HF trial found that rivaroxaban was more effective than vitamin K antagonists in reducing the risk of death and stroke in patients with heart failure, sinus rhythm, and coronary disease.