What is the effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes?
The UK Prospective Diabetes Study (UKPDS) Group conducted a study in 1998 that found that intensive blood-glucose control with metformin had a beneficial effect on reducing complications in overweight patients with type 2 diabetes. Subsequent studies, such as the PRO-active Study (2005), the American Diabetes Association and the American College of Cardiology Foundation and the American Heart Association's position statement (2009), the systematic review by Kelly et al. (2009), the randomized controlled trial by Selvin et al. (2008), and the meta-analysis by Ray et al. (2009) have all found that intensive glucose control can reduce the risk of macrovascular events and cardiovascular disease in type 2 diabetes patients. The retrospective cohort study by Currie et al. (2010) and 10-year follow-up study by Holman, et al. (2008) also found that intensive glucose control can increase survival in type 2 diabetes patients. 