What are the potential harms of concomitant use of ACE inhibitors and ARNI?
Available evidence demonstrates a potential signal of harm for a concomitant use of ACE inhibitors and ARNI. The potential harms include hypotension and a low-frequency incidence of angioedema. Additionally, ACE inhibitors and ARNI should not be administered concomitantly or within 36 hours of the last dose of an ACE inhibitor.