What are the benefits of combining ACE-Is and ARBs with diuretics for the treatment of high BP?
The antihypertensive and anti-albuminuric effects of ACE-Is and ARBs are complemented by dietary sodium restriction or administration of diuretics. Co-administration of beta-blockers and calcium-channel blockers with ACE-Is or ARBs is also acceptable. One recent post hoc analysis of a large trial involving hypertensive individuals demonstrated that a combination of an ACE-I (benazepril) and calcium antagonist (amlodipine) was superior to the same ACE-I used with a diuretic (hydrochlorothiazide) in slowing CKD progression. This combination of ACE-Is and/or ARBs with diuretics is beneficial in the treatment of high BP as it provides antihypertensive and anti-albuminuric effects as well as slowing CKD progression.