6/28/23, 10:13 PM Effect of Vitamin D on psoriasis severity Pathway Feedback Search Clinical Topics Home Studies Effect of Vitamin D on psoriasis severity Effect of Vitamin D on psoriasis severity Disease Psoriasis Trial question What is the effect of vitamin D supplementation on psoriasis severity in patients with lower-range serum 25-hydroxyvitamin D levels? Study design Single center Double blinded RCT Population Characteristics of study participants 38.0% female N = 122 62.0% male 122 patients (46 female, 76 male) Inclusion criteria: adults with active plaque psoriasis and 25-hydroxyvitamin D levels < 24 ng/mL Key exclusion criteria: nut allergy; primary hyperparathyroidism; granulomatous diseases; pregnancy; clinical signs of proximal myopathy Interventions N=60 vitamin D (cholecalciferol oral capsules, 100,000 IU loading dose, followed by 20,000 IU per week for 4 months) N=62 placebo (matching placebo oral capsules for 4 months) Primary outcome Reduction in psoriasis area severity index score 0.4 0.41 https://web.pathway.md/studies/reczogDJDo1RbJ6CY 1/2 6/28/23, 10:13 PM Effect of Vitamin D on psoriasis severity Pathway 0.34 0.3 0.2 0.1 No significant difference 0.0 Vitamin D Placebo No significant difference in reduction in psoriasis area severity index score (0.34 vs. 0.41; AD -0.11, 95% CI -0.45 to 0.23) Secondary outcomes No significant difference in reduction in self-administered psoriasis area severity index (0.5 vs. -0.25; AD 0.6, 95% CI -0.55 to 1.76) No significant difference in improvement in DLQI (-0.59 vs. 0.1; AD -0.86, 95% CI -1.9 to 0.19) No significant difference in improvement in physical global assessment score of 1 (8.5% vs. 11.5%; OR 0.66, 95% CI 0.27 to 1.63) Conclusion In adults with active plaque psoriasis and 25-hydroxyvitamin D levels < 24 ng/mL, vitamin D was not superior to placebo with respect to reduction in psoriasis area severity index score. Reference Marita Jenssen, Anne-Sofie Furberg, Rolf Jorde et al. Effect of Vitamin D Supplementation on Psoriasis Severity in Patients With Lower-Range Serum 25-Hydroxyvitamin D Levels: A Randomized Clinical Trial. JAMA Dermatol. 2023 Mar 29;e230357. Open reference URL https://web.pathway.md/studies/reczogDJDo1RbJ6CY 2/2