What is the relationship between insulin resistance and stroke risk among nondiabetic individuals?
Several studies have found a positive correlation between insulin resistance and stroke risk in nondiabetic individuals. For example, the Northern Manhattan Study and the Honolulu Heart Program found that insulin resistance increased an individual's risk of developing ischemic stroke. Additionally, the DECODE Study Group found that hyperglycemia increases an individual's risk of both ischemic and hemorrhagic stroke. Finally, the Diabetes Surgery Study found that Roux-en-Y gastric bypass surgery, which has been associated with improved glucose metabolism, reduced the risk of type 2 diabetes, hypertension, and hyperlipidemia.