What is the mechanism of action for Transmyocardial Revascularization (TMR)?
TMR has been used as either a percutaneous or a surgical procedure concomitant with CABG or as sole therapy in patients with angina refractory to medical therapy. Proposed mechanisms of action include stimulation of microcirculation, creation of myocardial scarring, and denervation of ischemic myocardium. Various energy sources have been used, including carbon dioxide XeCl excimer and holmium:YAG lasers. There is no convincing evidence that one energy source is superior to the others.