6/28/23, 11:44 PM O2-ICU Pathway Feedback Search Clinical Topics Home Studies O2 ICU O2 ICU Trial question Is conservative oxygen therapy superior to conventional oxygen therapy in critically ill patients? Study design Single center Open label RCT Population Characteristics of study participants 43.0% female N = 434 57.0% male 434 patients (188 female, 246 male) Inclusion criteria: adult patients admitted to the ICU with an expected length of stay 72 hours Key exclusion criteria: readmission to ICU; decision to withhold life-sustaining treatment; immunosuppression or neutropenia; enrollment in other prospective studies Interventions N=216 conservative oxygen therapy (lowest possible FiO2 partial pressure of oxygen between 70 and 100 mmHg or SpO2 between 94% and 98%) N=218 conventional oxygen therapy (partial pressure of oxygen up to 150 mmHg or SpO2 > 97%) Primary outcome Death in intensive care unit 20.2 % 20.2 15.1 % 11.6 10.1 % Significant decrease 5.0 % https://web.pathway.md/studies/recesTQjmnafPy1Hy 1/2 6/28/23, 11:44 PM O2-ICU Pathway NNT = 12 0.0 % Conservative oxygen therapy Conventional oxygen therapy Significant decrease in death in the ICU (11.6% vs. 20.2%; RR 0.57, 95% CI 0.37 to 0.9) Secondary outcomes Significant decrease in the percentage of patients who developed shock (3.7% vs. 10.6%; RR 0.35, 95% CI 0.16 to 0.75) Significant decrease in the percentage of patients who developed liver failure (1.9% vs. 6.4%; RR 0.29, 95% CI 0.1 to 0.82) Significant decrease in bacteremia (5.1% vs. 10.1%; RR 0.5, 95% CI 0.25 to 1) Conclusion In adult patients admitted to the ICU with an expected length of stay 72 hours, conservative oxygen therapy was superior to conventional oxygen therapy with respect to death in the ICU. Reference Massimo Girardis, Stefano Busani, Elisa Damiani et al. Effect of Conservative vs Conventional Oxygen Therapy on Mortality Among Patients in an Intensive Care Unit: The Oxygen-ICU Randomized Clinical Trial. JAMA. 2016 Oct 18;316(15):1583-1589. Open reference URL https://web.pathway.md/studies/recesTQjmnafPy1Hy 2/2