What are the eligibility recommendations for IV alteplase in patients with AIS?
IV alteplase (0.9 mg/kg, maximum dose 90 mg over 60 min with initial 10% of dose given as bolus over 1 min) is recommended for selected patients who may be treated within 3 h of ischemic stroke symptom onset or patient last known well or at baseline state. Physicians should review the criteria outlined in this table to determine patient eligibility. (COR I; LOE A) Within 3 h Age For otherwise medically eligible patients 18 y of age, IV alteplase administration within 3 h is equally recommended for patients 80 and >80 y of age.