What is the effect of weight loss on vascular risk factors?
Weight loss of as little as 5% to 10% produces meaningful improvements in vascular risk factors.279 Only 1 trial has tested the effect of an intensive lifestyle intervention for weight loss on the prevention of vascular disease, and it was stopped early for futility.292 Inadequate average weight loss in the active treatment group and statin therapy in the control group might explain the negative findings.