What are the current recommendations for short-term use of DAPT with aspirin and clopidogrel?
The current recommendations for the short-term (21-90 days) use of DAPT with aspirin and clopidogrel are informed by two major randomized controlled trials (RCTs) and a systematic review by the American Heart Association (AHA) Evidence Review Committee. Both the CHANCE and POINT trials compared DAPT with SAPT with aspirin initiated early after onset of minor stroke or high-risk transient ischaemic attack, but varied in duration of DAPT treatment (21 and 90 days, respectively). The AHA Evidence Review Committee concluded that DAPT should be initiated within 24 hours of minor stroke or high-risk transient ischaemic attack and continued for 21-90 days.