What benefit does prasugrel provide compared to clopidogrel in patients with NSTE-ACS and defined coronary anatomy undergoing planned PCI?
In patients with NSTE-ACS and defined coronary anatomy undergoing planned PCI, a 60-mg loading dose of prasugrel followed by 10 mg daily was compared with a 300-mg loading dose and 75 mg daily of clopidogrel. The composite primary endpoint (cardiovascular death, nonfatal MI, and stroke) was reduced in patients treated with prasugrel (hazard ratio [HR]: 0.81; P=0.001). This was driven by a risk reduction for MI and stent thrombosis with no difference in mortality.