What data is available on the efficacy of loop diuretics in the treatment of high blood pressure with or without CKD?
There are no data on clinical outcomes with loop diuretics in the treatment of high BP with or without CKD. However, loop diuretics are often effective at lower GFRs (i.e., <30 ml/min per 1.73 m2 ) when combined with a thiazide diuretic. Thiazide diuretics also lose efficacy in diuresis and BP lowering as GFR worsens, but several, including chlorthalidone, metolazone, and indapamide appear to remain effective at lower GFRs.