6/27/23, 11:46 PM ACCORD BP Pathway Feedback Search Clinical Topics Home Studies ACCORD BP ACCORD BP Disease Disease Diabetes mellitus type 2 Hypertension Trial question What is the effect of intensive BP control in patients with T2DM mellitus at high risk for cardiovascular events? Study design Multi-center Open label RCT Population Characteristics of study participants 48.0% female N = 4733 52.0% male 4733 patients (2258 female, 2475 male) Inclusion criteria: patients with T2DM at high risk for cardiovascular events Key exclusion criteria: BMI > 45, a serum creatinine level > 1.5 mg/dL (132.6 mcmol/L), and other serious illness Interventions N=2362 intensive BP control (targeting a systolic pressure of < 120 mmHg) N=2371 standard BP control (targeting a systolic pressure of < 140 mmHg) Primary outcome Nonfatal myocardial infarction, nonfatal stroke, or death from cardiovascular causes https://web.pathway.md/studies/recDXR69kwZOLm4CN 1/2 6/27/23, 11:46 PM ACCORD BP Pathway 2.1 % 2.09 1.87 1.6 % 1.0 % 0.5 % No significant difference 0.0 % Intensive blood pressure control Standard blood pressure control No significant difference in nonfatal myocardial infarction, nonfatal stroke, or death from cardiovascular causes (1.87% vs. 2.09%; HR 0.88, 95% CI 0.73 to 1.06) Secondary outcomes No significant difference in annual death from any cause (1.28% vs. 1.19%; HR 1.07, 95% CI 0.85 to 1.35) Significant decrease in stroke at 1 year (0.32% vs. 0.53%; HR 0.59, 95% CI 0.39 to 0.89) Safety outcomes Significant differences in serious adverse events attributed to antihypertensive treatment (3.3% vs. 1.3%, p < 0.001). Conclusion In patients with T2DM at high risk for cardiovascular events, intensive BP control was not superior to standard BP control with respect to nonfatal myocardial infarction, nonfatal stroke, or death from cardiovascular causes. Reference ACCORD Study Group, Cushman WC, Evans GW et al. Effects of intensive blood-pressure control in type 2 diabetes mellitus. N Engl J Med. 2010 Apr 29;362(17):1575-85. Open reference URL https://web.pathway.md/studies/recDXR69kwZOLm4CN 2/2