What is the efficacy of statins in familial hypercholesterolemia?
Studies have shown that statins are effective in treating familial hypercholesterolemia. In a long-term cohort study by Versmissen et al. (2008), it was reported that patients with familial hypercholesterolemia who took statins had a decrease in their serum cholesterol levels. Furthermore, in a meta-analysis of data from 170000 patients by Baigent et al. (2010), it was found that more intensive lowering of low-density lipoprotein (LDL)-C was associated with a reduction in cardiovascular risk for different therapeutic interventions. Additionally, in a clinical trial by Kastelein et al. (2008), it was reported that simvastatin with or without ezetimibe reduced LDL-C levels in familial hypercholesterolemia patients. These findings suggest that statins are effective in treating familial hypercholesterolemia. 