What is the relationship between age at onset of menopause and cardiovascular outcomes?
A systematic review and meta-analysis by Muka et al. (2016) found that women who experienced an earlier onset of menopause were at an increased risk of cardiovascular outcomes, intermediate vascular traits, and all-cause mortality. Roeters van Lennep et al. (2016) also found that women with premature ovarian insufficiency were at a higher risk of cardiovascular disease. These findings suggest that an earlier onset of menopause is associated with an increased risk of cardiovascular outcomes. 