What antibiotics are recommended for treating NVE caused by MSSA or MRSA?
For patients with NVE caused by MSSA or MRSA, vancomycin is recommended, with daptomycin as a reasonable alternative for left-sided NVE caused by MRSA on the basis of limited data in a prospective, randomized trial; a multinational, prospective cohort investigation of the use of high-dose (9 mg/kg per dose) daptomycin; and a multicenter, retrospective, observational study that included daptomycin at 8 mg/kg per dose. Selection of daptomycin dosing should be assisted by infectious diseases consultation. At this time, additional study of ceftaroline is needed to define its role, if any, in the treatment of left-sided NVE caused by MRSA. 