What are the long-term risks of acute declines in renal function during intensive blood pressure lowering?
Research suggests that acute declines in renal function during intensive blood pressure lowering can increase the risk of death in the long term. A study by Ku et al. (2018) found that individuals who experienced acute declines in renal function during intensive blood pressure lowering had a significantly greater risk of death over the following 6 years, compared to individuals who did not experience such declines. Similarly, a study by Collard et al. (2018) found that individuals with type 2 diabetes mellitus who experienced a rise in creatinine during blood pressure therapy had an increased risk of adverse clinical outcomes in the long term.  