What recommendations exist regarding the timing of CABG with respect to clopidogrel, prasugrel, and ticagrelor?
The recommended timing of CABG for patients who have been taking clopidogrel is 5 days after discontinuation. For patients taking prasugrel, CABG should be delayed for 7 days after discontinuation. For patients taking ticagrelor, the study protocol recommends waiting 5 days after stopping clopidogrel and 24 to 72 hours after ticagrelor, although many patients underwent surgery before the recommended waiting times. The rates of major bleeding and transfusion requirements were similar for patients who underwent CABG within 7 days of the last dose of study drug with both ticagrelor and clopidogrel.