What were the outcomes of the LE MANS trial?
The outcomes at 30 days and 1 year of the LE MANS (Study of Unprotected Left Main Stenting Versus Bypass Surgery) trial were similar between the PCI and CABG groups. Although a low proportion of patients treated with PCI received DES (35%) and a low proportion of patients treated with CABG received IMA grafts (72%), there were no significant differences between the groups in terms of all-cause death, MACE, or stroke. At 3 years of follow-up, the incidence of death in those with a low or intermediate SYNTAX score was 3.7% after PCI and 9.1% after CABG (P 0.03), whereas in those with a high SYNTAX score the incidence of death after 3 years was 13.4% after PCI and 7.6% after CABG (P 0.10). The primary endpoint of SYNTAX, a noninferiority comparison of CABG and PCI, was not met. 