6/28/23, 10:33 PM FACTT Pathway Feedback Search Clinical Topics Home Studies FACTT FACTT Disease Acute respiratory distress syndr Trial question What is the effect of conservative fluid management strategy in patients with acute lung injury? Study design Multi-center Open label RCT Population Characteristics of study participants 53.5% female N = 1000 46.5% male 1000 patients (535 female, 465 male) Inclusion criteria: patients with acute lung injury Key exclusion criteria: acute lung injury > 48 hours; chronic conditions that could independently influence survival, severe lung or neuromuscular disease or dependence on dialysis; and advanced cancer Interventions N=503 conservative fluid use (conservative use of fluids) N=497 liberal fluid use (liberal use of fluids) Primary outcome Death at 60 days 28.4 % 28.4 25.5 21.3 % https://web.pathway.md/studies/recvgro7oCzzI73U9 1/2 6/28/23, 10:33 PM FACTT Pathway 14.2 % 7.1 % No significant difference 0.0 % Conservative fluid use Liberal fluid use No significant difference in death at 60 days (25.5% vs. 28.4%; RR 0.9, 95% CI -2.6 to 8.4) Secondary outcomes Significant increase in ventilator-free days (14.6 vs. 12.1; MD 2.5, 95% CI 1.02 to 3.98) Significant increase in ICU free days (13.4 vs. 11.2; ARD 2.2, 95% CI 0.89 to 3.51) Conclusion In patients with acute lung injury, conservative fluid use was superior to liberal fluid use with respect to death at 60 days. Reference National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network et al. Comparison of two fluid-management strategies in acute lung injury. N Engl J Med. 2006 Jun 15;354(24):2564-75. Open reference URL https://web.pathway.md/studies/recvgro7oCzzI73U9 2/2