What are the differences in the clinically effective molar concentrations of four direct thrombin inhibitors?
The differences in the clinically effective molar concentrations of four direct thrombin inhibitors explain their variable prothrombin time prolongation. According to a study published in the Thromb Haemost journal in 2005, Warkentin et al. concluded that these differences in molar concentrations can be attributed to differences in the pharmacokinetics and pharmacodynamics of the four direct thrombin inhibitors. These four direct thrombin inhibitors are argatroban, dabigatran, bivalirudin, and hirudin.