What is the role of empirical oral anticoagulation in patients with cardiomyopathy, reduced EF, and a history of stroke/TIA?
The role of empirical oral anticoagulation in patients with cardiomyopathy, reduced EF, and a history of stroke/TIA should be investigated further in future studies, as these patients were largely underrepresented in RCTs of prophylactic oral anticoagulation in patients with cardiomyopathies and reduced EF. Data from isolated case reports and small case series suggest that DOACs or low-molecular-weight heparin may be beneficial in these clinical scenarios, but larger-scale multicenter observational data will be necessary to clarify whether DOACs or low-molecular-weight heparin can be used safely and effectively in these patients.551