What is the utility of measuring natriuretic peptide biomarker levels during a HF hospitalization?
Measurement of natriuretic peptide biomarker levels during hospitalization can be useful in establishing a postdischarge prognosis. Studies have suggested that predischarge natriuretic peptide biomarker levels had higher reclassification and discrimination value than clinical variables in predicting outcomes. Patients with higher predischarge levels and patients who do not have a decrease in natriuretic peptide biomarker levels during hospitalization have worse outcomes. Clinical assessment and adherence to GDMT should be the emphasis, and the prognostic value of a predischarge value or relative changes does not imply the necessity for serial and repeated biomarker measurements during hospitalization.