What treatment regimens are recommended for native valve highly penicillin-susceptible VGS and S gallolyticus (bovis)?
Treatment regimens outlined for native valve highly penicillin-susceptible VGS and S gallolyticus (bovis) include parenteral penicillin or ceftriaxone for 4 weeks, with the addition of gentamicin sulfate to penicillin exerting a synergistic killing effect in vitro. Ampicillin is a reasonable alternative to penicillin and has been used when penicillin is not available due to supply deficiencies. Bacteriological cure rates of up to 98% may be anticipated in patients who complete the recommended course of therapy.  