What is the recommended antibiotic dose for native valve (community acquired) or late prosthetic valve (>1 y after surgery) infection?
The recommended antibiotic dose for native valve (community acquired) or late prosthetic valve (>1 y after surgery) infection is ampicillin/sulbactam plus gentamicin, IV divided every 4-6 h up to 12 g daily, or vancomycin (plus gentamicin) IV divided every 8-12 h up to 2 g daily. For prosthetic valve endocarditis, add rifampin IV divided every 4-6 h up to 12 g daily.