What is the purpose of the Carvedilol Or Metoprolol European Trial (COMET)?
The purpose of the Carvedilol Or Metoprolol European Trial (COMET) was to compare the effects of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure. The study was a randomized controlled trial which was published in the Lancet in 2003 and it found that carvedilol was more effective than metoprolol in improving clinical outcomes in patients with chronic heart failure.