What are the results of combining clopidogrel with aspirin in patients with stable ischemic heart disease (SIHD)?
In a meta-analysis of 5 randomized controlled trials (RCTs) comparing clopidogrel plus aspirin to aspirin alone in patients with IHD, the incidence of all-cause mortality, MI, and stroke was found to be reduced in the clopidogrel-plus-aspirin group, whereas the risk of major bleeding increased significantly. However, data on specific subgroups are lacking, and further research will be required to identify the ideal target population.