What are the benefits of treating LDL-C in children aged o10 years?
Data on the benefits of treating LDL-C in children aged o10 years are extremely limited, and chiefly include patients with severe familial hypercholesterolemia or cardiac allografts. Four randomized trials have examined drug treatment of dyslipidemia in children with CKD, primarily in children with nephrotic syndrome. These trials demonstrate that statins lower LDL-C over 7 months to 5 years. No randomized trials have studied clinically relevant outcomes such as cardiovascular events or mortality. There have been 13 statin trials in 1683 children with dyslipidemias and normal kidney function. These trials have demonstrated that statins lower LDL-C by 17-50% (depending on dose) and have modest effects on TGs or HDL-C.