What RCTs have directly compared PTAS with medical therapy in patients with symptomatic 50-69% stenosis?
No RCTs have directly compared PTAS with medical therapy in patients with symptomatic 50-69% stenosis. However, the low rate of stroke on medical therapy in patients with 50-69% high periprocedural risk, which does not vary by degree of stenosis,368 and lack of demonstrated benefit of PTAS in well-designed RCTs performed in a higher-risk population do not support the use of PTAS.