What is the effect of blood pressure lowering on major cardiovascular events according to baseline blood pressure?
A meta-analysis of randomized trials conducted by Czernichow et al. (2011) found that blood pressure lowering had significant effects on major cardiovascular events, regardless of baseline blood pressure. The Blood Pressure Lowering Treatment Trialists Collaboration (2014) also conducted a meta-analysis of individual patient data and found that blood pressure-lowering treatment based on cardiovascular risk had a beneficial effect on major cardiovascular events. Lastly, SPRINT (2015) conducted a randomized trial and found that intensive blood pressure control reduced the risk of major cardiovascular events compared to standard blood pressure control.