What evidence supports diuretic-based antihypertensive therapies as first-line therapy for preventing heart failure?
Diuretic-based antihypertensive therapies have been shown to prevent HF in a wide range of target populations as first-line therapy.27,35 39 Additionally, low-dose diuretics have been shown to be more effective as a first-line treatment for preventing the development of HF compared with ACE inhibitors, -blockers, or calcium channel blockers by meta-analysis. Most of the original trials used the longer-acting chlorthalidone rather than hydrochlorothiazide.