What is the evidence base for the recommendation to use intensive BP control in children with CKD?
The evidence base for the recommendation to use intensive BP control in children with CKD is primarily based on the Effect of Strict Blood Pressure Control and ACE Inhibition on the Progression of CKD in Pediatric Patients (ESCAPE) trial which showed a probable benefit in slowing kidney disease progression and no greater risk of adverse events, such as hypotension or acute decrease in GFR.