What is the recommended NT-proBNP level to refer a patient for echocardiography when heart failure is suspected in a patient presenting with signs and symptoms of heart failure in primary care?
The committee agreed to recommend that an NT-proBNP level of 400pg/ml be used to refer a patient for echocardiography when heart failure is suspected in a patient presenting with signs and symptoms of heart failure in primary care, based on the results of the economic analyses. The committee considered the base case analysis to be robust to changes in model assumptions and data inputs, however they acknowledged the uncertainty that remains for this question due to the inconsistencies in the study populations and diagnostic accuracy data across the studies assessed in the model.