What is the CADISS trial?
The CADISS (Cervical Artery Dissection in Stroke Study) was an open-label trial that randomized 250 patients with extracranial dissection within 7 days from symptom onset to receive either antiplatelets or anticoagulants in the following 3 months. At the 1-year follow-up, there was no difference in the primary end point of stroke or death between the two groups: 3.2% in the antiplatelet group versus 1.6% in the anticoagulant group (OR, 0.56 [95% CI, 0.05-5.5]). This trial supports that there is equipoise between antiplatelets and anticoagulants in the first 3 months after a cervical artery dissection. 