6/28/23, 11:22 PM NOTT Pathway Feedback Search Clinical Topics Home Studies NOTT NOTT Disease Disease Disease Chronic obstructive pulmonary Dyspnea in palliative care Home oxy Trial question What is the role of continuous oxygen therapy in patients with COPD and hypoxemia? Study design Multi-center Open label RCT Population Characteristics of study participants 2.5% female N = 203 97.5% male 203 patients (4 female, 160 male) Inclusion criteria: patients with COPD and hypoxemia Key exclusion criteria: previous oxygen therapy, other disease that might influence morbidity, mortality, compliance with therapy, or ability to give informed consent Interventions N=101 continuous oxygen therapy (by nasal prong at a measured flow rate of 1-4 L/min continuously for at least 12 months) N=102 nocturnal oxygen therapy (by nasal prong at a measured flow rate of 1-4 L/min at an interval of 12 hours for at least 12 months) Primary outcome https://web.pathway.md/studies/recSuwyvgh3TmeiBZ 1/2 6/28/23, 11:22 PM NOTT Pathway Death at 1 year 20.6 % 20.6 15.5 % 11.9 10.3 % Significant decrease 5.2 % NNT = 11 0.0 % Continuous oxygen therapy Nocturnal oxygen therapy Significant decrease in death at 1 year (11.9% vs. 20.6%; HR 0.52, 95% CI 0.31 to 0.85) Secondary outcomes Significant decrease in death, in patients with arterial partial pressure of CO2 43 mmHg (19.6% vs. 46%; RR 0.43, 95% CI 0.16 to 0.7) Conclusion In patients with COPD and hypoxemia, continuous oxygen therapy was superior to nocturnal oxygen therapy with respect to death at 1 year. Reference Nocturnal Oxygen Therapy Trial Group. Continuous or nocturnal oxygen therapy in hypoxemic chronic obstructive lung disease: a clinical trial. Nocturnal Oxygen Therapy Trial Group. Ann Intern Med. 1980 Sep;93(3):391-8. Open reference URL https://web.pathway.md/studies/recSuwyvgh3TmeiBZ 2/2