What is the recommended treatment for patients with atheroscle- rosis ipsilateral to the ischemic territory?
The recommended treatment for patients with atheroscle- rosis ipsilateral to the ischemic territory is a combination of ticagrelor 90 mg twice a day plus aspirin 100 mg once a day. In this prespecified subgroup analysis, risk of recurrent stroke or death at 30 days among patients with 30% intracranial stenosis ipsilateral to the ischemic event was 9.9% in the ticagrelor 90 mg twice a day plus aspirin 100 mg once a day group versus 15.2% in the aspirin 100 mg alone group (HR, 0.66 [95% CI, 0.47 0.93]; P=0.016). Of note, THALES required loading doses of both ticagrelor and aspirin. 