6/30/23, 12:37 AM VIOLET (lung cancer) Pathway Feedback Search Clinical Topics Home Studies VIOLET (lung cancer) VIOLET (lung cancer) Disease Disease Non-small cell lung cancer Small cell lung cancer Trial question Is video-assisted thoracoscopic surgery superior to open surgery in patients with early-stage lung cancer? Study design Multi-center Single blinded RCT Population Characteristics of study participants 50.0% female N = 502 50.0% male 502 patients (253 female, 249 male) Inclusion criteria: patients with early-stage lung cancer Key exclusion criteria: previous malignancy influencing life expectancy; planned pneumonectomy or non-anatomic resection; serious concomitant disorder compromising patient safety during surgery; planned robotic surgery Interventions N=247 VATS lobectomy (video-assisted thoracoscopic surgery) N=255 open lobectomy (conventional open surgery) Primary outcome Improvement in physical function at week 28 73.0 73 67 54 8 https://web.pathway.md/studies/recnyef3Pb9FqeGzX 1/2 6/30/23, 12:37 AM VIOLET (lung cancer) Pathway 54.8 36.5 18.3 Significant increase 0.0 VATS lobectomy Open lobectomy Significant increase in improvement in physical function at week 28 (73 vs. 67; MD 4.65, 95% CI 1.69 to 7.61) Secondary outcomes Significant decrease in pain score at day 2 post-op (3 vs. 4; MD -0.54, 95% CI -0.99 to -0.09) Safety outcomes No significant difference in serious adverse events in hospital. Significant differences in adverse events in hospital (32.8% vs. 44.3%), serious adverse events after discharge (30.7% vs. 37.8%). Conclusion In patients with early-stage lung cancer, VATS lobectomy was superior to open lobectomy with respect to improvement in physical function at week 28. Reference Eric Lim, F.R.C.S. (C-Th), Tim J.P. Batchelor et al. Video-Assisted Thoracoscopic or Open Lobectomy in Early-Stage Lung Cancer. NEJM Evid. 2022;1(3). Open reference URL https://web.pathway.md/studies/recnyef3Pb9FqeGzX 2/2