What is the SAMe-TT2R2 score?
The SAMe-TT2R2 score is a clinical score based on routine clinical parameters that can be used to identify patients who may be able to attain good anticoagulation control with a VKA and those who probably will not, where an NOAC may be preferred or where other interventions such as more frequent INR monitoring, patient education/counseling may need to be implemented to ensure good INR control. It has been assessed in 15 exclusively AF cohorts, reporting its predictive ability to forecast good or poor anticoagulation control, with c-statistics ranging from 0.54 to 0.91. The SAMe-TT2R2 score has been tested in multi-ethnic non-white Singaporean population by Bernaitis et al, and it was able to dichotomize the patients likely to do well on VKA, compared with those (score > 2) more likely to achieve poor TTR.  