What is the anticipated absolute effect on renal function with mineralocorticoid receptor antagonist?
The anticipated absolute effect on renal function with mineralocorticoid receptor antagonist can be determined by looking at the relative effect, risk with placebo, and risk difference with mineralocorticoid receptor antagonist. The relative effect, assessed with GRADE, was LOW due to risk of bias and inconsistency. The risk with placebo was from 12 more to 145 more, and the risk difference with mineralocorticoid receptor antagonist was from 58 more to 157 more. The mean renal function in the control groups was not stated, but in the intervention groups it was 221. This indicates that the anticipated absolute effect on renal function with mineralocorticoid receptor antagonist is likely to be moderate. 