What were the results of the Japanese Trial to Assess Optimal Systolic Blood Pressure in Elderly Hypertensive Patients (JATOS) study?
The Japanese Trial to Assess Optimal Systolic Blood Pressure in Elderly Hypertensive Patients (JATOS) randomized 4418 patients with essential hypertension aged 65 to 85 years with a systolic BP 4160 mm Hg to strict BP control (target systolic BP o140 mm Hg) or mild BP control (target systolic BP 145.6 11.1 in the mild-control group (Po0.001), with significantly more drugs required in the strict-control group. There was no difference in cerebrovascular, cardiac, or kidney end points, nor in total mortality between the two groups at 2 years of follow-up. Renal failure occurred in 8 and 9 patients, respectively. Rates of treatment withdrawal due to adverse events did not differ between the groups. 