What evidence is there for the use of statins to reduce the incidence and ischemic consequences of aSAH-induced vasospasm?
Several recent clinical trials have investigated the utility of statins, endothelin-1 antagonists, and magnesium sulfate. Statin agents have been studied in several small, single-center randomized trials with variable results. Although a recent meta-analysis reported no evidence for clinical benefit,219 a larger phase 3 trial (SimvasTatin in Aneurysmal Subarach- noid Hemorrhage [STASH]) is in progress. 