What is the relationship between AHRE and stroke risk? 
Studies have found that an AHRE burden of 5.5 hours in a day, over a 30-day period, was associated with a twofold increase in the adjusted risk of stroke. Integration of AHRE presence, duration, or burden into risk scores for thromboembolism may modestly improve c-statistics of both the CHADS2 and CHA2DS2-VASc scores for predicting stroke. However, the actual rates of stroke or systemic embolic events reported in studies evaluating CIED-detected AHREs are often lower than what would be predicted by CHADS2 and CHA2DS2-VASc scores, which may be related to concurrent treatment with OACs in each study, risk of under-reporting, and confounding. Additionally, the temporal relationship between ischemic stroke and AF is less strict than expected, since stroke may occur without the concurrent presence of atrial tachyarrhythmias or AF at the time of stroke or in the days before. 