What are the benefits and harms of replacing iron with intravenous iron in people with heart failure?
Replacing iron with intravenous iron in people with heart failure has the potential to quickly improve their quality of life, and potentially have an effect on HF pathophysiology. However, the committee noted that the trials had only included people with reduced ejection fraction, and it was decided that it would not be possible to generalise the evidence in these trials to people with HFPEF, as the patholophysiology differs, and therefore the balance of benefits and harms may be different. The committee were aware of a clinical trial which was currently active and included people with HFpEF which will provide further data on the benefits and harms associated with intravenous iron replacement for heart failure.