What are the potential cardioprotective effects of propofol during cardiopulmonary bypass?
Propofol has been found to have potential cardioprotective effects during cardiopulmonary bypass, such as reducing troponin T release in patients undergoing coronary artery bypass surgery (Jenkins et al., 1997), suppressing ventricular tachyarrhythmias after myocardial revascularization (Wu et al., 2002), and protecting against hydrogen peroxide-induced injury in cardiac H9c2 cells (Wang et al., 2009). Additionally, studies have shown that large doses of propofol reduce biochemical markers of myocardial injury in coronary surgery patients (Xia et al., 2006) and may preserve myocardial function in coronary surgery patients (De Hert et al., 2002). 