what are the Recommendations for Hydralazine and Isosorbide Dinitrate
Referenced studies that support the recommendations are summa-
rized in the Online Data Supplements.?
In patients with current or previous symp- tomatic HFrEF who cannot be given first-line agents, such as ARNi, ACEi, or ARB, because of drug intolerance or renal insufficiency, a combination of hydralazine and isosorbide dini- trate might be considered to reduce morbidity and mortality.