What are the nonspecific hemostatic agents used for NOAC reversal?
Nonspecific hemostatic agents used for NOAC reversal include prothrombin complex concentrates (PCCs), activated PCC, recombinant activated factor VII, and fresh-frozen plasma. PCCs are the preferred nonspecific hemostatic agent for NOAC reversal. PCCs are plasma-derived products that contain 3 (factors II, IX, and X) or 4 (addition of factor VII) clotting factors in addition to variable amounts of heparin and the natural coagulation inhibitors protein C and protein S.