What is a reasonable goal for initial BP reduction after AIS in patients with BP >220/120 mmHg?
Initial BP reduction by 15% is a reasonable goal for patients with BP >220/120 mmHg after AIS. Excessive drop in BP could result in complications such as stroke progression (by compromising cerebral perfusion in penumbral tissue) and acute kidney injury (from renal hypoperfusion). There are no data to show that one strategy to lower BP is better than another after AIS. The medications and doses in Table 5 are all reasonable options.