What laboratory measurements are recommended for NOACs?
The thrombin time (TT) is the most sensitive test for dabigatran; even low levels of dabigatran will prolong the TT so a normal TT excludes clinically relevant dabigatran concentrations. The dilute TT can be used to quantify dabigatran drug levels as it has good correlation across a wide range of dabigatran Chromogenic anti-factor Xa assays are recommended for rivaroxaban, apixaban, and edoxaban with calibration for the speci c agent.206 However, validation of these specialized coagulation tests is required, they are not universally available, and often have delayed turnaround time, which diminishes their usefulness in emergent situations.