What is the most cost effective NT-proBNP threshold for referral to echocardiography when diagnosing heart failure?
The analysis suggests that 400pg/ml is the most cost effective threshold for referring patients presenting to primary care with signs and symptoms of heart failure. 400pg/ml produces both the highest incremental QALYs and the highest incremental cost versus echo all, and has the highest net monetary benefit at 20,000 per QALY and is therefore the most cost effective diagnostic threshold for referral to echocardiography. The cost-effectiveness ratio of 400pg/ml versus 280pg/ml is 9,842. The probability of 400pg/ml being the most cost effective option at 20,000 per QALY is 62%.