What were the results of the Framingham Heart Study, Multiple Risk Factor Intervention trial, and the Lipid Research Clinics trials?
The Framingham Heart Study, Multiple Risk Factor Intervention trial, and the Lipid Research Clinics trials all found a continuous, graded increase in coronary events with increasing LDL cholesterol in men and women who were initially free of IHD.502,506 508 A similar relationship has been observed among patients with SIHD.509 511 The association between LDL cholesterol and cardiovascular risk is curvilinear, or log-linear, meaning that the decrease in RR for a given 1-mg/dL decrease in LDL cholesterol seems to be the same at any level of baseline LDL cholesterol.