6/28/23, 12:43 AM APTS Pathway Feedback Search Clinical Topics Home Studies APTS APTS Disease Disease Disease Preterm infant Preterm labor Umbilical Trial question Is delayed cord clamping superior to immediate cord clamping in preterm infants? Study design Multi-center Open label RCT Population Characteristics of study participants 44.0% female N = 1566 56.0% male 1566 patients (683 female, 883 male) Inclusion criteria: fetuses from women who were expected to deliver before 30 weeks of gestation Key exclusion criteria: fetal hemolytic disease; hydrops fetalis; twin-twin transfusion; genetic syndromes; potentially lethal malformations Interventions N=784 delayed cord clamping ( 60 seconds after delivery) N=782 immediate cord clamping ( 10 seconds after delivery) Primary outcome Death or major morbidity at 36 weeks of postmenstrual age 37.2 % 37.2 37 https://web.pathway.md/studies/recgtbxLkoEVLHkEz 1/2 6/28/23, 12:43 AM APTS Pathway 3 % 3 37 27.9 % 18.6 % 9.3 % No significant difference 0.0 % Delayed cord clamping Immediate cord clamping No significant difference in death or major morbidity at 36 weeks of postmenstrual age (37% vs. 37.2%; RR 1, 95% CI 0.88 to 1.13) Secondary outcomes Significant decrease in death at 36 weeks (6.4% vs. 9%; RR 0.69, 95% CI 0.49 to 0.97) No significant difference in death or severe brain injury (13.6% vs. 15.3%; RR 0.85, 95% CI 0.67 to 1.08) No significant difference in chronic lung disease (54.4% vs. 51.6%; RR 1.04, 95% CI 0.95 to 1.14) Conclusion In fetuses from women who were expected to deliver before 30 weeks of gestation, delayed cord clamping was not superior to immediate cord clamping with respect to death or major morbidity at 36 weeks of postmenstrual age. Reference William Tarnow-Mordi, Jonathan Morris, Adrienne Kirby et al. Delayed versus Immediate Cord Clamping in Preterm Infants. N Engl J Med. 2017 Dec 21;377(25):2445-2455. Open reference URL https://web.pathway.md/studies/recgtbxLkoEVLHkEz 2/2