What is the impact of calcium antagonist treatment on cyclosporine nephrotoxicity in renal transplantation?
Several clinical trials have demonstrated that calcium antagonist treatment of recipients minimizes early cyclosporine nephrotoxicity in renal transplantation. Studies have shown that calcium antagonist treatment can result in a better renal function after kidney transplantation, a reduction in the dose of cyclosporine required, and improved transplant outcomes. Furthermore, a long-term protective effect of a calcium antagonist on renal function in hypertensive renal transplant patients on cyclosporine therapy has been demonstrated in a 5-year prospective randomized study. Thus, calcium antagonist treatment may be an effective means of mitigating the nephrotoxic effects of cyclosporine in renal transplantation.  