What strategies are recommended for patients with CKD who require medications that increase the risk of drug toxicity when used with statins?
If medications that increase the risk of drug toxicity when used with statins are required in patients who are otherwise good candidates for statin treatment, physicians may consider one of two strategies. For medications that will be required only for short periods (such as an antibiotic), the statin could be temporarily discontinued. For medications that will be required for more than a few days, a switch to an alternative statin or reducing the statin dose could be considered to reduce the risk of drug toxicity. Additionally, the Work Group recommends that fibrates not be used concomitantly with statins in patients with CKD.