What is the guideline for downgrading the quality of evidence based on risk of bias and imprecision?
The quality of evidence is downgraded by one increment if the majority of the evidence is at high risk of bias, and downgraded by two increments if the majority of the evidence is at very high risk of bias. It is also downgraded by one increment as confidence interval crosses one MID or two increments as confidence interval crosses both MIDs.