What is the efficacy of homocysteine-lowering therapy with folic acid in stroke prevention?
The efficacy of homocysteine-lowering therapy with folic acid in stroke prevention has been studied in several randomized controlled trials, including the Vitamin Intervention for Stroke Prevention (VISP) trial, the Atherosclerosis and Folic Acid Supplementation Trial (ASFAST), and the Heart Outcomes Prevention Evaluation 2 (HOPE 2) trial. Results from these studies suggest that homocysteine-lowering therapy with folic acid may reduce the risk of cardiovascular events in patients with stroke, and may also reduce the severity of stroke-related disability.