What are the risk factors associated with abnormal transcranial Doppler ultrasonography in children with sickle cell anemia?
Alpha thalassemia, G6PD deficiency, absence of alpha-thalassemia, hemolytic rate at baseline, high reticulocyte count, age, hemoglobin, and aspartate transaminase have all been identified as risk factors for abnormal transcranial Doppler ultrasonography in children with sickle cell anemia. These risk factors have been found to increase the likelihood of abnormally high cerebral velocities in patients with sickle cell anemia. Additionally, early transcranial Doppler screening and intensive therapy have been found to have an impact on cerebral vasculopathy outcome in newborns with sickle cell anemia.  