What are the limitations of the Pulignano study?
The limitations of the Pulignano study include potentially serious limitations such as Spanish resource use data and unit costs (year not reported, assumed to be 2004) which may not reflect current NHS context, QALYs were not used as the health outcome measure, and within-trial analysis which does not reflect the full body of evidence available for this intervention. Additionally, Italian national health service resource use and unit costs may not reflect current UK NHS context, QALY data was not reported clearly enough to report and therefore were not used as the health outcome measure, discounting was not applied, and within-trial analysis which does not reflect the full body of evidence available for this comparison.