What were the thresholds used in the Zaphiriou study?
The test thresholds at which data was sought in the Zaphiriou study were 125pg/mL, 280 pg/mL and 400 pg/mL. These thresholds were selected based on the data already available in the included studies and to minimise the amount of additional data that needed to be collected, while still allowing for assessment of accuracy at key clinically relevant thresholds used in existing NICE guidelines and other international guidance.