What are the effects of lower BP targets in CKD patients older than 75 years?
A post hoc analysis of that specific subgroup in SPRINT showed that the low BP target (SBP <120 mm Hg) reduced the primary CV outcome (HR: 0.64; 95% CI: 0.45 0.92), all-cause death (HR: 0.64; 95% CI: 0.43 0.96), and the composite of primary CV disease outcome or all-cause death (HR: 0.66; 95% CI: 0.49). There was no description of potential harm of achieving lower targets in this subgroup of older adults with CKD, although the risk benefit ratio in the entire CKD cohort and in the entire subcohort older than 75 years in SPRINT was favorable. Even in the age group 80 years and older, subgroup analysis in SPRINT showed that intensive BP lowering decreased the risk of CV events (HR: 0.66; 95% CI: 0.53 0.81).