What is the effect of lowering LDL cholesterol with statin therapy on people at low risk of vascular disease?
A meta-analysis of individual data from 27 randomised trials found that lowering LDL cholesterol with statin therapy had a positive effect on people at low risk of vascular disease, as evidenced by a decrease in the risk of cardiovascular events. This was supported by the results of the MEGA Study, which found that primary prevention of cardiovascular disease with pravastatin in Japan was effective in reducing the risk of cardiovascular events.  