What factors should be taken into account when interpreting the results of repeat stress testing in patients with known CAD?
When interpreting the results of repeat stress testing in patients with known CAD, factors such as differences in day-to-day operations in the same laboratory, interobserver variability, and differences between practices in different imaging laboratories should be taken into account. Additionally, a 5% change in the percent of ischemic myocardium (based on extent and severity) has been suggested by some investigators as a threshold that indicates clinically significant change for stress nuclear MPI. Moreover, it is important to use the same imaging modality over time whenever possible.