What are the effects of regional differences in Asia on the efficacy and safety of edoxaban compared to warfarin?
The effects of regional differences in Asia on the efficacy and safety of edoxaban compared to warfarin were studied in the ENGAGE AF-TIMI 48 Trial. This study found that the efficacy and safety of edoxaban was comparable to warfarin in Asia. However, it was noted that there were some differences in the efficacy and safety of edoxaban in different Asian countries, which were primarily due to differences in patient characteristics, such as age and gender. Additionally, the study found that the dose of edoxaban needed to be adjusted in some Asian countries in order to achieve optimal efficacy and safety. Overall, the study concluded that the efficacy and safety of edoxaban is comparable to warfarin in Asia, although differences may exist between countries.  