Guideline sources The following summarized guidelines for the evaluation and management of ICU-acquired weakness are prepared by our editorial team based on guidelines from the American Association for Thoracic Surgery (AATS 2014). 1 Guidelines 1. Classification and risk stratification Risk factors for poor recovery: clinical research is required to determine the role of prior patient disability in the development of and recovery from ICU-acquired weakness. B 2. Nonpharmacologic interventions Physical rehabilitation: well-designed, adequately powered and executed RCTs are recommended to compare physical rehabilitation or other alternative treatments with usual care in patients with ICU-acquired weakness that measure and report patient-important outcomes. B 3. Patient education General counseling: clinical research is required to determine whether or not patients would want to know if they have ICU-acquired weakness, even though no specific therapy currently exists, https://web.pathway.md/diseases/recWpDfd4u1JnXtoH 1/2 6/24/23, 2:27 PM ICU-acquired weakness Pathway and how patient preferences influences medical decision making or the perception of prognosis. B References 1. Fan E, Cheek F, Chlan L et al. An official American Thoracic Society Clinical Practice guideline: the diagnosis of intensive care unit-acquired weakness in adults. Am J Respir Crit Care Med. 2014 Dec 15;190 12 1437 46. Open 2. Eddy Fan, Fern Cheek, Linda Chlan et al. An official American Thoracic Society Clinical Practice guideline: the diagnosis of intensive care unit-acquired weakness in adults. Am J Respir Crit Care Med. 2014 Dec 15;190 12 1437 46. Open 3. Naeem A Ali, James M O'Brien Jr, Stephen P Hoffmann et al. Acquired weakness, handgrip strength, and mortality in critically ill patients. Am J Respir Crit Care Med. 2008 Aug 1;178 3 261 8. Open 4. Sarah E Jolley, Aaron E Bunnell, Catherine L Hough. ICU Acquired Weakness. Chest. 2016 Nov;150 5 1129 1140. Open 5. Greet Hermans, Greet Van den Berghe. Clinical review: intensive care unit acquired weakness. Crit Care. 2015 Aug 5;19 1 274. Open https://web.pathway.md/diseases/recWpDfd4u1JnXtoH 2/2