What is the optimal NT-proBNP threshold for the diagnosis of heart failure in people with atrial fibrillation?
The optimal NT-proBNP threshold for the diagnosis of heart failure in people with atrial fibrillation is 400 ng/ml. This has been determined by research into the relative values of different outcomes. The investigation into BNP and NT-proBNP in the diagnosis of heart failure was approached by considering both clinical effectiveness and diagnostic accuracy. Within each approach, evidence was sought separately for the general suspected heart failure population, as well as people with atrial fibrillation (AF) and suspected heart failure, and people with chronic kidney disease (CKD) and suspected heart failure.