what are the Recommendations for Anticoagulation for Pregnant Women With
Mechanical Prosthetic Heart Valves
Referenced studies that support the recommendations are
summarized in Online Data Supplement 44.?
Pregnant women with mechanical valve prostheses who are on warfarin should switch to twice-daily LMWH (with a target anti-Xa level of 0.8 U/mL to 1.2 U/mL at 4 to 6 hours after dose) or intravenous UFH (with an activated partial thromboplastin time [aPTT] 2 times control) at least 1 week before planned delivery.