6/28/23, 12:52 AM Atan Pathway Feedback Search Clinical Topics Home Studies Atan Atan Disease Acute kidney injury Trial question What is the role of continuous venovenous hemofiltration-high cutoff in critically ill patients with AKI? Study design Single center Double blinded RCT Population Characteristics of study participants 41.8% female N = 76 58.2% male 76 patients (31 female, 43 male) Inclusion criteria: patients in the ICU with AKI who were vasopressor-dependent Key exclusion criteria: age < 18 years, suspected death within 24 hours by the treating clinician, previous treatment with hemofiltration or another dialysis during the same hospital admission, maintenance dialysis prior to admission or pregnant or breastfeeding Interventions N=36 continuous venovenous hemofiltration-high cutoff (polyethersulfone high cutoff filter with nominal cutoff point of 100 kDa) N=38 continuous venovenous hemofiltration-standard (custom manufactured polyethersulfone standard hemofilter with nominal cutoff point of 30 kDa) https://web.pathway.md/studies/rec2hpgBgJPGdCyoP 1/2 6/28/23, 12:52 AM Atan Pathway Primary outcome Norepinephrine-free time over 7 days 56.0 hours 56 42.0 hours 32 28.0 hours 14.0 hours No significant difference 0.0 hours Continuous venovenous hemofiltration-high cutoff Continuous venovenous hemofiltration-standard No significant difference in norepinephrine-free time over 7 days (32 hours vs. 56 hours; AD -24 hours, 95% CI -95.32 to 47.32) Secondary outcomes No significant difference in death in the ICU (50% vs. 31.6%; OR 2.17, 95% CI 0.84 to 5.58) No significant difference in death in the hospital (55.6% vs. 34.2%; OR 2.4, 95% CI 0.94 to 6.15) No significant difference in dose of intravenous albumin given over the first 7 days (90 grams vs. 80 grams; AD 10 grams, 95% CI -6.94 to 26.94) Safety outcomes No significant differences in time to cessation of norepinephrine, time to cessation of hemofiltration, filter life, serum albumin levels, time to death. Conclusion In patients in the ICU with AKI who were vasopressor-dependent, continuous venovenous hemofiltration-high cutoff was not superior to continuous venovenous hemofiltration-standard with respect to a norepinephrine-free time over 7 days. Reference Rafidah Atan, Leah Peck, John Prowle et al. A Double-Blind Randomized Controlled Trial of High Cutoff Versus Standard Hemofiltration in Critically Ill Patients With Acute Kidney Injury. Crit Care Med. 2018 Oct;46(10):e988-e994. Open reference URL https://web.pathway.md/studies/rec2hpgBgJPGdCyoP 2/2