What is the role of protease inhibitors in causing hyperlipidemia and insulin resistance in patients with HIV infection?
Mulligan et al. (2000) found that protease inhibitors can induce hyperlipidemia and insulin resistance in patients with HIV infection, independent of changes in body composition. This study showed that protease inhibitors can increase the risk of cardiovascular disease in HIV-positive patients, and that they should be monitored closely to prevent further complications.