What is the effect of angiotensin neprilysin inhibition (ANrI) versus enalapril in heart failure patients?
The SOLVD Investigators found that enalapril reduced mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions. McMurray et al. (2014) also found that ANrI was better than enalapril in reducing mortality and hospitalization due to heart failure in patients with clinical signs of heart failure.  Additionally, they found that ANrI had improved outcomes in terms of quality of life, exercise capacity, and echocardiographic parameters.