What is the recommended timing for anticoagulation in AF patients with acute ischemic stroke?
In AF patients with acute ischemic stroke, we recommend that long-term oral anticoagulation is indicated as secondary prevention (Strong recommendation, high quality evidence). The optimal timing of anticoagulation early after acute ischemic stroke is unknown, but oral anticoagulation should usually be started within 2 weeks of acute ischemic stroke. Early use of NOACs shows promise but requires testing in randomized controlled trials.