What evidence is used to grade the recommendation that children with CKD should have their blood pressure monitored?
The evidence used to grade the recommendation that children with CKD should have their blood pressure monitored includes observational data showing that those with hypertension (i.e., BP above the 95th percentile) have a more rapid decline in estimated GFR than those without hypertension, a study by the European Study Group of Nutritional Treatment of Chronic Renal Failure in Childhood, preliminary data from the ongoing observational Chronic Kidney Disease in Children (CKiD) study, and the kidney survival rate from the ESCAPE trial. On the basis of this evidence, the Work Group graded this recommendation as 1C, with the quality of evidence graded as C because the RCT evidence is limited to inferred evidence from one trial.