Guideline sources The following summarized guidelines for the management of platelet transfusion are prepared by our editorial team based on guidelines from the European Society of Intensive Care Medicine (ESICM 2020) and the American Association of Blood Banks (AABB 2015). 1 2 Guidelines 1. Medical management Indications for platelet transfusion: Transfuse platelets prophylactically to reduce the risk for spontaneous bleeding in hospitalized adult patients with therapy-induced hypoproliferative thrombocytopenia. B Transfuse platelets prophylactically to hospitalized adult patients with a platelet count 10 10 cells/L to reduce the risk for spontaneous bleeding. B 2. Specific circumstances Patients undergoing cardiopulmonary bypass: Avoid routine prophylactic platelet transfusion for patients who are not thrombocytopenic undergoing cardiac surgery with cardiopulmonary bypass. D Consider platelet transfusion for patients undergoing cardiopulmonary bypass who exhibit perioperative bleeding with thrombocytopenia and/or evidence of platelet dysfunction. C Critically ill patients, non-bleeding: avoid administering platelet transfusion to treat thrombocytopenia unless the platelet count falls < 10 10 /L. D Show 3 more https://web.pathway.md/diseases/recqVzuboDESe1Owa 1/2 6/29/23, 11:15 PM Platelet transfusion Pathway Show 3 more Studies 2015 PROPPR In patients with severe trauma and major bleeding who were predicted to receive a massive transfusion, 1:1:1 was not superior to 1:1:2 with respect to death from all causes at 24 hours. John B Holcomb et al. JAMA. 2015 Feb 3. References 1. Kaufman RM, Djulbegovic B, Gernsheimer T et al. Platelet transfusion: a clinical practice guideline from the AABB. Ann Intern Med. 2015 Feb 3;162 3 205 13. Open 2. Alexander P Vlaar, Simon Oczkowski, Sanne de Bruin et al. Transfusion strategies in non-bleeding critically ill adults: a clinical practice guideline from the European Society of Intensive Care Medicine. Intensive Care Med. 2020 Apr;46 4 673 696. Open 3. Schiffer CA, Bohlke K, Delaney M et al. Platelet Transfusion for Patients With Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update. J Clin Oncol. 2018 Jan 20;36 3 283 299. Open 4. Alexander P J Vlaar, Joanna C Dionne, Sanne de Bruin et al. Transfusion strategies in bleeding critically ill adults: a clinical practice guideline from the European Society of Intensive Care Medicine. Intensive Care Med. 2021 Dec;47 12 1368 1392. Open 5. Charles A Schiffer, Kari Bohlke, Meghan Delaney et al. Platelet Transfusion for Patients With Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update. J Clin Oncol. 2018 Jan 20;36 3 283 299. Open https://web.pathway.md/diseases/recqVzuboDESe1Owa 2/2