What is the recommended treatment for IE caused by non-HACEK Gram-negative aerobic bacilli?
The recommended treatment for IE caused by non-HACEK Gram-negative aerobic bacilli is cardiac surgery in combination with prolonged courses of combined antibiotic therapy. Prospective trial data are lacking to define the optimal antimicrobial regimen, so input from specialists in infectious diseases who are experienced in the medical management of IE should be obtained to define an antibiotic regimen in each case. 