What is Statin-associated muscle symptoms (SAMS) Myalgias?
SAMS Myalgias is a statin-associated side effect affecting about 1% to 5% of individuals in randomized clinical trials (RCTs) and 5% to 10% in observational studies and clinical settings. It is characterized by pain or aches in the muscle, in the absence of other findings, and may be more likely to be statin-associated if it is bilateral, involves proximal muscles, has its onset within weeks to months after statin initiation, and resolves after discontinuation of statins.