What are the benefits of ARBs for patients with HFrEF?
ARBs have been shown to reduce mortality and HF hospitalizations in patients with HFrEF in large RCTs.134 137 Long-term therapy with ARBs in patients with HFrEF produces hemodynamic, neurohormonal, and clinical effects consistent with those expected after interference with the renin-angiotensin system.145,146 Unlike ACE inhibitors, ARBs do not inhibit kininase and are associated with a much lower incidence of cough and angioedema, although kininase inhibition by ACE inhibitors may produce beneficial vasodilatory effects.