6/29/23, 1:45 AM Pulmonary artery catheters for acute lung injury Pathway Feedback Search Clinical Topics Home Studies Pulmonary artery catheters for acute lung injury Pulmonary artery catheters for acute lung injury Disease Acute respiratory distress syndr Trial question What is the role of pulmonary artery catheter-guided treatment in patients with established acute lung injury? Study design Multi-center Single blinded RCT Population Characteristics of study participants 46.5% female N = 1000 53.5% male 1000 patients (465 female, 535 male) Inclusion criteria: patients with established acute lung injury Key exclusion criteria: acute lung injury > 48 hours, dependence on dialysis, severe lung or neuromuscular disease, advanced cancer Interventions N=513 pulmonary artery catheter-guided resuscitation N=487 central venous catheter-guided resuscitation Primary outcome Survival at 60 days https://web.pathway.md/studies/recFPXEojmv5YYcn8 1/2 6/29/23, 1:45 AM Pulmonary artery catheters for acute lung injury Pathway 27.4 % 27.4 26.3 20.5 % 13.7 % 6.8 % No significant difference 0.0 % Pulmonary artery catheter-guided resuscitation Central venous catheter-guided resuscitation No significant difference in survival at 60 days (27.4% vs. 26.3%; AD 1.1%, 95% CI -4.4 to 6.6) Secondary outcomes No significant difference in the number of ventilator free days (13.2 vs. 13.5; AD -0.3, 95% CI -1.33 to 0.73) Safety outcomes No significant differences in complications-related adverse events (0.08 vs. 0.06 per catheter inserted, p=0.35). Significant difference in arrhythmias (42 vs. 7). Conclusion In patients with established acute lung injury, pulmonary artery catheter-guided resuscitation was not superior to central venous catheter-guided resuscitation with respect to survival at 60 days. Reference National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network et al. Pulmonary-artery versus central venous catheter to guide treatment of acute lung injury. N Engl J Med. 2006 May 25;354(21):2213-24. Open reference URL https://web.pathway.md/studies/recFPXEojmv5YYcn8 2/2