6/27/23, 11:48 PM BaSICS Pathway Feedback Search Clinical Topics Home Studies BaSICS BaSICS Disease Acute kidney injury Trial question Is a balanced solution superior to 0.9% saline solution in critically ill patients requiring fluid challenges? Study design Multi-center Double blinded RCT Population Characteristics of study participants 44.0% female N = 10520 56.0% male 10520 patients (4650 female, 5870 male) Inclusion criteria: critically ill patients requiring fluid administration with 1 risk factors for worse outcomes Key exclusion criteria: AKI treated or expected to require RRT within the next 6 hours, severe electrolyte disturbance, imminent death within 24 hours, brain death, receipt of palliative care Interventions N=5522 balanced solution (Plasma-Lyte) N=5530 saline solution (0.9% sodium chloride) Primary outcome Deaths at day 90 27.2 % 27.2 26.4 20 4 % https://web.pathway.md/studies/rec39fjNmuU1GSrw9 1/2 6/27/23, 11:48 PM 20.4 % BaSICS Pathway 13.6 % 6.8 % No significant difference 0.0 % Balanced solution Saline solution No significant difference in deaths at day 90 (26.4% vs. 27.2%; aHR 0.97, 95% CI 0.9 to 1.05) Secondary outcomes No significant difference in need for RRT in the hospital (7.5% vs. 8.1%; OR 0.93, 95% CI 0.81 to 1.06) No significant difference in AKI with KDIGO stage 2 at day 7 (23.4% vs. 23.3%; OR 1.07, 95% CI 0.88 to 1.3) No significant difference in hospital length of stay (8 days vs. 9 days; AD -0.3 days, 95% CI -1.1 to 0.5) Conclusion In critically ill patients requiring fluid administration with 1 risk factors for worse outcomes, balanced solution was not superior to saline solution with respect to deaths at day 90. Reference Fernando G Zampieri, Fl via R Machado, Rodrigo S Biondi et al. Effect of Intravenous Fluid Treatment With a Balanced Solution vs 0.9% Saline Solution on Mortality in Critically Ill Patients: The BaSICS Randomized Clinical Trial. JAMA. 2021 Aug 10;326(9):1-12. Open reference URL https://web.pathway.md/studies/rec39fjNmuU1GSrw9 2/2