What effects does sodium restriction have on the antiproteinuric efficacy of angiotensin converting enzyme inhibitors?
Studies have demonstrated that dietary sodium restriction combined with angiotensin converting enzyme inhibition (ACEI) is more effective than ACEI alone in reducing proteinuria and blood pressure. This finding was supported by a randomized controlled trial which found that moderate sodium restriction added to ACEI was more effective in reducing proteinuria than dual blockade (ACEI and angiotensin II receptor blockers). Additionally, a study conducted by Vogt et al. found that dietary sodium and hydrochlorothiazide had a positive effect on the antiproteinuric efficacy of losartan, an ACEI.