6/28/23, 12:13 AM COACT Pathway Feedback Search Clinical Topics Home Studies COACT COACT Disease Cardiac arrest Trial question What is the role of immediate coronary angiography and PCI in patients who have been successfully resuscitated after out-of-hospital cardiac arrest in the absence of STEMI? Study design Multi-center Open label RCT Population Characteristics of study participants 23.0% female N = 552 77.0% male 552 patients (127 female, 425 male) Inclusion criteria: out-of-hospital cardiac arrest patients without signs of STEMI Key exclusion criteria: signs of STEMI on ECG, shock, noncoronary cause of arrest, severe renal dysfunction (GFR< 30 ml/min), pregnancy Interventions N=273 immediate coronary angiography (initiated within 2 hours after randomization in addition to PCI, if indicated) N=265 delayed coronary angiography (performed after neurologic recovery in addition to PCI, if indicated) Primary outcome Rate of survival at 90-days 67.2 67.2 % 64 5 https://web.pathway.md/studies/rece8m8EaSNnDQs4Q 1/2 6/28/23, 12:13 AM 67.2 % COACT Pathway 64.5 50.4 % 33.6 % 16.8 % No significant difference 0.0 % Immediate coronary angiography Delayed coronary angiography No significant difference in the rate of survival at 90-days (64.5% vs. 67.2%; OR 0.89, 95% CI 0.62 to 1.27) Safety outcomes No significant difference in remaining secondary end points. Conclusion In out-of-hospital cardiac arrest patients without signs of STEMI, immediate coronary angiography was not superior to delayed coronary angiography with respect to the rate of survival at 90-days. Reference Lemkes JS, Janssens GN, van der Hoeven NW et al. Coronary Angiography after Cardiac Arrest without ST-Segment Elevation. N Engl J Med. 2019 Apr 11;380(15):1397-1407. Open reference URL https://web.pathway.md/studies/rece8m8EaSNnDQs4Q 2/2