6/29/23, 1:12 AM RESTART Pathway Feedback Search Clinical Topics Home Studies RESTART RESTART Disease Intracerebral hemorrhage Trial question What is the effect of antiplatelet therapy on recurrent intracerebral hemorrhage? Study design Multi-center Single blinded RCT Population Characteristics of study participants 33.0% female N = 537 67.0% male 537 patients (177 female, 360 male) Inclusion criteria: patients on antithrombotic therapy who survived 24h post ICH after discontinuation of antithrombotic therapy Key exclusion criteria: pregnant/breastfeeding or of childbearing age and not taking contraception; traumatic ICH, hemorrhagic transformation of an ischemic CVA, or intracranial hemorrhage without intracerebral extension, taking antithrombotic therapy after ICH Interventions N=268 restarting antiplatelets (aspirin, dipyridamole, or clopidogrel) N=268 avoiding antiplatelets (no antiplatelet therapy) Primary outcome https://web.pathway.md/studies/recbyUNbuFBtYgCER 1/2 6/29/23, 1:12 AM RESTART Pathway Rate of recurrence of ICH at a median of 2 years 9.0 % 9 6.8 % 4.5 % 4 2.3 % No significant difference 0.0 % Restarting antiplatelets Avoiding antiplatelets No significant difference in the rate of recurrence of ICH at a median of 2 years (4% vs. 9%; HR 0.51, 95% CI 0.25 to 1.03) Secondary outcomes No significant difference in major hemorrhagic events (7% vs. 9%; HR 0.71, 95% CI 0.39 to 1.3) No significant difference in major occlusive vascular events (15% vs. 14%; HR 1.02, 95% CI 0.65 to 1.6) Safety outcomes No significant difference in few serious adverse events (n=11) unrelated to stroke. Conclusion In patients on antithrombotic therapy who survived 24h post ICH after discontinuation of antithrombotic therapy, restarting antiplatelets were not superior to avoiding antiplatelets with respect to the rate of recurrence of ICH at a median of 2 years. Reference RESTART Collaboration. Effects of antiplatelet therapy after stroke due to intracerebral haemorrhage (RESTART): a randomised, open-label trial. Lancet. 2019 Jun 29;393(10191):2613- 2623. Open reference URL https://web.pathway.md/studies/recbyUNbuFBtYgCER 2/2