What is PCCs?
PCCs are plasma-derived products that contain 3 (factors II, IX, and X) or 4 (addition of factor VII) clotting factors in addition to variable amounts of heparin and the natural coagulation inhibitors protein C and protein S. Animal studies have demonstrated that PCCs have variable ability to normalize anticoagulation parameters and prevent or 1160 Evidence-Based Medicine [ 15 4 # 5 CHEST NOVEMBER 2018 ] TABLE 6 ] A Simplified Schema to Assist Physician Choice of Anticoagulant (VKA or Individual NOAC) According to Patient Characteristics.