What is the effect of intensive BP control on mortality in patients with CKD without diabetes?
A meta-analysis of 5 RCTs examining the effects of intensive versus less-intensive BP control on mortality in patients with CKD without diabetes found that intensive BP control resulted in 18 fewer deaths per 1000 participants compared to the standard BP control arm (95% CI: 26 fewer 8 fewer deaths per 1000 participants). A recent individual patient-level meta-analysis of 18 trials comprising 15,294 patients with CKD found that intensive BP lowering resulted in a significantly lower risk of mortality compared to less-intensive BP lowering; this benefit was consistent across multiple subgroups.