6/29/23, 1:09 AM REDECAP Pathway Feedback Search Clinical Topics Home Studies REDECAP REDECAP Disease Weaning from mechanical ventil Trial question What is the role of high-flow oxygen and suctioning for tracheostomy decannulation in critically ill adults? Study design Multi-center Open label RCT Population Characteristics of study participants 32.0% female N = 330 68.0% male 330 patients (105 female, 225 male) Inclusion criteria: critically ill adults in the ICU who had a tracheostomy tube after being weaned from mechanical ventilation Key exclusion criteria: contraindication for decannulation at randomization, an age < 18 years, expected death before hospital discharge Interventions N=169 intervention (assessment of suctioning frequency plus receipt of continuous high-flow oxygen therapy) N=161 control (24-hour capping trial plus receipt of intermittent high-flow oxygen therapy) https://web.pathway.md/studies/recin0I7waNC91Gde 1/2 6/29/23, 1:09 AM REDECAP Pathway Primary outcome Time to decannulation 13.0 days 13 9.8 days 6.5 days 6 3.3 days No significant difference 0.0 days Intervention Control No significant difference in time to decannulation (6 days vs. 13 days; AD -7 days, 95% CI -9 to 5) Secondary outcomes Significant decrease in decannulation failure (2.4% vs. 5.6%; ARD -3.2, 95% CI -8.1 to -1.2) No significant difference in weaning failure (6.5% vs. 16.8%; ARD -10.3, 95% CI -17.4 to 3.4) No significant difference in duration of hospital stay (48 days vs. 62 days; AD -14 days, 95% CI -33 to 9) Conclusion In critically ill adults in the ICU who had a tracheostomy tube after being weaned from mechanical ventilation, intervention was superior to control with respect to time to decannulation. Reference Gonzalo Hern ndez Mart nez, Maria-Luisa Rodriguez, Maria-Concepci n Vaquero et al. High-Flow Oxygen with Capping or Suctioning for Tracheostomy Decannulation. N Engl J Med. 2020 Sep 10;383(11):1009-1017. Open reference URL https://web.pathway.md/studies/recin0I7waNC91Gde 2/2