6/27/23, 11:45 PM BOX Pathway Feedback Search Clinical Topics Home Studies BOX BOX Disease Cardiac arrest Trial question Is high BP target superior to low BP target in comatose survivors of cardiac arrest? Study design Multi-center Double blinded RCT Population Characteristics of study participants 19.0% female N = 789 81.0% male 789 patients (153 female, 636 male) Inclusion criteria: comatose adults who had been resuscitated after an out-of-hospital cardiac arrest of presumed cardiac cause Key exclusion criteria: known bleeding diathesis; unwitnessed asystole; suspected acute intracranial bleeding; stroke Interventions N=393 high BP target (targeting a mean arterial BP of 77 mmHg) N=396 low BP target (targeting a mean arterial BP of 63 mmHg) Primary outcome Death from any cause or hospital discharge with a Cerebral Performance Category of 3 or 4 at day 90 34.0 % 34 32 25 5 % https://web.pathway.md/studies/recmzOQN2EwZzQcra 1/2 6/27/23, 11:45 PM 25.5 % BOX Pathway 17.0 % 8.5 % No significant difference 0.0 % High blood pressure target Low blood pressure target No significant difference in death from any cause or hospital discharge with a Cerebral Performance Category of 3 or 4 at day 90 (34% vs. 32%; HR 1.08, 95% CI 0.84 to 1.37) Secondary outcomes No significant difference in death from any cause at day 90 (31% vs. 29%; HR 1.13, 95% CI 0.88 to 1.46) No significant difference in AKI with RRT (10% vs. 10%; HR 1.03, 95% CI 0.66 to 1.59) Safety outcomes No significant difference in serious adverse events. Conclusion In comatose adults who had been resuscitated after an out-of-hospital cardiac arrest of presumed cardiac cause, high BP target was not superior to low BP target with respect to death from any cause or hospital discharge with a Cerebral Performance Category of 3 or 4 at day 90. Reference Jesper Kjaergaard, Jacob E M ller, Henrik Schmidt et al. Blood-Pressure Targets in Comatose Survivors of Cardiac Arrest. N Engl J Med. 2022 Oct 20;387(16):1456-1466. Open reference URL https://web.pathway.md/studies/recmzOQN2EwZzQcra 2/2