How are the reversal agents for NOACs administered?
Idaracizumab is administered as 2 doses of 2.5 g IV over 5-10 minutes, 15 minutes apart. Andexanet alfa is administered as a 400-800 mg IV bolus (30 mg/min) followed by infusion of 4-8 mg/min. Ciraparantag is administered as a 100-300 mg IV bolus. 