What are the PK/PD parameters for antibiotics used in the treatment of IE?
The PK/PD parameters for antibiotics used in the treatment of IE include the ratio of the maximum serum concentration to the MIC, the ratio of the area under the 24-hour plasma concentration-time curve to the MIC (AUC24 /MIC), the duration of time that the serum concentration exceeds the MIC, and the duration of the postantibiotic effect. These parameters help predict antibiotic efficacy and optimize dose regimens for the treatment of IE.