6/28/23, 11:22 PM NORSTENT Pathway Feedback Search Clinical Topics Home Studies NORSTENT NORSTENT Disease Coronary artery disease Trial question What is the effect of drug-eluting stents in patients with stable or unstable coronary artery disease undergoing PCI? Study design Multi-center Open label RCT Population Characteristics of study participants 25.0% female N = 9013 75.0% male 9013 patients (2256 female, 6757 male) Inclusion criteria: patients who had stable or unstable coronary artery disease who were undergoing PCI Key exclusion criteria: previous treatment with coronary stent, bifurcation lesion requiring treatment with a two-stent technique, serious medical condition other than coronary artery disease with life expectancy < 5 years, intolerable side-effects to any drug in use during PCI or contraindications to long-term dual-antiplatelet therapy or had been prescribed warfarin Interventions N=4504 drug-eluting stents (everolumus- and zotarolumus-eluting stents) N=4509 bare-metal stents (contemporary devices with thin struts) https://web.pathway.md/studies/recPKoawdAkc4Jxrt 1/2 6/28/23, 11:22 PM NORSTENT Pathway Primary outcome All-cause death and nonfatal spontaneous myocardial infarction at 6 years 17.1 % 17.1 16.6 12.8 % 8.6 % 4.3 % No significant difference 0.0 % Drug-eluting stents Bare-metal stents No significant difference in all-cause death and nonfatal spontaneous myocardial infarction at 6 years (16.6% vs. 17.1%; HR 0.98, 95% CI 0.88 to 1.09) Secondary outcomes Significant decrease in any repeat revascularization at 6 years (16.5% vs. 19.8%; HR 0.76, 95% CI 0.69 to 0.85) Conclusion In patients who had stable or unstable coronary artery disease who were undergoing PCI, drug- eluting stents were not superior to bare-metal stents with respect to a all-cause death and nonfatal spontaneous myocardial infarction at 6 years. Reference Bonaa KH, Mannsverk J, Wiseth R et al. Drug-Eluting or Bare-Metal Stents for Coronary Artery Disease. N Engl J Med. 2016 Sep 29;375(13):1242-52. Open reference URL https://web.pathway.md/studies/recPKoawdAkc4Jxrt 2/2