What is the recommended treatment for native valve endocarditis caused by strains of VGS and Streptococcus gallolyticus that are relatively resistant to penicillin?
The recommended treatment for native valve endocarditis caused by strains of VGS and Streptococcus gallolyticus that are relatively resistant to penicillin is a combination of aqueous crystalline penicillin G sodium (24 million U/24 h IV either continuously or in 4-6 equally divided doses) and ampicillin or penicillin plus gentamicin. Ampicillin 2 g IV every 4 h is a reasonable alternative to penicillin if a penicillin shortage exists.