6/28/23, 11:41 PM iCBT (secondary analysis, guided iCBT vs. self-guided iCBT) Pathway Feedback Search Clinical Topics Home Studies iCBT (secondary analysis, guided iCBT vs. self-guided iCBT iCBT (secondary analysis, guided iCBT vs. self-guided iCBT Disease Disease Generalized anxiety disorder Major depressive disorder Trial question Is clinician-guided iCBT superior to self-guided iCBT among university students with anxiety and depression? Study design Multi-center Open label RCT Population 884 patients Inclusion criteria: university students with anxiety and/or depression Key exclusion criteria: positive screens for lifetime bipolar disorder or nonaffective psychosis or recent suicidal ideation with intent Interventions N=445 clinician-guided iCBT (guides sent online weekly messages to users designed to create personalized experiences and provide feedback) N=439 self-guided iCBT (no personalized messages received from clinicians) Primary outcome Joint remission of anxiety and depression at 3 months 51.8 % 51.8 38.8 % 37.8 25.9 % Significant increase 12.9 % NNT = 7 0.0 % Clinician-guided internet-delivered cognitive behavioral therapy Self-guided internet-delivered cognitive behavioral therapy https://web.pathway.md/studies/recOhJ6PE1nktRNyg 1/2 6/28/23, 11:41 PM iCBT (secondary analysis, guided iCBT vs. self-guided iCBT) Pathway Significant increase in joint remission of anxiety and depression at 3 months (51.8% vs. 37.8%; AD 14%, 95% CI 4.77 to 23.23) Secondary outcomes No significant difference in anxiety remission (62.7% vs. 50.2%; AD 12.5%, 95% CI -4.09 to 29.09) Conclusion In university students with anxiety and/or depression, clinician-guided iCBT was superior to self- guided iCBT with respect to joint remission of anxiety and depression at 3 months. Reference Corina Benjet, Nur Hani Zainal, Yesica Albor et al. A Precision Treatment Model for Internet- Delivered Cognitive Behavioral Therapy for Anxiety and Depression Among University Students: A Secondary Analysis of a Randomized Clinical Trial. JAMA Psychiatry. 2023 Jun 7;e231675. Online ahead of print. Open reference URL https://web.pathway.md/studies/recOhJ6PE1nktRNyg 2/2