What are the effects of intensive multiple risk factor reduction on coronary atherosclerosis and clinical cardiac events?
A study by Haskell et al. (1994) found that intensive multiple risk factor reduction (MRF) for coronary artery disease can reduce coronary atherosclerosis and clinical cardiac events in men and women with coronary artery disease. The study followed a cohort for four years and found that the intervention reduced the risk of death from all causes, myocardial infarction, and stroke by 40%, 50%, and 48%, respectively. The study also showed that the intervention led to significant reductions in risk factors such as cholesterol, smoking, diabetes, and hypertension. These findings suggest that intensive MRF is an effective way to reduce the risk of coronary artery disease and improve cardiovascular outcomes.