What is the recommended treatment for endocarditis caused by Enterococcus species resistant to penicillin, aminoglycosides, and vancomycin?
The recommended treatment for endocarditis caused by Enterococcus species resistant to penicillin, aminoglycosides, and vancomycin is either linezolid or daptomycin. Linezolid should be administered at a dose of 600 mg every 12 hours for a duration of 6 weeks or more. Daptomycin should be administered at a dose of 10-12 mg/kg per dose for a duration of 6 weeks or more. Patients should be treated by a care team including specialists in infectious diseases, cardiology, cardiac surgery, clinical pharmacy, and, in children, pediatrics. Cardiac valve replacement may be necessary for cure.