What data have been collected to show the impact of the Mediterranean diet on heart failure?
Data from the PREDIMED diet and the Lyon Diet Heart Study have been collected to show the impact of the Mediterranean diet on heart failure. The PREDIMED diet was a randomized primary prevention trial that found a significant reduction in the primary end point (a composite of MI, stroke, or death resulting from cardiovascular causes) in both Mediterranean diet groups compared to the control group with a low-fat diet. The Lyon Diet Heart Study was a small, randomized, secondary prevention trial of the Mediterranean diet performed in patients after first MI that showed that the Mediterranean diet group had fewer cardiac deaths, nonfatal MIs, or HF development compared to the control group after a mean follow-up of 46 months.