6/28/23, 10:00 PM ESCAPE Pathway Feedback Search Clinical Topics Home Studies ESCAPE ESCAPE Disease Heart failure Trial question What is the role of pulmonary artery catheter in patients hospitalized with severe symptomatic and recurrent HF? Study design Multi-center Open label RCT Population Characteristics of study participants 26.0% female N = 433 74.0% male 433 patients (113 female, 320 male) Inclusion criteria: patients hospitalized with severe symptomatic and recurrent HF Key exclusion criteria: creatinine level > 3.5 mg/dL, or prior use of dobutamine or dopamine > 3 g/kg/min, or any prior use of milrinone during the current hospitalization Interventions N=215 pulmonary artery catheter-guided resuscitation (therapy guided by clinical assessment and pulmonary artery catheters) N=218 resuscitation based on clinical assessment (therapy guided by clinical assessment alone) Primary outcome Time alive out of hospital at 6 months 135 135.0 days 133 https://web.pathway.md/studies/recVPyJHvjyQWuL7g 1/2 6/28/23, 10:00 PM ESCAPE Pathway y 101.3 days 67.5 days 33.8 days No significant difference 0.0 days Pulmonary artery catheter-guided resuscitation Resuscitation based on clinical assessment No significant difference in time alive out of hospital at 6 months (133 days vs. 135 days; HR 1, 95% CI 0.82 to 1.21) Secondary outcomes No significant difference in death (10% vs. 9%; OR 1.26, 95% CI 0.78 to 2.03) No significant difference in the number of days hospitalized (8.7 vs. 8.3; HR 1.04, 95% CI 0.86 to 1.27) No significant difference in in-hospital death or death at 30 days (4.7% vs. 5%; OR 0.97, 95% CI 0.38 to 2.22) Safety outcomes Significant differences in in-hospital adverse events (21.9% vs. 11.5%, p = 0.04). Conclusion In patients hospitalized with severe symptomatic and recurrent HF, pulmonary artery catheter- guided resuscitation was not superior to resuscitation based on clinical assessment with respect to time alive out of hospital at 6 months. Reference Binanay C, Califf RM, Hasselblad V et al. Evaluation study of congestive heart failure and pulmonary artery catheterization effectiveness: the ESCAPE trial. JAMA. 2005 Oct 5;294(13):1625-33. Open reference URL https://web.pathway.md/studies/recVPyJHvjyQWuL7g 2/2