What is the association between warfarin therapy duration and risk of mortality, thromboembolic complications, and bleeding?
A 2012 study by Mrie C. Kber et al. examined the association between warfarin therapy duration after bioprosthetic aortic valve replacement and risk of mortality, thromboembolic complications, and bleeding. The study found that warfarin therapy duration was associated with an increased risk of mortality, thromboembolic complications, and bleeding. This association was strongest in patients with a longer duration of warfarin therapy. The study concluded that warfarin therapy duration should be closely monitored and tailored to the individual patient's needs in order to reduce the risk of mortality, thromboembolic complications, and bleeding.