What are the major outcomes of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)?
The major outcomes of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) were published in JAMA in 2002. The results showed that high-risk hypertensive patients who were randomized to take angiotensin-converting enzyme inhibitor or calcium channel blocker had lower rates of cardiovascular events compared to those who took diuretic medications. These findings have been further supported by the PROVE IT-TIMI 22 (Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis In Myocardial Infarction 22) trial, which showed that intensive lipid-lowering statin therapy reduces the risk of recurrent cardiovascular events after an acute coronary syndrome.