What are the findings of the WHI HT trials?
The multicenter WHI randomized women into groups according to use of conjugated equine estrogen (CEE) and medroxyprogesterone or CEE alone, based on hysterectomy status. The risk of stroke with CEE was limited to IS (HR, 1.55; 95% CI, 1.19 2.01) and not hemorrhagic stroke (HR, 0.64; 95% CI, 0.35 1.18). There was no difference based on stroke pathogenic subtype, severity, or mortality. Women with no prior history of CVD were at higher risk (HR, 1.73; 95% CI, 1.28 2.33) than women with a prior history (HR, 1.01; 95% CI, 0.58 1.75).