What are the relative values of different outcomes in treating heart failure?
The committee agreed that all-cause mortality, quality of life and unplanned hospitalisation were the most critical outcomes for decision making. The committee agreed that the impact of iron on improvement in exercise tolerance, change in haemoglobin in anaemic patients, withdrawal due to adverse events/tolerability and adverse events (including hypertension, anaphylaxis/hypersensitivity, stroke and gastrointestinal issues) were also important outcomes. The committee discussed the outcome change in haemoglobin and agreed that it was only relevant to capture this information in people who had low baseline haemoglobin levels (people with anaemia) as increasing haemoglobin levels in these people was likely to have a beneficial clinical effect.