What statin regimens are suggested for people with eGFR o60 ml/min/1.73 m2 and pre-existing coronary artery disease?
The Work Group suggests that prescription of statins in people with eGFR o60 ml/ or RRT should be based on regimens and doses that have been shown to be beneficial in randomized trials done specifically in this population (Table 4). Patients with progressive renal dysfunction who are tolerating an alternative regimen do not necessarily need to be switched to a regimen described in Table 4, although dose reduction may be prudent in patients with severe kidney dysfunction who are receiving very aggressive regimens. Given less concern about drug toxicity in the setting of better kidney function, people with eGFR o60 ml/min/1.73 m2 and pre-existing coronary artery disease may be treated with any statin regimen that is approved for use in the general population.