What is the impact of major bleeding on 30-day mortality and clinical outcomes in patients with acute coronary syndromes?
A study from the ACUITY Trial found that major bleeding had a significant impact on 30-day mortality and clinical outcomes in patients with acute coronary syndromes. These findings were reported by Manoukian et al in 2007, which showed that major bleeding was associated with a greater than two-fold increase in the odds of 30-day mortality among patients with acute coronary syndromes. Furthermore, major bleeding was also associated with increased risk of recurrent myocardial infarction, stroke, and stent thrombosis. These findings suggest that clinicians should be aware of the potential risks associated with major bleeding in patients with acute coronary syndromes, and should take appropriate measures to reduce the risk of major bleeding when treating these patients.