What are the benefits of therapeutic anticoagulation in patients with NVE?
The benefit of therapeutic anticoagulation has never been demonstrated convincingly in patients with NVE. In part related to findings that demonstrated a salutary effect of intravenous aspirin therapy in established experimental S aureus a randomized trial compared oral aspirin 325 mg/d with placebo in 115 IE patients.288 No significant benefit was observed in aspirin-treated patients in terms of vegetation resolution and embolic events. Moreover, there was a trend toward more bleeding episodes in the aspirin-treated patients.