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Author Relationships With Industry and Other Entities (Relevant) 2011 ACCF/AHA Guideline for Coronary Artery Bypass Graft Surgery Committee Member Employer/Title Consultant Speaker s Bureau Ownership/ Partnership/ Principal Personal Research Institutional, Organizational, or Other Financial Benefit Expert Witness Voting Recusals by Section Numbers* L. David Hillis (Chair) University of Texas Health Science Center at San Antonio Professor and Chair of the Department of Medicine None None None None None None None Peter K. Smith (Vice Chair) Duke University Medical Center: Private Diagnostic Clinic Professor of Surgery; Chief of Thoracic Surgery Eli Lilly Baxter BioSurgery None None None None None 2.2.3 Jeffrey L. Anderson Intermountain Medical Center Associate Chief of Cardiology BMS/sanofi-aventis None None AstraZeneca Gilead Pharma Toshiba None None 2.1.6 John A. Bittl Ocala Heart Institute Munroe Regional Medical Center Interventional Cardiologist None None None None None None None Charles R. Bridges University of Pennsylvania Medical Center Chief of Cardiothoracic Surgery Baxter BioSurgery Zymogenetics Bayer Pharmaceuticals None None None Plaintiff, alleged mitral valve dysfunction, 2009 Defendant, retinal artery occlusion (stroke) after Defendant, timely insertion of IABP after Defendant, timely transport after acute aortic dissection, 2009 Plaintiff, unexpected intra-abdominal hemorrhage and death after AVR, 2009 John G. Byrne Vanderbilt University Medical Center: Division of Cardiac Surgery Chairman of Cardiac Surgery None None None None None None None Joaquin E. Cigarroa Oregon Health and Science University Associate Professor of Medicine None None None None None None None Verdi J. DiSesa John Hopkins Hospital, Division of Cardiac Surgery Clinical Associate None None None None None None None Loren F. Hiratzka Cardiac, Vascular and Thoracic Surgeons, Inc. Medical Director of Cardiac Surgery None None None None None None None Adolph M. Hutter, Jr. Massachusetts General Hospital Professor of Medicine None None None None None None None Michael E. Jessen UT Southwestern Medical Center Professor of Cardiothoracic Surgery Quest Medical None None None None None 2.1.8 Ellen C. Keeley University of Virginia Associate Professor of Internal Medicine None None None None None None None Stephen J. Lahey University of Connecticut Professor and Chief of Cardiothoracic Surgery None None None None None Defendant, mitral valve None (Continued) Hillis et al 2011 ACCF/AHA CABG Guideline e731 Appendix 1. Continued Committee Member Employer/Title Consultant Speaker s Bureau Ownership/ Partnership/ Principal Personal Research Institutional, Organizational, or Other Financial Benefit Expert Witness Voting Recusals by Section Numbers* Richard A. Lange University of Texas Health Science Center at San Antonio Professor of Medicine None None None None None None None Martin J. London University of California San Francisco, Veterans Affairs Medical Center Professor of Clinical Anesthesia None None None None None None None Michael J. Mack The Heart Hospital Baylor Plano Cardiovascular Surgery, Medical Director Cordis Marquett Medtronic Edwards Lifesciences None None None None None 2.1.3 Manesh R. Patel Duke University Medical Center Associate Professor of Medicine None None None None None None None John D. Puskas Emory University/Emory Healthcare Chief of Cardiac Surgery Marquett Medtronic None None Marquett Medtronic None None 2.1.3 Joseph F. Sabik Cleveland Clinic Foundation Professor of Surgery Edwards Lifesciences Medtronic None None None None None 2.2.2 Ola Selnes John Hopkins Hospital, Department of Neurology Professor of Neurology None None None None None None None David M. Shahian Massachusetts General Hospital Professor of Surgery None None None None None None None Jeffrey C. Trost John Hopkins School of Medicine Assistant Professor of Medicine None None None Toshiba None None 2.1.7 Michael D. Winniford University of Mississippi Medical Center Professor of Medicine None None None None None None None This table represents the relationships of committee members with industry and other entities that were determined to be relevant to this document. These relationships were reviewed and updated in conjunction with all meetings and/or conference calls of the writing committee during the document development process. The table does not necessarily reflect relationships with industry at the time of publication. A person is deemed to have a significant interest in a business if the interest represents ownership of 5% of the voting stock or share of the business entity, or ownership of $10 000 of the fair market value of the business entity; or if funds received by the person from the business entity exceed 5% of the person s gross income for the previous year. Relationships that exist with no financial benefit are also included for the purpose of transparency. Relationships in this table are modest unless otherwise noted. According to the ACCF/AHA, a person has a relevant relationship IF: (a) The relationship or interest relates to the same or similar subject matter, intellectual property or asset, topic, or issue addressed in the document; or (b) the company/entity (with whom the relationship exists) makes a drug, drug class, or device addressed in the document, or makes a competing drug or device addressed in the document; or (c) the person or a member of the person s household, has a reasonable potential for financial, professional or other personal gain or loss as a result of the issues/content addressed in the document. *Writing committee members are required to recuse themselves from voting on sections to which their specific relationships with industry and other entities may apply. No financial benefit. Significant relationship. AVR indicates aortic valve replacement; CABG, coronary artery bypass graft surgery; and IABP, intraaortic balloon pump. Appendix 2. Reviewer Relationships With Industry and Other Entities (Relevant) 2011 ACCF/AHA Guideline for Coronary Artery Bypass Graft Surgery Peer Reviewer Representation Consultant Speaker s Bureau Ownership/ Partnership/ Principal Personal Research Institutional, Organizational, or Other Financial Benefit Expert Witness Robert Guyton Official Reviewer ACCF/ AHA Task Force on Practice Guidelines None None None Edwards Lifesciences None None Jeffrey Jacobs Official Reviewer ACCF/ AHA Task Force on Data Standards None None None None None None L. Kristin Newby Official Reviewer AHA AstraZeneca None None Eli Lilly* GlaxoSmithKline None None Eric D. Peterson Official Reviewer ACCF/ AHA Task Force on Performance Measures AstraZeneca None None BMS/sanofi-aventis Eli Lilly None None Richard J. Shemin Official Reviewer AHA Edwards Lifesciences None None None None None Hector Ventura Official Reviewer ACCF Board of Governors None Actelion Gilead None None None None Thad F. Waites Official Reviewer ACCF Board of Trustees None None None None None None T. Bruce Ferguson, Jr Organizational Reviewer STS None None None None None None Stephen E. Fremes Organizational Reviewer AATS None None None None Merck Defendant, leaking thoracic aortic Defendant, aortic Colleen G. Koch Organizational Reviewer SCA None None None None None None Harold L. Lazar Organizational Reviewer AATS None None None None None None Walter H. Merrill Organizational Reviewer STS None None None None None None Stanton K. Shernan Organizational Reviewer SCA None Philips Healthcare None None None Plaintiff, communication of echocardiography Joseph S. Alpert Content Reviewer Bayer Sanofi-aventis None None None None None Robert M. Califf Content Reviewer AstraZeneca Daiichi-Sankyo GlaxoSmithKline Medtronic Sanofi-aventis None None Eli Lilly Bayer None None Robbin G. Cohen Content Reviewer None None None None None Defendant, death after minimally invasive heart Defendant, diagnosis of aortic dissection, 2010 Plaintiff, renal failure and Aprotinin, 2010 Mark A. Creager Content Reviewer ACCF/ AHA Task Force on Practice Guidelines AstraZeneca Genzyme Merck Roche Vascutek None None Merck None Plaintiff, Fasudil Development: Asahi Pharma v Actelion, (Continued) Hillis et al 2011 ACCF/AHA CABG Guideline e733 Appendix 2. Continued Peer Reviewer Representation Consultant Speaker s Bureau Ownership/ Partnership/ Principal Personal Research Institutional, Organizational, or Other Financial Benefit Expert Witness Steven M. Ettinger Content Review ACCF/AHA Task Force on Practice Guidelines None None None Medtronic None None David P. Faxon Content Reviewer Sanofi-aventis None None None None Defendant, cath vascular access site Kirsten E. Fleischmann Content Reviewer None None None None None None Lee Fleisher Content Reviewer None None None Pfizer AstraZeneca Defendant, perioperative Anthony P. Furnary Content Reviewer ACCF Surgeons Scientific Council None None None None None Defendant, Bayer Corp. Trasylol litigation, Valentin Fuster Content Reviewer None None None None None None John W. Hirshfeld, Jr Content Reviewer GlaxoSmithKline None None None None None Judith S. Hochman Content Reviewer ACCF/ AHA Task Force on Practice Guidelines Eli Lilly GlaxoSmithKline None None None None None James L. Januzzi, Jr Content Reviewer Roche None None Roche None None Frederick G. Kushner Content Reviewer Vice Chair, 2012 STEMI Guideline Writing Committee None None None None None None Glenn Levine Content Review Chair, 2011 PCI Guideline Writing Committee None None None None None None Donald Likosky Content Reviewer None None None Maquet Medtronic None None James J. Livesay Content Reviewer Southern Thoracic Surgical Association None None None None None Defendant, acute aortic Defendant, cardiac mortality review, 2010 Defendant, heparin induced Bruce W. Lytle Content CABG Guideline Writing Committee None None None None None None Robert A. Marlow Content CABG Guideline Writing Committee None None None None None None Rick A. Nishimura Content Reviewer ACCF Board of Trustees None None None None None None Patrick O Gara Content Reviewer Chair, Guideline Writing Committee None None None None None None (Continued) Appendix 2. Continued Peer Reviewer Representation Consultant Speaker s Bureau Ownership/ Partnership/ Principal Personal Research Institutional, Organizational, or Other Financial Benefit Expert Witness E. Magnus Ohman Content Reviewer ACCF/ AHA Task Force on Practice Guidelines AstraZeneca Bristol-Myers Squibb Boehringer Ingelheim Gilead Sciences Merck Pozen Sanofi-aventis Boehringer Ingelheim Gilead Sciences None Daiichi-Sankyo Datascope Eli Lilly None None John D. Rutherford Content Reviewer None None None None None None George A. Stouffer Content Reviewer None None None None None Defendant, review of malpractice claim, 2010 Mathew Williams Content ACCF Interventional Scientific Council Edwards Lifesciences Medtronic None None None None None This table represents the relationships of reviewers with industry and other entities that were disclosed at the time of peer review and determined to be relevant. It does not necessarily reflect relationships with industry at the time of publication. A person is deemed to have a significant interest in a business if the interest represents ownership of 5% of the voting stock or share of the business entity, or ownership of $10 000 of the fair market value of the business entity; or if funds received by the person from the business entity exceed 5% of the person s gross income for the previous year. A relationship is considered to be modest if it is less than significant under the preceding definition. Relationships that exist with no financial benefit are also included for the purpose of transparency. Relationships in this table are modest unless otherwise noted. Names are listed in alphabetical order within each category of review. According to the ACCF/AHA, a person has a relevant relationship IF: (a) The relationship or interest relates to the same or similar subject matter, intellectual property or asset, topic, or issue addressed in the document; or (b) the company/entity (with whom the relationship exists) makes a drug, drug class, or device addressed in the document, or makes a competing drug or device addressed in the document; or (c) the person or a member of the person s household, has a reasonable potential for financial, professional or other personal gain or loss as a result of the issues/content addressed in the document. *No financial benefit. Significant relationship. AATS indicates American Association for Thoracic Surgery; ACCF, American College of Cardiology Foundation; AHA, American Heart Association; CABG, coronary artery bypass graft surgery; PCI, percutaneous coronary intervention; SCA, Society of Cardiovascular Anesthesiologists; STEMI, ST-elevation myocardial infarction; and STS, Society of Thoracic Surgeons. Appendix 3. Abbreviation List ACE angiotensin-converting enzyme LIMA left internal mammary artery ACS acute coronary syndrome LV left ventricular AF atrial fibrillation LVEF left ventricular ejection fraction AKI acute kidney injury MACE major adverse coronary events ARB angiotensin-receptor blockers MI myocardial infarction BMS bare-metal stent NSTEMI non-ST-elevation myocardial infarction CABG coronary artery bypass graft surgery PAC pulmonary artery catheter CAD coronary artery disease PAD peripheral artery disease CKD chronic kidney disease PCI percutaneous coronary intervention CPB cardiopulmonary bypass RCT randomized controlled trial DAPT dual antiplatelet therapy SIHD stable ischemic heart disease DES drug-eluting stent SIRS systemic inflammatory response system EF ejection fraction STEMI ST-elevation myocardial infarction GDMT guideline-directed medical therapy SVG saphenous vein graft ICU intensive care unit TEE transesophageal echocardiography IMA internal mammary artery TIA transient ischemic attack LAD left anterior descending TMR transmyocardial laser revascularization LDL low-density lipoprotein UA unstable angina Hillis et al 2011 ACCF/AHA CABG Guideline e735