What is the mechanism of action of fondaparinux sodium?
The mechanism of action of fondaparinux sodium has been identified as specific binding to purified and human plasma-derived proteins. This binding is independent of antithrombin III and appears to be mediated by other plasma proteins, including heparan sulfate proteoglycans. Fondaparinux sodium does not undergo metabolism in mammalian liver fractions and does not inhibit cytochrome P450-mediated metabolism of concomitant drugs.