6/28/23, 12:08 AM CHIPS Pathway Feedback Search Clinical Topics Home Studies CHIPS CHIPS Disease Preeclampsia Trial question What is the effect of less-tight control of hypertension during pregnancy? Study design Multi-center Open label RCT Population 987 female patients Inclusion criteria: women at 14-34 weeks gestation with nonproteinuric preexisting or gestational hypertension Key exclusion criteria: proteinuria, used an angiotensin-converting-enzyme (ACE) inhibitor at 14 weeks 0 days of gestation or later, contraindication to either trial group because of a preexisting condition, known multiple gestation or a fetus with a major anomaly or chromosomal abnormality, had plans to terminate the pregnancy, Interventions N=493 less-tight control (target diastolic BP, 100 mmHg) N=488 tight control (target diastolic BP, 85 mmHg) Primary outcome Rate of pregnancy loss or requirement for high-level neonatal care for > 48 hours during the first 28 postnatal days 31.4 % 31.4 30.7 23.5 % 15.7 % 7.8 % No significant difference 0.0 % Less-tight control Tight control https://web.pathway.md/studies/recaDwJmsp6dDfMHu 1/2 6/28/23, 12:08 AM CHIPS Pathway No significant difference in the rate of pregnancy loss or requirement for high-level neonatal care for > 48 hours during the first 28 postnatal days (31.4% vs. 30.7%; aOR 1.02, 95% CI 0.77 to 1.35) Secondary outcomes Significant increase in serious maternal complications (3.7% vs. 2%; aOR 1.74, 95% CI 0.79 to 3.84) Significant increase in severe hypertension (40.6% vs. 27.5%; aOR 1.8, 95% CI 1.34 to 2.38) Conclusion In women at 14-34 weeks gestation with nonproteinuric preexisting or gestational hypertension, less-tight control was not superior to tight control with respect to the rate of pregnancy loss or requirement for high-level neonatal care for > 48 hours during the first 28 postnatal days. Reference Magee LA, von Dadelszen P, Rey E et al. Less-tight versus tight control of hypertension in pregnancy. N Engl J Med. 2015 Jan 29;372(5):407-17. Open reference URL https://web.pathway.md/studies/recaDwJmsp6dDfMHu 2/2