What is the minimal AUC24/MIC requirement for daptomycin to achieve an 80% kill efficacy in a S aureus infection mouse model?
Liu et al109 demonstrated that the minimal AUC24/MIC requirement for daptomycin with an 80% kill efficacy in a S aureus infection mouse model was 250, which would be easily achieved by the recommended for complicated bacteremia, including right-sided IE.