What are the effects of dietary protein restriction and blood-pressure control on the progression of chronic renal disease?
Modifying dietary protein restriction and controlling blood pressure have been shown to reduce the progression of chronic renal disease. Studies such as the Modification of Diet in Renal Disease Study Group (1994) and the AASK Trial (2002) have both demonstrated that those with non-diabetic chronic renal disease who had their blood pressure controlled had a reduced risk of further disease progression. Additionally, the Systolic Hypertension in the Elderly Program Cooperative Research Group (1996) showed that diuretic-based antihypertensive treatment was effective in reducing the risk of cardiovascular disease in older diabetic patients with isolated systolic hypertension. Finally, a meta-analysis of individual patient data from the Blood Pressure Lowering Treatment Trialists Collaboration (2014) showed that blood pressure-lowering treatment based on cardiovascular risk was effective in reducing the risk of cardiovascular disease and death (Ettehad et al., 2016).