6/29/23, 1:37 AM PHOENIX Pathway Feedback Search Clinical Topics Home Studies PHOENIX PHOENIX Disease Preeclampsia Trial question Is planned early delivery superior to expectant management in women with late preterm preeclampsia? Study design Multi-center Open label RCT Population 901 female patients Inclusion criteria: women with late preterm preeclampsia from 34 to 37 weeks' gestation Key exclusion criteria: decision to deliver within the next 48 hours Interventions N=450 planned delivery (induction of labor, unless there was an additional specific indication for pre-labor C-section) N=451 expectant management (delivery at 37 weeks' gestation or sooner as clinical needs dictated) Primary outcome Composite outcome of maternal death and systolic blood pressure 160 mmHg 75.0 % 75 65 56.3 % 37.5 % Significant decrease 18.8 % NNT = 10 0 0 % https://web.pathway.md/studies/recSDzyqVyxGEXPJq 1/2 6/29/23, 1:37 AM 0.0 % PHOENIX Pathway Planned delivery Expectant management Significant decrease in composite outcome of maternal death and systolic BP 160 mmHg (65% vs. 75%; RR 0.86, 95% CI 0.79 to 0.94) Secondary outcomes Significant increase in composite outcome of neonatal deaths and perinatal deaths or neonatal unit admissions at 7 days (42% vs. 34%; RR 1.26, 95% CI 1.08 to 1.47) Borderline significant decrease in the percentage of patients who progressed to severe pre- eclampsia (64% vs. 74%; RR 0.86, 95% CI 0.79 to 0.94) Borderline significant decrease in maternal morbidity (15% vs. 20%; RR 0.76, 95% CI 0.59 to 0.98) Safety outcomes No significant difference in serious adverse events. Conclusion In women with late preterm preeclampsia from 34 to 37 weeks' gestation, planned delivery was superior to expectant management with respect to the composite outcome of maternal death and systolic BP 160 mmHg. Reference Lucy C Chappell, Peter Brocklehurst, Marcus E Green et al. Planned early delivery or expectant management for late preterm pre-eclampsia (PHOENIX): a randomised controlled trial. Lancet. 2019 Sep 28;394(10204):1181-1190. Open reference URL https://web.pathway.md/studies/recSDzyqVyxGEXPJq 2/2