6/28/23, 12:24 AM CURASMUR Pathway Feedback Search Clinical Topics Home Studies CURASMUR CURASMUR Trial question Is rocuronium noninferior to succinylcholine in patients undergoing endotracheal intubation in an out-of-hospital rapid sequence intubation? Study design Multi-center Single blinded RCT Population Characteristics of study participants 39.8% female N = 1248 60.2% male 1248 patients (490 female, 736 male) Inclusion criteria: adult patients needing out-of-hospital tracheal intubation Key exclusion criteria: younger than 18 years; pregnant women; contraindication to rocuronium, succinylcholine, or sugammadex; under guardianship; no health insurance Interventions N=624 rocuronium (intravenous bolus injection of 1.2 mg/kg of body weight) N=624 succinylcholine (intravenous bolus injection of 1 mg/kg of body weight) Primary outcome Successful first-attempt intubation 79.4 % 79.4 74.6 59.6 % 39.7 % Difference exceeding nonferiority margin 19.9 % 0.0 % Rocuronium Succinylcholine https://web.pathway.md/studies/recBFLDhc4a4AOhlK 1/2 6/28/23, 12:24 AM CURASMUR Pathway Difference exceeding nonferiority margin in successful first-attempt intubation (74.6% vs. 79.4%; ARD -4.8, 97.5% CI -9 to Infinity) Secondary outcomes No significant difference in Intubation Difficulty Scale score (4.2 vs. 4.1; AD 0.1, 95% CI -0.2 to 0.4) Significant increase in intubation failure under direct laryngoscopy (1.8% vs. 0.7%; AD 1.1%, 95% CI 0.3 to 2.3) No significant difference in death during prehospital care (1% vs. 0.5%; AD 0.5%, 95% CI -0.4 to 1.3) Safety outcomes No significant differences in hypoxemia, cardiac arrest, pulmonary aspiration. Significant difference in 1 severe complication (18.9% vs. 24.4%). Conclusion In adult patients needing out-of-hospital tracheal intubation, rocuronium was not noninferior to succinylcholine with respect to successful first-attempt intubation. Reference Bertrand Guihard, Charlotte Chollet-X mard, Philippe Lakhnati et al. Effect of Rocuronium vs Succinylcholine on Endotracheal Intubation Success Rate Among Patients Undergoing Out-of- Hospital Rapid Sequence Intubation: A Randomized Clinical Trial. JAMA. 2019 Dec 17;322(23):2303-2312. Open reference URL https://web.pathway.md/studies/recBFLDhc4a4AOhlK 2/2