what are the Recommendations for Drugs of Unproven Value or Drugs That May
Worsen HF
Referenced studies that support the recommendations are summa-
rized in the Online Data Supplements.?
In patients with type 2 diabetes and high cardiovascular risk, the dipeptidyl pepti- dase-4 (DPP-4) inhibitors saxagliptin and alogliptin increase the risk of HF hospitaliza- tion and should be avoided in patients with HF.