What strategies have been developed to prevent or minimize SIRS in patients undergoing CPB?
Strategies designed to prevent or to minimize the occurrence of SIRS in patients undergoing CPB have been developed, such as the routine processing of shed blood with a cell saver before its reinfusion. However, a study failed to show an improvement in CPB-associated neurocognitive dysfunction with such a strategy. Additionally, a large RCT comparing on-pump and off-pump CABG showed no difference in the occurrence of postoperative renal failure requiring dialysis, or a decreased incidence of postoperative adverse neurological events (stroke, coma, or neurocognitive deficit) in those undergoing off-pump CABG. 