What benefits were seen in the combined analysis of the original CEA trials?
A combined analysis of these trials found the greatest benefit for CEA was in severe (70% 99%) ICA stenosis with recent symptoms. Post hoc analysis of these original trials found a greater benefit of CEA when the surgery was done in patients who were enrolled within 2 weeks of their last ischemic event. These trials were initiated >30 years ago, and current optimal medical therapy was not used in these trials.