What subpopulations of women might benefit from aspirin in reducing stroke risk?
Subgroup analyses have indicated that women with a history of hypertension may benefit from aspirin in reducing stroke risk. Additionally, a WHS post hoc subgroup analysis found that aspirin use was not associated with an increased risk of MI in those with migraine with aura, though this may have been attributable to chance. The AHA also recommends the use of aspirin for high-risk women 65 years of age or older if the benefits for ischemic stroke and MI prevention outweigh risks such as gastrointestinal bleeding and hemorrhagic stroke. Lastly, a trial evaluating the benefit of aspirin in a general population cohort with a low ankle-brachial index found no benefit of aspirin in reducing the rate of fatal or nonfatal coronary events, stroke, or revascularization procedures.