6/28/23, 11:16 PM MOSAIC Pathway Feedback Search Clinical Topics Home Studies MOSAIC MOSAIC Disease Peripheral artery disease of low Trial question Is a motivating, home-based, walking exercise behavior change intervention superior to usual care for walking in adults with PAD? Study design Multi-center Open label RCT Population Characteristics of study participants 30.0% female N = 190 70.0% male 190 patients (57 female, 133 male) Inclusion criteria: adults with PAD and intermittent claudication Key exclusion criteria: unstable intermittent claudication; walking > 90 minutes/week; contraindications to walking exercise; completion of prescribed supervised exercise sessions in the previous 6 months Interventions N=95 motivating structured walking activity treatment (home-based, walking exercise behavior change intervention delivered by physical therapists trained to use a motivational approach) N=95 usual care (initial assessment, drug therapy, and simple advice to walk provided by a vascular specialist) https://web.pathway.md/studies/recCa4SgjWCCT2vda 1/2 6/28/23, 11:16 PM MOSAIC Pathway Primary outcome Mean improvement in 6-minute walking distance at 3-month follow-up 27.7 m 27.7 20.8 m 13.8 m 6.9 m Significant increase 2.3 0.0 m Motivating structured walking activity treatment Usual care Significant increase in mean improvement in 6MWD at 3-month follow-up (27.7 m vs. 2.3 m; MD 16.7, 95% CI 4.2 to 29.2) Secondary outcomes Significant increase in mean improvement in Walking Estimated Limitation Calculated by History score at 6 months (MD 7.4, 95% CI 2.5 to 12.3) Significant increase in mean improvement in attitude component of the theory of planned behavior questionnaire score at 6 months (0.7 vs. -0.7; MD 1.4, 95% CI 0.3 to 2.5) Conclusion In adults with PAD and intermittent claudication, motivating structured walking activity treatment was superior to usual care with respect to mean improvement in 6MWD at 3-month follow-up. Reference Lindsay M Bearne, Brittannia Volkmer, Janet Peacock et al. Effect of a Home-Based, Walking Exercise Behavior Change Intervention vs Usual Care on Walking in Adults With Peripheral Artery Disease: The MOSAIC Randomized Clinical Trial. JAMA. 2022 Apr 12;327(14):1344-1355. Open reference URL https://web.pathway.md/studies/recCa4SgjWCCT2vda 2/2