6/28/23, 11:06 PM HOT-ICU Pathway Feedback Search Clinical Topics Home Studies HOT ICU HOT ICU Disease Acute respiratory distress syndr Trial question Is lower oxygenation target superior to higher oxygenation target in patients with acute hypoxemic respiratory failure? Study design Multi-center Open label RCT Population Characteristics of study participants 36.0% female N = 2910 64.0% male 2910 patients (1039 female, 1871 male) Inclusion criteria: adult patients with acute hypoxemic respiratory failure in the ICU Key exclusion criteria: not randomized within 12 hours of ICU admission; receives chronic mechanical ventilation; use of home oxygenation; previous treatment with bleomycin; pregnancy Interventions N=1453 lower oxygenation target (partial pressure of oxygen in arterial blood 60 mmHg) N=1457 higher oxygenation target (partial pressure of oxygen in arterial blood 90 mmHg) Primary outcome Death at day 90 42.9 % 42.9 42.4 32 2 % https://web.pathway.md/studies/rec2C5I1SQxLcdbEA 1/2 6/28/23, 11:06 PM 32.2 % HOT-ICU Pathway 21.4 % 10.7 % No significant difference 0.0 % Lower oxygenation target Higher oxygenation target No significant difference in death at day 90 (42.9% vs. 42.4%; RR 1.02, 95% CI 0.94 to 1.11) Secondary outcomes No significant difference in the percentage of days alive within life support (87.8% vs. 84.4%; AD 3.4%, 95% CI -0.65 to 7.45) No significant difference in the percentage of days alive after hospital discharge (55.6% vs. 50%; AD 5.6%, 95% CI -19.12 to 30.32) Safety outcomes No significant difference in serious adverse events. Conclusion In adult patients with acute hypoxemic respiratory failure in the ICU, lower oxygenation target was not superior to higher oxygenation target with respect to death at day 90. Reference Olav L Schj rring, Thomas L Klitgaard, Anders Perner et al. Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure. N Engl J Med. 2021 Apr 8;384(14):1301-1311. Open reference URL https://web.pathway.md/studies/rec2C5I1SQxLcdbEA 2/2