Single Molecule Imaging of Genome Duplication and Maintenance Laboratory
Job title: Postdoctoral Fellow – H Yardimci lab
Reporting to: Hasan Yardimci, Senior Group Leader
Contact term: This is a full-time, fixed term 4 years position on Crick terms and conditions of employment.
The Research Group
Our laboratory investigates processes involved in eukaryotic DNA replication and genome maintenance using conventional biochemistry and single-molecule visualization tools. To study eukaryotic replication, we use a number of model systems including Xenopus egg extracts and a reconstituted system with purified human proteins. The group currently consists of around 6 researchers including PhD students, postdoctoral fellows and laboratory research scientists. For more information, please see the laboratory website.
We aim to unravel the intricate mechanisms of eukaryotic DNA replication machinery as it maneuvres through the chromatin landscape, shedding light on the processes that ensure accurate genome duplication. Employing the precision of single-molecule fluorescence microscopy, we can observe replisome dynamics unfold in real time. Previous work in our lab has shed light on the interplay between DNA replication and essential chromatin processes, including parental histone recycling (Gruszka et al, 2019. Sci Adv) and the establishment of sister chromatid cohesion (Cameron et al, 2024. Science). Building on these foundations, our current project seeks to elucidate the molecular intricacies of these interactions, potentially revolutionizing our understanding of genomic fidelity.
The Postdoctoral Fellow will lead their own projects, contribute to other projects in the lab and may guide PhD students in their research. They will have the opportunity to present their work at international conferences and partake in interdisciplinary collaborations that will expand both knowledge and professional networks. Therefore, the ability to work in a team is essential.
Informal enquiries are welcome, and should be directed to Hasan Yardimci (email@example.com).
Key experience and competencies
The post holder should embody and demonstrate our core Crick values: bold, imaginative, open, dynamic and collegial, in addition to the following:
- PhD (including but not limited biochemistry and biophysics) or in the final stages of PhD submission
- Strong interest in genome maintenance
- Track record of writing papers as evidenced by publications or submitted manuscripts in referred journals
- Evidence of data presentation at scientific meetings
- Excellent organisational and communication skills
- Ability to work independently and also capable of interacting within a group
- Experience in protein biochemistry
- Experience in working with nucleic acid processing enzymes
- Experience in single-molecule methods including TIRF microscopy
At the Crick, we conduct research at the forefront of biomedical research. We combine rigour with an open and collaborative culture, and are outward-looking, reflecting our status as a partnership of six organisations aiming to pool knowledge, ideas and resources.
We have a wide research portfolio with no divisions or departments, bringing biomedical researchers together with clinicians, physical scientists and applied scientists from our pharmaceutical partners.
We aim to attract the most talented researchers and support them to tackle innovative research questions. Our science technology platforms provide our researchers with access to state-of-the-art technology and expertise.
We provide an excellent learning environment with dedicated education programmes in public engagement with science, education and personal development, and a postdoc training programme that prepares scientists for leadership roles in science.
From £43,210 with benefits, subject to skills and experience
Hours per week
36 (full time)