AFAIK PyTorch itself tries to strike a balance for performance rather than optimizing for any CPU in particular. I think it depends on what computation you expect to do on CPU and the relative performance difference due to Intel vs. AMD differences (e.g., MKLDNN has AVX-512 support and AVX-512 support was recently landed in upstream: Add AVX512 support in ATen & remove AVX support by imaginary-person · Pull Request #56992 · pytorch/pytorch (github.com) 4, is maximum SIMD width or higher core count more important for your workload?).