If your input shape is 2x8x16x192x192, so batchsize=2, channel=8, volume size=16192192. Channel is usually set to 1 or 3. I think channel is not True. I think you image data maybe MRI. MRI data may have 4 modality, so the channel maybe 4 or others. You can set 2x1x16x192x192 to train 3DUNet or other 3D NetWork. The meaning of “8” equivalent to 4x2, 4 batch(batchsize is 2).