I’m not sure, if slices would work and I assume it depends a bit on your use case.
E.g. if you are dealing with a classification use case, I would assume that smaller patches of the original image could not contain the valid class at all.
So passing a patch with just “sky”, while the prediction could be “dog” could confuse the model.
However, probably the best way is just to try it out and see, if the model is able to catch enough information from the smaller patches.