Hi,
I emerged with the problem.
RuntimeError: one of the variables needed for gradient computation has been modified by an inplace operation: [torch.cuda.FloatTensor [4]] is at version 1; expected version 0 instead. Hint: enable anomaly detection to find the operation that failed to compute its gradient, with torch.autograd.set_detect_anomaly(True).
this is my code

from model import Generator,Discriminator
from config import *
from loss import *

import torch
import torch.nn as nn
import torch.optim as optim
from torchvision.utils import save_image


import re
import os
import unicodedata
import numpy as np
from PIL import Image

class Train():

    def __init__(self):

        device = torch.device("cuda")

        self.G = Generator(g1_pram,g2_pram,g3_pram,g4_pram).to(device)
        self.D = Discriminator(d1_pram,d2_pram,d3_pram,d4_pram).to(device)

        self.G_optimizer = optim.SGD(self.G.parameters(),lr = G_lr)
        self.D_optimizer = optim.SGD(self.D.parameters(),lr = D_lr)

        self.down1 = nn.Upsample(scale_factor=(0.5,0.5),mode="nearest")
        self.down2 = nn.Upsample(scale_factor=(0.5,0.5),mode="nearest")
        self.down3 = nn.Upsample(scale_factor=(0.5,0.5),mode="nearest")

        self.scheduler_D = torch.optim.lr_scheduler.StepLR(self.D_optimizer, step_size = step_size, gamma = gamma)
        self.scheduler_G = torch.optim.lr_scheduler.StepLR(self.G_optimizer, step_size = step_size, gamma = gamma)
        self.BCEloss = nn.BCELoss()

        self.gen_img = None

    def D_loss(self,discriminate,label):
        
        D_loss_1 = self.BCEloss(discriminate[0].view(-1),label)
        D_loss_2 = self.BCEloss(discriminate[1].view(-1),label)
        D_loss_3 = self.BCEloss(discriminate[2].view(-1),label)
        D_loss_4 = self.BCEloss(discriminate[3].view(-1),label)

        return D_loss_1 + D_loss_2 + D_loss_3 + D_loss_4

    def GDL_loss(self, y, gen_img):
        d4_in = y
        d3_in = self.down3(d4_in)
        d2_in = self.down2(d3_in)
        d1_in = self.down1(d2_in)
        y = [d1_in,d2_in,d3_in,d4_in]

        G_loss_1 = loss_gdl(gen_img[0],y[0],1) * lambda_gdl
        G_loss_2 = loss_gdl(gen_img[1],y[1],1) * lambda_gdl
        G_loss_3 = loss_gdl(gen_img[2],y[2],1) * lambda_gdl
        G_loss_4 = loss_gdl(gen_img[3],y[3],1) * lambda_gdl

        return G_loss_1 + G_loss_2 + G_loss_3 + G_loss_4


    def scheduler(self):
        self.scheduler_D.step()
        self.scheduler_G.step()


    def train(self,x,y):
        
        real_label = 1.
        fake_label = 0.

        self.G.train()
        self.D.train()

        b_size = x.size()[0]
        label = torch.full((b_size,), real_label, device=torch.device("cuda"))

        # Train D
        
        self.D_optimizer.zero_grad()
        real = self.D(x,y)
        real_loss = self.D_loss(real,label)
        #real_loss.backward()
        
        #self.D_optimizer.zero_grad()
        fake_img = self.G(x)
        fake_img = [i.detach() for i in fake_img]
        fake = self.D(x,fake_img)
        label.fill_(fake_label)
        fake_loss = self.D_loss(fake, label)
        #fake_loss.backward()
        dloss = real_loss + fake_loss
        dloss.backward()
        self.D_optimizer.step()

        # Train G
        
        self.G_optimizer.zero_grad()
        gen_img = self.G(x)
        gen = self.D(x,y)
        label.fill_(real_label)
        
        adv_loss = self.D_loss(gen, label)
        gdl_loss = self.GDL_loss(y, gen_img)
        
        gloss = adv_loss + gdl_loss
        gloss.backward()
        self.G_optimizer.step()

        True_loss = real_loss
        False_loss = fake_loss + adv_loss
        criterion = nn.MSELoss()
        MSE_loss = criterion(gen_img[-1],y[-1])

        self.gen_img = gen_img

        return True_loss, False_loss, MSE_loss

    def predict(self,x,y):
        
        with torch.no_grad():
            real_label = 1.
            fake_label = 0.

            self.G.train()
            self.D.train()

            b_size = x.size()[0]
            label = torch.full((b_size,), real_label, device=torch.device("cuda"))

            # Predict D
            
            real = self.D(x,y)
            real_loss = self.D_loss(real,label)
            
            fake_img = self.G(x)
            fake_img = [i.detach() for i in fake_img]
            fake = self.D(x,fake_img)
            label.fill_(fake_label)
            fake_loss = self.D_loss(fake, label)

            # Predict G
            
            gen_img = self.G(x)
            gen = self.D(x,y)
            label.fill_(real_label)
            
            adv_loss = self.D_loss(gen, label)
            gdl_loss = self.GDL_loss(y, gen_img)
            
            gloss = adv_loss + gdl_loss

            True_loss = real_loss
            False_loss = fake_loss + adv_loss
            criterion = nn.MSELoss()
            MSE_loss = criterion(gen_img[-1],y[-1])

        self.gen_img = gen_img
        return True_loss, False_loss, MSE_loss


    def img_save(self, img_path):
        print(self.gen_img[-1][0].size())
        save_image(self.gen_img[-1][0], img_path)

    def model_save(self, model_path):
        torch.save(self.D.state_dict(),model_path[0])
        torch.save(self.G.state_dict(),model_path[1])

        

if __name__ == '__main__':
    T = Train()
    device = torch.device("cuda")
    import time
    for i in range(1000):
        print(i)
        print("start", [...])
        start = time.time()
        x = torch.autograd.Variable(torch.randn(4,12,105,80)).to(device)
        y = torch.autograd.Variable(torch.randn(4,3,105,80)).to(device)

        z = T.train(x,y)
        save_img = True if i % 10 == 0 else False
        w = T.predict(x,y)
        if save_img:
            T.img_save("oppai.png")
        save_model = True if i % 10 == 0 else False
        if save_model:
            T.model_save(["D","G"])
        
        print("end batch", [...])
        print(time.time()-start, [...])


0
start [Ellipsis]
Traceback (most recent call last):
  File "train_ops.py", line 184, in <module>
    z = T.train(x,y)
  File "train_ops.py", line 94, in train
    dloss.backward()
  File "/home/hikarukondo/.local/lib/python3.6/site-packages/torch/tensor.py", line 150, in backward
    torch.autograd.backward(self, gradient, retain_graph, create_graph)
  File "/home/hikarukondo/.local/lib/python3.6/site-packages/torch/autograd/__init__.py", line 99, in backward
    allow_unreachable=True)  # allow_unreachable flag
RuntimeError: one of the variables needed for gradient computation has been modified by an inplace operation: [torch.cuda.FloatTensor [4]] is at version 1; expected version 0 instead. Hint: enable anomaly detection to find the operation that failed to compute its gradient, with torch.autograd.set_detect_anomaly(True).