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"The instruction for medical use    of SOLKOSERIL medicine  the Trade name  Solkoseril  Mezhdunarodnoye the unlicensed name  Is not present  the Dosage form  Gel of eye, 5 g  Structure  1 g of gel contains  active agent - deproteined hemoderivative from blood of milk calfs (Bos Taurus) standardized chemically and biologically 8.3 mg,  excipients - a benzalkoniya chloride, sodium carboxymethylcellulose, edetat sodium a dihydrate, sorbitol of 70%, water for injections, solution of sodium of hydroxide of 27% (for adjustment rn).  The description  From colourless till slightly yellowish color poorly opalescent fluid gel, almost flavourless  Pharmacotherapeutic group  Drugs for treatment of diseases of eyes  Drugs for treatment of diseases of eyes other  the ATX S01XA Code  the Pharmacological   Pharmacokinetics As well as properties in a case with other biologically standardized drugs, absorption, distribution and elimination of active component of the drug Solkoseril eye gel - deproteined hemoderivative cannot be studied by usual pharmacokinetic methods. Besides, deproteined hemoderivative of blood of milk calfs contains low-molecular components of serum and blood cells in the structure, it is normal of attendees in an organism.  The pharmacodynamics  Active component of the drug Solkoseril represents eye gel chemically and biologically standardized deproteined hemoderivative received from blood of milk calfs (Bos Taurus) by dialysis and ultrafiltration (nominal size 5000 Yes). Solkoseril contains a large number of the low-molecular components received from cells and blood serum of milk calfs: electrolytes, amino acids, nucleotides, nucleosides, oligopeptida and intermediate products carbohydrate and lipometabolism. Clinical performance of drug is caused by synergism of all Solkoserila components. Established that Solkoseril:  - supports and restores the processes of aerobic metabolism and oxidizing phosphorylation, filling shortage of high-energy phosphates in cells, improves utilization of oxygen and accelerates glucose transport in metabolic exhausted fabrics and cells subject to a hypoxia,  - accelerates processes of regeneration of the damaged and/or exhausted fabrics,  - warns or reduces risk of emergence of a secondary degeneration and pathological changes in reversibly the damaged cells,  - accelerates processes of synthesis of collagen and stimulates processes of proliferation and migration in cells.  Solkoseril eye gel protects fabrics from a hypoxia and/or nutrient deficiency, promotes restoration of normal functioning of fabrics with reversible damages and accelerates process of healing of damages, at the same time improving quality of healing. Solkoseril eye gel is the dosage form developed especially for treatment of defeats of a cornea and a conjunctiva as it promotes angenesis and reduces risk of formation of hems. Thanks to the gel consistence caused by presence at composition of drug of sodium salt of carboxymethylcellulose, Solkoseril has good adhesive properties and provides a uniform and long-term covering of a cornea and a conjunctiva owing to what active agent continuously gets into the struck fabric.  Indications  of Adyyuvantnaya therapy in complex treatment:  - helcomas of various origin  - damages of a cornea  - the burns of a cornea caused by alkalis or acids  - degenerative changes of a cornea and conjunctiva  - a bullous keratitis  the Route of administration and doses  to Adults and children are more senior than 8 years to dig in 3-4 times a day on 1 drop of eye gel in a conjunctival sac.  By-effects  - short-term weak burning (that is not the reason for drug withdrawal)  - allergic reactions, occasionally at reuse  of the Contraindication  - hypersensitivity to drug components  - children up to 8 years  Medicinal interactions  At simultaneous use of several ophthalmologic drugs it is necessary to dig in eye gel not earlier than in 15 minutes after use of other medicine.  Eye gel the efficiency of locally applied antinukleozidny virostatik, such as Acyclovir or Idoksuridin can reduce natural metabolites of the drug Solkoseril.  Special instructions  When burying it is not necessary to touch a tube tip fingers. It is recommended to close a tube at once after drug use.  During the Solkoseril drug treatment eye gel it is necessary to refrain from carrying contact lenses, owing to sticking of gel to a surface of contact lenses.  In case of infection of an eye Solkoseril is not recommended to apply eye gel as the only medicine.  Use of drug in pediatrics  Use of drug for treatment of children is more senior than 8 years perhaps on doctor&#039;s orders.  Pregnancy and the period of a lactation  Clinical trials of Solkoseril of eye gel at pregnancy and in the period of a lactation were not carried out. Use of drug for treatment of pregnant women and the feeding women perhaps on doctor&#039;s orders if the expected advantage exceeds risk for a fruit and the child.  The feature of influence of medicine on ability to run the vehicle or potentially dangerous mechanisms  Due to the temporary decrease in clearness of visual perception within 20 min. after use of eye gel to patients should abstain from occupations potentially dangerous types of activity (driving of the car, work with mechanisms, etc.).  The overdose  is not revealed  the Form of release and packing  On 5 g of drug place in tubas aluminum with the applicator and the screw-on cap.  On 1 tuba together with the instruction for medical use in the state and Russian languages place in a pack from cardboard.   To Store storage conditions at a temperature not above 25 &deg;C.  To store out of children&#039;s reach!  A period of storage  3 years  the use Period after opening of a tuba &ndash; 4 weeks, at a temperature not above 25 &deg;C.  Not to apply after an expiration date.  Prescription status  According to the prescription  the Producer  of Legasi Pharmasyyutikals Switzerland Ryurbergstrasse  21, 4127 GmbH Birsfelden, Switzerland  the Owner of the registration certificate  of MEDA Pharm GmbH, Austria  the Address of the organization accepting in the territory of the Republic of Kazakhstan claims from consumers on quality of products  Representation Pharmasyyutikalz HONEY Switzerland GmbH in the Republic of Kazakhstan: Almaty, Dostyk Ave. 97, office 8, ph. 264-17-94, ph./fax 264-17-71  E-mail address: info.safety@meda-cis.com"
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