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"\nHerbal And Nutritional Support For Phase I And II Liver Detoxification.\n\n\nComprehensive formula that assists gut health, liver and cellular detoxification processes.\nConjugating amino acids, milk thistle and green tea for phase II detoxification and protection against reactive toxins.\nLow reactive, non GMO pea protein for improved patient compliance.\nPart of the Metagenics Detoxification Programs.\n\n\nClinical Benefits\nReduce toxic load by supporting gut barrier function, microbiome health and lipopolysaccharide (LPS) reactions. Glutamine may help to protect gut integrity and permeability1 with zinc to reduce mucosal permeability,2 and gram negative bacterial translocation.3 Taurine and the Traditional Chinese Medicine herb, gardenia, support the liver, with in vitro work showing taurine to reduce LPS activation of liver Kupffer cells.4 Arabinogalactans from larch provide prebiotic benefits to stimulate short chain fatty acid production, and lactobacilli and bifidobacterium growth as part of a healthy gut microbiome.\nImproves cellular liver detoxification capacity: Milk thistle has been used in Western herbal medicine to assist the detoxification capacity of the liver. Silymarin inhibits beta-glucuronidase activity to assist the elimination of metabolites conjugated through phase II detoxification.7Green tea polyphenols also stimulate the activity of hepatic detoxification enzymes, thereby promoting detoxification of xenobiotic compounds.\nNeutralises reactive toxins: Antioxidants, such as selenium, zinc and green tea, help protect against potential free radical damage from reactive toxins formed during phase 1.9 Cysteine and glutamine help synthesise glutathione,10 a major endogenous antioxidant, to help protect cells against reactive hydroxyl free radicals.11 Glutathione is also a substrate for the major phase II detoxification pathway, glutathionation.12 Pea protein is a natural source of glutamine and glycine. Green tea has also demonstrated high antioxidant activity with an ability to scavenge hydroxyl and superoxide radicals.13 It is hypothesised that green tea catechins, by decreasing the oxidative stress in cells, modulate the expression of antioxidant enzyme (AE) genes.\nEliminates and conjugates toxins: The low reactive, non GMO high quality pea protein in Thermophase Detox Essentials supplies essential amino acids and nutrients to support major phase II conjugation pathways (Figure 1). Phase II detoxification pathways are dependent upon adequate substrates to carry out conjugation reactions.15 Phase II detoxification pathways transform intermediate metabolites formed from phase I detoxification to be more water-soluble and therefore more easily excreted in the bile and urine.16 Thermophase Detox Essentials with taurine,17 and the TCM herb, gardenia,18 assists in promoting the body's elimination of wastes via the liver and bile.\n\nIngredients\n\n\n\n\nEach dose (19.0 g) contains:\n\n\n\n\n\n\n\nExtracts equivalent to:\n\n\n\n\n\n\n\nSilybum marianum, seed dry (Milk thistle)\n\n\n6.0 g\n\n\n\n\nStandardised to flavanolignans calc. as silybin\n\n\n72 mg\n\n\n\n\nCamellia sinensis, leaf dry (Green tea)\n\n\n5.2 g\n\n\n\n\nGardenia jasminoides, fruit dry (Cape jasmine)\n\n\n1.5 g\n\n\n\n\nLarix arabinogalactan (Larch)\n\n\n1.0 g\n\n\n\n\nMagnesium amino acid chelate (Meta Mag- Magnesium bisglycinate)\n\n\n1.0 g\n\n\n\n\nEquivalent Magnesium\n\n\n100 mg\n\n\n\n\nGlutamine\n\n\n1.5 g\n\n\n\n\nCysteine\n\n\n50 mg\n\n\n\n\nTaurine\n\n\n350 mg\n\n\n\n\nAscorbic acid (Vitamin C)\n\n\n250 mg\n\n\n\n\nZinc amino acid chelate (Meta Zn- Zinc bisglycinate)\n\n\n75 mg\n\n\n\n\nEquivalent Zinc\n\n\n15 mg\n\n\n\n\nCalcium pantothenate (Vitamin B5)\n\n\n55 mg\n\n\n\n\nPyridoxine hydrochloride (Vitamin B6)\n\n\n50 mg\n\n\n\n\nd-alpha-Tocopheryl acid succinate\n\n\n32 mg\n\n\n\n\nEquivalent d-alpha-Tocopheryl\n\n\n25 mg\n\n\n\n\nNicotinamide (Vitamin B3)\n\n\n50 mg\n\n\n\n\nPyridoxal 5-phosphate monohydrate (Vitamin B6)\n\n\n50 mg\n\n\n\n\nd-alpha-Tocopheryl acid succinate\n\n\n32 mg\n\n\n\n\nEquivalent d-alpha-Tocopherol\n\n\n25 mg\n\n\n\n\nThiamine hydrochloride (Vitamin B1)\n\n\n25 mg\n\n\n\n\nRiboflavin sodium phosphate (Riboflavin 5-phosphate sodium)\n\n\n14 mg\n\n\n\n\nEquivalent Riboflavin (Vitamin B2)\n\n\n10 mg\n\n\n\n\nBetacarotene\n\n\n2.7 mg\n\n\n\n\nMecobalamin (Co-methylcobalamin) (Vitamin B12)\n\n\n200 micrograms\n\n\n\n\nSelenomethionine\n\n\n186 micrograms\n\n\n\n\nEquivalent Selenium\n\n\n75 micrograms\n\n\n\n\n\n\n\n\n\nExcipients: Pisum sativum seed (Pea) (63.15%), natural and nature identical flavours (4.84%), maltodextrin (MetaFibre), xanthan gum, citric acid and steviol glycosides.\nFree from dairy protein, lactose, eggs, gluten, wheat, nuts, yeast, salt and soy protein.\nFree from artificial colours and flavours. Sweetened with steviol glycosides.\n\nDirections\nAdults: Add 1 level scoop (19.0 g) to 200 mL of water twice daily.\nProduct settling occurs. Ensure lid is tightly closed and invert product twice before use"
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