_:n62ee203a8070434dbb680d08aac1576dxb0
<http://schema.org/abstract>
"<p>With the help of an inexpensive iron porphyrin catalyst, chemists in Switzerland have developed a safe way to generate diazomethane, an important reagent for cyclopropanation reactions (Science, DOI: 10.1126/science.1218781). The new user-friendly protocol provides chemists with easy access to cyclopropyl groups for pharmaceuticals and materials. As tools of the chemical trade go, diazomethane (CH2N2) demands special care. Not only is it explosive, but it’s also highly toxic. Even less explosive analogs of the compound, such as trimethylsilyldiazomethane, have proven deadly, with two chemists succumbing to the effects of that compound in separate events in 2008 (C&amp;EN, May 9, 2011, page 15). Chemists usually generate diazomethane by treating the N-nitroso compound Diazald with base and then distilling the resulting diazomethane with a specialized apparatus to lessen the chance of explosion. Now, Erick M. Carreira and Bill Morandi of the Swiss Federal Institute of Technology, Zurich, have developed a way of generating</p>"
<https://cen.acs.org/articles/90/i13/Taming-Diazomethane.html>