<https://portlandpress.com/essaysbiochem/article/61/6/663/78491/Molecular-control-of-chaperone-mediated-autophagy>
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"Soluble cytosolic substrates bearing a KFERQ motif are first recognized by HSPA8 and transported to the lysosomal membrane where they bind to monomeric Lamp2a. With the assistance of Hsp90, Lamp2a oligomerizes into a functional translocation complex. Following substrate unfolding mediated by a chaperone complex; the substrate is translocated into the lysosomal lumen with the aid of a lysosomal form of HSPA8. After the release of the substrate from the translocation complex, cytosolic HSPA8 mediates the disassembly of the Lamp2a translocation complex in order to restart the process."
<https://portlandpress.com/essaysbiochem/article-abstract/61/6/663/78491/Molecular-control-of-chaperone-mediated-autophagy?redirectedFrom=PDF>