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"firewatcher - thanks for the information!  I'm currently on 20mg AM and 20mg PM with the Propranolol.  I had briefly tried a larger amount, but the fatigue and side effects crept up on me.  The Melatonin is 3 mg.  Maybe a smaller amount would be better, wouldn't be the first time for me! My research started with involvement of the gut flora, so I do believe this plays a part, somehow.  It is entirely possible that nutrient absorption and/or modulation of the ANS/immune system by the gut flora is disrupted.  This explains the sudden onset. Unfortunately, as I'm sure you've discovered, there are a number of products out there and results are pretty sketchy.  I believe that the old fashioned, fermented foods are greatly superior to the supplements, as they have nourished and helped others for millennia.  Out of curiosity, then, are you taking miso routinely? This actually makes a TON of sense, as the H3 receptors can inhibit release of serotonin, dopamine, GABA, acetylcholine, and norepinephrine.  They are present in the central and peripheral nervous system, heart, lungs, GI tract, and endothelial cells that line blood and lymph vessels.  All areas that are commonly affected in dysautonomia. I'll have to dig deeper into any compounds that might act on these receptors. "
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