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"Thanks again Wishclean.  I ordered nettle tincture online today to replace the saw palmetto.  I am going to stop taking it for a while as I am incredibly irritable and low.  (I'm beginning to go through withdrawal symptoms from an antidepressant for anxiety so it's difficult to work out what is causing what.  But I do seem to be more irritable since adding in saw palmetto two weeks ago.) \nI do need to keep with the B12 jabs as I don't absorb it through my stomach      (I was deficient and had a whole world of awful symptoms - not being able to walk, hair falling out, losing my memory, losing sensation in my limbs and constant migraines being some of them.) \nI'll let you know how it goes with the Origins pads.  Fingers crossed.  They're quite expensive but I'll pay it if it clears me up a bit.  A friend got me onto the idea, as she was using saw palmetto on her scalp for androgenic alopecia, and when I read up on it I saw that follicles should theoretically be receptive to topical application. \nI think I need to read up on hormones a bit more.  I have difficulty understanding the oestrogen dominance theory.  I don't understand why the well-known progesterone only pill side effects are low mood and acne, if progesterone is meant to be the better of the two for skin and mood.  Similarly, why PMT symptoms happen when estrogen drops but progesterone is high.  I also don't understand why the theory says that menopausal women have oestrogen dominance, when the menopause causes lowering of oestrogen - and doctors say that the menopause symptoms like flashes and acne are due to lower oestrogen.  (NB I'm not saying it's wrong, I just don't understand it!)  It makes me a little nervous of adding a progesterone supplement - largely because I'm worried about making my anxiety and PMT worse.  I thought about trying agnus castus - but everyone I know that has had success with it has an underlying menstrual cycle problem, such as ovulation problems (which I don't have).  Maybe I should just leave the hormonal supplements alone! \n"
<https://www.acne.org/forums/topic/343456-oestrogen-testosterone-progesterone-questions-and-saw-palmetto/>