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"You have quoted cymbaln00b quoting a pharmacist that cymbaln00b says may not be communicating accurate information. This is advice at least twice removed from an unreliable source.\n \n\n\n\t \n \n\n\n\tWe have many people here successfully tapering duloxetine by counting beads or using the mini-tablets. Variation in the beads, if any, averages out in a dose.\n \n\n\n\t \n \n\n\n\n\n\t \n \n\n\n\tYes, we know this is available. The powder has to be packaged in something to extend its release. Without protection, the chemical formula of duloxetine is destroyed by stomach acid.\n \n\n\n\t \n \n\n\n\n\n\t \n \n\n\n\tThis indicates the pharmacist is aware that the capsule alone doesn't do the job. I would want to know more about the timing equivalency.\n \n\n\n\t \n \n\n\n\n\n\t \n \n\n\n\tThe beads are coated so they can travel through the stomach and dissolve in the intestines.\n \n\n\n\t \n \n\n\n\tThe question you want to ask PCCA is if they have tested equivalence in release between prescription duloxetine beads and their formulation with delayed-release capsules (they are plastic) combined with the delayed-release filler. You want to find out to what extent the person is guessing.\n \n\n\n\t \n \n\n\n\tPCCA probably won't know anything about the composition of duloxetine beads, you'd have to ask the manufacturer for that. Be aware that anyone you speak to on the phone might not know what they're talking about.\n "
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