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"I have been in touch with the PCCA since yesterday afternoon to learn about obtaining extended-release duloxetine and who in my area has compounded duloxetine. The PCCA Customer Service Representative told me the following, which may be helpful:\n \n\n\n\t \n \n\n\n\t\"Duloxetine can be made into an Acid Resistant capsule which delays the release until it reaches the intestinal area.  There may be something further they can do with the actual formulation regarding the gradual tapering of the dosage over time after that, but that would be something they would need to discuss with one of our clinical services consultants.\"\n \n\n\n\t \n \n\n\n\tThe PCCA also indicated the names of two pharmacies in my state who have ordered duloxetine powder in the last 4 months. I have left word with them to contact me for futher information - including whether they have tested equivalence in release between prescription duloxetine beads and their formulation with delayed-release capsules (they are plastic) combined with the delayed-release filler. The PCCA indicated that they do not have control over what the pharmacies actually do as they are independent. I was repeatedly told that the pharmacist should contact a PCCA clinical service consultant as that is 'what the pharmacies are paying for.'\n \n\n\n\t \n \n\n\n\tI am currently using the duloxetine liquid - and today I am trying to split the dose  to see if it helps minimize the side effects (note by CC - possibly means withdrawal effects caused by interdose withdrawal) from mid-afternoon through the evening hours.\n \n\n\n\t \n \n\n\n\t \n "
<https://www.survivingantidepressants.org/topic/283-tips-for-tapering-off-cymbalta-duloxetine/page/4/>