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<http://schema.org/articleBody>
"We report a case of a 22-year-old female patient who was diagnosed with a cribriform-morular variant of papillary thyroid carcinoma  CMV-PTC   While at early ages this thyroid cancer variant is highly suggestive for familial adenomatous polyposis  FAP   there was no family history of FAP  In the tumor biallelic  inactivating APC variants were identified  The patient tested negative for germline variants based on analysis of genomic DNA from peripheral blood leukocytes  Somatic mosaicism was excluded by subsequent deep sequencing of leukocyte and normal thyroid DNA using next generation sequencing  NGS   This report presents a rare sporadic case of CMV-PTC  and to the best of our knowledge the first featuring two somatic APC mutations underlying the disease  with an overview of CMV-PTC cases with detected APC and CTNNB1 pathogenic variants from the literature "
<https://www.mysciencework.com/publication/facets/journal/Familial%2520Cancer>