_:nccd9a3188e3d4ec48f1eea04185c074axb0
<http://schema.org/articleBody>
"To prevent endometrial carcinoma in Lynch syndrome  LS   regular gynecological surveillance visits and prophylactic surgery are recommended  Previous data have shown that prophylactic hysterectomy is an effective means of cancer prevention  while the advantages and disadvantages of surveillance are somewhat unclear  We aimed to evaluate female LS carriers    attitudes towards regular gynecological surveillance and factors influencing their decision-making on prophylactic surgery that have not been well documented  Pain experienced during endometrial biopsies was also evaluated  Postal questionnaires were sent to LS carriers undergoing regular gynecological surveillance  Questionnaires were sent to 112 women with LS  of whom 76 responded  68    Forty-two  55   had undergone prophylactic hysterectomy by the time of the study  The majority of responders  64 76  84 2   considered surveillance appointments beneficial  Pain level during endometrial biopsy was not associated with the decision to undergo prophylactic surgery  The level of satisfaction the women had with the information and advice provided during surveillance was significantly associated with the history of prophylactic hysterectomy  satisfaction rate of 73 2  versus 31 8  of nonoperated women  p   0 003   The women who had undergone prophylactic surgery were older than the nonoperated women both at mutation testing  median of 42 3 years versus 31 6 years  p   0 001  and at the time of the study  median of 56 9 years versus 46 0 years  respectively  p   0 001   Women with LS pathogenic variants have positive experiences with gynecological surveillance visits  and their perception of the quality of the information and advice obtained plays an important role in their decision-making concerning prophylactic surgery "
<https://www.mysciencework.com/publication/facets/journal/Familial%2520Cancer>