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<http://schema.org/articleBody>
"Barrett   s oesophagus  BE  has been associated with an increased risk of both colorectal adenomas and colorectal cancer  A recent investigation reported a high frequency of BE in patients with adenomatous polyposis coli   APC  -associated polyposis  FAP   The aim of the present study is to evaluate the prevalence of BE in a large cohort of patients with MUTYH -associated polyposis  MAP  and APC -associated adenomatous polyposis  Patients with a genetically confirmed diagnosis of familial adenomatous polyposis  FAP  or MAP were selected and upper gastrointestinal  GI  endoscopy reports  pathology reports of upper GI biopsies were reviewed to determine the prevalence of BE in these patients  Histologically confirmed BE was found in 7  9 7   of 72 patients with MAP  The mean age of diagnosis was 60 2  years  range 54 1   72 4  years   Two patients initially diagnosed with low grade dysplasia showed fast progression into high grade dysplasia and esophageal cancer  respectively  Only 4  1 4   of 365 patients with FAP were found to have pathologically confirmed BE  The prevalence of BE in patients with MAP is much higher than reported in the general population  We recommend that upper GI surveillance of patients with MAP should not only focus on the detection of gastric and duodenal adenomas but also on the presence of BE "
<https://www.mysciencework.com/publication/facets/journal/Familial%2520Cancer>