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"&amp;lt;p&amp;gt;Scleredema is a skin disorder in which the skin thickens and hardens, sometimes with redness. What causes scleredema is not known. It is often associated with diabetes, and among people with diabetes, men are affected much more often than women (10:1). Scleredema may occur after a viral illness, or streptococcal throat infection, and in these cases females are affected twice as often as males. Despite being sometimes called scleredema adultorum, the disorder occurs in individuals of all ages and all ethnic backgrounds.&amp;lt;/p&amp;gt;&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Symptoms&amp;lt;/strong&amp;gt;&amp;lt;br/&amp;gt;When scleredema occurs, the affected area of skin becomes thickened and hardened. It may become red or darkened in color, and may look rough like the skin of an orange (called peau d\u2019orange). In most cases scleredema begins on the face, neck, or upper back. It may spread to the arms or chest, but the hands and feet are not usually affected. Other symptoms may occur depending on the area affected:&amp;lt;/p&amp;gt;&amp;lt;ul&amp;gt;&amp;lt;li&amp;gt;face \u2013 difficulty in opening the eyes or mouth&amp;lt;/li&amp;gt;&amp;lt;li&amp;gt;skin over joints \u2013 limited motion&amp;lt;/li&amp;gt;&amp;lt;li&amp;gt;tongue \u2013 difficulty speaking or chewing&amp;lt;/li&amp;gt;&amp;lt;/ul&amp;gt;&amp;lt;p&amp;gt;In some individuals, scleredema affects not just skin but other body parts such as the heart, liver, spleen, muscles, or throat.&amp;lt;/p&amp;gt;&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Diagnosis&amp;lt;/strong&amp;gt;&amp;lt;br/&amp;gt;Scleredema is usually suspected based on the appearance of the skin and the medical history of the individual (such as having diabetes or a recent infection). A skin sample (biopsy) is taken and examined under the microscope to confirm the diagnosis. A throat culture for streptococcal throat infection is obtained and blood glucose is tested for diabetes. A special blood test is done to check for blood disease such as multiple myeloma, which may appear after scleredema begins.&amp;lt;/p&amp;gt;&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Treatment&amp;lt;/strong&amp;gt;&amp;lt;br/&amp;gt;Many different types of medications have been tried as treatments for scleredema, but no one medication has been proven to be best. Individuals may benefit from &amp;lt;a href=&amp;quot;https://www.verywell.com/&amp;quot; data-component=&amp;quot;link&amp;quot; data-source=&amp;quot;inlineLink&amp;quot; data-type=&amp;quot;internalLink&amp;quot; data-ordinal=&amp;quot;1&amp;quot;&amp;gt;corticosteroids&amp;lt;/a&amp;gt;, &amp;lt;a href=&amp;quot;https://www.verywell.com/&amp;quot; data-component=&amp;quot;link&amp;quot; data-source=&amp;quot;inlineLink&amp;quot; data-type=&amp;quot;internalLink&amp;quot; data-ordinal=&amp;quot;2&amp;quot;&amp;gt;cyclosporine&amp;lt;/a&amp;gt;, &amp;lt;a href=&amp;quot;https://www.verywell.com/&amp;quot; data-component=&amp;quot;link&amp;quot; data-source=&amp;quot;inlineLink&amp;quot; data-type=&amp;quot;internalLink&amp;quot; data-ordinal=&amp;quot;3&amp;quot;&amp;gt;methotrexate&amp;lt;/a&amp;gt;, UVA1 phototherapy, or psoralen with ultraviolet light A. If an\u00A0infection is present, antibiotics may be required. If diabetes is present, it should be controlled with diet, exercise, and medication. Physical therapy may help if any\u00A0movement of body parts is restricted.&amp;lt;/p&amp;gt;&amp;lt;p&amp;gt;Individuals who develop scleredema after infection tend to have a shorter course of the\u00A0disease, with symptoms resolving within 6 months to 2 years. Individuals with diabetes who develop scleredema have symptoms for a longer period of time, often many years.&amp;lt;/p&amp;gt;&amp;lt;p&amp;gt;&amp;lt;em&amp;gt;Sources:&amp;lt;/em&amp;gt;&amp;lt;br/&amp;gt;- MedicineNet.com. &amp;lt;a href=&amp;quot;http://www.medterms.com/script/main/art.asp?articlekey&amp;amp;#61;39096&amp;amp;amp;pf&amp;amp;#61;3&amp;amp;amp;page&amp;amp;#61;1&amp;quot; data-component=&amp;quot;link&amp;quot; data-source=&amp;quot;inlineLink&amp;quot; data-type=&amp;quot;externalLink&amp;quot; data-ordinal=&amp;quot;4&amp;quot; rel=&amp;quot;nofollow&amp;quot;&amp;gt;Definition of Scleredema&amp;lt;/a&amp;gt;&amp;lt;br/&amp;gt;- Rosenbach, M. (2006). Scleredema. eMedicine, accessed at http://www.emedicine.com/derm/topic385.htm&amp;lt;/p&amp;gt;"^^<http://www.w3.org/2001/XMLSchema#string>
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