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" What is\u00A0Migraleve pink used for?  Treating\u00A0nausea and headache associated with\u00A0migraine attacks\u00A0that are\u00A0not relieved by paracetamol, ibuprofen or aspirin alone.  If taken at the first sign you are getting\u00A0a migraine, Migraleve pink tablets can prevent the migraine developing fully. How does\u00A0Migraleve pink work? The buclizine in Migraleve pink treats the sensation of nausea that can occur in a migraine attack and thus prevents vomiting. It works by stopping the vomiting centre in the brain from receiving nerve messages that would otherwise cause nausea and vomiting. The paracetamol in Migraleve pink is thought to relieve pain by reducing the production of prostaglandins in the brain and spinal cord. Prostaglandins sensitise nerve endings, causing pain. By reducing their production paracetamol is thought to increase our pain threshold, so that although the cause of the pain remains, we can feel it less. The codeine in Migraleve pink is a slightly stronger painkiller known as an opioid. Opioid painkillers work by mimicking the action of natural pain-reducing chemicals called endorphins that are produced in the brain and spinal cord. Codeine acts on the same opioid receptors as natural endorphins and this blocks the transmission of pain signals sent by the nerves to the brain. This means that even though the cause of the pain may remain, less pain is actually felt. Migraleve pink tablets contain 8mg of codeine, which in combination with the paracetamol, is effective at relieving mild\u00A0pain of migraine headaches.  How do I take Migraleve pink?  Migraleve pink tablets can be taken either with or without food. Adults and adolescents aged 15 years and over should take two Migraleve pink tablets as soon as you know\u00A0that a migraine is starting. Children aged 12 to 14 years should take one Migraleve pink tablet as soon as you know\u00A0that a migraine is starting.  If the migraine continues, further treatment should be with Migraleve yellow tablets to help relieve the migraine headache. You should not start taking Migraleve yellow until four to six hours after your dose of Migraleve pink. Do not take more than the recommended dose. Do not take Migraleve\u00A0for longer than three days without consulting your doctor. Taking codeine regularly for more than three days can lead to addiction to the medicine and withdrawal symptoms when you stop taking it. Consult your doctor if your migraine doesn&amp;#039;t improve despite taking Migraleve.  What should I know before\u00A0taking Migraleve pink?  Migraleve pink may cause drowsiness, dizziness and blurred vision. If you are affected you should not drive or operate machinery and avoid drinking alcohol. In\u00A0March 2015 a new &amp;#039;drug driving&amp;#039; law came\u00A0into force that\u00A0allows\u00A0police to use roadside drug tests to check for the presence of\u00A0prohibited drugs in a driver&amp;#039;s saliva.\u00A0The medicines prohibited\u00A0by the law include morphine. Codeine is converted into morphine by the liver, which means\u00A0it may be an offence to drive while you are taking\u00A0Migraleve pink. You should not drive if you think this medicine affects your ability to drive safely, for example if it makes you feel sleepy, dizzy, unable to concentrate or make decisions, or if you have blurred or double vision.  People can vary considerably in the way that their body metabolises codeine. For some people this may lead to an increased chance of getting side effects, such as reduced levels of consciousness; sleepiness; slow, shallow breathing; &amp;#039;pin-point&amp;#039; pupils; lack of appetite; constipation; or nausea and vomiting. If you experience any of these you should stop using Migraleve pink\u00A0and get medical advice straight away. For other people it may mean that the codeine is less effective, so if you find this medicine doesn&amp;#039;t relieve your symptoms well enough you should consult your doctor or pharmacist.  Do not take Migraleve pink\u00A0with any other products that contain paracetamol. Many over-the-counter painkillers and cold and flu remedies contain paracetamol. It is important to check the ingredients of any medicines you buy without a prescription before taking them with Migraleve pink, or ask\u00A0your pharmacist.   An overdose of paracetamol is dangerous and capable of causing serious damage to the liver and kidneys. You should never exceed the recommended dose\u00A0of Migraleve pink. Get immediate medical advice\u00A0in the event of an overdose with Migraleve pink, even if you feel well, because of the risk of delayed, serious liver damage.  Alcohol increases the risk of liver damage that can occur if an overdose of paracetamol is taken. The hazards of paracetamol overdose are greater in persistent heavy drinkers and in people with alcoholic liver disease.   Do not take Migraleve for longer than three days without consulting your doctor. If you take Migraleve regularly for long periods of time, the body can become tolerant to it and it may become less effective at relieving pain. With prolonged use, the body may also become dependent on the codeine. As a result, when you then stop taking the medicine you may get withdrawal symptoms such as restlessness and irritability.  Taking a painkiller for headaches too often or for too long can actually make the headaches worse.  Who should not take Migraleve pink?\u00A0  People who are known to have a genetic variation of a liver enzyme called CYP2D6, which metabolises codeine into morphine (CYP2D6 ultra-rapid metabolisers). These people are more likely to experience side effects after taking codeine, because they convert more codeine into morphine than other people. See the warning section above. People with very slow, shallow breathing (respiratory depression), people\u00A0having an\u00A0asthma attack\u00A0and people with\u00A0chronic obstructive pulmonary disease (COPD). People with liver failure. People with or\u00A0at risk of getting a blockage in the gut (paralytic ileus).  People with a head injury or raised pressure inside the skull (intracranial pressure). People who are intoxicated with alcohol.  Women who are breastfeeding. Children under 12 years of age. Children and adolescents under 18 years of age who have had surgery to remove their tonsils or adenoids (tonsillectomy or adenoidectomy or both) for obstructive sleep apnoea. Migraleve pink\u00A0is not recommended for adolescents aged 12 to 18 years whose breathing might be compromised, including those with neuromuscular disorders; severe heart or lung conditions; upper airway or lung infections; multiple trauma; or who have had extensive surgical procedures.   Migraleve pink\u00A0should not be used if you are allergic to any of its ingredients.\u00A0If you feel you have experienced an allergic reaction, stop using Migraleve pink\u00A0and inform your doctor or pharmacist immediately.  Who should get medical advice before using Migraleve pink?  Elderly people. People with kidney or liver problems. People with lung problems such as\u00A0asthma\u00A0or\u00A0a condition called bronchiectasis, in which there is persistent widening of the airways as a result of lung disease, eg infection, inflammation, tumours or cystic fibrosis. People with biliary tract disorders, eg gallstones or recent surgery on the biliary tract. People with acute abdominal conditions such as appendicitis. People who have recently had surgery on the stomach, intestines or urinary tract. People who are constipated. People with inflammatory bowel disorders such as Crohn&amp;#039;s disease or ulcerative colitis. People who have difficulty passing urine, for example men with an enlarged prostate gland. People with an underactive thyroid gland (hypothyroidism). People with underactive adrenal glands, eg Addison&amp;#039;s disease. People with low blood pressure (hypotension) or shock. People with a condition involving abnormal muscle weakness called myasthenia gravis. People with a history of convulsions or fits, eg epilepsy. People with an irregular heartbeat (arrhythmia). People with a history or risk of narrow angle glaucoma. People with a history of drug abuse or dependence.  Can I take Migraleve pink while pregnant or\u00A0breastfeeding?  Get\u00A0medical advice from your doctor before using Migraleve pink if you are pregnant.\u00A0Migraleve pink should be avoided during pregnancy and the late stages of labour, unless considered essential by your doctor, and then used\u00A0only if the expected benefit to the mother outweighs any potential risk to the baby.\u00A0Paracetamol is not known to be harmful when used during pregnancy, however the safety of buclizine and codeine during pregnancy\u00A0have\u00A0not been fully\u00A0established. If codeine is used regularly in the third trimester it may cause withdrawal symptoms in the baby after birth. If used during labour it may cause breathing difficulties in the baby after birth.\u00A0 If you are breastfeeding you should not take Migraleve pink.\u00A0It is not known if buclizine passes into breast milk. Paracetamol and codeine may pass into breast milk in amounts that are probably too small to be harmful in most people. However, because some people metabolise codeine in a slightly different way that can increase the risk of getting side effects from the medicine, it is recommended that women who are breastfeeding do not take codeine. It is impossible to predict which women and babies will metabolise codeine differently. Potential side effects in a nursing baby may include drowsiness or sedation, difficulty breastfeeding, vomiting, breathing difficulties and floppiness.\u00A0  What are the possible side effects of Migraleve pink? Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with paracetamol, codeine and buclizine. Just because a side effect is stated here does not mean that all people using Migraleve pink will experience that or any side effect.  Drowsiness. See warnings above. Dizziness. Constipation. Nausea and vomiting. Dry mouth. Sweating. Itching. Skin rash. Difficulty passing urine. Headache. Confusion. Blurred vision. Dependence on the medicine if used regularly or for long periods of time (see warning section above).  Talk to your doctor\u00A0or pharmacist if you want any more information about the possible side effects of Migraleve pink, or read the leaflet provided with the medicine. If you think you have experienced a side effect, did you know you can report this using the\u00A0yellow card website? Can I take Migraleve pink with\u00A0other medicines? If you are taking any other medicines, including those bought without a prescription and herbal medicines, it is important to check with your pharmacist or doctor\u00A0before you take Migraleve pink\u00A0as well, to make sure that the\u00A0combination is safe. Migraleve pink\u00A0should not be taken by people who have taken\u00A0a monoamine oxidase inhibitor (MAOI) medicine\u00A0in the last 14 days.\u00A0MAOIs include the antidepressants\u00A0phenelzine,\u00A0tranylcypromine,\u00A0isocarboxazid\u00A0and\u00A0moclobemide\u00A0and the anti-Parkinson&amp;#039;s medicine\u00A0selegiline.   Don&amp;#039;t take\u00A0other medicines that contain paracetamol\u00A0in combination with Migraleve, as this can easily result in exceeding the maximum recommended daily dose of paracetamol. Many\u00A0cold and flu remedies\u00A0and\u00A0other painkillers\u00A0contain paracetamol so be sure to check the ingredients of any other medicines before taking\u00A0with this one, or ask your pharmacist for advice. (Paracetamol is known as acetaminophen in the USA and some other countries). It is fine to take Migraleve pink\u00A0with ibuprofen. Migraleve pink\u00A0may cause drowsiness. This is more likely if you take it\u00A0with any of the following, which can also cause drowsiness:  antipsychotics, eg haloperidol, chlorpromazine  benzodiazepines, eg temazepam, diazepam  sleeping tablets, eg zopiclone  other sedating antihistamines, eg chlorphenamine, promethazine, triprolidine, hydroxyzine (some of these may be found in non-prescription cough and cold or hayfever remedies)  other strong opioid painkillers, eg dihydrocodeine, morphine, tramadol   tricyclic antidepressants, eg amitriptyline.   Codeine \u00A0can reduce the muscular activity in the gut and so may oppose the effect of the following medicines on the gut:  domperidone  metoclopramide.  There may be an increased risk of side effects such as constipation, dry mouth and blurred vision if Migraleve pink\u00A0is taken with antimuscarinic medicines that can cause these type of side effects, such as the following:   antimuscarinic medicines for Parkinson&amp;#039;s symptoms, eg procyclidine, orphenadrine, trihexiphenidyl   antimuscarinic medicines for urinary incontinence, eg oxybutynin, flavoxate, tolterodine, propiverine, trospium  antispasmodics, eg atropine, hyoscine.  There is a risk of severe constipation if codeine is used with antimotility medicines for diarrhoea, such as loperamide. Quinidine, rifampicin\u00A0and\u00A0ritonavir\u00A0may reduce the painkilling\u00A0effects of codeine. Colestyramine\u00A0reduces the absorption of paracetamol from the gut. It should not be taken within an hour of taking Migraleve pink\u00A0or the effect of the paracetamol will be reduced. Other medicines containing the same active ingredients Migraleve\u00A0contains a combination of Migraleve pink and Migraleve yellow tablets. Last updated 18.02.2015 "^^<http://www.w3.org/2001/XMLSchema#string>
<http://www.netdoctor.co.uk/medicines/aches-and-pains/a8076/migraleve-pink-paracetamol-codeine-and-buclizine/>