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"   Question I have all known the conditions associated with the HLA B27 gene, namely ulcerative colitis, iritis, psoriasis, labyrinthitis, thyroid tumour and finally ankylosing spondylitis.   The one that bothers me most is the ankylosing spondylitis.  I burnt out over 10 years ago, but retain the legacy of reduced joint movement.  Now I have slight numbness and tingling in both hands.  Could this be related to the calcification of my vertebrae?    Answer You certainly do have a full house of HLA B27 associated conditions so it&amp;#039;s good news that at least the active process of the ankylosing spondylitis (AS) has burned out.  The lower spine and sacroiliac joints are usually affected more than the neck, but the general alteration that may occur in the spinal curvatures can cause neck problems.  It is certainly possible that your neck vertebrae might be involved in the disease process, since AS does affect the cervical spine.  This could lead to compression of some of the nerves supplying your hands causing tingling and numbness.   It could just be that stiffness in the rest of your back is causing your posture to result in the symptoms that you describe.  Really, you will only find the answer to your query through further X-rays of your neck.  Either way, exercises and physiotherapy will be helpful in alleviating the symptoms.  You may have previously done a lot of physiotherapy, but do not be shy about asking for further assessment of your joints and mobility, and help in getting the maximum range of movement in your spine and limbs.  Yours sincerely The NetDoctor Medical Team  Other Qs &amp;amp;amp; As Chiropractor vs osteopath Choosing the right osteopath I have high potassium levels. What does this mean? I&amp;#039;ve had two bone density scans in 17 months I will be referred to a rheumatologist Orthopaedic doctor What is a bone density test? What will the orthopaedic surgeon suggest for my hips? X-ray to investigate a prolapsed disc  Last updated 25.09.2014 "^^<http://www.w3.org/2001/XMLSchema#string>
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