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" What is it used for?  Fever (pyrexia) Mild to moderate pain   How does it work? Paracetamol is a medicine used in the treatment of mild to moderate pain. It is also useful for reducing fever. It is not fully understood how paracetamol produces these effects. Paracetamol is broken down to toxic compounds which are normally neutralised by a substance in the liver called glutathione. Glutathione is only produced in limited amounts, so the body cannot neutralise the excessive toxins resulting from a paracetamol overdose. This leads to liver damage. Methionine is a substance obtained from the diet and used by the body to produce glutathione. It is included in this medicine to ensure levels of glutathione in the liver are maintained in order to minimise the liver damage caused if a paracetamol overdose is taken.   Warning!  In cases of overdose, seek immediate advice from a doctor. Alcohol increases the risk of liver damage that can occur if an overdose of paracetamol is taken. The hazards of paracetamol overdose are greater in persistant heavy drinkers and in people with alcoholic liver disease.   Use with caution in  Alcoholism Decreased kidney function   Not to be used in  Children under 12 years of age Known sensitivity or allergy to any ingredient Liver disease  This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.  If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.   Pregnancy and Breastfeeding Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.  This medicine should be used with caution during pregnancy, and only if the expected benefit to the mother is greater than any possible risk to the foetus. Seek medical advice from your doctor. This medicine should be used with caution by breastfeeding mothers, and only if the expected benefit to the mother is greater than any possible risk to the baby. Seek medical advice from your doctor.   Label warnings  Do not take more than 2 at any one time. Do not take more than 8 in 24 hours. Do not take this medication with any other products containing paracetamol.   Side effects Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.  Blood disorders Skin rashes  The side effects listed above may not include all of the side effects reported by the drug&amp;#039;s manufacturer.  For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.   How can this medicine affect other medicines? This medicine should not be used with monoamine-oxidase inhibitor (MAOI) antidepressants (e.g. phenelzine)   Prolonged use of paracetamol may enhance the effects of anti-clotting/ blood thinning medicines such as warfarin, leading to an increased risk of bleeding.   Methionine may reduce the effect of levodopa.   Metoclopramide and domperidone increase the rate of absorption of paracetamol from the gut.   The absorption of paracetamol is decreased if cholestyramine is taken at the same time.  Last updated 08.07.2004 "^^<http://www.w3.org/2001/XMLSchema#string>
<http://www.netdoctor.co.uk/medicines/aches-and-pains/a7316/paradote-discontinued-in-the-uk/>