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"What is it used for?  Treating blood clots in the veins of the leg (deep vein thrombosis). Treating blood clots in the lungs (pulmonary embolism).  Preventing these types of blood clots (thromboembolic disorders), particularly following general surgery or surgery on the bones (orthopaedic surgery), or in people bedridden due to illness. Treating blood clots in the coronary arteries in unstable angina and heart attack (myocardial infarction). Preventing blood from clotting when it is filtered through an &amp;#039;artificial kidney&amp;#039; (haemodialysis) machine as part of the management of kidney failure.  How does it work? Clexane injection contains the active ingredient enoxaparin, which is a type of medicine called a low molecular weight heparin. It is used to stop blood clots forming within the blood vessels. Blood clots normally only form to stop bleeding that has occurred as a result of injury to the tissues. The clotting process is complicated and begins when blood cells called platelets clump together and produce chemicals that activate the clotting process. The final part of this process involves a substance called thrombin being activated to produce a protein called fibrin. Fibrin binds the platelets together, forming a blood clot. This is the body&amp;#039;&amp;#039;s natural way of repairing itself.  Sometimes, however, a blood clot can form abnormally within the blood vessels. This is known as a thrombus. It can be dangerous because the clot may detach and travel in the bloodstream, where it becomes known as an embolus. The embolus may eventually get lodged in a blood vessel, thereby blocking the blood supply to a vital organ such as the heart, brain or lungs. This is known as a thromboembolism.  Some people have an increased tendency for blood clots to form within the blood vessels. This is usually due to a disturbance in the blood flow within the blood vessels. For example, in coronary artery disease, fatty deposits (atherosclerosis) on the walls of the coronary arteries can disrupt the blood flow, giving a tendency for platelets to clump together and start off the clotting process. When a clot has formed in a coronary artery this reduces the flow of blood to the heart and causes chest pain (angina). It can also result in a heart attack.  Slow blood flow in the leg and pelvic veins can also result in clots forming in these veins (deep vein thrombosis). These clots can break off and travel to the lungs (pulmonary embolism). Being immobile for long periods of time, for example due to a severe medical condition or following surgery, can increase the risk of these types of blood clot, as can pregnancy, obesity and certain blood disorders.  Enoxaparin is used to prevent and treat these types of abnormal blood clots. It works by inactivating thrombin in the clotting process described above. This stops the formation of fibrin, the essential component of blood clots.  Enoxaparin can also be used to prevent blood clotting when it is filtered through a kidney dialysis machine. How is it given?  Clexane is administered by injection under the skin of the abdomen (subcutaneous injection). The dose and length of treatment used will depend on the nature of the clot being treated or prevented.  Warning!  During treatment with this medicine you may need to have regular blood tests to monitor the numbers of blood cells called platelets in your blood.  Your doctor may also want to monitor the level of potassium in your blood while you are having this medicine, particularly if treatment lasts for longer than seven days.  Use with caution in  People over 80 years of age. People who are underweight or overweight. People with decreased kidney function or chronic kidney failure. People with decreased liver function. People who have previously developed a reduced platelet count in the blood due to treatment with heparin or low molecular weight heparin (heparin-associated thrombocytopenia). People with problems stopping bleeding. People with a history of peptic ulcer. People who have recently had a stroke caused by a blood clot in the brain (ischaemic stroke). Severe uncontrolled high blood pressure (hypertension). Diabetes. Diabetes affecting the eyes (diabetic retinopathy). People who have recently had eye surgery. People who have recently had surgery on the brain or spinal cord (neurosurgery). People having spinal or epidural anaesthesia. People with a high level of potassium in their blood (hyperkalaemia).  People with increased acidity in their blood (metabolic acidosis).  Not to be used in  People who are allergic to heparin or other low molecular weight heparins. People with a bacterial infection of the heart valves and the lining surrounding the heart (bacterial endocarditis). People with active major bleeding. People with conditions that carry a high risk of uncontrolled bleeding, for example the blood clotting disorder haemophilia, or the conditions listed below: Active peptic ulcer. Recent stroke caused by bleeding in the brain (haemorrhagic stroke). Reduced platelet count in the blood (thrombocytopenia). This medicine is not recommended for use in children. This medicine is not recommended for preventing blood clots in people with an artificial heart valve.  This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy. If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately. Pregnancy and breastfeeding Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.  This medicine is not licensed for use during pregnancy. However, the medicine does not cross the placenta and so does not enter the baby&amp;#039;s bloodstream. It is not known to be harmful if used during pregnancy. Low molecular weight heparins such as this one are often used to prevent and treat blood clots in pregnant women. However, the medicine is not recommended for preventing blood clots in pregnant women with artificial heart valves, because there is insufficient information regarding its use in this particular case. Seek further medical advice from your doctor.  This medicine has not been studied in women who are breastfeeding. However, it is unlikely to pass into breast milk and even if it did, it would be inactivated in the gut of the baby. The medicine is not expected to be harmful to a nursing infant if it is used to treat mothers who are breastfeeding. Seek further medical advice from your doctor.   Side effects Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect.  Bleeding. It is important to tell your doctor straight away if you notice any signs of bleeding while you are receiving treatment with this medicine, for example nosebleeds, bruising, coughing up or vomiting blood, blood in your urine, or black, tarry or bloodstained stools. Pain and irritation at the injection site. Blood clots which form a solid swelling at the injection site (haematoma). Decrease in the number of platelets in the blood (thrombocytopenia). Major bleeding (haemorrhage), for example in the abdomen or inside the skull. Alteration in results of liver function tests. Raised blood potassium level (hyperkalaemia). Death of skin cells (necrosis) at the site of injection. Blood clots in the spinal cord (intraspinal haematoma) in people also having spinal or epidural anaesthesia.  Osteoporosis (a reduction in bone density leading to bones which may fracture easily) has occurred after long-term treatment with a similar medicine called heparin. Although this has not been observed in people treated with Clexane, it is possible that this could happen with Clexane.   The side effects listed above may not include all of the side effects reported by the medicine&amp;#039;s manufacturer. For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist. How can this medicine affect other medicines? It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while having treatment with this one, to make sure that the combination is safe.  There may be an increased risk of bleeding or increased time taken to stop bleeding, if this medicine is used in combination with medicines that affect blood clotting, such as the following:   antiplatelet (&amp;#039;blood-thinning&amp;#039;) medicines, such as aspirin, dipyridamole, clopidogrel clot-busting medicines (fibrinolytics) such as streptokinase, alteplase dextran iloprost non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, diclofenac, naproxen (do not take this type of painkiller while you are having treatment with this medicine unless you have discussed it with a doctor or pharmacist first)  oral anticoagulants, such as warfarin, nicoumalone, phenindione, dabigatran, rivaroxaban, apixaban.  There may be an increased risk of a rise in the amount of potassium in your blood if this medicine is used in combination with any of the following:   ACE inhibitors, eg captopril, lisinopril aliskiren ciclosporin potassium-sparing diuretics, eg spironolactone, triamterene, amiloride potassium supplements  potassium-containing salt substitutes.   The amount of potassium in your blood should be regularly monitored if you are taking any of these during treatment with this medicine.  Other medicines containing the same active ingredient There are currently no other medicines available in the UK that contain enoxaparin as the active ingredient. Last updated 13.01.2014 "^^<http://www.w3.org/2001/XMLSchema#string>
<http://www.netdoctor.co.uk/medicines/heart-and-blood/a6416/clexane-enoxaparin/>