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" What is it used for?  Muscle pain. Rheumatic pain. Backache. Sprains, strains and sports injuries. Pain from non-serious arthritic conditions. Severe throbbing or stabbing pain along a nerve and in the area supplied by the nerve (neuralgia).   How does it work? Ibuleve gel, maximum strength gel, mousse and spray all contain the active ingredient ibuprofen, which is a type of medicine called a non-steroidal anti-inflammatory drug (NSAID). Ibuprofen is a simple painkilling medicine used to relieve mild to moderate pain and inflammation.  Ibuprofen works by blocking the action of a substance in the body called cyclo-oxygenase (COX). Cyclo-oxygenase is involved in the production of various chemicals in the body, some of which are known as prostaglandins. Prostaglandins are produced in response to injury and certain diseases and conditions, and cause pain, swelling and inflammation. Ibuprofen blocks the production of these prostaglandins and is therefore effective at reducing inflammation and pain.  When ibuprofen is applied to the skin (topical application) it is absorbed through the skin into the underlying tissues, where it reduces pain and inflammation in the local area.  Ibuleve gels, mousse and spray can be used to relieve the pain of muscular and joint conditions such as sprains, strains, backache, rheumatism and minor arthritic conditions. They should be massaged gently into the affected area. Ibuprofen is absorbed less into the bloodstream from preparations that are applied to the skin than from preparations that are taken by mouth (see end of factsheet), however absorption can still occur, particularly if large amounts are used on large areas.    Warning!  This medicine is for external use only. Ibuleve spray and mousse are flammable and should not be used near or placed in direct contact with sources of heat (eg open flames, electric heaters, lit cigarettes).  Do not apply to broken skin. Avoid contact with the eyes and the moist membranes lining the inside of certain parts of the body, eg mouth, nasal passages (mucous membranes). Rinse with cold water if accidental contact occurs. Wash your hands thoroughly after applying this medicine, unless the hands are the area being treated. You should not cover the area being treated with airtight dressings, as these will enhance the absorption of the medicine into the body and may increase the risk of side effects. This medicine should not be used for longer than a few weeks unless otherwise advised by your doctor. Seek medical advice from your doctor or pharmacist if your symptoms persist or worsen despite treatment. If you experience any side effects from this medicine, in particular a rash, stop using it and seek medical advice.   Use with caution in  Active peptic ulcer. Asthma. History of kidney disorders. Intolerance to aspirin, ibuprofen or other related painkillers (NSAIDs) taken by mouth.   Not to be used in  Broken, damaged, infected or diseased skin. People in whom aspirin or other medicines in this class (NSAIDs), cause attacks of asthma, itchy rash (urticaria) or nasal inflammation (rhinitis). Ibuleve preparations are not recommended for children under 12 years of age unless instructed by a doctor.  This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.  If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.   Pregnancy and breastfeeding Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.  This medicine should not be used in pregnancy unless considered essential by your doctor, as sufficient may be absorbed to affect the baby. When used in the third trimester ibuprofen may delay labour, increase the length of labour and cause complications in the newborn baby. Seek medical advice from your doctor.  The manufacturer of this medicine recommends that mothers should avoid using this medicine while breastfeeding. However, ibuprofen taken by mouth passes into breast milk in such small quantities that it is unlikely to harm the baby, hence topical ibuprofen is also unlikely to be harmful. As with all medicines, seek medical advice from your doctor before using this medicine if you are breastfeeding.   Side effects Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.  Skin rashes. Abdominal pain. Indigestion (dyspepsia). Allergic reactions such as asthma, narrowing of the airways (bronchospasm), swelling of the lips, throat and tongue (angioedema), itchy blistering rash or anaphylactic shock.  The side effects listed above may not include all of the side effects reported by the drug&amp;#039;s manufacturer.  For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.   How can this medicine affect other medicines? When it is used on unbroken skin this medicine is unlikely to be absorbed in sufficient amounts to affect other medicines that are being taken by mouth. However, if it is used with aspirin or other NSAIDs, eg ibuprofen taken by mouth, there may be an increased chance of side effects. For more information about the interactions of ibuprofen taken by mouth see the factsheets linked below.    Other medicines containing the same active ingredient    Cuprofen gel Fenbid gel Ibugel   Ibumousse Ibuspray Mentholatum ibuprofen gel   Nurofen gel Phorpain gel Proflex cream   Radian B ibuprofen gel/massage stick         Anadin ibuprofen Anadin ultra Arthrofen   Brufen Calprofen Cuprofen   Cuprofen for children Fenbid spansules Fenpaed   Galprofen Hedex ibuprofen Ibufem    Librofem  Migrafen Nurofen   Nurofen for children Orbifen for children     Other brands of ibuprofen that are applied to the skin: Brands of ibuprofen that are taken by mouth: Ibuprofen tablets, capsules, caplets and suspensions are also widely available without brand names, ie as the generic medicine.  The quantity and strength of ibuprofen supplied in the container or packet will determine whether it is only available on prescription, or can be bought from pharmacies only, or from other retail outlets such as supermarkets and garages.   Last updated 27.08.2007 "^^<http://www.w3.org/2001/XMLSchema#string>
<http://www.netdoctor.co.uk/medicines/aches-and-pains/a6893/ibuleve-ibuprofen/>