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"Delivering wrinkle-softening injectables, such as Restylane and Botox, topically without shots is a reality and could soon be widely available, says Mark S. Nestor, a dermatologist in Aventura, Florida. In a three-month trial he did with Glynis Ablon, a dermatologist in Manhattan Beach, California, 100 patients applied daily either a placebo cream or one containing the hylauronic acid wrinkle filler Restylane and nanoparticles\u2014FDA-approved materials (made by Transdermal Corp) that are small enough to transport ingredients through tiny skin pores. The Restylane delivered this way was found to smooth fine lines around the eyes and mouth as effectively as injections, but without pain or redness. Transdermal wrinkle softeners \\\"will not replace injections for filling deeper lines or puffing up cheeks and lips,\\\" Nestor says."^^<http://www.w3.org/2001/XMLSchema#string>
<http://www.allure.com/story/no-needles>