Workers fighting to save the historic Boddingtons brewery in Manchester have abandoned their campaign.
Beer has been brewed at Strangeways for 226 years
The Transport and General Workers Union ended its bid to save the 226-year-old Strangeways brewery claiming the management refused to listen.
Union spokesman Franny Joyce said: "Despite our campaign which exposed the management's myths, unfortunately the closure will go ahead next month."
Brewers Interbrew welcomed the decision and said the beer still had a future.
Interbrew, which announced its closure plans in September 2004, aims to move its cask ale production in Manchester to Hydes Brewery, Moss Side.
But the majority of production work will be moving to Lancashire, Scotland and Wales.
Workers lobbied the firm's parent company in Belgium to save the plant and enlisted real ale campaigners and celebrities in their campaign to save the plant.
"The support from the people of Manchester has been terrific and we would like to thank them for the solidarity they have shown us," said Mr Joyce.
"Boddingtons doesn't deserve their support and as far as we're concerned the 'B' in Boddingtons stands for betrayal."
Philip Malpass spokesman for Interbrew said: "Obviously, there's not going to be a change of mind.
"But there really is a future for Boddingtons in Manchester - any boycott would damage a local brewery, which would be a shame."