Leeds, Bath, Worcester and Sale all won over the weekend to top their European Challenge Cup pools and close in on quarter-final places.
Leeds ran in seven tries against Calvisano - including a hat-trick for full-back Leigh Hinton - in a 45-5 win.
Tom Biggs scored after four minutes, as did Hinton moments later.
Back row John Dunbar was the next on to the scoresheet. Former Italy A fly-half Alberto di Bernardo added five conversions in all.
Sale are now the only side in the tournament with a perfect 15 points out of 15 after three rounds after Saturday's 51-12 mauling of Bayonne.
Chris Mayor and Rory Lamont both grabbed try doubles in France as the Sharks ran in eight tries in all.
Former England back-rower Pat Sanderson scored a 20-minute hat-trick of tries as Worcester crushed GRAN Parma 50-0 in awful conditions at Sixways.
The eight-try win gives the Warriors an almost unassailable lead in Pool Two, and with 14 points from a possible 15 they are on target for a home quarter-final in April.
On Friday Newcastle lost 16-13 on their trip to Irish province Connacht.
Jonny Wilkinson converted Tom May's first-half try and hit two penalties but Connacht kept in touch through a converted Conor O'Loughlin try.
Fly-half Andy Dunne dropped a goal to level at 13-13, and slotted a late penalty to seal the win and narrow the gap to the Falcons, the pool leaders.
Bath beat minnows Albi 26-18 to lead Pool One with three wins out of three.
Newcastle, who gave a debut to former All Blacks prop Carl Hayman, are still odds-on to top Pool Three but have games against Brive and a return match against Connacht to come.
Brive's 71-0 victory over Centransa El Salvador gave them a bonus point for a total of 10 after three matches - one ahead of the Falcons.