Sheffield Eagles (10) 34 Tries: Yere, Barnett 3, Rowe, Lindsay Goals: Stringer 2 Wigan Warriors (28) 50 Tries: Richards, Gleeson, Carmont, Paleaaesina, O'Loughlin, Tomkins 3, Coley Goals: Richards 6
Aston played a key role in Sheffield's Wembley win over Wigan in 1998
Wigan eased into the last 16 of the Challenge Cup after being given a brief reminder of one of the most painful moments in their illustrious history.
After Wigan led inside a minute through Pat Richards, Sheffield hit back with two tries in five minutes from centre Menzie Yere and winger Richie Barnett.
But Wigan ensured there would be no repeat of their infamous 18-7 Wembley final defeat to Sheffield in 1998.
Sam Tomkins crossed three times as the Warriors ran in eight more tries.
Sheffield coach Mark Aston, his side's star player winning the Lance Todd Trophy when he played at scrum-half in that shock Wembley victory 12 years ago, was only briefly in dreamland.
Centre Martin Gleeson's try, converted by Richards (one of seven successful kicks for the Super League top points scorer), ensured that Wigan were only behind for seven minutes.
Gleeson's fellow centre George Carmont, substitute Iafeta Paleaaesina and stand-off Sean O'Loughlin then scored three tries in seven minutes to earn Wigan a 28-10 lead at the break.
And another blitz of three more tries early in the second half through scrum-half Sam Tomkins, who bagged two of them, and sub Andy Coley, sent Wigan clear.
Barnett pulled one back for the Eagles with his second try, to which Tomkins responded with a third try, Richards adding the extras to take Wigan to the 50-point mark.
But, although well beaten, Aston's Eagles at least had the character to finish strongly, running in three late tries through Alex Rowe, Barnett, who completed his hat-trick, and Brendon Lindsay.
Wigan coach Michael Maguire told BBC Radio Manchester:
"I was pretty disappointed with the score, it was very different to what we've had in the last few, so that's something we need to look at."
"But I knew if we could play the way we can then the opportunities would come.
"We made it a tough game by the way we performed, but credit to the Sheffield team they played very well."
Sheffield Eagles: Taulapapa, Thackeray, Ropati, Yere, Barnett, Lindsay, McDonald, Howieson, Cook, Stringer, Szostak, Green, Hirst. Replacements: Mossop, Barlow, Rowe, Haley. Wigan Warriors: Phelps, Goulding, Gleeson, Carmont, Richards, O'Loughlin, S Tomkins, Fielden, Riddell, Prescott, Bailey, J Tomkins, Mossop. Replacements: Coley, Paleaaesina, McIlorum, Farrell. Att: 2,950.
Referee: Ian Smith (Australia).