Jolie and Pitt had their twins in a French hospital earlier this month
Two paparazzi clashed with bodyguards after they were found hiding in the grounds of Angelina Jolie and Brad Pitt's French holiday home.
Tony Webb, head of security guarding the Chateau Miraval estate, said the incident took place on Thursday.
One of the photographers, dressed in camouflage gear, "went berserk" while being escorted off the estate, he said.
Jolie and Pitt have been staying at the estate since the birth of their twins earlier this month.
Mr Webb said: "We tried to escort them off the property and the guy's just gone beserk, thrashing out, kicking and actually biting one of the security people, breaking his finger, drawing blood and screaming that he had Hepatitis C."
The couple are staying at the 500-hectare estate in the south of France
Jolie and Pitt have reportedly sold exclusive picture rights to the first photographs of their newborn twins, Vivienne Marcheline and Knox Leon, to a US magazine publication for $11m.
Money from the sale will be donated to charity.
The couple have four other children - six-year-old Maddox, Pax, aged four, and three-year-old Zahara - who are all adopted, and two-year-old daughter Shiloh.
Pitt's lawyers recently threatened legal action against magazines or websites who publish recent pictures taken by paparazzi of the actor and his family at the estate.
Mr Webb warned they would also take action against photographers.
"The family are really fed up that these people are trespassing so we're going to try to get restraining orders and use the law to do whatever we have to to keep them off the property," he said.
An officer at the police station in nearby Brignoles village confirmed that an incident involving paparazzi had taken place at the property.