Colin Hendry has resigned as manager of Clyde with immediate effect.
Hendry took over at Broadwood in June 2007
A club statement said: "Clyde Football Club regrets to announce the resignation of Colin Hendry on compassionate grounds.
"We wish to place on record our gratitude to Colin for his outstanding loyalty and contribution, and wish him and his family well in the future."
Hendry previously took time out of football to look after his ill wife, but now his father is also unwell.
Dougie Bell takes charge for Saturday's match at home to Dundee.
Former Rangers coach John Brown and current Clyde youth team coach Gary Bollan are among the early candidates to take over.
Hendry, who captained the Scots in the 1998 World Cup finals in France, arrived at Clyde in the close season, relishing the prospect of a return to club management in Scotland.
However, he now departs with the Bully Wee currently ninth in Division One.
Hendry's last game in charge was the 1-0 Scottish Cup fourth-round defeat at home to Dundee United on 16 January.