Chief executive David Gill insists the resignations of two senior directors will not affect Manchester United.
Anson (left) was a key player in the latest shirt deal
Gill admitted he was sorry to lose finance director Nick Humby and commercial director Andy Anson, who will leave the club in February.
But Gill told MUTV: "This won't affect the business in any way, Manchester United is not just about two people.
"We would have preferred this had not happened but we will move on, we still have a great future ahead of us."
Humby and Anson tendered their resignations on Tuesday, but will remain in post until the new year.
The pair, along with Gill, are the only directors that are not members of the Glazer family.
They helped bridge the gap between the previous plc board and the new ownership structure under American tycoon Malcolm Glazer.
Gill added: "Nick and Andy have made a great contribution to the success of Manchester United over the last few years.
"I recognise they wanted to move on for new challenges.
"It's strange they are both leaving at the same time, but you cannot legislate for that.
"We have many people here with many years' experience with the club.
Man Utd has been around for many years and will continue to be successful
Chief executive David Gill
"Manchester United has been around for many years and will continue to be successful.
"We have started off the season very strongly and are selling out the ground every week," added Gill, who said the process of finding replacements would start immediately.
Humby, who joined United in 2002, was responsible for delivering the new stadium expansion on time.
Anson, who arrived in 2004, helped negotiate a record £56.5m shirt sponsorship deal with American banking giant AIG.
Fans' group Manchester United Supporters Trust (MUST) - formerly Shareholders United - who bitterly opposed the Glazer takeover, have urged Humby and Anson to let supporters know what is happening at the club.
"Now is the time for them to come clean, do the honourable thing and let the supporters know what is going on behind the scenes at our football club," said MUST spokesman Sean Bones.
"At the time of the takeover, Joel Glazer said he would speak to the supporters. They have not done so, which is a shame because we have a lot of questions for them to answer."