Miss Piggy and two of England's cricket heroes were among celebrity onlookers at designer Julien Macdonald's show at the start of London Fashion Week.
Three anti-fur activists also disrupted the launch of his spring and summer collections at the Natural History Museum.
They held signs saying "Fur kills" and "Fur is dead".
Merthyr Tydfil-born Macdonald launched a collection of luxury furs last season although none were in this show.
Two of England's Ashes heroes, batsman Kevin Pietersen and bowler mate Simon Jones, watched the show, which took the theme of a Spanish villa holiday.
A surprise guest was Muppet Miss Piggy, who wore a Macdonald creation.
"She loves Julien, he designed her dress," said a spokeswoman for the blonde-haired pig, who was wearing a black sequin number, fitted with a luminous pink feather boa.
The show was briefly interrupted by the demonstrators, from the campaign group People for the Ethical Treatment of Animals (Peta).
A protester interrupts the fashion show before being led away
Initially, two campaigners ran on the stage shouting with placards and at the end of the show - when the designer himself was on the catwalk - a third protester ran on to the stage with a sign saying "Macdonald Fur Scum".
Macdonald, who was wearing a sequinned Union Jack blazer and jeans, looked more amused and surprised than angry by the outburst during a collection launch which included bright patterns, colours and fabrics.
He told reporters afterwards said: "There are far more important things to worry about like the tsunami and what happened in New Orleans than worrying about a fur coat and a dead animal."
But Sean Gifford, a spokesman for Peta, said: "Heartless greedy designers like Julien Macdonald may not care about electrocuting animals and ripping off their fur for fashion, but decent compassionate people do.
"Millions of animals suffer on fur farms and in steel traps in the wild. The cruelty of the pelt pushers must end."
Scotland Yard said there had been no police involvement.
In February, Macdonald, who is designer to stars including Kylie Minogue and Martine McCutcheon, was criticised by Peta for using fur in his collection at the opening of London Fashion Week.