Great Britain's Davis Cup captain John Lloyd has named his four-man team for the World Group first-round tie against Argentina starting on 8 February.
Murray is Britain's only player inside the world's top 100
Andy Murray, Jamie Murray, Jamie Baker and Alex Bogdanovic will face the third seeds on clay at the 15,000-capacity Estadio Parque Roca in Buenos Aires.
"It will be the toughest challenge of their career so far for every player in the team," said Lloyd.
Britain reached the elite World Group with victory over Croatia in September.
We need a firm referee - I'm not looking for trouble, but you need a firm referee in those circumstances
But a repeat against the 2006 finalists, who boast 11 top 100 players including David Nalbandian, Guillermo Canas, Juan Ignacio Chela and Juan Monaco, is considered highly unlikely.
Britain have not won a World Group tie since Lloyd, Jeremy Bates and Colin Dowdeswell defeated Spain in 1986.
Furthermore, Andy Murray is Britain's only player inside the top-100 but he has enjoyed scant success on clay.
Bogdanovic, meanwhile, lost in the first round of an ATP Challenger on green clay in Miami this week.
Lloyd, who is holding a training camp in Vina del Mar a week before the tie, admits that his side face a "formidable" challenge against a nation backed by an excitable home crowd.
"We need a firm referee. I'm not looking for trouble, but you need a firm referee in those circumstances," he said.
"A ref can silence a crowd easily enough if he isn't scared of dying. If he does it more than once, it's a point penalty for the hosts. Then it's a game penalty. That stops the crowd pretty quickly.
"None of our team will have played in those circumstances, but we'll have to discuss what might happen and how to go about it."
The sides have met three times previously - the last in 1989 when Argentina ran out 3-2 winners in Eastbourne.
The winner of this year's tie will reach the quarter-final stages of the competition while the loser will play a World Group play-off tie in September.