Right-back Panucci has played for some of Europe's biggest clubs and will have to call upon that experience to limit the threat of Seol on the left wing.
Seol has the pace, skill and determination to worry Italy and the fact that he has yet to hit top form in the World Cup bodes ominously for Panucci.
Seol has shown glimpses of his talent but will have to be at the top of his game against a player who will be out to frustrate him out of the game.
Yoo Sang-Chul v Francesco Totti
These two midfielders both possess attacking prowess and whoever has the better game could make a huge difference to the result.
Totti is a match-winning playmaker and Italy will be hoping he shows the form and pedigree which has so far deserted him in this World Cup.
Yoo gave notice of his desire to join the attack in his side's first game when he scored South Korea's second against Poland.
Like most of the co-hosts players, Yoo does not lack for energy and, along with his defensive duties, he is not scared to shoot from in and around the area.
Ahn Jung-Hwan v Alessandro Nesta