Computer users who want to donate as they use the web can now use a special NSPCC website that gives cash for every search they carry out.
The NSPCC has fought to protect children for years
The NSPCC, which campaigns to end child cruelty, will receive a donation every time users carry out an MSN search via www.clickscount.co.uk.
The charity hopes the site will raise substantial funds, and organisers hope to add other charities later this year.
The Clickscount campaign will run throughout the summer.
Elaine Dodds, NSPCC Head of Corporate Fundraising, said the idea was in a grand tradition of simple fundraising ideas.
"Every day, millions of searches are carried out across the UK. Now, thanks to MSN, each search can also raise money for children who are in desperate need of help."
Microsoft has used its MSN search portal to challenge the dominance of search giants Google and Yahoo among web users.
The company has a longstanding relationship with the NSPCC, donating some £5m and another £11m through fundraising in recent years.