Coronation Street overshadowed rival EastEnders by seven awards to one at the British Soap Awards ceremony.
Corrie's prizes included best soap, best actress for Kate Ford (Tracy Barlow) and best actor for Antony Cotton (Sean Tully).
Lacey Turner collected EastEnders' lone honour for best dramatic performance for her role as Stacey Slater.
Hollyoaks won three awards, and there were two each for Emmerdale and daytime drama Doctors.
Coronation Street also won sexiest male for Rob James-Collier (Liam Connor), best newcomer for Kym Ryder (Michelle Connor), and best exit for Bill Ward (Charlie Stubbs).
The ITV1 soap took the best storyline prize for the plot which saw Tracy take murderous revenge on cheating Charlie.
A spokeswoman for the long-running show said the cast were all "thrilled to bits".
"The quality of the writing and the acting is second to none, and it's just been our year."
Roxanne McKee from Hollyoaks was named sexiest female
Emmerdale won best dramatic performance from a young actor or actress for Eden Taylor-Draper (Belle Dingle), and spectacular scene of the year for the house collapse.
Hollyoaks' winners were sexiest female for Roxanne McKee (Louise Summers), villain of the year for Gemma Bissix (Clare Cunningham) and best comedy performance for Gemma Merna (Carmel McQueen).
Doctors celebrated awards for best on-screen partnership for Stirling Gallacher and Sean Gleeson (George and Ronnie Woodson) and best single episode for Shreds and Aftermath.
Former EastEnder Wendy Richard, who played Pauline Fowler, picked up the Lifetime Achievement Award.
It was presented by her on-screen son Todd Carty, who described her as the heart and soul of the programme.
The awards, voted for by a mix of viewers and judges, were held at BBC Television Centre in west London.
They will be screened on Wednesday 30 May at 2000 BST on ITV1, in a programme hosted by This Morning presenters Fern Britton and Phillip Schofield.