Fourth one-day international, Rawalpindi: Pakistan 210 (47.2 overs) bt England 197 all out (48.1 overs) by 13 runs
Pakistan beat England by 13 runs in Rawalpindi to take an unassailable 3-1 lead in the one-day series.
Kabir Ali and James Anderson put on 33 for the final wicket but Anderson was caught in the slips at full-stretch by Younis Khan with 11 balls left.
England looked favourites after dismissing Pakistan for 210, captain Inzamam-ul-Haq hitting 81 not out.
But, with the exception of Andrew Flintoff and Ian Blackwell, England's top order was again rooted out cheaply.
The final game of the tour is at the same venue on Wednesday.
With pace spearhead Steve Harmison ruled out, the portents were not good when Marcus Trescothick lost the toss for the first time in four games.
But super-sub James Anderson and Flintoff subdued Pakistan's openers with disciplined line and length and late swing.
Salman Butt was the first to fall, run out superbly by the diving Vikram Solanki in the covers off a Flintoff no-ball.
Flintoff bowled Younis Khan with his next delivery, the batsman playing on, before Anderson bowled Kamran Akmal through the gate with an off-cutter.
Ali - making his first England appearance since February - then trapped Mohammad Yousuf plumb lbw, leaving Inzamam to steady the innings.
The 35-year-old used all his experience to milk the England bowling and cracked Blackwell over the long-on boundary en route to his 82nd one-day fifty.
Shoaib Malik played a good foil in a partnership of 60 until he swept a Blackwell full-toss straight to Andrew Strauss at backward square-leg.
It was tough-going for Pakistan and even Shaid Afridi was sedate by his standards - apart from two mighty sixes off Paul Collingwood.
But just as he threatened to launch a final assault, he missed with a big heave and was bowled by Liam Plunkett, who produced a superb inswinging yorker to remove Abdul Razzaq next ball.
Rana Naved smashed two fours and a maximum off Ali before guiding a slower one to Collingwood at backward point.
And local hero Shoaib Akhtar did not last long, falling in almost identical fashion to Flintoff, while Mohammad Sami also failed to trouble the scorers before edging Anderson behind.
Inzamam was left stranded with almost three overs left in the innings, leaving England with an eminently gettable target.
However, Naved had England reeling with two wickets in successive balls, Matt Prior chasing a wide one and edging behind and Strauss getting trapped lbw plumb in front for a duck.
Solanki did not last long either, dragging an Akhtar delivery on to his stumps to leave England tottering on 25-3.
Trescothick was lucky to survive when it appeared he had edged Naved to wicket-keeper Akmal, but the England skipper did not last much longer.
Super-sub Arshad Khan cleaned him up with a straight one following two deliveries that turned square.
Mohammad Sami then dismissed Collingwood, who skewed a drive to Malik at backward point, before Afridi trapped Flintoff lbw to leave England in dire straits at 99-6.
Geraint Jones was next man out, driving straight to Naved at cover point, and Plunkett followed soon after, trapped lbw by the lively Afridi.
Akhtar dropped a straight-forward caught-and-bowled off Ali before Blackwell was run out by substitute fielder Mohammad Asif after he had hauled England back into the match.
Blackwell, who put on 50 with Ali, would have made his ground had he run straight down the pitch but veered off to his left and was undone by a direct hit.
Last man Anderson came to the wicket with 47 still needed and he and Ali proceeded to nudge England towards the target.
But the Lancashire paceman was caught in the slips at full stretch by stand-in skipper Younis with only 11 balls remaining.