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Mediterranean Diet and Incidence of and Mortality From Coronary Heart Disease and Stroke in Women | Circulation
Mediterranean Diet and Incidence of and Mortality From Coronary Heart Disease and Stroke in Women \| Circulation

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Research Article

Originally Published 16 February 2009

Free Access

# Mediterranean Diet and Incidence of and Mortality From Coronary Heart Disease and Stroke in Women

[Teresa T.Fung, ScD](#con1), [Kathryn M.Rexrode, MD](#con2), [Christos S.Mantzoros, MD](#con3), [JoAnn E.Manson, MD, DrPH](#con4), [Walter C.Willett, MD, DrPH](#con5), and [Frank B.Hu, MD, PhD](#con6) [Author Info & Affiliations](#tab-contributors)

Circulation

[Volume 119, Number 8](/toc/circ/119/8)

[https://doi.org/10.1161/CIRCULATIONAHA.108.816736](https://doi.org/10.1161/CIRCULATIONAHA.108.816736)

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- Contents

- [Abstract](#abstract)
- [Methods](#sec-1)
- [Results](#sec-2)
- [Discussion](#sec-3)
- [Conclusion](#sec-4)
- [Acknowledgments](#acknowledgments)
- CLINICAL PERSPECTIVE
- [References](#bibliography)

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This article has been corrected.

[VIEW CORRECTION](/doi/10.1161/CIRCULATIONAHA.109.192220)

## Abstract

**_Background—_** Several studies have documented an inverse association between adherence to the Mediterranean diet and risk of coronary heart disease (CHD), but few data are available on the relationship between Mediterranean diet and risk of stroke.

**_Methods and Results—_** For the present study, 74 886 women 38 to 63 years of age in the Nurses’ Health Study, a cohort study of female nurses, without a history of cardiovascular disease and diabetes were followed up from 1984 to 2004. We computed an Alternate Mediterranean Diet Score from self-reported dietary data collected through validated food frequency questionnaires administered 6 times between 1984 and 2002. Relative risks for incident CHD, stroke, and combined fatal cardiovascular disease were estimated with Cox proportional-hazards models adjusted for cardiovascular risk factors. During 20 years of follow-up, 2391 incident cases of CHD, 1763 incident cases of stroke, and 1077 cardiovascular disease deaths (fatal CHD and strokes combined) were ascertained. Women in the top Alternate Mediterranean Diet Score quintile were at lower risk for both CHD and stroke compared with those in the bottom quintile (relative risk \[RR\], 0.71; 95% CI, 0.62 to 0.82; _P_ for trend<0.0001 for CHD; RR, 0.87; 95% CI, 0.73 to 1.02; _P_ for trend=0.03 for stroke). Cardiovascular disease mortality was significantly lower among women in the top quintile of the Alternate Mediterranean Diet Score (RR, 0.61; 95% CI, 0.49 to 0.76; _P_ for trend<0.0001).

**_Conclusion—_** A greater adherence to the Mediterranean diet, as reflected by a higher Alternate Mediterranean Diet Score, was associated with a lower risk of incident CHD and stroke in women.

The traditional Mediterranean diet is characterized by a high intake of monounsaturated fat, plant proteins, whole grains, and fish; moderate intake of alcohol; and low consumption of red meat, refined grains, and sweets. [1](#R1-191995) An intervention trial has recently shown that the Mediterranean diet is more effective in promoting weight loss and lowering the ratio of total to high-density lipoprotein cholesterol in obese individuals than a low-fat diet. [2](#R2-191995) Previously, the Lyon Heart Study showed that the Mediterranean diet was more effective than a low-fat diet in the secondary prevention of cardiac events. [3,4](#R3-191995) Since then, the Mediterranean diet pattern has been shown in several prospective studies from around the world to be inversely associated with total and cardiovascular (CVD) mortality. [5,6](#R5-191995) However, data are limited for its relationship with nonfatal cardiovascular events. To the best of our knowledge, no studies have specifically focused on the incidence of stroke or stroke mortality. In addition, in investigating the association between diet and disease with a slow progression such as coronary heart disease (CHD) and stroke, the availability of multiple dietary measurements over time provides a better estimate of overall diet over the follow-up period.

> Clinical Perspective p 1100

We have previously constructed a Mediterranean diet adherence score for the Nurses’ Health Study (NHS) [7](#R7-191995) based on a prior scoring system developed for Greek populations. [8](#R8-191995) This Alternate Mediterranean Diet Score (aMed) focuses on higher consumption of plant foods, including plant proteins, monounsaturated fat, and fish and lower consumption of animal products and saturated fat. In the present analysis, we used data from multiple dietary assessments to prospectively examine the association between the aMed and risk of incident CHD and stroke, as well as CVD mortality, in women. We also combined nonfatal and fatal CHD and stroke incidence to assess the association of aMed with major CVD events.

## Methods

### Study Population

The NHS is a cohort study of 121 700 female nurses 30 to 55 years of age living in 11 US states at the time of inception (1976). The first questionnaire regarding medical, lifestyle, and other health-related information was sent at that time. [9](#R9-191995) Since then, questionnaires have been sent biennially to update this information. Follow-up was complete for >95% of the potential person-time up to 2004. In 1980, the participants completed a 61-item food frequency questionnaire (FFQ). In 1984, the FFQ was expanded to 116 items. Similar FFQs were sent in 1986, 1990, 1994, 1998, and 2002.

For this analysis, we included women who completed the 1984 FFQ with <70 missing items and total energy intake (as calculated from the FFQ) between 500 and 3500 kcal/d. [10](#R10-191995) At baseline, we excluded those with a history of CHD, stroke, or diabetes because diagnoses of these conditions may lead to changes in diet. Thus, 76 522 women with follow-up from 1984 through 2004 were included in the analyses. This study was approved by the Institutional Review Board of the Brigham and Women’s Hospital, Boston, Mass.

### Dietary Assessment

Self-reported FFQs were designed to assess average food intake over the preceding year. A standard portion size and 9 possible frequency of consumption responses, ranging from “never or less than once per month” to “≥6 times per day” were given for each food. Total energy and nutrient intake was calculated by summing energy or nutrients from all foods. Previous validation studies in this cohort revealed good correlations between nutrients assessed by the FFQ and multiple weeks of food records completed over the preceding year. [10](#R10-191995) For example, correlation coefficients between the 1986 FFQ and 4 weeks of diet records obtained in 1986 were 0.68 for saturated fat and 0.78 for crude fiber. The mean correlation coefficient between frequencies of intake of 55 foods assessed by 2 FFQ 12 months apart was 0.57. [10,11](#R10-191995)

The aMed score was adapted from the Mediterranean diet scale by Trichopoulou et al. [8](#R8-191995) Our components include vegetables (excluding potatoes), fruits, nuts, whole grains, legumes, fish, ratio of monounsaturated to saturated fat, red and processed meats, and alcohol. Participants with intake above the median intake received 1 point for these categories; otherwise, they received 0 points. Red and processed meat consumption below the median received 1 point. We assigned 1 point for alcohol intake between 5 and 15 g/d. This represents approximately one 12-oz can of regular beer, 5 oz of wine, or 1.5 oz of liquor. The possible score range for aMed was 0 to 9, with a higher score representing closer resemblance to the Mediterranean diet. [Table 1](#TBL1191995) shows the intake of aMed components during the follow-up periods. Consumption of each food group was stable across time except for a trend toward a decrease in alcohol and red/processed meat intake.

Table 1. Participant Characteristics and Median (Interquartile Range) Intake of aMed Components for the Years in Which FFQ Was Administered

198419861990199419982002Values are expressed as servings per day unless stated otherwise.\*Potatoes and French fries were not included.Mean aMed score3.94.04.04.54.44.3Alcohol, g/d2.0 (0–9.5)1.8 (0–7.8)1.1 (0–6.0)1.1 (0–6.1)1.0 (0–6.3)1.2 (0–7.8)Red/processed meat0.9 (0.6–1.3)0.8 (0.5–1.1)0.6 (0.4–1.0)0.6 (0.4–0.9)0.6 (0.3–0.9)0.5 (0.2–0.9)Fish0.2 (0.1–0.4)0.3 (0.1–0.4)0.3 (0.1–0.5)0.2 (0.1–0.4)0.2 (0.1–0.3)0.2 (0.1–0.3)Whole grains0.6 (0.2–1.1)1.1 (0.6–1.8)1.1 (0.5–1.8)1.0 (0.5–1.7)1.0 (0.5–1.6)1.0 (0.4–1.7)Legumes0.3 (0.2–0.6)0.3 (0.2–0.6)0.3 (0.2–0.6)0.3 (0.2–0.6)0.3 (0.2–0.5)0.3 (0.1–0.5)Nuts0.1 (0–0.4)0.2 (0.1–0.4)0.1 (0–0.4)0.1 (0–0.4)0.1 (0–0.4)0.2 (0.1–0.6)Fruits1.9 (1.2–2.8)2.3 (1.4–3.3)2.1 (1.3–3.1)2.2 (1.4–3.1)2.2 (1.4–3.2)1.9 (1.1–2.9)Vegetables\*2.6 (1.8–3.8)3.1 (2.1–4.4)2.7 (1.8–3.8)2.9 (2.0–4.1)2.7 (1.8–3.9)2.5 (1.5–3.7)Monounsaturated to saturated fat ratio1.0 (0.9–1.1)1.0 (0.9–1.1)1.1 (1.0–1.2)1.1 (1.0–1.3)1.1 (1.0–1.3)1.1 (1.0–1.3)

### End-Point Ascertainment

For these analyses, we ascertained incident cases of CHD (nonfatal myocardial infarct \[MI\] or fatal CHD) and stroke that occurred after the return of the 1984 questionnaire but before June 1, 2004. We requested permission to review medical records from women who reported having a nonfatal MI or stroke on each biennial questionnaire. Physicians unaware of the self-reported risk factor status reviewed the records. For each case, the year and month of diagnosis were recorded as the diagnosis date. For MI, we noted whether it was fatal or nonfatal. MI was classified as confirmed if the criteria of the World Health Organization were met, specifically, symptoms and either echocardiogram changes or elevated cardiac enzyme levels. [12](#R12-191995) If medical records were not available, the case was considered probable. We included confirmed and probable cases for the analyses. Fatal CHD events were confirmed by hospital records, by autopsy, or by CHD listed as the cause of death on the death certificate, if it was listed as an underlying and the most plausible cause of death, and if evidence of previous CHD was available.

Strokes were confirmed by medical record review using National Survey of Stroke criteria, [13](#R13-191995) which require a constellation of neurological deficits, sudden or rapid in onset with a duration of at least 24 hours or until death. We classified strokes as ischemic (embolic or thrombotic), hemorrhagic (subarachnoid or intracerebral), or undetermined according to medical record evidence and computed tomography, magnetic resonance imaging, or autopsy findings. Deaths were identified from state vital statistics records and the National Death Index or reported by the families and the postal system. Strokes for which medical records were not available were considered probable. In our cohort, ≈17% of all strokes and 24% of MIs were classified as probable. Confirmed and probable cases were combined in our analyses.

### Assessment of Covariates

Body mass index (BMI) was calculated from weight reported on each biennial questionnaire and height reported in 1976. In each biennial questionnaire, we also assessed smoking status (including number of cigarettes), frequency and number of aspirin tablets used, multivitamin intake, and menopausal status and use of postmenopausal hormone. Leisure-time physical activity was measured biennially beginning in 1986 with a validated questionnaire asking about average time spent on 10 common activities. The information was then summed and calculated as metabolic equivalent hours. [14](#R14-191995)

### Statistical Analysis

We used Cox proportional-hazard modeling to assess the association between the aMed score and risk of CHD and stroke, including separate models for fatal and nonfatal CHD and ischemic and hemorrhagic stroke because the cause of subtypes may differ. We combined all CHD and stroke cases as total major CVDs and fatal CHD and fatal stroke as fatal major CVDs. For individuals with confirmed diagnoses of stroke and CHD on the same year and month, we included both end points in the CHD or stroke analyses. However, these individuals contributed to only 1 end point in the total major CVD analysis.

To reduce random within-person variation and to best represent long-term dietary intake, we calculated cumulative averages of the aMed score from our repeated FFQs. [15](#R15-191995) For example, the aMed score in 1984 was used to predict CHD and stroke occurrence from 1984 to 1986, and the average score from 1984 and 1986 was used to predict CHD and stroke risk from 1986 to 1990, and so forth. An overall risk ratio for the entire follow-up period was then computed with the Cox proportional-hazards model. We adjusted for the following potential confounders, which were updated at each 2-year cycle: age (continuous), smoking (never, past, or current with cigarette use of 1 to 14, 15 to 24, ≥25 per day or missing), BMI (<22, 22.1 to 23.0, 23.1 to 24.9, 25.0 to 29.9, ≥30 kg/m2), menopausal status and postmenopausal hormone use (premenopausal, never, past, current hormone use), energy intake (quintiles), multivitamin intake (yes/no), alcohol intake (0, up to 5, 5 to 15, >15 g/d), family history (yes/no), physical activity (quintiles), and aspirin use (<1, 1 to 2, 3 to 6, 7 to 14, ≥15 per week). Statistical analysis was conducted with SAS version 9 (SAS Institute, Inc, Cary, NC).

In secondary analyses, we additionally adjusted for use of cholesterol-lowering and antihypertensive medications, history of hypertension, hypercholesterolemia, and diabetes diagnosed during follow-up. We also stratified by major risk factors at baseline to evaluate potential interactions between these factors and the aMed in relation to CHD and stroke risk. In addition, we assessed the association between changes in aMed score between 1984 and 1990 and risk of CHD and stroke from 1990 to 2004.

The authors had full access to and take responsibility for the integrity of the data. All authors have read and agree to the manuscript as written.

## Results

During up to 20 years of follow-up, we ascertained 2391 cases of CHD, of which 1597 were nonfatal and 794 were fatal. We also ascertained 1763 cases of stroke, of which 959 cases were ischemic, 329 cases were hemorrhagic, and 475 cases could not be clearly classified. Of all strokes, 1480 cases were nonfatal and 283 cases were fatal. At baseline, women with higher aMed score tended to exercise more and were less likely to be smokers ( [Table 2](#TBL2191995)). They also consumed more calories and fiber but less saturated fat.

Table 2. Age Standardized Baseline Characteristics According to Quintiles of 1984 aMed Scores

aMedQ1Q2Q3Q4Q5\*All values energy-adjusted except for energy.†Servings per day unless otherwise stated.Participant characteristics    BMI24.924.924.924.924.6    Current smokers, %3026232016    Leisure time physical activity, MET/wk1112141619    History of hypertension, %78788    History of hypercholesterolemia, %23334    Family history of CHD1919181920Dietary intake\*    Energy, kcal15461644173818491986    Glycemic load98999999102    Carbohydrates, g179183185187194    Protein, g6870727375    Monounsaturated fat, g2423232221    Saturated fat, g2523222119    Trans fat, g44333    Long chain omega-3 fatty acids, g0.130.170.210.240.30    Dietary fiber, g1315161820Components of aMed score†    Alcohol, g6.86.97.17.07.2    Monounsaturated to saturated fat ratio0.971.021.031.041.08    Fish0.20.20.30.40.5    Red/processed meat1.01.00.90.90.8    Whole grains0.40.70.91.11.6    Legumes0.20.30.40.50.6    Fruit1.31.72.12.63.2    Vegetables1.82.43.03.64.4    Nuts0.10.30.30.40.5

After adjusting for potential confounders, we observed a significant inverse association between aMed and risk of CHD. Women in the top quintile of aMed score had a relative risk (RR) of 0.71 (95% CI, 0.62 to 0.82; _P_ for trend<0.0001) compared with those in the bottom quintile ( [Table 3](#TBL3191995)). The association appears somewhat stronger for fatal CHD, with an RR of 0.58 (95% CI, 0.45 to 0.75; _P_ for trend<0.0001) comparing the extreme quintiles.

Table 3. Relative Risks of CHD by Quintiles of aMED Score

Q1Q2Q3Q4Q5_P_ Trend\*Adjusted for age (continuous), smoking (never, past, current with cigarette use of 1–14 per day, 15–24 per day, ≥25 per day, and missing), BMI (<22, 22.1–23.0, 23.1–24.9, 25.0–29.9, and ≥30), menopausal status and postmenopausal hormone use (premenopausal, never, past, and current hormone use), energy intake (quintiles), multivitamin intake (yes/no), alcohol intake (0g per day, up to 5 g per day, 5—15 g per day, >15g per day), family history (yes/no), physical activity (quintiles), and aspirin use (<1 time per week, 1–2 times per week, 3–6 times per week, 7–14 times per week, ≥15 times per week).Average mean score (range)1.8 (0–2.5)3.1 (2.5–3.4)4.0 (3.5–4.4)4.9 (4.5–5.4)6.3 (5.5–9.0)Total CHD    Cases528518466474405    Person-years271 209285 181276 345274 812293 382    Age and energy adjusted10.81 (0.72–0.92)0.71 (0.63–0.81)0.66 (0.58–0.75)0.50 (0.43–0.57)<0.0001    Multivariate adjusted\*10.92 (0.82–1.04)0.87 (0.77–0.99)0.87 (0.76–0.99)0.71 (0.62–0.82)<0.0001Nonfatal CHD    Cases335333317318294    Age and energy adjusted10.83 (0.71–0.97)0.78 (0.67–0.91)0.72 (0.61–0.84)0.59 (0.50–0.70)<0.0001    Multivariate adjusted\*10.91 (0.78–1.07)0.90 (0.77–1.06)0.88 (0.75–1.04)0.78 (0.66–0.93)0.0008Fatal CHD    Cases193185149156111    Age and energy adjusted10.78 (0.64–0.96)0.60 (0.48–0.75)0.57 (0.46–0.71)0.35 (0.27–0.45)<0.0001    Multivariate adjusted\*10.94 (0.77–1.15)0.81 (0.65–1.00)0.85 (0.68–1.07)0.58 (0.45–0.75)<0.0001

For stroke, a significant inverse association also was observed when the top and bottom quintiles were compared, with an RR of 0.87 (95% CI, 0.73 to 1.02; _P_ for trend=0.03; [Table 4](#TBL4191995)). A similar magnitude of risk reduction was noted for ischemic and hemorrhagic strokes, although statistical significance was not reached, likely because of the reduced power in the subtype analysis. The association with aMed appeared to be stronger for fatal strokes (RR for extreme quintiles, 0.69; 95% CI, 0.44 to 1.07; _P_ for trend=0.10) and nonfatal strokes (RR, 0.90; 95% CI, 0.75 to 1.08; _P_ for trend=0.12). Results remained essentially unchanged after additional adjustment for use of cholesterol-lowering and antihypertensive medications and history of hypercholesterolemia, hypertension, and diabetes that occurred during follow-up for both CHD and stroke.

Table 4. Relative Risks of Stroke by Quintiles of aMED

Q1Q2Q3Q4Q5_P_ Trend\*Adjusted for the same variables as in [Table 2](#TBL2191995).†Strokes that could not be clearly classified as ischemic or hemorrhagic were included in the analysis of total stroke but not in ischemic or hemorrhagic strokes.Total stroke    Cases341380370341331    Person-years271 209285 181276 345274 812293 382    Age and energy adjusted10.91 (0.79–1.06)0.88 (0.76–1.03)0.75 (0.64–0.88)0.65 (0.55–0.77)<0.0001    Multivariate adjusted\*11.00 (0.86–1.16)1.03 (0.89–1.20)0.92 (0.79–1.08)0.87 (0.73–1.02)0.03Ischemic†    Cases163210209188189    Age and energy adjusted11.04 (0.85–1.28)1.01 (0.82–1.25)0.84 (0.67–1.04)0.74 (0.59–0.92)0.0004    Multivariate adjusted\*11.12 (0.91–1.40)1.13 (0.91–1.40)0.98 (0.79–1.23)0.94 (0.74–1.18)0.24Hemorrhagic†    Cases7174715657    Age and energy adjusted10.89 (0.64–1.24)0.87 (0.62–1.22)0.64 (0.45–0.92)0.60 (0.41–0.87)0.002    Multivariate adjusted\*10.99 (0.71–1.37)1.01 (0.72–1.42)0.77 (0.55–1.15)0.79 (0.54–1.16)0.17Nonfatal    Cases283317305282293    Age and energy adjusted10.92 (0.78–1.08)0.88 (0.74–1.03)0.75 (0.63–0.89)0.69 (0.58–0.82)<0.0001    Multivariate adjusted\*11.00 (0.85–1.17)1.00 (0.85–1.19)0.90 (0.75–1.07)0.90 (0.75–1.08)0.12Fatal    Cases5863655938    Age and energy adjusted10.88 (0.62–1.27)0.91 (0.64–1.31)0.77 (0.53–1.12)0.46 (0.30–0.71)0.0001    Multivariate adjusted\*11.04 (0.72–1.49)1.17 (0.81–1.68)1.07 (0.73–1.58)0.69 (0.44–1.07)0.10

In stratified analyses, we observed consistent results according to all covariates except for BMI ( [Tables 5 and 6](#TBL5191995)). The inverse association between aMed and CHD was stronger among women with BMI <25 kg/m2 (RR, 0.57; 95% CI, 0.46 to 0.71; _P_ for trend<0.0001) than those with BMI ≥25 kg/m2 (RR, 0.84; 95% CI, 0.69 to 1.02; _P_ for trend=0.08; _P_ for interaction=0.005). However, such an interaction was not found for stroke.

Table 5. Multivariate RR (95% CI) of Total CHD by Quintiles of aMED Stratified by Selected Cardiovascular Risk Factors

Q1Q2Q3Q4Q5_P_ Trend_P_ Interaction\*Adjusted for the same variables as in [Table 2](#TBL2191995), except for the variable of stratification.BMI <25 (n=1054)10.89 (0.73–1.06)0.73 (0.60–0.89)0.74 (0.61–0.90)0.57 (0.46–0.71)<0.0001BMI ≥25 (n=1338)10.96 (0.81–1.14)0.99 (0.84–1.18)0.99 (0.83–1.19)0.84 (0.69–1.02)0.080.005Physical activity >median (n=880)10.97 (0.77–1.23)0.86 (0.67–1.09)0.92 (0.73–1.16)0.77 (0.60–0.98)0.006Physical activity ≤median (n=1511)10.90 (0.78–1.05)0.88 (0.76–1.03)0.83 (0.70–0.97)0.66 (0.55–0.80)<0.00010.56Nonsmokers (n=1921)10.88 (0.76–1.01)0.81 (0.70–0.94)0.80 (0.69–0.93)0.66 (0.56–0.77)<0.0001Current smokers (n=470)10.99 (0.76–1.28)0.97 (0.73–1.29)1.05 (0.78–1.42)0.81 (0.56–1.17)0.370.16No history of hypertension (n=2011)10.91 (0.80–1.04)0.84 (0.73–0.96)0.85 (0.74–0.98)0.70 (0.60–0.81)<0.0001History of hypertension (n=380)10.91 (0.64–1.29)0.95 (0.66–1.35)0.95 (0.66–1.35)0.83 (0.57–1.22)0.630.14No history of hypercholesterolemia (n=2235)10.95 (0.84–1.08)0.87 (0.76–0.99)0.87 (0.76–1.00)0.70 (0.60–0.81)<0.0001History of hypercholesterolemia (n=156)10.41 (0.21–0.80)0.67 (0.37–1.21)0.52 (0.28–1.97)0.58 (0.31–1.06)0.330.60Family history of CHD (n=1695)10.92 (0.80–1.07)0.89 (0.77–1.04)0.86 (0.73–1.00)0.71 (0.60–0.84)<0.0001No family history of CHD (n=696)10.98 (0.77–1.24)0.84 (0.65–1.07)0.94 (0.73–1.20)0.76 (0.58–0.99)0.030.89

Table 6. Multivariate RR of Total Stroke by Quintiles of aMED Stratified by Selected Cardiovascular Risk Factors

Q1Q2Q3Q4Q5_P_ Trend_P_ Interaction\*Adjusted for the same variables as in [Table 2](#TBL2191995), except for the variable of stratification.BMI <25 (n=838)11.06 (0.84–1.33)1.18 (0.94–1.48)0.97 (0.76–1.23)0.99 (0.77–1.26)0.48BMI ≥25 (n=925)10.94 (0.77–1.15)0.91 (0.74–1.12)0.87 (0.70–1.87)0.75 (0.60–0.95)0.020.12Physical activity >median (n=660)10.96 (0.72–1.27)1.14 (0.87–1.49)0.82 (0.61–1.08)0.80 (0.60–1.03)0.06Physical activity ≤median (n=1103)10.98 (0.82–1.17)0.92 (0.76–1.11)0.95 (0.78–1.15)0.86 (0.70–1.06)0.060.44Non mokers (n=1503)10.95 (0.80–1.12)0.98 (0.83–1.16)0.88 (0.74–1.04)0.85 (0.71–1.02)0.04Current smokers (n=260)11.10 (0.78–1.57)1.09 (0.74–1.59)1.06 (0.70–1.61)0.63 (0.36–1.11)0.170.96No history of hypertension (n=1509)10.98 (0.84–1.15)1.03 (0.87–1.21)0.92 (0.77–1.09)0.86 (0.72–1.03)0.05History of hypertension (n=254)11.16 (0.77–1.74)0.98 (0.64–1.50)0.95 (0.61–1.48)0.79 (0.50–1.26)0.210.55No history of hypercholesterolemia (n=1672)11.00 (0.86–1.16)1.03 (0.88–1.20)0.94 (0.80–1.11)0.86 (0.73–1.02)0.04History of hypercholesterolemia (n=91)10.99 (0.43–2.24)0.73 (0.31–1.70)0.66 (0.27–1.62)0.71 (0.30–1.68)0.310.63No family history of CHD (n=1356)11.04 (0.88–1.23)1.06 (0.89–1.26)0.93 (0.78–1.12)0.87 (0.20–1.05)0.05Family history of CHD (n=407)10.91 (0.66–1.25)0.97 (0.70–1.34)0.94 (0.67–1.31)0.86 (0.61–1.21)0.440.70

Women who remained in the highest quintiles (fourth or fifth quintile; 294 CHD cases) between 1984 and 1990 had an RR of 0.72 (95% CI, 0.61 to 0.84; _P_ <0.0001) for developing CHD during follow-up from 1990 to 2004 compared with those who remained in the lowest quintiles (first or second quintile; 410 cases). Risk for CHD for women who changed from low to high score (126 cases) or from high to low score (118 cases) was not significantly different from those who remained low.

When we evaluated total CVD (combined CHD and stroke incidence), we noted a 22% risk reduction comparing extreme quintiles of aMed score ( _P_ for trend<0.0001) after multivariate adjustment ( [Figure](#FIG1191995), A). Fatal CVD (fatal CHD and fatal stroke combined) risk also was lower among women in the top quintile of the aMed score (RR, 0.61; 95% CI, 0.49 to 0.76; _P_ for trend<0.0001) compared with those in the lowest quintile ( [Figure](#FIG1191995), B).

![](/cms/10.1161/CIRCULATIONAHA.108.816736/asset/d97b66f4-0a1f-4253-bb49-db4a04cfd3cf/assets/graphic/13ff1.jpeg)**Figure.** A, Multivariate (adjusted for the same variables as in [Table 2](#TBL2191995)) RR of CVD (combined CHD and stroke) by quintiles of aMed. ♦ Indicates incidence of CVD ( _P_ for trend<0.0001). B, Multivariate (adjusted for the same variables as in [Table 2](#TBL2191995)) RR of fatal CVD (combined CHD and stroke mortality) by quintiles of aMed. ♦ Indicates incidence of fatal CVD ( _P_ for trend<0.0001).

## Discussion

In the present large cohort of women with 20 years of follow-up, greater adherence to a Mediterranean dietary pattern, as measured by a higher aMed score, was significantly associated with lower risk of incident CHD and stroke. We also observed lower CVD mortality with higher aMed score.

Previous studies generally support an inverse association between adherence to the Mediterranean dietary pattern and risk of CHD. Among middle-aged American, a high aMed score (≥6) was associated with a 22% reduction in cardiovascular mortality in men and a 19% reduction in mortality in women compared with those with a low score (≤3). [6](#R6-191995) Elderly Europeans with no history of cardiovascular disease who adhered to the Mediterranean diet more closely had a lower risk of CHD mortality. [8](#R8-191995) However, we are unaware of any prior reports that specifically examined the association between Mediterranean diet and stroke incidence.

A Mediterranean dietary pattern shares components with several other healthy eating patterns that have previously been shown to reduce cardiovascular disease risk. The Alternate Healthy Eating Index, emphasizing plant foods and unsaturated oils, was shown to reduce CVD mortality in both men and women. [16](#R16-191995) In addition, the Dietary Approaches to Stop Hypertension diet pattern, which also emphasizes high intake of plant foods, low intake of animal protein, and low intake of sweets, [17](#R17-191995) was associated with lower risk of CHD and stroke in this cohort. [18](#R18-191995)

The Mediterranean diet has been linked to beneficial effects on inflammatory markers, lipids, and blood pressure. In cross-sectional analyses, adherence to the Mediterranean diet as measured by various indexes was associated with lower levels of C-reactive protein [19](#R19-191995) and interleukin-6 [20](#R20-191995) and markers of endothelial function. [19,21](#R19-191995) A 2-year randomized trial with a Mediterranean-style diet was effective in reducing C-reactive protein and interleukin-6 in individuals with metabolic syndrome. [22](#R22-191995) A higher Mediterranean diet score was associated with more favorable levels of adiponectin, [23](#R23-191995) an adipocytokine linked to CHD risk. [24](#R24-191995) In a Greek population without hypertension, a higher Mediterranean diet score was associated with lower systolic and diastolic blood pressures. [25](#R25-191995) In another 3-month randomized trial, the traditional Mediterranean diet was more effective in reducing oxidized low-density lipoprotein levels [26](#R26-191995) and blood pressure than a low-fat diet. [27](#R27-191995) In a 2-year randomized trial, the Mediterranean diet has resulted in significant weight loss and a more favorable ratio of total to high-density lipoprotein cholesterol and was more effective than a low-fat diet. [2](#R2-191995)

The association between Mediterranean dietary pattern appeared even stronger for fatal than nonfatal CHD. Fatal CHD events are generally characterized by either more severe disease or arrhythmia. This may reflect that higher fish intake, an important component of the aMed, has been strongly associated with lower risk of CHD deaths. [28,29](#R28-191995) A stronger association with fatal CVD events is consistent with the idea that the Mediterranean dietary pattern not only is beneficial for prevention of nonfatal CVD events but also can improve survival among patients with existing CVD. [3,4](#R3-191995)

The aMed is based on the literature and our a priori hypotheses. A score always involves some level of arbitrary decision in the type and number of foods to be included and assignment of points to different levels of intake. Although our score is largely similar to those reported in the literature in the choice of food groups, there are some differences. The score used by Pitsavos et al [30](#R30-191995) and that developed by Trichopoulou et al [8](#R8-191995) awarded points for potato intake, but ours did not. The Trichopoulou et al score included a dairy component; the aMed did not. In addition, several dietary factors that have been demonstrated to be important for CHD risk such as _trans_ fat, [31](#R31-191995) n-6 polyunsaturated fatty acids, [32](#R32-191995) and glycemic load [33,34](#R33-191995) were not included in any of the Mediterranean diet scores. However, the omitted dietary components are likely to be associated with foods that are included in the score; thus, the score does account for them to a certain extent. For example, in our cohort, women with high aMed score appeared to have lower _trans_ fat intake.

Another difference between scoring systems is the assignment of points. The score used by Pitsavos et al [30](#R30-191995) classified adherence by assigning 0 to 5 points for each food component, whereas the scoring by Trichopoulou et al [8](#R8-191995) and aMed used dichotomous points. However, results from different studies generally showed more favorable health outcomes in individuals with a higher Mediterranean diet score regardless of the scoring criteria. The aMed score assignment depends on intake relative to the level in the population. Therefore, when the scoring algorithm is applied to different populations, individuals from these populations may have the same score, but actual intake of each component could vary substantially.

The major sources of monounsaturated fat differ between the United States and other countries, especially Mediterranean countries, and by time period. In the first half of the follow-up period, the major sources (>30%) of monounsaturated fat in our cohort were beef and other meats. In the second half of follow-up, the contribution of beef and other meats dropped to ≈18%. At the same time, olive oil consumption increased considerably, but it still contributed only ≈10% of all monounsaturated fat intake. In contrast, in traditional Mediterranean diets of the 1960s, olive oil, along with other plant foods, is the primary source of monounsaturated fat intake. [1](#R1-191995)

The long follow-up period in this study allowed us to assess long-term associations between the aMed score and CVD. The prospective assessment of diet and lifestyle information in this analysis reduces the probability of recall bias. A high rate of follow-up reduced potential selection bias caused by systematic loss to follow-up. We used repeated measurements of diet to obtain a better assessment of long-term overall diet and to reduce measurement error, and CVD ascertainment was not influenced by risk factor or dietary intake of the cases. Confounding is always a concern in observational studies, and some level of residual confounding is unavoidable. Given our detailed and updated adjustment for potential confounders, it is unlikely that this would account for the observed results. Because this analysis is conducted in women and because it is the first report on the effects of Mediterranean diet on stroke, our results need to be replicated in other populations, especially men.

## Conclusion

A greater adherence to the Mediterranean diet, as reflected by a higher aMed score, was associated with a lower risk of incident CHD and stroke in women.

## Acknowledgments

**Sources of Funding**

This work was supported by National Institutes of Health grants CA87969, HL60712, HL34594, and HL88521.

**Disclosures**

None.

## CLINICAL PERSPECTIVE

This article has been corrected.

[VIEW CORRECTION](/doi/10.1161/CIRCULATIONAHA.109.192220)

The present study examined the association between the Alternate Mediterranean Diet Score (aMed) and risk of CHD and stroke in the Nurses’ Health Study. A higher score represents higher intake of vegetables (excluding potatoes), fruits, nuts, whole grains, legumes, fish, and ratio of monounsaturated to saturated fat; lower intake of red and processed meats; and alcohol intake between 5 and 15 g/d. Although a number of studies on various scores have measured adherence to the Mediterranean diet, most of them focused on total or CHD mortality, and none examined stroke as a separate outcome. This study differs by examining the incidence of CHD and stroke, which includes both fatal and nonfatal events. After adjustment for known risk factors for cardiovascular disease and energy intake, women in the highest 20% of the Alternate Mediterranean Diet Score had a lower risk for both CHD and stroke. Therefore, greater adherence to the Mediterranean diet, as reflected by a higher Alternate Mediterranean Diet Score, was associated with a lower risk of incident CHD and stroke in women.

### Footnote

Guest Editor for this article was Larry B. Goldstein, MD.

## References

1.

Willett WC, Sacks F, Trichopoulou A, Drescher G, Ferro-Luzzi A, Helsing E, Trichopoulos D. Mediterranean diet pyramid: a cultural model for healthy eating. _Am J Clin Nutr_ _._ 1995; _61_: 1402s–1406s.

[Crossref](https://doi.org/10.1093/ajcn/61.6.1402S)

[PubMed](https://pubmed.ncbi.nlm.nih.gov/7754995/)

[Google Scholar](https://scholar.google.com/scholar_lookup?title=Am+J+Clin+Nutr&publication_year=1995&pages=1402s&doi=10.1093%2Fajcn%2F61.6.1402S&pmid=7754995)

2.

Shai I, Schwarzfuchs D, Henkin Y, Shahar DR, Witkow S, Greenberg I, Golan R, Fraser D, Bolotin A, Vardi H, Tangi-Rozental O, Zuk-Ramot R, Sarusi B, Brickner D, Schwartz Z, Sheiner E, Marko R, Katorza E, Thiery J, Fiedler GM, Bluher M, Stumvoll M, Stampfer MJ, for the Dietary Intervention Randomized Controlled Trial (DIRECT) Group. Weight loss with a low-carbohydrate, Mediterranean, or low-fat diet. _N Engl J Med_ _._ 2008; _359_: 229–241.

[Crossref](https://doi.org/10.1056/NEJMoa0708681)

[PubMed](https://pubmed.ncbi.nlm.nih.gov/18635428/)

[Google Scholar](https://scholar.google.com/scholar_lookup?title=N+Engl+J+Med&publication_year=2008&pages=229&doi=10.1056%2FNEJMoa0708681&pmid=18635428)

3.

de Lorgeril M, Renaud S, Mamelle N, Salen P, Martin JL, Monjaud I, Guidollet J, Touboul P, Delaye J. Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease. _Lancet_ _._ 1994; _343_: 1454–1459.

[Crossref](https://doi.org/10.1016/S0140-6736(94)92580-1)

[PubMed](https://pubmed.ncbi.nlm.nih.gov/7911176/)

[Google Scholar](https://scholar.google.com/scholar_lookup?title=Lancet&publication_year=1994&pages=1454&doi=10.1016%2FS0140-6736%2894%2992580-1&pmid=7911176)

4.

De Lorgeril M, Salen P, Martin JL, Monjaud I, Delaye J, Mamelle N. Mediterranean diet, traditional risk factors and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study. _Circulation_ _._ 1999; _99_: 779–785.

[Crossref](https://doi.org/10.1161/circ.99.6.779)

[PubMed](https://pubmed.ncbi.nlm.nih.gov/9989963/)

[Google Scholar](https://scholar.google.com/scholar_lookup?title=Circulation&publication_year=1999&pages=779&doi=10.1161%2Fcirc.99.6.779&pmid=9989963)

5.

Knoops KT, de Groot LC, Kromhout D, Perrin AE, Moreiras-Varela O, Menotti A, van Staveren WA. Mediterranean diet, lifestyle factors, and 10-year mortality in elderly European men and women: the HALE project. _JAMA_ _._ 2004; _292_: 1433–1439.

[Crossref](https://doi.org/10.1001/jama.292.12.1433)

[PubMed](https://pubmed.ncbi.nlm.nih.gov/15383513/)

[Google Scholar](https://scholar.google.com/scholar_lookup?title=JAMA&publication_year=2004&pages=1433&doi=10.1001%2Fjama.292.12.1433&pmid=15383513)

6.

Mitrou PN, Kipnis V, Thiebaut Ac, Reedy J, Subar AF, Wirfalt E, Flood A, Mouw T, Hollenbeck AR, Letizmann M, Schatzkin A. Mediterranean dietary pattern and prediction of all-cause mortality in a U.S. population: results from the NIH-AARP Diet and Health Study. _Arch Intern Med_ _._ 2007; _167_: 2461–2468.

[Crossref](https://doi.org/10.1001/archinte.167.22.2461)

[PubMed](https://pubmed.ncbi.nlm.nih.gov/18071168/)

[Google Scholar](https://scholar.google.com/scholar_lookup?title=Arch+Intern+Med&publication_year=2007&pages=2461&doi=10.1001%2Farchinte.167.22.2461&pmid=18071168)

7.

Fung TT, McCullough ML, Newby PK, Manson JE, Meigs JB, Rifai N, Willett WC, Hu FB. Diet-quality scores and plasma concentrations of markers of inflammation and endothelial dysfunction. _Am J Clin Nutr_ _._ 2005; _82_: 163–173.

[Crossref](https://doi.org/10.1093/ajcn/82.1.163)

[PubMed](https://pubmed.ncbi.nlm.nih.gov/16002815/)

[Google Scholar](https://scholar.google.com/scholar_lookup?title=Am+J+Clin+Nutr&publication_year=2005&pages=163&doi=10.1093%2Fajcn%2F82.1.163&pmid=16002815)

8.

Trichopoulou A, Costacou T, Bamia C, Trichopoulos D. Adherence to a Mediterranean diet and survival in a Greek population. _N Engl J Med_ _._ 2003; _348_: 2599–2608.

[Crossref](https://doi.org/10.1056/NEJMoa025039)

[PubMed](https://pubmed.ncbi.nlm.nih.gov/12826634/)

[Google Scholar](https://scholar.google.com/scholar_lookup?title=N+Engl+J+Med&publication_year=2003&pages=2599&doi=10.1056%2FNEJMoa025039&pmid=12826634)

9.

Colditz GA, Martin P, Stampfer MJ, Willett WC, Sampson L, Rosner BA, Hennekens CH, Speizer FE. Validation of questionnaire information on risk factors and disease outcomes in a prospective cohort of women. _Am J Epidemiol_ _._ 1986; _123_: 894–900.

[Crossref](https://doi.org/10.1093/oxfordjournals.aje.a114319)

[PubMed](https://pubmed.ncbi.nlm.nih.gov/3962971/)

[Google Scholar](https://scholar.google.com/scholar_lookup?title=Am+J+Epidemiol&publication_year=1986&pages=894&doi=10.1093%2Foxfordjournals.aje.a114319&pmid=3962971)

10.

Willett WC. Nutritional Epidemiology. New York, NY: Oxford University Press; 1998.

[Google Scholar](https://scholar.google.com/scholar?q=Willett+WC.+Nutritional+Epidemiology.+New+York%2C+NY%3A+Oxford+University+Press%3B+1998.)

11.

Salvini SD, Hunter DJ, Sampson L, Stampfer MJ, Colditz GA, Rosner BA, Willett WC. Food-based validation of a dietary questionnaire: the effects of week-to-week variation in food consumption. _Int J Epidemiol_ _._ 1989; _18_: 858–867.

[Crossref](https://doi.org/10.1093/ije/18.4.858)

[PubMed](https://pubmed.ncbi.nlm.nih.gov/2621022/)

[Google Scholar](https://scholar.google.com/scholar_lookup?title=Int+J+Epidemiol&publication_year=1989&pages=858&doi=10.1093%2Fije%2F18.4.858&pmid=2621022)

12.

Rose GA, Blackburn H, Gillum R, Prineas R. Cardiovascular Survey Methods. Geneva, Switzerland: World Health Organization; 1982.

[Google Scholar](https://scholar.google.com/scholar?q=Rose+GA%2C+Blackburn+H%2C+Gillum+R%2C+Prineas+R.+Cardiovascular+Survey+Methods.+Geneva%2C+Switzerland%3A+World+Health+Organization%3B+1982.)

13.

Walker AE, Robins M, Weinfeld FD. The National Survey of Stroke: clinical findings. _Stroke_ _._ 1981; _12_ (pt 2 suppl 1): I-13–I-44.

[Google Scholar](https://scholar.google.com/scholar_lookup?title=Stroke&publication_year=1981&pages=I-13)

14.

Ainsworth BE, Haskell WL, Whitt MC, Irwin ML, Swartz AM, Strath SJ, O'Brien WL, Bassett DRJ, Schmitz KH, Emplaincourt PO, Jacobs DRJ, Leon AS. Compendium of physical activities: an update of activity codes and MET intensities. _Med Sci Sports Exerc_ _._ 2000; _32_ (suppl): S498–S504.

[Crossref](https://doi.org/10.1097/00005768-200009001-00009)

[PubMed](https://pubmed.ncbi.nlm.nih.gov/10993420/)

[Google Scholar](https://scholar.google.com/scholar_lookup?title=Med+Sci+Sports+Exerc&publication_year=2000&pages=S498&doi=10.1097%2F00005768-200009001-00009&pmid=10993420)

15.

Hu FB, Stampfer MJ, Rimm E, Ascherio A, Rosner BA, Spiegelman D, Willett WC. Dietary fat and coronary heart disease: a comparison of approaches for adjusting for total energy intake and modeling repeated dietary measurements. _Am J Epidemiol_ _._ 1999; _149_: 531–540.

[Crossref](https://doi.org/10.1093/oxfordjournals.aje.a009849)

[PubMed](https://pubmed.ncbi.nlm.nih.gov/10084242/)

[Google Scholar](https://scholar.google.com/scholar_lookup?title=Am+J+Epidemiol&publication_year=1999&pages=531&doi=10.1093%2Foxfordjournals.aje.a009849&pmid=10084242)

16.

McCullough ML, Feskanich D, Stampfer MJ, Giovannucci EL, Rimm EB, Hu FB, Spiegelman D, Colditz GA, Hunter DJ, Willett WC. Diet quality and major chronic disease risk in men and women: moving toward improved dietary guidance. _Am J Clin Nutr_ _._ 2002: 1261–1271.

[PubMed](https://pubmed.ncbi.nlm.nih.gov/12450892/)

[Google Scholar](https://scholar.google.com/scholar_lookup?title=Am+J+Clin+Nutr&publication_year=2002&pages=1261&pmid=12450892)

17.

Appel LJ, Moore TJ, Obarzanek E, Vollmer WM, Svetkey LP, Sacks FM, Bray GA, Vogt TM, Culter JA, Windhauser MM, Lin PH, Karanja N. A clinical trial of the effects of dietary patterns on blood pressure: DASH Collaborative Research Group. _N Engl J Med_ _._ 1997; _336_: 1117–1124.

[Crossref](https://doi.org/10.1056/NEJM199704173361601)

[PubMed](https://pubmed.ncbi.nlm.nih.gov/9099655/)

[Google Scholar](https://scholar.google.com/scholar_lookup?title=N+Engl+J+Med&publication_year=1997&pages=1117&doi=10.1056%2FNEJM199704173361601&pmid=9099655)

18.

Fung TT, Chiuve SE, McCullough ML, Rexrode KM, Logroscino G, Hu FB. Adherence to a DASH-style diet and risk of coronary heart disease and stroke in women. _Arch Intern Med_ _._ 2008; _168_: 713–720.

[Crossref](https://doi.org/10.1001/archinte.168.7.713)

[PubMed](https://pubmed.ncbi.nlm.nih.gov/18413553/)

[Google Scholar](https://scholar.google.com/scholar_lookup?title=Arch+Intern+Med&publication_year=2008&pages=713&doi=10.1001%2Farchinte.168.7.713&pmid=18413553)

19.

Fung TT, McCullough ML, Newby PK, Manson JE, Meigs JB, Rifai N, Willett WC, Hu FB. Diet-quality scores and plasma concentrations of markers of inflammation and endothelial dysfunction. _Am J Clin Nutr_ _._ 2005; _82_: 163–173.

[Crossref](https://doi.org/10.1093/ajcn/82.1.163)

[PubMed](https://pubmed.ncbi.nlm.nih.gov/16002815/)

[Google Scholar](https://scholar.google.com/scholar_lookup?title=Am+J+Clin+Nutr&publication_year=2005&pages=163&doi=10.1093%2Fajcn%2F82.1.163&pmid=16002815)

20.

Dai J, Miller AH, Bremner JD, Goldberg J, Jones L, Shallenberger L, Buckham R, Murrah NV, Veledar E, Wilson PW, Vaccarino V. Adherence to the Mediterranean diet is inversely associated with circulating interleukin-6 among middle-aged men: a twin study. _Circulation_ _._ 2008; _117_: 169–175.

[Crossref](https://doi.org/10.1161/CIRCULATIONAHA.107.710699)

[PubMed](https://pubmed.ncbi.nlm.nih.gov/18086924/)

[Google Scholar](https://scholar.google.com/scholar_lookup?title=Circulation&publication_year=2008&pages=169&doi=10.1161%2FCIRCULATIONAHA.107.710699&pmid=18086924)

21.

Serrano-Martinez M, Palacios M, Martinez-Losa E, Lezaun R, Maravi C, Prado M, Martinez JA, Martinez-Gonzalez MA. A Mediterranean dietary style influences TNF-alpha and VCAM-1 coronary blood levels in unstable angina patients. _Eur J Nutr_ _._ 2005; _44_: 348–354.

[Crossref](https://doi.org/10.1007/s00394-004-0532-9)

[PubMed](https://pubmed.ncbi.nlm.nih.gov/16151968/)

[Google Scholar](https://scholar.google.com/scholar_lookup?title=Eur+J+Nutr&publication_year=2005&pages=348&doi=10.1007%2Fs00394-004-0532-9&pmid=16151968)

22.

Esposito K, Marfella R, Ciotola M, Di Palo C, Giugliano F, Giugliano G, D'Armiento M, D'Andrea F, Giugliano D. Effect of a Mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial. _JAMA_ _._ 2004; _292_: 1440–1446.

[Crossref](https://doi.org/10.1001/jama.292.12.1440)

[PubMed](https://pubmed.ncbi.nlm.nih.gov/15383514/)

[Google Scholar](https://scholar.google.com/scholar_lookup?title=JAMA&publication_year=2004&pages=1440&doi=10.1001%2Fjama.292.12.1440&pmid=15383514)

23.

Mantzoros CS, Williams CJ, Manson JE, Meigs JB, Hu FB. Adherence to the Mediterranean dietary pattern is positively associated with plasma adiponectin concentrations in diabetic women. _Am J Clin Nutr_ _._ 2006; _84_: 328–335.

[Crossref](https://doi.org/10.1093/ajcn/84.2.328)

[PubMed](https://pubmed.ncbi.nlm.nih.gov/16895879/)

[Google Scholar](https://scholar.google.com/scholar_lookup?title=Am+J+Clin+Nutr&publication_year=2006&pages=328&doi=10.1093%2Fajcn%2F84.2.328&pmid=16895879)

24.

Pischon T, Girman CJ, Hotamisligil GS, Rifai N, Hu FB, Rimm E. Plasma adiponectin levels and risk of myocardial infarction in men. _JAMA_ _._ 2004; _291_: 1730–1737.

[Crossref](https://doi.org/10.1001/jama.291.14.1730)

[PubMed](https://pubmed.ncbi.nlm.nih.gov/15082700/)

[Google Scholar](https://scholar.google.com/scholar_lookup?title=JAMA&publication_year=2004&pages=1730&doi=10.1001%2Fjama.291.14.1730&pmid=15082700)

25.

Psaltopoulou T, Naska A, Orfanos P, Trichopoulos D, Mountokalakis T, Trichopoulou A. Olive oil, the Mediterranean diet, and arterial blood pressure: the Greek European Prospective Investigation Into Cancer and Nutrition (EPIC) study. _Am J Clin Nutr_ _._ 2004; _80_: 1012–1018.

[Crossref](https://doi.org/10.1093/ajcn/80.4.1012)

[PubMed](https://pubmed.ncbi.nlm.nih.gov/15447913/)

[Google Scholar](https://scholar.google.com/scholar_lookup?title=Am+J+Clin+Nutr&publication_year=2004&pages=1012&doi=10.1093%2Fajcn%2F80.4.1012&pmid=15447913)

26.

Fito M, Guzens M, Corella D, Saez G, Estruch R, de la Torre R, Frances F, Cabezas C, Lopez-Sabater Mdel C, Marrugat J, Garcia-Arellano A, Aros F, Ruiz-Gutierrez V, Ros E, Salas-Salvado J, Fiol M, Sola R, Covas MI, for the PREDIMED Study Investigators. Effect of a traditional Mediterranean diet on lipoprotein oxidation: a randomized controlled trial. _Arch Intern Med_ _._ 2007; _167_: 1195–1203.

[Crossref](https://doi.org/10.1001/archinte.167.11.1195)

[PubMed](https://pubmed.ncbi.nlm.nih.gov/17563030/)

[Google Scholar](https://scholar.google.com/scholar_lookup?title=Arch+Intern+Med&publication_year=2007&pages=1195&doi=10.1001%2Farchinte.167.11.1195&pmid=17563030)

27.

Estruch R, Martinez-Gonzalez MA, Corella D, Salas-Salvado J, Ruiz-Gutierrez V, Covas MI, Fiol M, Gomez-Gracia E, Lopez-Sabater MC, Vinyoles E, Aros F, Conde M, Lahoz C, Lapetra J, Saez G, Ros E, for the PREDIMED Study Investigators. Effects of a Mediterranean diet on cardiovascular risk factors: a randomized trial. _Ann Intern Med_ _._ 2006; _145_: 1–11.

[Crossref](https://doi.org/10.7326/0003-4819-145-1-200607040-00004)

[PubMed](https://pubmed.ncbi.nlm.nih.gov/16818923/)

[Google Scholar](https://scholar.google.com/scholar_lookup?title=Ann+Intern+Med&publication_year=2006&pages=1&doi=10.7326%2F0003-4819-145-1-200607040-00004&pmid=16818923)

28.

He K, Song Y, Daviglus ML, Liu K, van Horn L, Dyer AR, Greenland P. Accumulated evidence on fish consumption and coronary heart disease mortality: a meta-analysis of cohort studies. _Circulation_ _._ 2004; _109_: 2705–2711.

[Crossref](https://doi.org/10.1161/01.cir.0000132503.19410.6b)

[PubMed](https://pubmed.ncbi.nlm.nih.gov/15184295/)

[Google Scholar](https://scholar.google.com/scholar_lookup?title=Circulation&publication_year=2004&pages=2705&doi=10.1161%2F01.cir.0000132503.19410.6b&pmid=15184295)

29.

Mozaffarian D, Rimm E. Fish intake, contaminants, and human health: evaluating the risks and the benefits. _JAMA_ _._ 2006; _296_: 1885–1899.

[Crossref](https://doi.org/10.1001/jama.296.15.1885)

[PubMed](https://pubmed.ncbi.nlm.nih.gov/17047219/)

[Google Scholar](https://scholar.google.com/scholar_lookup?title=JAMA&publication_year=2006&pages=1885&doi=10.1001%2Fjama.296.15.1885&pmid=17047219)

30.

Pitsavos C, Panagiotakos DB, Tzima N, Chrysohoou C, Economou M, Zampelas A, Stefanadis C. Adherence to the Mediterranean diet is associated with total antioxidant capacity in healthy adults: the ATTICA study. _Am J Clin Nutr_ _._ 2005; _82_: 694–699.

[Crossref](https://doi.org/10.1093/ajcn/82.3.694)

[PubMed](https://pubmed.ncbi.nlm.nih.gov/16155285/)

[Google Scholar](https://scholar.google.com/scholar_lookup?title=Am+J+Clin+Nutr&publication_year=2005&pages=694&doi=10.1093%2Fajcn%2F82.3.694&pmid=16155285)

31.

Oh K, Hu FB, Manson JE, Stampfer MJ, Willett WC. Dietary fat intake and risk of coronary heart disease in women: 20 years of follow-up of the Nurses’ Health Study. _Am J Epidemiol_ _._ 2005; _161_: 672–679.

[Crossref](https://doi.org/10.1093/aje/kwi085)

[PubMed](https://pubmed.ncbi.nlm.nih.gov/15781956/)

[Google Scholar](https://scholar.google.com/scholar_lookup?title=Am+J+Epidemiol&publication_year=2005&pages=672&doi=10.1093%2Faje%2Fkwi085&pmid=15781956)

32.

Kuller LH. Nutrition, lipids, and cardiovascular disease. _Nutr Rev_ _._ 2006; _64_: S15–S26.

[Crossref](https://doi.org/10.1111/j.1753-4887.2006.tb00230.x)

[PubMed](https://pubmed.ncbi.nlm.nih.gov/16532896/)

[Google Scholar](https://scholar.google.com/scholar_lookup?title=Nutr+Rev&publication_year=2006&pages=S15&doi=10.1111%2Fj.1753-4887.2006.tb00230.x&pmid=16532896)

33.

Levitan EB, Mittleman MA, Hakansson N, Wolk A. Dietary glycemic index, dietary glycemic load, and cardiovascular disease in middle-aged and older Swedish men. _Am J Epidemiol_ _._ 2007; _85_: 1521–1526.

[Google Scholar](https://scholar.google.com/scholar_lookup?title=Am+J+Epidemiol&publication_year=2007&pages=1521)

34.

Liu S, Willett WC. Dietary glycemic load and atherothrombotic risk. _Curr Atheroscler Rep_ _._ 2002; _4_: 454–461.

[Crossref](https://doi.org/10.1007/s11883-002-0050-2)

[PubMed](https://pubmed.ncbi.nlm.nih.gov/12361493/)

[Google Scholar](https://scholar.google.com/scholar_lookup?title=Curr+Atheroscler+Rep&publication_year=2002&pages=454&doi=10.1007%2Fs11883-002-0050-2&pmid=12361493)

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Circulation

[Volume 119 • Number 8 • 3 March 2009](/toc/circ/119/8)

Pages: 1093 \- 1100

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#### Keywords

1. [coronary disease](/action/doSearch?AllField=coronary+disease&stemming=yes&publication=circ)
2. [diet](/action/doSearch?AllField=diet&stemming=yes&publication=circ)
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4. [stroke](/action/doSearch?AllField=stroke&stemming=yes&publication=circ)

#### Subjects

1. [Epidemiology](/topic/aha-collection/10062)

#### Notes

Received June 3, 2008; accepted November 17, 2008.

### Authors

#### Affiliations

Teresa T.Fung, ScD

From Simmons College (T.T.F.); Departments of Nutrition (T.T.F., W.C.W., F.B.H.) and Epidemiology (J.E.M., W.C.W., F.B.H.), Harvard School of Public Health; Channing Laboratory, Department of Medicine (W.C.W., F.B.H., J.E.M.) and Division of Preventive Medicine (K.M.R., J.E.M.), Brigham and Women’s Hospital and Harvard Medical School; and Department of Medicine, Harvard Medical School (C.S.M.), Boston, Mass.

[View all articles by this author](/authored-by/Fung/Teresa+T)

Kathryn M.Rexrode, MD

From Simmons College (T.T.F.); Departments of Nutrition (T.T.F., W.C.W., F.B.H.) and Epidemiology (J.E.M., W.C.W., F.B.H.), Harvard School of Public Health; Channing Laboratory, Department of Medicine (W.C.W., F.B.H., J.E.M.) and Division of Preventive Medicine (K.M.R., J.E.M.), Brigham and Women’s Hospital and Harvard Medical School; and Department of Medicine, Harvard Medical School (C.S.M.), Boston, Mass.

[View all articles by this author](/authored-by/Rexrode/Kathryn+M)

Christos S.Mantzoros, MD

From Simmons College (T.T.F.); Departments of Nutrition (T.T.F., W.C.W., F.B.H.) and Epidemiology (J.E.M., W.C.W., F.B.H.), Harvard School of Public Health; Channing Laboratory, Department of Medicine (W.C.W., F.B.H., J.E.M.) and Division of Preventive Medicine (K.M.R., J.E.M.), Brigham and Women’s Hospital and Harvard Medical School; and Department of Medicine, Harvard Medical School (C.S.M.), Boston, Mass.

[View all articles by this author](/authored-by/Mantzoros/Christos+S)

JoAnn E.Manson, MD, DrPH

From Simmons College (T.T.F.); Departments of Nutrition (T.T.F., W.C.W., F.B.H.) and Epidemiology (J.E.M., W.C.W., F.B.H.), Harvard School of Public Health; Channing Laboratory, Department of Medicine (W.C.W., F.B.H., J.E.M.) and Division of Preventive Medicine (K.M.R., J.E.M.), Brigham and Women’s Hospital and Harvard Medical School; and Department of Medicine, Harvard Medical School (C.S.M.), Boston, Mass.

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Walter C.Willett, MD, DrPH

From Simmons College (T.T.F.); Departments of Nutrition (T.T.F., W.C.W., F.B.H.) and Epidemiology (J.E.M., W.C.W., F.B.H.), Harvard School of Public Health; Channing Laboratory, Department of Medicine (W.C.W., F.B.H., J.E.M.) and Division of Preventive Medicine (K.M.R., J.E.M.), Brigham and Women’s Hospital and Harvard Medical School; and Department of Medicine, Harvard Medical School (C.S.M.), Boston, Mass.

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Frank B.Hu, MD, PhD

From Simmons College (T.T.F.); Departments of Nutrition (T.T.F., W.C.W., F.B.H.) and Epidemiology (J.E.M., W.C.W., F.B.H.), Harvard School of Public Health; Channing Laboratory, Department of Medicine (W.C.W., F.B.H., J.E.M.) and Division of Preventive Medicine (K.M.R., J.E.M.), Brigham and Women’s Hospital and Harvard Medical School; and Department of Medicine, Harvard Medical School (C.S.M.), Boston, Mass.

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#### Notes

Correspondence to Teresa Fung, Department of Nutrition, Simmons College, 300 The Fenway, Boston MA 02115. E-mail [\[email protected\]](/cdn-cgi/l/email-protection#2345564d4463504a4e4e4c4d500d464756)

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Fatty Acid Composition of Commercial Smoked Salmon Products, Turkish Journal of Maritime and Marine Sciences, **10**, 1, (39-48), (2024). [https://doi.org/10.52998/trjmms.1372161](https://doi.org/10.52998/trjmms.1372161 "Crossref")
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    - Mohamad Aman Jairajpuri,

Daily Considerations to Reduce the Risk of Cardiovascular Diseases, Causes and Management of Nutritional Deficiency Disorders, (293-339), (2024). [https://doi.org/10.4018/979-8-3693-2947-4.ch017](https://doi.org/10.4018/979-8-3693-2947-4.ch017 "Crossref")
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Exploring the Association between Mediterranean Diet Adherence and Arterial Stiffness in Healthy Adults: Findings from the EvasCu Study, Nutrients, **16**, 13, (2158), (2024). [https://doi.org/10.3390/nu16132158](https://doi.org/10.3390/nu16132158 "Crossref")
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