Depressão resistente: Outros tratamentos além dos antidepressivos
Como é possível tratar a depressão refratária? · Trocar a medicação antidepressiva · Combinar medicações · Potencializar a medicação · Uso de Inibidores de IMAO.
doenças crônicas
É possível também que o resultado seja comprometido por conta de <anchor>doenças crônicas</anchor>, distúrbios, uso de outros medicamentos e transtornos psicológicos já presentes. Então, se de forma solo ou combinada, o paciente não responder a esses estímulos, é necessário atuar com mais substâncias cerebrais, na qual devem ser identificadas e analisadas de modo certeiro.
Antidepressants not always effective in people with chronic disease - Harvard Health
Antidepressants not always effective in people with chronic disease - Harvard Health

[Harvard Health Publishing![Harvard Health Publishing Logo](https://www.health.harvard.edu/img/logos/NEW-HHP_logo_stack4.svg)](https://www.health.harvard.edu) [Harvard Health Publishing](https://www.health.harvard.edu)

Search

Search

Close

[Shopping Cart](https://www.health.harvard.edu/cart)

[Customer Service](https://www.health.harvard.edu/customer-service) [Content Licensing](https://www.health.harvard.edu/licensing) [About Us](https://www.health.harvard.edu/about-us) [Login](https://www.health.harvard.edu/login)

Open mobile menu

Menu

[Free HealthBeat Signup](https://www.health.harvard.edu/healthbeat)

Shop

[Subscriptions](https://www.health.harvard.edu/subscribe) [Special Health Reports](https://www.health.harvard.edu/special-health-reports) [Online Courses](https://www.harvardhealthonlinelearning.com)

[Pay Subscription Bill](https://www.health.harvard.edu/pay-bill)

[Common Conditions](https://www.health.harvard.edu/category/common-conditions) [Staying Healthy](https://www.health.harvard.edu/category/staying-healthy) [Resources](https://www.health.harvard.edu/resources) [Blog](https://www.health.harvard.edu/blog) [COVID-19 Updates](https://www.health.harvard.edu/diseases-and-conditions/coronavirus-resource-center)

Close menu

Close

## Main Content

- [Common Conditions](https://www.health.harvard.edu/category/common-conditions)
- [Staying Healthy](https://www.health.harvard.edu/category/staying-healthy)
- [Resources](https://www.health.harvard.edu/resources)
- [Blog](https://www.health.harvard.edu/blog)

## Helpful Links

- [Customer Service](https://www.health.harvard.edu/customer-service)
- [About Us](https://www.health.harvard.edu/about-us)
[Login](https://www.health.harvard.edu/login)- [Content Licensing](https://www.health.harvard.edu/licensing)

- [Free Healthbeat Signup](https://www.health.harvard.edu/healthbeat)
- [Subscriptions](https://www.health.harvard.edu/subscribe)
- [Special Health Reports](https://www.health.harvard.edu/special-health-reports)
- [Online Courses](https://www.harvardhealthonlinelearning.com)
- [Pay Subscription Bill](https://www.health.harvard.edu/pay-bill)

## Recent Blog Articles

[![blog image 1](https://domf5oio6qrcr.cloudfront.net/medialibrary/11789/conversions/27f3a0d2-6570-49be-9964-b1e8a4dd243e-micro.jpg)\
\
Boosting your child's immune system](https://www.health.harvard.edu/blog/boosting-your-childs-immune-system-202110122614) [![blog image 1](https://domf5oio6qrcr.cloudfront.net/medialibrary/15626/conversions/gettyimages-877738018-micro.jpg)\
\
Gratitude enhances health, brings happiness — and may even lengthen lives](https://www.health.harvard.edu/blog/gratitude-enhances-health-brings-happiness-and-may-even-lengthen-lives-202409113071) [![blog image 1](https://domf5oio6qrcr.cloudfront.net/medialibrary/15624/conversions/gettyimages-1411244361-micro.jpg)\
\
The popularity of e-bikes and e-scooters is soaring, but are they safe?](https://www.health.harvard.edu/blog/the-popularity-of-e-bikes-and-e-scooters-is-soaring-but-are-they-safe-202409093069) [![blog image 1](https://domf5oio6qrcr.cloudfront.net/medialibrary/13633/conversions/4e378fa8-cfb5-4594-b1e2-9bc6c23c4c11-micro.jpg)\
\
Helping children make friends: What parents can do](https://www.health.harvard.edu/blog/helping-children-make-friends-what-parents-can-do-202303062899) [![blog image 1](https://domf5oio6qrcr.cloudfront.net/medialibrary/15613/conversions/gettyimages-1497999932-micro.jpg)\
\
Want to stop harmful drinking? AA versus SMART Recovery](https://www.health.harvard.edu/blog/want-to-stop-harmful-drinking-aa-versus-smart-recovery-202409053068) [![blog image 1](https://domf5oio6qrcr.cloudfront.net/medialibrary/15609/conversions/gettyimages-2166741669-micro.jpg)\
\
Mpox is back: What to know and do](https://www.health.harvard.edu/blog/mpox-is-back-what-to-know-and-do-202409033067) [![blog image 1](https://domf5oio6qrcr.cloudfront.net/medialibrary/14816/conversions/283a23cd-5029-4943-9bea-3d0eab84713e-micro.jpg)\
\
How well do you score on brain health?](https://www.health.harvard.edu/blog/how-well-do-you-score-on-brain-health-202402023012) [![blog image 1](https://domf5oio6qrcr.cloudfront.net/medialibrary/15010/conversions/14b24cf0-ebd2-43d3-8f8c-4ccd1838241f-micro.jpg)\
\
When should your teen or tween start using skin products?](https://www.health.harvard.edu/blog/when-should-your-teen-or-tween-start-using-skin-products-202403113024) [![blog image 1](https://domf5oio6qrcr.cloudfront.net/medialibrary/15179/conversions/9c2ee9da-d6d9-4ab3-81fa-4e2f021c4b74-micro.jpg)\
\
How — and why — to fit more fiber and fermented food into your meals](https://www.health.harvard.edu/blog/how-and-why-to-fit-more-fiber-and-fermented-food-into-your-meals-202404263036) [![blog image 1](https://domf5oio6qrcr.cloudfront.net/medialibrary/15545/conversions/gettyimages-2148232520-micro.jpg)\
\
Protect your skin during heat waves — here's how](https://www.health.harvard.edu/blog/protect-your-skin-during-heat-waves-heres-how-202408143066)

/

[Diseases & Conditions](https://www.health.harvard.edu/topics/diseases-and-conditions)

# Antidepressants not always effective in people with chronic disease

February 1, 2018

## In the journals

Some antidepressants may not offer much relief for people who battle both depression and a chronic disease, according to research in the Nov. 21, 2017, _Journal of the American Medical Association_.

Nearly half of Americans live with a chronic condition, according to the CDC, and many also suffer from depression, including more than half of Parkinson's disease patients, 41% of cancer patients, and more than 25% of those with diabetes.

The new study included 201 people (73% of whom were men) who had chronic kidney disease and at least moderate depressive systems. Half of them took the antidepressant sertraline (Zoloft) for 12 weeks, while the other half took a placebo. The daily doses ranged from 50 milligrams (mg) daily (the lowest dose) to 200 mg (the maximum dose), based on the person's symptoms and dosage tolerability.

Afterward, the antidepressant group showed no improvement in symptoms compared with the placebo group, based on questionnaires.

Researchers speculated that depression along with a chronic condition may be clinically different from traditional depression, and thus not respond to medications like sertraline. They added that more research is needed to investigate whether depression in the setting of a chronic condition requires specialized treatment, such as other types of antidepressants, cognitive behavioral therapy or other talk therapies, or some combination.

Share This Page [Share this page to Facebook](https://www.facebook.com/sharer/sharer.php?u=https%3A%2F%2Fwww.health.harvard.edu%2Fdiseases-and-conditions%2Fantidepressants-not-always-effective-in-people-with-chronic-disease&display=popup) [Share this page to Twitter](https://twitter.com/intent/tweet?original_referer=https%3A%2F%2Fwww.health.harvard.edu%2Fdiseases-and-conditions%2Fantidepressants-not-always-effective-in-people-with-chronic-disease&text=Antidepressants not always effective in people with chronic disease - Harvard Health&tw_p=tweetbutton&url=https%3A%2F%2Fwww.health.harvard.edu%2Fdiseases-and-conditions%2Fantidepressants-not-always-effective-in-people-with-chronic-disease) [Share this page via Email](mailto:?subject=Great health news for you from the experts at Harvard&body=Check out this link from Harvard Health: Antidepressants not always effective in people with chronic disease - https://www.health.harvard.edu/diseases-and-conditions/antidepressants-not-always-effective-in-people-with-chronic-disease)

Print This PageClick to Print

## Disclaimer:

As a service to our readers, Harvard Health Publishing provides access to our library of archived content. Please note the date of last review or update on all articles.


No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician.


## Recent Blog Articles

[![blog image 1](https://domf5oio6qrcr.cloudfront.net/medialibrary/11789/conversions/27f3a0d2-6570-49be-9964-b1e8a4dd243e-micro.jpg)\
\
Boosting your child's immune system](https://www.health.harvard.edu/blog/boosting-your-childs-immune-system-202110122614) [![blog image 1](https://domf5oio6qrcr.cloudfront.net/medialibrary/15626/conversions/gettyimages-877738018-micro.jpg)\
\
Gratitude enhances health, brings happiness — and may even lengthen lives](https://www.health.harvard.edu/blog/gratitude-enhances-health-brings-happiness-and-may-even-lengthen-lives-202409113071) [![blog image 1](https://domf5oio6qrcr.cloudfront.net/medialibrary/15624/conversions/gettyimages-1411244361-micro.jpg)\
\
The popularity of e-bikes and e-scooters is soaring, but are they safe?](https://www.health.harvard.edu/blog/the-popularity-of-e-bikes-and-e-scooters-is-soaring-but-are-they-safe-202409093069) [![blog image 1](https://domf5oio6qrcr.cloudfront.net/medialibrary/13633/conversions/4e378fa8-cfb5-4594-b1e2-9bc6c23c4c11-micro.jpg)\
\
Helping children make friends: What parents can do](https://www.health.harvard.edu/blog/helping-children-make-friends-what-parents-can-do-202303062899) [![blog image 1](https://domf5oio6qrcr.cloudfront.net/medialibrary/15613/conversions/gettyimages-1497999932-micro.jpg)\
\
Want to stop harmful drinking? AA versus SMART Recovery](https://www.health.harvard.edu/blog/want-to-stop-harmful-drinking-aa-versus-smart-recovery-202409053068) [![blog image 1](https://domf5oio6qrcr.cloudfront.net/medialibrary/15609/conversions/gettyimages-2166741669-micro.jpg)\
\
Mpox is back: What to know and do](https://www.health.harvard.edu/blog/mpox-is-back-what-to-know-and-do-202409033067) [![blog image 1](https://domf5oio6qrcr.cloudfront.net/medialibrary/14816/conversions/283a23cd-5029-4943-9bea-3d0eab84713e-micro.jpg)\
\
How well do you score on brain health?](https://www.health.harvard.edu/blog/how-well-do-you-score-on-brain-health-202402023012) [![blog image 1](https://domf5oio6qrcr.cloudfront.net/medialibrary/15010/conversions/14b24cf0-ebd2-43d3-8f8c-4ccd1838241f-micro.jpg)\
\
When should your teen or tween start using skin products?](https://www.health.harvard.edu/blog/when-should-your-teen-or-tween-start-using-skin-products-202403113024) [![blog image 1](https://domf5oio6qrcr.cloudfront.net/medialibrary/15179/conversions/9c2ee9da-d6d9-4ab3-81fa-4e2f021c4b74-micro.jpg)\
\
How — and why — to fit more fiber and fermented food into your meals](https://www.health.harvard.edu/blog/how-and-why-to-fit-more-fiber-and-fermented-food-into-your-meals-202404263036) [![blog image 1](https://domf5oio6qrcr.cloudfront.net/medialibrary/15545/conversions/gettyimages-2148232520-micro.jpg)\
\
Protect your skin during heat waves — here's how](https://www.health.harvard.edu/blog/protect-your-skin-during-heat-waves-heres-how-202408143066)

/

## Related Content

[![Gratitude enhances health, brings happiness — and may even lengthen lives featured image](https://domf5oio6qrcr.cloudfront.net/medialibrary/15626/conversions/gettyimages-877738018-thumb.jpg)\
\
Mind & Mood\
\
**Gratitude enhances health, brings happiness — and may even lengthen lives**](https://www.health.harvard.edu/blog/gratitude-enhances-health-brings-happiness-and-may-even-lengthen-lives-202409113071) [![Weighing in on weight gain from antidepressants featured image](https://domf5oio6qrcr.cloudfront.net/medialibrary/15497/conversions/3d92a036-7b55-496b-b1d8-7232f86b43fc-thumb.jpg)\
\
Mind & Mood\
\
**Weighing in on weight gain from antidepressants**](https://www.health.harvard.edu/blog/weighing-in-on-weight-gain-from-antidepressants-202408023063) [![Depression more likely during perimenopause than before or after featured image](https://domf5oio6qrcr.cloudfront.net/medialibrary/15453/conversions/8db2cfe8-3818-498f-8a69-38f15e4ccbc9-thumb.jpg)\
\
Women's Health\
\
**Depression more likely during perimenopause than before or after**](https://www.health.harvard.edu/womens-health/depression-more-likely-during-perimenopause-than-before-or-after)

[Depression](https://www.health.harvard.edu/topics/depression) [Medications](https://www.health.harvard.edu/topics/medications) [Mental Health](https://www.health.harvard.edu/topics/mental-health)

## Free Healthbeat Signup

Get the latest in health news delivered to your inbox!

[Sign Up](https://www.health.harvard.edu/healthbeat)

## Footer

[Harvard Health Publishing![Harvard Medical Logo](https://www.health.harvard.edu/img/logos/hhp-grayscale-logo.svg)](https://www.health.harvard.edu)

[Facebook](https://www.facebook.com/HarvardHealthPublications) [Twitter](https://twitter.com/harvardhealth) [Linkedin](https://www.linkedin.com/company/harvard-health-publications/) [YouTube](https://www.youtube.com/channel/UC-jj29vMMB1ulz_uEU5kUrA)

### My Account

- [Customer Service](https://www.health.harvard.edu/customer-service)
- [Log in](https://www.health.harvard.edu/login)

### Order Now

- [Online Learning Courses](https://www.harvardhealthonlinelearning.com)
- [Digital Subscriptions](https://www.health.harvard.edu/subscribe)
- [Special Health Reports](https://www.health.harvard.edu/special-health-reports)
- [Print Subscriptions](https://www.health.harvard.edu/newsletters)

### More

- [About Us](https://www.health.harvard.edu/about-us)
- [Permissions](https://www.health.harvard.edu/permissions)
- [Content Licensing](https://www.health.harvard.edu/licensing)
- [Topics](https://www.health.harvard.edu/topics)
- [Trademark Notice](https://trademark.harvard.edu/pages/trademark-notice)

© 2024 [Harvard Health Publishing®](https://trademark.harvard.edu/pages/trademark-notice) of The President and Fellows of Harvard College


[Do not sell my personal information](https://www.health.harvard.edu/privacy-policy#california-residents) \| [Privacy Policy and Terms of Use](https://www.health.harvard.edu/privacy-policy)

[Scroll To Top](#app)

Close![Harvard Health Publishing Logo](https://www.health.harvard.edu/img/logos/NEW-HHP_logo_stack4.svg)

Thanks for visiting. Don't miss your FREE gift.

**The Best Diets for Cognitive Fitness**, is yours absolutely FREE when you sign up to receive Health Alerts from Harvard Medical School

Sign up to get tips for living a healthy lifestyle, with ways to **fight inflammation** and improve **cognitive health**, plus the latest advances in preventative medicine, **diet and exercise**, pain relief, **blood pressure** and **cholesterol** management, and more.

I want to get healthier

This site is protected by reCAPTCHA and the Google
[Privacy Policy](https://policies.google.com/privacy) and
[Terms of Service](https://policies.google.com/terms) apply.


Close![Harvard Health Publishing Logo](https://www.health.harvard.edu/img/logos/NEW-HHP_logo_stack4.svg)

Health Alerts from Harvard Medical School

Get helpful tips and guidance for everything from **fighting inflammation** to finding the best **diets for weight loss**...from exercises to build a **stronger core** to advice on **treating cataracts**. PLUS, the latest news on medical advances and breakthroughs from Harvard Medical School experts.

BONUS! Sign up now and

get a FREE copy of the

**Best Diets for Cognitive Fitness**

![](/img/healthbeat/shr200px-cognitive_diet_freemium.png)

I want to get healthier

This site is protected by reCAPTCHA and the Google
[Privacy Policy](https://policies.google.com/privacy) and
[Terms of Service](https://policies.google.com/terms) apply.


Close

![Harvard Health Publishing Logo](https://www.health.harvard.edu/img/logos/logo-mark.svg)

Stay on top of latest health news from Harvard Medical School.

Plus, get a FREE copy of the **Best Diets for Cognitive Fitness**.

Sign me up

Close

![Harvard Health Publishing Logo](https://www.health.harvard.edu/img/logos/logo-mark.svg)

Stay on top of latest health news from Harvard Medical School.

Plus, get a FREE copy of the **Best Diets for Cognitive Fitness**.

Sign me up

This site is protected by reCAPTCHA and the Google
[Privacy Policy](https://policies.google.com/privacy) and
[Terms of Service](https://policies.google.com/terms) apply.