Martin Schwarzer: Od podpory Neuronu k publikaci v Science
Je to jedna z bakterií mléčného kvašení. Lactobacilly, např. casei nebo rhamnosus, jsou běžně součástí probiotik. Náš výzkum ale ukazuje, že není bakterie jako ...
bezmikrobních modelů
Během mého postgraduálního studia v laboratoři dr. François Leulier ve Francii jsme došly k výsledkům, které naznačovaly, že naše zkoumaná bakterie bude snižovat dopad podvýživy nejen u <anchor>bezmikrobních modelů</anchor>, ale i u myší s vlastním mikrobiomem. Když jsem odcházel zpět do České republiky, dohodli jsme se s Françoisem, že chceme investovat do dalšího výzkumu čas, peníze i lidskou práci, a že chceme výzkum dotáhnout co nejdál. Dnes už mohu říci, že se nám to povedlo. Právě v této době nastoupil Neuron Impuls, který nám poskytl počáteční finance pro tento výzkum. Pak přišly další granty, které mi umožnily rozšířit výzkumný tým.
Lactobacillus plantarum strain maintains growth of infant mice during chronic undernutrition | Science
Lactobacillus plantarum strain maintains growth of infant mice during chronic undernutrition \| Science

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[Home](https://www.science.org/ "Home") [Science](/journal/science "Science") [Vol. 351, No. 6275](/toc/science/351/6275 "Vol. 351, No. 6275") Lactobacillus plantarum strain maintains growth of infant mice during chronic undernutrition

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# _Lactobacillus plantarum_ strain maintains growth of infant mice during chronic undernutrition

[MartinSchwarzer](#con1), [KassemMakki](#con2), \[...\], [GillesStorelli](#con3), [IrmaMachuca-Gayet](#con4), \[...\], [DagmarSrutkova](#con5), [PetraHermanova](#con6), [Maria ElenaMartino](#con7), [SeverineBalmand](#con8), [TomasHudcovic](#con9), \[...\], [AbdelazizHeddi](#con10), [JenniferRieusset](#con11), [HanaKozakova](#con12), [HubertVidal](#con13), and [FrançoisLeulier](#con14)+11 authors+9 authors+4 authorsfewer [Authors Info & Affiliations](#tab-contributors)

Science

19 Feb 2016

Vol 351, Issue 6275

pp. 854-857

[DOI: 10.1126/science.aad8588](https://doi.org/10.1126/science.aad8588)

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- Contents

- [Microbiota and infant development](#editor-abstract)
- [Abstract](#abstract)
- [Supplementary Material](#supplementary-materials)
- [REFERENCES AND NOTES](#bibliography)

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## Microbiota and infant development

Malnutrition in children is a persistent challenge that is not always remedied by improvements in nutrition. This is because a characteristic community of gut microbes seems to mediate some of the pathology. Human gut microbes can be transplanted effectively into germ-free mice to recapitulate their associated phenotypes. Using this model, Blanton _et al._ found that the microbiota of healthy children relieved the harmful effects on growth caused by the microbiota of malnourished children. In infant mammals, chronic undernutrition results in growth hormone resistance and stunting. In mice, Schwarzer _et al._ showed that strains of _Lactobacillus plantarum_ in the gut microbiota sustained growth hormone activity via signaling pathways in the liver, thus overcoming growth hormone resistance. Together these studies reveal that specific beneficial microbes could potentially be exploited to resolve undernutrition syndromes.

_Science_, this issue p. [10.1126/science.aad3311](https://doi.org/10.1126/science.aad3311), p. [854](https://doi.org/10.1126/science.aad8588)

## Abstract

In most animal species, juvenile growth is marked by an exponential gain in body weight and size. Here we show that the microbiota of infant mice sustains both weight gain and longitudinal growth when mice are fed a standard laboratory mouse diet or a nutritionally depleted diet. We found that the intestinal microbiota interacts with the somatotropic hormone axis to drive systemic growth. Using monocolonized mouse models, we showed that selected lactobacilli promoted juvenile growth in a strain-dependent manner that recapitulated the microbiota's effect on growth and the somatotropic axis. These findings show that the host's microbiota supports juvenile growth. Moreover, we discovered that lactobacilli strains buffered the adverse effects of chronic undernutrition on the postnatal growth of germ-free mice.

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## Supplementary Material

### Summary

Materials and Methods

Figs. S1 to S12

Tables S1 and S2

References ( [_29_](#R29)– [_32_](#R32))

### Resources

File(aad8588-schwarzer-sm.pdf)

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Volume 351 \| Issue 6275

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#### Acknowledgments

The authors thank B. Prud'homme and colleagues at the Institut de Génomique Fonctionnelle de Lyon for critical reading of the manuscript and the Arthro-Tools and ANIRA-ImmOs platforms of Structure Fédérative de Recherche Biosciences (UMS3444/US8) for providing _Drosophila_ and bone microtomography facilities. This work was funded by European Research Council starting grant (FP7/2007-2013-N°309704) (to F.L.), CNRS grant Echange chercheur CNRS/AVCR 13-14 (to F.L. and H.K.), grant P303-12-0535 of the Czech Science Foundation (to T.H.), a 2014 grant from the Fondation Innovations en Infectiologie (FINOVI, to H.V.), and the Institutional Research Concept grant RVO 61388971 (to H.K.). F.L.’s lab is supported by the ATIP/Avenir program, FINOVI foundation, the Fondation Schlumberger pour l'Education et la Recherche, and the European Molecular Biology Organization’s Young Investigator Program. The authors declare no conflicts of interest. A pending patent (WO 2015/173386 A1) applies to methods and data presented in this manuscript. F.L. directed the study, which was designed with M.S.; M.S., K.M., I.M.-G., A.H., J.R., H.K., H.V., and F.L. analyzed and interpreted the data; M.S., D.S., P.H., and T.H. performed the mouse work and animal macroscopic analysis; K.M. and M.S. performed the molecular phenotyping; G.S. and M.E.M. performed the _Drosophila_ work; I.M.-G. performed the study of bone parameters; S.B. performed FISH analyses; and M.S. and F.L. wrote the paper.

### Authors

#### Affiliations

MartinSchwarzer[\*](#cor1)

Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Ecole Normale Supérieure de Lyon, Centre National de la Recherche Scientifique, Université Claude Bernard Lyon 1, Unité Mixte de Recherche 5242, 46 Allée d’Italie, 69364 Lyon Cedex 07, France.

Laboratory of Gnotobiology, Institute of Microbiology of the Czech Academy of Sciences, v. v. i., Novy Hradek, Czech Republic.

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KassemMakki

Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Ecole Normale Supérieure de Lyon, Centre National de la Recherche Scientifique, Université Claude Bernard Lyon 1, Unité Mixte de Recherche 5242, 46 Allée d’Italie, 69364 Lyon Cedex 07, France.

Laboratoire CarMeN, Université Lyon 1, Unité Mixte de Recherche INSERM U-1060 et INRA U-1397, Faculté de Médecine Lyon-Sud, Chemin du Grand Revoyet, 69600 Oullins, France.

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GillesStorelli

Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Ecole Normale Supérieure de Lyon, Centre National de la Recherche Scientifique, Université Claude Bernard Lyon 1, Unité Mixte de Recherche 5242, 46 Allée d’Italie, 69364 Lyon Cedex 07, France.

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IrmaMachuca-Gayet

Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Ecole Normale Supérieure de Lyon, Centre National de la Recherche Scientifique, Université Claude Bernard Lyon 1, Unité Mixte de Recherche 5242, 46 Allée d’Italie, 69364 Lyon Cedex 07, France.

Present address: Institut National de la Santé et de la Recherche Médicale, Université Claude Bernard Lyon 1, Unité Mixte de Recherche 1033, Faculté de Médecine Lyon-Est, Rue Guillaume Paradin, 69372 Lyon Cedex 08, France.

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DagmarSrutkova

Laboratory of Gnotobiology, Institute of Microbiology of the Czech Academy of Sciences, v. v. i., Novy Hradek, Czech Republic.

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PetraHermanova

Laboratory of Gnotobiology, Institute of Microbiology of the Czech Academy of Sciences, v. v. i., Novy Hradek, Czech Republic.

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Maria ElenaMartino

Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Ecole Normale Supérieure de Lyon, Centre National de la Recherche Scientifique, Université Claude Bernard Lyon 1, Unité Mixte de Recherche 5242, 46 Allée d’Italie, 69364 Lyon Cedex 07, France.

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SeverineBalmand

UMR203 BF2I, Biologie Fonctionnelle Insectes et Interactions, Université de Lyon, INRA, INSA-Lyon, F-69621 Villeurbanne, France.

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TomasHudcovic

Laboratory of Gnotobiology, Institute of Microbiology of the Czech Academy of Sciences, v. v. i., Novy Hradek, Czech Republic.

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AbdelazizHeddi

UMR203 BF2I, Biologie Fonctionnelle Insectes et Interactions, Université de Lyon, INRA, INSA-Lyon, F-69621 Villeurbanne, France.

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JenniferRieusset

Laboratoire CarMeN, Université Lyon 1, Unité Mixte de Recherche INSERM U-1060 et INRA U-1397, Faculté de Médecine Lyon-Sud, Chemin du Grand Revoyet, 69600 Oullins, France.

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HanaKozakova

Laboratory of Gnotobiology, Institute of Microbiology of the Czech Academy of Sciences, v. v. i., Novy Hradek, Czech Republic.

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HubertVidal

Laboratoire CarMeN, Université Lyon 1, Unité Mixte de Recherche INSERM U-1060 et INRA U-1397, Faculté de Médecine Lyon-Sud, Chemin du Grand Revoyet, 69600 Oullins, France.

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FrançoisLeulier[\*](#cor1)

Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Ecole Normale Supérieure de Lyon, Centre National de la Recherche Scientifique, Université Claude Bernard Lyon 1, Unité Mixte de Recherche 5242, 46 Allée d’Italie, 69364 Lyon Cedex 07, France.

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#### Notes

\*

**Corresponding author. E-mail: [\[email protected\]](/cdn-cgi/l/email-protection#a4c2d6c5cac7cbcdd78ac8c1d1c8cdc1d6e4c1cad789c8ddcbca8ac2d6) (F.L.); [\[email protected\]](/cdn-cgi/l/email-protection#472a2635332e296934242f3026353d2235072229346a2b3e2829692135) (M.S.)**

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01. - Niklas Grüner,
    - Anna Lisa Ortlepp,
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Pivotal Role of Intestinal Microbiota and Intraluminal Metabolites for the Maintenance of Gut–Bone Physiology, International Journal of Molecular Sciences, **24**, 6, (5161), (2023). [https://doi.org/10.3390/ijms24065161](https://doi.org/10.3390/ijms24065161 "Crossref")
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02. - Ye Tu,
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    - Xin Xu,

The associations of gut microbiota, endocrine system and bone metabolism, Frontiers in Microbiology, **14**, (2023). [https://doi.org/10.3389/fmicb.2023.1124945](https://doi.org/10.3389/fmicb.2023.1124945 "Crossref")
[Crossref](https://doi.org/10.3389/fmicb.2023.1124945)

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Exploring the growing forest musk deer (Moschus berezovskii) dietary protein requirement based on gut microbiome, Frontiers in Microbiology, **14**, (2023). [https://doi.org/10.3389/fmicb.2023.1124163](https://doi.org/10.3389/fmicb.2023.1124163 "Crossref")
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Minocycline-induced disruption of the intestinal FXR/FGF15 axis impairs osteogenesis in mice, JCI Insight, **8**, 1, (2023). [https://doi.org/10.1172/jci.insight.160578](https://doi.org/10.1172/jci.insight.160578 "Crossref")
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A gut bacterial strain rescues stunted growth, Science, **379**, 6634, (756-757), (2023). [/doi/10.1126/science.adg6247](/doi/10.1126/science.adg6247 "Abstract")
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07. - Martin Schwarzer,
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Microbe-mediated intestinal NOD2 stimulation improves linear growth of undernourished infant mice, Science, **379**, 6634, (826-833), (2023). [/doi/10.1126/science.ade9767](/doi/10.1126/science.ade9767 "Abstract")
[Abstract](/doi/10.1126/science.ade9767)

08. - Larissa L. Neves,
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A systematic review of associations between gut microbiota composition and growth failure in preterm neonates, Gut Microbes, **15**, 1, (2023). [https://doi.org/10.1080/19490976.2023.2190301](https://doi.org/10.1080/19490976.2023.2190301 "Crossref")
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Integrative analysis of the metabolome and transcriptome reveals the influence of
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CCFM8610 on germ-free mice
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Modification of the functional properties of chickpea proteins by ultrasonication treatment and alleviation of malnutrition in rat, Food & Function, **14**, 3, (1773-1784), (2023). [https://doi.org/10.1039/D2FO02492F](https://doi.org/10.1039/D2FO02492F "Crossref")
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