To evaluate the safety and tolerability of oral Selatinib Ditosilate Tablets, and explore the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT).~To determine the pharmacokinetic profile of single and multi oral Selatinib Ditosilate Tablets .~To determine preliminary dose and regimen for phase II study of oral Selatinib Ditosilate Tablets.~To assess preliminary antitumor activity .
Brief Description:~This study is designed to evaluate the safety and tolerability of oral Selatinib Ditosilate Tablets, and explore the maximum tolerated dose (MTD) and dose-limiting toxicity in patients with advanced breast cancer.