Investigate the tolerance of Chlorogenic acid for injection in human body, determine the Maximum Tolerated Dose (MTD) and Dose-Limiting Toxicity (DLT) of Chlorogenic acid for injection in the advanced Glioblastoma Patients ;~Determine the human pharmacokinetics characteristic of Chlorogenic acid for injection;~Preliminary observation the effectiveness and effective dose;~Provide the basis for the dosage regimen of phase II/III.
The purpose of this study:~Determining the Maximum Tolerated Dose (MTD), Dose-Limiting Toxicity (DLT), pharmacokinetics characteristic, and dosage regimen of phase II/III of Chlorogenic acid for injection in the advanced Glioblastoma Patients ;