Study aim:~The objective of this proposal is to conduct a pilot clinical trial to determine if the mitochondrial-targeted anti-oxidant MitoQ improves airway reactivity in obese patients with poorly controlled asthma.~Type of Study:~A 14 weeks, prospective, two center (Duke and the University of Vermont), randomized, placebo-controlled, double-masked clinical trial.~Study Population:~40 patients with obesity and poorly controlled asthma.~Intervention:~MitoQ 40 mg per day versus placebo.
A 14-week, randomized, placebo-controlled, double-masked clinical trial in 40 obese patients with poorly controlled asthma.~The intervention is Mitoquinol (MitoQ) versus placebo.~The primary aim of this pilot study is to determine if MitoQ improves airway reactivity in obese patients with asthma.