This is an open-label, Phase II, multi-center study evaluating DM199 in approximately 90 Participants in three cohorts.~Cohort I: African Americans with CKD (Stage II or III), hypertension and non-diabetic Cohort II: Participants with IgA nephropathy diagnosis and CKD (Stage II or III) Cohort III: Diabetes Mellitus (Type II) with CKD (Stage II or III) and hypertension~Participants in each cohort will be enrolled in a parallel assignment to one of two doses:~Dose 1: DM199 2.0 µg/kg SC 2x week for 95 days Dose 2: DM199 5.0 µg/kg SC 2x week for 95 days
An open-label, Phase II, multi-center study evaluating multiple doses of DM199 in participants with chronic kidney disease.