AMP Up aims to define the impact of HIV infection and antiretroviral therapy (ART) on young adults with perinatal HIV infection as they transition into adulthood. A group of uninfected young adults from a similar sociodemographic background and age distribution will be enrolled for comparison.~The primary objectives of this study are:~To identify infectious and non-infectious complications of HIV disease and toxicities resulting from long-term ART, including disease progression, immune dysfunction, viral resistance, end-organ disease, and mortality.~To define the impact of HIV infection and ART on the long-term clinical outcomes of young adults, including:~Metabolic abnormalities and risk factors for cardiovascular disease, including glucose and lipid metabolism, blood pressure, and body composition.~Sexually transmitted infections (Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, syphilis, human papillomavirus, genital warts and HSV) among males and females, and cervical HPV-associated pre-cancers and cancers and Mycoplasma genitalium and other vaginal microbiota among females.~Reproductive health, fertility, and pregnancy outcomes including mother-to-child transmission of HIV.~To define the impact of perinatal HIV infection, its concominant risk factors and ART on long-term neurocognitive and behavioral health outcomes, including:~Mental health and neurocognitive functioning.~Health care behaviors, including adherence to ART, participation in health care services, and transition to adult clinical care.~Risk behaviors, including sexual behavior and substance use.~Independent living skills, and vocational and education achievement necessary for successful transition to adult functioning and quality of life.
This is a prospective cohort study designed to define the impact of HIV infection and antiretroviral therapy (ART) on young adults with perinatal HIV infection (YAPHIV) as they transition into adulthood. A group of uninfected young adults from a similar sociodemographic background and age distribution will be enrolled for comparison.