Patients who have not had adequate blood count recovery post related or unrelated stem cell transplant will be given a boost of T-cell depleted, enriched stem cells to hopefully improve their blood counts.~The unrelated donors will receive G-CSF prior to pheresis (collection of the stem cells) to boost the number of CD34+ cells. The related donors will receive G-CSF and AMD3100 prior to pheresis to boost the number of CD34+ cells. Once the CD34+ cells are collected they will be T-cell depleted using a cell separation device called the CliniMACS systems. The CliniMACS system will select the CD34+ cell and remove the T-cells. By removing the T-cells we can minimize the risk of Graft Versus Host Disease (GVHD). The enriched CD34+ cells will be given to them to hopefully give them a boost of cells that can permanently produce new blood cells to improve their risk of infection and bleeding.
Patients who have not had adequate blood count recovery post related or unrelated stem cell transplant will be given a boost of T-cell depleted, enriched stem cells to hopefully improve their blood counts.