This Phase II randomized study is to determine the efficacy of oral nutritional supplements(ONS) during concurrent chemoradiotherapy for local advanced non-small cell lung cancer, and discuss when to deliver ONS and which indicator should be the goal of ONS.~Patients were randomly assigned to arm A, B, C, D. In arm A, ONS is given from start of CCRT, based on the daily total nutritional intake of 30-35kcal/kg. Patients in arm B are given ONS when they have grade 2 radiation esophagitis, based on the daily total nutritional intake of 30-35kcal/kg. For arm C, ONS is given from start of CCRT, with the goal to keep prealbumin normal. Patients in arm D are given ONS when they have grade 2 radiation esophagitis, with the goal to keep prealbumin normal. All patients received definitive thoracic radiotherapy with total radiation doses of 60-70 Gy, concurrent with weekly docetaxel(25mg/㎡) and nedaplatin(25mg/㎡).
This Phase II randomized study is to determine the efficacy of oral nutritional supplements(ONS) during concurrent chemoradiotherapy for local advanced non-small cell lung cancer, and discuss when to deliver ONS and which indicator should be the goal of ONS.