This Phase 2a study is a 16-week, double-blind, placebo-controlled, randomized study aiming at evaluating the safety and the efficacy of ABX464 given once a day (o.d) at 50 mg in subjects with moderate to severe active Crohn's Disease who have inadequate response, loss of response, or intolerance to prior amino-salicylates, immunosuppressant treatment, biologics, and/or corticosteroid treatment, and followed by a 4 weeks period of follow-up after the last study drug intake.~Eligible patients will be randomized according to a 2/1 ratio in two different groups of treatment : ABX464 50mg OR placebo.~After the treatment phase at week 16, all randomized patients willing to continue with the study treatment will have the possibility to enter a separate open-label study. In that case, patients will stop their participation after week 16, otherwise they will go through the 4 weeks follow-up period and the end of study visit will take place on week 20.
This Phase IIa study is a 16-week, double-blind, placebo-controlled, randomized study aiming at evaluating the safety and the efficacy of ABX464 given once a day (o.d) at 50 mg in subjects with moderate to severe active Crohn's Disease who have inadequate response, loss of response, or intolerance to prior amino-salicylates, immunosuppressant treatment, biologics, and/or corticosteroid treatment, and followed by a 4 weeks period of follow-up after the last study drug intake.