The purpose of the study:~Validation of the use of intentional ultrasound examination, which includes Doppler and elastography for the diagnosis of obstructive venous disease of the liver within 21 days after bone marrow transplantation.~Protocol:~Patients who are planned for a bone marrow transplantaion will be recruited for the study by the staff of the Transplant Department. Inclusion criteria: Patients over the age of 18 before a bone marrow transplantation.~Eligibility criteria: Transplanted under 18 years of age~Research protocol:~After informed consent, patients will undergo an ultrasound examination before the transplant.~The test will include:~Demonstration of liver including its size.~Gallbladder demonstration including its width and wall thickness.~Main portal vein width, Speed and flow direction in main portal vein.~Evaluation of umbilical vein in the falciform ligament to check existence of flow and venous width in case it opened.~Assessment of existence a small / medium or large amount of ascites measurement of resistance index in the main hepatic artery.~Complete elastography examination.~After 14 days and again after 21 days patients will undergo two more US exams, If there is a change in their clinical condition the patients will undergo additional examination accordingly.~At the same time on the 14th and 21st day a clinical evaluation will be performed by the clinical physician in the transplant department based on clinical criteria of European Blood and Brain Transplant Association (EBMT).~The results of the clinical evaluation and blood test results will be collected.~Patients will be divided into two groups:~Control group: Patients who did not develop VOD( veno occlusive disease ) during 21 days.~Study group: Patients who developed VOD during 21 days.~All ultrasound examination data will be compared between the two groups in~In addition will be collected:~Demographics - age, sex.~Background diseases including heart and liver diseases.~Basic disease as a transplantation cause.~All data will be collected anonymously and coded separately.
The purpose of the study:~Validation of the use of intentional ultrasound examination, which includes Doppler and elastography for the diagnosis of obstructive venous disease of the liver within 21 days after bone marrow transplantation.~Protocol:~Patients who are planned for a bone marrow transplantaion will be recruited for the study by the staff of the Transplant Department. Inclusion criteria: Patients over the age of 18 before a bone marrow transplantation.~Eligibility criteria: Transplanted under 18 years of age~Research protocol:~After informed consent, patients will undergo an ultrasound examination before the transplant.~After 14 days and again after 21 days patients will undergo two more US exams, If there is a change in their clinical condition the patients will undergo additional examination accordingly.~At the same time on the 14th and 21st day a clinical evaluation will be performed by the clinical physician in the transplant department based on clinical criteria of European Blood and Brain Transplant Association (EBMT).~The results of the clinical evaluation and blood test results will be collected.~Patients will be divided into two groups:~Control group: Patients who did not develop VOD( veno occlusive disease ) during 21 days.~Study group: Patients who developed VOD during 21 days.~All ultrasound examination data will be compared between the two groups in~In addition will be collected:~Demographics - age, sex.~Background diseases including heart and liver diseases.~Basic disease as a transplantation cause.~All data will be collected anonymously and coded separately.