Besides the main objective, there are 4 other objectives as follows:~To determine dose-limiting toxicity (DLT) of HM781-36B~To determine Maximum Tolerated Dose (MTD) of HM781-36B~To determine the effect of food on the pharmacokinetics after dosed HM781-36B continuously~To evaluate anticancer activity of HM781-36B in patients with advanced solid malignancies
The main objective of this study is to determine the maximum tolerated dose (MTD) of HM781-36B continuously.