PRIMARY OBJECTIVES:~I. To determine the safety profile of high-dose optical dye, indocyanine green, in head and neck cancer surgical patients.~SECONDARY OBJECTIVES:~I. Determine the efficacy of high-dose indocyanine green to identify cancer compared to surrounding normal tissue (tumor to background ratio; TBR) in head and neck cancer resections.~OUTLINE:~Patients receive indocyanine green intravenously (IV) on day 0 and undergo near-infrared image guided surgical resection on day 1.~After completion of study treatment, patients are followed up for 14-30 days.
This phase Ib/II trial studies the side effects of near-infrared image guided surgical resection with indocyanine green in treating patients with head and neck cancer. Near-infrared image guided surgical resection with indocyanine green may make it easier to find and remove tumors.