Study design: Physiological study, controlled, open, non randomised~Healthy male subjects, 18 to 30 years old~Principal objective : To evaluate the influence of metformin on lactate metabolism (production) following exogenous lactate overload.~Objective 2: To evaluate the influence of metformin on lactate metabolism (production) after muscular exercise.~Objective 3: To evaluate the influence of metformin on lactate metabolism (elimination) after exogenous lactate overload.~Objective 4: To evaluate the influence of metformin on lactate metabolism (elimination) after muscular exercise.~Principal outcome : Lactate production following exogenous lactate overload.~Outcome 2: Production of lactate following muscular exercise test.~Outcome 3 and 3': Parameters modelizing elimination of lactate following exogenous lactate overload (bi-exponential model).~Outcome 4 and 4': Parameters modelizing elimination of lactate following muscular exercise test (bi-exponential model).~Inclusion criteria:~Healthy male subjects, 18 to 30 years~Body mass index (BMI) between 21 and 25 kg/m2 inclusive~Informed consent~Exclusion criteria :~Ward of court or under guardianship (sheltered adults)~Adult unable to express their consent~Person deprived of freedom by judicial or administrative decision~Person hospitalised without their consent~Person under legal protection~Existence of a previously diagnosed pathology~Existence of a metabolic condition (obesity, diabetes) or a family history of such~Ongoing medical treatment.
The main objective of this study is to evaluate the influence of metformin on lactate metabolism.~The main outcome is the lactate production following an exogenous lactate overload in healthy male subjects without metformin and one week later with metformin.