This is a randomized, open label, multiple-dose, parallel study to compare PK and to evaluate Drug-Drug Interaction of CG100650 in healthy volunteers.~Total of 39 health volunteers will be randomized to receive either of Group A, B or C for 14 days (13 subjects each).~[Group A] Tramadol +Polmacoxib capsule [Group B] Polmacoxib capsule [Group C] Tramadol~Pharmacokinetic parameters will be evaluated as primary endpoint by changes from baseline;~Safety evaluation will be carried out by conducting vital sign, laboratory test, ECG, and collecting AE, CM by different Group.
This is a randomized, open-label, multiple-dose, parallel, Phase 1 study to compare the pharmacokinetics and to evaluate Drug-Drug Interaction of CG100650 in healthy volunteers.