In this study,~Investigator will apply IOC2 to reflect the depth of analgesic during hypothermia in CPB period.~Furthermore, investigator evaluated the effectiveness of IOC2 monitoring for anesthetic depth versus commonly used vital sign monitoring based on factors such as blood pressure and heart rate.~Evaluate the other sedation co-relation measurement, include BIS , IOC2 to reflected the consciousness during the operation.~Evaluate the other hemodynamic index, include CO, SVV, CVP, PPV to reflect the circulation function , and the effect to the IOC2 and IOC1.~Describe the trend of all the measurement. detect the variation of the index during the temperature change during the CPB.
Investigator will apply IOC2 to reflect the depth of analgesic during hypothermia in CPB period.~effectiveness of IOC2 monitoring for anesthetic depth versus commonly used vital sign monitoring based on factors such as blood pressure and heart rate.~Evaluate the other sedation co-relation measurement, include BIS , IOC2 to reflected the consciousness during the operation.~Evaluate the other hemodynamic index, include CO, SVV, CVP, PPV to reflect the circulation function , and the effect to the IOC2 and IOC1.~Describe the trend of all the measurement. detect the variation of the index during the temperature change during the CPB.