The purposes of this study are:~To evaluate the tolerability of two cangrelor regimens of bolus plus infusion (A and B).~To characterize the pharmacokinetics of Cangrelor (A and B).~To compare the pharmacodynamics of cangrelor regimens with that of an oral 600 mg dose of clopidogrel (A, B, C and D).~To determine the effect of prior cangrelor treatment on the pharmacodynamics of clopidogrel (C and D).~To determine the effect of prior clopidogrel treatment on the pharmacodynamics of cangrelor (Group D).~To determine the effects of concomitant clopidogrel and cangrelor exposure on the pharmacodynamics of clopidogrel (Group D).
The purposes of this study are to:~Evaluate the tolerability of two cangrelor regimens.~Compare the PD of cangrelor regimens with oral clopidogrel.