This study will examine the role of the colon as an endocrine organ with a focus on the secretion of gastrointestinal peptides.~We aim to determine the contribution of the colon to the fasting and postprandial release of gut peptides such as glucagon-like peptide-1 (GLP-1) and peptide YY (PYY). Young healthy men will be examined on three occasions at a clinical research Facility after an overnight fast. On one occasion the colon will also be emptied using a cathartic (picoprep). On two occasions an oral solution of lactulose will be administered to stimulate fermentation by colonic bacteria.
This study will examine the role of the colon as an endocrine organ with a focus on the secretion of gastrointestinal peptides.