Investigational intervention：SSLF or ISFF operations~Study title：A Prospective, Randomized Comparison of Efficacy and Effect on Quality of Life Between Sacrospinous Ligament Fixation and Ischial Spine Fascia Fixation.~Principal Investigator：Chang Ren, M.D., Department of Obstetrics & Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College.~Study subjects：Adult patients with symptomatic stage II~IV pelvic organ prolapse will be eligible if all the inclusion criteria are met and without any reason for exclusion.~Study objectives：The primary objective of this study is to assess the short and mid-term efficacy of Sacrospinous Ligament Fixation and Ischial Spine Fascia Fixation in treating stage II~ IV pelvic organ prolapse and their recurrence rate as well as their impacts on quality of life.~Study design：Prospective, Single-Blind, Randomized, Clinical Trial~Intervention：~ISFF group：Patients receive ISFF according to randomization.~SSLF group：Patients receive SSLF according to randomization~Sample size：76 patients (38 in ISFF group, 38 in SSLF group)~Primary endpoint:~•objective success rates at 3 months after operations.~Secondary endpoints:~peri-operative parameters .~subjective satisfactory rates at 1 year after operations~quality of life questionnaires at 1 year after operations~Safety endpoints: complications
A Prospective, Randomized Comparison of Efficacy and Effect on Quality of Life Between Sacrospinous Ligament Fixation and Ischial Spine Fascia Fixation.