The purpose of this prospective, non-CTIMP, translational study is to assess the feasibility of achieving paired biopsies for immune analysis in patients across five different cancer types: cervical, rectal, Head and Neck cancer, nodal non-Hodgkin lymphoma and cutaneous lymphoma.~All participants will have a minimum of 1 mandatory biopsy (during/post-radiotherapy [irradiated site]) and the potential to have a pre-treatment biopsy if the archival biopsy does not meet the suitability criteria.~Matched blood samples will be collected from participants at baseline, during/post-radiotherapy, and if radiotherapy continues after the on-treatment biopsy is taken, an additional end of treatment blood sample will be collected.~We aim to recruit 10 participants per study arm, with the option to increase numbers in study arms that are recruiting well - a maximum of 100 patients in total will be recruited to the study.
This study aims to investigate immune changes which occur before and following standard radiotherapy in a range of tumour types. We will collect tissue and blood samples before and after radiation treatment from participants across five cancer types: cervical, rectal, Head and Neck cancer, nodal non-Hodgkin lymphoma and cutaneous lymphoma.