Fetal growth retardation affects up to 8% of all pregnancies and has massive short term (increased fetal morbidity and mortality) and long-term (increased incidence of cardiovascular disorders in adulthood) health implications.~Doppler waveform analysis of these pregnancies suggests compromised uteroplacental circulation and placental hypoperfusion.~Our aim is to assess if sildenafil citrate could improve vasodilatation in FGR pregnancies.~Sildenafil citrate may offer a potential therapeutic strategy to improve uteroplacental perfusion in FGR.~Animal studies suggest that phosphodiesterase-5 (PDE5) inhibitors, such as sildenafil citrate, may improve uterine blood flow .
The purpose of this study is to determine whether sildenafil is effective and safe in the treatment of fetal growth restriction.