Specific aims to accomplish this objective are:~Assess the reliability of oligomeric and phosphorylated a-synuclein concentration between two different oligomeric and three phosphorylated asynuclein assays.~Assess the reliability of the oligomeric and phosphorylated a-synuclein concentrations between laboratories~Assess the correlation of oligomeric and phosphorylated a-synuclein concentrations between cerebrospinal fluid and blood.~1.2. Secondary Objectives~To assess the ability of the network of pilot sites to efficiently conduct a study involving biosample collection for PD research. Efficiency will be assessed using measures of the time taken to meet specific milestones within the study.~To assess the ability of the network to collect high quality biospecimens adhering to agreed-upon protocols.~To gauge the willingness of participants to participate in subsequent Fox BioNet studies
The overall objective of this study is to compare the performance of available oligomeric and phosphorylated a-synuclein assay in cerebrospinal fluid and blood.