Randomized, controlled, prospective trial, including ICU patients with Sepsis or septic Shock, at the early phase.~patients will be randomized in 2 groups regarding the hemodynamic management and catecholamin doses:~Group 1: standard hemodynamic goals and cathecolamin infusion to achieve: mean arterial pressure > or equal to 65 mmHg and diastolic arterial pressure > ou equal to 50 mmHg within the first 60 minutes.~Group 2: personalized hemodynamic goals and cathecolamin infusion until normal transcranial doppler: IP<1,2.~For the 2 groups, standard management including: microbiological sampling, early broad spectrum anti infective therapy, fluid management and decreasing of blood lactate levels, will be aimed within the first 60 minutes.~For the Group 2 patients: personalized hemodynamic management will be maintained during 72 hours.
Randomized, controlled, prospective trial, including ICU patients with Sepsis or septic Shock, at the early phase.~patients will be randomized in 2 groups regarding the hemodynamic management and catecholamin doses:~Group 1: standard hemodynamic goals and catecholamin infusion to achieve: mean arterial pressure > or equal to 65 mmHg and diastolic arterial pressure > ou equal to 50 mmHg within the first 60 minutes.~Group 2: personalized hemodynamic goals and catecholamin infusion until normal transcranial doppler: IP<1,2.