To evaluate the Safety and Efficacy of four different short-course regimens of Amphotericin B emulsion in treatment of Kala-azar (visceral leishmaniasis) subjects who are either treatment naive or treatment resistant to other antileishmanial drugs except amphotericin B containing preparations.~To assess the safety and efficacy of single-bolus infusion of Amphotericin B emulsion in treatment of Kala-azar.~Subjects will be administered the study drug in either of the following four dose levels in an ascending manner, starting with the first dosage regimen:~7.5 mg/kg on day 1 and day3 (Regimen 1)~10 mg/kg on day 1, followed by 5 mg/kg on day 3 (Regimen 2)~12.5 mg/kg on day 1, followed by 2.5 mg/kg on day 3 (Regimen 3)~Single-bolus infusion of 15 mg/kg over 2-4 hours on day 1 (Regimen 4)
The purpose of this study is:~To evaluate the Safety and Efficacy of four different short-course regimens of Amphotericin B emulsion in treatment of Kala-azar (visceral leishmaniasis) subjects who are either treatment naive or treatment resistant to other antileishmanial drugs except amphotericin B containing preparations.~To assess the safety and efficacy of single-bolus infusion of Amphotericin B emulsion in treatment of Kala-azar.