The primary objective of this study is to describe a possible effect of metronidazole on PK of budesonide in healthy volunteers.~Secondary objectives:~Effect of budesonide on metronidazole steady-state PK (primarily described as area under the concentration-time-curve).~Urinary 6β-hydroxycortisol (being a marker of CYP3A activity) and cortisol excretion before and during metronidazole multiple-dose co-administration.~Safety parameters.
The primary objective of this study is to describe a possible effect of metronidazole on PK of budesonide in healthy volunteers.