The secondary objectives of this study are:~A. To describe, for 15 healthy volunteers with no history of venous thromboembolism (VTE), plasma nucleosome and DNA concentrations.~B. To describe, for 100 patients with a history of VTE currently consulting for chronic disease or thrombophilia work-up, plasma nucleosome and DNA concentrations.~C. To compare plasma nucleosome and DNA concentrations between healthy volunteers and VTE patients~D. To describe, for 100 patients with a history of VTE currently consulting for chronic disease or thrombophilia work-up, the relationships between classification of VTE and plasma nucleosome concentrations:~anatomical classification of VTE: (i)superficial, deep ((ii)distal or (iii)proximal), or (iv)pulmonary embolism~circumstantial classification of VTE: (i) triggered, no chronic risk factor; (ii) untriggered, with chronic risk factor; (iii)triggered, with chronic risk factor; (iv) untriggered, no chronic risk factor (idiopathic)~E. To describe, for 100 patients with a history of VTE, the variation in plasma nucleosome concentrations 6 months after the first evaluation~according to the above anatomical classification~according to the above circumstantial classification~according to intercurrent events and treatments~F. To compare the plasma concentrations of nucleosomes and free DNA~G. To evaluate the relationship between plasma nucleosome and free DNA concentrations and:~circulating leukocyte populations: total leukocyte count, absolute number of neutrophils, monocytes, lymphocytes~markers of coagulation activation: d-dimers, circulating fibrin monomers~platelet count~patients on antivitamin K: INR, patients receiving heparin: antiXa activity~H. Creation of a biological collection
The main objective of this study is to evaluate, for 15 healthy volunteers and for 15 patients with a history of venous thromboembolism (VTE), the monthly variation (over 6 months) of plasma nucleosome and free DNA concentrations.