Detailed Description:~Additional Study Purpose Details: To assess the pharmacokinetics of metformin and PD 0332334 with concurrent administration.~On February 18th 2009, a decision to terminate further development for PD 0332334 was communicated to investigators in this study. The decision to terminate this study was not based on any safety concerns.
To estimate the effects of multiple doses of PD 0332334 on the elimination of a single dose of metformin from the body~To estimate the effects of multiple doses of metformin on the elimination of a single dose of PD 0332334 from the body~To evaluate the safety and tolerability when PD 0332334 and metformin are administered at the same time.