The aim of this project is to identify genetic risk factors associated with familial papillary thyroid carcinoma (PTC). This can be accomplished in several ways, including loss of heterozygosity studies as well as comparative gene expression analysis. When possible, linkage analysis on families with multiple individuals affected with PTC may also help identify the putative gene(s).~Study participants will be asked to:~Complete family history and medical history questionnaires~Sign a medical record release so that thyroid cancer pathology reports can be obtained~Supply a blood or saliva sample for genetic studies~Provide study related information to family members who are needed for family studies
The aim of this project is to identify genetic risk factors associated with familial papillary thyroid carcinoma (PTC). Papillary thyroid cancer is a type of cancer that shows high heritability. However, the specific genetic factors that cause an increased risk have been elusive.