The primary objective of this protocol is to examine [18F]MNI-1126 as a tool to assess synaptic density loss.The specific objectives are:~Examine [18F]MNI-1126 as a tool to assess synaptic density loss.~To measure the dynamic uptake and washout of [18F]MNI-1126 in the brain using positron emission tomography (PET) in subjects with AD, PD, and healthy volunteers.~To measure blood metabolites of [18F]MNI-1126 and perform kinetic modeling to assess its ability to measure synaptic density loss in the brain using the tracer plasma concentration or a reference region as indirect input.~To acquire safety data following injection of [18F]MNI-1126.
The primary objective of this protocol is to examine [18F]MNI-1126 as a tool to assess synaptic density loss.