Primary parameter :~relationship between coronary flow reserve (CFR) and platelet/plasma BH2 and BH4 levels in patients with hypertension and concomitant cardiovascular risk factors.~Secondary parameter:~Levels of cGMP in platelets.~4. Study design~Three parallel groups of patients (n=15 per group):~Group 1 with normal coronary flow reserve (CFR ≥2.5)~Group 2 with reduced coronary flow reserve (CFR≤2.0)~o Group 3 control subjects (without a high risk profile according to ESC score chart http://www.heartscore.org. ) matched for age (between 40 and 80 years of age)~and gender. 1/3 enrolled patients must be diabetic (Type2 diabetes)
To determine if there is a relationship between coronary flow reserve (CFR) and platelet/plasma BH2 and BH4 levels in patients with high cardiovascular risk .