A Phase 1/2, Open Label Study of SL-401 in Combination with Pomalidomide and Dexamethasone In Relapsed and Refractory Multiple Myeloma.~This study is a Phase 1/2 multi center, open label study of SL-401 in combination with standard doses of Pomalidomide and Dexamethasone. The study will be conducted in 2 Phases: Phase 1 is the dose escalation Phase to determine the MTD or maximum tested dose of SL-401 in combination with standard doses of Pomalidomide and Dexamethasone. In Phase 1, each evaluated SL-401 dose level will incorporate an initial Run-in Cycle (i.e. cycle 1) of single agent SL-401 in at least 3 patients; following the Run-in Cycle, patients who have not experienced a DLT will receive combination SL-401/Pomalidomide and Dexamethasone in cycles 2 and beyond. All patients in Phase 2 will initiate therapy with the combination of SL-401/Pomalidomide and Dexamethasone at the maximum tested dose established in Phase 1 in the same manner (i.e. SL-401 alone in cycle 1 followed by combination of SL-401 and Pomalidomide and Dexamethasone in cycles 2 and beyond).
A Phase 1/2, Open Label Study of SL-401 in Combination with Pomalidomide and Dexamethasone In Relapsed and Refractory Multiple Myeloma