Vancomycin is a drug that requires precise dosing and close monitoring to avoid drug toxicity.~Oftentimes it is used in intensive care units (ICU) for patients who need a life-saving machine for heart and lung failure called extracorporeal membrane oxygenation (ECMO).~There is limited data on the change of vancomycin pharmacokinetics in these patients.~This is a control trial using ICU patients who need vancomycin but not ECMO as a control to understand:~whether the pharmacokinetics of vancomycin is influenced by the use ECMO~design the most appropriate dose of vancomycin in adult patients using ECMO.~After the 4th dose of vancomycin, blood was drawn at appropriate time spots (1 mL each) to determine the time concentration curve and to calculate the pharmacokinetic parameters for 2 groups of patients to determine if there is any difference.
Vancomycin is a drug that requires precise dosing and close monitoring to avoid drug toxicity.~There is limited data on the change of vancomycin pharmacokinetics in patients who need extracorporeal membrane oxygenation (ECMO).~This control trial is to understand:~whether the pharmacokinetics of vancomycin is influenced by the use ECMO~design the most appropriate dose of vancomycin in adult patients using ECMO.