Besides the main objective, there are 4 other objectives as follows:~To assess the safety of Oratecan in combination with capecitabine~To evaluate anticancer activity of Oratecan in combination with capecitabine in patients with advanced solid malignancies~To characterize the pharmacokinetics of Oratecan and its metabolites following oral administration of OratecanTM in combination with capecitabine
The main objective of this study is to determine the maximum tolerated dose (MTD) of Oratecan in combination with capecitabine