Aim: The prediction using diffusion-weighted MRI of the response evaluation in borderline resectable pancreatic cancer.~Study design: Single institution. Single arm. Prospective Phase II Study.~Number of case: 28~Patients: The prediction using dMRI of the response evaluation in borderline resectable pancreatic carcinoma (BRPC) in neoadjuvant therapy.~Disease: Pancreatic carcinoma~Method: To investigate the correlation between pretreatment ADC value of diffusion MRI and pathologic response in patients with borderline resectable pancreatic carcinoma who undergo neoadjuvant therapy.~The correlation between pretreatment ADC value of diffusion MRI and pathologic response evaluated by Evans grade in patients with borderline resectable pancreatic carcinoma (BRPC) who undergo neoadjuvant therapy.~The correlation between pretreatment ADC value at the abutment site of BRPC and the rate of tumor cell destruction.~The correlation between posttreatment ADC value at the abutment site of BRPC and the rate of tumor cell destruction.~The correlation between the ratio of posttreatment/pretreatment ADC value at the abutment site of BRPC and the rate of tumor cell destruction.~The correlation between pretreatment ADC value of BRPC tumor in a largest diameter and the rate of tumor cell destruction.~The correlation between the ratio of posttreatment/pretreatment ADC value of BRPC tumor in a largest diameter and the rate of tumor cell destruction.~ADC Cut-off value which predict more than 50% and less than 10% in tumor cell destruction rate.~The correlation between the ratio of posttreatment/pretreatment ADC value of BRPC tumor in a largest diameter and the ratio of posttreatment/pretreatment SUV max.~ADC Cut-off value and SUV max cut-off value which predict survival time after surgery more than 2 years and less than 2 years.~The comparison of the accuracy of prediction for pathological diagnosis at abutment site between the ratio of posttreatment/pretreatment ADC value and CT scan.~Three correlation between high ADC value/low ADC value/the ratio of posttreatment/pretreatment ADC value and survival time after surgery.~Three correlation between high ADC value/low ADC value/the ratio of posttreatment/pretreatment ADC value and decreasing rate of CA19-9 value.~The correlation between tumor's limb sign in diffusion MRI and the rate of tumor cell destruction more than 10%.
To investigate the correlation between pretreatment ADC value of diffusion MRI and pathologic response in patients with borderline resectable pancreatic carcinoma who undergo neoadjuvant therapy.