The primary objective is to demonstrate the superiority of Traumeel® and Zeel® co-administered intra-articular (IA) injections vs placebo IA injections on the change in knee pain in patients with moderate to severe knee pain associated with osteoarthritis.~The secondary objectives are to evaluate reduction of pain and stiffness and change in physical function.~Safety is evaluated by the incidence of treatment emergent adverse events during the treatment period and follow up period for all randomized patients.
The aim of this study is to evaluate the effectiveness and safety of a combined Traumeel® / Zeel® injection against placebo (saline) in patients with moderate-to-severe pain associated with osteoarthritis of the knee.