This is prospective, observational study, that will be conducted in two high-volume university PCI centers. The centers are: Clinical Hospital Center Zemun-Belgrade, Cardiology Department, and Clinical Center of Serbia, Cardiology Clinic. Study population consists of patients with true coronary bifurcations (Medina 1.0.1; 0.1.1; 1.1.1) with >50% stenosis in both MB and SB9. Patients are scheduled to undergo PCI based on clinical findings. Before PCI, patients will undergo MSCTA. Study hypothesis is that MSCTA before PCI for true non left main bifurcation lesions can determine atherosclerotic plaque characteristics in MB and SB and predict significant narrowing of SB after provisional stenting. Primary goal is to determine which plaque characteristics of true non left main bifurcation lesions in MB and SB, as assessed by MSCTA, can affect the occurrence of SB ostial compromise after provisional stenting. Plaque characteristics that will be investigated include: angle between the arteries, the degree of stenosis, length of stenosis, density of the plaque, plaque volume, positive remodeling of the artery, and presence of spotty calcifications.~Secondary aims are to determine whether MSCTA correctly identifies the degree of stenosis and atherosclerotic plaque composition in MB and SB of bifurcation lesions compared to invasive quantitative coronary angiography and IVUS. Also to determine correlation between endothelial wall shear stress, computed using mathematical model of fluid dynamic reconstruction of MSCTA findings, and the degree of stenosis and atherosclerotic plaque composition in MB and SB of bifurcation lesion. Another goal is to determine correlation between SB stenosis and coronary blood flow after provisional stenting and regional myocardial function assessed by myocardial deformation imaging echocardiography in the area of the left ventricle supplied by SB, immediately after intervention, and after three months. Study patients will be selected based on previous diagnostic coronary angiogram. They will undergo MSCTA on Toshiba Aquilion CXL 128 slice CT scanner using predefined protocol. The procedure will include calcium scoring (Agatston) then CT angiography using Ultravist 370 contrast agent ((iopromide concentration 370 mg/ml, Bayer Health Care, Germany). MSCTA angiograms will be analyzed using dedicated software Vital Vitrea Advanced 6.2, Vital Images, Minnetonka, Minnesota, US. The bifurcation lesion analyses will include: the measurement of the angle between MB and SB, measurement of the lesion length, reference diameter of the vessel, degree of stenosis, atherosclerotic plaque analysis 10 mm proximal and distal in the MB, and 5 mm from the ostium of the SB, and at the level of maximum stenosis (minimal lumen diameter).~Plaque analyses will include:~Type of tissue based on density: lipid, fibro-lipid or calcified,~Plaque volume at the level of bifurcation~Positive remodeling of the artery at the level of bifurcation~Presence of spotty calcification. Before PCI procedure, IVUS evaluation using iLab® Ultrasound Imaging System (Boston Scientific, Natick, Massachusetts, US), of the MB and, if possible, the SB will be performed. Automated pullback at 0.5 mm/s will be used to evaluate both branches before the PCI procedure.~Initial strategy for PCI will be provisional stenting. The choice of vascular access, guiding catheters and coronary wires are left to the operators' discretion. Heparin in doses of 80-100 IU/kg will be used as periprocedural anticoagulation. After placing the guidewires in the MB and SB lesion, the MB will be predilated. After predilation and nitroglycerin administration intracoronary, coronary angiogram will be performed. Based on this angiogram, a second generation drug eluting stent (DES) will be placed in the MB across the SB, so that its diameter will be chosen according to Murray's law. The stent will have to be long enough so that proximal margin of the stent is at least 10 mm proximal to the carina of the bifurcation. After stenting, proximal optimization (POT) of the stent in the MB will be performed using short noncompliant balloon catheter 0,5 mm larger than the diameter of the stent. The distal marker of the balloon catheter will be positioned at the level of carina. Inflation of the balloon catheter must be at least up to the nominal diameter. After POT and intracoronary nitroglycerin administration, coronary angiograms in two orthogonal projections will be done. If the SB does not have more than 75% diameter stenosis (DS) on quantitative coronary angiography analysis (QCA) and/or coronary blood flow less than TIMI III, the procedure is finished. If the SB has more than 75% DS stenosis or TIMI flow <III, procedure will be continued with guidewire exchange, preferably with a third guide wire inserted through the distal strut in the SB. After predilatation of the SB ostium, kissing inflation will be done using adequately sized noncompliant balloon catheters in the MB and SB, up to 6-8 atm. After control coronary angiogram, if the SB has more than 75% DS, TIMI flow < III or ostial dissection, another DES will be implanted in the SB using the technique chosen by the operator. The preferred technique is T and protrusion (TAP).~After the procedure, the patients who had an uneventful PCI will stay in the hospital for 24 h. Blood samples for Troponin I, CK and CK-MB will be collected at 12 and 24 h after the procedure, and for C reactive protein (CRP) after 24h. Complications of the interventions will be documented in the patients study file.~Patients will be seen in the office visit at 1, 3, 6 and 12 months after the procedure. Clinical evaluation and 12-channel ECG are mandatory at each visit. Comprehensive echocardiogram with 2D-strain analysis will be done at 3-month visit. Repeated coronary angiography will be done at 6-month visit, and will include QCA analysis of previously treated bifurcation lesion.
This is prospective, observational study, that will be conducted in two high-volume university interventional cardiology centers. Study population consists of patients with true coronary bifurcations (Medina 1.0.1; 0.1.1; 1.1.1) with >50% stenosis in both main (MB) and side branch (SB). Patients are scheduled to undergo percutaneous coronary intervention (PCI) based on clinical findings. Before PCI, patients will undergo multislice CT angiography (MSCTA). MSCTA before PCI for true non left main bifurcation lesions can determine atherosclerotic plaque characteristics in MB and SB and predict significant narrowing of SB after provisional stenting. Primary goal is to determine which plaque characteristics of true non left main bifurcation lesions in MB and SB, as assessed by MSCTA, can affect the occurrence of SB ostial compromise after provisional stenting. Patients will be seen in the office visit at 1, 3, 6 and 12 months after the procedure. Clinical evaluation and 12-channel ECG are mandatory at each visit. Comprehensive echocardiogram with 2D-strain analysis will be done at 3-month visit. Repeated coronary angiography will be done at 6-month visit, and will include quantitative analysis of previously treated bifurcation lesion.