Pharmacokinetic (PK) studies of DHEA in asthma in general, and severe asthma in particular, have never been done. In many diseases, PK in subjects with disease differs from that of control subjects and those with other conditions. Therefore, researchers are investigating if PK levels of slow release DHEA are different in subjects with severe asthma who have the HSD3B1 AA or AC phenotypes
This is a study to look at pharmacokinetic levels of different doses of slow release DHEA in subjects with severe asthma.