The drug being tested in this study is called TAK-828. TAK-828 is being tested to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics in healthy non-Japanese and Japanese participants in Parts 1 and 2, respectively.~The study will enroll approximately 56 participants. Participants will be randomly assigned (by chance, like flipping a coin) to receive either TAK-828 or matching placebo. This assignment will remain undisclosed to the participant and study doctor during the study (unless there is an urgent medical need).~Proposed doses:~Part 1: TAK-828 15 mg, 45 mg, 75 mg, 100 mg, and placebo twice daily~Part 2: TAK-828 45 mg, and 100 mg, and placebo twice daily~All participants will be asked to take the solution at the same time each day throughout the study.~This multi-center trial will be conducted in the United States.
The purpose of this study is to evaluate the safety and tolerability of multiple oral doses of TAK-828 in healthy participants.