The study objective is to develop a tailored based strategy for ovarian stimulation in IVF patients using AMH, BMI, AFC and inhibin B.~300 patients will be stimulated with rec FSH and an antagonist pituitary inhibition protocol, and randomized (at random computer generated numbers) in 2 arms:~control group: standard care recFSH based on age, basal FSH and AFC.~study group: modified dose of Rec FSH based on AFC with a correction factor based on BMI and basal AMH level.~FSH administration: 20IU per antral follicle (from 2-5mm) corrected as follows:~Correction factor for~AMH:~<1 pMol/L X4 1-6 pMol/L X2 7-18 pMol/L X1 >18 pMol/L X0.5 BMI 16.5-18.5 X0.75 18.5-25 X1 25-30 X1.25 30-35 X1.5 35-40 X2 Primary endpoints: number of mature follicles and eggs collected at egg retrieval; amount of rec FSH used.~Secondary endpoints: fertilization rate; cleavage rate; clinical pregnancy rate; inhibin B and AMH levels during ovarian stimulation.
The study objective is to develop a tailored based strategy for ovarian stimulation in IVF patients using AMH, BMI, antral follicle count (AFC).~300 patients will be randomized in 2 arms:~control group: standard care rec FSH.~study group: modified dose of Rec FSH based on AFC with a correction factor based on BMI and basal AMH level.~Primary endpoints: number of mature follicles and eggs collected at egg retrieval; amount of rec FSH used.~Secondary endpoints: fertilization rate; cleavage rate; clinical pregnancy rate; inhibin B and AMH levels during ovarian stimulation.