OBJECTIVES:~Determine the efficacy of interferon alfa and thalidomide, in terms of time to disease progression, in patients with surgically resected high-risk soft tissue sarcoma or bone sarcoma.~Determine the incidence of metastatic disease and overall survival in patients treated with this regimen.~Determine the clinical and laboratory toxic effects and the tolerability of this regimen in these patients.~OUTLINE: Patients receive interferon alfa subcutaneously three times a week on weeks 1-60 and oral thalidomide once daily on weeks 13-60 in the absence of disease progression or unacceptable toxicity.~Patients are followed every 6 weeks for at least 2 years.~PROJECTED ACCRUAL: A total of 20-48 patients will be accrued for this study.
RATIONALE: Thalidomide may stop the growth of cancer by stopping blood flow to the tumor. Interferon alfa may interfere with the growth of cancer cells. Combining interferon alfa and thalidomide may kill more tumor cells.~PURPOSE: Phase II trial to study the effectiveness of combining interferon alfa and thalidomide in treating patients who have undergone surgery for soft tissue sarcoma or bone sarcoma.