Primary objective and outcome:~The primary objective of the trial is to measure the thermogenic effect of two different doses of whey protein microgels (WPM).~Secondary objectives and outcomes:~Explore the mechanism of action of WPM on thermogenesis including:~Protein turnover in response to the dose and the source of protein (WPM versus casein) Insulinemic and glycemic response to the dose and source of protein (WPM versus casein)~Design: The proposed study is a randomized double-blind, placebo-controlled, single center, crossover design.~At the start of the study, subjects will be randomly assigned to 4 different groups in a crossover design, where they will be asked to consume a beverage containing Product 1: 0g of protein (maltodextrin control) Product 2: 30g of WPM Product 3: 50g of WPM Product 4: 50g of micellar casein (MC) Number of subjects: The number of subjects will be 15. Sufficient subjects should be recruited to provide a 30% drop-out rate. Therefore 20 subjects will be needed including drop-outs.
The main objective of the trial is to measure the thermogenic effect of two different doses of whey protein microgels.~It will be a randomized crossover double-blind design conducted in 20 subjects.