This phase III international, multicenter, open-label, randomized clinical trial is an equivalence study with the hypothesis is that Total Laparoscopic Hysterectomy (TLH) is associated with equivalent disease-free survival when compared to the standard treatment of Total Abdominal Hysterectomy (TAH) for women with apparent Stage I endometrial cancer.~The secondary hypotheses are:~TLH is associated with equivalent or improved Quality of Life (QoL) at 6 months;~TLH is associated with reduced treatment-related morbidity;~TLH is associated with shorter hospital stay;~TLH is associated with less analgesic consumption;~TLH is cost effective;~TLH is associated with improved pelvic floor function.
The primary objective of this study is to assess disease-free survival at 4.5 years postoperatively for women with apparent Stage 1 endometrial cancer, comparing patients who are randomised to receive Total Laparoscopic Hysterectomy (TLH) and patients who are randomised to receive Total Abdominal Hysterectomy (TAH).