Objectives~Principal objective~To analyze the HIV viral sequences present in the CD32 + CD4a + T lymphocytes of the patients who have participated in the ANRS 139 TRIO trial, always followed and in virological success, and carrying multi-resistant viruses archived in the HIV cell reservoir, in order to reconstruct the chronology of the installation of this reservoir.~Secondary objectives~To analyze the HIV viral sequences present in the CD4 + lymphocytes with other membrane HIV reservoir markers, currently being identified, in these same patients~Methodology~Pathophysiological study, in patients infected by multi drug-resistant viruses~Estimated enrollment~21 participants (total and per group)~Intervention~167mL blood sample in EDTA tube:~160mL (16 tubes of 10mL): for IGH (Institute of Human Genetics-Montpellier)~7mL (1tube of 7mL): to measure HIV-RNA in centers~Estimated planning or Study / Trial timetable~Study start date: September 2017~Enrollment period: 12 months~Total study duration: 24 months (analyses included)~Estimated study/trial completion date: September 2019 (one year after enrollment of the last patient)~Study design~Cross-sectional survey, 167mL of blood in EDTA tube will be obtained on a research visit, after signature of written informed consent
To analyze the HIV viral sequences present in the CD32 + CD4a + T lymphocytes of the patients who have participated in the ANRS 139 TRIO trial, always followed and in virological success, and carrying multi-resistant viruses archived in the HIV cell reservoir, in order to reconstruct the chronology of the installation of this reservoir.