The overall goal of this protocol is to evaluate [18F]MNI-968 (aka PF-06730110) as a D1 receptor targeted radiopharmaceutical.~To measure the dynamic uptake and washout of [18F]MNI-968 in brain using positron emission tomography (PET) in healthy volunteers.~To measure blood metabolites of [18F]MNI-968 in the healthy volunteers and to perform invasive as well as non-invasive modeling to assess [18F]MNI-968 binding to D1 receptor.~To acquire safety data following injection of [18F]MNI-968~Evaluation of [18F]MNI-968 PET reliability (test/retest) of several outcome measures
The overall goal of this protocol is to evaluate [18F]MNI-968 (aka PF-06730110) as a D1 receptor targeted radiopharmaceutical.