PRIMARY OBJECTIVES:~I. To determine which drug has the greatest effect on Ang-(1-7) levels in cancer patients with hypertension.~SECONDARY OBJECTIVES:~I. To determine the effect of these drugs on levels of Ang II, VEGF, PlGF, and ACE in the same patients.~OUTLINE: Patients are randomized to 1 of 4 treatment arms.~ARM I: Patients receive oral benazepril hydrochloride once daily on days 1-7.~ARM II: Patients receive oral lisinopril once daily on days 1-7.~ARM III: Patients receive oral ramipril twice daily on days 1-7.~ARM IV: Patients receive oral losartan potassium once daily on days 1-7. In all arms, treatment continues in the absence of unacceptable toxicity.
RATIONALE: Benazepril hydrochloride, lisinopril, ramipril, and losartan potassium may help lower blood pressure.~PURPOSE: This phase II trial is studying how well benazepril hydrochloride, lisinopril, ramipril, or losartan potassium works in treating hypertension in patients with solid tumors.