Proadrenomedullin as a Severity Score and Prognostic Marker in Intra-abdominal Sepsis~Research Type:~Prospective, observational study.~Duration:~October 2016 - October 2017~Associated Medical Centers:~La Paz University Hospital (Madrid), La Princesa Hospital (Madrid), Hospital del Mar (Barcelona), Hospital Clínico de Valladolid and Hospital Clínico de Valencia.~Main Goal:~To measure the value of Pro-adrenomedullin as a prognostic marker and predictor of mortality in patients with intra-abdominal sepsis after damage control surgery.~Secondary Goals:~Make a comparison with other biomarkers (procalcitonin, lactic acid, CRP) and clinical severity scales used in standard critical practice (SAPSII, SOFA).~To establish a correlation between the levels of Pro-Adrenomedullin, the time of stay in critical care units, days of mechanical ventilation and mortality.~Variables:~A. Demographics~B. Date of admission to hospital and date of admission to critical care unit unit~C. Clinical data:~Associated diseases~SAPS II~SOFA~D. Intra-abdominal infection episode data~Systemic response: sepsis / septic shock~Isolated microorganisms in blood cultures and intra-abdominal fluid~Complications related to the infectious process (ARDS, need for mechanical ventilation, vasopressors, disseminated intravascular coagulation, acute renal failure, renal replacement techniques)~E. Follow-up~Critical unit registration date~Date of discharge from hospital~Critical unit mortality, in-hospital mortality and 30 days mortality (assessed by telephone contact if the patient had been discharged).~F. Pro-adrenomedullin levels at admission, 24 and 72 hours. As well as procalcitonin (PCT), lactic acid and polymerase Chain Reaction (PCR) levels.
An observational, prospective study whose main objective is to measure the value of Pro-adrenomedullin as a prognostic marker and predictor of mortality in patients with intra-abdominal sepsis after damage control surgery.