To determine the tolerability, safety, end-organ toxicity and maximum tolerated dose (MTD) of AS1409 in single and repeated doses.~To determine biological responses to AS1409, including interferon-γ and IP-10 circulating concentrations.~To determine preliminary pharmacokinetics of AS1409.~To determine the immunogenicity of AS1409~To explore the anti-tumour activity of AS1409.
To determine the tolerability, safety, end-organ toxicity and maximum tolerated dose of AS1409 in single and repeated doses.