This is a multi-institutional phase II study of pembrolizumab in patients with advanced sarcomas. This study will have two treatment groups, one group for patients with soft tissue sarcoma and one group for patients with bone sarcoma.~Initial enrollment for this study included a total of 86 patients with soft tissue sarcoma and bone sarcomas.~In the expansion portion, there will be an additional 30 patients with undifferentiated pleomorphic sarcoma (UPS) and 30 patients with dedifferentiated or other high grade liposarcoma (LPS) enrolled into the study.
The purpose of this study is to determine the efficacy of pembrolizumab in patients with advanced sarcomas.