Evaluation of the non-inferiority of Vismed® Gel Multi 0.3% in comparison with Vismed® Multi 0.18%, in terms of cornea and conjunctiva staining (Oxford score), on worse eye, between Day 0 and Day 35.~Evaluation of the non-inferiority of Vismed® Gel Multi 0.3% in comparison with Vismed® Multi 0.18%, in terms of cornea and conjunctiva staining (Oxford score), on worse eye, between Day 0 and Day 35.~Comparison of Day 35 versus Day 0 and Day 84 versus Day 0 for each product and comparison between products for the following parameters:~Evolution of cornea and conjunctiva staining (Oxford score) on worse eye.~Evolution of DEQ-5 score (5-items Dry Eye Questionnaire).~Evolution of Van Bijsterveld score (Lissamine green staining) in worse eye.~Evolution of Schirmer test result in worse eye.~Evolution of Tear film Break-Up Time (TBUT) in worse eye.~Evolution of ocular dryness severity by evaluation of each main symptom by the patient and total score of all symptoms~Evaluation of treatment performance by the investigator and the patient.~Evaluation of the average frequency of use over 84 days for both products.
This study is a multicentric, comparative, randomized, investigator-blinded, parallel group study to demonstrate the non-inferiority of Vismed® Gel Multi 0.3% in comparison with Vismed® Multi 0.18% in terms of cornea and conjunctiva staining (Oxford score) on patients with moderate to severe ocular dryness, after 35 days of treatment.