Insulin delivery systems are an increasingly popular treatment option for Type I Diabetes (T1D). Delivery systems consist of an insulin pump, a glucose sensor with a transmitter attached, and a maths program (algorithm) built into the pump. The algorithm uses sensor glucose levels to decide how much insulin should be delivered by the pump.~This study aims to see how well a new algorithm controls blood glucose levels in T1D. The study uses the MiniMed 670G 4.0 insulin pump and compares two different algorithms:~Advanced Hybrid Closed Loop (AHCL - the new algorithm)~Sensor augmented pump therapy with predictive low-glucose management (SAP with PLGM).~Approximately 60 participants with T1D, aged 7 - 80 years, will take part in the study.~Every participant will receive the following two treatment algorithms in random order, with a two-week washout between treatments:~MiniMed 670G 4.0 insulin pump in AHCL mode for 4 weeks.~MiniMed 670G 4.0 insulin pump in SAP + PLGM mode for 4 weeks.~During the study insulin pump data will be uploaded and changes in health will be monitored. In addition, participants will complete 3-day food diaries and a number of questionnaires. Participants at the Dunedin site will also be asked to complete home sleep studies during the trial (optional).~The results of the study will be used to further develop insulin delivery systems. It is hoped this may improve treatment for people with diabetes.
This is a study of the Minimed 670G 4.0 insulin pump, assessing the efficacy of the Advanced Hybrid Closed Loop (AHCL) algorithm in controlling blood glucose levels in Type 1 Diabetes.