Patients will be randomized into two groups:~The first group (Arm A) will receive NCT; (Any approved Chemotherapy protocol by guidelines.~The second group(Arm B) will receive NET; GnRH analog Goserelin acetate 3.6 mg every 4 weeks with tamoxifen 20 mg daily for premenopausal patients or an aromatase inhibitor for postmenopausal patients.~Before and during treatments (every 3 weeks for the NCT group, and every 4 weeks for the NET group), the clinical assessment will be performed for all patients.~All patients will undergo breast magnetic resonance imaging (MRI) before the start of treatment, after 12 weeks (3 months) of treatment, and after the end of treatment before surgery.~We will determine the objective tumor response with every measurement method and assess the response according to the Response Evaluation Criteria in Solid Tumor (RECIST) version 1.1.~Treatment will be continued for 19-21 weeks before surgery for the chemotherapy group and 24 weeks for the endocrine therapy group.~Ki-67 will be assessed using a sample of the core biopsy before treatment and a surgery specimen after treatment.~Adverse events will be recorded at every patient visit and will be assessed according to the Common Terminology Criteria for Adverse Events Version 5.0.~Surgery will be performed between the 24th and 26th week.~Arm B Patients who will develop PD or SD after 6 months of treatment will be shifted to arm A.~The primary endpoint will be;~The clinical response rate at the end of neoadjuvant treatment, as will be determined using caliper and MRI measurements.~A clinical response included either a complete response (CR), a partial response (PR), Progressive Disease (PD), or Stable Disease (SD) according to the (RECIST) version 1.1.~Secondary endpoints will be;~The rate of pathological complete response (pCR).~The rate of breast conservation surgery.~Ki-67 changes.~The length of time to maximum response within a treatment period.~The Adverse events associated with each treatment arm.
Eligible patients will be divided into two groups; one will receive neoadjuvant endocrine therapy and the other one will receive neoadjuvant chemotherapy.