This project aims to:~Define incidence, severity, phenotype, genotype and determinants of the disease in Egypt.~Characterise the phenotype and genotype of several large cohorts with inherited muscle disease and their relatives.~Provide state-of-the-art treatment strategies including medical, surgical and interventional procedures which are patient- and disease-specific.~Study the basic mechanisms responsible for the different phenotypes at a molecular and cellular level including genotype-phenotype correlation.~Provide a special focus for studying patients who are genotype positive and phenotype negative which we believe could yield critical data regarding the evolution of the disease.~Develop sophisticated laboratory studies for single cell electrophysiology and immunocytochemistry and others focusing on the explanted human material from the surgical program.~Define the role of microvascular coronary artery in the development and progression of the disease.~Training Egyptian cardiologists, cardiac surgeons and scientists on state-of-the-art diagnosis and management of heart muscle disease including the latest developments in imaging, novel surgical techniques, coronary physiology, next generation sequencing, bioinformatics and cellular electrophysiology.
Egyptian HCM program aims at defining incidence, severity, phenotype, genotype and determinants of the disease in Egypt, and providing state-of-the-art treatment strategies including medical, surgical and interventional procedures which are patient- and disease-specific.