Study design and study population This study will be randomized, controlled, parallel study.~It will be conducted on 52 patient having with mild to moderate degree ulcerative colitis disease divided into two groups~Group 1 (n=26): Patients will receive conventional treatment only (corticosteroids +immune suppressive +amino salicylic acid) for 3 months.~Group 2 (n=26): Patients will receive previous conventional treatment and Roflumilast (500 mcg ) orally once daily for 3 months~Patient will be selected from Gastroenterology and Endoscopy Unit, Internal Medicine Department, Tanta University Hospital.~A written informed consent will be obtained from all patients~This study will be approved by the Research Ethics Committee of Tanta University.~Any unexpected risks appeared during the course of research will be reported to the participants and ethical committee on time and documented through an adverse effects reporting form .~Randomization will be carried out based on days of hospital admission
This study aims to investigate possible efficacy and safety of Roflumilast in adult patients with ulcerative colitis disease .