The COSMIC trial will be a multicentred, national, parallel-group, pragmatic vanguard pilot trial in adults (≥18 years) who are mechanically ventilated in the ICU with risk factors for LE and an order to extubate has been provided by the treating physician.~The aims of this study are to assess:~Protocol adherence~Recruitment rates~Secondary clinical outcomes will be collected, and if feasibility criteria are met, ultimately used in the powered trial pending no major protocol adjustments (otherwise will be reported as cohort data).
The COSMIC trial will be a multicentred, national, parallel-group, pragmatic vanguard pilot trial.