We will perform paired iliac crest bone biopsies in postmenopausal women who meet standard romosozumab treatment indications and are being prescribed romosozumab by their treating physician. All study volunteers will have a bone biopsy procedure prior to starting therapy, and then an identical procedure at the contralateral side either 3-6 weeks (early) or 6-8 months (late) after starting therapy. This is not a randomized clinical trial testing the efficacy of a drug - we will not be assigning volunteers to a specific osteoporosis therapy, though we will randomize volunteers to either the early or late second biopsy.
The aim of this study is to investigate the effect of romosozumab on bone cells during early and late phases of treatment.