The study is planned as a randomized, double-blind, active comparator-controlled and sham-controlled parallel trial, in which raters and participants will be blinded to the group selection. A total of 60 participants, meeting the eligibility criteria, will be enrolled in the study and divided randomly into 4 groups (2 experimental ones and 2 controls):~EG1 (N=20) rTMS stimulation (1 session daily per 30 days, 3000 pulses per session, session time = 37,5 minutes, 10Hz),~EG2 (N=20) iTBS stimulation (4 short sessions daily per 14 days, 600 pulses per session, session time=3 minutes, 50Hz),~CG1 (N=10) placebo (sham-coil) stimulation based on rTMS protocol,~CG2 (N=10) placebo (sham-coil) stimulation based on iTBS protocol. Efficacy will be analyzed on the intention-to-treat population, defined as participants who completed the baseline and at least one evaluation after rTMS intervention.~The following are the inclusion and exclusion criteria for the recruitment process:~The following stimulation protocols will be used to conduct research into the treatment of depressive disorders:~Stimulation with rTMS within the left hemisphere, in the dorsolateral prefrontal cortex, DLPFC (Dorsolateral prefrontal cortex). In the field of stimulation, a protocol based on FDA recommendations, so- called train stimulation (stimulation of a given frequency for a short period of time with longer breaks without stimulation) assuming the following stimulation parameters:~Magnetic field intensity: 120% of the initial excitability threshold for the motor cortex,~Frequency: 10 Hz for 4 seconds of stimulation,~Breaks in stimulation: 26 seconds,~Total number of stimulation pulses: 3000,~Duration of one session: 37.5 minutes,~Duration of therapy: from 4 to 6 weeks (sessions on days 1-5, break on days 6 and 7).~iTBS protocol in the left cerebral hemisphere, in the dorsolateral prefrontal cortex, DLPFC (Dorsolateral prefrontal cortex). Expected range of parameters:~Frequency: up to 50 Hz, Intensity: 80% excitability threshold for the motor cortex,~Breaks between pulse series: up to 10 seconds~Duration of a single session: from 20 to 190 seconds,~Duration of treatment: 40 sessions,~Total number of pulses in a session: 600, sessions a day: 4.~Duration of one session: 3 minutes,~Duration of therapy: 2 weeks (sessions on days 1-5, break on days 6 and 7).
The study is planned as a randomized, double-blind, active comparator-controlled and sham-controlled parallel trial, in which raters and participants will be blinded to the group selection. A total of 60 participants, meeting the eligibility criteria, will be enrolled in the study and divided randomly into 4 groups (2 experimental ones with active rTMS or iTBS and 2 controls with sham-placebo rTMS or iTBS stimaltions).