Aim~To investigate repeatability and stability of the six OTH-related Bulbicam tests in patients suffering from a) Diabetic retinopathy (DR), b) Age related macular degeneration (AMD) and matched healthy controls (HC).~To compare Bulbicam and the Standard Method on measurements of Visual Field and Pupil~To contribute to the establishment of normal range for DR and AMD patients with different degree in the disease development related to the Bulbicam tests.~To contribute to the establishment of normal range for a normal population without eye-disease related to the Bulbicam tests. Study population The study consists of the following three study populations: 1) Patients suffering from DR of both genders above 18 years of age with different disease degree; 2) Patients suffering from AMD of both genders above 18 years of age with different disease degree; 3) Gender- and age-matched HC without any eye diseases.~Trial equipment Bulbicam will be used in the study and the following six tests will be performed at each investigation: Neurofield 64, Ptosis, Dynamic Acuity, Dynamic Contrast , Dark Adaptation and Pupil RAPD. The Standard Method will be used initially for measurements of Neurofield64, Visual Field and pupil.~Design~The study will be performed as a controlled, open, and non-randomized, stratified observational multicenter study. The stratification factors are the pathology of DR and AMD and the degree of disease. Within each of the four strata, healthy matched controls related to gender- and age (1:1) will be included. The degree of DR is defined as follows:~Mild retinopathy: Mild nonproliferative diabetic retinopathy~Moderate retinopathy: Moderate nonproliferative diabetic retinopathy~The degree of AMD is defined as follows:~Early AMD~Intermediate For each included patient, a gender- and age-matched HC will be included. All included participants will perform Bulbicam eye-investigation twice at three flowing days with a rest period of at least one hour. Each investigation includes same six Bulbicam tests. The Standard method will only be performed once as the first investigation at day 1 for measurements of Visual Field and Pupil~Variables The main variables will be the variables recorded at the six Bulbicam tests The supporting variables will be recorded by the Standard (ST) investigation for DR and AMD.~The central variables related to DR and AMD will be RAPD NDF, Seen /unseen , Time until the given point is recorded as seen, the light in decibel when the point is seen, X- and Y-coordinates and Pupil diameter in mm and OCT RNFL .~Study procedure Participants, who fulfil the inclusion criteria; do not meet any of the exclusion criteria and willing to give informed consent to participate will receive an appointment for starting the study. The Bulbicam examination will be performed twice a day with a rest period of one hour between each registration. This procedure will be repeated the following two days. All demographic data, social factors and history of disease will be recorded at screening. Additionally, the quality of life (QoL) questionnaires EQ-5D-5L developed by EuroQol will be recorded initially as individual baseline values.~The Common Terminology Criteria for Adverse Events (CTCAE) version 4.0 will be used for measuring and classifying the tolerability and toxicity at the end of each day of investigation.~Sample size Sixteen DR patients and 16 AMD patients from each of the two categories will be recruited from the two participating hospitals. All together a total of 16x2=32 patients will be included. For each included patient, one gender- and age-matched HC will be recruited. In total 32 HC.
Aim~To investigate repeatability and stability of the six OTH-related Bulbicam tests in patients suffering from a) Diabetic retinopathy (DR), b) Age related macular degeneration (AMD) and matched healthy controls (HC).~To compare Bulbicam and the Standard Method on measurements of Visual Field and Pupil~To contribute to the establishment of normal range for DR and AMD patients with different degree in the disease development related to the Bulbicam tests.~To contribute to the establishment of normal range for a normal population without eye-disease related to the Bulbicam tests. Study population The study consists of the following three study populations: 1) Patients suffering from DR of both genders above 18 years of age with different disease degree; 2) Patients suffering from AMD of both genders above 18 years of age with different disease degree; 3) Gender- and age-matched HC without any eye diseases.~Study procedure Participants, who fulfil the inclusion criteria; do not meet any of the exclusion criteria and willing to give informed consent to participate will receive an appointment for starting the study. The Bulbicam examination will be performed twice a day with a rest period of one hour between each registration. This procedure will be repeated the following two days. All demographic data, social factors and history of disease will be recorded at screening. Additionally, the quality of life (QoL) questionnaires EQ-5D-5L developed by EuroQol will be recorded initially as individual baseline values.~The Common Terminology Criteria for Adverse Events (CTCAE) version 4.0 will be used for measuring and classifying the tolerability and toxicity at the end of each day of investigation.