The present study is a double-blinded randomized clinical trial with a duration of 12 weeks~. 60 patients with periodontitis stage 2-3, grade B-C, generalized will be allocated in the test (probiotic) and the control (placebo) group at baseline.~The intervention is non-surgical periodontal treatment, which will be applied at baseline and followed for 12 weeks.~Clinical measurements and sampling will be performed at baseline, week 6 and week 12.~Primary endpoint: Changes in microbial composition.~Secondary endpoints: Changes in clinical and immunological parameters
The present study is a double-blinded randomized clinical trial with a duration of 12 weeks.