The research study procedures include screening for eligibility and study treatment including evaluations and follow up visits.~This research study involves the following standard of care interventions:~FOLFOX (leucovorin calcium, 5-Fluorouracil, and oxaliplatin)~Carboplatin~Paclitaxel~Radiation therapy~This research study involves the following study intervention:~- Liposomal irinotecan~It is expected that about 40 people will take part in this research study.~This research study is a Phase II clinical trial. Phase II clinical trials test the safety and effectiveness of an investigational intervention to learn whether the intervention works in treating a specific disease. Investigational means that the intervention is being studied. The U.S. Food and Drug Administration (FDA) has not approved liposomal irinotecan for your specific disease but it has been approved for other uses. The FDA has approved FOLFOX, carboplatin, and paclitaxel as treatment options for this disease.
In this research study, is studying how Liposomal Irinotecan in combination with the standard of care interventions FOLFOX, carboplatin paclitaxel, and radiation therapy affect gastroesophageal junction or esophagogastric cancer~This research study involves the following study intervention:~- Liposomal irinotecan