OUTLINE: Patients are randomized to 1 of 4 arms.~ARM I: Patients receive upper FMT capsules orally (PO) over 2 days.~ARM II: Patients undergo lower FMT via colonoscopy on day 0.~ARM III: Patients receive upper FMT capsules PO over 2 days. Patients receive fiber supplementation PO while on study.~ARM IV: Patients undergo lower FMT via colonoscopy on day 0. Patients receive fiber supplementation PO while on study.~After completion of study treatment, patients are followed up for 180 days.
This phase I trial studies how well fecal microbiota transplant and dietary fiber supplementation work in treating patients with gut graft versus host disease. Fecal microbiota transplant entails inoculating donor stool into a recipient's gastrointestinal tract. Changing the gut microbiome by fecal microbiota transplant and fiber supplementation may help treat gut graft versus host disease.