ALFAOMEGA-RETRÒ, the retrospective mirror protocol of ALFAOMEGA (protocol n. IFOM-CPO003/2018/PO002), has been designed to build a retrospective collection of clinically annotated data and biological samples retrieved from colorectal cancer patients (CRC).~The repository will feed experimental precision research aimed at i) defining a new taxonomy of CRC based on evolutionary patterns (retrospectively assessed on patient's samples), ii) developing and evaluating innovative biomarker-specific therapeutic strategies derived from or together with ALFAOMEGA.~The following data and biological samples will be collected:~Clinical Data (Demographics, Medical History, Cancer Diagnosis & History, Treatment Assessment,).~Imaging Data (CT-Scans, MRI, PET...).~Formalin-Fixed Paraffin-Embedded (FFPE) tissue (either from surgical resections or diagnostic biopsies).~Frozen biological samples (blood, plasma, PBMC, stools, buccal swabs, urines, etc.).
ALFAOMEGA-RETRÒ will be exploited to retrospectively collect clinical and imaging data and archival samples to be used for validation and correlative studies on markers discovered by cutting-edge translational projects within the AIRC5x1000 program Insights into the evolving heterogeneity of colorectal cancer (CRC): from mechanism to therapies (an ongoing multi-institutional research program).