This was a non-interventional retrospective cohort study using the US secondary EHR dataset, Optum EHR, to compare the naive sacubitril/valsartan HFrEF patient population (aged ≥ 18 years) to a matched naive ACEi/ARB HFrEF patient population.~The study comprised of the following periods:~Identification period: 01-Jul-2015 to 31-Mar-2019~Study period~01-Jul-2014 to 31-Mar-2020 for primary objective and secondary objective 2 to 6.~01-Jul-2008 to 30-Sep-2020 for secondary objective 1.~Follow-up period: Patients were followed up until 31-Mar-2020, death or patient transfer out.~Baseline period: 365 days prior to index
A non-interventional retrospective cohort study conducted to compare the naive sacubitril/valsartan Heart Failure with reduced Ejection Fraction (HFrEF) patient population to a matched naive ACEi/ARB HFrEF patient population.