Single ascending dose (SAD), double-blind placebo-controlled study in normal human volunteers.~Secondary objectives:~To evaluate the pharmacokinetics (PK) and eeg biomarker of target engagement of GATE-251 following increasing single doses of GATE-251.~GATE-251 or Placebo: Dose/Mode of Administration: Single dose; oral
To evaluate the safety and tolerability of single ascending doses of GATE-251 in normal human volunteers