The main objective is to determine if there is a reduction in the volume of exudate in the surgical bed with the application of the collagen and polyethylene glycol hemostatic agent.~The present study includes patients undergoing total thyroidectomy for multinodular goiter in the Endocrine Surgery Unit of the Virgen del Rocío University Hospital.~The estimated sample calculation of patients enrolled in the study is 108 (2 groups, 1:1 ratio).~The patients don´t know what type of hemostatic the patients are going to receive (single blind).~The duration of patient follow-up will be 30 +/- 10 days after surgery.
Observational study with non-inferiority, prospective, randomized (1: 1) and open-label medical device. The study has 2 treatment groups (HEMOPATCH® versus standard hemostasis).