The study is a prospective, randomized, multicenter, adaptive design, double blinded clinical study, to evaluate the efficacy and safety of Vibrant Capsule vs. placebo in relieving constipation in subjects with Chronic Idiopathic Constipation.~Two arms will be assessed (at a ratio of 1:1 of Vibrant Treatment vs. placebo):~Vibrant Capsule administered twice a week (Monday and Thursday)~Placebo Capsule administered twice a week (Monday and Thursday) Subjects will come for 4 visits: Screening (visit 1), baseline (visit 2), after 4 treatment weeks from baseline (visit 3) and after 8 treatment weeks from baseline (Final visit , visit 4). A total of 8 treatment weeks.~During the entire study period subjects will be asked to refrain from taking any medications or supplements to relieve their constipation.~Subjects will be authorized to use rescue medication after 3 consecutive days without a bowel movement
The objectives are to assess the efficacy and safety of Vibrant capsule administered twice a week