The study will evaluate the safety of a single administration of PP-007 in patients admitted to a hospital for Acute Ischemic Stroke. PP-007 is pegylated bovine carboxyhemoglobin and will be administered via IV infusion. The effects on collateral flow, infarct size and functional outcome will also be evaluated. Patients will be randomized to either standard of care excluding tPA, or PP-007. Patients may also receive thrombectomy. Other measures include assessment of plasma concentration of PP-007.
The study will evaluate the safety of a single administration of PP-007 in patients admitted to a hospital for Acute Ischemic Stroke. PP-007 is pegylated bovine carboxyhemoglobin and will be administered via IV infusion. The effects on collateral flow, infarct size and functional outcome will also be evaluated. Patients will be randomized to either standard of care excluding tPA, or PP-007. Patients may also receive thrombectomy.