Detailed Description:~Study title: The treatment of Acute Gastrointestinal Injury via ultrasound-guided erector spinae plane block - a prospective, single-center, randomized, controlled trial~Principal Investigator: Professor Wang Hua, Department of Critical Care Unit, Zhujiang Hospital of Southern Medical University~Study subjects: Patients age from 18 to 80 with AGI Ⅱ or greater~Study phase: Investigator Initiated Trial(IIT)~Primary objectives:~To evaluate whether ultrasound-guided erector spinae plane block can reduce the grade of AGI , and improve the cure and remission rate of AGI.~Experimental Group:~On the basis of routine clinical treatment, the ultrasound-guided erector spinae plane block intervention is given. On the first day enrolled, patients are performed with ultrasound-guided erector spinae plane block and cannula will be placed on T8 bilaterally. 0.375% ropivacaine of 20ml is injected separately to both sides with 2ml per hour. Injection is performed twice a day for 7 days or until transferred to the general ward.~Controlled Group:~The patients will receive the clinical routine treatment according of AGI recommended by the 2012 European Society of Critical Care Medicine guidelines, with a uniform nutritional strategy(gastrointestinal dynamic drugs, traditional Chinese drugs and physical rehabilitation therapy).~Course: 7 days Sample size: 100 Sites: 1~Primary endpoints:~the cure rate of AGI~the remission rate of AGI~Secondary endpoints:~critical ill scores~Gastrointestinal function indicators~The inflammatory indicators~the lactic acid(Lac)~cross-sectional area of pyloric antrum(AS) with ultrasound~width of the colons with abdominal X ray or CT~the 28-day mortality~gastrointestinal dysfunction and duration (GIF)~Additional endpoints:~The length of stay in ICU~The total days of hospitalization
In this single-center, randomized, parallel control clinical trial, patients will be randomly assigned to two groups. The treatment group receives ultrasound-guided erector spinae plane block with routine treatment of Acute Gastrointestinal Injury (AGI) for 7 days or until transferred to the general ward, while the control group only receives routine treatment of AGI. The primary outcome is the cure and remission rate of AGI.