This is a dose escalation study in adult participants with GSD1a to determine the safety and tolerability of mRNA-3745 and characterize the pharmacokinetic (PK) and pharmacodynamic (PD) response following IV administration of mRNA-3745.
The main goal of this trial is to evaluate the safety and tolerability of mRNA-3745 via intravenous (IV) administration in participants with GSD1a.