Background, rationale and objectives:~On March 25th 2015 the Ethical Committee from IEO approved the academic study entitled Bone metastases in neuroendocrine tumors (NETs): a survey on natural history, prognostic value and treatment approach, version 1.0 30-Jan-2015. This was a retrospective study led to report how the issue bone metastases from NETs was handle in real practice. Preliminary data related to 321 patients from 18 Italian centers were presented as a poster at the ESMO 2017 congress (Fazio et al. 448P) and they will be included in a manuscript to submit for publication in a peer-review journal. The current protocol regards the continuation of the retrospective analysis, starting since 2014, since the previous study required data collection up to 2013, and at the same time a multicenter prospective observational analysis on the topic.~Duration of the study The study will regard patients fulfilling the eligibility criteria from 2014 to 2021. Data analysis will be completed by the year 2021.
This is a retrospective/prospective observational multicentric trial on patients with bone metastases from NENs.~General objectives:~To trace on a national scale the frequency of bone metastases in patients with neuroendocrine neoplasm (NEN) and their clinical management.~To correlate clinical and biological factors to clinical outcomes.~To centralise and to make homogeneous clinical, pathological, instrumental and therapeutic information.~To set up a database and to acquire biological material for studying predictive and prognostic biomarkers.