The aim of the present study is to evaluate the effect of US guided unilateral ESPB using different volumes of local anaesthetics on analgesic efficacy, dermatomal spread and immunomodulation in breast cancer surgery.~The primary outcome is the analgesic efficacy of the different local anaesthetic volumes of ESPB.~The secondary outcomes are the dermatomal dye spread and sensory coverage, immunomodulation and complications in breast cancer surgery.~Immunomodulation will be assessed by measuring Natural killer cells cytotoxicity.
Prospective interventional study