XT-150 has been safe and well tolerated in clinical studies of intra-articular knee injections for osteoarthritis.~This is the initial study of XT-150 for treatment of neuropathic pain. For this indication XT-150 must be administered by intrathecal injection. Doses used in the osteoarthritis studies will be studied for neuropathic pain.~Upon safety reviews, doses will be increased by cohorts.~The study is placebo controlled and blinded.
Preliminary Evaluation of Safety, Tolerability, and Efficacy of XT-150 for the Treatment of Neuropathic Pain. Intrathecally administered, single injection.