Rapamycin 8% ointment will be applied topically to one of the participant's forearms and matching placebo to the opposite forearm daily for a total of 6 months. After consenting, screening and randomization of arms, the participants will be monitored at monthly visits until study completion.
Topical Rapamycin ointment will be applied to participant forearms to test whether epigenetic changes in the skin are elicited.