45 sites with vertical intrabony alveolar defects will be selected. These defect sites will be allocated randomly into 3 groups as Group I, Group II and Group III.~Group I will be treated with open flap debridement and filled with A-PRF~Group II will be treated with open flap debridement and filled with Bioactive glass (Perioglas®)~Group III will be treated with open flap debridement and filled Bioactive glass (Perioglas®) and A-PRF.
The aim of this study is to evaluate and compare the regenerative potential of Advanced Platelet Rich Fibrin (A-PRF) and Bioactive Glass (Perioglas®) bone graft in the treatment of intrabony defects in chronic periodontitis patients.