The first phase assesses single ascending doses of EDP-297 or placebo in healthy subjects. A fasted and fed two-part cohort will also assess food effect.~The second phase assesses multiple ascending doses of EDP-297 or placebo for 14-days in healthy subjects.~Each cohort within each phase will enroll a total of 8 subjects who will be randomized to receive EDP-297 or placebo. The cohort assessing food effect will enroll 10 subjects randomized to receive EDP-297 or placebo
This study is a randomized, double-blind, placebo-controlled study. It will assess the safety, tolerability, and pharmacokinetics of orally administered single and multiple doses of EDP-297 in healthy adult subjects.