After being informed about the study, all patients giving written informed consent and meeting the eligibility criteria will undergo 4 visits spaced 4 to 6 weeks apart.~The first visit V1 will be about 45 minutes duration. The others ones (V2 to V4) will be about 30 minutes duration.~All sessions will be carried out in the Pneumology Department of the Foch Hospital, volatolomics platform (Exhalomics®).~Exhalation collection will be performed at each visit in order to perform the volatolom analysis.
This is a prospective interventional study to determine whether the profile of volatile organic compounds (VOCs) present in exhaled air (VOLATOLOM) is reproducible in stable severe COPD (Chronic Obstructive Pulmonary Disease) patients.