Assignment: Each study subject will serve as their own control.~Delivery of Interventions:~Prior to the study visit, subjects will undergo a review of their medical history and screening laboratories.~On the days of the inpatient study, the subjects will~Day 1: Undergo q10 min blood sampling for 13 hours~Receive 3 kisspeptin intravenous (IV) boluses~Receive 1 Gonadotropin Releasing Hormone (GnRH) IV bolus~Day 2: Undergo q10 min blood sampling for 13 hours~Receive a naloxone bolus followed by a naloxone infusion~Receive 3 kisspeptin IV boluses~Receive 1 GnRH IV bolus
The goal of this study is to evaluate the effects of opioid antagonists on the hypothalamic-pituitary-gonadal axis in subjects with idiopathic hypogonadotropic hypogonadism (HH).