The current study aims to evaluate feasibility and clinical outcome of exposure-based CBT（ERP）combined with tDCS over the prefrontal cortex (mPFC) in treatment of OCD patients. 60 OCD patients whose symptom were mainly associated with contamination/clean will be randomized into two groups (i.e. ERP+active tDCS or ERP+sham tDCS stimulation). The combined treatment will be performed twice a week for the first two weeks. And for the next 4 week, the treatment for the OCD patients will be undertook once a week. There will be 8 times in total. The investigators will assess thhe OCD patients'symptom severity in baseline, after session 2（the first tDCS+ERP), Session 5 ( four sessions of tDCS+ERP) and Session 10 ( eight sessions of tDCS+ERP) . Through the study, Yale-Brown Obsessive Compulsive Scale（Y-BOCS, the Obsessive Compulsive Inventory-Revised (OCI-R),The Dimensional Yale-Brown Obsessive-Compulsive Scale (DY-BOCS) and the Beck Depression Inventory (BDI), the Beck Anxiety Inventory (BAI), Perceived Stress Scale (PSS), Pittsburgh sleep quality index (PSQI)and side-effect questionnaire will be obtained by a trained investigator. The patients will also receive MRI scan and EEG.
This study aims to evaluate the feasibility and clinical outcome of the Exposure-based Cognitive-Behavioral Therapy (CBT) concurrent with Transcranial Direct Current Stimulation (tDCS) in treating obsessive-compulsive disorder (OCD) patients, and explores the potential neural mechanisms of treatment effect by magnetic resonance imaging (MRI) and electroencephalography (EEG).