Assignment: Each study subject will serve as their own control. The order of kisspeptin doses will be randomized within each set/exposure.~Delivery of Interventions:~Prior to the study visit, subjects will undergo a review of their medical history and screening laboratories. Subjects will also wear a gonadotropin releasing hormone (GnRH) pump prior to the inpatient study visit.~On the day of the inpatient study, the subjects will~Undergo q10 min blood sampling for 6 hours,~Receive kisspeptin intravenous (IV) boluses from hour 6 to hour 44 (20 boluses total),~Undergo q10 min blood samplings for another 6 hours,~Receive a single GnRH IV bolus at hour 51.
The goal of this study is to develop novel treatments for patients with a condition called hypogonadotropic hypogonadism (HH) through the use of exogenous kisspeptin.