Intracranial germ cell tumors originating from the basal ganglia area are rare, accounting for less than 20% of patients. Radiotherapy played a vital role in the treatment of this malignancy. However, the optimal target volume is still undetermined.~Our study regarding relapse patterns of different radiation volumes showed that the ventricular system and ipsilateral frontal lobe were at risk of relapse after focal radiotherapy. Although craniospinal irradiation (CSI) and whole-brain irradiation (WBI) could significantly reduce the relapse in the above areas, the adverse effect on the quality of life is still a concern. As a result, the investigators proposed whole-ventricular irradiation (WVI) in patients with localized basal ganglia germ cell tumors. In order to evaluate its efficacy and safety, the investigators designed this phase II study.
Primary endpoint~three-year disease-free survival of patients with localized basal ganglia germ cell tumors receiving whole-ventricle irradiation~Health-related quality of life measured by PedsQL 4.0 and SF-36~Second endpoint~three-year overall survival of patients with localized basal ganglia germ cell tumors receiving whole-ventricle irradiation~Adverse effects of chemoradiotherapy measured by NCI CTCAE 5.0