This is a prospective cohort study describing the difference in terms of percentage of closed pockets (PPD <5 mm and no BOP) when performing the periodontal re-evaluation at 3-4, 6-8 or 12 months. The trial will follow the recommendations of the Consolidated Standards of Reporting Trials (CONSORT) statement. The study consists of 7 visits over a period of 15 months.~Visit 1 - Baseline -~Informed consent, medical/dental history and demographics~Record concomitant medications and smoking history~Periodontal assessment by a blind and calibrated examiner, consisting of full mouth PPD, REC, BOP, PI, mobility and furcation involvement. PPD, REC, PI and BOP will be recorded at 6 sites per tooth.~Standardized peri-apical x-rays for the sites with PPD≥5mm, as per standard of practice (if not already available within the previous 6 months)~Intra-oral 3D scan~Oral hygiene instructions and demonstration of self-performed oral hygiene measures~PROMs questionnaires~Saliva collection and GCF collection from the deepest pockets (maximum of 5 sites)~Visit 2 and 3 - NSPT - (and extra visit 3.1 and 3.2 if needed) (within 60 days from baseline)~Update medical/dental history and record adverse events and/or concomitant medications~NSPT, consisting in the careful removal of hard and soft deposits with ultrasonic instruments at infected sites performed by an experienced clinician following the principles of minimally invasive non-surgical therapy (MINST). A quadrant approach will be adopted and it will be left to the discretion of the clinician to choose whether to instrument 1 or 2 quadrants at a time and the length of session visits. Hence, 2 to 4 sessions of NSPT with an interval of 1 week between each other will be performed. During NSPT, teeth considered hopeless will be extracted as per standard of practice.~Reinforcement of oral hygiene instructions~PROMs questionnaires~Extra visits outside the study protocol may be arranged in case the patients need extractions or other dental treatments besides NSPT.~Visit 4 (4-6 weeks from the end of NSPT)~Update medical/dental history and record adverse events and/or concomitant medications~Visual inspection of signs of inflammation and plaque~Supragingival polish and reinforcement of oral hygiene instructions~PROMs questionnaires~Intra-oral 3D scan~Visit 5 (3-4 months from the end of NSPT)~Update medical/dental history and record adverse events and/or concomitant medications~Periodontal assessment by a blind and calibrated examiner, consisting of full mouth PPD, REC, BOP, PI, mobility and furcation involvement. PPD, REC, PI and BOP will be recorded at 6 sites per tooth.~PROMs questionnaires~Intra-oral 3D scan~Saliva collection and GCF collection from the same sites identified at baseline~Supragingival polish and reinforcement of oral hygiene instructions~Visit 6 (6-8 months from the end of NSPT)~Update medical/dental history and record adverse events and/or concomitant medications~Periodontal assessment by a blind and calibrated examiner, consisting of full mouth PPD, REC, BOP, PI, mobility and furcation involvement. PPD, REC, PI and BOP will be recorded at 6 sites per tooth.~PROMs questionnaires~Intra-oral 3D scan~Saliva collection and GCF collection from the same sites identified at baseline~Supragingival polish and reinforcement of oral hygiene instructions~Visit 7 (12 months ± 14 days from the end of NSPT)~Update medical/dental history and record adverse events and/or concomitant medications~Periodontal assessment by a blind and calibrated examiner, consisting of full mouth PPD, REC, BOP, PI, mobility and furcation involvement. PPD, REC, PI and BOP will be recorded at 6 sites per tooth.~PROMs questionnaires~Intra-oral 3D scan~Standardized peri-apical x-rays~Saliva collection and GCF collection from the same sites identified at baseline~Supragingival polish and reinforcement of oral hygiene instructions~Photos and videos may be taken/recorded in any of the study visits for documentation purposes. The subject will not be identifiable from those photos/videos.
This is a prospective cohort study that aims to describe the difference in terms of percentage of closed pockets (PPD <5 mm and no BOP) when performing the periodontal re-evaluation at 3-4, 6-8 and 12 months.~Fifty-two, ≥18-year old, otherwise healthy, periodontitis patients will be recruited at Centro di Odontoiatria, Università di Parma.