The potential of cryotherapy application in vitro data indicated that using freezing treatment on VFFs + TGF-β1 (myofibroblast) modulated ECM turnover toward antifibrosis and normalization, attenuated myofibroblast differentiation, reduced cell migration, and weakened the contractile activity. On both VFFs ± TGF-β1, freezing treatment raised LP regeneration (HAS1, decorin).~The findings indicate that cryotherapy may play a protective role in scar formation and contribute to lamina regeneration.~Furthermore the need of this study was developed from the lack in the quantitative knowledge and information in the published studies about the effect of cryotherapy on hypertrophic scar.~This study will be designed to provide a guideline about the effect of effect of cryotherapy on hypertrophic scar height, thickness and discoloration, and to assist in planning an ideal treatment regimen for reducing hypertrophic scar.~Delimitations:~This study will be delimited in the following aspects:~Subjects:~Sixty patients suffering from hypertrophic scar will be randomly divided into two equal groups each one has 30 patients.~Equipment and tools:~2.1. Measurement equipment: Vancouver scar scale. MAPS (Matching Assessment of Scars and Photographs). 2.2. Therapeutic equipment: Gymna Cryoflow ICE-CT. Temperature resistant polymide tape (48 wide).~Hypothesis:~It will be hypothesized that:~Cryotherapy may not have an effect on hypertrophic scar.~Basic Assumptions:~It will be assumed that:~All patients will receive the same kinds of medication and the same nursing care.~All subjects are free from any chronic disease.~All subjects will continue in the study.~All patients will follow the instructions during the treatment
Purpose of the study:~The purpose of the study is to evaluate the therapeutic effect of cryotherpy in treating hypertrophic scar.~It will be hypothesized that:~Cryotherapy may not have an effect on hypertrophic scar.