During the implementation of the project, it was planned to develop a method for the treatment of trophic ulcers using injection of autologous dermal fibroblasts in the wound.~The positive outlook for the effectiveness of photodiode therapy with dermal fibroblasts is due to the following:~the ability of fibroblasts to stimulate tissue regeneration~positive results of preclinical studies of the method of treatment of long-term non-healing wounds in animals (rats).~Twelve patients were included in the study. Dermal fibroblasts were isolated from the skin patients, cultured and then transplanted back to the wound.~The therapeutic dose of cells was 50k per cm2 of the wound area. Follow up patients monitoring was performed at 1, 2 and more months after injection.
Treatment of patients with non-healing wounds and trophic ulcers using local LED phototherapy with local transplantation of autologous dermal fibroblasts