This study will conduct at two centers at the same time: University of Medicine and Pharmacy Center and Cho Ray Hospital. The patients will be consulted to participate to this research from September, 2021 to April, 2023.~Plan for conducting study:~The investigator consults and gets consensus form of the patient with periampullary cancer.~The patient will be prepared for pancreaticoduodenectomy: pre-operative laboratory test, pre-operative biliary drainage, anesthetic checking.~The investigator collected intr-operative data, include type of pancreatic-duodenal reconstruction, type of pancreatic duct's drainage, quantity of blood loss and blood transfusion.~The investor follows post-operative period.~If there are pancreatic fistula appear, the investigator will collect the clinical signs, laboratory test changing, re-operative morphology.~The investigator analysis the risk factors of pancreatic fistula.~Data analysis:~To determine the incidence of pancreatic fistula, the morphology of pancreatic fistula, descriptive statistics will be used.~To determine the risk factors of pancreatic fistula, logistic regression will be used.~Sample size:~The investigator plans to collect 145 patients in the research period.~Plan for missing data:~Any case that miss information will be removed from the study.
Patients who are diagnosed with periampullary cancer will be performed pancreaticoduodenectomy with 3 types of pancreatic-jejunal anastomosis reconstructions. The investigator will analysis the complication of pancreatic fistula about: the clinical symptoms, laboratory test changing, intra-operative morphology, the risk factors