This study was an open-label, three period, fixed sequence study in healthy male and female subjects performed at a single study center.~The study comprised:~Screening during Days -28 to -2 (both inclusive).~Three treatment periods separated by a washout period of at least 10 days.
The purpose of this study is to assess the effect of BIA 5-1058 200 mg on the pharmacokinetic (PK) of treprostinil