Objectives The objectives of the study are as described in the below points.~To develop a questionnaire (Q'SHY) for the identification and screening of subjects with suspected hypothyroidism.~To assess the validity of the designed questionnaire by comparing the outcomes of the responses between General population subjects and treatment naïve subjects group with hypothyroidism.~The study aims to establish a valid questionnaire with a robust sensitivity and specificity to detect signs and symptoms of hypothyroidism.~Inclusion criteria for Subjects The criteria based on which, subjects in each Arm will be chosen to take part in the survey. Arm1: Subjects from the general population who are naïve to their hypothyroid status.~Male and female subjects between the age of 18 years and 65 years~Willing to sign the Subject Authorization Form (SAF) Arm 2: Subjects who are newly diagnosed patients of Hypothyroidism and are treatment naïve*.~Male and female subjects between the ages 18 years and 65 years.~Subjects who had symptoms of hypothyroidism were seen by a physician and diagnosed with hypothyroidism after laboratory testing of Thyroid Stimulating Hormone > 4.5 Milli international units per litre(mIU/L) within 2 weeks from the date of the survey~Willing to sign the SAF~Willing to provide their Thyroid Function Test report that was used to diagnose Hypothyroidism. * Treatment naive diagnosed on basis lab and clinical diagnosis within last 2 weeks~Exclusion criteria for subjects Arm 1: Subjects from the general population who are naïve to their hypothyroid status~Individuals less than 18 years of age and more than 65 years of age.~Pregnant or lactating females Subjects previously diagnosed with and received treatment for thyroid diseases.~Subjects not willing to sign the SAF.~Arm 2: Subjects who are newly diagnosed patients of Hypothyroidism and are treatment naïve~Individuals less than 18 years of age and more than 65 years of age.~Pregnant or lactating females~Subjects previously diagnosed with and received treatment for thyroid diseases.~Patients on treatment for Thyroid diseases Subjects not willing to sign the SAF.~The above-mentioned criteria will be applicable to both Face validation and Pilot survey.~Subjects are divided into 2 arms, with 100 subjects in each arm.~Phase -1~Arm 1: Sixteen subjects from the general population who are naïve to their hypothyroid status with equal distribution of males and females.~Arm 2: Sixteen subjects who are newly diagnosed patients of Hypothyroidism are treatment naïve with equal distribution of males and females~Phase -2~Arm 1: One hundred subjects from the general population who are naïve to their hypothyroid status with equal distribution of males and females~Arm 2: One hundred subjects who are newly diagnosed patients of Hypothyroidism are treatment naïve with equal distribution of males and females
Type of Study Questionnaire- Development and validation~Information about the Q'SHY:~The Q'SHY- Questionnaire for Screening of Hypothyroidism is a Patient Reported Outcome (PRO) tool to enable screening for Hypothyroidism in the general population.~It is a 20-item questionnaire which covers aspects of the symptoms of Hypothyroidism and incorporates the contributory factors from patient history which when combined, provides a robust tool to effectively screen the population.~The questionnaire content is being created based on a thorough search for relevant literature and encompasses all important aspects for screening purposes