Transarterial chemoembolization (TACE) is commonly used for the treatment of advanced hepatocellular carcinoma. Early randomized trials suggested that TACE can be accepted as the standard treatment for advanced-stage disease. However, the outcome of patients treated with TACE in real-life cohorts is still very poor.~Recent studies have also supported a safe combination of immune checkpoint inhibition with TACE. And the combination of sintilimab plus bevacizumab biosimilar showed significantly improved survival in advanced HCC. Therefore, the objective of this study is to evaluate the efficacy and safety of TACE combined with anti-PD-1 antibody in patients in advanced hepatocellular carcinoma.
The objective of this study is to evaluate the efficacy and safety of TACE combined with Sintilimab plus bevacizumab biosimilar in patients with advanced hepatocellular carcinoma as first-line therapy.