This research study is a randomized controlled trial that will compare an exercise group to a control group on lower extremity function, CIPN, and inflammatory markers in ovarian or endometrial cancer patients undergoing first-line chemotherapy after surgery.~The names of the study interventions involved in this study are/is:~Aerobic and resistance exercise; virtually supervised 16-week aerobic and resistance exercise performed at home via Zoom~Attention control for 16 weeks, home-based stretching~The research study procedures include: screening for eligibility and study interventions including evaluations and follow up visits.~It is expected that about 30 people will take part in this research study.
The purpose of this research is to determine whether a 16-week virtually supervised aerobic and resistance exercise program is feasible in patients receiving first-line chemotherapy after surgery for ovarian or endometrial cancer and if it will improve lower extremity function (function of the legs), lessen chemotherapy-induced peripheral neuropathy (CIPN; numbness or tingling in the hands or feet), and if there is any effect on inflammatory blood markers (the level of a certain marker in the blood that is associated with inflammation; redness and swelling).