This is a Phase 2 randomized trial testing the safety and effectiveness of NTS-WBRT (normal tissue sparing whole brain radiation therapy) as compared to HA-WBRT (hippocampal avoidance whole brain radiation Therapy) in treating brain metastases.~NTS-WBRT is a targeted radiation therapy that further reduces radiation dose to tissue that does not need radiation therapy treatment. HA-WBRT is a targeted radiation therapy that avoids the hippocampus (part of the brain that controls learning and memory) tissue during radiation therapy treatment.~The research study procedures include screening for eligibility and study treatment including evaluations and follow up visits.~It is expected that about 100 people will take part in this research study.
This research is being done to compare quality of life and symptom burden in participants who receive two different types of radiation therapy (normal tissue sparing whole brain radiation therapy (NTS-WBRT) or standard of care hippocampal avoidance whole brain radiation Therapy (HA-WBRT).~This research study involves:~NTS-WBRT (normal tissue sparing whole brain radiation therapy)~HA-WBRT (hippocampal avoidance whole brain radiation Therapy)~Memantine standard of care drug