OUTLINE:~Participants undergo collection of blood and urine samples every 12 months, and when any biopsy occurs for up to 10 years, and if relevant, at time of curative therapy and 12 months after completion of curative therapy.
This study investigates ways to detect prostate cancer earlier in men who are at increased genetic risk of developing prostate cancer that forms, grows, or spreads quickly (aggressive). Studying samples of blood, urine, and/or tissue in the laboratory may help doctors further understand the genetics of prostate cancer and help identify ways to detect cancer earlier, thereby improving treatment and methods of early detection in the future.