Study Objectives:~Primary:~-To assess the efficacy of hypofractionated radiotherapy followed by immediate surgical resection in the treatment of soft tissue sarcoma~Secondary:~- To assess the side effect profile, late side effects criteria, and major and minor post-operative complication rates.~Exploratory:~To assess patient related factors which may influence wound complication rates.~To assess patient-reported functional and satisfaction outcomes.~To assess margin status and percent necrosis at time of surgery.
The trial will use neoadjuvant hypofractionated radiotherapy followed by immediate surgical resection in the treatment for soft tissue sarcoma. It will allow patients to be treated over the course of 1-2 weeks with similar local control rates compared to the traditional 2-3 month timeline. Additionally, it is proposed that this will be possible without increasing the risk of wound complications compared with a traditional 5-6 week course of pre-operative radiation.