This is an open-label, single-arm, phase I trial. The purpose of this study is to :~Test a safe and tolerable dose of TY-302 single and the combination with Tamoxifen~Determine the response rate of the combination~Further evaluate the safety and side effect profile for the combination of TY-302 and Tamoxifen.
The primary objective of this study is to evaluate the safety and tolerability of TY-302 single and the combination with Tamoxifen in dose-escalation and dose-expansion study.The drugs involved in this study are:~TY-302~Tamoxifen