As part of the innovation fund project PRÄP-GO (EA1/225/19), a multimodal intervention is being conducted in patients with a frailty syndrome. However, the health care research project is limited to evaluating clinical issues only. In order to be able to research further pathophysiological, clinical, psychosocial and work-organizational connections, different groups of participants will be offered the participation in this scientific support program of PRÄP-GO.~The groups of participants in this accompanying program ANA-PRÄP-GO are:~Randomized study patients with a frailty syndrome of the intervention study PRÄP-GO (PG cohort)~Non-frail surgical control group (NFC cohort)~Non-surgical comparison group (NO cohort)~Participants with health professions (GB cohort)~Additionally, relatives of the patients can be included.~Subprojects are included to reflect research questions of interest in sub groups:~Success of endoprosthetic implants (clinical outcome and gait pattern after total hip arthroplasty and total knee arthroplasty in frail patients)~Functional treatment outcome and health-related quality of life after elective spinal surgery in the PG cohort, in the NFC cohort, and in the NO cohort~Hemodynamic evaluation in patients of the PG and NFC cohort with preoperative abnormal cardiovascular function~Establishment of a German standard database for 14 CANTAB tests by CANTAB Connect technology~Aggregated evaluation of the cognitive data of different surgical cohorts from studies carried out at the department of anesthesiology to describe domain-specific changes in the perioperative course~Perspectives of different health professional groups regarding barriers and facilitators in the implementation of a prehabilitation program and necessary changes in skill, organizational and management, and communication in an interdisciplinary setting~Perspectives of patients and significant others regarding the organizational pathway of the prehabilitation program~Frequency, pathophysiology and trajectory of muscle weakness as well as functional impairments of patients admitted to intensive care units of the PG and NFC cohort and their long-term outcomes.~The gut microbiome as a potential risk factor for perioperative neurocognitive disorders (PNDs) in the elderly~Evaluation of nutrition data in all cohorts (e.g. adherence to mediterranean diet, nutrition habits, nutritional status, dental status etc.)
The patients included in PRÄP-GO and the corresponding comparison cohorts will be offered to participate in this complementary study in order to be able to carry out a detailed characterization and phenotyping of the frailty complex.