The objectives for the study are listed below:~Primary Objectives~-Determine the safety, and feasibility of administration of several dose combinations of conventional T-cells (Tcon) and regulatory T-cells (Treg)~Secondary Objectives~To determine the GVHD-free relapse-free survival (GRFS) post-HCT~To determine the overall survival (OS) post-HCT~To measure the incidence and severity of acute and chronic GVHD
Reduced intensity conditioning (RIC) has been increasingly adopted as a modality to allow preparative conditioning pre-transplant to be tolerated by older adults or those patients that are otherwise unfit for myeloablative conditioning. In this study Reduced intensity conditioning (RIC) conditioning is used and followed by match aploidentical donor peripheral blood stem cell transplantation.