The specific aims of this study are:~To establish hypoxia imaging in NPC patients~Investigate the dynamics of tumor hypoxia before and during chemoradiation~Integrate hypoxia imaging into radiation treatment planning protocols~Design hypoxia adapted radiation schedules~Identify candidate hypoxia biomarkers
This study aims to investigate the use of 18F-FMISO PET in identifying hypoxic subvolume for dose escalation radiotherapy in nasopharyngeal cancer and thus improve local control without significant increase in toxicities.