Primary outcome:~1. Hospital survival~Secondary outcomes:~Duration of vasopressor therapy~Requirement for renal replacement therapy in patients with Acute Kidney Injury (AKI)~ICU length of stay (LOS)~Change in serum procalcitonin (PCT) over first 72 hours~Change in SOFA score over first 72 hours (measured as SOFA score daily for four days, with day one being admission, then 3 days after, totaling 4 days of treatment with HAT)~Procalcitonin clearance (formula = initial PCT - 72 hour PCT divided by initial PCT x 100)~Number of wound related surgeries~Wound status at time of hospital discharge:~Open~Closed
Evaluate the impact of HAT therapy versus placebo in the treatment of patients with an acute NSTI and sepsis.