Population and Methods The study will be conducted at the otorhinolaryngology department in Assiut University Hospital.~Study design: prospective randomized controlled trial.~.~Methodology:~After fulfilling all inclusion and exclusion criteria all patients will be subjected to~A. Full history taking including :~Personal History~History of sinonasal symptoms (nasal obstruction, nasal discharge, headache, hyposmia, sneezing, itching, facial pain…etc)~History of nasal surgery.~Other ENT symptoms~General symptoms suggestive of atopy~History of general medical illness.~B. Examination :~1. General examination.~2. Full ENT examination.~3. Nasal endoscopy.~C. Investigations :~Multi-slice computer tomography (MSCT) of nose and paranasal sinuses axial, coronal and sagittal cuts without contrast .~D. Management :~Patients will be divided into 2 equal groups. Patients in group A will be treated with fluticasone furoate nasal: (50 micrograms /spray ) 100 micrograms (2 sprays) in each nostril twice daily plus oral montelukast (montelukast 10 mg, once a day) for 3 monthes and oral Prednisolone 40 mg/day for two weeks. Subjects in treatment group B will receive topical and systemic steroids in an identical regimen only.~.
The aim of the work is to examine the efficacy of montelukast as an adjunct to steroid therapy in patients with chronic rhinosinusitis with nasal polyps.