The exponential increase in the production/use of plastic translates into a parallel increase of environmental plastic-waste that is continuously degraded into micro and nanoplastics (MNPLs). Information on the MNPLs' effects on human health is still preliminary and, furthermore, the limitations in current methodologies prevent accurate human exposure/risk assessment.~This observational study will obtain biological samples of hemodialysis Chronic Kidney disease (CKD) patients as a reference and vulnerable group of individuals highly exposed to MNPLs and potentially more susceptible. This allows the optimization of specific biomarkers of human MNPLs exposure and the characterization of biomarkers of early effect that allows an association between the exposure to MNPLs and effects on human health.
Micro and nanoplastics (MNPLs) effects on human heath is still preliminary. Chronic kidney disease (CKD) participants, specially does patients submitted to hemodialysis, is a population high exposed to plastics. The objective of our research is to be able to detect MNPLs on biological fluids of hemodialysis patients as well as their potential genotoxic and immunological damage.