A total number of 40 volunteers will be enrolled in the study. Each volunteer will receive two peripheral nerve blocks (one in each leg) on the day of participation. This will result in 80 peripheral nerve blocks. The types of nerve blocks given to each leg on each volunteer will depend on randomization.~The 80 nerve blocks are divided into five groups specified by type of nerve block, volume of anesthetic used, and respective numbers of legs used in the group. The groups and specifications are listed here:~Groups name, type of peripheral nerve block, study medication dosage and number of legs in the group:~Group A: PPB with 10 ml of lidocaine 1%, 20 legs.~Group B: PPB with 20 ml of lidocaine 1%, 20 legs.~Group C: PPB with 30 ml of lidocaine 1%, 20 legs.~Group FNB: FNB with 20 ml of lidocaine 1%, 10 legs.~Group SNB: SNB with 20 ml of lidocaine 1%, 10 legs.~Group FNB of SNB are performed unblinded and works as active comparatives for model control, in order to establish reference points for when a nerve is considered affected.~Prior to nerve block procedure , pre block assessments are obtained in the following order:~Sensory test of the saphenous nerve.~MVIC by ankle plantarflexion.~MVIC by ankle dorsiflexion.~MVIC by knee extension.~Compound muscle action potential (cMAP) recordings in the following order:~Nerve to vastus medialis muscle~Nerve to vastus lateralis muscle~Nerve to tibialis anterior muscle~Nerve to gastrocnemius muscle~60 minutes after the block performance, post block assessments are done. Values are obtained in the same order as for the pre block assessments.~A peripheral intravenous line is inserted prior to the procedure of the peripheral nerve block is performed. At the discretion of the anesthetist, up to 20 mg Propofol IV may be provided to ease the patient during the nerve block procedure. The volunteer is monitored with continuous electrocardiography and pulse oximetry for the first 30 minutes after block performance and clinically hereafter. Final check by an investigator to ensure the volunteer is ready to go home. If the muscle strength is reduced, the volunteer will not be sent home before the ability to walk safely with crutches is ensured.
The aim of this study is to evaluate the Popliteal Plexus Block (PPB) effect on motor nerve branches of the sciatic and femoral nerve, when using different volumes of local anesthetics for PPB.~The hypothesis is that increasing the volume of anesthetics used for PPB will spread to the sciatic nerve leading to a reduced muscle strength in the lower leg and decreased nerve conduction velocity in the nerve to gastrocnemius muscle (the tibial nerve) and the nerve to anterior tibial muscle (the deep fibular nerve).~The effects will be evaluated by maximum voluntary isometric contraction (MVIC) of the lower leg muscles and by recordings of the compound muscle action potential (cMAP) of the gastrocnemius and tibialis anterior muscles - a motor nerve conduction study.~In addition, evaluation of PPBs effect on the femoral nerve is done by MVIC of the quadriceps femoris muscle, cMAP of the vastus medialis and vastus lateralis muscles and by a sensory nerve conduction study of the saphenous nerve.