The aim of this study is to establish a prospective clinic-biologic database of patients treated by immunotherapy. This database will allowed to carry out works (such as translational research) aiming at assessing immunotherapy in real life situation.~Other objectives of the study include:~Describe overall survival, progression-free survival, response to immunotherapy (in particular hyper-progression, pseudo-progression) considering the first tumor assessment and the best response, prolonged response~Identifying prognostic factors of overall survival, progression-free survival, hyper-progression, best response under immunotherapy~Describe AEs (Adverse Events) potentially associated with immunotherapy, their kinetics of appearance, from the start of treatment and after the end of treatment in order to assess the risk of delayed appearance~To identify factors associated with increased risk of severe adverse event (grade > 2 or leading to end of treatment) potentially related to immunotherapy, from the beginning of immunotherapy to 1 year after this start of the treatment, in patients who received at least 4 doses or who stopped the treatment earlier (before 4 doses) due to toxicity.~Identifying delayed adverse events potentially related to immunotherapy, occurring between 90 days and 1 year after the treatment discontinuation, in patients who received at least 4 doses or who stopped the treatment earlier (before 4 doses) due to toxicity.~To identify and describe rare toxicities~To evaluate the association between co-medications and disease evolution~To evaluate the association between co-medications and toxicities occurrence~Translational research objectives:~To identify biomarkers that might be associated with tumor response and/or toxicity of immunotherapy from:~Establishment of serum and plasma bank which will be used for diverse works;~A systematic analysis of the lymphocyte profile~To study the impact of tabagism on efficacy and toxicity of immunotherapy from systematic collection of urinary cotinine.
ImmuCCo-1905 is a monocentric interventional study on patients treated by immunotherapy, which consist in establishment of a prospective clinic-biologic database over 5 years, associated with a biobank. This database will allow carrying out works aiming at assessing immunotherapy in real life situation.