A minor amendment was submitted to allow histological and immunohistochemical analysis of the samples.
Safety and feasibility study investigating brain biopsy in severe head injury. When a patient undergoes craniotomy or ICP bolt insertion for trauma, a biopsy of brain tissue is taken.~Blood, saliva, urine and faeces samples are also taken for 7 days following the brain biopsy.~CSF is collected if a CSF drainage device is used.