The primary purpose of this study is to assess the effect of repeated subcutaneous administration of ponsegromab (PF-06946860) on frequency, severity, and burden of symptoms as well as physical limitations in participants with heart failure and elevated circulating GDF-15 concentrations. The study will also assess the safety, tolerability, PK, PD, and immunogenicity of ponsegromab.
The purpose of this clinical trial is to compare the effects of study medicine (Ponsegromab/PF-06946860) with a placebo (A pill that looks like the study medicine but does not contain the active medicine) to find out if the study medicine is better than the placebo (a pill that looks like the study medicine but does not contain the active medicine) for treatment of symptoms related to heart failure. Participants will not know which treatment group they are assigned to. All participants in this study will receive the study medicine or placebo by shots under the skin every four weeks. People may be able to participate in this study if they have the heart failure. Participants will take part in this study for about 9 months. During this time participants will visit the study clinic once a month.