OUTLINE:~Patients receive psilocybin orally (PO) and participate in group and individual therapy sessions on trial.
This phase I/II trial tests the safety and side effects of psilocybin in combination with therapy for the treatment of patients with cancer for which no treatment is currently available. Psilocybin is a substance being studied for the treatment of anxiety or depression in patients with advanced cancer. It is taken from the mushroom psilocybe mexicana. Psilocybin acts on the brain to cause hallucinations (sights, sounds, smells, tastes, or touches that a person believes to be real but are not real). Giving psilocybin in combination with therapy may decrease anxiety in patients with metastatic cancer.