Forty migraine patients, according to the International Classification of Headache Disorders 3rd edition, aged 10-55 years with migraines. Our selected patients were naive, and they didn't receive any prophylactic therapy for migraine before.~for each patient, the investigators did~detailed history taking with stress on Age, sex, and criteria and type of migraine~general examination~full neurological examination: Full neurological examination~Laboratory investigations include: Serum creatinine, Liver functions test to exclude any metabolic disorder.~Approximately 5 ml of venous blood was drawn from all participants and then centrifuged at 1000×g for 10 min. Serums were separated from the blood sample and stored at - 20 ℃. The serum calcitonin gene-related peptide (CGRP) concentrations will be measured by adapting the enzyme-linked immunosorbent assay (ELISA) kit following manufacturer protocols.~Serum level CGRP before starting treatment and after three months of treatment~MRI T1, T2, and flair to exclude any secondary cause of headache.~Lacosamide: all patients received lacosamide 50 mg twice daily
We assessed serum CGRP concentrations in forty migraine patients according to the International Classification of Headache Disorders 3rd edition aged 10-55 years with migraines before and after receiving lacosamide 50 mg Bid for 3 months