This research study is a chemoprevention clinical trial, designed to test the safety and effectiveness of an investigational intervention to learn whether the intervention works in treating a specific disease. Investigational means that the drug is being studied. The investigators plan to recruit 80 participants.~Coffee is a complex mixture of hundreds of bioactive compounds, including caffeine, chlorogenic acids, and other polyphenols. Increasing data suggest the anti-cancer benefit of coffee. Observational data have linked coffee drinking to better survival among patients with colorectal cancer. However, there remains uncertainty surrounding the mode of action.~The U.S. Food and Drug Administration (FDA) has not approved coffee as a treatment for any disease.~The research study procedures include:~screening for eligibility.~Two study visits~Proton magnetic resonance spectroscopy.~Ultrasound elastography.~Urine, blood, and stool samples collected.~Diet and lifestyle questionnaires~Collection of archival tumor biopsy tissue.~Treatment: Coffee or placebo administered daily, orally for 8-12 weeks.
This is research study is assessing the effects of 6-g daily use of freeze-dried instant coffee on liver fat and fibrosis and the gut microbiome and metabolome in patients who have undergone surgery for stage I or II colon cancer or undergone surgery and completed chemotherapy for stage III colon cancer.