Ethical committee approval has been obtained from Ethics committee of Faculty of Medicine, Alexandria University.~All participants should agree to take part in this clinical study and will provide informed consent.~Eighty chronic kidney disease patients,will be recruited from the Kidney and Urology Center (KUC) and Alexandria main university hospital (AMUH).~The 80 participants will be randomly assigned into 2 arms.~Control arm (n=40): will be treated with standard treatment without any herbal intervention.~Intervention arm (n=40): will be treated with standard treatment in addition to gum acacia sachets. Each sachet contains 25 g of gum acacia powder to be taken on daily-basis for 3 months.~All patients will be submitted to :~Full patient history and clinical examination.~Blood withdrawal in order to conduct lab work.~Patients demographic data will be recorded with respect to age, weight and other co-morbidities.~Statistical tests appropriate to the study design will be conducted to evaluate the significance of the results.~Results, conclusion, discussion and recommendations will be given.
The aim of the study is to evaluate the impact of gum acacia on serum levels of protein-bound uremic toxins (indoxyl sulfate and p-cresyl sulfate).In addition to the evaluation of its effect on metabolic profile and disease progression in chronic kidney disease patients.