Primary outcome Postoperative pain measured using numerical rating scale (NRS)~After placement of intracanal medicament at 6, 12, 24 and 48 hours.~After root canal obturation at 6, 12, 24 and 48 hours.~Secondary outcomes Bacterial load reduction determined by bacterial counting using agar culture technique after root canal preparation (CFU/ml) .~Sample 1 (S1): after access preparation and pre-instrumentation.~Sample 2 (S2): post-instrumentation.~Sample 3 (S3): post-intracanal medicament removal at 3 or 7 days according to the group.
This research will study the effect of Boswellia Sacra versus calcium hydroxide as an intracanal medicament on postoperative pain intensity measured using numerical rating scale (NRS) and bacterial load reduction reduction determined by bacterial counting using agar culture technique after root canal preparation (CFU/ml) in mandibular premolars with necrotic pulp.