STUDY DESIGN:~This protocol is a single-center, single-cohort, bioresearch study enrolling up to 8 participants. The cohort is as follows:~Cohort 1: Colorectal Cancer: (n=8)~The study will enroll participants per the eligibility criteria.~Participants will have 2 scheduled at-home stool self-collections at the time points specified in section 4.0 and complete a questionnaire by telephone contact (see section 11.0 for details). The biospecimens collected from participants on this study are stool samples.~Confirmation of eligibility and medical record review by a member of the study staff will be completed for participants of the disease cohort before they are considered fully enrolled.
The primary objective of the study is to determine whether there is a correlation between the intestinal side effects of chemotherapy treatment and the expression/activity profiles of glucuronidase enzymes in the stool microbiome of the target patient population.