Assignment: All study subjects will undergo the same interventions.~Delivery of Interventions:~The subject will undergo a review of their medical history, physical exam, and screening laboratories.~A pelvic ultrasound will be performed to assess baseline follicular size.~A pump will be placed to administer pulsatile SC kisspeptin for two weeks.~During the course of kisspeptin administration, subjects will 1)Undergo q10 min blood sampling (approximately 4 sessions, 2 hours each) 2) Undergo pelvic ultrasounds (approximately 4 sessions)~Optional q10 min sampling up to 10 hours may take place before and after the course of kisspeptin
The investigators are recruiting women with hypothalamic amenorrhea or Idiopathic Hypogonadotropic Hypogonadism. Kisspeptin will be administered subcutaneously (SC) for 2-weeks in a pulsatile fashion. Ultrasound monitoring of ovarian follicular growth and frequent blood sampling (q10 min for up to 2hr) will be performed to assess the physiologic response to kisspeptin over time.