Treatment given to patients whose disease has not responded to (refractory) or returned (relapsed) after previous treatment is known as salvage treatment.~The standard of care for patients who are not in a study is salvage treatment with gemcitabine, dexamethasone and cisplatin (GDP). This treatment can reduce symptoms and may stop the lymphoma from growing for a few months or longer. This standard treatment is approved by Health Canada~We are doing this study because we want to find out if treatment with Pembrolizumab and Brentuximab vedotin is better or worse than the standard of care for this type of cancer, classical Hodgkin lymphoma. The standard of care is defined as care most people get for your cancer.
This study is being done to determine if two new drugs can shrink or eliminate classical Hodgkins lymphoma.