Population: 118 patients and 118 control subjects Act of research: blood test~Objectifs :~Comparison of glucocerebrosidase activity between patients and controls~Search for variants or mutations of the GBA gene and correlation with glucocerebrosidase activity~Correlation between clinical characteristics (UPDRS motor scale, MMSE cognitive scale) and GCase activity in patients
This research focuses on the activity of an enzymatic protein: glucocerebrosidase, in dementia with lewy bodies (DLB). Indeed, the mutation of the GBA gene responsible for a decrease in the activity of glucocerebrosidase is the most frequent known genetic risk factor in DLB. However, mutations of the GBA gene are known in another pathology, Gaucher disease, in which treatments have been developed.~The objective of this research is to determine if glucocerebrosidase activity is decreased in DLB. This hypothesis could open up a therapeutic perspective, with treatments already used in Gaucher disease.