This study is retrospective/prospective clinical observational study.~Primary Objective, Study Phase A (hospitalization, retrospective data collection):~To describe the development and characteristics of Covid-19 pneumonia, clinically and using radiological methods (i.e. CT-thorax)~To describe disease severity of Covid-19 disease, including treatment in Intensive Care Unit (ICU) and ventilation support measures~To describe different types of organ failures apart from respiratory failure (e.g. kidney, liver, heart)~To describe treatment outcomes at discharge, including cause of death~To assess the significance of additional risk factors such as HIV infection, smoking, malnutrition, etc., for the clinical course and characteristics of a Covid-19 disease Primary Objective, Study Phase B (after end of hospitalization, prospective data collection): The primary objective of the study phase B (after end of hospitalization) is the description of Covid-19 sequelae (focus on cardio-pulmonary morbidity) in patients with and without previous TB disease during a six month follow up period after discharge from hospital, including:~the description (characteristics and severity) of abnormal function tests and clinical examination results (e.g. in lung function measurement, cardiac tests and ECG, kidney function, neurological & mental tests)~the definition of time to healing (ad integrum) after a Covid-19 infection~the studying of chronic restrictions of the long-term quality of life at 12 months after discharge from hospital that are based on chronic organ failures and mental disorders~the assessment of exacerbations of chronic organ failures, hospitalizations and deaths in 12 months phase after discharge from hospital~Secondary Objective(s):~To collect longitudinal data that could allow for further insights on whether previous Covid-19 disease results in an increased risk for re-activation of~/infection with M. tuberculosis~To perform longitudinal immunological investigations in a sub-set of patients to study Covid-19- immune-activation, depending on M.tb and/or HIVcoinfection status
This study has two main objectives. First, the clinical characteristics and outcomes of hospitalized patients with symptomatic Covid-19 disease will be compared between persons with a history of past or current TB infection or disease and those, who have had no TB history. The possible impact of an HIV-coinfection will be also addressed in the planned investigations and analysis. Second, the long-term consequences and clinical outcomes of Covid-19 up to 12 months post-infection will be analysed in both groups (with and without TB history) with the main focus on cardio-pulmonary outcomes.