This study will be carried out in 2 emergency departments (at the exit of the emergency room, patients included in the GR2 study) and 2 external consultations (endocrinology of the CHU FB Monastir and diabetology consultation, Jemmal hospital).~All the population will benifit of a biological assessment which include:~Complete lipid profile, blood sugar, creatinine~HbA1c (if the patient is diabetic).~Inflammatory assessment: reactive protein C~Three populations will be randomized:~The population of patients with hypertension.~The population with diabetes.~The population of patients with other risk factors with a Framingham> 20% In each study population, the patient will be assigned to one of two treatments (atherolive or placebo). The study drug (atherol) will be prescribed at a dose of 400 mg, once a day for 3 months. The placebo will be prescribed identically.~For patients in the hypertension group:~A blood pressure or glycemic holter will be carried out for 24 hours respectively and diabetics.~The raw data (hourly averages) are stored on a computer .~For diabetic patients:~Continuous blood glucose monitoring to measure indices of glycemic variability is performed at baseline. These patients will be equipped with an iPro continuous glycemic monitoring~For other patients (Framingham> 20%) For this group, the initial assessment will also include a specific assessment. Assessment of endothelial function by the digital plethysmography method to measure flow-mediated dilation (FMD or flow-mediated dilation expressed by the RHI) and specific biological assesement ( Willebrand factor, Homocystein )
This study will be carried out in 2 emergency departments (at the exit of the emergency room) and 2 external consultations (endocrinology of the CHU FB Monastir and diabetology consultation, Jemmal hospital).~Patients over 18 years of age with:~Arterial hypertension (hypertension).~Or diabetes.~Or one or more other cardiovascular risk factors (AHA, ESC) or risk of cardiovascular disease> 20% according to the Framingham scale (apart from hypertension and diabetes were included.