PRIMARY OBJECTIVE:~I. To determine the effect of fisetin on physical function, as assessed using the 6-minute walk distance (6MWD), in postmenopausal breast cancer survivors.~SECONDARY OBJECTIVES:~I. To determine the effect of fisetin on other measures of physical function (grip strength, short physical performance battery [SPPB].
This phase II trial tests whether fisetin works to improve physical function in older women who have received chemotherapy for stage I-III breast cancer treatment. Fisetin is a naturally occurring substance that is found in strawberries and other foods. Fisetin eliminates cells that have undergone a process called senescence. Senescence is when a cell ages and permanently stops dividing but does not die. Over time, large numbers of these cells build up in tissues throughout the body and can release harmful substances that causes inflammation and damages nearby healthy cells. Studies have shown that chemotherapy causes a build-up of these senescent cells. Giving fisetin may eliminate senescent cells and improve physical function in postmenopausal women who have received chemotherapy for breast cancer.