study will include up to 45 (up to 30 patients per site), ages of 21 -75 of obese patients (BMI 30-40 kg/m²) who failed to reduce weight with non-surgical weight-loss methods.~At least 50% of the population included in the study diagnosed with Type 2 diabetes (T2D), and with HbA1c < 9 at least 6 months prior to study enrollment, excluding Insulin-dependent and / or At least 50% of the population included in the study diagnosed with hypertension, treating with 2 or more antihypertensive medications and are well control at least 6 months prior to study enrollment.~The duration for each participant will be 12 months and will include the following follow up visits and procedures:~Office visits: screening, procedure day, 1 week, and 1, 2, 4, 6, 8, 10, and 12 month(s)~Remote follow up (by Phone): 3, 5, 7, 9, and 11 month(s)~Endoscopy: procedure day and 2 months~Electrocardiogram (ECG) test: Screening and procedure day~FibroScan test: Screening, 6 and 12 months~24- hours Home Ambulatory Blood Pressure Monitor (ABPM), only for patients diagnosed with hypertension: Screening, 6 and 12 months~Laboratory tests including: (1) Hematology blood tests, (2) Biochemistry blood tests for: sugar Metabolism, liver, proteins, and lipid (3) Urinalysis (Dipstick) tests: Screening, 6 and 12 months.~Physical examination (include at minimum examination of: GI, Cardiopulmonary, Hepatobiliary and extremities systems) - Screening and procedure day.~Vital signs (blood pressure and heart rate - supine, pulse, body temperature, respiratory rate (RR) and SpO2): Screening, procedure day, 1 week, 1, 2, 4, 6, 8, 10 and 12 months~BMI and Waist circumference: Screening, procedure day, 1 week, 1, 2, 4, 6, 8, 10 and 12 months~Meeting with dietitians / lifestyle modifications counseling: at all follow up office and remote visits:~Office visit: Screening, procedure day, 1 week, 1, 2, 4, 6, 8, 10 and 12 months~Remote follows up (phone calls) at months 3,5,7,9, and 11.~IWQOL-Lite: Screening, 2, 6 and 12 months~PHQ-9: Screening~Pregnancy test (only for the relevant population): Procedure day~The patient will required to follow a specific diet and to have a physical activity during the study period ( 12 month).
multicenter, prospective, single arm study will include up to 45 patients, (up to 30 patients per site), aimed at evaluating the performance of the EndoZip System in obese patients with type 2 diabetes and / or hypertension who failed to reduce weight with non-surgical weight-loss methods.~Patients will be enrolled in 2 clinical sites in Europe. Patients who meet the eligibility criteria is expected to come the clinic for at least 10 visits.