Clomiphene, PTX and ALA each used in treatment of pco but they do so by different mechanisms.~Clomifene is in the selective estrogen receptor modulator (SERM) family of medication. It works by causing the release of gonadotropin-releasing hormone by the hypothalamus, and subsequently gonadotropin from the anterior pituitary.~PTX and ALA are used in treatment of pco due its anti-oxidant effect.
This study evaluate the addition of PTX and ALA to clomiphene citrate in the treatment of polycystic ovary.