Table 1. SOFA standardized protocol~Respiratory Protective mechanical ventilation; mechanical power < 16, NIV Prevention of PSILI: ROX and HACOR index~Hemodynamic SOSD protocol; Pressoric target; Lactate clearance~Neurologic Image; EEG; Sedation goals~Hematologic Basic disease approach; drugs; DDAVP use~Renal Avoid nephrotoxicity; Avoide hypotension~Hepatic Avoid hepatotoxic drugs; basic disease approach.
Introduction: The SOFA score (Sequential Organ Function Assessment) and its derived measures, such as the Delta SOFA, are used worldwide to determine the severity and prognosis of critically ill patients.~Objectives: The primary objective of this study was to assess the impact of standardized interventions on the six organ dysfunctions of SOFA score on outcomes of critically ill patients through the 48-hour delta SOFA score and 28 days mortality. The secondary outcome measures comprised the evaluation of standardized interventions on ICU and hospital length of stay ; duration of mechanical ventilation and time using vasoactive drugs. Uni and multivariate statistical analysis will be used to determine organ failures associated to outcome.~Methods: Interventional prospective cohort study involving patients admitted to three ICUs of a tertiary hospital from April 01, 2023 to March 31, 2024. Whenever an admission SOFA score ≥ 2 is identified a standardized protocol of interventions is implemented in the therapeutic plan of the patient (Table 1). A new SOFA score after 48 hours will determine the tendency of the SOFA Score (Delta SOFA) and the result will be correlated with the 28-day mortality