The primary objective of WAVE is to test the hypothesis that RFA is non-inferior to surgery in the biochemical (and if so, in the clinical) cure of unilateral PA, according to the international consensus PASO criteria.~Secondary objectives are to determine whether either intervention is superior to the other in relation to the following outcomes. Where no superiority of either intervention is established, non-inferiority of RFA against LA will be sought.~Frequency and severity of adverse events~Length of inpatient stay~Patient satisfaction~Quality of life~Return to work~An additional secondary objective in the RFA group alone will be anatomical efficacy of ablation.
A prospective randomised trial comparing radiofrequency ablation With laparoscopic Adrenalectomy as an alternatiVE treatment for unilateral asymmetric primary aldosteronism