Background:~Little evidence has been published demonstrating the advantages of IA versus EA.~Recent publications show the superiority of IA in terms of early functional digestive recovery, a shorter surgical incision, a lower need for analgesia, lower blood loss, and lower postoperative Clavien-Dindo grade. These results are similar to other further published studies, including multicenter randomized clinical trials and meta-analyses.~Methods:~This is a a long-term clinical follow-up study of 140 patients included preaviously in the single-blind single-center randomized prospective clinical trial conducted at the Hospital de la Santa Creu i Sant Pau (HSCSP) between 2015-2018; in which 30-day clinical outcomes after laparoscopic right colectomy for colon cancer with IA vs EA anastomosis were compared.~In this new trial, prospective clinical follow-up of the included 140 patients, randomized in two groups IA and EA, will be carried out, with a minimum time of 3 years.~The main objective of the study will be:~-Comparing long-term oncological outcomes of IA vs. EA anastomosis in laparoscopic right colectomy for malignant neoplasm.~The secondary objectives will be:~Analyzing the appearance of abdominal wall hernias and episodes of occlusion.~Describing the direct costs of both techniques retrospectively, through the financial records of the HSCSP institution.~The main hypothesis will be:~-IA is not inferior compared to EA in terms of oncological and clinical results, with a lower rate of abdominal postoperative hernias and occlusive/subocclusive episodes.~A regular prospective clinical follow-up through periodic medical visits and complementary tests established by the criteria of the Colorectal Cancer management protocol (document agreed by the HSCSP Colorectal Tumors Committee) will be conducted.~For the economic evaluation, all direct in-hospital costs that were registered by the HSCSP management will be analysed.~Extensive written information and an informed consent about the study will be provided to the patient.~The study does not entail any risk for the patient as it does not interfere with the usual follow-up or require extraordinary complementary studies.
Advantages of laparoscopic right colectomy with intracorporeal anastomosis (IA) compared to extracorporeal anastomosis (EA) are widely studied. Nowadays we can conclude, with a high level of scientific evidence, that there are a number of short-term clinical advantages of laparoscopic right colectomy with intracorporeal anastomosis (IA).~However, there is currently no randomized studies describing long-term clinical and oncological outcomes.