Part 1: The estimated time from screening until the follow-up phone call is approximately 6 weeks per subject.~Part 2: The estimated time from screening until the follow-up phone call is approximately 7 weeks per subject.~Part 3: The estimated time from screening until the follow-up phone call is approximately 7 weeks per subjects.
The purpose of this study is to evaluate safety and pharmacokinetics (PK) effect of belumosudil on the uridine diphosphate glucuronosyltransferase (UGT)1A1 (Part 1), P glycoprotein (P-gp) (Part 2) and breast cancer resistance protein (BCRP)/organic anion transporting polypeptide (OATP)1B1 (Part 3) inhibition in the fed state in healthy male subjects.