The subjects will be recruited during a medical visit in the Departments of Pneumology and Occupational and Environmental Pathologies.~After information and inclusion of the subject in the study, a collection of clinical data, the state of health and the smoking status of the subject will be carried out by the clinical study technician.~A collection of the exhalation will also be carried out by the clinical study technician.~Several groups of subjects will be formed according to pathologies (COPD versus non-COPD), age and smoking status
COPD and non-COPD patients will be included in the study after collection of their non-objection. The exhalation will be collected to study the microbiological diversity of human exhalations.~a second collection for the year +1 will be made, at the same time (between October and March).