200 adult subjects suffering from significant hand joint discomfort will be randomized per site in 2 parallel groups (100 subjects per group).~Each patient will be enrolled in the study for 3 months including 3 visits: Inclusion/Baseline visit (V0), follow-up visits after 1 month (V1) and 3 months (V2).~A-PRIMARY OBJECTIVE Evaluate the effect of the association of bioactive extracts of Curcuma longa CURTIL03 and Boswellia serrata BOSTIL01 versus placebo on the fingers pain after 3 months supplementation.~B-SECONDARY OBJECTIVES~Evaluate:~finger pain on both hands at 1 month (mean and AUC) and 3 months (AUC)~Functional disability at any timepoint (self-administrate questionnaire)~Participant Global Assessment (PGA) at any timepoint~To evaluate Minimum Clinically Important Improvement (MCII)~To calculate Participant Acceptable important Symptom State (PASS)~Consumption of rescue treatment (Paracetamol and oral NSAIDS) for hand pain at any timepoint~Tender and swollen joints at any timepoint~Grip strength at any timepoint~Quality of life (e.g. including mood, sleep, disability) at any timepoint~Tolerance to the product at 1 and 3 months~Compliance to the product at 1 and 3 months~Responder to supplementation at 1 and 3 months~EXPLORATIVE OBJECTIVES~• Evaluate the blood level of cartilage catabolism and inflammatory biomarkers before and after 3 months of supplementation.
The objective of the study is to evaluate the effect and tolerance of a correctly assimilable bioactive extract of Curcuma longa (CURTIL03) and of Boswellia serrata (BOSTIL01) among people with hand joint discomfort and dysfunction.~The study is prospective, randomized, double-blinded, placebo-controlled with 2 parallel-groups in 200 participants. The study is multicentric and will be done by 10 investigators located in Belgium including rheumatologists, sports and rehabilitation physicians, physical therapists, or any hand articular disease specialists.