Non-inferiority, prospective, multi-center, post-market, randomized 1:1 study. 90 patients with uncontrolled hypertension treated with 2 to 5 anti-hypertensive drugs including one Angiotensin Receptor Blocker (ARB) associated to one diuretic or Calcium Channel blocker.~12 sites will be selected in 3 countries (France, Germany and Monaco) to enroll 90 patients.~A parallel registry on radial approach only (patients who cannot be treated by femoral ) will have the same follow up.~Each patients will have two follow-ups:~at 3 months (90+14)~at 6 months (180+30)~The expected duration of the inclusion is 15 months. The estimated duration of the Study is 26 months.
Non-inferiority, prospective, multi-center, post-market, randomized 1:1 study in patients with uncontrolled hypertension to compare the safety and efficacy of radio frequency renal denervation using Iberis Renal Denervation System via radial access compared with femoral access.