This study aims to identify predictors of migraine onset in adolescent girls as well as to determine hormonal, psychophysical, and neural changes associated with migraine onset. The study procedures involve an MRI scan, sensory testing, blood draw, meeting with a specialist to determine migraine diagnosis, and completing surveys~After signing the informed consent/assent form, participant and the parents or legal gradian will participate in a study visit that will last approximately 3.5 hours. During the study visit participants will undergo psychophysical assessments, MRI scan, complete surveys, have a blood draw and meet (in person or via electronic communication) with a specialist or a trained study staff member to determine migraine status.~After completing the baseline study visit participants will participate in a 2-year follow-up. Participants will complete monthly surveys (via email/phone call/phone text/phone application). Participants will return for follow-up study visits after 1 and 2 years, which will include the same procedures as at baseline (MRI session, psychophysical session, completing surveys and a blood draw, and meeting with a pediatric headache/ pain specialist/trained study staff).
This study aims to identify predictors of migraine onset in adolescent girls using MRI, sensory testing, hormone blood analysis, and surveys.~Aim 1. To identify psychophysical and neural factors predicting migraine onset in adolescent girls~Aim 2. To determine hormonal, psychophysical, and neural changes associated with migraine onset.