PRIMARY OBJECTIVE:~I. To identify how diet, specifically fiber supplementation, alters the microbiome of the colonic mucosa.~OUTLINE:~Patients receive dietary fiber orally (PO) on study. Patients undergo proctoscopy or anoscopy with biopsy on study and during follow-up.
This clinical trial tests whether daily fiber supplementation will change the mucosal microbiome of the colon. The microbiome are microorganisms that live in the human gut. They serve a vital role in maintaining health. Certain microbial strains are associated with the growth of colon polyps, which eventually could go on to form colon cancer. Giving dietary fiber supplements may help prevent precancerous polyps from ever developing.