Sepsis patients admitted in the Department of Critical Care Medicine, Zhongnan Hospital will be included.~There are three groups of patients in this study: control group, sepsis group and septic shock group.~The interleukin-37 (IL-37) concentration in urine was analyzed in the day 1, 2, 4, 6.~Additionally, IL-37 concentration between blood stream infection groups and non-infection groups were analyzed. IL-37 concentration between survivors and non-survivors were also compared. IL-37 concentration were followed from day 1, 2, 4, 6.The correlation between the concentration of IL-37, IL-1β, IL-6、IL-10 and TNF-α were analyzed. Furthermore, the investigators will determine the correlation between the concentration of IL-37, sepsis associated organ dysfunction, 28-day mortality. Lastly, the predictive value of IL-37 to sepsis associated organ dysfunction and prognosis were explored.
This study aims to evaluate the efficacy of IL-37 as a biomarker to predict mortality risk in adults with sepsis.