The aim of this study is to determine the formation and progression of retinal changes caused by pentosan polysulfate sodium toxicity. To do this, we will measure how single cone photoreceptors respond to light in regions of the retina that are affected by pentosan polysulfate sodium toxicity. We will also measure how the retinal pigment epithelium, a layer of cells vital to photoreceptor health, change in shape and size over time.
Our goal is to determine the cellular scale changes that occur in subjects who have disease progression due to pentosan polysulfate sodium toxicity