Type of the study: observtional Study (clinical trial)~Intervention Model Description:~Patients will be two groups according to the surgical procedure performed as follows:~Group A: masseteric nerve to central branch facial nerve. (Early fibrillation on EMG)~Group B: Masseteric nerve to free functioning muscle transfer. (Late no fibrillation on EMG)~Allocation and Randomization:~Twenty-four patients will be assigned to Group A early or Group B late (2 groups). group A will be for early and be will be for late cases~Study Setting: Plastic and Reconstructive Surgery Department, Assuit University Hospital and San Paolo university hospital of Milano university.~Study subjects:~Inclusion criteria:~1.Facial nerve affection 2.Patients are generally fit with no other disease interfere with microsurgery. 3.Electromyography showing fibrillations for group A and no fibrillation for group B.~b. Exclusion criteria:~1.Patient with other medical or mental disease-causing generalized paralysis. 2.Syndromic cases. 3.Patients are generally unfit or with any disease interfere with microsurgery.~c. Sample Size Calculation: 24 Sample size was calculated using G power program version 3.1.9.4 (6) in order to detect a significant difference in mean of EFACE score (one of main assessed outcomes in the study ) between two groups under the study , assumed effect size 0.6 based on clinical assumption ( novel study ), α error 0.3 , power 0.80, and allocation ratio 1: 1.~Twenty-two patient plus 10% for dropouts to make total twenty-four (12 patient for every group).~Study tools~All patients in this study are subjected to:~Pre-operative Assessment:~Patient history.~All patients will do preoperative clinical and neurophysiological assessments of mimetic muscle function and donor nerve status (the ipsilateral deep temporal nerve. The neurophysiological tests will include needle Electromyography (EMG) for recruitment of residual motor unit action potential to determine which procedure~The trigeminal motor component will be tested by palpating the temporalis muscle and masseteric muscle during chewing and via needle EMG to verify availability as a donor motor nerve.~Photographic documentation preoperative using standardized EFACE view.~Ophthalmological assessment of the affected eye for detection of redness, ulcer, etc.~Surgical procedure:~Group A the investigators will avoid the use of muscle relaxants to induce anaesthesia and employ an electro-stimulator to identify the masseteric nerve and the facial nerve branches supplying the affected side.~Exploration on the affected side a facelift-type incision will be performed, and an anterior subcutaneous flap is then will be lifted for several centimetres. In the inferior zygomatic region, the plane of elevation is deepened into the sub-SMAS plane and a composite flap elevated for several centimetres. Following elevation in this plane, the distal facial nerve branches will be identified. The distal portion of the zygomatic nerve is usually located midway between the oral commissure and the helical root. and was confirmed by nerve stimulator.~Then masseteric nerve identified in masseteric muscle and then end to end anastomosis with the central branch of facial nerve Then suction drain will be put and will be removed after 24 hours. Group B The same technique of face lift and harvest the free functioning muscle flap and micro anastomosis of the flap for the superficial temporal system or the facial artery system and the same technique for masseteric nerve identification and end to end anastomosis and to side for prepare cross nerve form the stage one Post-operative All patient will receive physiotherapy and post-operative follow up to detect any wound complication.~Evaluation (After 6 months from the operation)~Photo documentation for EFACE~Donor site morbidity.~Onset of first movement~Patient satisfaction~Complications:~General surgical complication.~General complication due to general anaesthesia.~Specific complication:~Delayed healing of nerve anastomosis.~Affection of mastication.~No postoperative improvement.~Research outcome measures:~a. Primary (main): Comparing the outcomes on EFACE score~Secondary (subsidiary):~Easy technique for rapid masseteric nerve identification.~Effect of addition of contracted growth factor around the anastomosis~Procedure-related morbidity and mortality.~Effect of selective neurectomy for overactive affected branches with the total reanimation~The experience of adding another neural impots with masseteric nerve~Operative time and hospital stay.
The return of eyelid function and facial expression in Patients with facial nerve affection is very important for quality of life. Eyelid dysfunction leads to drying and ulceration of cornea which may lead to permanent vision loss.~Facial paralysis is distinguished into two main groups according to the presence or absence of facial fibrillations at needle Electromyography. Recent paralysis, mainly lasting less than two years generally show these signs and are eligible for reactivation of facial nerve by anastomosing it to a donor one (early facial reanimation).~The masseteric nerve (motor branch of trigeminal nerve ) is a reliable donor nerve on early facial reanimation So on this study we examine the advantages and disadvantages of using masseteric nerve to develop a protocol for use of facial reanimation and restoration of function on facial paresis.