Design, synthesis and antitubercular activity of diarylmethylnaphthol derivatives.
Das SK, Panda G, Chaturvedi V, Manju YS, Gaikwad AK, Sinha S.
A new series of diarylmethylnapthyloxy ethylamines were synthesized by aminoalkylation of diarylmethylnaphthols which were obtained by Friedel-Crafts alkylation on 1- and 2-naphthols using diarylcarbinols as the alkylating agents. The title compounds were evaluated for antitubercular activity against Mycobacterium tuberculosis H(37)R(v) in vitro and showed MIC in the range of 3.12-25 microg/ml.