Data for DCP probe A-1596586
SGC Frankfurt
SGC Frankfurt donated chemical probe project: A-1596586 was donated by Abbvie. Website: https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/A-1596586. Control: A-1596584. References: 1. Wang, Xueqing, Bo Liu, Xenia Searle, Clinton Yeung, Andrew Bogdan, Stephen Greszler, Ashvani Singh, Yihong Fan, Andrew M Swensen, Timothy Vortherms, Corina Balut, Ying Jia, Kelly Desino, Wenqing Gao, Hong Yong, Chris Tse, and Philip Kym. 2018. ‘Discovery of 4-[(2R,4R)-4-({[1-(2,2-Difluoro-1,3-Benzodioxol-5-Yl)Cyclopropyl]Carbonyl}amino)-7-(Difluoromethoxy)-3,4-Dihydro-2H-Chromen-2-Yl]Benzoic Acid (ABBV/GLPG-2222), a Potent Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Corrector for the Treatment of Cystic Fibrosis’. Journal of Medicinal Chemistry 61(4):1436–49. PMID: 29251932 (Probe: Cmp.13, control: Cmp. 12).