Trigoxyphins H and I: two new daphnane diterpenoids from Trigonostemon xyphophylloides.
Yang B, Chen GY, Song XP, Yang LQ, Han CR, Wu XY, Li XM, Zou BY.
Two new daphnane diterpenoids (1 and 2), together with four known analogues (3-6) were isolated from Trigonostemon xyphophylloides. Their structures were elucidated by spectroscopic analysis. Compounds 1 and 2 were evaluated for in vitro cytotoxic activities against the SPCA-1 (human lung cancer) and BEL-7402 (human hepatocellular carcinoma) cancer cell lines. Trigoxyphin I (2) showed modest cytotoxicity against two tumor cell lines.