Synthesis of novel antiproliferative hybrid bis-(3-indolyl)methane phosphonate derivatives.
Maestro A, Martín-Encinas E, Alonso C, Martinez de Marigorta E, Rubiales G, Vicario J, Palacios F.
An efficient synthetic methodology for the preparation of phosphorus substituted bis-(3-indolyl)methane through a double nucleophilic addition of indole derivatives to an in situ generated α-iminophosphonate is reported. In addition, bis-(3-indolyl)methane substrates showed in vitro cytotoxicity, inhibiting the growth of carcinoma human tumor cell lines A549 (carcinomic human alveolar basal epithelial cell) and SKOV03 (human ovarian carcinoma).