Methionyl adenylate analogues as inhibitors of methionyl-tRNA synthetase.
Lee J, Kang SU, Kang MK, Chun MW, Jo YJ, Kwak JH, Kim S.
Four stable analogues of methionyl adenylate (3-6) were designed as inhibitors of methionyl-tRNA synthetase and synthesized from 2',3'-isopropylideneadenosine. They strongly inhibited aminoacylation activity of methionyl-tRNA synthetases isolated from Escherichia coli, Mycobacterium tuberculosis, Saccharomyces cerevisiae and human. Among the microorganisms tested, however, these chemicals showed the growth inhibition effect only on E. coli.