A synthetic 2,3-diarylindole induces cell death via apoptosis and autophagy in A549 lung cancer cells.
Rukkijakan T, Ngiwsara L, Lirdprapamongkol K, Svasti J, Phetrak N, Chuawong P.
A series of 2,3-diarylindoles were synthesized via the Larock heteroannulation, and evaluated for their anticancer activity against A549 lung cancer cells. The most potent compound, PCNT13 with IC50=5.17 μM, caused the induction of two modes of programmed cell death, apoptosis and autophagy.