Synthesis and antimycobacterial activity of novel 1,3-dimethylisocyanurate derivatives.
Shulaeva MM, Fattakhov SG, Saifina LF, Chestnova RV, Valijev RSh, Mingaleev DN, Voloshina AD, Reznik VS.
A series of novel 1,3-dimethylisocyanurates has been synthesized as potential inhibitors of β-ketoacyl synthase in mycobacteria. Most of the 25 compounds described and tested for their activity against M. tuberculosis have a bacteriostatic effect, comparable and even higher that of first-line antituberculosis drugs. These compounds are nontoxic, species-specific, exhibiting no activity against other bacterial species.