9-Deoxopodophyllotoxin derivatives as anti-cancer agents.
Subrahmanyam D, Renuka B, Kumar GS, Vandana V, Deevi DS.
Several 9-deoxo-9-substituted podophyllotoxin derivatives were synthesised starting from naturally occuring podophyllotoxin and their anti-cancer activity was evaluated against in vitro human cancer cell line assay. It was observed that these compounds do possess good anti-cancer activity particularly against ovarian, renal and lung cancer cell lines.