Novel inhibitors of procollagen C-proteinase. Part 2: glutamic acid hydroxamates.
Robinson LA, Wilson DM, Delaet NG, Bradley EK, Dankwardt SM, Campbell JA, Martin RL, Van Wart HE, Walker KA, Sullivan RW.
Glutamic acid derived hydroxamates were identified as potent and selective inhibitors of procollagen C-proteinase, an essential enzyme for the processing of procollagens to fibrillar collagens. Such compounds have potential therapeutic application in the treatment of fibrosis.