Click reaction synthesis of carbohydrate derivatives from ristocetin aglycon with antibacterial and antiviral activity.
Pintér G, Bereczki I, Batta G, Otvös R, Sztaricskai F, Roth E, Ostorházi E, Rozgonyi F, Naesens L, Szarvas M, Boda Z, Herczegh P.
New sugar derivatives of ristocetin were prepared by copper-catalyzed 1,3-dipolar cycloaddition reaction using azido-ristocetin aglycon and various propargyl glycosides. Some of them were found to be active against gram-positive bacteria and showed favorable antiviral activity against the H1N1 subtype of influenza A virus.