Synthesis and selective cytotoxic activity of novel hybrid chalcones against prostate cancer cells.
Nagaraju M, Gnana Deepthi E, Ashwini C, Vishnuvardhan MV, Lakshma Nayak V, Chandra R, Ramakrishna S, Gawali BB.
A new class of hybrid chalcones (17a-l &18a-l) was synthesized by Claisen-Schmidt condensation. All compounds were characterized by (1)H NMR, IR and mass spectral analysis and tested for their cytotoxic activity against PC-3 (prostate cancer), HT-29 (colon cancer), B-16 (mouse macrophages) and NCI-H460 (lung cancer) cell lines. Three compounds 18i, 18j and 18l (IC(50)=8.4, 7.9 & 5.9 μM) showed significant activity against PC-3 cell line.