Quinonoid and phenazine compounds: synthesis and evaluation against H37Rv, rifampicin and isoniazid-resistance strains of Mycobacterium tuberculosis.
Carneiro PF, Pinto Mdo C, Coelho TS, Cavalcanti BC, Pessoa C, de Simone CA, Nunes IK, de Oliveira NM, de Almeida RG, Pinto AV, de Moura KC, da Silva PA, da Silva Júnior EN.
Several quinonoid and phenazine compounds were synthesized in moderate to high yields and showed activity against H(37)Rv, rifampicin and isoniazid-resistance strains of Mycobacterium tuberculosis. The cytotoxity of the compounds were evaluated against human peripheral blood mononuclear cells (PBMC) and these substances emerge as promising antitubercular prototypes.