Hemisynthetic secofriedelane triterpenes with inhibitory activity against the growth of human tumor cell lines in vitro.
Moiteiro C, Manta C, Justino F, Tavares R, Curto MJ, Pedro M, Nascimento MS, Pinto M.
Seco acids 7 and 9 and hydroxylated analogues 5 and 6 derived from friedelane triterpenes were synthesized stereoselectively in high yields. Compounds 5-9 were evaluated for their ability to inhibit in vitro the growth of three human tumor cell lines, MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer), and SF-268 (CNS cancer). Only compounds 7 and 9 were found to possess significant growth inhibitory effects, exhibiting GI(50) values that range from 24.6 to 32.8 microM and 10.9 to 17.6 microM, respectively.