Semisynthesis of triptolide analogues: effect of γ-lactone and C-14 substituents on cytotoxic activities.
Aoyagi Y, Hitotsuyanagi Y, Hasuda T, Fukaya H, Takeya K, Aiyama R, Matsuzaki T, Hashimoto S.
Triptolide γ-lactone and C-14 analogues were prepared and evaluated cytotoxity against human lung adenocarcinoma epithelial A549 cells and human colon adenocarcinoma HT-29 cells. γ-Lactone substructure and C-14 substituents affected the biological activities significantly.