A concise diastereoselective approach to enantioenriched substituted piperidines and their in vitro cytotoxicity evaluation.
Kumaraswamy G, Kumar RS, Sampath B, Poornachandra Y, Ganesh Kumar C, Vemulapalli SP, Bharatam J.
A library of diversely stereo-oriented, highly substituted 2,6-cis piperidine derivatives were synthesized, and evaluated for their anticancer activity in cancer cells that included A549 (lung cancer, CCL-185), MCF7 (breast cancer (HTB-22), DU145 (prostate cancer (HTB-81), and HeLa (cervical cancer, CCL-2). One stereo-variant emerged as a promising candidate for further design based structure-activity studies.