8-Methoxyquinoline-5-carboxamides as PDE4 inhibitors: a potential treatment for asthma.
Buckley GM, Cooper N, Dyke HJ, Galleway FP, Gowers L, Haughan AF, Kendall HJ, Lowe C, Maxey R, Montana JG, Naylor R, Oxford J, Peake JC, Picken CL, Runcie KA, Sabin V, Sharpe A, Warneck JB.
A series of bicyclic heteroaryl ring systems was considered as a replacement for the 3-cyclopentyloxy-4-methoxyphenyl moiety in rolipram resulting in the discovery of 8-methoxyquinoline-5-carboxamides as potent inhibitors of phosphodiesterase type 4 (PDE4).