Phenylimidazole derivatives as new inhibitors of bacterial enoyl-ACP reductase FabK.
Kitagawa H, Ozawa T, Takahata S, Iida M.
Novel FabK inhibitors with antibacterial activity against Streptococcus pneumoniae were synthesized and evaluated. Through SAR studies of our initial hit compound 2-(1H-benz[d]imidazol-2-ylthio)-N-(6-methoxycarbonylbenzo[d]thiazol-2-yl)acetamide, a series of novel phenylimidazole derivatives were discovered as potent FabK inhibitors.