Peptidomimetic inhibitors of bacterial peptide deformylase.
East SP, Ayscough A, Toogood-Johnson I, Taylor S, Thomas W.
A series of N-formyl hydroxylamine peptide deformylase inhibitors containing a cyclic azaamino acid moiety between the P1' and P3' substituents are presented. Selected compounds display antibacterial activity against pathogens associated with respiratory tract infections with representative compounds showing excellent MICs against Haemophilus influenzae.