Synthesis of fluorescent ristocetin aglycon derivatives with remarkable antibacterial and antiviral activities.
Sipos A, Máté G, Rőth E, Borbás A, Batta G, Bereczki I, Kéki S, Jóna I, Ostorházi E, Rozgonyi F, Vanderlinden E, Naesens L, Herczegh P.
Isoindole and benzoisoindole derivatives of ristocetin aglycon have been prepared by reaction with o-phthalaldehyde or naphthalene-2,3-dialdehyde and various thiols. The new compounds exhibited potent antibacterial and anti-influenza virus activity. The cluster forming and fluorescent properties of the aglycon derivatives were also studied.