New rifabutin analogs: synthesis and biological activity against Mycobacterium tuberculosis.
Barluenga J, Aznar F, García AB, Cabal MP, Palacios JJ, Menéndez MA.
The synthesis, structure, and biological evaluation of a series of novel rifamycin derivatives, Rifastures (RFA) with potent anti-tuberculosis activity are presented. Some of these derivatives showed higher in vitro activity than rifabutin and rifampicin against not only Mycobacterium tuberculosis strains but also against MAC and Mycobacterium kansasii.