Indolequinone antitumor agents: relationship between quinone structure and rate of metabolism by recombinant human NQO1.
Beall HD, Hudnott AR, Winski S, Siegel D, Swann E, Ross D, Moody CJ.
A series of indolequinones bearing various functional groups has been synthesized, and the effects of substituents on the metabolism of the quinones by recombinant human NAD(P)H:quinone oxidoreductase (NQO1), and on the toxicity toward nonsmall cell lung cancer cells with either high NQO1 activity (H460) or with no detectable activity (H596) were studied.