Synthesis and pharmacological activities of 13-dehydro derivatives of primary prostaglandins.
Tanami T, Kameo K, Ono N, Nakagawa T, Annou S, Tsuboi M, Tani K, Okamoto S, Sato F.
13-Dehydro derivatives of prostaglandin E1, E2, E3, F1 alpha and F2 alpha were synthesized. Compared with natural prostaglandins, 13-dehydro analogues were found to exhibit more potent inhibitory activity against human platelet aggregation and relaxation of guinea-pig isolated trachea, while they showed less potent activity of contraction of guinea-pig isolated ileum.