Synthesis and in vitro anti Mycobacterium tuberculosis activity of a series of phthalimide derivatives.
Santos JL, Yamasaki PR, Chin CM, Takashi CH, Pavan FR, Leite CQ.
New phthalimide derivatives were easily prepared through condensation of phthalic anhydride and selected amines with variable yields (70-90%). All compounds (3a-l) were evaluated against Mycobacterium tuberculosis H(37)Rv using Alamar Blue susceptibility. The compounds 3c, 3i, and 3l have the minimum inhibitory concentrations (MICs) of 3.9, 7.8, and 5.0 microg/mL, respectively, and could be considered new lead compounds in the treatment of tuberculosis and multi-drug resistant tuberculosis.