Synthesis of penaresidin derivatives and its biological activity.
Ohshita K, Ishiyama H, Takahashi Y, Ito J, Mikami Y, Kobayashi J.
A series of stereoisomers for the azetidine ring of penaresidin B was synthesized and their cytotoxic and antimicrobial activities were evaluated. Among six synthetic isomers 1-6, isomers 4 and 5 showed relatively potent cytotoxic activity against A549 (lung) and HT29 (colon) tumor cells as well as antibacterial activity.