Benzimidazoles as new potent and selective DP antagonists for the treatment of allergic rhinitis.
Beaulieu C, Wang Z, Denis D, Greig G, Lamontagne S, O'Neill G, Slipetz D, Wang J.
A series of 2-substituted N-benzyl benzimidazole containing molecules has been synthesized and its structure-activity relationship for the human DP receptor has been evaluated. Selective DP antagonists with nanomolar potency for the DP receptor were identified in this novel series of benzimidazoles.