Antitumor agents, 116. Cytotoxic triterpenes from Maytenus diversifolia.
Nozaki H, Matsuura Y, Hirono S, Kasai R, Chang JJ, Lee KH.
The known triterpenes 3-oxofriedelan-29-oic acid [1], 3-oxofriedelan-28-oic acid [2], and 28,29-dihydroxyfriedelan-3-one [3] have been isolated from Maytenus diversifolia. Compounds 1-3 demonstrated cytotoxicity against the A-549 lung carcinoma cells with ED50 values of 0.21, 1.18, and 0.64 micrograms/ml, respectively.