A macrolactone from benzo[a]phenazine with potent activity against Mycobacterium tuberculosis.
Silva RS, Pinto Mdo C, Goulart MO, de Souza Filho JD, Neves I, Lourenço MC, Pinto AV.
We report here an alternative to the MCPBA or ozonolysis-based oxidation methods of quinoxaline-featuring compounds prepared from beta-lapachones. The use of peracetic acid allowed a simple preparation of the corresponding macrolactones by cleavage of the ring system. These lactones were evaluated for their antimycobacterial potential and compound 4 turned out to have an MIC of 0.62 microg per mL on Mycocabteriumtuberculosis H37Rv. These results justify further research into its value as a potential lead for an original treatment of tuberculosis.