Green synthesis and anti-infective activities of fluorinated pyrazoline derivatives.
Shelke SN, Mhaske GR, Bonifácio VD, Gawande MB.
A new series of fluorinated pyrazoles, 4a-e, were synthesized in good to excellent overall yields (65-82%) from the corresponding chalcones, 3a-e, by ultrasonic irradiation. The newly synthesized compounds were characterized and screened for their in vitro anti-bacterial, anti-fungal, and anti-tubercular activities against Mycobacterium tuberculosis H(37)Rv.