Isosteric ribavirin analogues: Synthesis and antiviral activities.
Zhurilo NI, Chudinov MV, Matveev AV, Smirnova OS, Konstantinova ID, Miroshnikov AI, Prutkov AN, Grebenkina LE, Pulkova NV, Shvets VI.
The novel isosteric ribavirin analogues were synthesized by two different ways. Some of them showed significant antiviral action against hepatitis C virus (HCV), herpes simplex (HCV-1) and influenza A virus comparable to that of ribavirin itself. The data obtained confirm the proposed theory of the ribavirin possible antiviral activity mechanism related with bioisosterism.