Synthesis and biological evaluation of novel bisheterocycle-containing compounds as potential anti-influenza virus agents.
Wang WL, Yao DY, Gu M, Fan MZ, Li JY, Xing YC, Nan FJ.
A series of novel 4,2-bisheterocycle tandem derivatives consisting of a methyloxazole and thiazole subunit were synthesized. Many compounds were found to inhibit human influenza A virus. Several analogues exhibited moderate biological activity and could serve as leads for further optimizations for antivirus research.