One-pot synthesis of polyunsaturated fatty acid amides with anti-proliferative properties.
Tremblay H, St-Georges C, Legault MA, Morin C, Fortin S, Marsault E.
A one-pot environmentally friendly transamidation of ω-3 fatty acid ethyl esters to amides and mono- or diacylglycerols was investigated via the use of a polymer-supported lipase. The method was used to synthesize a library of fatty acid monoglyceryl esters and amides. These new derivatives were found to have potent growth inhibition effects against A549 lung cancer cells.