Synthesis and evaluation of antitubercular activity of glycosyl thio- and sulfonyl acetamide derivatives.
Ghosh S, Tiwari P, Pandey S, Misra AK, Chaturvedi V, Gaikwad A, Bhatnagar S, Sinha S.
A series of glycosyl thioacetamide and glycosyl sulfonyl acetamide derivatives have been prepared following a convenient reaction protocol and evaluated for their antitubercular activity against Mycobacterium tuberculosis H(37)Rv. Amongst 32 compounds evaluated 3 compounds were effective in inhibiting mycobacterial growth at MIC of 6.25 microg/mL, 6 compounds at MIC of 3.125 microg/mL and 1 compound at MIC of 1.56 microg/mL. All active compounds were found nontoxic in Vero cell lines and mice bone marrow macrophages.