Synthesis, antimycobacterial evaluation and pharmacophore modeling of analogues of the natural product formononetin.
Mutai P, Pavadai E, Wiid I, Ngwane A, Baker B, Chibale K.
The synthesis and antimycobacterial activity of formononetin analogues is hereby reported. Formononetin and its analogue 11E showed 88% and 95% growth inhibition, respectively, against the H37Rv strain of Mycobacterium tuberculosis. Pharmacophore modeling studies indicated that the presence of a hydroxyl group in formononetin and its analogues, is crucial for maintaining activity.