Analysis of β-amino alcohols as inhibitors of the potential anti-tubercular target N-acetyltransferase.
Fullam E, Abuhammad A, Wilson DL, Anderton MC, Davies SG, Russell AJ, Sim E.
The synthesis and inhibitory potencies of a novel series of β-amino alcohols, based on the hit-compound 3-[3'-(4''-cyclopent-2'''-en-1'''-ylphenoxy)-2'-hydroxypropyl]-5,5 dimethylimidazolidine-2,4-dione as specific inhibitors of mycobacterial N-acetyltransferase (NAT) enzymes are reported. Effects of synthesised compounds on growth of Mycobacterium tuberculosis have been determined.