Effect of substituents on diarylmethanes for antitubercular activity.
Panda G, Parai MK, Das SK, Shagufta, Sinha M, Chaturvedi V, Srivastava AK, Manju YS, Gaikwad AN, Sinha S.
Aminoalkyl derivatives of diarylmethanes were prepared using Grignard, Friedel-Crafts arylation and aminohydrochloride chain formation reactions. These series of compounds were evaluated against Mycobacterium tuberculosis H(37)R(v) and showed the activity in the range of 6.25-25 microg/mL. Effect of heteroaryl, anthracenyl and phenanthrene groups on diarylmethane pharmacophores for antitubercular activity is described.