Synthesis and antimycobacterial activity of 5-formylaminopyrimidines; analogs of antibacterial purines.
Braendvang M, Charnock C, Gundersen LL.
Pyrimidine analogs of antimycobacterial purines have been synthesized and their biological activities evaluated. Several 5-formamidopyrimidines exhibited profound activity against Mycobacterium tuberculosis in vitro (IC(90)< or =1.5 microg/mL), and they were essentially inactive against other bacteria.