A novel indigoid anti-tuberculosis agent.
Klein LL, Petukhova V, Wan B, Wang Y, Santasiero BD, Lankin DC, Pauli GF, Franzblau SG.
The structure of a novel indigoid component was characterized by X-ray crystallography. This compound exhibited excellent anti-tuberculosis activity against Mycobacterium tuberculosis H37Rv in whole cell culture showing a submicromolar minimum inhibitory concentration (MIC). A synthesis of this molecule was designed and carried out to produce sufficient material for further testing. The in vitro profile, structure, and first synthesis of this indigoid component is reported.