Pulmonary versus systemic delivery of antibiotics: comparison of vancomycin dispositions in the isolated rat lung.
de Jesús Valle MJ, López FG, Hurlé AD, Navarro AS.
Vancomycin dispositions in the respiratory system were compared after systemic and inhalatory administration under two respiratory conditions using the isolated-lung model. Inhalatory delivery led to much higher drug levels in pulmonary tissue and fluids. The respiratory pattern affects vancomycin disposition in the pulmonary system regardless of the administration route.