Potential organ- or tumor-imaging agents. 18. Radioiodinated diamines and bisquaternaries.
Huang CC, Korn N, Counsell RE.
The purpose of this research was to employ diamines and their quaternary derivatives as carrier molecules for gamma-emitting radiation. The diamine putrescine is widespread in nature and has been reported to selectively concentrate in the rat ventral prostate and pancreas. This study confirms the selective uptake of radioactivity in the rat ventral prostate, but not in the pancreas, following administration of [14C]putrescine. The radioiodinated analogues of putrescine showed no predilection for either of these organs. On the other hand, radioactivity associated with a radioidinated quaternary derivative (3) was found to accumulate incartilaginous tissues such as trachea, intervertebral disks, and chondrosarcoma tumor in a manner simular to hexamethonium.